acesulfame potassium profile

ID Source	ID
PubMed CID	11074431
CHEMBL ID	1351474
CHEBI ID	184415
MeSH ID	M0309536

Synonym
potassium 6-methyl-4-oxo-4h-1,2,3-oxathiazin-3-ide 2,2-dioxide
acesulfame-k
55589-62-3
NCGC00090729-01
acesulfame potassium salt
1,2,3-oxathiazin-4(3h)-one, 6-methyl-, 2,2-dioxide, potassium salt
potassium 6-methyl-1,2,3-oxathiazin-4(3h)-one 2,2-dioxide
acesulfame k, analytical standard
NCGC00090729-02
acesulfame k
6-methyl-1,2,3-oxathiazin-4(3h)-one 2,2-dioxide potassium salt
D08836
acesulfame potassium (nf)
potassium;6-methyl-2,2-dioxo-1-oxa-2lambda6-thia-3-azanidacyclohex-5-en-4-one
CHEBI:184415
HMS3264B22
NCGC00257361-01
cas-55589-62-3
tox21_303370
dtxsid1030606 ,
dtxcid9010606
NCGC00259972-01
tox21_202423
nsc-760104
tox21_111001
ins no.950
e 950
potassium acesulfamate
e-950
sunett d
otizon
e950
CHEMBL1351474
ins-950
AKOS016015051
FT-0621718
AKOS025310719
CCG-213614
smr001595518
MLS006010910
h-d-trp-oethcl
acesulfame potassium, european pharmacopoeia (ep) reference standard
mfcd00043833
acesulfame potassium, united states pharmacopeia (usp) reference standard
acesulfame k, for food analysis, >=99.0%
acesulfame k, pharmaceutical secondary standard; certified reference material
CS-0010111
acesulfame (potassium)
HY-D0195
acesulfame potassium 1000 microg/ml in acetonitrile
AS-12294
acesulfamepotassium
761 - sweeteners
517 - dilutable/ready to drink
516 - carbonated drink (degassed)

Excerpt	Reference	Relevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."	( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)	0.51

Occurs in Manufacturing (318 Items)

