Page last updated: 2024-08-05 15:18:53
GABA agent
A substance, such as agonists, antagonists, degradation or uptake inhibitors, depleters, precursors, and modulators of receptor function, used for its pharmacological actions on GABAergic systems.
ChEBI ID: 51374
Members (2)
| Member | Definition | Class |
|---|---|---|
| etazolate | A pyrazolopyridine that is 1H-pyrazolo[3,4-b]pyridine which is substituted at positions 1, 4, and 5 by ethyl, 2-isopropylidenehydrazino, and ethoxycarbonyl groups, respectively. A phosphodiesterase IV inhibitor with antidepressant and anxiolytic properties. | etazolate |
| valproic acid | A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem. | valproic acid |
Research
Studies (13,255)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 2,253 (17.00) | 18.7374 |
| 1990's | 2,030 (15.31) | 18.2507 |
| 2000's | 3,411 (25.73) | 29.6817 |
| 2010's | 4,128 (31.14) | 24.3611 |
| 2020's | 1,433 (10.81) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 1,257 (8.82%) | 5.53% |
| Reviews | 1,472 (10.33%) | 6.00% |
| Case Studies | 2,398 (16.83%) | 4.05% |
| Observational | 78 (0.55%) | 0.25% |
| Other | 9,042 (63.47%) | 84.16% |
Protein Targets (84)
Potency Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| arylsulfatase A | Homo sapiens (human) | Potency | 4.2562 | 1 | 1 |
| Ataxin-2 | Homo sapiens (human) | Potency | 68.5896 | 1 | 1 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 68.5896 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 37.0051 | 1 | 2 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 39.8107 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 27.8675 | 2 | 3 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 2.5119 | 1 | 1 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 27.8675 | 2 | 3 |
| CREB-binding protein | Homo sapiens (human) | Potency | 5.4415 | 3 | 3 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 14.2191 | 2 | 4 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 43.2771 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 54.9410 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 76.5677 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 29.9349 | 1 | 1 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 41.5798 | 2 | 2 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| GLS protein | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 891.2510 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 31.6228 | 1 | 3 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 36.1254 | 1 | 1 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 18.8541 | 1 | 2 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 7.9433 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 1,412.5400 | 1 | 1 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 66.8242 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 54.2058 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 794.3280 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 501.1870 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 47.7041 | 2 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 26.6086 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 16.0014 | 2 | 2 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 0.1122 | 1 | 1 |
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Aldo-keto reductase family 1 member A1 | Bos taurus (cattle) | IC50 | 57.4000 | 1 | 1 |
| Aldo-keto reductase family 1 member A1 | Homo sapiens (human) | IC50 | 50.1000 | 1 | 1 |
| Aldo-keto reductase family 1 member A1 | Rattus norvegicus (Norway rat) | IC50 | 53.1000 | 2 | 2 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 56.1000 | 5 | 5 |
| Aldo-keto reductase family 1 member B7 | Rattus norvegicus (Norway rat) | IC50 | 56.1000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 1,000.0000 | 2 | 2 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A | Homo sapiens (human) | Ki | 60.0000 | 1 | 1 |
| Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B | Homo sapiens (human) | Ki | 60.0000 | 1 | 1 |
| Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C | Homo sapiens (human) | Ki | 60.0000 | 1 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Homo sapiens (human) | IC50 | 0.3900 | 1 | 1 |
| cGMP-inhibited 3',5'-cyclic phosphodiesterase A | Homo sapiens (human) | Ki | 12.0000 | 1 | 1 |
| cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Homo sapiens (human) | Ki | 12.0000 | 1 | 1 |
| Cocaine esterase | Homo sapiens (human) | Ki | 7,900.0000 | 1 | 1 |
| Cytochrome P450 2A6 | Homo sapiens (human) | Ki | 9,150.0000 | 1 | 1 |
| Histone deacetylase 1 | Homo sapiens (human) | IC50 | 1,262.6014 | 7 | 7 |
| Histone deacetylase 1 | Homo sapiens (human) | Ki | 564.0000 | 1 | 1 |
| Histone deacetylase 11 | Homo sapiens (human) | IC50 | 4,117.5000 | 2 | 2 |
| Histone deacetylase 11 | Homo sapiens (human) | Ki | 564.0000 | 1 | 1 |
| Histone deacetylase 2 | Homo sapiens (human) | IC50 | 1,819.9480 | 5 | 5 |
| Histone deacetylase 2 | Homo sapiens (human) | Ki | 564.0000 | 1 | 1 |
| Histone deacetylase 3 | Homo sapiens (human) | IC50 | 1,846.1340 | 5 | 5 |
| Histone deacetylase 3 | Homo sapiens (human) | Ki | 564.0000 | 1 | 1 |
| Histone deacetylase 4 | Homo sapiens (human) | IC50 | 2,808.7500 | 4 | 4 |
| Histone deacetylase 4 | Homo sapiens (human) | Ki | 564.0000 | 1 | 1 |
| Histone deacetylase 5 | Homo sapiens (human) | IC50 | 2,808.7500 | 4 | 4 |
| Histone deacetylase 5 | Homo sapiens (human) | Ki | 564.0000 | 1 | 1 |
| Histone deacetylase 6 | Homo sapiens (human) | IC50 | 2,290.0020 | 5 | 5 |
| Histone deacetylase 6 | Homo sapiens (human) | Ki | 564.0000 | 1 | 1 |
| Histone deacetylase 7 | Homo sapiens (human) | IC50 | 3,411.6667 | 3 | 3 |
| Histone deacetylase 7 | Homo sapiens (human) | Ki | 564.0000 | 1 | 1 |
| Histone deacetylase 8 | Homo sapiens (human) | IC50 | 2,130.5750 | 4 | 4 |
| Histone deacetylase 8 | Homo sapiens (human) | Ki | 564.0000 | 1 | 1 |
| Histone deacetylase 9 | Homo sapiens (human) | IC50 | 3,411.6667 | 3 | 3 |
| Histone deacetylase 9 | Homo sapiens (human) | Ki | 564.0000 | 1 | 1 |
| Liver carboxylesterase 1 | Homo sapiens (human) | Ki | 363.0000 | 1 | 1 |
| NAD-dependent protein deacylase sirtuin-5, mitochondrial | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Polyamine deacetylase HDAC10 | Homo sapiens (human) | IC50 | 4,117.5000 | 2 | 2 |
| Polyamine deacetylase HDAC10 | Homo sapiens (human) | Ki | 564.0000 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Cavia porcellus (domestic guinea pig) | Ki | 10.0000 | 1 | 1 |
| Tissue factor | Homo sapiens (human) | IC50 | 1,750.0000 | 2 | 2 |
| UDP-glucuronosyltransferase 2B7 | Homo sapiens (human) | Ki | 1,600.0000 | 1 | 1 |
Other Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| UDP-glucuronosyltransferase 1-6 | Homo sapiens (human) | Km | 3,200.0000 | 1 | 1 |
| UDP-glucuronosyltransferase 1A9 | Homo sapiens (human) | Km | 5,200.0000 | 1 | 1 |
| UDP-glucuronosyltransferase 2B7 | Homo sapiens (human) | Km | 2,100.0000 | 1 | 1 |