Compounds > dendrophenol
Page last updated: 2024-11-08

dendrophenol

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Description

dendrophenol: isolated from Dendrobium loddigesii [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
Dendrobium loddigesiispecies[no description available]OrchidaceaeA plant family of the order Asparagales. All members of the orchid family have the same bilaterally symmetrical flower structure, with three sepals, but the flowers vary greatly in color and shape.[MeSH]

Cross-References

ID SourceID
PubMed CID176096
CHEMBL ID374047
SCHEMBL ID18563068
MeSH IDM0194935

Synonyms (18)

Synonym
dendrophenol
moscatilin
CHEMBL374047
aloifol ii
4-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-2,6-dimethoxyphenol
phenol, 4-(2-(4-hydroxy-3-methoxyphenyl)ethyl)-2,6-dimethoxy-
4,4'-dihydroxy-3,3',5-trimethoxybibenzyl
108853-14-1
phenol, 4-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-2,6-dimethoxy-
dibenzyl, 4,4'-dihydroxy-3,3',5-trimethoxy
YTRAYUIKLRABOQ-UHFFFAOYSA-N
DTXSID80148752
AKOS028108609
SCHEMBL18563068
CS-0032202
HY-N6031
MS-24394
EX-A6749

Research Excerpts

Toxicity

ExcerptReferenceRelevance
"Methylglyoxal (MGO) is an endogenous toxic compound that plays a vital role in diabetic complications such as diabetic neuropathy."( The protective effects of moscatilin against methylglyoxal-induced neurotoxicity via the regulation of p38/JNK MAPK pathways in PC12 neuron-like cells.
Lai, MC; Liou, SS; Liu, IM; Liu, WY, 2020)		0.56

Compound-Compound Interactions

ExcerptReferenceRelevance
" More importantly, LC-Orbitrap-MS/MS combined with diagnostic fragment ions and accurate mass measurements has been proved to be an effective method for the rapid identification of bibenzyl derivatives and their metabolites."( Identification and characterization of the metabolites of moscatilin in mouse, rat, dog, monkey and human hepatocytes by LC-Orbitrap-MS/MS combined with diagnostic fragment ions and accurate mass measurements.
Hu, A; Liu, Q; Ouyang, J, 2023)		0.91
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (88)

Assay IDTitleYearJournalArticle
AID1539111Cytotoxicity against mouse Neuro2a cells assessed as reduction in cell viability after 12 hrs by MTT assay
AID1539142Anti-alzhemeric activity in scopolamine-induced ICR mouse assessed as inhibition of tau phosphorylation at S202/T205 residues in brain at 25 to 100 mg/kg, ip for 2 weeks followed by scopolamine treatment by Western blot analysis
AID1539113Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability after 12 hrs by MTT assay
AID1824729Inhibition of pyruvate carboxylase in human HCCLM3 cells measured upto 24 hrs by PC assay kit2022Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1
Identification of Pyruvate Carboxylase as the Cellular Target of Natural Bibenzyls with Potent Anticancer Activity against Hepatocellular Carcinoma via Metabolic Reprogramming.
AID1539121Inhibition of GSK-3beta in mouse Neuro2a cells harboring with pCAX/FLAG-tagged APP and pRK5/EGFP-tagged Tau P301L mutant at 0.1 to 10 uM assessed as increase in GSK-3beta phosphorylation at Ser9 residues after 24 hrs by Western blot analysis
AID399546Spasmolytic activity in guinea pig ileum assessed as inhibition of spontaneous contraction relative to papaverine2004Journal of natural products, Feb, Volume: 67, Issue:2
Spasmolytic effects, mode of action, and structure-activity relationships of stilbenoids from Nidema boothii.
AID1539137Effect on cell cycle arrest in OA-induced human SH-SY5Y cells assessed as accumulation at sub-G1 phase at 0.1 uM pretreated for 6 hrs followed by OA addition and measured after 16 hrs by Western blot analysis (Rvb = 32.28%)
AID274761Inhibition of LPS and TNF-alpha-activated NO production in murine RAW 264.7 cells2007Journal of natural products, Jan, Volume: 70, Issue:1
Bioactive bibenzyl derivatives and fluorenones from Dendrobium nobile.
AID1325475Effect on LPS-induced iNOS expression in mouse RAW264.7 cells at 10 uM after 18 hrs by Western blot method relative to LPS2016Bioorganic & medicinal chemistry letters, 11-15, Volume: 26, Issue:22
Dihydrostilbenes and diarylpropanes: Synthesis and in vitro pharmacological evaluation as potent nitric oxide production inhibition agents.
AID1325466Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production at 1 uM after 18 hrs by Griess assay relative to control2016Bioorganic & medicinal chemistry letters, 11-15, Volume: 26, Issue:22
Dihydrostilbenes and diarylpropanes: Synthesis and in vitro pharmacological evaluation as potent nitric oxide production inhibition agents.