Item	Process	Frequency
Beverages	core-ingredient	2,130
Sodas	core-ingredient	614
Carbonated drinks	core-ingredient	612
Dried products to be rehydrated	core-ingredient	484
Dried products	core-ingredient	484
Dehydrated beverages	core-ingredient	483
Waters	core-ingredient	446
Desserts	core-ingredient	409
Dairies	core-ingredient	350
Yogurts	core-ingredient	321
Fermented dairy desserts	core-ingredient	321
Dairy desserts	core-ingredient	321
Fermented milk products	core-ingredient	321
Fermented foods	core-ingredient	321
Plant-based foods and beverages	core-ingredient	281
Plant-based beverages	core-ingredient	181
Iced teas	core-ingredient	174
Tea-based beverages	core-ingredient	173
Artificially sweetened beverages	core-ingredient	168
Snacks	core-ingredient	126
Diet beverages	core-ingredient	108
Sweet snacks	core-ingredient	97
Sweeteners	core-ingredient	92
Diet sodas	core-ingredient	90
Sweetened beverages	core-ingredient	88
Confectioneries	core-ingredient	87
Plant-based foods	core-ingredient	83
Syrups	core-ingredient	82
Simple syrups	core-ingredient	75
Colas	core-ingredient	72
Energy drinks	core-ingredient	62
Diet cola soft drink	core-ingredient	61
Frozen desserts	core-ingredient	58
Frozen foods	core-ingredient	58
Dietary supplements	core-ingredient	56
Fruits based foods	core-ingredient	49
Fruits and vegetables based foods	core-ingredient	49
Bodybuilding supplements	core-ingredient	46
Canned fruits	core-ingredient	44
Canned plant-based foods	core-ingredient	44
Canned foods	core-ingredient	44
Energy drink without sugar and with artificial sweeteners	core-ingredient	39
Greek-style yogurts	core-ingredient	38
Beverages and beverages preparations	core-ingredient	36
Hot beverages	core-ingredient	30
Teas	core-ingredient	29
Fruit-based beverages	core-ingredient	26
Protein shakes	core-ingredient	26
Milks	core-ingredient	24
Open Products Facts	core-ingredient	23
Non food products	core-ingredient	23
Protein powders	core-ingredient	23
en:Beverages	core-ingredient	22
Dietary drink for sport	core-ingredient	21
Cereals and potatoes	core-ingredient	19
Cereals and their products	core-ingredient	17
Creamer	core-ingredient	17
Milk substitutes	core-ingredient	17
Dairy substitutes	core-ingredient	17
Lemon flavored iced teas	core-ingredient	17
Lemonade	core-ingredient	17
Sugars	core-ingredient	16
Vanilla yogurt	core-ingredient	15
Food additives	core-ingredient	14
Chewing gum	core-ingredient	12
Boissons	core-ingredient	12
Coffees	core-ingredient	12
Green teas	core-ingredient	9
Biscuits and cakes	core-ingredient	9
en:Waters	core-ingredient	9
Fruits	core-ingredient	9
Gelatin	core-ingredient	9
Thickeners	core-ingredient	9
en:Sweetened beverages	core-ingredient	9
Sugar-free chewing gum	core-ingredient	8
Iced teas with lemonade	core-ingredient	8
en:artificially-sweetened-beverages	core-ingredient	7
Still fruit soft drinks	core-ingredient	7
Breakfasts	core-ingredient	6
Boissons édulcorées	core-ingredient	6
gazeuses	core-ingredient	6
Cooking helpers	core-ingredient	6
Peaches	core-ingredient	6
Juices and nectars	core-ingredient	6
Non-alcoholic beverages	core-ingredient	6
Maple syrups	core-ingredient	6
Candies	core-ingredient	5
en:diet-cola-soft-drink	core-ingredient	5
en:Sodas	core-ingredient	5
Biscuits	core-ingredient	5
Peaches in syrup	core-ingredient	5
Fruits in syrup	core-ingredient	5
Whey powder	core-ingredient	5
Baking decorations	core-ingredient	5
Alcoholic beverages	core-ingredient	5
Flavoured milks	core-ingredient	5
Dairy drinks	core-ingredient	5
Breakfast cereals	core-ingredient	4
Sodas au cola light	core-ingredient	4
Sodas light	core-ingredient	4
Sodas au cola	core-ingredient	4
Boissons light	core-ingredient	4
Fruit juices	core-ingredient	4
Decaffeinated teas	core-ingredient	4
en:sweetened-beverages	core-ingredient	4
Protein	core-ingredient	4
Flavors	core-ingredient	4
Aloe Vera drinks	core-ingredient	3
Ice creams	core-ingredient	3
Ice creams and sorbets	core-ingredient	3
en:iced-teas	core-ingredient	3
en:Carbonated drinks	core-ingredient	3
Ice pops	core-ingredient	3
Mandarin oranges	core-ingredient	3
Citrus	core-ingredient	3
Iced teas with raspberry flavor	core-ingredient	3
Siropes aromatizados	core-ingredient	3
Root beers	core-ingredient	3
Bebidas	core-ingredient	3
Unsweetened beverages	core-ingredient	3
Chocolate milks	core-ingredient	3
Almonds	core-ingredient	2
Nuts	core-ingredient	2
Nuts and their products	core-ingredient	2
Ice cream sandwiches	core-ingredient	2
Dessert mixes	core-ingredient	2
Cakes	core-ingredient	2
énergisantes	core-ingredient	2
Tea bags	core-ingredient	2
Groceries	core-ingredient	2
Sauces	core-ingredient	2
Condiments	core-ingredient	2
Instant beverages	core-ingredient	2
Tonic water	core-ingredient	2
Breads	core-ingredient	2
Iced coffees	core-ingredient	2
Coffee drinks	core-ingredient	2
en:Concentrate syrup without sugar and with artificial sweeteners	core-ingredient	2
en:Sugar-free flavoured syrups	core-ingredient	2
Siropes	core-ingredient	2
Puddings	core-ingredient	2
Boissons gazeuses	core-ingredient	2
Sports Drink	core-ingredient	2
Licensed products	core-ingredient	2
Specific products	core-ingredient	2
Jugos	core-ingredient	2
Flavoured syrups	core-ingredient	2
protein shake	core-ingredient	2
en:protein-shakes	core-ingredient	2
Protien Drink	core-ingredient	2
en:protein-powders	core-ingredient	2
en:Plant-based foods and beverages	core-ingredient	2
Electrolyte	core-ingredient	2
Energy Drink	core-ingredient	2
en:dietary-supplements	core-ingredient	2
BCAA	core-ingredient	2
Low calorie meal replacement	core-ingredient	1
Meal replacements	core-ingredient	1
Meals	core-ingredient	1
Snacks Snacks sucrés Confiseries	core-ingredient	1
Zero Calorie Sodas	core-ingredient	1
Diet colas	core-ingredient	1
Soft drinks	core-ingredient	1
Fruit sodas	core-ingredient	1
Drinks	core-ingredient	1
