Roles > tranquilizing drug
Page last updated: 2024-08-05 15:17:10

tranquilizing drug

A traditional grouping of drugs said to have a soothing or calming effect on mood, thought or behaviour.

ChEBI ID: 35473

Members (2)

MemberDefinitionClass
carfentanilA monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of methyl 4-anilino-1-(2-phenylethyl)piperidine-4-carboxylate with propanoic acid.carfentanil
cyclobenzaprine5-Methylidene-5H-dibenzo[a,d]cycloheptene in which one of the hydrogens of the methylidene group is substituted by a 2-(dimethylamino)ethyl group. A centrally acting skeletal muscle relaxant, it is used as its hydrochloride salt in the symptomatic treatment of painful muscle spasm.cyclobenzaprine

Research

Studies (467)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-199069 (14.78)18.7374
1990's63 (13.49)18.2507
2000's94 (20.13)29.6817
2010's178 (38.12)24.3611
2020's63 (13.49)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials73 (14.54%)5.53%
Reviews34 (6.77%)6.00%
Case Studies62 (12.35%)4.05%
Observational0 (0.00%)0.25%
Other333 (66.33%)84.16%

Protein Targets (35)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-lipoxygenase, partialHomo sapiens (human)Potency39.810711
ATAD5 protein, partialHomo sapiens (human)Potency14.575011
Ataxin-2Homo sapiens (human)Potency14.125411
atrial natriuretic peptide receptor 1 precursorHomo sapiens (human)Potency37.933011
atrial natriuretic peptide receptor 2 precursorHomo sapiens (human)Potency16.481611
cellular tumor antigen p53 isoform aHomo sapiens (human)Potency12.589311
cytochrome P450 2D6Homo sapiens (human)Potency8.486611
cytochrome P450 2D6 isoform 1Homo sapiens (human)Potency13.971213
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency23.918511
D(1A) dopamine receptorHomo sapiens (human)Potency0.663222
D(1A) dopamine receptorSus scrofa (pig)Potency26.121611
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency35.481311
EWS/FLI fusion proteinHomo sapiens (human)Potency18.778644
Fumarate hydrataseHomo sapiens (human)Potency33.173411
gemininHomo sapiens (human)Potency13.335911
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency18.854114
Inositol monophosphatase 1Rattus norvegicus (Norway rat)Potency0.316211
Interferon betaHomo sapiens (human)Potency11.708613
muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)Potency0.071922
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency20.314811
polyproteinZika virusPotency33.173411
Polyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)Potency18.854112
PPM1D proteinHomo sapiens (human)Potency11.708612
serine/threonine-protein kinase mTOR isoform 1Homo sapiens (human)Potency21.301622
ThrombopoietinHomo sapiens (human)Potency15.848922
thyroid stimulating hormone receptorHomo sapiens (human)Potency7.943322
USP1 protein, partialHomo sapiens (human)Potency0.089111

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Bile salt export pumpHomo sapiens (human)IC50107.400011
Delta-type opioid receptorHomo sapiens (human)Ki0.003311
Delta-type opioid receptorRattus norvegicus (Norway rat)Ki0.003223
Kappa-type opioid receptorHomo sapiens (human)Ki0.043111
Kappa-type opioid receptorRattus norvegicus (Norway rat)Ki0.000212
Mu-type opioid receptorHomo sapiens (human)Ki0.000011
Mu-type opioid receptorRattus norvegicus (Norway rat)Ki0.000223
Voltage-dependent N-type calcium channel subunit alpha-1BHomo sapiens (human)IC5010.000011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Mu-type opioid receptorHomo sapiens (human)EC500.000011