A lipoxygenase inhibitor that interferes with the action of arachidonate 12-lipoxygenase (EC 1.13.11.31).
ChEBI ID: 64995
| Member | Definition | Class |
|---|---|---|
| 5,8,11-eicosatriynoic acid | A C20 polyunsaturated fatty acid having three triple bonds in the 5-, 8- and 11-positions. | 5,8,11-icosatriynoic acid |
| baicalein | A trihydroxyflavone with the hydroxy groups at positions C-5, -6 and -7. | baicalein |
| ML355 | A sulfonamide resulting from the formal condensation of the amino group of 2-aminobenzothiazole with the sulfo group of 4-[(2-hydroxy-3-methoxybenzyl)amino]benzenesulfonic acid. It is an inhibitor of 12-lipoxygenase, being developed by Veralox Therapeutics for the treatment of heparin-induced thrombocytopenia and thrombosis. | ML355 |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 29 (2.19) | 18.7374 |
| 1990's | 87 (6.58) | 18.2507 |
| 2000's | 297 (22.45) | 29.6817 |
| 2010's | 661 (49.96) | 24.3611 |
| 2020's | 249 (18.82) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 10 (0.73%) | 5.53% |
| Reviews | 56 (4.11%) | 6.00% |
| Case Studies | 1 (0.07%) | 4.05% |
| Observational | 1 (0.07%) | 0.25% |
| Other | 1,295 (95.01%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 13.0965 | 1 | 3 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 1.9953 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 13.1046 | 1 | 2 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 3.6854 | 2 | 2 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 5.2041 | 3 | 3 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 11.0792 | 1 | 2 |
| BRCA1 | Homo sapiens (human) | Potency | 10.8820 | 1 | 2 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 2.3060 | 2 | 2 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 6.8534 | 1 | 3 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 17.2493 | 1 | 4 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 25.1189 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 2.8294 | 2 | 3 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 9.3889 | 2 | 6 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 7.6336 | 1 | 3 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 2.8294 | 2 | 3 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 6.7412 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 23.9185 | 1 | 1 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 31.6228 | 2 | 2 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 8.4866 | 1 | 1 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | Potency | 0.6310 | 1 | 1 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 9.1318 | 2 | 2 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 44.5331 | 2 | 3 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 6.3455 | 1 | 4 |
| endonuclease IV | Escherichia coli | Potency | 7.9433 | 1 | 1 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 25.2686 | 4 | 4 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 26.6320 | 1 | 2 |
| G | Vesicular stomatitis virus | Potency | 6.7412 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 1.6360 | 1 | 1 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | Potency | 0.6310 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 0.6310 | 1 | 1 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | Potency | 0.6310 | 1 | 1 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | Potency | 0.6310 | 1 | 1 |
| hemoglobin subunit beta | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 6.1845 | 2 | 5 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 6.7412 | 1 | 1 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 35.4813 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 6.7412 | 1 | 2 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 15.6030 | 2 | 4 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 6.9241 | 1 | 2 |
| lethal(3)malignant brain tumor-like protein 1 isoform I | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 18.5252 | 2 | 6 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 22.1574 | 2 | 4 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 19.7020 | 1 | 2 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 10.0000 | 1 | 1 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 3.5481 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| PPM1D protein | Homo sapiens (human) | Potency | 18.5569 | 1 | 2 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 25.1633 | 2 | 7 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 44.6684 | 2 | 2 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 0.6310 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 10.0000 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 10.0000 | 1 | 1 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| WRN | Homo sapiens (human) | Potency | 5.3233 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 1-deoxy-D-xylulose 5-phosphate reductoisomerase | Escherichia coli K-12 | IC50 | 2.2000 | 1 | 1 |
| 4-aminobutyrate aminotransferase, mitochondrial | Homo sapiens (human) | IC50 | 12,800.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 7 | Homo sapiens (human) | IC50 | 350.0000 | 1 | 1 |
| Alpha-synuclein | Homo sapiens (human) | IC50 | 8.2000 | 1 | 1 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 41.0000 | 1 | 1 |
| Aurora kinase B | Homo sapiens (human) | IC50 | 4.0600 | 1 | 1 |
| Casein kinase II subunit alpha | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Casein kinase II subunit alpha 3 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Casein kinase II subunit alpha' | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Casein kinase II subunit beta | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Chain A, RNA-directed RNA polymerase NS5 | Dengue virus 2 16681-PDK53 | IC50 | 35.0600 | 1 | 1 |