en:simple-syrups	core-ingredient	1
Cake mixes	core-ingredient	1
Baking Mixes	core-ingredient	1
Pastry helpers	core-ingredient	1
Blueberry pies	core-ingredient	1
Pies	core-ingredient	1
Fruit tarts	core-ingredient	1
Sweet pies	core-ingredient	1
Pineapple in juice	core-ingredient	1
Chocolate powders	core-ingredient	1
Cocoa and chocolate powders	core-ingredient	1
Cocoa and its products	core-ingredient	1
Multifruit juices from concentrate	core-ingredient	1
Flavoured Drinks	core-ingredient	1
Fat free yogurt	core-ingredient	1
Fruit yogurts	core-ingredient	1
Fermented dairy desserts with fruits	core-ingredient	1
Breakfast	core-ingredient	1
Boissons lyophilisées	core-ingredient	1
Produits lyophilisés à reconstituer	core-ingredient	1
Produits déshydratés	core-ingredient	1
Fruit and vegetable preserves	core-ingredient	1
Sweet spreads	core-ingredient	1
Plant-based spreads	core-ingredient	1
Spreads	core-ingredient	1
Siropes simples	core-ingredient	1
Endulzantes	core-ingredient	1
Water flavoring	core-ingredient	1
Boisson concentrée à diluer sans sucres ajoutés avec édulcorants	core-ingredient	1
Sirops	core-ingredient	1
en:dessert-mixes	core-ingredient	1
Protein powder	core-ingredient	1
Boissons et préparations de boissons	core-ingredient	1
Coke Zero Sugar Caffine Free	core-ingredient	1
Coca	core-ingredient	1
Preparaciones de bebidas	core-ingredient	1
Bebidas y preparaciones de bebidas	core-ingredient	1
Electrolyte-drink-mix	core-ingredient	1
Propel fitness water	core-ingredient	1
es:Gatorade	core-ingredient	1
Powdered drink	core-ingredient	1
Boissons avec sucre ajouté	core-ingredient	1
édulcorées	core-ingredient	1
Shortbread cookies	core-ingredient	1
Mixes for jelly desserts	core-ingredient	1
Bevande senza zucchero	core-ingredient	1
Wheat breads	core-ingredient	1
White breads	core-ingredient	1
drink mix powder	core-ingredient	1
Singles to go	core-ingredient	1
Apple syrups	core-ingredient	1
Cranberry juices	core-ingredient	1
Chocolate ice cream bars	core-ingredient	1
Ice cream bars	core-ingredient	1
en:Frozen desserts	core-ingredient	1
en:Frozen foods	core-ingredient	1
en:Desserts	core-ingredient	1
en:Chocolate sauce	core-ingredient	1
en:Dessert sauces	core-ingredient	1
Salsas	core-ingredient	1
Condimentos	core-ingredient	1
Brewed green tea without sugar	core-ingredient	1
Herbal teas	core-ingredient	1
fr:jus	core-ingredient	1
Tés verdes	core-ingredient	1
Tés	core-ingredient	1
Bebidas de origen vegetal	core-ingredient	1
Bebidas para tomar calientes	core-ingredient	1
Alimentos y bebidas de origen vegetal	core-ingredient	1
Bars	core-ingredient	1
Shake	core-ingredient	1
es:protenia	core-ingredient	1
Meal replacement shake	core-ingredient	1
supplaments	core-ingredient	1
Cough drops	core-ingredient	1
Protéines en poudre	core-ingredient	1
Compléments pour le Bodybuilding	core-ingredient	1
Compléments alimentaires	core-ingredient	1
Electrolytes	core-ingredient	1
en:Whey Protein	core-ingredient	1
Polvos de proteína	core-ingredient	1
Suplementos de culturismo	core-ingredient	1
Suplementos dietéticos	core-ingredient	1
Grape juices from concentrate	core-ingredient	1
Grape-sour-soft-drink	core-ingredient	1
Cow milks	core-ingredient	1
en:milks	core-ingredient	1
Vitamin waters	core-ingredient	1
en:Still fruit soft drink with sugar and with 10-50% of fruit juice	core-ingredient	1
en:Still fruit soft drinks	core-ingredient	1
en:Fruit-based beverages	core-ingredient	1
en:Plant-based beverages	core-ingredient	1
Hydration	core-ingredient	1
Mixed drinks	core-ingredient	1
Orange syrups	core-ingredient	1
Strawberry milks	core-ingredient	1
Protein drink	core-ingredient	1
Protein drinks	core-ingredient	1
Nutrition shake	core-ingredient	1
Health	core-ingredient	1
Carbonated Drink	core-ingredient	1
Drink	core-ingredient	1
Energy drink with sugar	core-ingredient	1
Chocolate reduced milk	core-ingredient	1
en:Breakfast cereals	core-ingredient	1
en:Cereals and their products	core-ingredient	1
en:Cereals and potatoes	core-ingredient	1
en:Breakfasts	core-ingredient	1
en:Plant-based foods	core-ingredient	1
Milkshake	core-ingredient	1
Protien powder	core-ingredient	1
Boissons énergisantes	core-ingredient	1
Sirop sans sucre aromatisés au fruit de la passion	core-ingredient	1
Substitut nicotinique	core-ingredient	1
Maiustused	core-ingredient	1
en:Chewing gum	core-ingredient	1
en:Candies	core-ingredient	1
en:Confectioneries	core-ingredient	1
en:Sweet snacks	core-ingredient	1
en:Snacks	core-ingredient	1
en:Protéines en poudre	core-ingredient	1
en:Compléments pour le Bodybuilding	core-ingredient	1
en:Compléments alimentaires	core-ingredient	1
Powdered Juice Drink	core-ingredient	1
Sugar free instant Ice Teas	core-ingredient	1
en:green-teas	core-ingredient	1
Sugar-free beverages	core-ingredient	1
Powdered Ice Teas	core-ingredient	1
Enhaned water	core-ingredient	1
Orange nectars	core-ingredient	1
Fruit nectars	core-ingredient	1
Digestives	core-ingredient	1
Boissons aux fruits	core-ingredient	1
Boissons à base de végétaux	core-ingredient	1
Aliments et boissons à base de végétaux	core-ingredient	1
Stevia sweetener	core-ingredient	1
Artificial sugar substitutes	core-ingredient	1
Sugar substitutes	core-ingredient	1
Soda can	core-ingredient	1
es:Refresco	core-ingredient	1
Kiwi fruit juice	core-ingredient	1
nl:Aardbeiennectars	core-ingredient	1
fr:Boissons concentrées	core-ingredient	1
Instant Iced Tea Apple flavor	core-ingredient	1
en:Diet cola soft drink	core-ingredient	1
en:Diet sodas	core-ingredient	1
en:Colas	core-ingredient	1
en:Diet beverages	core-ingredient	1
en:Artificially sweetened beverages	core-ingredient	1
Powdered juice drink mix	core-ingredient	1
Biscuits diététiques	core-ingredient	1
Sodas aux fruits exotiques	core-ingredient	1
Boissons gazeuses non sucrées aux fruits avec 10 à 50% de jus	core-ingredient	1

