| Assay ID | Title | Year | Journal | Article |
|---|
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | | | |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | | | |
| AID1347108 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347106 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347097 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347091 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347102 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347098 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347090 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347096 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347104 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347099 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347407 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Pharmaceutical Collection | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7
| High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1347107 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347093 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347094 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347095 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347103 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347092 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347105 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347101 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347424 | RapidFire Mass Spectrometry qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1) | 2019 | The Journal of biological chemistry, 11-15, Volume: 294, Issue:46
| Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens. |
| AID1347089 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347425 | Rhodamine-PBP qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1) | 2019 | The Journal of biological chemistry, 11-15, Volume: 294, Issue:46
| Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens. |
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347100 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID621449 | Inhibition of equine BuChE by Ellman's method | 2011 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19
| Development of 2-substituted-N-(naphth-1-ylmethyl) and N-benzhydrylpyrimidin-4-amines as dual cholinesterase and Aβ-aggregation inhibitors: Synthesis and biological evaluation. |
| AID1357834 | Cognitive enhancing effect in Kunming mouse model of amyloid beta (1 to 42) oligomer-induced memory impairment increase in time spent in target quadrant by measuring increase in number of platform crossings at 1.3 mg/kg/day, po starting from day 1 of amyl | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Novel sarsasapogenin-triazolyl hybrids as potential anti-Alzheimer's agents: Design, synthesis and biological evaluation. |
| AID44437 | Butyrylcholinesterase | 1995 | Journal of medicinal chemistry, Nov-24, Volume: 38, Issue:24
| Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds. |
| AID1220488 | Oral bioavailability in human at 2 mg single dose | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID1220513 | Blood clearance in 7 months-old Lister Hooded rat at 1 mg/kg, iv infusion for 1 hr | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID1220479 | Inhibition of cholinesterase activity in 7 months-old Lister Hooded rat brain at 3 mg/kg, po after 1 hr treatment | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID1332153 | Effective permeability of the compound at pH 7.4 by BBB-PAMPA method | 2017 | Bioorganic & medicinal chemistry, 01-15, Volume: 25, Issue:2
| N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents. |
| AID404847 | Inhibition of human AChE assessed as reduction of thioflavin T fluorescence at 100 uM | 2008 | Journal of medicinal chemistry, Jun-26, Volume: 51, Issue:12
| Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation. |
| AID1220499 | Drug uptake in 7 months-old Lister Hooded rat blood at 3 mg/kg, po after 1 hr treatment | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID404843 | Inhibition of human erythrocyte AChE by Ellman's assay | 2008 | Journal of medicinal chemistry, Jun-26, Volume: 51, Issue:12
| Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation. |
