A role played by a chemical compound to induce direct or indirect DNA damage. Such damage can potentially lead to the formation of a malignant tumour, but DNA damage does not lead inevitably to the creation of cancerous cells.
| Member | Definition | Class |
|---|
| 1-naphthol | A naphthol carrying a hydroxy group at position 1. | 1-naphthol |
| 1-pentene-3-one | An enone that is pent-1-ene substituted by an oxo group at position 3. | 1-penten-3-one |
| 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline | An imidazoquinoxaline that is 3H-imidazo[4,5-f]quinoxaline substituted at positions 3 and 8 by methyl groups and at position 2 by an amino group. A mutagenic compound found in cooked beef. | MeIQx |
| 2-anisidine | A substituted aniline that is aniline in which the hydrogen ortho to the amino group has been replaced by a methoxy group. It is used as a chemical intermediate in the synthesis of azo pigments and dyes. | o-anisidine |
| 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine | An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, hydoxyamino, and phenyl groups, respectively. The active metabolite of the dietary carcinogen PhIP. | N-hydroxy-PhIP |
| 2-naphthol | A naphthol carrying a hydroxy group at position 2. | 2-naphthol |
| 2,6-dinitrotoluene | A dinitrotoluene carrying nitro substituents at positions 2 and 6. | 2,6-dinitrotoluene |
| 4-anisidine | A substituted aniline that is aniline in which the hydrogen para to the amino group has been replaced by a methoxy group. It is used as a reagent for the detection of oxidation products such as aldehydes and ketones in fats and oils. | p-anisidine |
| acridines | A polycyclic heteroarene that is anthracene in which one of the central CH groups is replaced by a nitrogen atom. | acridine |
| arsenic trichloride | A arsenic molecular entity that consists of a single arsenic atom bearing three chloro substituents. | arsenic trichloride |
| benzamidoxime | A member of the class of amidoximes obtained by formal condensation of the carbonyl group of benzamide with hydroxylamine. | benzamidoxime |
| benzo(a)pyrene-7,8-dione | An o-quinone resulting from the formal oxidation of both of the hydroxy groups of benzo[a]pyrene-cis-7,8-dihydrodiol. Benzo[a]pyrene-7,8-dione is a metabolite of the widespread carcinogen benzo[a]pyrene. | benzo[a]pyrene-7,8-dione |
| beryllium chloride | A compound of beryllium (+2 oxidation state) and chloride in the ratio 1:2. | beryllium dichloride |
| cadmium nitrate | An inorganic nitrate salt having Cd(2+) as the counterion. | cadmium nitrate |
| camptothecin | A pyranoindolizinoquinoline that is pyrano[3',4':6,7]indolizino[1,2-b]quinoline which is substituted by oxo groups at positions 3 and 14, and by an ethyl group and a hydroxy group at position 4 (the S enantiomer). | camptothecin |
| catechol | A benzenediol comprising of a benzene core carrying two hydroxy substituents ortho to each other. | catechol |
| cisplatin | A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups). | cisplatin; transplatin |
| colibactin | A member of the class of 1,3-thiazoles that comprises of two units of 2-[(2-{6-[(2S)-2-methyl-3,4-dihydro-2H-pyrrol-5-yl]-5-oxo-4-azaspiro[2.4]hept-6-en-7-yl}acetamido)methyl]-1,3-thiazole-4-carboxylic acid linked together via the formal condensation of the carboxy groups. It is a secondary metabolite produced by certain strains of bacteria found in the human gut such as Escherichia coli. It has the ability to bind covalently to DNA and is strongly associated with colorectal cancer. | colibactin |
| ebselen | A benzoselenazole that is 1,2-benzoselenazol-3-one carrying an additional phenyl substituent at position 2. Acts as a mimic of glutathione peroxidase. | ebselen |
| erythropoietin | A dinitronaphthalene carrying nitro groups at positions 1 and 5. | 1,5-dinitronaphthalene |
| estragole | A phenylpropanoid that is chavicol in which the hydroxy group is replaced by a methoxy group. | estragole |
| ethoxyquin | A quinoline that is 1,2-dihydroquinoline bearing three methyl substituents at position 2, 2 and 4 as well as an ethoxy substituent at position 6. | ethoxyquin |
| ethyl methanesulfonate | A methanesulfonate ester resulting from the formal condensation of methanesulfonic acid with ethanol. | ethyl methanesulfonate |
| ethylnitrosourea | A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by ethyl and nitroso groups. | N-ethyl-N-nitrosourea |
