Thoracic Outlet Syndrome

A neurovascular syndrome associated with compression of the BRACHIAL PLEXUS; SUBCLAVIAN ARTERY; and SUBCLAVIAN VEIN at the superior thoracic outlet. This may result from a variety of anomalies such as a CERVICAL RIB, anomalous fascial bands, and abnormalities of the origin or insertion of the anterior or medial scalene muscles. Clinical features may include pain in the shoulder and neck region which radiates into the arm, PARESIS or PARALYSIS of brachial plexus innervated muscles, PARESTHESIA, loss of sensation, reduction of arterial pulses in the affected extremity, ISCHEMIA, and EDEMA. (Adams et al., Principles of Neurology, 6th ed, pp214-5).

Synonym
Thoracic Outlet Syndrome

Excerpt	Reference
"Thoracic outlet syndrome are often difficult to diagnose on existing clinical and electrophysiological criteria and new diagnostic methods are necessary."	( Donaghy, M; Gibson, R; Moore, N; Panegyres, PK; Rushworth, G, 1993)
"Neurogenic thoracic outlet syndrome is an underestimated cause of brachial weakness and pain."	( El-Koussy, MM; Kaelin-Lang, A; Muellner, J; Pfeiffer, O, 2015)

Excerpt	Reference
"To assess the outcome of surgical treatment for thoracic outlet syndrome (TOS), and to compare the outcome in patients with and without an underlying cervical rib."	( Donaghy, M; Matkovic, Z; Morris, P, 1999)
"In this paper the surgical treatment of thoracic outlet syndrome (TOS) is presented."	( Korta, K; Pupka, A; Ruciński, A; Rybak, Z; Szyber, P; Zacharska, S, 2006)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	55 (37.16)	23.3326
1990's	21 (14.19)	12.5806
2000's	19 (12.84)	18.1394
2010's	38 (25.68)	28.8240
2020's	15 (10.14)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	1	0
5-hydroxytryptophan	low	1	0
carbamates	low	1	0
salicylic acid	low	1	0
hydrogen sulfide	low	1	0
hydrogen carbonate	low	1	0
dalteparin	low	1	0
pyridoxine	low	1	0
thiamine	low	2	0
diatrizoic acid	low	1	0
aspirin	low	2	0
bupivacaine	low	1	0
caffeine	low	1	0
chlordiazepoxide	low	1	0
chlormezanone	low	1	0
diazepam	low	2	0
dicyclomine	low	1	0
doxylamine	low	1	0
etidronate	low	1	0
gabapentin	low	1	0
ibuprofen	low	1	0
lidocaine	low	10	0
iothalamic acid	low	1	0
methocarbamol	low	1	0
orphenadrine	low	1	0
phenylbutazone	low	2	0
procaine	low	5	0
prednisolone	low	1	0
reserpine	low	1	0
sorbitol	low	1	0
aminopyrine	low	1	0
meglumine	low	1	0
iodinated glycerol	low	1	0
gadolinium	low	3	0
trolamine salicylate	low	3	0
fomesafen	low	1	0
fluorodeoxyglucose f18	low	1	0
bosentan anhydrous	low	1	0
ropivacaine	medium	3	2
fibrin	low	2	0
bradykinin	low	1	0
iothalamate meglumine	low	1	0
nitinol	low	3	0
alprostadil	low	1	0
morphine	medium	3	1
nitrofurantoin	low	1	0
gadolinium dtpa	low	4	0
apixaban	low	1	0
indocyanine green	low	2	0
gadofosveset trisodium	low	1	0
ascorbic acid	low	1	0
salicylates	low	1	0
warfarin	low	3	0
vitamin b 12	low	2	0
sildenafil citrate	low	1	0
eye	low	1	0