| AID1220501 | Ratio of brain to blood in 7 months-old Lister Hooded rat blood at 3 mg/kg, po after 1 hr treatment | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID1220480 | Inhibition of cholinesterase activity in 7 months-old Lister Hooded rat plasma at 3 mg/kg, po after 1 hr treatment | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID592643 | Inhibition of human AChE-induced amyloid beta (1-40) aggregation at 100 uM after 24 hrs by thioflavin T based fluorometric assay | 2011 | Bioorganic & medicinal chemistry, Apr-01, Volume: 19, Issue:7
| Design, synthesis and structure-activity relationship (SAR) studies of 2,4-disubstituted pyrimidine derivatives: dual activity as cholinesterase and Aβ-aggregation inhibitors. |
| AID1220493 | Inhibition of cholinesterase activity in old F344 rat brain at 2.5 mg/kg, po after 1 hr treatment relative to 7 months-old Lister Hooded rat | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID1198359 | Inhibition of electric eel AChE using acetylthiocholine substrate by Ellman's reagent based method | 2015 | European journal of medicinal chemistry, Mar-26, Volume: 93 | Benzofuran-derived benzylpyridinium bromides as potent acetylcholinesterase inhibitors. |
| AID621451 | Inhibition of human AChE-induced amyloid beta (1-40) aggregation at 100 uM after 24 hrs by thioflavin T-based fluorometric assay | 2011 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19
| Development of 2-substituted-N-(naphth-1-ylmethyl) and N-benzhydrylpyrimidin-4-amines as dual cholinesterase and Aβ-aggregation inhibitors: Synthesis and biological evaluation. |
| AID1515409 | Inhibition of AChE in Swiss mouse brain homogenate using acetylthiocholine iodide as substrate by Ellman's assay | 2019 | Bioorganic & medicinal chemistry, 01-15, Volume: 27, Issue:2
| In silico, NMR and pharmacological evaluation of an hydroxyoxindole cholinesterase inhibitor. |
| AID1357832 | Toxicity in Kunming mouse model of amyloid beta (1 to 42) oligomer-induced memory impairment assessed as effect on number of arm entries at 1.3 mg/kg/day, po starting from day 1 of amyloid beta (1 to 42) oligomer treatment and measured on day 7 by Y-maze | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Novel sarsasapogenin-triazolyl hybrids as potential anti-Alzheimer's agents: Design, synthesis and biological evaluation. |
| AID638225 | Inhibition of electric eel AChE using acetylcholine as substrate measured every sec for 2 mins by Ellman's method | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
| AChE inhibitor: a regio- and stereo-selective 1,3-dipolar cycloaddition for the synthesis of novel substituted 5,6-dimethoxy spiro[5.3']-oxindole-spiro-[6.3″]-2,3-dihydro-1H-inden-1″-one-7-(substituted aryl)-tetrahydro-1H-pyrrolo[1,2-c][1,3]thiazole. |
| AID1220474 | Cmax in 30 months-old Lister Hooded rat at 3 mg/kg, po | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID1220457 | Volume of distribution in 7 months-old Lister Hooded rat at 1 mg/kg, iv infusion for 1 hr | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID1220469 | Volume of distribution in 30 months-old Lister Hooded rat at 1 mg/kg, iv infusion for 1 hr | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID1220486 | Volume of distribution in human at 2 mg, po single dose | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID1220472 | Dose normalized AUC (0 to t) in 30 months-old Lister Hooded rat at 1 mg/kg, iv infusion for 1 hr | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID1220466 | Oral bioavailability in 7 months-old Lister Hooded rat at 3 mg/kg | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID1357831 | Cognitive enhancing effect in Kunming mouse model of amyloid beta (1 to 42) oligomer-induced memory impairment assessed as reduction in spontaneous alternation behaviors at 1.3 mg/kg/day, po starting from day 1 of amyloid beta (1 to 42) oligomer treatment | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Novel sarsasapogenin-triazolyl hybrids as potential anti-Alzheimer's agents: Design, synthesis and biological evaluation. |
| AID603289 | Inhibition of electric eel AChE by modified Ellman method | 2011 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 21, Issue:13
| Synthesis and discovery of novel hexacyclic cage compounds as inhibitors of acetylcholinesterase. |
| AID1730631 | Reversal of scopolamine-induced memory impairment in Kunming mouse assessed as decrease in number of errors at 10 mg/kg, po treated 1 hr before training trial measured 24 hrs after training trial by step-down passive avoidance test | 2021 | European journal of medicinal chemistry, Mar-05, Volume: 213 | Design, synthesis, and biological evaluation of novel xanthone-alkylbenzylamine hybrids as multifunctional agents for the treatment of Alzheimer's disease. |