AID337333Antiplatelet activity against washed rabbit platelet assessed as inhibition of platelet activating factor-induced platelet aggregation at 100 ug/ml preincubated for 3 mins by turbidimetric method1994Journal of natural products, Sep, Volume: 57, Issue:9
Antiplatelet aggregation principles of Dendrobium loddigesii.
AID1824689Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay2022Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1
Identification of Pyruvate Carboxylase as the Cellular Target of Natural Bibenzyls with Potent Anticancer Activity against Hepatocellular Carcinoma via Metabolic Reprogramming.
AID1325472Cytotoxicity against mouse RAW264.7 cells assessed as cell proliferation rate at 50 uM after 24 hrs by MTS assay relative to control2016Bioorganic & medicinal chemistry letters, 11-15, Volume: 26, Issue:22
Dihydrostilbenes and diarylpropanes: Synthesis and in vitro pharmacological evaluation as potent nitric oxide production inhibition agents.
AID1539109Inhibition of GSK-3beta in mouse Neuro2a cells harboring with pCAX/FLAG-tagged APP and pRK5/EGFP-tagged Tau P301L mutant at 0.1 to 10 uM assessed as reduction in GSK-3beta phosphorylation at Tyr216 residues after 24 hrs by Western blot analysis
AID1539135Inhibition of p38 phosphorylation in OA-induced human SH-SY5Y cells pretreated for 24 hrs followed by OA addition and measured after 6 hrs by Western blot analysis
AID1593997Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay2019Bioorganic & medicinal chemistry, 06-15, Volume: 27, Issue:12
Design, synthesis and antitumour and anti-angiogenesis evaluation of 22 moscatilin derivatives.
AID337585Antiplatelet activity against washed rabbit platelet assessed as inhibition of arachidonic acid-induced platelet aggregation preincubated for 3 mins by turbidimetric method1994Journal of natural products, Sep, Volume: 57, Issue:9
Antiplatelet aggregation principles of Dendrobium loddigesii.
AID1539143Anti-alzhemeric activity in scopolamine-induced ICR mouse assessed as inhibition of tau phosphorylation at Ser262 residues in brain at 25 to 100 mg/kg, ip for 2 weeks followed by scopolamine treatment by Western blot analysis
AID1539136Inhibition of tau aggregation in OA-induced human SH-SY5Y cells at 0.1 to 5 uM pretreated for 24 hrs followed by OA addition and measured after 6 hrs by Western blot analysis
AID1593999Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay2019Bioorganic & medicinal chemistry, 06-15, Volume: 27, Issue:12
Design, synthesis and antitumour and anti-angiogenesis evaluation of 22 moscatilin derivatives.
AID1539122Inhibition of GSK3beta in mouse Neuro2a cells assessed as reduction in tau phosphorylation at S202/T205 residues at 0.1 to 5 uM pretreated for 12 to 24 hrs followed by OA addition and measured after 6 hrs by Western blot analysis
AID1539125Inhibition of GSK3beta in human SH-SY5Y cells assessed as reduction in tau phosphorylation at S262 residues at 0.1 to 5 uM pretreated for 12 to 24 hrs followed by OA addition and measured after 6 hrs by Western blot analysis
AID1594001Antiproliferative activity against human HCT116 cells incubated for 72 hrs by MTT assay2019Bioorganic & medicinal chemistry, 06-15, Volume: 27, Issue:12
Design, synthesis and antitumour and anti-angiogenesis evaluation of 22 moscatilin derivatives.
AID1539119Effect on total tau protein level in mouse Neuro2a cells harboring with pCAX/FLAG-tagged APP and pRK5/EGFP-tagged Tau P301L mutant at 0.1 to 10 uM after 12 to 24 hrs by Western blot analysis
AID1539127Effect on total tau protein level in human SH-SY5Y cells at 0.1 to 5 uM pretreated for 12 to 24 hrs followed by OA addition and measured after 6 hrs by Western blot analysis
AID1539130Inhibition of GSK-3beta in human SH-SY5Y cells assessed as increase in GSK-3beta phosphorylation at Ser9 residues at 0.1 to 5 uM pretreated for 24 hrs followed by OA addition and measured after 6 hrs by Western blot analysis
AID274759Antioxidant activity assessed by DPPH radical scavenging assay2007Journal of natural products, Jan, Volume: 70, Issue:1
Bioactive bibenzyl derivatives and fluorenones from Dendrobium nobile.