Protein Targets (642)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
TDP1 protein	12	0	0	12
AR protein	20	0	0	20
glucocorticoid receptor [Homo sapiens]	16	0	0	16
estrogen nuclear receptor alpha	23	0	0	23
peroxisome proliferator activated receptor gamma	11	0	0	11
ATP-binding cassette sub-family C member 3	0	13	0	13
Multidrug resistance-associated protein 4	0	13	0	14
Bile salt export pump	0	26	0	26
Cellular tumor antigen p53	12	0	0	12
Thromboxane-A synthase	0	2	0	2
Prostaglandin E2 receptor EP3 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	2	0	2
Prostacyclin receptor	0	1	1	2
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Canalicular multispecific organic anion transporter 1	0	12	0	12
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier organic anion transporter family member 2B1	0	1	0	1
Solute carrier organic anion transporter family member 3A1	0	0	0	1
Chain A, Ferritin light chain	2	0	0	2
Luciferase	7	0	0	7
interleukin 8	4	0	0	4
thioredoxin reductase	10	0	0	10
15-lipoxygenase, partial	2	0	0	2
RAR-related orphan receptor gamma	16	0	0	16
GLS protein	9	0	0	9
GLI family zinc finger 3	14	0	0	14
thyroid stimulating hormone receptor	9	0	0	9
estrogen receptor 2 (ER beta)	6	0	0	6
nuclear receptor subfamily 1, group I, member 3	8	0	0	8
cytochrome P450 family 3 subfamily A polypeptide 4	15	0	0	15
retinoic acid nuclear receptor alpha variant 1	12	0	0	12
retinoid X nuclear receptor alpha	9	0	0	9
estrogen-related nuclear receptor alpha	17	0	0	17
pregnane X nuclear receptor	13	0	0	13
G	10	0	0	10
peroxisome proliferator-activated receptor delta	6	0	0	6
vitamin D (1,25- dihydroxyvitamin D3) receptor	14	0	0	14
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	7	0	0	7
activating transcription factor 6	6	0	0	6
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	5	0	0	5
v-jun sarcoma virus 17 oncogene homolog (avian)	5	0	0	5
chromobox protein homolog 1	9	0	0	9
thyroid hormone receptor beta isoform a	7	0	0	7
thyroid hormone receptor beta isoform 2	10	0	0	10
histone deacetylase 9 isoform 3	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	9	0	0	9
geminin	12	0	0	12
lamin isoform A-delta10	16	0	0	16
Voltage-dependent calcium channel gamma-2 subunit	8	0	0	8
Interferon beta	12	0	0	12
HLA class I histocompatibility antigen, B alpha chain	10	0	0	10
Glutamate receptor 2	8	0	0	8
Nicotinate phosphoribosyltransferase	0	5	0	5
Inositol hexakisphosphate kinase 1	10	0	0	10
cytochrome P450 2C9, partial	10	0	0	10
ORF73	0	0	1	1
Chain A, Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Stuart-Prower factor)	0	1	0	1
EWS/FLI fusion protein	7	0	0	7
Coagulation factor X	0	1	0	1
Prothrombin	0	1	0	1
Coagulation factor X	0	2	0	2
Trypsin-1	0	1	0	1
Trypsin-2	0	1	0	1
Trypsin-3	0	1	0	1
Spike glycoprotein	5	0	0	5
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	3	0	0	3
thioredoxin glutathione reductase	3	0	0	3
IDH1	8	0	0	8
euchromatic histone-lysine N-methyltransferase 2	16	0	0	16
nuclear factor erythroid 2-related factor 2 isoform 2	3	0	0	3
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
lethal factor (plasmid)	5	0	0	5
Polyphenol oxidase 2	0	2	0	3
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	2	0	2
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	2	1	3
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	6	0	0	6
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	4	0	0	4
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	6	0	0	6
Chain B, HADH2 protein	6	0	0	6
Chain A, 2-oxoglutarate Oxygenase	8	0	0	8
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
aldehyde dehydrogenase 1 family, member A1	8	0	0	8
hypothetical protein, conserved	1	0	0	1
cytochrome P450 2D6	5	0	0	5
glucocerebrosidase	3	0	0	3
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
Bloom syndrome protein isoform 1	6	0	0	6
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	5	0	0	5
DNA polymerase iota isoform a (long)	7	0	0	7
