Roles > protein kinase A agonist
Page last updated: 2024-08-05 15:35:51

protein kinase A agonist

A protein kinase agonist that selectively binds to and activates a protein kinase A receptor

ChEBI ID: 78547

Members (1)

MemberDefinitionClass
colforsinA labdane diterpenoid isolated from the Indian Coleus plant.forskolin

Research

Studies (13,180)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19902,380 (18.06)18.7374
1990's5,894 (44.72)18.2507
2000's3,398 (25.78)29.6817
2010's1,292 (9.80)24.3611
2020's216 (1.64)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials46 (0.34%)5.53%
Reviews101 (0.75%)6.00%
Case Studies17 (0.13%)4.05%
Observational1 (0.01%)0.25%
Other13,295 (98.77%)84.16%

Protein Targets (54)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
AR proteinHomo sapiens (human)Potency13.1333611
aryl hydrocarbon receptorHomo sapiens (human)Potency19.736422
Ataxin-2Homo sapiens (human)Potency0.194012
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency0.230124
Cellular tumor antigen p53Homo sapiens (human)Potency0.485611
chromobox protein homolog 1Homo sapiens (human)Potency89.125111
cytochrome P450 2C9, partialHomo sapiens (human)Potency32.483012
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency12.117123
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency1.078612
estrogen nuclear receptor alphaHomo sapiens (human)Potency6.97621015
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency42.166022
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency2.851969
farnesoid X nuclear receptorHomo sapiens (human)Potency34.230022
GVesicular stomatitis virusPotency32.483012
gemininHomo sapiens (human)Potency23.109311
GLI family zinc finger 3Homo sapiens (human)Potency0.065924
glp-1 receptor, partialHomo sapiens (human)Potency1.696623
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency0.546812
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency11.426512
histone-lysine N-methyltransferase 2A isoform 2 precursorHomo sapiens (human)Potency10.000011
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency32.483012
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency32.483014
Interferon betaHomo sapiens (human)Potency32.483012
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency30.642122
nuclear receptor subfamily 1, group I, member 2Rattus norvegicus (Norway rat)Potency5.011911
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency25.665323
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency0.534422
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency0.125911
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency5.007722
pregnane X nuclear receptorHomo sapiens (human)Potency14.759434
pregnane X receptorRattus norvegicus (Norway rat)Potency7.943311
progesterone receptorHomo sapiens (human)Potency0.216911
Rap guanine nucleotide exchange factor 3Homo sapiens (human)Potency100.000011
RAR-related orphan receptor gammaMus musculus (house mouse)Potency31.480624
relaxin receptor 1 isoform 1Homo sapiens (human)Potency0.038811
relaxin receptor 2 isoform 1Homo sapiens (human)Potency0.048811
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency34.081122
retinoid X nuclear receptor alphaHomo sapiens (human)Potency16.806812
TDP1 proteinHomo sapiens (human)Potency17.261323
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency0.036624
thyroid stimulating hormone receptorHomo sapiens (human)Potency0.064047
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency0.004411
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency11.426512

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
5-hydroxytryptamine receptor 1AHomo sapiens (human)IC500.041011
Adenylate cyclase type 1Homo sapiens (human)IC500.095522
ATP-dependent translocase ABCB1Homo sapiens (human)IC50134.200022
nuclear receptor subfamily 0 group B member 1Homo sapiens (human)IC501.729011
steroidogenic factor 1Homo sapiens (human)IC5067.547011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Adenylate cyclase type 1Homo sapiens (human)EC500.500011
Adenylate cyclase type 2Rattus norvegicus (Norway rat)EC502.000011
Adenylate cyclase type 8Homo sapiens (human)EC500.093711
Nuclear receptor subfamily 1 group I member 2Homo sapiens (human)EC506.350044
Nuclear receptor subfamily 1 group I member 2Rattus norvegicus (Norway rat)EC507.100011
Relaxin receptor 1Homo sapiens (human)EC500.047011
Solute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)Kd5.000011