AID1539118Inhibition of GSK-3beta in human SH-SY5Y cells harboring with pCAX/FLAG-tagged APP and pRK5/EGFP-tagged Tau P301L mutant assessed as reduction in tau phosphorylation at S404 residues after 12 to 24 hrs by Western blot analysis
AID1539141Reversal of scopolamine-induced spatial memory impairment in ICR mouse assessed as decrease in time spent on closed arms at 25 to 100 mg/kg, ip for 2 weeks followed by scopolamine treatment and measured after 90 mins by Morris water maze test
AID337337Antiplatelet activity against washed rabbit platelet assessed as inhibition of arachidonic acid-induced platelet aggregation at 20 ug/ml preincubated for 3 mins by turbidimetric method1994Journal of natural products, Sep, Volume: 57, Issue:9
Antiplatelet aggregation principles of Dendrobium loddigesii.
AID337335Antiplatelet activity against washed rabbit platelet assessed as inhibition of collagen-induced platelet aggregation at 50 ug/ml preincubated for 3 mins by turbidimetric method1994Journal of natural products, Sep, Volume: 57, Issue:9
Antiplatelet aggregation principles of Dendrobium loddigesii.
AID337332Antiplatelet activity against washed rabbit platelet assessed as inhibition of collagen-induced platelet aggregation at 100 ug/ml preincubated for 3 mins by turbidimetric method1994Journal of natural products, Sep, Volume: 57, Issue:9
Antiplatelet aggregation principles of Dendrobium loddigesii.
AID1539116Inhibition of GSK-3beta in mouse Neuro2a cells harboring with pCAX/FLAG-tagged APP and pRK5/EGFP-tagged Tau P301L mutant assessed as reduction in tau phosphorylation at S404 residues after 12 to 24 hrs by Western blot analysis
AID1169331Cytotoxicity against human MCF7 cells assessed as reduction in cell number2014Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
Cytotoxic bibenzyl dimers from the stems of Dendrobium fimbriatum Hook.
AID1539129Inhibition of GSK-3beta in human SH-SY5Y cells harboring with pCAX/FLAG-tagged APP and pRK5/EGFP-tagged Tau P301L mutant at 0.1 to 10 uM assessed as increase in GSK-3beta phosphorylation at Ser9 residues after 24 hrs by Western blot analysis
AID1539140Anti-alzhemeric activity in scopolamine-induced ICR mouse assessed as increase in swimming speed at 25 to 100 mg/kg, ip for 2 weeks followed by scopolamine treatment and measured after 90 mins by Morris water maze test
AID1539123Inhibition of GSK3beta in mouse Neuro2a cells assessed as reduction in tau phosphorylation at S262 residues at 0.1 to 5 uM pretreated for 12 to 24 hrs followed by OA addition and measured after 6 hrs by Western blot analysis
AID1325469Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production at 50 to 100 uM after 18 hrs by Griess assay relative to control2016Bioorganic & medicinal chemistry letters, 11-15, Volume: 26, Issue:22
Dihydrostilbenes and diarylpropanes: Synthesis and in vitro pharmacological evaluation as potent nitric oxide production inhibition agents.
AID274760Antioxidant activity assessed by ORAC assay2007Journal of natural products, Jan, Volume: 70, Issue:1
Bioactive bibenzyl derivatives and fluorenones from Dendrobium nobile.
AID337341Antiplatelet activity against washed rabbit platelet assessed as inhibition of arachidonic acid-induced platelet aggregation at 5 ug/ml preincubated for 3 mins by turbidimetric method1994Journal of natural products, Sep, Volume: 57, Issue:9
Antiplatelet aggregation principles of Dendrobium loddigesii.
AID1539124Inhibition of GSK3beta in human SH-SY5Y cells assessed as reduction in tau phosphorylation at S202/T205 residues at 0.1 to 5 uM pretreated for 12 to 24 hrs followed by OA addition and measured after 6 hrs by Western blot analysis
AID1539115Inhibition of GSK-3beta in mouse Neuro2a cells harboring with pCAX/FLAG-tagged APP and pRK5/EGFP-tagged Tau P301L mutant assessed as reduction in tau phosphorylation at S396 residues after 12 to 24 hrs by Western blot analysis
AID1325467Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production at 10 uM after 18 hrs by Griess assay relative to control2016Bioorganic & medicinal chemistry letters, 11-15, Volume: 26, Issue:22
Dihydrostilbenes and diarylpropanes: Synthesis and in vitro pharmacological evaluation as potent nitric oxide production inhibition agents.
AID381193Antioxidant activity against copper-induced lipid peroxidation in human LDL after 1 hr relative to probucol1999Journal of natural products, Sep, Volume: 62, Issue:9
Antioxidant principles from Ephemerantha lonchophylla.
AID1539112Cytotoxicity against mouse Neuro2a cells assessed as reduction in cell viability after 24 hrs by MTT assay
AID1325474Cytotoxicity against mouse RAW264.7 cells assessed as decrease in cell proliferation rate after 24 hrs by MTS assay2016Bioorganic & medicinal chemistry letters, 11-15, Volume: 26, Issue:22
Dihydrostilbenes and diarylpropanes: Synthesis and in vitro pharmacological evaluation as potent nitric oxide production inhibition agents.