DNA polymerase kappa isoform 1	5	0	0	5
muscarinic acetylcholine receptor M1	8	0	0	8
Prostaglandin-H2 D-isomerase	0	2	0	2
Solute carrier family 22 member 6	0	4	0	4
Prostaglandin G/H synthase 1	0	3	0	4
Prostaglandin G/H synthase 2	0	3	0	4
Epidermal growth factor receptor	0	3	0	3
Carbonic anhydrase 1	0	8	0	9
Carbonic anhydrase 2	0	8	0	9
Fatty acid-binding protein, liver	0	4	0	4
Integrin beta-3	0	1	0	1
Myeloperoxidase	0	1	0	1
Prostaglandin G/H synthase 1	0	6	0	7
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	0	1	0	1
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	6	0	6
Adenosine receptor A1	0	5	0	6
Adenosine receptor A2a	0	5	0	7
Substance-P receptor	0	3	0	3
Prostaglandin G/H synthase 2	0	8	1	9
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	2	0	2
Nuclear receptor ROR-gamma	4	0	0	4
Ras-related protein Rab-2A	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	5	6	2	13
Prostaglandin G/H synthase 2	0	5	0	5
Rho-associated protein kinase 2	0	2	0	2
Solute carrier family 22 member 20	0	3	0	3
Solute carrier family 22 member 6	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	5	1	6
Sigma non-opioid intracellular receptor 1	0	1	1	2
phosphopantetheinyl transferase	4	0	0	4
progesterone receptor	9	0	0	9
vitamin D3 receptor isoform VDRA	4	0	0	4
heat shock protein beta-1	2	0	0	2
nuclear receptor ROR-gamma isoform 1	3	0	0	3
Bile salt export pump	0	6	0	6
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Endothelin receptor type B	0	1	0	1
Endothelin receptor type B	0	2	1	3
Endothelin-1 receptor	0	2	0	2
Endothelin-1 receptor	0	2	1	3
Endothelin receptor type B	0	0	1	1
Deoxyhypusine synthase	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Endothelin-1 receptor	0	1	0	1
histone acetyltransferase KAT2A isoform 1	6	0	0	6
Angiotensin-converting enzyme	0	0	0	1
B2 bradykinin receptor	0	1	0	1
B2 bradykinin receptor	0	2	1	5
B1 bradykinin receptor	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Potassium channel subfamily K member 3	0	3	0	3
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	2	3
Potassium channel subfamily K member 9	0	1	0	1
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	2	2
Chain A, glycogen phosphorylase, liver form	0	0	2	2
Chain A, Glycogen phosphorylase, liver form	0	0	2	2
Chain A, Glycogen phosphorylase, liver form	0	0	2	2
Chain A, Chitinase	0	1	0	1
farnesoid X nuclear receptor	5	0	0	5
thyroid stimulating hormone receptor	4	0	0	4
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
DNA polymerase beta	2	0	0	2
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	1	0	1
Cholinesterase	0	2	0	2
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Adenosine receptor A3	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Amine oxidase [flavin-containing] A	0	2	0	2
Acetylcholinesterase	0	3	0	3
Amine oxidase [flavin-containing] B	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	2	1	4
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2b	0	2	0	3
Adenosine receptor A1	0	1	1	4
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	2	3
Endochitinase B1	0	1	0	1
Muscarinic acetylcholine receptor	0	0	0	1
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	2
Guanine deaminase	0	2	0	2
ATP-dependent phosphofructokinase	5	0	0	5
glp-1 receptor, partial	4	0	0	4
potassium voltage-gated channel subfamily H member 2 isoform d	5	0	0	5
Gamma-aminobutyric acid receptor subunit pi	5	5	1	11
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	4	3	7
Gamma-aminobutyric acid receptor subunit beta-1	5	5	1	11
Translocator protein	0	2	2	5
Gamma-aminobutyric acid receptor subunit delta	5	5	1	11
Gamma-aminobutyric acid receptor subunit gamma-2	0	4	2	6
Gamma-aminobutyric acid receptor subunit gamma-2	5	5	2	12
5-hydroxytryptamine receptor 1A	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-5	5	5	1	11
Gamma-aminobutyric acid receptor subunit alpha-3	5	5	1	11
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-1	5	5	1	11