| Cyclin-dependent kinase 1 | Homo sapiens (human) | IC50 | 6.5300 | 1 | 1 |
| Cytochrome P450 11B1, mitochondrial | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 1 | 1 |
| Cytochrome P450 1A1 | Homo sapiens (human) | Ki | 1.2200 | 1 | 1 |
| Cytochrome P450 1B1 | Homo sapiens (human) | Ki | 0.2600 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 29.0000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 9.2000 | 1 | 1 |
| Death-associated protein kinase 1 | Homo sapiens (human) | IC50 | 120.0000 | 1 | 1 |
| Dipeptidyl peptidase 4 | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| Fructose-1,6-bisphosphatase 1 | Homo sapiens (human) | IC50 | 29.0000 | 1 | 1 |
| G protein-coupled receptor kinase 6 | Homo sapiens (human) | IC50 | 8.7000 | 1 | 1 |
| G-protein coupled receptor 35 | Homo sapiens (human) | IC50 | 28.2000 | 1 | 1 |
| G2/mitotic-specific cyclin-B1 | Homo sapiens (human) | IC50 | 6.5300 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit theta | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Glucocorticoid receptor | Homo sapiens (human) | IC50 | 19.0000 | 1 | 1 |
| Integrase | Human immunodeficiency virus 1 | IC50 | 3.2960 | 5 | 5 |
| Lactoylglutathione lyase | Homo sapiens (human) | IC50 | 11.0000 | 1 | 1 |
| Linoleate 9S-lipoxygenase-4 | Glycine max (soybean) | IC50 | 22.0000 | 1 | 1 |
| Lysine-specific demethylase 4E | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| Lysine-specific demethylase 4E | Homo sapiens (human) | Ki | 4.3300 | 1 | 1 |
| Lysine-specific histone demethylase 1A | Homo sapiens (human) | IC50 | 12.5000 | 1 | 1 |
| Lysosomal alpha-glucosidase | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | IC50 | 66.9500 | 2 | 3 |
| Polyunsaturated fatty acid 5-lipoxygenase | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 2 | 2 |
| Polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | IC50 | 22.6229 | 4 | 7 |
| Polyunsaturated fatty acid lipoxygenase ALOX12 | Mus musculus (house mouse) | IC50 | 1.0000 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Ki | 0.8900 | 3 | 3 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Homo sapiens (human) | IC50 | 29.2667 | 3 | 6 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Homo sapiens (human) | Ki | 0.6000 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | IC50 | 57.2062 | 4 | 8 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Rattus norvegicus (Norway rat) | IC50 | 0.2600 | 1 | 1 |
| Progesterone receptor | Homo sapiens (human) | IC50 | 15.0000 | 1 | 1 |
| Prolyl endopeptidase | Homo sapiens (human) | IC50 | 36.0000 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | IC50 | 150.0000 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | IC50 | 150.0000 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 1 | 1 |
| Receptor-type tyrosine-protein kinase FLT3 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Receptor-type tyrosine-protein phosphatase S | Homo sapiens (human) | IC50 | 10.3000 | 1 | 1 |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 1.2200 | 9 | 10 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | IC50 | 0.9400 | 1 | 1 |
| Seed linoleate 13S-lipoxygenase-1 | Glycine max (soybean) | IC50 | 22.6000 | 1 | 1 |
| Serine/threonine-protein kinase PLK1 | Homo sapiens (human) | IC50 | 9.0000 | 1 | 1 |
| Serine/threonine-protein kinase PLK2 | Homo sapiens (human) | IC50 | 314.0000 | 1 | 1 |
| Serine/threonine-protein kinase PLK3 | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Sialidase-2 | Homo sapiens (human) | IC50 | 130.0000 | 1 | 1 |
| Sodium- and chloride-dependent betaine transporter | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 1 | 1 |
| Sodium- and chloride-dependent GABA transporter 1 | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 1 | 1 |
| Sodium- and chloride-dependent GABA transporter 2 | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 1 | 1 |
| Sodium- and chloride-dependent GABA transporter 3 | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 1 | 1 |
| Sucrase-isomaltase, intestinal | Homo sapiens (human) | IC50 | 43.5000 | 2 | 2 |
| Sucrase-isomaltase, intestinal | Rattus norvegicus (Norway rat) | IC50 | 156.0000 | 2 | 2 |
| Testosterone 17-beta-dehydrogenase 3 | Homo sapiens (human) | IC50 | 97.6100 | 2 | 2 |
| Trypsin-1 | Homo sapiens (human) | IC50 | 3.7000 | 1 | 1 |
| Trypsin-2 | Homo sapiens (human) | IC50 | 3.7000 | 1 | 1 |
| Trypsin-3 | Homo sapiens (human) | IC50 | 3.7000 | 1 | 1 |
| Tyrosine-protein kinase Yes | Homo sapiens (human) | IC50 | 3.3000 | 1 | 1 |
| UDP-glucuronosyltransferase 1A1 | Homo sapiens (human) | IC50 | 5.7000 | 2 | 2 |
| Urease subunit alpha | Helicobacter pylori 26695 | IC50 | 291.0000 | 1 | 1 |
| Urease subunit beta | Helicobacter pylori 26695 | IC50 | 291.0000 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Bos taurus (cattle) | IC50 | 37.4000 | 2 | 2 |
| Xanthine dehydrogenase/oxidase | Homo sapiens (human) | IC50 | 2.7900 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| G-protein coupled receptor 35 | Homo sapiens (human) | EC50 | 16.5000 | 2 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | EC50 | 2.3150 | 2 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | EC50 | 2.9400 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | Kd | 18.4000 | 3 | 3 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Androgen receptor | Homo sapiens (human) | EC150 | 18.9000 | 1 | 1 |
| Cyclic AMP-responsive element-binding protein 1 | Homo sapiens (human) | AC50 | 13.5000 | 1 | 1 |
| dual specificity tyrosine-phosphorylation-regulated kinase 1A | Rattus norvegicus (Norway rat) | AC50 | 14.5280 | 1 | 1 |
| Glucocorticoid receptor | Homo sapiens (human) | EC150 | 18.9000 | 1 | 1 |