AID1824731Inhibition of pyruvate carboxylase in human HCCLM3 cell lysate measured upto 24 hrs by PC assay kit2022Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1
Identification of Pyruvate Carboxylase as the Cellular Target of Natural Bibenzyls with Potent Anticancer Activity against Hepatocellular Carcinoma via Metabolic Reprogramming.
AID1169332Cytotoxicity against human SW480 cells assessed as reduction in cell number2014Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
Cytotoxic bibenzyl dimers from the stems of Dendrobium fimbriatum Hook.
AID1539114Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability after 24 hrs by MTT assay
AID337340Antiplatelet activity against washed rabbit platelet assessed as inhibition of collagen-induced platelet aggregation at 10 ug/ml preincubated for 3 mins by turbidimetric method1994Journal of natural products, Sep, Volume: 57, Issue:9
Antiplatelet aggregation principles of Dendrobium loddigesii.
AID337339Antiplatelet activity against washed rabbit platelet assessed as inhibition of arachidonic acid-induced platelet aggregation at 10 ug/ml preincubated for 3 mins by turbidimetric method1994Journal of natural products, Sep, Volume: 57, Issue:9
Antiplatelet aggregation principles of Dendrobium loddigesii.
AID1539139Anti-alzhemeric activity in scopolamine-induced ICR mouse assessed as increase in time spent in the target quadrant at 25 to 100 mg/kg, ip for 2 weeks followed by scopolamine treatment and measured after 90 mins by Morris water maze test
AID1539132Antioxidant activity in OA-induced human SH-SY5Y cells assessed as decrease in GSH level at 0.1 to 1 uM pretreated for 12 hrs followed by OA addition and measured after 12 hrs
AID484514Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production2010Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12
Phenanthrenes from Dendrobium nobile and their inhibition of the LPS-induced production of nitric oxide in macrophage RAW 264.7 cells.
AID1325468Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production at 1 to 10 uM after 18 hrs by Griess assay2016Bioorganic & medicinal chemistry letters, 11-15, Volume: 26, Issue:22
Dihydrostilbenes and diarylpropanes: Synthesis and in vitro pharmacological evaluation as potent nitric oxide production inhibition agents.
AID1539128Inhibition of GSK-3beta in human SH-SY5Y cells harboring with pCAX/FLAG-tagged APP and pRK5/EGFP-tagged Tau P301L mutant at 0.1 to 10 uM assessed as reduction in GSK-3beta phosphorylation at Tyr216 residues after 24 hrs by Western blot analysis
AID337334Antiplatelet activity against washed rabbit platelet assessed as inhibition of arachidonic acid-induced platelet aggregation at 50 ug/ml preincubated for 3 mins by turbidimetric method1994Journal of natural products, Sep, Volume: 57, Issue:9
Antiplatelet aggregation principles of Dendrobium loddigesii.
AID1325473Cytotoxicity against mouse RAW264.7 cells assessed as cell proliferation rate at 100 uM after 24 hrs by MTS assay relative to control2016Bioorganic & medicinal chemistry letters, 11-15, Volume: 26, Issue:22
Dihydrostilbenes and diarylpropanes: Synthesis and in vitro pharmacological evaluation as potent nitric oxide production inhibition agents.
AID1539133Inhibition of JNK phosphorylation in OA-induced human SH-SY5Y cells pretreated for 24 hrs followed by OA addition and measured after 6 hrs by Western blot analysis
AID1169329Cytotoxicity against human SMMC7721 cells assessed as reduction in cell number2014Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
Cytotoxic bibenzyl dimers from the stems of Dendrobium fimbriatum Hook.
AID1539138Anti-alzhemeric activity in scopolamine-induced ICR mouse assessed as increase in swimming distance at 25 to 100 mg/kg, ip for 2 weeks followed by scopolamine treatment and measured after 90 mins by Morris water maze test
AID1169328Cytotoxicity against human HL60 cells assessed as reduction in cell number2014Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
Cytotoxic bibenzyl dimers from the stems of Dendrobium fimbriatum Hook.
AID1539145Anti-alzhemeric activity in scopolamine-induced ICR mouse assessed as increase in GSK-3beta phosphorylation Ser9 residues in brain at 25 to 100 mg/kg, ip for 2 weeks followed by scopolamine treatment by Western blot analysis
AID1539120Effect on total tau protein level in human SH-SY5Y cells harboring with pCAX/FLAG-tagged APP and pRK5/EGFP-tagged Tau P301L mutant at 0.1 to 10 uM after 12 to 24 hrs by Western blot analysis
AID1325471Cytotoxicity against mouse RAW264.7 cells assessed as cell proliferation rate at 10 uM after 24 hrs by MTS assay relative to control2016Bioorganic & medicinal chemistry letters, 11-15, Volume: 26, Issue:22
Dihydrostilbenes and diarylpropanes: Synthesis and in vitro pharmacological evaluation as potent nitric oxide production inhibition agents.
