Page last updated: 2024-08-05 12:18:55
crown amine
Crown compounds containing only nitrogen as coordinating atom.
ChEBI ID: 37411
Members (4)
| Member | Definition | Role |
|---|---|---|
| 1,4,7-triazacyclononane | 1,4,7-triazonane | |
| cyclam | 1,4,8,11-tetraazacyclotetradecane | |
| cyclen | An azacycloalkane that is cyclododecane in which the carbon atoms at positions 1, 4, 7 and 10 are replaced by nitrogen atoms. | 1,4,7,10-tetraazacyclododecane |
| plerixafor | An azamacrocycle consisting of two cyclam rings connected by a 1,4-phenylenebis(methylene) linker. It is a CXCR4 chemokine receptor antagonist and a hematopoietic stem cell mobilizer. It is used in combination with grulocyte-colony stimulating factor (G-CSF) to mobilize hematopoietic stem cells to the perpheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma and multiple myeloma. | plerixafor |
Research
Studies (1,742)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 8 (0.46) | 18.7374 |
| 1990's | 44 (2.53) | 18.2507 |
| 2000's | 409 (23.48) | 29.6817 |
| 2010's | 1,099 (63.09) | 24.3611 |
| 2020's | 182 (10.45) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 113 (6.29%) | 5.53% |
| Reviews | 117 (6.51%) | 6.00% |
| Case Studies | 42 (2.34%) | 4.05% |
| Observational | 7 (0.39%) | 0.25% |
| Other | 1,517 (84.47%) | 84.16% |