| hydrogen sulfide | A sulfur hydride consisting of a single sulfur atom bonded to two hydrogen atoms. A highly poisonous, flammable gas with a characteristic odour of rotten eggs, it is often produced by bacterial decomposition of organic matter in the absence of oxygen. | hydrogen sulfide |
| hydroxyurea | A member of the class of ureas that is urea in which one of the hydrogens is replaced by a hydroxy group. An antineoplastic used in the treatment of chronic myeloid leukaemia as well as for sickle-cell disease. | hydroxyurea |
| imidacloprid | An imidazolidine that is N-nitroimidazolidin-2-imine bearing a (6-chloro-3-pyridinyl)methyl substituent at position 1. | (E)-imidacloprid; (Z)-imidacloprid; imidacloprid |
| imidacloprid | An imidazolidine that is N-nitroimidazolidin-2-imine bearing a (6-chloro-3-pyridinyl)methyl substituent at position 1. | (E)-imidacloprid; (Z)-imidacloprid; imidacloprid |
| imidacloprid | An imidazolidine that is N-nitroimidazolidin-2-imine bearing a (6-chloro-3-pyridinyl)methyl substituent at position 1. | (E)-imidacloprid; (Z)-imidacloprid; imidacloprid |
| methyl methanesulfonate | A methanesulfonate ester resulting from the formal condensation of methanesulfonic acid with methanol. | methyl methanesulfonate |
| methyl parathion | A C-nitro compound that is 4-nitrophenol substituted by a (dimethoxyphosphorothioyl)oxy group at position 4. | parathion-methyl |
| n-dichlorofluoromethylthio-n',n'-dimethyl-n-p-tolylsulfamide | A member of the class of sulfamides that is dichlofluanid in which the hydrogen at the para position of the phenyl group is replaced by a methyl group. A fungicide first marketed in 1971 and used in the cultivation of fruit and vegetables, as well as in wood preservatives, it is no longer approved for use in the European Union. | tolylfluanid |
| paxilline | An indole diterpene alkaloid with formula C27H33NO4 isolated from Penicillium paxilli. It is a potent inhibitor of large conductance Ca2(+)- and voltage-activated K(+) (BK)-type channels. | paxilline |
| riddelliine | A macrodiolide that is 13,19-didehydrosenecionan bearing two additional hydroxy substituents at positions 12 and 18 as well as two additional oxo groups at positions 11 and 16. | riddelliine |
| riddelliine n-oxide | A pyrrolizine alkaloid that is 13,19-didehydrosenecionane bearing two additional hydroxy substituents at positions 12 and 18, two additional oxo groups at positions 11 and 16 and an N-oxido substituent. | riddelliine N-oxide |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 11.1776 | 1 | 14 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 15.7808 | 1 | 8 |
| 2,3-bisphosphoglycerate-independent phosphoglycerate mutase | Leishmania major strain Friedlin | Potency | 7.5686 | 1 | 1 |
| 67.9K protein | Vaccinia virus | Potency | 7.6632 | 2 | 9 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 48.6896 | 4 | 9 |
| acid sphingomyelinase | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 36.9879 | 2 | 10 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 17.4837 | 1 | 20 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 17.6848 | 5 | 14 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 4.4780 | 1 | 3 |
| Amyloid-beta precursor protein | Homo sapiens (human) | Potency | 18.4782 | 1 | 2 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 22.3872 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 31.3540 | 9 | 55 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 34.7606 | 2 | 27 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 6.0829 | 3 | 4 |
| Ataxin-2 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 5.3315 | 3 | 5 |
| atrial natriuretic peptide receptor 1 precursor | Homo sapiens (human) | Potency | 6.7456 | 1 | 1 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 26.1216 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 39.6130 | 2 | 8 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 44.0344 | 1 | 4 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 68.4153 | 1 | 2 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 68.4153 | 1 | 2 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 26.4445 | 2 | 13 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 9.3988 | 2 | 7 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 8.5764 | 1 | 12 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 20.4839 | 1 | 2 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 