AID337338Antiplatelet activity against washed rabbit platelet assessed as inhibition of collagen-induced platelet aggregation at 20 ug/ml preincubated for 3 mins by turbidimetric method1994Journal of natural products, Sep, Volume: 57, Issue:9
Antiplatelet aggregation principles of Dendrobium loddigesii.
AID1539148Toxicity in ICR mouse assessed as effect on body weight at 25 to 100 mg/kg, ip for 2 weeks
AID1325470Cytotoxicity against mouse RAW264.7 cells assessed as cell proliferation rate at 1 uM after 24 hrs by MTS assay relative to control2016Bioorganic & medicinal chemistry letters, 11-15, Volume: 26, Issue:22
Dihydrostilbenes and diarylpropanes: Synthesis and in vitro pharmacological evaluation as potent nitric oxide production inhibition agents.
AID1539117Inhibition of GSK-3beta in human SH-SY5Y cells harboring with pCAX/FLAG-tagged APP and pRK5/EGFP-tagged Tau P301L mutant assessed as reduction in tau phosphorylation at S396 residues after 12 to 24 hrs by Western blot analysis
AID1824692Antiproliferative activity against human HCCLM3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay2022Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1
Identification of Pyruvate Carboxylase as the Cellular Target of Natural Bibenzyls with Potent Anticancer Activity against Hepatocellular Carcinoma via Metabolic Reprogramming.
AID337330Antiplatelet activity against washed rabbit platelet assessed as inhibition of arachidonic acid-induced platelet aggregation at 100 ug/ml preincubated for 3 mins by turbidimetric method1994Journal of natural products, Sep, Volume: 57, Issue:9
Antiplatelet aggregation principles of Dendrobium loddigesii.
AID337336Antiplatelet activity against washed rabbit platelet assessed as inhibition of platelet activating factor-induced platelet aggregation at 50 ug/ml preincubated for 3 mins by turbidimetric method1994Journal of natural products, Sep, Volume: 57, Issue:9
Antiplatelet aggregation principles of Dendrobium loddigesii.
AID1169330Cytotoxicity against human A549 cells assessed as reduction in cell number2014Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
Cytotoxic bibenzyl dimers from the stems of Dendrobium fimbriatum Hook.
AID1594000Antiproliferative activity against human MKN45 cells incubated for 72 hrs by MTT assay2019Bioorganic & medicinal chemistry, 06-15, Volume: 27, Issue:12
Design, synthesis and antitumour and anti-angiogenesis evaluation of 22 moscatilin derivatives.
AID1539134Inhibition of ERK phosphorylation in OA-induced human SH-SY5Y cells pretreated for 24 hrs followed by OA addition and measured after 6 hrs by Western blot analysis
AID337583Antiplatelet activity against washed rabbit platelet assessed as inhibition of collagen-induced platelet aggregation at 5 ug/ml preincubated for 3 mins by turbidimetric method1994Journal of natural products, Sep, Volume: 57, Issue:9
Antiplatelet aggregation principles of Dendrobium loddigesii.
AID1539147Anti-alzhemeric activity in scopolamine-induced ICR mouse assessed as increase in GSK-3beta phosphorylation Ser9 residues in hippocampal CA1 region at 25 to 100 mg/kg, ip for 2 weeks followed by scopolamine treatment by immunohistochemistry-based analysis
AID1539110Inhibition of GSK-3beta in human SH-SY5Y cells assessed as reduction in GSK-3beta phosphorylation at Tyr216 residues at 0.1 to 5 uM pretreated for 24 hrs followed by OA addition and measured after 6 hrs by Western blot analysis
AID1539144Anti-alzhemeric activity in scopolamine-induced ICR mouse assessed as inhibition of tau phosphorylation at Ser396 residues in brain at 25 to 100 mg/kg, ip for 2 weeks followed by scopolamine treatment by Western blot analysis
AID337331Antiplatelet activity against washed rabbit platelet assessed as inhibition of thrombin-induced platelet aggregation at 100 ug/ml preincubated for 3 mins by turbidimetric method1994Journal of natural products, Sep, Volume: 57, Issue:9
Antiplatelet aggregation principles of Dendrobium loddigesii.
AID1539126Effect on total tau protein level in mouse Neuro2a cells at 0.1 to 5 uM pretreated for 12 to 24 hrs followed by OA addition and measured after 6 hrs by Western blot analysis
AID399545Spasmolytic activity in guinea pig ileum assessed as inhibition of spontaneous contraction2004Journal of natural products, Feb, Volume: 67, Issue:2
Spasmolytic effects, mode of action, and structure-activity relationships of stilbenoids from Nidema boothii.