Class	Description
sulfuric acid derivative
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (17)

Potency Measurements

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
interleukin 8	Homo sapiens (human)	Potency	74.9780	0.0473	49.4806	74.9780	AID651758
acetylcholinesterase	Homo sapiens (human)	Potency	28.3268	0.0025	41.7960	15,848.9004	AID1347395
AR protein	Homo sapiens (human)	Potency	2.3670	0.0002	21.2231	8,912.5098	AID588515; AID743042
nuclear receptor subfamily 1, group I, member 3	Homo sapiens (human)	Potency	48.6565	0.0010	22.6508	76.6163	AID1224838; AID1224893
glucocorticoid receptor [Homo sapiens]	Homo sapiens (human)	Potency	7.0795	0.0002	14.3764	60.0339	AID588532
retinoic acid nuclear receptor alpha variant 1	Homo sapiens (human)	Potency	27.3616	0.0030	41.6115	22,387.1992	AID1159552
estrogen-related nuclear receptor alpha	Homo sapiens (human)	Potency	46.7686	0.0015	30.6073	15,848.9004	AID1224841; AID1224842; AID1224848; AID1224849; AID1259401; AID1259403
estrogen nuclear receptor alpha	Homo sapiens (human)	Potency	25.1144	0.0002	29.3054	16,493.5996	AID588514; AID743069; AID743075
vitamin D (1,25- dihydroxyvitamin D3) receptor	Homo sapiens (human)	Potency	0.0022	0.0237	23.2282	63.5986	AID588543
thyroid hormone receptor beta isoform a	Homo sapiens (human)	Potency	1.5849	0.0100	39.5371	1,122.0200	AID588547
histone-lysine N-methyltransferase 2A isoform 2 precursor	Homo sapiens (human)	Potency	112.2020	0.0103	23.8567	63.0957	AID2662
Cellular tumor antigen p53	Homo sapiens (human)	Potency	20.7585	0.0023	19.5956	74.0614	AID651631; AID651743
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Carbonic anhydrase 12	Homo sapiens (human)	Ki	20.0000	0.0002	1.1043	9.9000	AID1183562; AID1275627; AID1472890
Carbonic anhydrase 1	Homo sapiens (human)	Ki	20.0000	0.0000	1.3726	10.0000	AID1183559; AID1275624; AID1472887
Carbonic anhydrase 2	Homo sapiens (human)	Ki	20.0000	0.0000	0.7236	9.9200	AID1183560; AID1275625; AID1472888
Carbonic anhydrase 9	Homo sapiens (human)	Ki	2.4067	0.0001	0.7874	9.9000	AID1183561; AID1275626; AID1472889
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Taste receptor type 2 member 31	Homo sapiens (human)	EC50 (µMol)	3,000.0000	0.0049	0.0049	0.0049	AID1619474
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Other Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (143)