29.5609 | 2 | 5 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 16.0825 | 2 | 2 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 18.8242 | 1 | 5 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 10.0290 | 2 | 19 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 38.8588 | 1 | 5 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 28.0205 | 2 | 7 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 21.8447 | 3 | 6 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 24.0237 | 1 | 16 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 10.0290 | 2 | 19 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 45.9369 | 2 | 8 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 6.8606 | 1 | 5 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 1.5592 | 1 | 4 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 13.3306 | 1 | 4 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 17.0040 | 2 | 20 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 41.1076 | 1 | 7 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 0.5154 | 1 | 2 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3F isoform a | Homo sapiens (human) | Potency | 33.5520 | 1 | 2 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 21.4865 | 1 | 2 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| DNA polymerase III, partial | Bacillus subtilis | Potency | 11.8160 | 1 | 2 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 54.9432 | 1 | 8 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 53.6538 | 1 | 4 |
| endonuclease IV | Escherichia coli | Potency | 10.6826 | 1 | 2 |
| Endothelin receptor type B | Rattus norvegicus (Norway rat) | Potency | 22.3872 | 1 | 1 |
| Endothelin-1 receptor | Rattus norvegicus (Norway rat) | Potency | 22.3872 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 36.6318 | 12 | 70 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 29.3250 | 3 | 13 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 28.5813 | 9 | 44 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 7.3221 | 1 | 14 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 7.0580 | 4 | 8 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 26.2453 | 3 | 4 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 41.1760 | 2 | 9 |
| fructose-bisphosphate aldolase A | Oryctolagus cuniculus (rabbit) | Potency | 22.3872 | 1 | 1 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 13.1812 | 1 | 2 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 17.0040 | 1 | 10 |
| GALC protein | Homo sapiens (human) | Potency | 0.7079 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 17.0040 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 17.0040 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 17.0040 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 17.0040 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 17.0040 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 17.0040 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 17.0040 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 17.0040 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 17.0040 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 17.0040 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 17.0040 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 17.0040 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 17.0040 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 17.0040 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 17.0040 | 1 | 10 |
| geminin | Homo sapiens (human) | Potency | 13.2862 | 4 | 16 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 25.1822 | 2 | 23 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 14.1254 | 1 | 2 |
| GLS protein | Homo sapiens (human) | Potency | 14.0111 | 2 | 7 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 19.9504 | 1 | 7 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 30.1347 | 4 | 9 |
| glucokinase regulatory protein | Homo sapiens (human) | Potency | 22.8741 | 2 | 2 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 43.1820 | 1 | 7 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | Potency | 18.7108 | 2 | 2 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | Potency | 5.7988 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | Potency | 5.7988 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | Potency | 5.7988 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | Potency | 5.7988 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | Potency | 5.7988 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | Potency | 5.7988 | 1 | 1 |
| guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1 | Homo sapiens (human) | Potency | 7.2923 | 1 | 2 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 13.0918 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 29.6277 | 2 | 6 |
| hemoglobin subunit beta | Homo sapiens (human) | Potency | 0.5025 | 2 | 2 |
| hexokinase-4 isoform 1 | Homo sapiens (human) | Potency | 22.8741 | 2 | 2 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 4.1515 | 2 | 22 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 7.6656 | 1 | 7 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 72.6213 | 2 | 15 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 44.8659 | 1 | 3 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 24.2425 | 1 | 3 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 12.7513 | 4 | 7 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 19.9177 | 2 | 2 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 8.1954 | 2 | 12 |
| IDH1 | Homo sapiens (human) | Potency | 16.5973 | 1 | 3 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 14.2500 | 2 | 2 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 10.7596 | 1 | 3 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 10.7596 | 1 | 3 |
| Interferon beta | Homo sapiens (human) | Potency | 2.0821 | 1 | 3 |
| interleukin 8 | Homo sapiens (human) | Potency | 62.5113 | 1 | 3 |
| isocitrate dehydrogenase 1, partial | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 8.1022 | 2 | 11 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 11.4275 | 1 | 5 |
| lethal(3)malignant brain tumor-like protein 1 isoform I | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 45.5603 | 4 | 14 |
| luciferase | Photuris pensylvanica (Pennsylania firefly) | Potency | 18.0789 | 3 | 5 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 31.3356 | 1 | 7 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 6.7306 | 2 | 12 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 21.6453 | 1 | 3 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 0.1413 | 1 | 1 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 2.8371 | 1 | 2 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 15.0396 | 1 | 3 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 5.6143 | 2 | 8 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 2.1154 | 1 | 2 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 115.8210 | 1 | 1 |
| Nrf2 | Homo sapiens (human) | Potency | 27.4268 | 2 | 5 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 37.0832 | 4 | 32 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 1.2604 | 2 | 2 |
| nuclear factor NF-kappa-B p105 subunit isoform 1 | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 14.9686 | 1 | 3 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 16.8300 | 1 | 3 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 10.0446 | 2 | 17 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 44.5415 | 3 | 36 |
| Ornithine decarboxylase | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 1 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 98.8175 | 1 | 3 |
| Parkin | Homo sapiens (human) | Potency | 20.5962 | 1 | 2 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 47.2562 | 2 | 3 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 28.6954 | 1 | 1 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 48.4819 | 1 | 5 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 34.4776 | 5 | 18 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 25.5538 | 5 | 10 |
| phosphoglycerate kinase | Trypanosoma brucei brucei TREU927 | Potency | 28.4929 | 1 | 2 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 12.1344 | 1 | 5 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 6.1005 | 1 | 4 |
| polyprotein | Zika virus | Potency | 13.1812 | 1 | 2 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 7.3709 | 1 | 4 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 7.2622 | 1 | 5 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| PPM1D protein | Homo sapiens (human) | Potency | 2.0821 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 49.2917 | 2 | 12 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 42.3989 | 1 | 3 |
| progesterone receptor | Homo sapiens (human) | Potency | 38.1601 | 2 | 12 |