AID1539131Antioxidant activity in OA-induced human SH-SY5Y cells assessed as increase in MDA level at 0.1 to 1 uM pretreated for 12 hrs followed by OA addition and measured after 12 hrs
AID1539146Anti-alzhemeric activity in scopolamine-induced ICR mouse assessed as reduction in tau phosphorylation at S202/T205 residues in hippocampal CA1 region at 25 to 100 mg/kg, ip for 2 weeks followed by scopolamine treatment by immunohistochemistry-based analy
AID1539149Toxicity in ICR mouse assessed as effect on body weight at 1 mg/kg, ip for 2 weeks
AID1593998Antiproliferative activity against human HepG2 cells incubated for 72 hrs by MTT assay2019Bioorganic & medicinal chemistry, 06-15, Volume: 27, Issue:12
Design, synthesis and antitumour and anti-angiogenesis evaluation of 22 moscatilin derivatives.
AID337584Antiplatelet activity against washed rabbit platelet assessed as inhibition of collagen-induced platelet aggregation at 2 ug/ml preincubated for 3 mins by turbidimetric method1994Journal of natural products, Sep, Volume: 57, Issue:9
Antiplatelet aggregation principles of Dendrobium loddigesii.
AID1594019Anti-angiogenic activity in zebrafish-guided angiogenesis model assessed as reduction in inter-segmental blood vessels measured at 72 hpf by fluorescence microscopy2019Bioorganic & medicinal chemistry, 06-15, Volume: 27, Issue:12
Design, synthesis and antitumour and anti-angiogenesis evaluation of 22 moscatilin derivatives.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (37)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's4 (10.81)18.2507
2000's5 (13.51)29.6817
2010's19 (51.35)24.3611
2020's9 (24.32)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.30

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.30 (24.57)
Research Supply Index3.64 (2.92)
Research Growth Index4.94 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.30)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (2.70%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other36 (97.30%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
guaiacol
Guaiacol: An agent thought to have disinfectant properties and used as an expectorant. (From Martindale, The Extra Pharmacopoeia, 30th ed, p747). methylcatechol : Any member of the class of catechols carrying one or more methyl substituents.. guaiacol : A monomethoxybenzene that consists of phenol with a methoxy substituent at the ortho position.		2.7530guaiacolsdisinfectant;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
expectorant;
plant metabolite
pyruvaldehyde
Pyruvaldehyde: An organic compound used often as a reagent in organic synthesis, as a flavoring agent, and in tanning. It has been demonstrated as an intermediate in the metabolism of acetone and its derivatives in isolated cell preparations, in various culture media, and in vivo in certain animals.. methylglyoxal : A 2-oxo aldehyde derived from propanal.		2.25102-oxo aldehyde;
propanals		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
oxaloacetic acid
Oxaloacetic Acid: A dicarboxylic acid ketone that is an important metabolic intermediate of the CITRIC ACID CYCLE. It can be converted to ASPARTIC ACID by ASPARTATE TRANSAMINASE.. oxaloacetic acid : An oxodicarboxylic acid that is succinic acid bearing a single oxo group.		2.4110C4-dicarboxylic acid;
oxo dicarboxylic acid		geroprotector;
metabolite
phenol
[no description available]		2.2510phenolsantiseptic drug;
disinfectant;
human xenobiotic metabolite;
mouse metabolite
pimagedine
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure. aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.		2.0510guanidines;
one-carbon compound		EC 1.14.13.39 (nitric oxide synthase) inhibitor;
EC 1.4.3.4 (monoamine oxidase) inhibitor
chlorpromazine
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.. chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.		2.0210organochlorine compound;
phenothiazines;
tertiary amine		anticoronaviral agent;
antiemetic;
dopaminergic antagonist;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
phenothiazine antipsychotic drug
papaverine
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.. papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.		2.0210benzylisoquinoline alkaloid;
dimethoxybenzene;
isoquinolines		antispasmodic drug;
vasodilator agent
probucol
Probucol: A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).. probucol : A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high levels of cholesterol in blood.		210dithioketal;
polyphenol		anti-inflammatory drug;
anticholesteremic drug;
antilipemic drug;
antioxidant;
cardiovascular drug
aspartic acid
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.. aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent. L-aspartic acid : The L-enantiomer of aspartic acid.		2.4110aspartate family amino acid;
aspartic acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
mouse metabolite;
neurotransmitter
adenosine diphosphate
Adenosine Diphosphate: Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.		2.2510adenosine 5'-phosphate;
purine ribonucleoside 5'-diphosphate		fundamental metabolite;