Process	via Protein(s)	Taxonomy
estrous cycle	Carbonic anhydrase 12	Homo sapiens (human)
chloride ion homeostasis	Carbonic anhydrase 12	Homo sapiens (human)
one-carbon metabolic process	Carbonic anhydrase 12	Homo sapiens (human)
one-carbon metabolic process	Carbonic anhydrase 1	Homo sapiens (human)
morphogenesis of an epithelium	Carbonic anhydrase 2	Homo sapiens (human)
positive regulation of synaptic transmission, GABAergic	Carbonic anhydrase 2	Homo sapiens (human)
positive regulation of cellular pH reduction	Carbonic anhydrase 2	Homo sapiens (human)
angiotensin-activated signaling pathway	Carbonic anhydrase 2	Homo sapiens (human)
regulation of monoatomic anion transport	Carbonic anhydrase 2	Homo sapiens (human)
secretion	Carbonic anhydrase 2	Homo sapiens (human)
regulation of intracellular pH	Carbonic anhydrase 2	Homo sapiens (human)
neuron cellular homeostasis	Carbonic anhydrase 2	Homo sapiens (human)
positive regulation of dipeptide transmembrane transport	Carbonic anhydrase 2	Homo sapiens (human)
regulation of chloride transport	Carbonic anhydrase 2	Homo sapiens (human)
carbon dioxide transport	Carbonic anhydrase 2	Homo sapiens (human)
one-carbon metabolic process	Carbonic anhydrase 2	Homo sapiens (human)
negative regulation of cell population proliferation	Cellular tumor antigen p53	Homo sapiens (human)
regulation of cell cycle	Cellular tumor antigen p53	Homo sapiens (human)
regulation of cell cycle G2/M phase transition	Cellular tumor antigen p53	Homo sapiens (human)
DNA damage response	Cellular tumor antigen p53	Homo sapiens (human)
ER overload response	Cellular tumor antigen p53	Homo sapiens (human)
cellular response to glucose starvation	Cellular tumor antigen p53	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Cellular tumor antigen p53	Homo sapiens (human)
regulation of apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of miRNA transcription	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Cellular tumor antigen p53	Homo sapiens (human)
mitophagy	Cellular tumor antigen p53	Homo sapiens (human)
in utero embryonic development	Cellular tumor antigen p53	Homo sapiens (human)
somitogenesis	Cellular tumor antigen p53	Homo sapiens (human)
release of cytochrome c from mitochondria	Cellular tumor antigen p53	Homo sapiens (human)
hematopoietic progenitor cell differentiation	Cellular tumor antigen p53	Homo sapiens (human)
T cell proliferation involved in immune response	Cellular tumor antigen p53	Homo sapiens (human)
B cell lineage commitment	Cellular tumor antigen p53	Homo sapiens (human)
T cell lineage commitment	Cellular tumor antigen p53	Homo sapiens (human)
response to ischemia	Cellular tumor antigen p53	Homo sapiens (human)
nucleotide-excision repair	Cellular tumor antigen p53	Homo sapiens (human)
double-strand break repair	Cellular tumor antigen p53	Homo sapiens (human)
regulation of DNA-templated transcription	Cellular tumor antigen p53	Homo sapiens (human)
regulation of transcription by RNA polymerase II	Cellular tumor antigen p53	Homo sapiens (human)
protein import into nucleus	Cellular tumor antigen p53	Homo sapiens (human)
autophagy	Cellular tumor antigen p53	Homo sapiens (human)
DNA damage response	Cellular tumor antigen p53	Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	Cellular tumor antigen p53	Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	Cellular tumor antigen p53	Homo sapiens (human)
transforming growth factor beta receptor signaling pathway	Cellular tumor antigen p53	Homo sapiens (human)
Ras protein signal transduction	Cellular tumor antigen p53	Homo sapiens (human)
gastrulation	Cellular tumor antigen p53	Homo sapiens (human)
neuroblast proliferation	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of neuroblast proliferation	Cellular tumor antigen p53	Homo sapiens (human)
protein localization	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of DNA replication	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of cell population proliferation	Cellular tumor antigen p53	Homo sapiens (human)
determination of adult lifespan	Cellular tumor antigen p53	Homo sapiens (human)
mRNA transcription	Cellular tumor antigen p53	Homo sapiens (human)
rRNA transcription	Cellular tumor antigen p53	Homo sapiens (human)
response to salt stress	Cellular tumor antigen p53	Homo sapiens (human)
response to inorganic substance	Cellular tumor antigen p53	Homo sapiens (human)
response to X-ray	Cellular tumor antigen p53	Homo sapiens (human)
response to gamma radiation	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of gene expression	Cellular tumor antigen p53	Homo sapiens (human)
cardiac muscle cell apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of cardiac muscle cell apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
glial cell proliferation	Cellular tumor antigen p53	Homo sapiens (human)
viral process	Cellular tumor antigen p53	Homo sapiens (human)
glucose catabolic process to lactate via pyruvate	Cellular tumor antigen p53	Homo sapiens (human)
cerebellum development	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of cell growth	Cellular tumor antigen p53	Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of transforming growth factor beta receptor signaling pathway	Cellular tumor antigen p53	Homo sapiens (human)
mitotic G1 DNA damage checkpoint signaling	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of telomere maintenance via telomerase	Cellular tumor antigen p53	Homo sapiens (human)
T cell differentiation in thymus	Cellular tumor antigen p53	Homo sapiens (human)
tumor necrosis factor-mediated signaling pathway	Cellular tumor antigen p53	Homo sapiens (human)
regulation of tissue remodeling	Cellular tumor antigen p53	Homo sapiens (human)
cellular response to UV	Cellular tumor antigen p53	Homo sapiens (human)
multicellular organism growth	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of mitochondrial membrane permeability	Cellular tumor antigen p53	Homo sapiens (human)
cellular response to glucose starvation	Cellular tumor antigen p53	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
entrainment of circadian clock by photoperiod	Cellular tumor antigen p53	Homo sapiens (human)
mitochondrial DNA repair	Cellular tumor antigen p53	Homo sapiens (human)
regulation of DNA damage response, signal transduction by p53 class mediator	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of neuron apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
transcription initiation-coupled chromatin remodeling	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of proteolysis	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of DNA-templated transcription	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of DNA-templated transcription	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of RNA polymerase II transcription preinitiation complex assembly	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Cellular tumor antigen p53	Homo sapiens (human)
response to antibiotic	Cellular tumor antigen p53	Homo sapiens (human)
fibroblast proliferation	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of fibroblast proliferation	Cellular tumor antigen p53	Homo sapiens (human)
circadian behavior	Cellular tumor antigen p53	Homo sapiens (human)
bone marrow development	Cellular tumor antigen p53	Homo sapiens (human)
embryonic organ development	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylation	Cellular tumor antigen p53	Homo sapiens (human)
protein stabilization	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of helicase activity	Cellular tumor antigen p53	Homo sapiens (human)
protein tetramerization	Cellular tumor antigen p53	Homo sapiens (human)
chromosome organization	Cellular tumor antigen p53	Homo sapiens (human)
neuron apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
regulation of cell cycle	Cellular tumor antigen p53	Homo sapiens (human)
hematopoietic stem cell differentiation	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of glial cell proliferation	Cellular tumor antigen p53	Homo sapiens (human)
type II interferon-mediated signaling pathway	Cellular tumor antigen p53	Homo sapiens (human)
cardiac septum morphogenesis	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of programmed necrotic cell death	Cellular tumor antigen p53	Homo sapiens (human)
protein-containing complex assembly	Cellular tumor antigen p53	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	Cellular tumor antigen p53	Homo sapiens (human)
thymocyte apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of thymocyte apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
necroptotic process	Cellular tumor antigen p53	Homo sapiens (human)
cellular response to hypoxia	Cellular tumor antigen p53	Homo sapiens (human)
cellular response to xenobiotic stimulus	Cellular tumor antigen p53	Homo sapiens (human)
cellular response to ionizing radiation	Cellular tumor antigen p53	Homo sapiens (human)
cellular response to gamma radiation	Cellular tumor antigen p53	Homo sapiens (human)
cellular response to UV-C	Cellular tumor antigen p53	Homo sapiens (human)
stem cell proliferation	Cellular tumor antigen p53	Homo sapiens (human)
signal transduction by p53 class mediator	Cellular tumor antigen p53	Homo sapiens (human)
intrinsic apoptotic signaling pathway by p53 class mediator	Cellular tumor antigen p53	Homo sapiens (human)
reactive oxygen species metabolic process	Cellular tumor antigen p53	Homo sapiens (human)
cellular response to actinomycin D	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of release of cytochrome c from mitochondria	Cellular tumor antigen p53	Homo sapiens (human)
cellular senescence	Cellular tumor antigen p53	Homo sapiens (human)
replicative senescence	Cellular tumor antigen p53	Homo sapiens (human)
oxidative stress-induced premature senescence	Cellular tumor antigen p53	Homo sapiens (human)
intrinsic apoptotic signaling pathway	Cellular tumor antigen p53	Homo sapiens (human)
oligodendrocyte apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of execution phase of apoptosis	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of mitophagy	Cellular tumor antigen p53	Homo sapiens (human)
regulation of mitochondrial membrane permeability involved in apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
regulation of intrinsic apoptotic signaling pathway by p53 class mediator	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of miRNA transcription	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of G1 to G0 transition	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of miRNA processing	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of glucose catabolic process to lactate via pyruvate	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of pentose-phosphate shunt	Cellular tumor antigen p53	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to hypoxia	Cellular tumor antigen p53	Homo sapiens (human)
regulation of fibroblast apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of reactive oxygen species metabolic process	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of reactive oxygen species metabolic process	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of stem cell proliferation	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of cellular senescence	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of intrinsic apoptotic signaling pathway	Cellular tumor antigen p53	Homo sapiens (human)
detection of chemical stimulus involved in sensory perception of bitter taste	Taste receptor type 2 member 31	Homo sapiens (human)
G protein-coupled receptor signaling pathway	Taste receptor type 2 member 31	Homo sapiens (human)
response to hypoxia	Carbonic anhydrase 9	Homo sapiens (human)
morphogenesis of an epithelium	Carbonic anhydrase 9	Homo sapiens (human)
response to xenobiotic stimulus	Carbonic anhydrase 9	Homo sapiens (human)
response to testosterone	Carbonic anhydrase 9	Homo sapiens (human)
secretion	Carbonic anhydrase 9	Homo sapiens (human)
one-carbon metabolic process	Carbonic anhydrase 9	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (40)