| putative alpha-glucosidase | Oryza sativa Japonica Group (Japanese rice) | Potency | 15.8489 | 1 | 1 |
| pyruvate kinase | Leishmania mexicana mexicana | Potency | 15.5513 | 5 | 5 |
| pyruvate kinase PKM isoform a | Homo sapiens (human) | Potency | 5.1189 | 4 | 4 |
| pyruvate kinase PKM isoform b | Homo sapiens (human) | Potency | 10.0000 | 2 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 18.2307 | 2 | 13 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 39.8617 | 1 | 3 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 14.9566 | 1 | 7 |
| relaxin receptor 1 isoform 1 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 47.0001 | 3 | 37 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 25.0894 | 3 | 12 |
| RGS12 | Homo sapiens (human) | Potency | 7.2923 | 1 | 2 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 10.7955 | 3 | 7 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 14.8365 | 1 | 2 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | Potency | 5.7988 | 1 | 1 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 38.7317 | 2 | 4 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 38.7317 | 2 | 4 |
| Smad3 | Homo sapiens (human) | Potency | 21.5227 | 1 | 5 |
| Sodium channel protein type 1 subunit alpha | Rattus norvegicus (Norway rat) | Potency | 5.7988 | 1 | 1 |
| Sodium channel protein type 2 subunit alpha | Rattus norvegicus (Norway rat) | Potency | 5.7988 | 1 | 1 |
| Sodium channel protein type 3 subunit alpha | Rattus norvegicus (Norway rat) | Potency | 5.7988 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 9.7380 | 1 | 7 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 14.3484 | 1 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 9.3728 | 2 | 34 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 49.8808 | 1 | 3 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 19.8388 | 4 | 25 |
| Thrombopoietin | Homo sapiens (human) | Potency | 5.2223 | 2 | 8 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 37.9831 | 3 | 21 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 26.0983 | 6 | 6 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 21.7632 | 6 | 14 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 7.5727 | 1 | 1 |
| transient receptor potential cation channel subfamily V member 1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| tumor susceptibility gene 101 protein | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 6.1005 | 1 | 4 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 6.1005 | 1 | 4 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 34.5488 | 2 | 5 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 36.2529 | 2 | 10 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 30.6314 | 5 | 13 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 28.8972 | 1 | 10 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 43.1820 | 1 | 7 |
| Vpr | Human immunodeficiency virus 1 | Potency | 0.7943 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a | Homo sapiens (human) | IC50 | 2.2555 | 2 | 2 |
| 3-dehydroquinate synthase | Escherichia coli K-12 | Ki | 755.0000 | 2 | 2 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 0.9700 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 0.6170 | 1 | 1 |
| Acetylcholine receptor subunit alpha | Homo sapiens (human) | IC50 | 300.0000 | 1 | 1 |
| Acetylcholine receptor subunit alpha-like 1 | Drosophila melanogaster (fruit fly) | Ki | 0.0021 | 1 | 1 |
| Acetylcholine receptor subunit alpha-like 2 | Drosophila melanogaster (fruit fly) | Ki | 0.0021 | 1 | 1 |
| Acetylcholine receptor subunit beta-like 1 | Drosophila melanogaster (fruit fly) | Ki | 0.0021 | 1 | 1 |
| Acetylcholine receptor subunit beta-like 2 | Drosophila melanogaster (fruit fly) | IC50 | 0.0034 | 2 | 2 |
| Acetylcholine receptor subunit beta-like 2 | Drosophila melanogaster (fruit fly) | Ki | 0.0026 | 2 | 2 |
| Acetylcholine-binding protein | Lymnaea stagnalis (great pond snail) | Ki | 0.9700 | 1 | 1 |
| Acetylcholinesterase | Electrophorus electricus (electric eel) | IC50 | 28.0050 | 2 | 2 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 10.9200 | 2 | 2 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | Ki | 20.6667 | 3 | 3 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | Ki | 381.4500 | 2 | 2 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | IC50 | 2.5080 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 1.1450 | 1 | 1 |