human metabolite
2-methylpentane
Hexanes: Six-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives. Various polyneuropathies are caused by hexane poisoning.		210alkane
n-hexane
hexane : An unbranched alkane containing six carbon atoms.		210alkane;
volatile organic compound		neurotoxin;
non-polar solvent
scoparone
scoparone: structure. scoparone : A member of the class of coumarins that is esculetin in which the two hydroxy groups at positions 6 and 7 are replaced by methoxy groups. It is a major constituent of the Chinese herbal medicine Yin Chen Hao, and exhibits a variety of pharmacological activities such as anti-inflammatory, anti-allergic, and anti-tumor activities.		2.2510aromatic ether;
coumarins		anti-allergic agent;
anti-inflammatory agent;
antihypertensive agent;
antilipemic drug;
immunosuppressive agent;
plant metabolite
butylated hydroxytoluene
2,6-di-tert-butyl-4-methylphenol : A member of the class of phenols that is 4-methylphenol substituted by tert-butyl groups at positions 2 and 6.		2.0310phenolsantioxidant;
ferroptosis inhibitor;
food additive;
geroprotector
octyl gallate
[no description available]		2.4110gallate esterfood antioxidant;
hypoglycemic agent;
plant metabolite
triptolide
[no description available]		3.1510diterpenoid;
epoxide;
gamma-lactam;
organic heteroheptacyclic compound		antispermatogenic agent;
plant metabolite
celastrol
[no description available]		3.1510monocarboxylic acid;
pentacyclic triterpenoid		anti-inflammatory drug;
antineoplastic agent;
antioxidant;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
Hsp90 inhibitor;
metabolite
omega-n-methylarginine
omega-N-Methylarginine: A competitive inhibitor of nitric oxide synthetase.. N(omega)-methyl-L-arginine : A L-arginine derivative with a N(omega)-methyl substituent.		2.1310amino acid zwitterion;
arginine derivative;
guanidines;
L-arginine derivative;
non-proteinogenic L-alpha-amino acid
3,3',4,5'-tetrahydroxybibenzyl
3,3',4,5'-tetrahydroxybibenzyl: from Cassia garrettiana; structure given in first source		2.0210
cypripedin
cypripedin: sensitizing agent for contact dermatitis from Lady Slipper (Cypripedium calceolus); structure		2.2510phenanthrol
sb 203580
[no description available]		2.1110imidazoles;
monofluorobenzenes;
pyridines;
sulfoxide		EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
geroprotector;
Hsp90 inhibitor;
neuroprotective agent
dihydroresveratrol
dihydroresveratrol: structure in first source. dihydroresveratrol : A stilbenol that is 1,1'-ethane-1,2-diyldibenzene with hydroxy groups at positions 1, 3 and 4'.		2.0210stilbenolplant metabolite;
xenobiotic metabolite
erianin
Erianin: from Dendrobium chrysotoxum; structure in first source		2.7220
naringenin
(S)-naringenin : The (S)-enantiomer of naringenin.		2.2510(2S)-flavan-4-one;
naringenin		expectorant;
plant metabolite
dihydropinosylvin
dihydropinosylvin : A member of the class of resorcinols carrying an additional 2-phenylethyl substituent at position 5.		2.0210diphenylethane;
resorcinols		EC 1.14.18.1 (tyrosinase) inhibitor;
plant metabolite
lusianthridin
lusianthridin: from rhizome of Arundina graminifolia		2.4420dihydrophenanthrene
Hircinol
[no description available]		2.5320phenanthrenes
lignans
Lignans: A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)		2.1710
arachidonic acid
icosa-5,8,11,14-tetraenoic acid : Any icosatetraenoic acid with the double bonds at positions 5, 8, 11 and 14.. arachidonate : A long-chain fatty acid anion resulting from the removal of a proton from the carboxy group of arachidonic acid.		1.9810icosa-5,8,11,14-tetraenoic acid;
long-chain fatty acid;
omega-6 fatty acid		Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
human metabolite;
mouse metabolite
resveratrol
trans-resveratrol : A resveratrol in which the double bond has E configuration.		2.4220resveratrolantioxidant;
phytoalexin;
plant metabolite;
quorum sensing inhibitor;
radical scavenger
shikonin
shikonin: a naphthazarin; has antineoplastic and angiogenesis inhibiting activities		3.1510hydroxy-1,4-naphthoquinone
rhapontin
rhapontin: constituent of rhubarb rhizome		2.4110rhaponticinangiogenesis inhibitor;
anti-allergic agent;
anti-inflammatory agent;
antilipemic drug;
antineoplastic agent;
apoptosis inducer;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
hypoglycemic agent;
neuroprotective agent;
plant metabolite
curcumin
Curcumin: A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.. curcumin : A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.		3.1510aromatic ether;
beta-diketone;
diarylheptanoid;
enone;
polyphenol		anti-inflammatory agent;
antifungal agent;
antineoplastic agent;
biological pigment;
contraceptive drug;
dye;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor;
EC 1.8.1.9 (thioredoxin reductase) inhibitor;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
flavouring agent;
food colouring;
geroprotector;
hepatoprotective agent;
immunomodulator;
iron chelator;
ligand;
lipoxygenase inhibitor;
metabolite;
neuroprotective agent;
nutraceutical;
radical scavenger
gigantol