Gamma-aminobutyric acid receptor subunit alpha-2	5	5	1	11
Gamma-aminobutyric acid receptor subunit alpha-4	5	5	1	11
Gamma-aminobutyric acid receptor subunit beta-3	0	4	2	6
Gamma-aminobutyric acid receptor subunit gamma-3	5	5	1	11
Gamma-aminobutyric acid receptor subunit alpha-6	5	5	1	11
Cholecystokinin receptor type A	0	2	0	2
Gastrin/cholecystokinin type B receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	4	3	7
Gamma-aminobutyric acid receptor subunit alpha-3	0	4	2	6
Histamine H1 receptor	0	5	0	5
Gamma-aminobutyric acid receptor subunit alpha-2	0	4	2	6
Gamma-aminobutyric acid receptor subunit beta-3	5	5	1	11
Gamma-aminobutyric acid receptor subunit beta-2	5	5	2	12
GABA theta subunit	5	5	1	11
Gamma-aminobutyric acid receptor subunit epsilon	5	5	1	11
arylsulfatase A	6	0	0	6
peripheral myelin protein 22 isoform 1	3	0	0	3
M-phase phosphoprotein 8	4	0	0	4
Gamma-aminobutyric acid	0	1	1	2
Gamma-aminobutyric acid receptor subunit pi	0	3	0	3
Gamma-aminobutyric acid receptor subunit delta	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Alpha-1-acid glycoprotein 1	0	0	0	1
Albumin	0	3	4	8
Albumin	0	0	3	3
ATP-dependent translocase ABCB1	0	5	0	6
Neuronal acetylcholine receptor subunit alpha-4	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	3	1	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit delta	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	1	2
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	3	2	5
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	1	4
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit epsilon	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit pi	0	1	1	2
Sphingosine-1-phosphate lyase 1	0	1	0	1
ATPase family AAA domain-containing protein 5	4	0	0	4
Ataxin-2	5	0	0	5
Gamma-aminobutyric acid receptor subunit gamma-3	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Gamma-aminobutyric acid receptor subunit theta	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit theta	0	3	0	3
SMAD family member 2	5	0	0	5
ATAD5 protein, partial	4	0	0	4
SMAD family member 3	5	0	0	5
Thrombopoietin	2	0	0	2
caspase 7, apoptosis-related cysteine protease	2	0	0	2
caspase-3	2	0	0	2
Histone H2A.x	2	0	0	2
Caspase-7	1	0	0	1
cytochrome P450 2D6 isoform 1	3	0	0	3
cytochrome P450 2C9 precursor	3	0	0	3
D(1A) dopamine receptor	3	0	0	3
caspase-3	1	0	0	1
cytochrome P450 3A4 isoform 1	5	0	0	5
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
5-hydroxytryptamine receptor 4	0	4	0	4
Muscarinic acetylcholine receptor M2	0	4	0	4
Muscarinic acetylcholine receptor M4	0	4	0	4
Muscarinic acetylcholine receptor M5	0	4	0	4
Muscarinic acetylcholine receptor M1	0	4	0	4
Angiotensin-converting enzyme	0	2	0	2
Muscarinic acetylcholine receptor M3	0	4	0	4
Histamine H2 receptor	0	4	0	4
5-hydroxytryptamine receptor 2A	0	5	0	5
5-hydroxytryptamine receptor 2C	0	4	0	4
D(3) dopamine receptor	0	3	0	3
5-hydroxytryptamine receptor 2B	0	4	0	4
Histamine H2 receptor	3	0	0	3
5-hydroxytryptamine receptor 6	0	4	0	4
Potassium voltage-gated channel subfamily H member 2	0	7	0	7
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
flap endonuclease 1	4	0	0	4
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
acid sphingomyelinase	1	0	0	1
apical membrane antigen 1, AMA1	1	0	0	1
Type IV secretion-like conjugative transfer relaxase protein TraI	0	1	0	1
aryl hydrocarbon receptor	7	0	0	7
peripheral myelin protein 22	6	0	0	6
Solute carrier family 22 member 1	0	4	0	5
D(2) dopamine receptor	0	1	0	1
D(4) dopamine receptor	0	1	0	1
Delta-type opioid receptor	0	3	0	4
Delta-type opioid receptor	0	4	1	6
Mu-type opioid receptor	0	4	2	9
Kappa-type opioid receptor	0	3	1	5
Mu-type opioid receptor	0	6	2	9
Delta-type opioid receptor	0	4	1	6
Kappa-type opioid receptor	0	4	0	4
Kappa-type opioid receptor	0	4	1	6
Mu-type opioid receptor	0	3	1	6
Mu-type opioid receptor	0	5	0	5
Sigma non-opioid intracellular receptor 1	0	2	0	2