| AID1220473 | Dose normalized AUC (0 to infinity) in 30 months-old Lister Hooded rat at 1 mg/kg, iv infusion for 1 hr | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID1220470 | Half life in 30 months-old Lister Hooded rat at 1 mg/kg, iv infusion for 1 hr | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID1357836 | Cognitive enhancing effect in Kunming mouse model of amyloid beta (1 to 42) oligomer-induced memory impairment assessed as induction of fewer entries into dark compartment at 1.3 mg/kg, po starting from day 1 of amyloid beta (1 to 42) oligomer treatment a | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Novel sarsasapogenin-triazolyl hybrids as potential anti-Alzheimer's agents: Design, synthesis and biological evaluation. |
| AID1126594 | Inhibition of electric eel AChE type VI-S using acetylthiocholine iodide as substrate preincubated with enzyme for 10 mins prior to substrate challenge for 15 mins by Ellman's method | 2014 | European journal of medicinal chemistry, May-06, Volume: 78 | Novel structural hybrids of pyrazolobenzothiazines with benzimidazoles as cholinesterase inhibitors. |
| AID1220512 | Cmax in 7 months-old Lister Hooded rat at 1 mg/kg, iv infusion for 1 hr | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID1515413 | In vivo inhibition of BuChE in Swiss mouse liver at 3 to 6 mg/kg, iv by Ellman's assay | 2019 | Bioorganic & medicinal chemistry, 01-15, Volume: 27, Issue:2
| In silico, NMR and pharmacological evaluation of an hydroxyoxindole cholinesterase inhibitor. |
| AID1220478 | Oral bioavailability in 30 months-old Lister Hooded rat at 3 mg/kg | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID739639 | Inhibition of electric eel AChE after 30 mins by Ellman's method | 2013 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7
| A one-pot domino synthesis and discovery of highly functionalized dihydrobenzo[b]thiophenes as AChE inhibitors. |
| AID1220476 | Dose normalized AUC (0 to t) in 30 months-old Lister Hooded rat at 3 mg/kg, po | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID1220463 | Tmax in 7 months-old Lister Hooded rat at 3 mg/kg, po | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID592640 | Inhibition of human AChE incubated with compounf for 5 mins before addition of substrate acetylthiocholine iodide by Ellman's method | 2011 | Bioorganic & medicinal chemistry, Apr-01, Volume: 19, Issue:7
| Design, synthesis and structure-activity relationship (SAR) studies of 2,4-disubstituted pyrimidine derivatives: dual activity as cholinesterase and Aβ-aggregation inhibitors. |
| AID1220464 | Dose normalized AUC (0 to t) in 7 months-old Lister Hooded rat at 3 mg/kg, po | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID753136 | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 10 mins prior to substrate addition by Ellman's method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Synthesis and evaluation of 4-substituted coumarins as novel acetylcholinesterase inhibitors. |
| AID1220465 | Dose normalized AUC (0 to infinity) in 7 months-old Lister Hooded rat at 3 mg/kg, po | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID31781 | Inhibitory activity against acetylcholinesterase | 1995 | Journal of medicinal chemistry, Nov-24, Volume: 38, Issue:24
| Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds. |
| AID1357833 | Memory enhancing effect in Kunming mouse model of amyloid beta (1 to 42) oligomer-induced memory impairment assessed as increase in preferential index in retention session of 1 hr at 1.3 mg/kg/day, po starting from day 1 of amyloid beta (1 to 42) oligomer | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Novel sarsasapogenin-triazolyl hybrids as potential anti-Alzheimer's agents: Design, synthesis and biological evaluation. |
| AID621448 | Inhibition of human AChE by Ellman's assay | 2011 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19
| Development of 2-substituted-N-(naphth-1-ylmethyl) and N-benzhydrylpyrimidin-4-amines as dual cholinesterase and Aβ-aggregation inhibitors: Synthesis and biological evaluation. |
| AID621450 | Selectivity index, ratio of IC50 for human AChE to IC50 for equine BuChE | 2011 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19
| Development of 2-substituted-N-(naphth-1-ylmethyl) and N-benzhydrylpyrimidin-4-amines as dual cholinesterase and Aβ-aggregation inhibitors: Synthesis and biological evaluation. |