Process	via Protein(s)	Taxonomy
zinc ion binding	Carbonic anhydrase 12	Homo sapiens (human)
carbonate dehydratase activity	Carbonic anhydrase 12	Homo sapiens (human)
arylesterase activity	Carbonic anhydrase 1	Homo sapiens (human)
carbonate dehydratase activity	Carbonic anhydrase 1	Homo sapiens (human)
protein binding	Carbonic anhydrase 1	Homo sapiens (human)
zinc ion binding	Carbonic anhydrase 1	Homo sapiens (human)
hydro-lyase activity	Carbonic anhydrase 1	Homo sapiens (human)
cyanamide hydratase activity	Carbonic anhydrase 1	Homo sapiens (human)
arylesterase activity	Carbonic anhydrase 2	Homo sapiens (human)
carbonate dehydratase activity	Carbonic anhydrase 2	Homo sapiens (human)
protein binding	Carbonic anhydrase 2	Homo sapiens (human)
zinc ion binding	Carbonic anhydrase 2	Homo sapiens (human)
cyanamide hydratase activity	Carbonic anhydrase 2	Homo sapiens (human)
transcription cis-regulatory region binding	Cellular tumor antigen p53	Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Cellular tumor antigen p53	Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specific	Cellular tumor antigen p53	Homo sapiens (human)
cis-regulatory region sequence-specific DNA binding	Cellular tumor antigen p53	Homo sapiens (human)
core promoter sequence-specific DNA binding	Cellular tumor antigen p53	Homo sapiens (human)
TFIID-class transcription factor complex binding	Cellular tumor antigen p53	Homo sapiens (human)
DNA-binding transcription repressor activity, RNA polymerase II-specific	Cellular tumor antigen p53	Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specific	Cellular tumor antigen p53	Homo sapiens (human)
protease binding	Cellular tumor antigen p53	Homo sapiens (human)
p53 binding	Cellular tumor antigen p53	Homo sapiens (human)
DNA binding	Cellular tumor antigen p53	Homo sapiens (human)
chromatin binding	Cellular tumor antigen p53	Homo sapiens (human)
DNA-binding transcription factor activity	Cellular tumor antigen p53	Homo sapiens (human)
mRNA 3'-UTR binding	Cellular tumor antigen p53	Homo sapiens (human)
copper ion binding	Cellular tumor antigen p53	Homo sapiens (human)
protein binding	Cellular tumor antigen p53	Homo sapiens (human)
zinc ion binding	Cellular tumor antigen p53	Homo sapiens (human)
enzyme binding	Cellular tumor antigen p53	Homo sapiens (human)
receptor tyrosine kinase binding	Cellular tumor antigen p53	Homo sapiens (human)
ubiquitin protein ligase binding	Cellular tumor antigen p53	Homo sapiens (human)
histone deacetylase regulator activity	Cellular tumor antigen p53	Homo sapiens (human)
ATP-dependent DNA/DNA annealing activity	Cellular tumor antigen p53	Homo sapiens (human)
identical protein binding	Cellular tumor antigen p53	Homo sapiens (human)
histone deacetylase binding	Cellular tumor antigen p53	Homo sapiens (human)
protein heterodimerization activity	Cellular tumor antigen p53	Homo sapiens (human)
protein-folding chaperone binding	Cellular tumor antigen p53	Homo sapiens (human)
protein phosphatase 2A binding	Cellular tumor antigen p53	Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor binding	Cellular tumor antigen p53	Homo sapiens (human)
14-3-3 protein binding	Cellular tumor antigen p53	Homo sapiens (human)
MDM2/MDM4 family protein binding	Cellular tumor antigen p53	Homo sapiens (human)
disordered domain specific binding	Cellular tumor antigen p53	Homo sapiens (human)
general transcription initiation factor binding	Cellular tumor antigen p53	Homo sapiens (human)
molecular function activator activity	Cellular tumor antigen p53	Homo sapiens (human)
promoter-specific chromatin binding	Cellular tumor antigen p53	Homo sapiens (human)
G protein-coupled receptor activity	Taste receptor type 2 member 31	Homo sapiens (human)
bitter taste receptor activity	Taste receptor type 2 member 31	Homo sapiens (human)
carbonate dehydratase activity	Carbonic anhydrase 9	Homo sapiens (human)
protein binding	Carbonic anhydrase 9	Homo sapiens (human)
zinc ion binding	Carbonic anhydrase 9	Homo sapiens (human)
molecular function activator activity	Carbonic anhydrase 9	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (27)