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
USP1 protein, partial	6	0	0	6
regulator of G-protein signaling 4	5	0	0	5
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
survival motor neuron protein isoform d	5	0	0	5
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	1	1
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
transcriptional regulator ERG isoform 3	2	0	0	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
neuropeptide S receptor isoform A	4	0	0	4
Histone deacetylase 3	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 2	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Histone deacetylase 4	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
TAR DNA-binding protein 43	4	0	0	4
Histone deacetylase 1	0	1	0	1
Sterol O-acyltransferase 1	0	0	1	1
Proton-coupled amino acid transporter 1	0	1	0	1
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Histone deacetylase 8	0	1	0	1
Platelet glycoprotein VI	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Histone deacetylase 6	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 1	0	0	1	1
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Carbonic anhydrase 4	0	3	0	4
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase 15	0	2	0	2
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 6	0	3	0	4
Carbonic anhydrase 5A, mitochondrial	0	2	0	3
Carbonic anhydrase 7	0	2	0	3
Carbonic anhydrase 9	0	2	0	3
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Carbonic anhydrase 13	0	2	0	3
Carbonic anhydrase 5B, mitochondrial	0	2	0	3
NFKB1 protein, partial	1	0	0	1
nonstructural protein 1	3	0	0	3
67.9K protein	2	0	0	2
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
muscleblind-like protein 1 isoform 1	4	0	0	4
Acid-sensing ion channel 3	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Cytochrome P450 2C9	0	5	0	5
Fatty acid-binding protein, intestinal	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	4
UDP-glucuronosyltransferase 2B7	0	0	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Caspase-1	0	1	0	2
Prostaglandin G/H synthase 2	0	3	0	4
UDP-glucuronosyltransferase 1A3	0	0	0	2
Aldo-keto reductase family 1 member C3	0	3	0	3
Caspase-3	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Caspase-4	0	1	0	1
Cytochrome P450 2J2	0	2	0	2
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Acid-sensing ion channel 1	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	3
Solute carrier family 22 member 6	0	3	0	4
Prostaglandin G/H synthase 1	0	3	0	4
Solute carrier family 22 member 8	0	5	0	5
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
Chain A, Cruzipain	1	0	0	1
Microtubule-associated protein tau	5	0	0	5
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
Parkin	2	0	0	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
ras-related protein Rab-9A	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
Prostaglandin E synthase	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	2	0	2
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Cytochrome c oxidase subunit 2	0	1	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Procathepsin L	0	1	0	1
Interleukin-8	0	1	0	1
Androgen receptor	0	2	1	3
Aldo-keto reductase family 1 member B1	0	2	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Nitric oxide synthase, inducible	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
C-X-C chemokine receptor type 3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Guanine nucleotide-binding protein G	1	0	0	1
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	1	0	1
Lactoylglutathione lyase	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Solute carrier family 22 member 7	0	0	0	2
Sigma intracellular receptor 2	0	1	0	1
Multidrug and toxin extrusion protein 1	0	3	0	3
Dehydrogenase/reductase SDR family member 9	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	2
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