| AID1220494 | Inhibition of acetylcholinesterase activity in 7 months-old Lister Hooded rat plasma at 3 mg/kg, po after 1 hr treatment | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID1220498 | Inhibition of cholinesterase activity in 30 months-old Lister Hooded rat plasma assessed as percent enhancement of inhibition at 3 mg/kg, po after 1 hr treatment | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID404848 | Inhibition of human recombinant AChE-induced amyloid beta 1-40 aggregation at 100 uM | 2008 | Journal of medicinal chemistry, Jun-26, Volume: 51, Issue:12
| Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation. |
| AID1357829 | Neuroprotective activity amyloid beta (1 to 42) oligomer-induced memory impaired Kunming mouse assessed as reduction in apoptotic cells in CA1 and CA3 hipocampal neurons at 1.3 mg/kg, po starting from day 1 of amyloid beta (1 to 42) oligomer treatment and | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Novel sarsasapogenin-triazolyl hybrids as potential anti-Alzheimer's agents: Design, synthesis and biological evaluation. |
| AID592641 | Inhibition of equine BChE incubated with compounf for 5 mins before addition of substrate S-butyrylthiocholine iodide by Ellman's method | 2011 | Bioorganic & medicinal chemistry, Apr-01, Volume: 19, Issue:7
| Design, synthesis and structure-activity relationship (SAR) studies of 2,4-disubstituted pyrimidine derivatives: dual activity as cholinesterase and Aβ-aggregation inhibitors. |
| AID757776 | Inhibition of electric eel AChE after 30 mins by Ellman's method | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | An atom economic synthesis and AChE inhibitory activity of novel dispiro 7-aryltetrahydro-1H-pyrrolo[1,2-c][1,3]thiazole and 4-aryloctahydroindolizine N-methylpiperidin-4-one hybrid heterocycles. |
| AID1220460 | Dose normalized AUC (0 to t) in 7 months-old Lister Hooded rat at 1 mg/kg, iv infusion for 1 hr | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID1220458 | Half life in 7 months-old Lister Hooded rat at 1 mg/kg, iv infusion for 1 hr | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID1220467 | Cmax in 30 months-old Lister Hooded rat at 1 mg/kg, iv infusion for 1 hr | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID1220461 | Dose normalized AUC (0 to infinity) in 7 months-old Lister Hooded rat at 1 mg/kg, iv infusion for 1 hr | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID719015 | Selectivity ratio of IC50 for equine serum BuChE to IC50 for electric eel AChE | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24
| Novel coumarin derivatives bearing N-benzyl pyridinium moiety: potent and dual binding site acetylcholinesterase inhibitors. |
| AID404842 | Inhibition of bovine erythrocyte AChE by Ellman's assay | 2008 | Journal of medicinal chemistry, Jun-26, Volume: 51, Issue:12
| Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation. |
| AID1497848 | Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate pretreated for 15 mins followed by substrate addition measured for 6 mins by Ellman's method | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12
| Design, synthesis and biological evaluation of benzofuran appended benzothiazepine derivatives as inhibitors of butyrylcholinesterase and antimicrobial agents. |
| AID1467548 | Inhibition of AChE (unknown origin) using acetylcholine as substrate preincubated for 15 mins followed by substrate addition measured every minute by spectrophotometric analysis | 2017 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
| One-pot microwave assisted stereoselective synthesis of novel dihydro-2'H-spiro[indene-2,1'-pyrrolo-[3,4-c]pyrrole]-tetraones and evaluation of their antimycobacterial activity and inhibition of AChE. |
| AID1220491 | Drug excretion in human feces at 2 mg, po single dose | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID1515412 | In vivo inhibition of AChE in Swiss mouse brain assessed as enzyme activity at 3 mg/kg, iv by Ellman's assay | 2019 | Bioorganic & medicinal chemistry, 01-15, Volume: 27, Issue:2
| In silico, NMR and pharmacological evaluation of an hydroxyoxindole cholinesterase inhibitor. |
| AID1357837 | Neuroprotective activity in Kunming mouse model of amyloid beta (1 to 42) oligomer-induced memory impairment assessed as reduction in neural degeneration in CA1 region at 1.3 mg/kg, po starting from day 1 of amyloid beta (1 to 42) oligomer treatment and m | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Novel sarsasapogenin-triazolyl hybrids as potential anti-Alzheimer's agents: Design, synthesis and biological evaluation. |