gigantol: structure in first source		3.1750
naphthoquinones
Naphthoquinones: Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.		3.6120
chrysotoxine
chrysotoxine: inhibits 6-hydroxydopamine induced apoptosis in SH-SY5Y cells via mitochondria protection and NF-κB modulation; structure in first source		2.4920
semaxinib
semaxanib : An oxindole that is 3-methyleneoxindole in which one of the hydrogens of the methylene group is replaced by a 3,5-dimethylpyrrol-2-yl group.		2.2110olefinic compound;
oxindoles;
pyrroles		angiogenesis modulating agent;
antineoplastic agent;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor;
vascular endothelial growth factor receptor antagonist
bakuchiol
bakuchiol: chief component of Psoralea corylifolia Linn; structure		3.1510
gambogic acid
gambogic acid: RN given refers to (1R-(1alpha,1(Z),3abeta,5alpha,11beta,14aS*))-isomer		2.2110pyranoxanthonesmetabolite
erianthridin
erianthridin: isolated from an extract of the orchid Maxillaria densa; structure in first source		2.0510
denbinobin
denbinobin: antineoplastic from Dendrobium moniliforme (Orchidaceae); structure in first source		210
3,7-dihydroxy-2,4-dimethoxyphenanthrene
3,7-dihydroxy-2,4-dimethoxyphenanthrene: from the orchid Scaphyglottis livida; structure in first source		2.0510
batatasin-iii
[no description available]		2.4520stilbenoid
cyclic diadenosine phosphate
cyclic di-AMP : A cyclic purine dinucleotide that is the 3',5'-cyclic dimer of AMP.		2.4110adenyl ribonucleotide;
cyclic purine dinucleotide		Mycoplasma genitalium metabolite
balanophonin
balanophonin: from fruit wall of Cirsium vulgare; structure in first source		2.1710
ascorbic acid
Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.		2.0310ascorbic acid;
vitamin C		coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent
warfarin
Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.		2.2510benzenes;
hydroxycoumarin;
methyl ketone
phenanthrenes
Phenanthrenes: POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.. phenanthrenes : Any benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof.		3.8330
ConditionIndicatedRelationship StrengthStudiesTrials
Muscle Contraction
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.		02.0210
Hepatocellular Carcinoma
[description not available]		02.4110
Cancer of Liver
[description not available]		02.4820
Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.		02.4110
Liver Neoplasms
Tumors or cancer of the LIVER.		02.4820
Carcinoma, Squamous Cell of Head and Neck
[description not available]		02.2510
Squamous Cell Carcinoma of Head and Neck
The most common type of head and neck carcinoma that originates from cells on the surface of the NASAL CAVITY; MOUTH; PARANASAL SINUSES, SALIVARY GLANDS, and LARYNX. Mutations in TNFRSF10B, PTEN, and ING1 genes are associated with this cancer.		02.2510
Malignant Melanoma
[description not available]		02.2510
Melanoma
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)		02.2510
Degenerative Diseases, Central Nervous System
[description not available]		02.2510
Neurodegenerative Diseases
Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.		02.2510
Angiogenesis, Pathologic
[description not available]		02.5220
Cancer of Ovary
[description not available]		02.5320
Ovarian Neoplasms
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.		02.5320
Retinal Diseases
Diseases involving the RETINA.		02.1710
Cancer of Lung
[description not available]		02.7530
Invasiveness, Neoplasm
[description not available]		02.0810
Lung Neoplasms
Tumors or cancer of the LUNG.		02.7530
Esophageal Squamous Cell Carcinoma
A carcinoma that originates usually from cells on the surface of the middle and lower third of the ESOPHAGUS. Tumor cells exhibit typical squamous morphology and form large polypoid lesions. Mutations in RNF6, LZTS1, TGFBR2, DEC1, and WWOX1 genes are associated with this cancer.		02.0810
Carcinoma, Epidermoid
[description not available]		02.0810
Cancer of Esophagus
[description not available]		02.0810
Carcinoma, Squamous Cell
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)		02.0810
Esophageal Neoplasms
Tumors or cancer of the ESOPHAGUS.		02.0810
Carcinoma, Anaplastic
[description not available]		02.1110
Carcinoma
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.		02.1110
Metastase
[description not available]		02.5120
Neoplasm Metastasis
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.		02.5120
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.1510
Cancer of Pancreas
[description not available]		02.1510
Pancreatic Neoplasms
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).		02.1510
Colorectal Cancer
[description not available]		02.0410
Colorectal Neoplasms
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.		02.0410
Benign Neoplasms
[description not available]		03.3820
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		03.3820
Breast Cancer
[description not available]		02.0810
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.0810
Cancer of Stomach
[description not available]		02.0110
Stomach Neoplasms
Tumors or cancer of the STOMACH.		02.0110