Process	via Protein(s)	Taxonomy
plasma membrane	Carbonic anhydrase 12	Homo sapiens (human)
membrane	Carbonic anhydrase 12	Homo sapiens (human)
basolateral plasma membrane	Carbonic anhydrase 12	Homo sapiens (human)
apical plasma membrane	Carbonic anhydrase 12	Homo sapiens (human)
plasma membrane	Carbonic anhydrase 12	Homo sapiens (human)
cytosol	Carbonic anhydrase 1	Homo sapiens (human)
extracellular exosome	Carbonic anhydrase 1	Homo sapiens (human)
cytoplasm	Carbonic anhydrase 2	Homo sapiens (human)
cytosol	Carbonic anhydrase 2	Homo sapiens (human)
plasma membrane	Carbonic anhydrase 2	Homo sapiens (human)
myelin sheath	Carbonic anhydrase 2	Homo sapiens (human)
apical part of cell	Carbonic anhydrase 2	Homo sapiens (human)
extracellular exosome	Carbonic anhydrase 2	Homo sapiens (human)
cytoplasm	Carbonic anhydrase 2	Homo sapiens (human)
plasma membrane	Carbonic anhydrase 2	Homo sapiens (human)
apical part of cell	Carbonic anhydrase 2	Homo sapiens (human)
nuclear body	Cellular tumor antigen p53	Homo sapiens (human)
nucleus	Cellular tumor antigen p53	Homo sapiens (human)
nucleoplasm	Cellular tumor antigen p53	Homo sapiens (human)
replication fork	Cellular tumor antigen p53	Homo sapiens (human)
nucleolus	Cellular tumor antigen p53	Homo sapiens (human)
cytoplasm	Cellular tumor antigen p53	Homo sapiens (human)
mitochondrion	Cellular tumor antigen p53	Homo sapiens (human)
mitochondrial matrix	Cellular tumor antigen p53	Homo sapiens (human)
endoplasmic reticulum	Cellular tumor antigen p53	Homo sapiens (human)
centrosome	Cellular tumor antigen p53	Homo sapiens (human)
cytosol	Cellular tumor antigen p53	Homo sapiens (human)
nuclear matrix	Cellular tumor antigen p53	Homo sapiens (human)
PML body	Cellular tumor antigen p53	Homo sapiens (human)
transcription repressor complex	Cellular tumor antigen p53	Homo sapiens (human)
site of double-strand break	Cellular tumor antigen p53	Homo sapiens (human)
germ cell nucleus	Cellular tumor antigen p53	Homo sapiens (human)
chromatin	Cellular tumor antigen p53	Homo sapiens (human)
transcription regulator complex	Cellular tumor antigen p53	Homo sapiens (human)
protein-containing complex	Cellular tumor antigen p53	Homo sapiens (human)
plasma membrane	Taste receptor type 2 member 31	Homo sapiens (human)
membrane	Taste receptor type 2 member 31	Homo sapiens (human)
membrane	Taste receptor type 2 member 31	Homo sapiens (human)
nucleolus	Carbonic anhydrase 9	Homo sapiens (human)
plasma membrane	Carbonic anhydrase 9	Homo sapiens (human)
membrane	Carbonic anhydrase 9	Homo sapiens (human)
basolateral plasma membrane	Carbonic anhydrase 9	Homo sapiens (human)
microvillus membrane	Carbonic anhydrase 9	Homo sapiens (human)
plasma membrane	Carbonic anhydrase 9	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (26)

