An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that interferes with the action of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (EC 1.1.1.267).
ChEBI ID: 77654
| Member | Definition | Class |
|---|---|---|
| fosmidomycin | Propylphosphonic acid in which one of the hydrogens at position 3 is substituted by a formyl(hydroxy)amino group. An antibiotic obtained from Streptomyces lavendulae, it specifically inhibits DXP reductoisomerase (EC 1.1.1.267), a key enzyme in the non-mevalonate pathway of isoprenoid biosynthesis. | fosmidomycin |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 16 (6.81) | 18.7374 |
| 1990's | 3 (1.28) | 18.2507 |
| 2000's | 92 (39.15) | 29.6817 |
| 2010's | 109 (46.38) | 24.3611 |
| 2020's | 15 (6.38) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 10 (4.12%) | 5.53% |
| Reviews | 20 (8.23%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 213 (87.65%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 1-deoxy-D-xylulose 5-phosphate reductoisomerase | Escherichia coli K-12 | IC50 | 231.6542 | 8 | 8 |
| 1-deoxy-D-xylulose 5-phosphate reductoisomerase | Mycobacterium tuberculosis H37Rv | IC50 | 0.1650 | 6 | 6 |
| 1-deoxy-D-xylulose 5-phosphate reductoisomerase | Mycolicibacterium smegmatis MC2 155 | IC50 | 0.2950 | 2 | 2 |
| 1-deoxy-D-xylulose 5-phosphate reductoisomerase | Mycobacterium tuberculosis H37Rv | Ki | 0.1400 | 1 | 1 |
| 1-deoxy-D-xylulose 5-phosphate reductoisomerase | Synechocystis sp. PCC 6803 substr. Kazusa | Ki | 0.0210 | 1 | 1 |
| 1-deoxy-D-xylulose 5-phosphate reductoisomerase | Escherichia coli | IC50 | 0.4380 | 1 | 1 |
| 1-deoxy-D-xylulose 5-phosphate reductoisomerase, chloroplastic | Arabidopsis thaliana (thale cress) | IC50 | 0.1000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 1-deoxy-D-xylulose 5-phosphate reductoisomerase | Mycobacterium tuberculosis H37Rv | Kd | 0.0400 | 1 | 1 |