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cucurbitacin
Any one of a class of tetracyclic triterpenoids, formally derived from the triterpene hydrocarbon cucurbitane, developed by some plants (especially those of the family Cucurbitaceaeas) as a defence mechanism against herbivores.
ChEBI ID: 16219
Members (6)
| Member | Definition | Role |
|---|---|---|
| cucurbitacin b | A cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 5 and 23; a hydroxy function at C-25 is acetylated. | cucurbitacin B |
| cucurbitacin c | Cucurbitacin C | |
| cucurbitacin d | A cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 5 and 23. | cucurbitacin D |
| cucurbitacin i | A cucurbitacin that is 9,10,14-trimethyl-4,9-cyclo-9,10-secocholesta-2,5,23-triene substituted by hydroxy groups at positions 2, 16, 20 and 25 and oxo groups at positions 1, 11 and 22. | cucurbitacin I |
| cucurbitacin I 2-O-beta-D-glucopyranoside | A triterpenoid saponin that is cucurbitacin I attached to a beta-D-glucopyranosyl residue at position 2 via a glycosidic linkage. It has been isolated from Machilus yaoshansis. | cucurbitacin I 2-O-beta-D-glucopyranoside |
| nsc 106399 | A cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 1, 5 and 23. | cucurbitacin E |
Research
Studies (371)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 7 (1.89) | 18.7374 |
| 1990's | 9 (2.43) | 18.2507 |
| 2000's | 62 (16.71) | 29.6817 |
| 2010's | 222 (59.84) | 24.3611 |
| 2020's | 71 (19.14) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 2 (0.47%) | 5.53% |
| Reviews | 13 (3.07%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 409 (96.46%) | 84.16% |