Assay ID	Title	Year	Journal	Article
AID1296008	Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening	2020	SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1	Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1346987	P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346986	P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID504749	qHTS profiling for inhibitors of Plasmodium falciparum proliferation	2011	Science (New York, N.Y.), Aug-05, Volume: 333, Issue:6043	Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.
AID1472893	Selectivity index, ratio of Ki for recombinant human carbonic anhydrase 12 to Ki for recombinant human carbonic anhydrase 9	2018	Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3	"Seriously Sweet": Acesulfame K Exhibits Selective Inhibition Using Alternative Binding Modes in Carbonic Anhydrase Isoforms.
AID1472892	Selectivity index, ratio of Ki for recombinant human carbonic anhydrase 2 to Ki for recombinant human carbonic anhydrase 9	2018	Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3	"Seriously Sweet": Acesulfame K Exhibits Selective Inhibition Using Alternative Binding Modes in Carbonic Anhydrase Isoforms.
AID1472889	Inhibition of recombinant human carbonic anhydrase 9 expressed in Escherichia coli L21-GOLD (DE3) incubated for 10 mins prior to testing by stopped-flow CO2 hydration assay	2018	Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3	"Seriously Sweet": Acesulfame K Exhibits Selective Inhibition Using Alternative Binding Modes in Carbonic Anhydrase Isoforms.
AID1472890	Inhibition of recombinant human carbonic anhydrase 12 expressed in Escherichia coli L21-GOLD (DE3) incubated for 10 mins prior to testing by stopped-flow CO2 hydration assay	2018	Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3	"Seriously Sweet": Acesulfame K Exhibits Selective Inhibition Using Alternative Binding Modes in Carbonic Anhydrase Isoforms.
AID1472891	Selectivity index, ratio of Ki for recombinant human carbonic anhydrase 1 to Ki for recombinant human carbonic anhydrase 9	2018	Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3	"Seriously Sweet": Acesulfame K Exhibits Selective Inhibition Using Alternative Binding Modes in Carbonic Anhydrase Isoforms.
AID1183559	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration method	2014	European journal of medicinal chemistry, Sep-12, Volume: 84	Cyclic tertiary sulfamates: selective inhibition of the tumor-associated carbonic anhydrases IX and XII by N- and O-substituted acesulfame derivatives.
AID1275625	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	2016	Bioorganic & medicinal chemistry, Mar-01, Volume: 24, Issue:5	A novel library of saccharin and acesulfame derivatives as potent and selective inhibitors of carbonic anhydrase IX and XII isoforms.
AID1472888	Inhibition of recombinant human carbonic anhydrase 2 expressed in Escherichia coli L21-GOLD (DE3) incubated for 10 mins prior to testing by stopped-flow CO2 hydration assay	2018	Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3	"Seriously Sweet": Acesulfame K Exhibits Selective Inhibition Using Alternative Binding Modes in Carbonic Anhydrase Isoforms.
AID665434	Anticonvulsant activity against maximal electroshock-induced seizures in Swiss mouse at 30 mg/kg, ip after 4 hrs	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	Anticonvulsant activity of artificial sweeteners: a structural link between sweet-taste receptor T1R3 and brain glutamate receptors.
AID665433	Anticonvulsant activity against maximal electroshock-induced seizures in Swiss mouse at 300 mg/kg, ip after 0.5 hrs	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	Anticonvulsant activity of artificial sweeteners: a structural link between sweet-taste receptor T1R3 and brain glutamate receptors.
AID1183561	Inhibition of human recombinant carbonic anhydrase 9 by stopped flow CO2 hydration method	2014	European journal of medicinal chemistry, Sep-12, Volume: 84	Cyclic tertiary sulfamates: selective inhibition of the tumor-associated carbonic anhydrases IX and XII by N- and O-substituted acesulfame derivatives.
AID665437	Neurotoxicity against Swiss mouse at 30 to 300 mg/kg, ip after 4 hrs by rotarod ataxia test	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	Anticonvulsant activity of artificial sweeteners: a structural link between sweet-taste receptor T1R3 and brain glutamate receptors.
AID665435	Anticonvulsant activity against maximal electroshock-induced seizures in Swiss mouse at 100 mg/kg, ip after 4 hrs	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	Anticonvulsant activity of artificial sweeteners: a structural link between sweet-taste receptor T1R3 and brain glutamate receptors.
AID1275626	Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assay	2016	Bioorganic & medicinal chemistry, Mar-01, Volume: 24, Issue:5	A novel library of saccharin and acesulfame derivatives as potent and selective inhibitors of carbonic anhydrase IX and XII isoforms.
AID665436	Anticonvulsant activity against maximal electroshock-induced seizures in Swiss mouse at 300 mg/kg, ip after 4 hrs	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	Anticonvulsant activity of artificial sweeteners: a structural link between sweet-taste receptor T1R3 and brain glutamate receptors.
AID1275627	Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assay	2016	Bioorganic & medicinal chemistry, Mar-01, Volume: 24, Issue:5	A novel library of saccharin and acesulfame derivatives as potent and selective inhibitors of carbonic anhydrase IX and XII isoforms.
AID1472887	Inhibition of recombinant human carbonic anhydrase 1 expressed in Escherichia coli L21-GOLD (DE3) incubated for 10 mins prior to testing by stopped-flow CO2 hydration assay	2018	Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3	"Seriously Sweet": Acesulfame K Exhibits Selective Inhibition Using Alternative Binding Modes in Carbonic Anhydrase Isoforms.
AID1275624	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	2016	Bioorganic & medicinal chemistry, Mar-01, Volume: 24, Issue:5	A novel library of saccharin and acesulfame derivatives as potent and selective inhibitors of carbonic anhydrase IX and XII isoforms.
AID1183560	Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration method	2014	European journal of medicinal chemistry, Sep-12, Volume: 84	Cyclic tertiary sulfamates: selective inhibition of the tumor-associated carbonic anhydrases IX and XII by N- and O-substituted acesulfame derivatives.
AID665431	Anticonvulsant activity against maximal electroshock-induced seizures in Swiss mouse at 100 mg/kg, ip after 0.5 hrs	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	Anticonvulsant activity of artificial sweeteners: a structural link between sweet-taste receptor T1R3 and brain glutamate receptors.
AID665432	Anticonvulsant activity against maximal electroshock-induced seizures in Swiss mouse at 30 mg/kg, ip after 0.5 hrs	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	Anticonvulsant activity of artificial sweeteners: a structural link between sweet-taste receptor T1R3 and brain glutamate receptors.
AID1183562	Inhibition of human recombinant carbonic anhydrase 12 by stopped flow CO2 hydration method	2014	European journal of medicinal chemistry, Sep-12, Volume: 84	Cyclic tertiary sulfamates: selective inhibition of the tumor-associated carbonic anhydrases IX and XII by N- and O-substituted acesulfame derivatives.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	6 (85.71)	24.3611
2020's	1 (14.29)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
acetazolamide Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)	2.52	2	monocarboxylic acid amide; sulfonamide; thiadiazoles	anticonvulsant; diuretic; EC 4.2.1.1 (carbonic anhydrase) inhibitor
saccharin Saccharin: Flavoring agent and non-nutritive sweetener.. saccharin : A 1,2-benzisothiazole having a keto-group at the 3-position and two oxo substituents at the 1-position. It is used as an artificial sweetening agent.	2.81	3	1,2-benzisothiazole; N-sulfonylcarboxamide	environmental contaminant; sweetening agent; xenobiotic
phthalimidine phthalimidine: structure given in first source. isoindolin-1-one : A member of the class of isoindoles that is 2,3-dihydro-1H-isoindole in which the hydrogens at positon 1 are replaced by an oxo group.	2.13	1	gamma-lactam; isoindoles
n-phthalylglycine [no description available]	2.13	1

Condition	Indicated	Relationship Strength	Studies	Trials
Absence Seizure [description not available]	0	2.07	1	0
Seizures Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.	0	2.07	1	0

acesulfame potassium

Cross-References

Synonyms (55)

Research Excerpts

Bioavailability

Occurs in Manufacturing (318 Items)

Drug Classes (1)

Protein Targets (17)

Potency Measurements

Inhibition Measurements

Activation Measurements

Other Measurements

Biological Processes (143)

Molecular Functions (40)

Ceullar Components (27)

Bioassays (26)

Research

Studies (7)

Market Indicators

Research Demand Index: 105.32

Study Types

acesulfame potassium

Cross-References

Synonyms (55)

Research Excerpts

Bioavailability

Occurs in Manufacturing (318 Items)

Drug Classes (1)

Protein Targets (17)

Potency Measurements

Inhibition Measurements

Activation Measurements

Other Measurements

Biological Processes (143)

Molecular Functions (40)

Ceullar Components (27)

Bioassays (26)

Research

Studies (7)

Market Indicators

Research Demand Index: 105.32

Study Types

Related Drugs (4)

Related Conditions (2)