| Angiotensin-converting enzyme 2 | Homo sapiens (human) | IC50 | 0.6700 | 1 | 1 |
| Arginase-1 | Bos taurus (cattle) | IC50 | 123.0000 | 1 | 1 |
| Arrestin, beta 1 | Homo sapiens (human) | IC50 | 1.5240 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Autoinducer 2-binding periplasmic protein LuxP | Vibrio harveyi | IC50 | 59.0000 | 1 | 1 |
| Bifunctional epoxide hydrolase 2 | Homo sapiens (human) | IC50 | 0.7575 | 4 | 4 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 102.7500 | 3 | 4 |
| BZLF2 | Human herpesvirus 4 type 2 (Epstein-Barr virus type 2) | IC50 | 2.0300 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Carbonic anhydrase | Dicentrarchus labrax (European seabass) | Ki | 14.8000 | 1 | 1 |
| Carbonic anhydrase | Methanosarcina thermophila | Ki | 50.0000 | 1 | 1 |
| Carbonic anhydrase | Methanothermobacter thermautotrophicus str. Delta H | Ki | 700.0000 | 1 | 1 |
| Carbonic anhydrase | Stylophora pistillata | Ki | 3,940.0000 | 1 | 1 |
| Carbonic anhydrase | Stylophora pistillata | Ki | 580.0000 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | IC50 | 5.7900 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 1,094.6957 | 18 | 35 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 401.3500 | 3 | 14 |
| Carbonic anhydrase 13 | Mus musculus (house mouse) | Ki | 721.7000 | 4 | 15 |
| Carbonic anhydrase 14 | Homo sapiens (human) | Ki | 407.0643 | 3 | 14 |
| Carbonic anhydrase 15 | Mus musculus (house mouse) | Ki | 10.2000 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | IC50 | 5.7900 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 397.3449 | 20 | 37 |
| Carbonic anhydrase 3 | Bos taurus (cattle) | IC50 | 5.7900 | 1 | 1 |
| Carbonic anhydrase 3 | Bos taurus (cattle) | Ki | 675.5117 | 3 | 6 |
| Carbonic anhydrase 3 | Homo sapiens (human) | Ki | 401.9357 | 3 | 14 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 705.2788 | 9 | 26 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 338.9588 | 6 | 17 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | Ki | 351.8438 | 5 | 16 |
| Carbonic anhydrase 6 | Homo sapiens (human) | IC50 | 5.7900 | 1 | 1 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Ki | 608.3690 | 7 | 21 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 551.2733 | 4 | 15 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 351.5353 | 6 | 17 |
| Carbonic anhydrase, alpha family | Hydrogenovibrio crunogenus XCL-2 | Ki | 1.1000 | 1 | 1 |
| Caspase-1 | Homo sapiens (human) | IC50 | 4.0400 | 1 | 1 |
| Cholinesterase | Equus caballus (horse) | IC50 | 10.4740 | 2 | 2 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 10.1000 | 1 | 2 |
| Cytochrome P450 2A5 | Mus musculus (house mouse) | IC50 | 108.9855 | 2 | 4 |
| Cytochrome P450 2A6 | Homo sapiens (human) | IC50 | 134.9940 | 2 | 4 |
| Deoxyribonuclease-1 | Bos taurus (cattle) | IC50 | 300.0000 | 1 | 1 |
| Deoxyribonuclease-2-alpha | Sus scrofa (pig) | IC50 | 300.0000 | 1 | 1 |
| DNA ligase | Tequatrovirus T4 | IC50 | 300.0000 | 1 | 1 |
| DNA topoisomerase | Bos taurus (cattle) | IC50 | 17.0000 | 1 | 1 |
| DNA topoisomerase 1 | Chlorocebus aethiops (grivet) | IC50 | 27.0000 | 1 | 1 |
| DNA topoisomerase 1 | Homo sapiens (human) | IC50 | 33.2563 | 21 | 22 |
| DNA topoisomerase 1 | Mus musculus (house mouse) | IC50 | 26.0000 | 2 | 2 |
| DNA topoisomerase 2-alpha | Homo sapiens (human) | IC50 | 242.5000 | 3 | 4 |
| E3 ubiquitin-protein ligase Mdm2 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Epidermal growth factor receptor | Homo sapiens (human) | IC50 | 26.0430 | 1 | 1 |
| eukaryotic translation initiation factor 4 gamma 1 isoform 4 | Homo sapiens (human) | IC50 | 1.1500 | 1 | 1 |
| eukaryotic translation initiation factor 4E isoform 1 | Mus musculus (house mouse) | IC50 | 1.1500 | 1 | 1 |
| Forkhead box protein A2-A | Xenopus laevis (African clawed frog) | Ki | 0.0019 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit theta | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-butyrobetaine dioxygenase | Homo sapiens (human) | IC50 | 0.7420 | 5 | 5 |
| glucose-6-phosphate 1-dehydrogenase isoform b | Homo sapiens (human) | IC50 | 13.2000 | 1 | 1 |
| glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | Plasmodium berghei | IC50 | 15.0867 | 3 | 3 |
| Glutaminyl-peptide cyclotransferase | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| hexokinase | Trypanosoma brucei brucei TREU927 | IC50 | 0.9009 | 1 | 1 |