Solute carrier organic anion transporter family member 1B1	0	2	0	2
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
Chain A, Beta-lactamase	4	0	0	4
mitogen-activated protein kinase 1	3	0	0	3
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Phosphodiesterase	0	1	0	1
cytochrome P450 2C19 precursor	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
Vpr	1	0	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Aurora kinase A	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	2	0	2
Dual specificity protein kinase TTK	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	2	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	2	0	2
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Aurora kinase B	0	1	0	1
Inner centromere protein	0	1	0	1
Phosphodiesterase	0	1	0	1
Opioid receptor, delta 1b	0	1	0	1
Acetylcholinesterase	0	1	0	1
Opioid receptor homologue	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Acyl-CoA desaturase 1	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Cytochrome P450 3A4	0	1	1	2
Muscarinic acetylcholine receptor M5	0	1	0	1
Alpha-2A adrenergic receptor	0	2	1	3
Muscarinic acetylcholine receptor M2	0	1	0	1
Histidine decarboxylase	0	0	1	1
ATP-dependent translocase ABCB1	0	2	0	2
Proteinase-activated receptor 1	0	1	1	2
Sodium-dependent serotonin transporter	0	1	0	1
Kappa-type opioid receptor	0	2	1	4
Nociceptin receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	2	0	2
Mu-type opioid receptor	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Mu-type opioid receptor	0	1	0	1
streptokinase A precursor	0	0	1	1
Estrogen receptor	0	0	1	1
Caspase-7	2	0	0	2
60 kDa chaperonin	0	1	0	1
Estrogen receptor beta	0	0	1	1
10 kDa chaperonin	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Smad3	1	0	0	1
Solute carrier family 22 member 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Cytochrome P450 2D6	0	1	0	1
Sodium-dependent noradrenaline transporter	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
pregnane X receptor	1	0	0	1
Estrogen receptor 1	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
fMet-Leu-Phe receptor	0	1	0	1
Cyclooxygenase-2	0	1	0	1
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Glucocorticoid receptor	0	2	1	8
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glycine receptor subunit alpha-1	0	2	0	2
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Androgen receptor	0	1	0	1
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Pyridoxal kinase	0	0	0	1
endonuclease IV	1	0	0	1
hemoglobin subunit beta	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
caspase-1 isoform alpha precursor	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Quinolone resistance protein NorA	0	1	0	2
DNA topoisomerase 1	0	1	0	1
Chromaffin granule amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	2	1	3
Synaptic vesicular amine transporter	0	1	0	1
Solute carrier family 22 member 1	0	2	0	2
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, 146aa long hypothetical transcriptional regulator	0	0	1	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain B, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain C, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Anthranilate phosphoribosyltransferase	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Carbonic anhydrase 12	0	1	0	2
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Carbonic anhydrase 3	0	1	0	2
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
Carbonic anhydrase 14	0	1	0	2
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
Solute carrier family 22 member 2	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
PPM1D protein	1	0	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Treatment

Research

Studies (148)

Protein Targets (642)

Thoracic Outlet Syndrome

Synonyms(1)

Research Excerpts

Overview

Treatment

Research

Studies (148)

Drugs Studied (67)

Protein Targets (642)