| AID1220489 | Drug excretion in human urine at 2 mg, po single dose | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID1472432 | Reversal of scopolamine-induced memory impairment in C57BL/6J mouse assessed as decrease in traveled distance to reach the escape platform at 10 mg/kg, ip administered 60 mins prior to test post scopolamine challenge measured on day 7 by Morris water maze | 2018 | Journal of medicinal chemistry, 01-11, Volume: 61, Issue:1
| The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity. |
| AID621452 | Inhibition of amyloid beta (1 to 40) self-aggregation at 100 uM after 24 hrs by thioflavin T-based fluorometric assay | 2011 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19
| Development of 2-substituted-N-(naphth-1-ylmethyl) and N-benzhydrylpyrimidin-4-amines as dual cholinesterase and Aβ-aggregation inhibitors: Synthesis and biological evaluation. |
| AID404434 | Inhibition of Torpedo californica AChE | 2008 | Journal of medicinal chemistry, Jun-12, Volume: 51, Issue:11
| Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors. |
| AID1220487 | Clearance in human at 2 mg, po single dose | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID1220485 | Half life in human at 2 mg, po single dose | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID1220459 | Mean residence time in 7 months-old Lister Hooded rat at 1 mg/kg, iv infusion for 1 hr | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID1730630 | Reversal of scopolamine-induced memory impairment in Kunming mouse assessed as increase in latency time at 10 mg/kg, po treated 1 hr before training trial measured 24 hrs after training trial by step-down passive avoidance test | 2021 | European journal of medicinal chemistry, Mar-05, Volume: 213 | Design, synthesis, and biological evaluation of novel xanthone-alkylbenzylamine hybrids as multifunctional agents for the treatment of Alzheimer's disease. |
| AID1220502 | Drug uptake in 30 months-old Lister Hooded rat blood at 3 mg/kg, po after 1 hr treatment | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID719018 | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate by Ellman's method | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24
| Novel coumarin derivatives bearing N-benzyl pyridinium moiety: potent and dual binding site acetylcholinesterase inhibitors. |
| AID1515416 | Inhibition of AChE in Swiss mouse liver homogenate using acetylthiocholine iodide as substrate by Ellman's assay | 2019 | Bioorganic & medicinal chemistry, 01-15, Volume: 27, Issue:2
| In silico, NMR and pharmacological evaluation of an hydroxyoxindole cholinesterase inhibitor. |
| AID1220490 | Drug excretion in human urine assessed as unchanged drug level at 2 mg, po single dose | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID1472429 | Reversal of scopolamine-induced memory loss in C57BL/6J mouse assessed as decrease in escape latency time at 10 mg/kg, ip administered 60 mins prior to test post scopolamine-challenge measured on day 7 by Morris water maze test | 2018 | Journal of medicinal chemistry, 01-11, Volume: 61, Issue:1
| The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity. |
| AID1220477 | Dose normalized AUC (0 to infinity) in 30 months-old Lister Hooded rat at 3 mg/kg, po | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID1220481 | Inhibition of acetylcholinesterase activity in 7 months-old Lister Hooded rat brain at 3 mg/kg, po after 1 hr treatment | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID1220471 | Mean residence time in 30 months-old Lister Hooded rat at 1 mg/kg, iv infusion for 1 hr | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID501762 | Inhibition of electric eel AChE by Ellman's method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17
| Design, synthesis and anticholinesterase activity of a novel series of 1-benzyl-4-((6-alkoxy-3-oxobenzofuran-2(3H)-ylidene) methyl) pyridinium derivatives. |
| AID1220483 | Plasma protein binding in human at 2 mg, po single dose | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID1515411 | Inhibition of BuChE in Swiss mouse liver homogenate by Ellman's assay | 2019 | Bioorganic & medicinal chemistry, 01-15, Volume: 27, Issue:2
| In silico, NMR and pharmacological evaluation of an hydroxyoxindole cholinesterase inhibitor. |