| Histone deacetylase 1 | Homo sapiens (human) | IC50 | 0.0500 | 1 | 1 |
| Histone deacetylase 11 | Homo sapiens (human) | IC50 | 0.0500 | 1 | 1 |
| Histone deacetylase 2 | Homo sapiens (human) | IC50 | 0.0500 | 1 | 1 |
| Histone deacetylase 3 | Homo sapiens (human) | IC50 | 0.0500 | 1 | 1 |
| Histone deacetylase 4 | Homo sapiens (human) | IC50 | 0.0500 | 1 | 1 |
| Histone deacetylase 5 | Homo sapiens (human) | IC50 | 1.7250 | 2 | 2 |
| Histone deacetylase 6 | Homo sapiens (human) | IC50 | 4.9125 | 4 | 4 |
| Histone deacetylase 7 | Homo sapiens (human) | IC50 | 0.0500 | 1 | 1 |
| Histone deacetylase 8 | Homo sapiens (human) | IC50 | 0.0500 | 1 | 1 |
| Histone deacetylase 9 | Homo sapiens (human) | IC50 | 1.8750 | 2 | 2 |
| Histone-lysine N-methyltransferase EHMT1 | Homo sapiens (human) | IC50 | 0.7300 | 1 | 1 |
| Histone-lysine N-methyltransferase EHMT2 | Homo sapiens (human) | IC50 | 0.4000 | 1 | 1 |
| Indoleamine 2,3-dioxygenase 1 | Homo sapiens (human) | Ki | 0.0940 | 3 | 3 |
| Insulin-degrading enzyme | Homo sapiens (human) | IC50 | 33.3520 | 3 | 3 |
| Integrase | Human immunodeficiency virus 1 | IC50 | 100.0000 | 1 | 1 |
| large T antigen | Betapolyomavirus macacae | IC50 | 13.9100 | 1 | 1 |
| Liver carboxylesterase B-1 | Rattus norvegicus (Norway rat) | IC50 | 14.0000 | 1 | 1 |
| Macrophage migration inhibitory factor | Homo sapiens (human) | IC50 | 2.4000 | 1 | 1 |
| Macrophage migration inhibitory factor | Homo sapiens (human) | Ki | 0.5700 | 2 | 2 |
| MAP kinase-activated protein kinase 2 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Matrix metalloproteinase-9 | Homo sapiens (human) | IC50 | 23.3670 | 1 | 1 |
| Methionine aminopeptidase 2 | Homo sapiens (human) | IC50 | 2.4300 | 1 | 1 |
| MPI protein | Homo sapiens (human) | IC50 | 0.2905 | 2 | 2 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 70.2000 | 1 | 2 |
| Muscarinic acetylcholine receptor DM1 | Drosophila melanogaster (fruit fly) | Ki | 100.0000 | 2 | 2 |
| Neuronal acetylcholine receptor subunit alpha-3 | Homo sapiens (human) | IC50 | 14.0000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-4 | Gallus gallus (chicken) | IC50 | 2.6000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-4 | Mus musculus (house mouse) | IC50 | 2.6000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-4 | Gallus gallus (chicken) | Ki | 0.9700 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-4 | Homo sapiens (human) | Ki | 0.7200 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Ki | 0.0500 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-7 | Homo sapiens (human) | IC50 | 270.0000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-2 | Homo sapiens (human) | Ki | 0.7200 | 1 | 1 |
| neutrophil cytosol factor 1 | Homo sapiens (human) | IC50 | 0.3900 | 1 | 1 |
| Neutrophil cytosol factor 1 | Homo sapiens (human) | Ki | 125.0000 | 3 | 3 |
| Nicotinic acetyl choline receptor alpha-subunit | Myzus persicae (green peach aphid) | Ki | 0.0019 | 1 | 1 |
| Nicotinic acetylcholine receptor | Drosophila melanogaster (fruit fly) | Ki | 0.0021 | 1 | 1 |
| Nicotinic acetylcholine receptor alpha 3 subunit | Myzus persicae (green peach aphid) | Ki | 0.0019 | 1 | 1 |
| Nicotinic acetylcholine receptor alpha 4 subunit | Myzus persicae (green peach aphid) | Ki | 0.0019 | 1 | 1 |
| Nicotinic acetylcholine receptor alpha 5 subunit | Musca domestica (house fly) | Ki | 0.0046 | 1 | 1 |
| Nicotinic acetylcholine receptor alpha3, isoform B | Drosophila melanogaster (fruit fly) | Ki | 0.0021 | 1 | 1 |
| Nicotinic acetylcholine receptor alpha4, isoform D | Drosophila melanogaster (fruit fly) | Ki | 0.0021 | 1 | 1 |
| Nicotinic acetylcholine receptor alpha5, isoform B | Drosophila melanogaster (fruit fly) | Ki | 0.0021 | 1 | 1 |
| Nicotinic acetylcholine receptor alpha6, isoform E | Drosophila melanogaster (fruit fly) | Ki | 0.0021 | 1 | 1 |
| Nicotinic acetylcholine receptor beta 3 | Drosophila melanogaster (fruit fly) | Ki | 0.0021 | 1 | 1 |
| Nicotinic acetylcholine receptor Dalpha7 | Drosophila melanogaster (fruit fly) | Ki | 0.0021 | 1 | 1 |
| Nicotinic acetylcholine receptor, alpha5 subunit | Myzus persicae (green peach aphid) | Ki | 0.0019 | 1 | 1 |
| Nicotinic acetylcholine receptor, alpha7-1 subunit | Myzus persicae (green peach aphid) | Ki | 0.0019 | 1 | 1 |
| Nicotinic acetylcholine receptor, alpha7-2 subunit | Myzus persicae (green peach aphid) | Ki | 0.0019 | 1 | 1 |
| perilipin-1 | Homo sapiens (human) | IC50 | 3.4100 | 1 | 1 |
| perilipin-5 | Homo sapiens (human) | IC50 | 1.1010 | 1 | 1 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Homo sapiens (human) | IC50 | 33.0000 | 1 | 1 |
| phosphoethanolamine/phosphocholine phosphatase isoform 1 | Homo sapiens (human) | IC50 | 0.1110 | 1 | 1 |
| phosphomannomutase 2 | Homo sapiens (human) | IC50 | 0.6720 | 1 | 1 |
| Polyamine deacetylase HDAC10 | Homo sapiens (human) | IC50 | 0.0500 | 1 | 1 |
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 1,000.0000 | 1 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase | Rattus norvegicus (Norway rat) | IC50 | 3.6000 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | IC50 | 1.4580 | 1 | 2 |
| Procathepsin L | Homo sapiens (human) | IC50 | 0.6700 | 1 | 1 |
| Prolyl 4-hydroxylase subunit alpha-1 | Gallus gallus (chicken) | Ki | 25.0000 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | IC50 | 3.1520 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Bos taurus (cattle) | IC50 | 2.0500 | 2 | 2 |
| Prostaglandin G/H synthase 2 | Bos taurus (cattle) | IC50 | 2.0000 | 1 | 1 |
| Putative nicotinic acetylcholine receptor subunit | Myzus persicae (green peach aphid) | Ki | 0.0019 | 1 | 1 |
| Replicase polyprotein 1a | Severe acute respiratory syndrome-related coronavirus | IC50 | 0.6700 | 1 | 1 |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | IC50 | 5.3350 | 2 | 2 |
| Replicase polyprotein 1ab | Human coronavirus 229E | IC50 | 0.6700 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 0.7928 | 13 | 14 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | IC50 | 0.6200 | 2 | 3 |
| Ribonuclease pancreatic | Bos taurus (cattle) | IC50 | 300.0000 | 1 | 1 |
| Ribonucleoside-diphosphate reductase large subunit | Homo sapiens (human) | IC50 | 997.0000 | 1 | 1 |
| RNA polymerase beta subunit (EC 2.7.7.6), partial | Escherichia coli | IC50 | 11.6872 | 1 | 1 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | Oryctolagus cuniculus (rabbit) | IC50 | 5.0000 | 1 | 1 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Soluble acetylcholine receptor | Aplysia californica (California sea hare) | Ki | 0.0190 | 1 | 1 |
| Somatostatin receptor type 1 | Homo sapiens (human) | IC50 | 0.0022 | 1 | 1 |
| Somatostatin receptor type 2 | Homo sapiens (human) | IC50 | 0.0022 | 1 | 1 |
| Somatostatin receptor type 3 | Homo sapiens (human) | IC50 | 0.0022 | 1 | 1 |
| Somatostatin receptor type 4 | Homo sapiens (human) | IC50 | 0.0022 | 1 | 1 |
| Somatostatin receptor type 5 | Homo sapiens (human) | IC50 | 0.0022 | 1 | 1 |
| Spike glycoprotein | Betacoronavirus England 1 | IC50 | 0.6700 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | IC50 | 0.6700 | 1 | 1 |
| Structural capsid protein | Human immunodeficiency virus 1 | IC50 | 0.0467 | 1 | 1 |
| Sulfhydryl oxidase 1 | Homo sapiens (human) | IC50 | 5.4000 | 1 | 1 |
| Telomerase reverse transcriptase | Homo sapiens (human) | IC50 | 300.0000 | 1 | 1 |
| Toxin B | Clostridioides difficile | IC50 | 0.0172 | 1 | 1 |
| TPA: protein transporter TIM10 | Saccharomyces cerevisiae S288C | IC50 | 14.7100 | 2 | 3 |
| TPA: protein transporter TIM23 | Saccharomyces cerevisiae S288C | IC50 | 0.8800 | 1 | 1 |
| Transmembrane protease serine 2 | Homo sapiens (human) | IC50 | 0.6700 | 1 | 1 |
| Type-2 restriction enzyme BamHI | Bacillus amyloliquefaciens | IC50 | 300.0000 | 1 | 1 |
| Type-2 restriction enzyme EcoRI | Escherichia coli | IC50 | 300.0000 | 1 | 1 |
| Type-2 restriction enzyme HindIII | Haemophilus influenzae Rd KW20 | IC50 | 300.0000 | 1 | 1 |
| Type-2 restriction enzyme PstI | Providencia stuartii | IC50 | 300.0000 | 1 | 1 |
| Type-2 restriction enzyme ScaI | Streptomyces caespitosus | IC50 | 300.0000 | 1 | 1 |
| Tyrosine-protein kinase Fyn | Homo sapiens (human) | IC50 | 17.4310 | 1 | 1 |
| Tyrosyl-DNA phosphodiesterase 1 | Homo sapiens (human) | IC50 | 111.0000 | 1 | 1 |
| Tyrosyl-DNA phosphodiesterase 2 | Homo sapiens (human) | IC50 | 111.0000 | 1 | 1 |
| UDP-glucose 4-epimerase | Homo sapiens (human) | IC50 | 0.0140 | 1 | 1 |
| UDP-glucuronosyltransferase 1A1 | Homo sapiens (human) | IC50 | 260.0000 | 2 | 2 |
| Urease subunit alpha | Helicobacter pylori 26695 | IC50 | 44.3780 | 5 | 5 |
| Urease subunit alpha | Helicobacter pylori 26695 | Ki | 0.2260 | 1 | 1 |
| Urease subunit beta | Helicobacter pylori 26695 | IC50 | 44.3780 | 5 | 5 |
| Urease subunit beta | Helicobacter pylori 26695 | Ki | 0.2260 | 1 | 1 |