| AID1220500 | Drug uptake in 7 months-old Lister Hooded rat assessed as corrected brain concentration at 3 mg/kg, po after 1 hr treatment | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID753135 | Inhibition of equine serum BChE using butylthiocholine iodide as substrate preincubated for 10 mins prior to substrate addition by Ellman's method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Synthesis and evaluation of 4-substituted coumarins as novel acetylcholinesterase inhibitors. |
| AID1220462 | Cmax in 7 months-old Lister Hooded rat at 3 mg/kg, po | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID1220468 | Blood clearance in 30 months-old Lister Hooded rat at 1 mg/kg, iv infusion for 1 hr | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID1220492 | Inhibition of cholinesterase activity in F344 rat brain at 2.5 mg/kg, po after 1 hr treatment | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID229262 | Ratio of IC50 for BuChE to AChE | 1995 | Journal of medicinal chemistry, Nov-24, Volume: 38, Issue:24
| Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds. |
| AID1472436 | Reversal of scopolamine-induced hyperlocomotion in C57BL/6J mouse assessed as speed of swimming at 10 mg/kg, ip administered 60 mins prior to test post scopolamine challenge measured on day 7 by Morris water maze test (Rvb = 0.20 meter/s) | 2018 | Journal of medicinal chemistry, 01-11, Volume: 61, Issue:1
| The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity. |
| AID1220503 | Drug uptake in 30 months-old Lister Hooded rat assessed as corrected brain concentration at 3 mg/kg, po after 1 hr treatment | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID1220484 | Tmax in human at 2 mg, po single dose | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID1357838 | Neuroprotective activity in Kunming mouse model of amyloid beta (1 to 42) oligomer-induced memory impairment assessed as reduction in neuronal degeneration by measuring clear and intact neurons in CA1 and CA3 region at 1.3 mg/kg, po starting from day 1 of | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Novel sarsasapogenin-triazolyl hybrids as potential anti-Alzheimer's agents: Design, synthesis and biological evaluation. |
| AID404844 | Inhibition of human serum BChE by Ellman's assay | 2008 | Journal of medicinal chemistry, Jun-26, Volume: 51, Issue:12
| Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation. |
| AID1220475 | Tmax in 30 months-old Lister Hooded rat at 3 mg/kg, po | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID719017 | Inhibition of equine serum BuChE using acetylthiocholine iodide as substrate by Ellman's method | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24
| Novel coumarin derivatives bearing N-benzyl pyridinium moiety: potent and dual binding site acetylcholinesterase inhibitors. |
| AID1220504 | Ratio of brain to blood in 30 months-old Lister Hooded rat blood at 3 mg/kg, po after 1 hr treatment | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3
| Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. |
| AID1357839 | Neuroprotective activity in Kunming mouse model of amyloid beta (1 to 42) oligomer-induced memory impairment assessed as reduction in neuronal degeneration by measuring reduction in degenerative changes in nucleus of CA1 and CA3 region at 1.3 mg/kg, po st | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Novel sarsasapogenin-triazolyl hybrids as potential anti-Alzheimer's agents: Design, synthesis and biological evaluation. |
| AID1126596 | Inhibition of BuChE in equine serum using butyrylthiocholine chloride as substrate preincubated with enzyme for 10 mins prior to substrate challenge for 15 mins by Ellman's method | 2014 | European journal of medicinal chemistry, May-06, Volume: 78 | Novel structural hybrids of pyrazolobenzothiazines with benzimidazoles as cholinesterase inhibitors. |
| AID1173565 | Inhibition of AChE (unknown origin) assessed as inhibition of acetylcholine hydrolysis preincubated for 15 mins by Ellman method | 2014 | Journal of natural products, Dec-26, Volume: 77, Issue:12
| Anithiactins A-C, modified 2-phenylthiazoles from a mudflat-derived Streptomyces sp. |
| AID1357835 | Cognitive enhancing effect in Kunming mouse model of amyloid beta (1 to 42) oligomer-induced memory impairment assessed as longer escape latency at 1.3 mg/kg, po starting from day 1 of amyloid beta (1 to 42) oligomer treatment and measured on day 7 by pas | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Novel sarsasapogenin-triazolyl hybrids as potential anti-Alzheimer's agents: Design, synthesis and biological evaluation. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |