psychotropic drug

A loosely defined grouping of drugs that have effects on psychological function.

ChEBI ID: 35471

Members (16)

Member	Definition	Class
1-(3-trifluoromethylphenyl)piperazine	A N-arylpiperazine that is piperazine substituted by a 3-(trifluoromethyl)phenyl group at position 1. A serotonergic agonist used as a recreational drug.	1-(3-(trifluoromethyl)phenyl)piperazine
1-benzylpiperazine	A tertiary amino compound that is piperazine substituted by a benzyl group at position 1. It is a serotonergic agonist used as a recreational drug.	1-benzylpiperazine
caffeine	A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee.	caffeine
cathinone	The S stereoisomer of 2-aminopropiophenone.	cathinone
cytidine diphosphate choline	A member of the class of phosphocholines that is the chloine ester of CDP. It is an intermediate obtained in the biosynthetic pathway of structural phospholipids in cell membranes.	CDP-choline
cytidine diphosphate choline	A member of the class of phosphocholines that is the chloine ester of CDP. It is an intermediate obtained in the biosynthetic pathway of structural phospholipids in cell membranes.	CDP-choline
methamphetamine	A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent.	methamphetamine
muscimol	A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.	muscimol
nicotine	A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.	(S)-nicotine
noribogaine	An organic heteropentacyclic compound that is ibogamine in which the indole hydrogen para to the indole nitrogen has been replaced by a hydroxy group. It is the primary (and long-lived) metabolite of ibogaine, the psychoactive indole alkaloid found in the African rainforest shrub Tabernanthe iboga.	noribogaine
norpseudoephedrine	An amphetamine that is propylbenzene substituted by a hydroxy group at position 1 and by an amino group at position 2 (the 1S,2S-stereoisomer).	cathine
phencyclidine	A member of the class of piperidines that is piperidine in which the nitrogen is substituted with a 1-phenylcyclohexyl group. Formerly used as an anaesthetic agent, it exhibits both hallucinogenic and neurotoxic effects.	phencyclidine
risperidone	A member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2.	risperidone
spiperone	An azaspiro compound that is 1,3,8-triazaspiro[4.5]decane which is substituted at positions 1, 4, and 8 by phenyl, oxo, and 4-(p-fluorophenyl)-4-oxobutyl groups, respectively.	spiperone
valproic acid	A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.	valproic acid
ziprasidone	A piperazine compound having 1,2-benzothiazol-3-yl- and 2-(6-chloro-1,3-dihydro-2-oxindol-5-yl)ethyl substituents attached to the nitrogen atoms.	ziprasidone

Research

Studies (116,151)

Timeframe	Studies, Drugs with This Role(%)	All Drugs %
pre-1990	30,395 (26.17)	18.7374
1990's	18,766 (16.16)	18.2507
2000's	26,156 (22.52)	29.6817
2010's	29,274 (25.20)	24.3611
2020's	11,560 (9.95)	2.80

Study Types

Publication Type	Studies, Drugs with this Role (%)	All Drugs (%)
Trials	8,669 (6.92%)	5.53%
Reviews	9,741 (7.78%)	6.00%
Case Studies	6,273 (5.01%)	4.05%
Observational	323 (0.26%)	0.25%
Other	100,225 (80.03%)	84.16%

Protein Targets (427)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
67.9K protein	Vaccinia virus	Potency	33.9972	1	2
acetylcholinesterase	Homo sapiens (human)	Potency	14.3740	2	4
activating transcription factor 6	Homo sapiens (human)	Potency	9.5205	2	2
aldehyde dehydrogenase 1 family, member A1	Homo sapiens (human)	Potency	30.9135	1	4
AR protein	Homo sapiens (human)	Potency	25.1797	10	28
aryl hydrocarbon receptor	Homo sapiens (human)	Potency	33.5761	2	3
arylsulfatase A	Homo sapiens (human)	Potency	11.7440	1	4
ATAD5 protein, partial	Homo sapiens (human)	Potency	16.7916	2	2
Ataxin-2	Homo sapiens (human)	Potency	47.5964	1	2
ATP-dependent phosphofructokinase	Trypanosoma brucei brucei TREU927	Potency	21.6592	1	2
ATPase family AAA domain-containing protein 5	Homo sapiens (human)	Potency	40.5987	2	3
atrial natriuretic peptide receptor 1 precursor	Homo sapiens (human)	Potency	4.7755	1	1
bromodomain adjacent to zinc finger domain 2B	Homo sapiens (human)	Potency	50.1187	1	1
Cellular tumor antigen p53	Homo sapiens (human)	Potency	28.3644	1	4
cellular tumor antigen p53 isoform a	Homo sapiens (human)	Potency	4.0871	2	2
Chain A, 2-oxoglutarate Oxygenase	Homo sapiens (human)	Potency	22.3872	1	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	Homo sapiens (human)	Potency	6.3096	1	1
Chain A, Beta-lactamase	Escherichia coli K-12	Potency	17.7828	1	1
Chain A, Ferritin light chain	Equus caballus (horse)	Potency	0.2512	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	Homo sapiens (human)	Potency	89.1251	1	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	Homo sapiens (human)	Potency	44.6684	1	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	Homo sapiens (human)	Potency	2.5119	1	1
chromobox protein homolog 1	Homo sapiens (human)	Potency	56.2565	1	3
cytochrome P450 2C19 precursor	Homo sapiens (human)	Potency	15.9017	1	3
cytochrome P450 2C9, partial	Homo sapiens (human)	Potency	12.3018	1	1
cytochrome P450 2D6	Homo sapiens (human)	Potency	4.2782	1	3
cytochrome P450 2D6 isoform 1	Homo sapiens (human)	Potency	3.2405	1	5
cytochrome P450 3A4 isoform 1	Homo sapiens (human)	Potency	14.5500	2	4
cytochrome P450 family 3 subfamily A polypeptide 4	Homo sapiens (human)	Potency	17.3202	2	3
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	Homo sapiens (human)	Potency	29.6253	1	4
D(1A) dopamine receptor	Homo sapiens (human)	Potency	4.7159	3	3
Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)	Potency	15.8489	1	1
DNA polymerase beta	Homo sapiens (human)	Potency	79.4328	1	1
DNA polymerase kappa isoform 1	Homo sapiens (human)	Potency	11.9173	1	1
estrogen nuclear receptor alpha	Homo sapiens (human)	Potency	30.0185	9	29
estrogen-related nuclear receptor alpha	Homo sapiens (human)	Potency	28.1821	6	16
euchromatic histone-lysine N-methyltransferase 2	Homo sapiens (human)	Potency	13.0982	1	5
EWS/FLI fusion protein	Homo sapiens (human)	Potency	24.9119	4	5
farnesoid X nuclear receptor	Homo sapiens (human)	Potency	30.4248	2	5
Fumarate hydratase	Homo sapiens (human)	Potency	22.3872	1	1
G	Vesicular stomatitis virus	Potency	12.3018	1	1
GABA theta subunit	Rattus norvegicus (Norway rat)	Potency	14.5500	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)	Potency	14.5500	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	Rattus norvegicus (Norway rat)	Potency	14.5500	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	Rattus norvegicus (Norway rat)	Potency	14.5500	1	2
Gamma-aminobutyric acid receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Potency	14.5500	1	2
Gamma-aminobutyric acid receptor subunit alpha-5	Rattus norvegicus (Norway rat)	Potency	14.5500	1	2
Gamma-aminobutyric acid receptor subunit alpha-6	Rattus norvegicus (Norway rat)	Potency	14.5500	1	2
Gamma-aminobutyric acid receptor subunit beta-1	Rattus norvegicus (Norway rat)	Potency	14.5500	1	2
Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)	Potency	14.5500	1	2
Gamma-aminobutyric acid receptor subunit beta-3	Rattus norvegicus (Norway rat)	Potency	14.5500	1	2
Gamma-aminobutyric acid receptor subunit delta	Rattus norvegicus (Norway rat)	Potency	14.5500	1	2
Gamma-aminobutyric acid receptor subunit epsilon	Rattus norvegicus (Norway rat)	Potency	14.5500	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	Rattus norvegicus (Norway rat)	Potency	14.5500	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)	Potency	14.5500	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	Rattus norvegicus (Norway rat)	Potency	14.5500	1	2
Gamma-aminobutyric acid receptor subunit pi	Rattus norvegicus (Norway rat)	Potency	14.5500	1	2
geminin	Homo sapiens (human)	Potency	3.5942	2	4
GLI family zinc finger 3	Homo sapiens (human)	Potency	25.4571	2	8
glp-1 receptor, partial	Homo sapiens (human)	Potency	10.0000	1	1
GLS protein	Homo sapiens (human)	Potency	35.9957	2	3
glucocorticoid receptor [Homo sapiens]	Homo sapiens (human)	Potency	141.6999	5	7
Glutamate receptor 2	Rattus norvegicus (Norway rat)	Potency	28.2309	1	3
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	Homo sapiens (human)	Potency	16.0341	2	3
heat shock protein beta-1	Homo sapiens (human)	Potency	33.4889	2	2
Histamine H2 receptor	Cavia porcellus (domestic guinea pig)	Potency	8.9716	1	4
histone acetyltransferase KAT2A isoform 1	Homo sapiens (human)	Potency	0.8554	1	2
HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)	Potency	12.3018	1	1
hypoxia-inducible factor 1 alpha subunit	Homo sapiens (human)	Potency	13.5137	1	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	Homo sapiens (human)	Potency	11.0959	2	8
Inositol hexakisphosphate kinase 1	Homo sapiens (human)	Potency	12.3018	1	2
Inositol monophosphatase 1	Rattus norvegicus (Norway rat)	Potency	28.1838	1	1
Integrin alpha-IIb	Homo sapiens (human)	Potency	5.0119	1	1
Integrin beta-3	Homo sapiens (human)	Potency	5.0119	1	1
Interferon beta	Homo sapiens (human)	Potency	12.3018	1	1
interleukin 8	Homo sapiens (human)	Potency	47.3079	1	1
lamin isoform A-delta10	Homo sapiens (human)	Potency	15.1652	1	2
lethal factor (plasmid)	Bacillus anthracis str. A2012	Potency	3.4007	1	3
Luciferase	Photinus pyralis (common eastern firefly)	Potency	36.1254	1	1
Microtubule-associated protein tau	Homo sapiens (human)	Potency	20.6206	2	4
mitogen-activated protein kinase 1	Homo sapiens (human)	Potency	3.1623	1	1
muscarinic acetylcholine receptor M1	Rattus norvegicus (Norway rat)	Potency	12.0232	2	6
NPC intracellular cholesterol transporter 1 precursor	Homo sapiens (human)	Potency	94.5937	1	2
nuclear factor erythroid 2-related factor 2 isoform 1	Homo sapiens (human)	Potency	193.9034	3	8
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	Homo sapiens (human)	Potency	25.3735	1	2
Nuclear receptor ROR-gamma	Homo sapiens (human)	Potency	50.1579	1	2
nuclear receptor ROR-gamma isoform 1	Mus musculus (house mouse)	Potency	10.1578	2	2
nuclear receptor subfamily 1, group I, member 3	Homo sapiens (human)	Potency	32.6602	2	7
peripheral myelin protein 22	Rattus norvegicus (Norway rat)	Potency	32.1968	1	1
peripheral myelin protein 22 isoform 1	Homo sapiens (human)	Potency	75.6863	1	1
peroxisome proliferator activated receptor gamma	Homo sapiens (human)	Potency	794.3280	1	1
peroxisome proliferator-activated receptor delta	Homo sapiens (human)	Potency	22.6856	2	2
phosphopantetheinyl transferase	Bacillus subtilis	Potency	64.4679	1	2
polyprotein	Zika virus	Potency	22.3872	1	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	Homo sapiens (human)	Potency	8.9716	1	2
potassium voltage-gated channel subfamily H member 2 isoform d	Homo sapiens (human)	Potency	9.2602	1	5
pregnane X nuclear receptor	Homo sapiens (human)	Potency	7.2048	1	3
pregnane X receptor	Rattus norvegicus (Norway rat)	Potency	501.1870	1	1
progesterone receptor	Homo sapiens (human)	Potency	31.6704	2	2
RAR-related orphan receptor gamma	Mus musculus (house mouse)	Potency	20.8023	2	5
ras-related protein Rab-9A	Homo sapiens (human)	Potency	48.2333	1	2
regulator of G-protein signaling 4	Homo sapiens (human)	Potency	1.0618	1	3
retinoic acid nuclear receptor alpha variant 1	Homo sapiens (human)	Potency	42.5044	3	9
retinoid X nuclear receptor alpha	Homo sapiens (human)	Potency	13.0162	2	5
Smad3	Homo sapiens (human)	Potency	6.4304	1	4
Spike glycoprotein	Severe acute respiratory syndrome-related coronavirus	Potency	39.8107	1	1
survival motor neuron protein isoform d	Homo sapiens (human)	Potency	1.2589	1	1
TAR DNA-binding protein 43	Homo sapiens (human)	Potency	39.8107	1	1
TDP1 protein	Homo sapiens (human)	Potency	21.6988	2	10
thioredoxin glutathione reductase	Schistosoma mansoni	Potency	31.6228	1	1
thioredoxin reductase	Rattus norvegicus (Norway rat)	Potency	20.4188	1	3
thyroid hormone receptor beta isoform 2	Rattus norvegicus (Norway rat)	Potency	20.8855	2	9
thyroid hormone receptor beta isoform a	Homo sapiens (human)	Potency	0.0568	1	2
thyroid stimulating hormone receptor	Homo sapiens (human)	Potency	17.8014	5	8
thyrotropin-releasing hormone receptor	Homo sapiens (human)	Potency	9.9878	2	2
transcriptional regulator ERG isoform 3	Homo sapiens (human)	Potency	3.9811	1	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	Homo sapiens (human)	Potency	15.8489	1	1
v-jun sarcoma virus 17 oncogene homolog (avian)	Homo sapiens (human)	Potency	25.8766	2	4
Voltage-dependent calcium channel gamma-2 subunit	Mus musculus (house mouse)	Potency	28.2309	1	3

Inhibition Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
3-hydroxy-3-methylglutaryl-coenzyme A reductase	Rattus norvegicus (Norway rat)	Ki	0.0230	1	2
5-hydroxytryptamine receptor 1A	Mus musculus (house mouse)	IC50	0.4300	1	1
5-hydroxytryptamine receptor 1A	Rattus norvegicus (Norway rat)	IC50	0.4597	2	3
5-hydroxytryptamine receptor 1A	Homo sapiens (human)	Ki	0.1865	10	14
5-hydroxytryptamine receptor 1A	Rattus norvegicus (Norway rat)	Ki	0.2073	15	16
5-hydroxytryptamine receptor 1B	Oryctolagus cuniculus (rabbit)	IC50	100.0000	1	1
5-hydroxytryptamine receptor 1B	Rattus norvegicus (Norway rat)	IC50	0.2923	3	3
5-hydroxytryptamine receptor 1B	Rattus norvegicus (Norway rat)	Ki	0.7842	5	7
5-hydroxytryptamine receptor 1D	Homo sapiens (human)	IC50	0.6100	1	1
5-hydroxytryptamine receptor 1D	Rattus norvegicus (Norway rat)	Ki	0.0666	2	3
5-hydroxytryptamine receptor 1E	Homo sapiens (human)	IC50	50.0000	1	1
5-hydroxytryptamine receptor 1F	Rattus norvegicus (Norway rat)	Ki	0.0666	2	3
5-hydroxytryptamine receptor 2A	Homo sapiens (human)	IC50	0.0014	4	5
5-hydroxytryptamine receptor 2A	Mus musculus (house mouse)	IC50	0.0015	1	1
5-hydroxytryptamine receptor 2A	Rattus norvegicus (Norway rat)	IC50	0.1664	7	7
5-hydroxytryptamine receptor 2A	Homo sapiens (human)	Ki	0.0006	22	27
5-hydroxytryptamine receptor 2A	Rattus norvegicus (Norway rat)	Ki	0.4505	20	23
5-hydroxytryptamine receptor 2B	Homo sapiens (human)	IC50	0.0230	1	1
5-hydroxytryptamine receptor 2B	Mus musculus (house mouse)	IC50	0.0015	1	1
5-hydroxytryptamine receptor 2B	Rattus norvegicus (Norway rat)	IC50	0.1162	5	5
5-hydroxytryptamine receptor 2B	Homo sapiens (human)	Ki	0.0122	2	3
5-hydroxytryptamine receptor 2B	Rattus norvegicus (Norway rat)	Ki	1.0356	9	10
5-hydroxytryptamine receptor 2C	Homo sapiens (human)	IC50	0.0263	7	7
5-hydroxytryptamine receptor 2C	Rattus norvegicus (Norway rat)	IC50	0.1162	5	5
5-hydroxytryptamine receptor 2C	Homo sapiens (human)	Ki	0.0701	18	23
5-hydroxytryptamine receptor 2C	Rattus norvegicus (Norway rat)	Ki	1.4395	15	16
5-hydroxytryptamine receptor 2C	Mus musculus (house mouse)	IC50	0.0015	1	1
5-hydroxytryptamine receptor 3A	Homo sapiens (human)	Ki	29.0356	3	5
5-hydroxytryptamine receptor 3B	Homo sapiens (human)	Ki	29.0356	3	5
5-hydroxytryptamine receptor 3C	Homo sapiens (human)	Ki	29.0356	3	5
5-hydroxytryptamine receptor 3D	Homo sapiens (human)	Ki	29.0356	3	5
5-hydroxytryptamine receptor 3E	Homo sapiens (human)	Ki	29.0356	3	5
5-hydroxytryptamine receptor 4	Cavia porcellus (domestic guinea pig)	IC50	0.0150	1	1
5-hydroxytryptamine receptor 4	Cavia porcellus (domestic guinea pig)	Ki	0.0494	2	2
5-hydroxytryptamine receptor 4	Rattus norvegicus (Norway rat)	IC50	35.0000	1	1
5-hydroxytryptamine receptor 5A	Homo sapiens (human)	Ki	63.0000	1	1
5-hydroxytryptamine receptor 6	Homo sapiens (human)	Ki	0.8780	12	15
5-hydroxytryptamine receptor 7	Homo sapiens (human)	Ki	0.0429	9	11
5-hydroxytryptamine receptor 7	Mus musculus (house mouse)	Ki	0.0630	1	1
5-hydroxytryptamine receptor 7	Rattus norvegicus (Norway rat)	Ki	0.0184	4	5
Acetylcholine receptor subunit alpha	Homo sapiens (human)	IC50	11.0000	2	2
Acetylcholine receptor subunit alpha	Tetronarce californica (Pacific electric ray)	IC50	0.0025	2	2
Acetylcholine receptor subunit alpha	Homo sapiens (human)	Ki	3.3139	4	4
Acetylcholine receptor subunit alpha	Tetronarce californica (Pacific electric ray)	Ki	8.1350	2	2
Acetylcholine receptor subunit beta	Homo sapiens (human)	IC50	1.0000	1	1
Acetylcholine receptor subunit beta	Tetronarce californica (Pacific electric ray)	IC50	0.0025	2	2
Acetylcholine receptor subunit beta	Homo sapiens (human)	Ki	3.3139	4	4
Acetylcholine receptor subunit beta	Tetronarce californica (Pacific electric ray)	Ki	8.1350	2	2
Acetylcholine receptor subunit beta-like 2	Drosophila melanogaster (fruit fly)	IC50	4.0000	1	1
Acetylcholine receptor subunit beta-like 2	Drosophila melanogaster (fruit fly)	Ki	2.7000	1	1
Acetylcholine receptor subunit delta	Homo sapiens (human)	IC50	1.0000	1	1
Acetylcholine receptor subunit delta	Tetronarce californica (Pacific electric ray)	IC50	0.0025	2	2
Acetylcholine receptor subunit delta	Homo sapiens (human)	Ki	3.3139	4	4
Acetylcholine receptor subunit delta	Tetronarce californica (Pacific electric ray)	Ki	8.1350	2	2
Acetylcholine receptor subunit gamma	Homo sapiens (human)	IC50	1.0000	1	1
Acetylcholine receptor subunit gamma	Tetronarce californica (Pacific electric ray)	IC50	0.0025	2	2
Acetylcholine receptor subunit gamma	Homo sapiens (human)	Ki	3.3139	4	4
Acetylcholine receptor subunit gamma	Tetronarce californica (Pacific electric ray)	Ki	8.1350	2	2
Acetylcholine-binding protein	Lymnaea stagnalis (great pond snail)	Ki	0.2236	7	8
Acetylcholinesterase	Homo sapiens (human)	IC50	7.2500	1	1
Adenosine receptor A1	Rattus norvegicus (Norway rat)	IC50	113.5000	2	2
Adenosine receptor A1	Cavia porcellus (domestic guinea pig)	Ki	100.0000	5	5
Adenosine receptor A1	Homo sapiens (human)	Ki	35.4333	15	15
Adenosine receptor A1	Rattus norvegicus (Norway rat)	Ki	37.5909	30	33
Adenosine receptor A2a	Homo sapiens (human)	IC50	20.4720	1	1
Adenosine receptor A2a	Rattus norvegicus (Norway rat)	IC50	63.0000	1	5
Adenosine receptor A2a	Cavia porcellus (domestic guinea pig)	Ki	50.0000	3	3
Adenosine receptor A2a	Homo sapiens (human)	Ki	20.5069	21	21
Adenosine receptor A2a	Rattus norvegicus (Norway rat)	Ki	160.9033	25	30
Adenosine receptor A2b	Rattus norvegicus (Norway rat)	IC50	63.0000	1	5
Adenosine receptor A2b	Homo sapiens (human)	Ki	26.7211	19	19
Adenosine receptor A2b	Mus musculus (house mouse)	Ki	23.0000	1	1
Adenosine receptor A2b	Rattus norvegicus (Norway rat)	Ki	35.3050	15	20
Adenosine receptor A3	Homo sapiens (human)	Ki	34.9750	12	12
Adenosine receptor A3	Rattus norvegicus (Norway rat)	Ki	56.6667	6	6
Aldo-keto reductase family 1 member A1	Bos taurus (cattle)	IC50	57.4000	1	1
Aldo-keto reductase family 1 member A1	Homo sapiens (human)	IC50	50.1000	1	1
Aldo-keto reductase family 1 member A1	Rattus norvegicus (Norway rat)	IC50	53.1000	2	2
Aldo-keto reductase family 1 member B1	Rattus norvegicus (Norway rat)	IC50	56.1000	5	5
Aldo-keto reductase family 1 member B7	Rattus norvegicus (Norway rat)	IC50	56.1000	1	1
Alpha-1A adrenergic receptor	Homo sapiens (human)	IC50	0.0106	6	6
Alpha-1A adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	0.0970	1	1
Alpha-1A adrenergic receptor	Bos taurus (cattle)	Ki	0.0135	1	1
Alpha-1A adrenergic receptor	Homo sapiens (human)	Ki	0.0066	7	10
Alpha-1A adrenergic receptor	Rattus norvegicus (Norway rat)	Ki	0.0345	12	17
Alpha-1B adrenergic receptor	Homo sapiens (human)	IC50	0.0110	1	1
Alpha-1B adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	0.0970	1	1
Alpha-1B adrenergic receptor	Homo sapiens (human)	Ki	0.0370	8	11
Alpha-1B adrenergic receptor	Rattus norvegicus (Norway rat)	Ki	0.0455	9	12
Alpha-1D adrenergic receptor	Homo sapiens (human)	IC50	0.0105	2	2
Alpha-1D adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	0.0970	1	1
Alpha-1D adrenergic receptor	Homo sapiens (human)	Ki	0.0067	7	10
Alpha-1D adrenergic receptor	Rattus norvegicus (Norway rat)	Ki	0.0437	10	13
Alpha-2A adrenergic receptor	Homo sapiens (human)	IC50	0.0097	1	1
Alpha-2A adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	0.1514	1	1
Alpha-2A adrenergic receptor	Homo sapiens (human)	Ki	0.1187	5	7
Alpha-2A adrenergic receptor	Rattus norvegicus (Norway rat)	Ki	0.0120	3	3
Alpha-2B adrenergic receptor	Homo sapiens (human)	IC50	0.0260	1	1
Alpha-2B adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	0.1514	1	1
Alpha-2B adrenergic receptor	Homo sapiens (human)	Ki	0.1603	3	5
Alpha-2B adrenergic receptor	Rattus norvegicus (Norway rat)	Ki	0.0054	2	2
Alpha-2C adrenergic receptor	Homo sapiens (human)	IC50	0.0096	1	1
Alpha-2C adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	0.1514	1	1
Alpha-2C adrenergic receptor	Homo sapiens (human)	Ki	0.1323	4	6
Alpha-2C adrenergic receptor	Rattus norvegicus (Norway rat)	Ki	0.0054	2	2
Amine oxidase [flavin-containing] A	Homo sapiens (human)	IC50	50.0000	1	1
Amine oxidase [flavin-containing] B	Homo sapiens (human)	IC50	50.0000	1	1
Amine oxidase [flavin-containing] B	Bos taurus (cattle)	Ki	550.0000	1	1
Amine oxidase [flavin-containing] B	Homo sapiens (human)	Ki	3,700.0000	2	2
Amine oxidase [flavin-containing] B	Rattus norvegicus (Norway rat)	Ki	270.0000	1	1
Angiotensin-converting enzyme	Oryctolagus cuniculus (rabbit)	IC50	4.1901	1	1
Angiotensin-converting enzyme	Oryctolagus cuniculus (rabbit)	Ki	3.4328	1	1
Aspartate aminotransferase, cytoplasmic	Homo sapiens (human)	IC50	5.3900	1	1
ATP-binding cassette sub-family C member 3	Homo sapiens (human)	IC50	133.0000	1	3
Beta-1 adrenergic receptor	Rattus norvegicus (Norway rat)	Ki	22.0000	1	1
Beta-casein	Rattus norvegicus (Norway rat)	Ki	0.0015	1	1
Bile salt export pump	Homo sapiens (human)	IC50	402.0208	4	12
Bile salt export pump	Rattus norvegicus (Norway rat)	IC50	1,000.0000	1	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)	IC50	14,000.0000	1	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	Rattus norvegicus (Norway rat)	IC50	70.0000	1	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	Rattus norvegicus (Norway rat)	IC50	70.0000	1	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	Homo sapiens (human)	IC50	747.0000	1	1
Canalicular multispecific organic anion transporter 1	Homo sapiens (human)	IC50	133.0000	1	3
Carbonic anhydrase 1	Homo sapiens (human)	IC50	28,500.0000	1	2
Carbonic anhydrase 2	Homo sapiens (human)	IC50	28,500.0000	1	2
Caspase-3	Homo sapiens (human)	IC50	100.0000	1	1
Chain A, Chitinase	Clonostachys rosea	Ki	19,700.0000	1	1
Chain A, Glycogen Phosphorylase	Oryctolagus cuniculus (rabbit)	Ki	100.0000	1	1
Chitotriosidase-1	Homo sapiens (human)	IC50	363.0000	1	2
Cholinesterase	Homo sapiens (human)	IC50	50.0000	1	1
Cholinesterase	Mus musculus (house mouse)	Ki	0.5224	2	2
Cocaine esterase	Homo sapiens (human)	Ki	7,900.0000	1	1
Cytochrome P450 1A2	Homo sapiens (human)	IC50	4,100.0000	1	1
Cytochrome P450 2A13	Homo sapiens (human)	Ki	72.0000	1	1
Cytochrome P450 2A5	Mus musculus (house mouse)	IC50	159.9560	1	1
Cytochrome P450 2A6	Homo sapiens (human)	IC50	210.6763	2	3
Cytochrome P450 2A6	Homo sapiens (human)	Ki	2,322.2000	4	4
Cytochrome P450 2B6	Homo sapiens (human)	Ki	10.0000	1	1
Cytochrome P450 2D6	Homo sapiens (human)	IC50	5.2734	1	1
Cytochrome P450 3A4	Homo sapiens (human)	IC50	26.3000	1	1
Cytochrome P450 3A4	Homo sapiens (human)	Ki	0.1425	1	4
D	Mus musculus (house mouse)	IC50	35.0000	1	1
D	Rattus norvegicus (Norway rat)	IC50	0.1514	1	1
D	Rattus norvegicus (Norway rat)	Ki	0.6061	6	7
D-amino-acid oxidase	Sus scrofa (pig)	IC50	100.0000	2	2
D(1A) dopamine receptor	Homo sapiens (human)	IC50	0.4790	1	1
D(1A) dopamine receptor	Homo sapiens (human)	Ki	0.2080	6	10
D(1B) dopamine receptor	Mus musculus (house mouse)	IC50	35.0000	1	1
D(1B) dopamine receptor	Rattus norvegicus (Norway rat)	Ki	0.0020	1	1
D(2) dopamine receptor	Homo sapiens (human)	IC50	0.0094	6	6
D(2) dopamine receptor	Mus musculus (house mouse)	IC50	11.6820	2	3
D(2) dopamine receptor	Rattus norvegicus (Norway rat)	IC50	0.0128	4	6
D(2) dopamine receptor	Homo sapiens (human)	Ki	0.0029	33	41
D(2) dopamine receptor	Rattus norvegicus (Norway rat)	Ki	0.0283	19	30
D(3) dopamine receptor	Homo sapiens (human)	IC50	0.0536	4	4
D(3) dopamine receptor	Mus musculus (house mouse)	IC50	35.0000	1	1
D(3) dopamine receptor	Homo sapiens (human)	Ki	0.0073	21	26
D(3) dopamine receptor	Rattus norvegicus (Norway rat)	Ki	0.0170	2	2
D(4) dopamine receptor	Homo sapiens (human)	IC50	0.0005	1	1
D(4) dopamine receptor	Mus musculus (house mouse)	IC50	35.0000	1	1
D(4) dopamine receptor	Homo sapiens (human)	Ki	0.0151	11	15
D(4) dopamine receptor	Rattus norvegicus (Norway rat)	Ki	0.0020	1	1
Delta-type opioid receptor	Mus musculus (house mouse)	Ki	0.4400	1	1
Delta-type opioid receptor	Rattus norvegicus (Norway rat)	Ki	0.1100	1	1
DNA-dependent protein kinase catalytic subunit	Homo sapiens (human)	IC50	10,000.0000	1	1
Endochitinase B1	Aspergillus fumigatus	IC50	363.0000	1	2
Endothelin receptor type B	Homo sapiens (human)	Ki	0.0200	2	2
Endothelin receptor type B	Rattus norvegicus (Norway rat)	Ki	0.0200	1	1
GABA theta subunit	Rattus norvegicus (Norway rat)	IC50	0.0054	5	8
GABA theta subunit	Rattus norvegicus (Norway rat)	Ki	0.0040	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	Homo sapiens (human)	IC50	0.0160	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)	IC50	0.0054	5	8
Gamma-aminobutyric acid receptor subunit alpha-1	Homo sapiens (human)	Ki	0.0085	2	2
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)	Ki	0.0040	1	1
Gamma-aminobutyric acid receptor subunit alpha-2	Homo sapiens (human)	IC50	0.0160	1	1
Gamma-aminobutyric acid receptor subunit alpha-2	Rattus norvegicus (Norway rat)	IC50	0.0054	5	8
Gamma-aminobutyric acid receptor subunit alpha-2	Homo sapiens (human)	Ki	0.0085	2	2
Gamma-aminobutyric acid receptor subunit alpha-2	Rattus norvegicus (Norway rat)	Ki	0.0040	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	Homo sapiens (human)	IC50	0.0160	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	Rattus norvegicus (Norway rat)	IC50	0.0054	5	8
Gamma-aminobutyric acid receptor subunit alpha-3	Homo sapiens (human)	Ki	0.0085	2	2
Gamma-aminobutyric acid receptor subunit alpha-3	Rattus norvegicus (Norway rat)	Ki	0.0040	1	1
Gamma-aminobutyric acid receptor subunit alpha-4	Homo sapiens (human)	IC50	0.0160	1	1
Gamma-aminobutyric acid receptor subunit alpha-4	Rattus norvegicus (Norway rat)	IC50	0.0054	5	8
Gamma-aminobutyric acid receptor subunit alpha-4	Homo sapiens (human)	Ki	0.0085	2	2
Gamma-aminobutyric acid receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Ki	0.0040	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	Homo sapiens (human)	IC50	0.0160	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	Rattus norvegicus (Norway rat)	IC50	0.0054	5	8
Gamma-aminobutyric acid receptor subunit alpha-5	Homo sapiens (human)	Ki	0.0085	2	2
Gamma-aminobutyric acid receptor subunit alpha-5	Rattus norvegicus (Norway rat)	Ki	0.0040	1	1
Gamma-aminobutyric acid receptor subunit alpha-6	Homo sapiens (human)	IC50	0.0160	1	1
Gamma-aminobutyric acid receptor subunit alpha-6	Rattus norvegicus (Norway rat)	IC50	0.0054	5	8
Gamma-aminobutyric acid receptor subunit alpha-6	Homo sapiens (human)	Ki	0.0085	2	2
Gamma-aminobutyric acid receptor subunit alpha-6	Rattus norvegicus (Norway rat)	Ki	0.0040	1	1
Gamma-aminobutyric acid receptor subunit beta-1	Homo sapiens (human)	IC50	0.0160	1	1
Gamma-aminobutyric acid receptor subunit beta-1	Rattus norvegicus (Norway rat)	IC50	0.0054	5	8
Gamma-aminobutyric acid receptor subunit beta-1	Homo sapiens (human)	Ki	0.0085	2	2
Gamma-aminobutyric acid receptor subunit beta-1	Rattus norvegicus (Norway rat)	Ki	0.0040	1	1
Gamma-aminobutyric acid receptor subunit beta-2	Homo sapiens (human)	IC50	0.0160	1	1
Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)	IC50	0.0054	5	8
Gamma-aminobutyric acid receptor subunit beta-2	Homo sapiens (human)	Ki	0.0085	2	2
Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)	Ki	0.0040	1	1
Gamma-aminobutyric acid receptor subunit beta-3	Homo sapiens (human)	IC50	0.0160	1	1
Gamma-aminobutyric acid receptor subunit beta-3	Rattus norvegicus (Norway rat)	IC50	0.0054	5	8
Gamma-aminobutyric acid receptor subunit beta-3	Homo sapiens (human)	Ki	0.0085	2	2
Gamma-aminobutyric acid receptor subunit beta-3	Rattus norvegicus (Norway rat)	Ki	0.0040	1	1
Gamma-aminobutyric acid receptor subunit delta	Homo sapiens (human)	IC50	0.0160	1	1
Gamma-aminobutyric acid receptor subunit delta	Rattus norvegicus (Norway rat)	IC50	0.0054	5	8
Gamma-aminobutyric acid receptor subunit delta	Homo sapiens (human)	Ki	0.0085	2	2
Gamma-aminobutyric acid receptor subunit delta	Rattus norvegicus (Norway rat)	Ki	0.0040	1	1
Gamma-aminobutyric acid receptor subunit epsilon	Homo sapiens (human)	IC50	0.0160	1	1
Gamma-aminobutyric acid receptor subunit epsilon	Rattus norvegicus (Norway rat)	IC50	0.0054	5	8
Gamma-aminobutyric acid receptor subunit epsilon	Homo sapiens (human)	Ki	0.0085	2	2
Gamma-aminobutyric acid receptor subunit epsilon	Rattus norvegicus (Norway rat)	Ki	0.0040	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	Homo sapiens (human)	IC50	0.0160	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	Rattus norvegicus (Norway rat)	IC50	0.0055	6	9
Gamma-aminobutyric acid receptor subunit gamma-1	Homo sapiens (human)	Ki	0.0085	2	2
Gamma-aminobutyric acid receptor subunit gamma-1	Rattus norvegicus (Norway rat)	Ki	0.0040	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	Homo sapiens (human)	IC50	0.0160	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)	IC50	0.0054	5	8
Gamma-aminobutyric acid receptor subunit gamma-2	Homo sapiens (human)	Ki	0.0085	2	2
Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)	Ki	0.0040	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	Homo sapiens (human)	IC50	0.0160	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	Rattus norvegicus (Norway rat)	IC50	0.0054	5	8
Gamma-aminobutyric acid receptor subunit gamma-3	Homo sapiens (human)	Ki	0.0085	2	2
Gamma-aminobutyric acid receptor subunit gamma-3	Rattus norvegicus (Norway rat)	Ki	0.0040	1	1
Gamma-aminobutyric acid receptor subunit pi	Homo sapiens (human)	IC50	0.0160	1	1
Gamma-aminobutyric acid receptor subunit pi	Rattus norvegicus (Norway rat)	IC50	0.0054	5	8
Gamma-aminobutyric acid receptor subunit pi	Homo sapiens (human)	Ki	0.0085	2	2
Gamma-aminobutyric acid receptor subunit pi	Rattus norvegicus (Norway rat)	Ki	0.0040	1	1
Gamma-aminobutyric acid receptor subunit theta	Homo sapiens (human)	IC50	0.0160	1	1
Gamma-aminobutyric acid receptor subunit theta	Homo sapiens (human)	Ki	0.0085	2	2
Glutamate receptor ionotropic, NMDA 1	Homo sapiens (human)	IC50	0.5563	3	3
Glutamate receptor ionotropic, NMDA 1	Homo sapiens (human)	Ki	0.0324	3	3
Glutamate receptor ionotropic, NMDA 1	Rattus norvegicus (Norway rat)	IC50	0.1299	3	3
Glutamate receptor ionotropic, NMDA 1	Rattus norvegicus (Norway rat)	Ki	0.0380	1	2
Glutamate receptor ionotropic, NMDA 2A	Homo sapiens (human)	IC50	0.2050	2	2
Glutamate receptor ionotropic, NMDA 2A	Homo sapiens (human)	Ki	0.0324	3	3
Glutamate receptor ionotropic, NMDA 2A	Rattus norvegicus (Norway rat)	IC50	0.1299	3	3
Glutamate receptor ionotropic, NMDA 2A	Rattus norvegicus (Norway rat)	Ki	0.0380	1	2
Glutamate receptor ionotropic, NMDA 2B	Homo sapiens (human)	IC50	1.2589	1	1
Glutamate receptor ionotropic, NMDA 2B	Rattus norvegicus (Norway rat)	IC50	0.1299	3	3
Glutamate receptor ionotropic, NMDA 2B	Homo sapiens (human)	Ki	0.0324	3	3
Glutamate receptor ionotropic, NMDA 2B	Rattus norvegicus (Norway rat)	Ki	0.0380	1	2
Glutamate receptor ionotropic, NMDA 2C	Rattus norvegicus (Norway rat)	IC50	0.1299	3	3
Glutamate receptor ionotropic, NMDA 2C	Homo sapiens (human)	Ki	0.0324	3	3
Glutamate receptor ionotropic, NMDA 2C	Rattus norvegicus (Norway rat)	Ki	0.1743	3	4
Glutamate receptor ionotropic, NMDA 2D	Rattus norvegicus (Norway rat)	IC50	0.1299	3	3
Glutamate receptor ionotropic, NMDA 2D	Homo sapiens (human)	Ki	0.0324	3	3
Glutamate receptor ionotropic, NMDA 2D	Rattus norvegicus (Norway rat)	Ki	0.0380	1	2
Glutamate receptor ionotropic, NMDA 3A	Rattus norvegicus (Norway rat)	IC50	0.1299	3	3
Glutamate receptor ionotropic, NMDA 3A	Homo sapiens (human)	Ki	0.0324	3	3
Glutamate receptor ionotropic, NMDA 3A	Rattus norvegicus (Norway rat)	Ki	0.0380	1	2
Glutamate receptor ionotropic, NMDA 3B	Rattus norvegicus (Norway rat)	IC50	0.1299	3	3
Glutamate receptor ionotropic, NMDA 3B	Homo sapiens (human)	Ki	0.0324	3	3
Glutamate receptor ionotropic, NMDA 3B	Rattus norvegicus (Norway rat)	Ki	0.0380	1	2
Glycogen phosphorylase, brain form	Homo sapiens (human)	Ki	49.6000	1	1
Glycogen phosphorylase, liver form	Rattus norvegicus (Norway rat)	IC50	648.0000	1	1
Glycogen phosphorylase, muscle form	Oryctolagus cuniculus (rabbit)	IC50	159.1933	13	15
Glycogen phosphorylase, muscle form	Rattus norvegicus (Norway rat)	IC50	182.0000	1	1
Glycogen phosphorylase, muscle form	Homo sapiens (human)	Ki	49.6000	1	1
Guanine deaminase	Homo sapiens (human)	Ki	10.2000	1	1
Histamine H1 receptor	Cavia porcellus (domestic guinea pig)	IC50	0.0970	1	1
Histamine H1 receptor	Homo sapiens (human)	IC50	0.4515	6	6
Histamine H1 receptor	Cavia porcellus (domestic guinea pig)	Ki	0.0376	2	2
Histamine H1 receptor	Homo sapiens (human)	Ki	0.0716	9	12
Histamine H2 receptor	Homo sapiens (human)	IC50	1.4830	1	1
Histamine H2 receptor	Homo sapiens (human)	Ki	1.4580	1	1
Histamine H3 receptor	Homo sapiens (human)	Ki	1.1055	1	1
Histone deacetylase 1	Homo sapiens (human)	IC50	1,262.6014	7	7
Histone deacetylase 1	Homo sapiens (human)	Ki	564.0000	1	1
Histone deacetylase 11	Homo sapiens (human)	IC50	4,117.5000	2	2
Histone deacetylase 11	Homo sapiens (human)	Ki	564.0000	1	1
Histone deacetylase 2	Homo sapiens (human)	IC50	1,819.9480	5	5
Histone deacetylase 2	Homo sapiens (human)	Ki	564.0000	1	1
Histone deacetylase 3	Homo sapiens (human)	IC50	1,846.1340	5	5
Histone deacetylase 3	Homo sapiens (human)	Ki	564.0000	1	1
Histone deacetylase 4	Homo sapiens (human)	IC50	2,808.7500	4	4
Histone deacetylase 4	Homo sapiens (human)	Ki	564.0000	1	1
Histone deacetylase 5	Homo sapiens (human)	IC50	2,808.7500	4	4
Histone deacetylase 5	Homo sapiens (human)	Ki	564.0000	1	1
Histone deacetylase 6	Homo sapiens (human)	IC50	2,290.0020	5	5
Histone deacetylase 6	Homo sapiens (human)	Ki	564.0000	1	1
Histone deacetylase 7	Homo sapiens (human)	IC50	3,411.6667	3	3
Histone deacetylase 7	Homo sapiens (human)	Ki	564.0000	1	1
Histone deacetylase 8	Homo sapiens (human)	IC50	2,130.5750	4	4
Histone deacetylase 8	Homo sapiens (human)	Ki	564.0000	1	1
Histone deacetylase 9	Homo sapiens (human)	IC50	3,411.6667	3	3
Histone deacetylase 9	Homo sapiens (human)	Ki	564.0000	1	1
Liver carboxylesterase 1	Homo sapiens (human)	Ki	363.0000	1	1
Liver carboxylesterase B-1	Rattus norvegicus (Norway rat)	IC50	0.0450	1	1
Lysosomal Pro-X carboxypeptidase	Homo sapiens (human)	IC50	0.0910	1	1
Mu-type opioid receptor	Cavia porcellus (domestic guinea pig)	Ki	0.2260	2	2
Mu-type opioid receptor	Rattus norvegicus (Norway rat)	Ki	0.4400	1	1
Multidrug and toxin extrusion protein 1	Homo sapiens (human)	IC50	1.6000	1	1
Multidrug and toxin extrusion protein 2	Homo sapiens (human)	IC50	291.0000	1	1
Multidrug resistance-associated protein 4	Homo sapiens (human)	IC50	133.0000	1	3
Muscarinic acetylcholine receptor M1	Rattus norvegicus (Norway rat)	IC50	360.0000	1	2
Muscarinic acetylcholine receptor M1	Homo sapiens (human)	Ki	11.7857	4	7
Muscarinic acetylcholine receptor M1	Rattus norvegicus (Norway rat)	Ki	49.6000	1	1
Muscarinic acetylcholine receptor M2	Rattus norvegicus (Norway rat)	IC50	360.0000	1	1
Muscarinic acetylcholine receptor M2	Homo sapiens (human)	Ki	19.8667	2	3
Muscarinic acetylcholine receptor M2	Rattus norvegicus (Norway rat)	Ki	49.6000	1	1
Muscarinic acetylcholine receptor M3	Homo sapiens (human)	IC50	55.0000	2	2
Muscarinic acetylcholine receptor M3	Rattus norvegicus (Norway rat)	IC50	360.0000	1	1
Muscarinic acetylcholine receptor M3	Homo sapiens (human)	Ki	19.8667	2	3
Muscarinic acetylcholine receptor M3	Rattus norvegicus (Norway rat)	Ki	49.6000	1	1
Muscarinic acetylcholine receptor M4	Rattus norvegicus (Norway rat)	IC50	360.0000	1	1
Muscarinic acetylcholine receptor M4	Homo sapiens (human)	Ki	19.8667	2	3
Muscarinic acetylcholine receptor M4	Mus musculus (house mouse)	Ki	2.1100	1	1
Muscarinic acetylcholine receptor M4	Rattus norvegicus (Norway rat)	Ki	17.2398	3	3
Muscarinic acetylcholine receptor M5	Rattus norvegicus (Norway rat)	IC50	360.0000	1	1
Muscarinic acetylcholine receptor M5	Homo sapiens (human)	Ki	19.8667	2	3
Muscarinic acetylcholine receptor M5	Rattus norvegicus (Norway rat)	Ki	49.6000	1	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	Homo sapiens (human)	IC50	100.0000	1	1
Neuronal acetylcholine receptor subunit alpha-10	Rattus norvegicus (Norway rat)	IC50	0.0050	2	2
Neuronal acetylcholine receptor subunit alpha-10	Rattus norvegicus (Norway rat)	Ki	0.0070	3	4
Neuronal acetylcholine receptor subunit alpha-2	Mus musculus (house mouse)	IC50	0.0040	1	1
Neuronal acetylcholine receptor subunit alpha-2	Rattus norvegicus (Norway rat)	IC50	0.0050	2	2
Neuronal acetylcholine receptor subunit alpha-2	Homo sapiens (human)	Ki	0.0595	3	3
Neuronal acetylcholine receptor subunit alpha-2	Mus musculus (house mouse)	Ki	0.0012	1	1
Neuronal acetylcholine receptor subunit alpha-2	Rattus norvegicus (Norway rat)	Ki	0.0438	27	28
Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)	IC50	0.3899	4	4
Neuronal acetylcholine receptor subunit alpha-3	Mus musculus (house mouse)	IC50	0.0040	1	1
Neuronal acetylcholine receptor subunit alpha-3	Rattus norvegicus (Norway rat)	IC50	5.0025	4	4
Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)	Ki	0.3763	20	20
Neuronal acetylcholine receptor subunit alpha-3	Mus musculus (house mouse)	Ki	0.0841	2	2
Neuronal acetylcholine receptor subunit alpha-3	Rattus norvegicus (Norway rat)	Ki	0.2178	37	42
Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)	IC50	0.3456	10	12
Neuronal acetylcholine receptor subunit alpha-4	Mus musculus (house mouse)	IC50	0.0055	2	2
Neuronal acetylcholine receptor subunit alpha-4	Rattus norvegicus (Norway rat)	IC50	0.0046	3	3
Neuronal acetylcholine receptor subunit alpha-4	Gallus gallus (chicken)	Ki	0.0019	1	1
Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)	Ki	0.3444	30	30
Neuronal acetylcholine receptor subunit alpha-4	Mus musculus (house mouse)	Ki	0.0012	1	1
Neuronal acetylcholine receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Ki	0.0204	72	85
Neuronal acetylcholine receptor subunit alpha-5	Mus musculus (house mouse)	IC50	0.0040	1	1
Neuronal acetylcholine receptor subunit alpha-5	Rattus norvegicus (Norway rat)	IC50	0.0050	2	2
Neuronal acetylcholine receptor subunit alpha-5	Mus musculus (house mouse)	Ki	0.0012	1	1
Neuronal acetylcholine receptor subunit alpha-5	Rattus norvegicus (Norway rat)	Ki	0.0070	3	4
Neuronal acetylcholine receptor subunit alpha-6	Homo sapiens (human)	IC50	0.0848	1	1
Neuronal acetylcholine receptor subunit alpha-6	Mus musculus (house mouse)	IC50	0.0040	1	1
Neuronal acetylcholine receptor subunit alpha-6	Rattus norvegicus (Norway rat)	IC50	0.0050	2	2
Neuronal acetylcholine receptor subunit alpha-6	Mus musculus (house mouse)	Ki	0.0012	1	1
Neuronal acetylcholine receptor subunit alpha-6	Rattus norvegicus (Norway rat)	Ki	0.0070	3	4
Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)	IC50	14.3000	2	2
Neuronal acetylcholine receptor subunit alpha-7	Mus musculus (house mouse)	IC50	0.0040	1	1
Neuronal acetylcholine receptor subunit alpha-7	Rattus norvegicus (Norway rat)	IC50	0.0087	3	3
Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)	Ki	5.9317	17	19
Neuronal acetylcholine receptor subunit alpha-7	Mus musculus (house mouse)	Ki	0.2406	2	2
Neuronal acetylcholine receptor subunit alpha-7	Rattus norvegicus (Norway rat)	Ki	3.1729	16	20
Neuronal acetylcholine receptor subunit alpha-9	Rattus norvegicus (Norway rat)	IC50	0.0041	3	3
Neuronal acetylcholine receptor subunit alpha-9	Rattus norvegicus (Norway rat)	Ki	0.0070	3	4
Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)	IC50	0.3256	11	13
Neuronal acetylcholine receptor subunit beta-2	Mus musculus (house mouse)	IC50	0.0040	1	1
Neuronal acetylcholine receptor subunit beta-2	Rattus norvegicus (Norway rat)	IC50	0.0046	3	3
Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)	Ki	0.3399	30	30
Neuronal acetylcholine receptor subunit beta-2	Mus musculus (house mouse)	Ki	0.0024	2	2
Neuronal acetylcholine receptor subunit beta-2	Rattus norvegicus (Norway rat)	Ki	0.0124	76	85
Neuronal acetylcholine receptor subunit beta-3	Homo sapiens (human)	IC50	0.0848	1	1
Neuronal acetylcholine receptor subunit beta-3	Mus musculus (house mouse)	IC50	0.0040	1	1
Neuronal acetylcholine receptor subunit beta-3	Rattus norvegicus (Norway rat)	IC50	0.0050	2	2
Neuronal acetylcholine receptor subunit beta-3	Mus musculus (house mouse)	Ki	0.0012	1	1
Neuronal acetylcholine receptor subunit beta-3	Rattus norvegicus (Norway rat)	Ki	0.0070	3	4
Neuronal acetylcholine receptor subunit beta-4	Homo sapiens (human)	IC50	0.7150	2	2
Neuronal acetylcholine receptor subunit beta-4	Mus musculus (house mouse)	IC50	0.0040	1	1
Neuronal acetylcholine receptor subunit beta-4	Rattus norvegicus (Norway rat)	IC50	5.0025	4	4
Neuronal acetylcholine receptor subunit beta-4	Homo sapiens (human)	Ki	0.3463	22	22
Neuronal acetylcholine receptor subunit beta-4	Mus musculus (house mouse)	Ki	0.0572	3	3
Neuronal acetylcholine receptor subunit beta-4	Rattus norvegicus (Norway rat)	Ki	0.1748	54	63
Nuclear receptor subfamily 3 group C member 3	Bos taurus (cattle)	IC50	4.1901	1	1
Nuclear receptor subfamily 3 group C member 3	Bos taurus (cattle)	Ki	3.4328	1	1
Palmitoleoyl-protein carboxylesterase NOTUM	Homo sapiens (human)	IC50	18.6000	1	1
Phenylethanolamine N-methyltransferase	Bos taurus (cattle)	Ki	3,700.0000	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)	IC50	3,630.0000	1	1
Phosphodiesterase	Rattus norvegicus (Norway rat)	IC50	70.0000	1	1
Polyamine deacetylase HDAC10	Homo sapiens (human)	IC50	4,117.5000	2	2
Polyamine deacetylase HDAC10	Homo sapiens (human)	Ki	564.0000	1	1
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	IC50	43.6627	22	34
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	Ki	2.1764	2	2
Renin	Homo sapiens (human)	Ki	15.0000	1	1
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	IC50	100.0000	1	1
Replicase polyprotein 1ab	Severe acute respiratory syndrome-related coronavirus	IC50	100.0000	1	1
Serine-protein kinase ATM	Homo sapiens (human)	IC50	200.0000	1	1
Serine/threonine-protein kinase ATR	Homo sapiens (human)	IC50	1,100.0000	1	1
Serine/threonine-protein kinase mTOR	Homo sapiens (human)	IC50	400.0000	1	1
Sigma non-opioid intracellular receptor 1	Homo sapiens (human)	IC50	0.9550	1	1
Sigma non-opioid intracellular receptor 1	Rattus norvegicus (Norway rat)	IC50	0.5300	1	1
Sigma non-opioid intracellular receptor 1	Cavia porcellus (domestic guinea pig)	Ki	10.0000	1	1
Sigma non-opioid intracellular receptor 1	Homo sapiens (human)	Ki	4.7050	2	2
Sigma non-opioid intracellular receptor 1	Rattus norvegicus (Norway rat)	Ki	1.0900	1	1
Sodium channel protein type 5 subunit alpha	Homo sapiens (human)	IC50	102.0000	1	1
Sodium- and chloride-dependent betaine transporter	Rattus norvegicus (Norway rat)	IC50	0.0032	1	1
Sodium- and chloride-dependent GABA transporter 1	Rattus norvegicus (Norway rat)	IC50	0.0032	1	1
Sodium- and chloride-dependent GABA transporter 2	Rattus norvegicus (Norway rat)	IC50	0.0032	1	1
Sodium- and chloride-dependent GABA transporter 3	Rattus norvegicus (Norway rat)	IC50	0.0032	1	1
Sodium-dependent dopamine transporter	Rattus norvegicus (Norway rat)	IC50	0.1514	1	2
Sodium-dependent dopamine transporter	Rattus norvegicus (Norway rat)	Ki	0.3321	3	5
Sodium-dependent dopamine transporter	Homo sapiens (human)	Ki	0.0013	1	1
Sodium-dependent serotonin transporter	Homo sapiens (human)	Ki	0.5108	2	3
Sodium-dependent serotonin transporter	Rattus norvegicus (Norway rat)	Ki	1.0900	1	4
Soluble acetylcholine receptor	Aplysia californica (California sea hare)	Ki	1.0466	3	3
Solute carrier family 22 member 1	Rattus norvegicus (Norway rat)	Ki	64.3000	1	1
Solute carrier family 22 member 2	Homo sapiens (human)	IC50	11.0000	1	1
Solute carrier family 22 member 2	Rattus norvegicus (Norway rat)	Ki	50.5000	1	1
Solute carrier family 22 member 3	Rattus norvegicus (Norway rat)	IC50	248.0000	1	1
sphingosine 1-phosphate receptor 3	Homo sapiens (human)	IC50	50.0000	1	1
Synaptic vesicular amine transporter	Rattus norvegicus (Norway rat)	Ki	41.2800	2	2
Tissue factor	Homo sapiens (human)	IC50	1,750.0000	2	2
Translocator protein	Rattus norvegicus (Norway rat)	Ki	0.5063	2	4
Transporter	Rattus norvegicus (Norway rat)	Ki	9.7505	3	4
UDP-glucuronosyltransferase 2B7	Homo sapiens (human)	Ki	1,600.0000	1	1
Vesicular acetylcholine transporter	Rattus norvegicus (Norway rat)	Ki	1.0330	1	1
Voltage-dependent L-type calcium channel subunit alpha-1C	Homo sapiens (human)	IC50	79.6000	2	2
Voltage-dependent L-type calcium channel subunit alpha-1D	Homo sapiens (human)	IC50	34.2000	1	1
Voltage-dependent L-type calcium channel subunit alpha-1F	Homo sapiens (human)	IC50	34.2000	1	1
Voltage-dependent L-type calcium channel subunit alpha-1S	Homo sapiens (human)	IC50	34.2000	1	1

Activation Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
5-hydroxytryptamine receptor 1A	Homo sapiens (human)	EC50	10.0000	1	1
5-hydroxytryptamine receptor 1A	Homo sapiens (human)	Kd	0.1460	2	3
5-hydroxytryptamine receptor 1A	Rattus norvegicus (Norway rat)	Kd	3.0200	1	2
5-hydroxytryptamine receptor 1B	Rattus norvegicus (Norway rat)	Kd	3.0200	1	2
5-hydroxytryptamine receptor 1D	Rattus norvegicus (Norway rat)	Kd	3.0200	1	2
5-hydroxytryptamine receptor 1F	Rattus norvegicus (Norway rat)	Kd	3.0200	1	2
5-hydroxytryptamine receptor 2A	Rattus norvegicus (Norway rat)	Kd	2.0133	2	3
5-hydroxytryptamine receptor 2B	Rattus norvegicus (Norway rat)	Kd	3.0200	1	2
5-hydroxytryptamine receptor 2C	Rattus norvegicus (Norway rat)	Kd	3.0200	1	2
5-hydroxytryptamine receptor 3A	Rattus norvegicus (Norway rat)	Kd	3.0200	1	2
5-hydroxytryptamine receptor 3B	Rattus norvegicus (Norway rat)	Kd	3.0200	1	2
5-hydroxytryptamine receptor 4	Rattus norvegicus (Norway rat)	Kd	3.0200	1	2
5-hydroxytryptamine receptor 5A	Rattus norvegicus (Norway rat)	Kd	3.0200	1	2
5-hydroxytryptamine receptor 5B	Rattus norvegicus (Norway rat)	Kd	3.0200	1	2
5-hydroxytryptamine receptor 6	Rattus norvegicus (Norway rat)	Kd	3.0200	1	2
5-hydroxytryptamine receptor 7	Rattus norvegicus (Norway rat)	Kd	2.0133	2	3
Acetylcholine receptor subunit alpha	Homo sapiens (human)	EC50	25.3333	3	3
Acetylcholine receptor subunit alpha	Tetronarce californica (Pacific electric ray)	EC50	60.0000	1	1
Acetylcholine receptor subunit beta	Homo sapiens (human)	EC50	29.0000	3	3
Acetylcholine receptor subunit beta	Tetronarce californica (Pacific electric ray)	EC50	60.0000	1	1
Acetylcholine receptor subunit delta	Homo sapiens (human)	EC50	33.0000	2	2
Acetylcholine receptor subunit delta	Tetronarce californica (Pacific electric ray)	EC50	110.0000	2	2
Acetylcholine receptor subunit epsilon	Homo sapiens (human)	EC50	65.0000	1	1
Acetylcholine receptor subunit gamma	Homo sapiens (human)	EC50	33.0000	2	2
Acetylcholine receptor subunit gamma	Tetronarce californica (Pacific electric ray)	EC50	60.0000	1	1
Acetylcholine-binding protein	Lymnaea stagnalis (great pond snail)	Kd	0.2931	3	5
Adenosine receptor A1	Homo sapiens (human)	Kd	45.0000	1	1
Adenosine receptor A2a	Homo sapiens (human)	Kd	15.3144	2	2
Albumin	Rattus norvegicus (Norway rat)	Kd	43.8000	1	1
alternatively spliced Trp4	Mus musculus (house mouse)	EC50	6.6827	1	1
Caspase-3	Homo sapiens (human)	EC50	50.0000	2	2
Chain A, Glycogen phosphorylase, liver form	Homo sapiens (human)	Kd	100.0000	1	8
Chain A, Immunoglobulin	Mus musculus (house mouse)	Kd	0.0020	1	1
Chain B, Immunoglobulin	Mus musculus (house mouse)	Kd	0.0020	1	1
Cytochrome P450 2A13	Homo sapiens (human)	Kd	54.0000	1	1
Cytochrome P450 2A6	Homo sapiens (human)	Kd	470.0000	1	1
D(2) dopamine receptor	Homo sapiens (human)	Kd	0.0001	2	2
Gamma-aminobutyric acid receptor subunit alpha-1	Homo sapiens (human)	EC50	5.8308	3	5
Gamma-aminobutyric acid receptor subunit alpha-2	Homo sapiens (human)	EC50	5.7270	3	5
Gamma-aminobutyric acid receptor subunit alpha-3	Homo sapiens (human)	EC50	5.5695	3	5
Gamma-aminobutyric acid receptor subunit alpha-4	Homo sapiens (human)	EC50	27.0000	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	Homo sapiens (human)	EC50	27.0000	1	1
Gamma-aminobutyric acid receptor subunit alpha-6	Homo sapiens (human)	EC50	27.0000	1	1
Gamma-aminobutyric acid receptor subunit beta-1	Homo sapiens (human)	EC50	27.0000	1	1
Gamma-aminobutyric acid receptor subunit beta-2	Homo sapiens (human)	EC50	2.4336	7	13
Gamma-aminobutyric acid receptor subunit beta-3	Homo sapiens (human)	EC50	27.0000	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	Homo sapiens (human)	EC50	0.3864	6	12
Gamma-aminobutyric acid receptor subunit rho-1	Homo sapiens (human)	EC50	1.0806	4	6
Gamma-aminobutyric acid receptor subunit rho-1	Homo sapiens (human)	Kd	2.3000	1	1
Gamma-aminobutyric acid receptor subunit rho-2	Homo sapiens (human)	Kd	1.4000	1	1
Glycine receptor subunit alpha-1	Homo sapiens (human)	EC50	0.3200	1	1
Glycoprotein IIb	Oryctolagus cuniculus (rabbit)	EC50	1.5068	1	4
HLA class I histocompatibility antigen, A alpha chain	Homo sapiens (human)	Kd	2.5000	1	1
Integrin beta	Oryctolagus cuniculus (rabbit)	EC50	1.5068	1	4
Muscarinic acetylcholine receptor M1	Mus musculus (house mouse)	Kd	9.1000	1	1
Muscarinic acetylcholine receptor M1	Rattus norvegicus (Norway rat)	Kd	9.1000	1	1
Muscarinic acetylcholine receptor M2	Mus musculus (house mouse)	Kd	9.1000	1	1
Muscarinic acetylcholine receptor M2	Rattus norvegicus (Norway rat)	Kd	9.1000	1	1
Muscarinic acetylcholine receptor M3	Mus musculus (house mouse)	Kd	9.1000	1	1
Muscarinic acetylcholine receptor M3	Rattus norvegicus (Norway rat)	Kd	9.1000	1	1
Muscarinic acetylcholine receptor M4	Mus musculus (house mouse)	Kd	9.1000	1	1
Muscarinic acetylcholine receptor M4	Rattus norvegicus (Norway rat)	Kd	9.1000	1	1
Muscarinic acetylcholine receptor M5	Mus musculus (house mouse)	Kd	9.1000	1	1
Muscarinic acetylcholine receptor M5	Rattus norvegicus (Norway rat)	Kd	9.1000	1	1
Neuronal acetylcholine receptor subunit alpha-10	Rattus norvegicus (Norway rat)	EC50	40.6667	2	3
Neuronal acetylcholine receptor subunit alpha-10	Rattus norvegicus (Norway rat)	Kd	14,352.0000	3	3
Neuronal acetylcholine receptor subunit alpha-2	Rattus norvegicus (Norway rat)	EC50	35.5000	2	2
Neuronal acetylcholine receptor subunit alpha-2	Rattus norvegicus (Norway rat)	Kd	14,352.0000	3	3
Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)	EC50	21.3260	14	15
Neuronal acetylcholine receptor subunit alpha-3	Rattus norvegicus (Norway rat)	EC50	30.2517	7	8
Neuronal acetylcholine receptor subunit alpha-3	Rattus norvegicus (Norway rat)	Kd	14,352.0000	3	3
Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)	EC50	3.1424	20	24
Neuronal acetylcholine receptor subunit alpha-4	Mus musculus (house mouse)	EC50	0.7222	1	2
Neuronal acetylcholine receptor subunit alpha-4	Rattus norvegicus (Norway rat)	EC50	10.7398	12	12
Neuronal acetylcholine receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Kd	14,352.0000	3	3
Neuronal acetylcholine receptor subunit alpha-5	Homo sapiens (human)	EC50	30.0000	1	1
Neuronal acetylcholine receptor subunit alpha-5	Rattus norvegicus (Norway rat)	EC50	35.5000	2	2
Neuronal acetylcholine receptor subunit alpha-5	Rattus norvegicus (Norway rat)	Kd	14,352.0000	3	3
Neuronal acetylcholine receptor subunit alpha-6	Homo sapiens (human)	EC50	0.1270	1	1
Neuronal acetylcholine receptor subunit alpha-6	Rattus norvegicus (Norway rat)	EC50	35.5000	2	2
Neuronal acetylcholine receptor subunit alpha-6	Rattus norvegicus (Norway rat)	Kd	14,352.0000	3	3
Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)	EC50	55.2158	6	6
Neuronal acetylcholine receptor subunit alpha-7	Rattus norvegicus (Norway rat)	EC50	3,948.0836	10	11
Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)	Kd	0.0011	1	1
Neuronal acetylcholine receptor subunit alpha-7	Rattus norvegicus (Norway rat)	Kd	14,352.0000	3	3
Neuronal acetylcholine receptor subunit alpha-9	Rattus norvegicus (Norway rat)	EC50	35.5000	2	2
Neuronal acetylcholine receptor subunit alpha-9	Rattus norvegicus (Norway rat)	Kd	14,352.0000	3	3
Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)	EC50	9.3127	23	27
Neuronal acetylcholine receptor subunit beta-2	Mus musculus (house mouse)	EC50	0.7222	1	2
Neuronal acetylcholine receptor subunit beta-2	Rattus norvegicus (Norway rat)	EC50	10.7398	12	12
Neuronal acetylcholine receptor subunit beta-2	Rattus norvegicus (Norway rat)	Kd	14,352.0000	3	3
Neuronal acetylcholine receptor subunit beta-3	Homo sapiens (human)	EC50	10.5635	2	2
Neuronal acetylcholine receptor subunit beta-3	Rattus norvegicus (Norway rat)	EC50	35.5000	2	2
Neuronal acetylcholine receptor subunit beta-3	Rattus norvegicus (Norway rat)	Kd	14,352.0000	3	3
Neuronal acetylcholine receptor subunit beta-4	Homo sapiens (human)	EC50	13.6576	14	15
Neuronal acetylcholine receptor subunit beta-4	Rattus norvegicus (Norway rat)	EC50	30.2517	7	8
Neuronal acetylcholine receptor subunit beta-4	Rattus norvegicus (Norway rat)	Kd	14,352.0000	3	3
Palmitoleoyl-protein carboxylesterase NOTUM	Homo sapiens (human)	EC50	45.8000	1	1
Palmitoleoyl-protein carboxylesterase NOTUM	Homo sapiens (human)	Kd	85.0000	1	1
Potassium channel subfamily K member 2	Homo sapiens (human)	EC50	377.0000	1	1
Sodium-dependent noradrenaline transporter	Homo sapiens (human)	EC50	0.9200	1	1
Sodium-dependent serotonin transporter	Homo sapiens (human)	EC50	1.3000	1	1
Trace amine-associated receptor 1	Homo sapiens (human)	EC50	1.4000	2	2
Trace amine-associated receptor 1	Macaca mulatta (Rhesus monkey)	EC50	5.3000	1	1
Trace amine-associated receptor 1	Mus musculus (house mouse)	EC50	0.6217	5	5
Trace amine-associated receptor 1	Rattus norvegicus (Norway rat)	EC50	0.8173	4	4
Transient receptor potential cation channel subfamily A member 1	Homo sapiens (human)	EC50	152,369.0000	2	3
Transient receptor potential cation channel subfamily A member 1	Mus musculus (house mouse)	EC50	10.0000	1	1
Transporter	Rattus norvegicus (Norway rat)	EC50	51.0000	1	1

Other Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
5-hydroxytryptamine receptor 2A	Homo sapiens (human)	Activity	0.0003	1	1
Adenosine receptor A1	Homo sapiens (human)	Affinity constant	30.0000	1	1
Adenosine receptor A1	Rattus norvegicus (Norway rat)	Kb	60.0000	1	4
Adenosine receptor A1	Homo sapiens (human)	KD hydro	150,000.0000	1	1
Adenosine receptor A2a	Homo sapiens (human)	Affinity constant	30.0000	1	1
Adenosine receptor A2a	Rattus norvegicus (Norway rat)	Kb	36.0000	1	1
Adenosine receptor A2a	Rattus norvegicus (Norway rat)	Ratio	48.0000	1	2
Adenosine receptor A2b	Homo sapiens (human)	Affinity constant	30.0000	1	1
Adenosine receptor A2b	Mus musculus (house mouse)	Kb	25.0000	1	1
Adenosine receptor A2b	Rattus norvegicus (Norway rat)	Ratio	48.0000	1	2
Adenylate cyclase type 1	Homo sapiens (human)	Kb	30.0000	1	1
ATP-dependent translocase ABCB1	Homo sapiens (human)	Km	12.4000	1	1
D(2) dopamine receptor	Homo sapiens (human)	Activity	0.0097	1	1
D(2) dopamine receptor	Rattus norvegicus (Norway rat)	K 0.5	0.0002	2	2
D(3) dopamine receptor	Rattus norvegicus (Norway rat)	K 0.5	0.0004	1	1
Delta-type opioid receptor	Mus musculus (house mouse)	K0.5	26.0000	1	2
Glutamate receptor ionotropic, NMDA 2C	Rattus norvegicus (Norway rat)	K0.5	0.2500	1	1
Histamine H1 receptor	Homo sapiens (human)	Activity	0.0430	1	1
Histamine H2 receptor	Cavia porcellus (domestic guinea pig)	K0.5	0.2720	1	2
Kappa-type opioid receptor	Mus musculus (house mouse)	K0.5	26.0000	1	2
Mu-type opioid receptor	Mus musculus (house mouse)	K0.5	26.0000	1	2
Muscarinic acetylcholine receptor	Cavia porcellus (domestic guinea pig)	Kb	25.0000	1	1
Muscarinic acetylcholine receptor M1	Mus musculus (house mouse)	K0.5	30.0000	1	2
Muscarinic acetylcholine receptor M2	Mus musculus (house mouse)	K0.5	30.0000	1	2
Muscarinic acetylcholine receptor M3	Mus musculus (house mouse)	K0.5	30.0000	1	2
Muscarinic acetylcholine receptor M4	Mus musculus (house mouse)	K0.5	30.0000	1	2
Muscarinic acetylcholine receptor M5	Mus musculus (house mouse)	K0.5	30.0000	1	2
Neuronal acetylcholine receptor subunit alpha-10	Rattus norvegicus (Norway rat)	K app	0.0062	1	3
Neuronal acetylcholine receptor subunit alpha-2	Rattus norvegicus (Norway rat)	K app	0.0062	1	3
Neuronal acetylcholine receptor subunit alpha-3	Rattus norvegicus (Norway rat)	K app	0.0062	1	3
Neuronal acetylcholine receptor subunit alpha-4	Rattus norvegicus (Norway rat)	K app	0.0062	1	3
Neuronal acetylcholine receptor subunit alpha-5	Rattus norvegicus (Norway rat)	K app	0.0062	1	3
Neuronal acetylcholine receptor subunit alpha-6	Rattus norvegicus (Norway rat)	K app	0.0062	1	3
Neuronal acetylcholine receptor subunit alpha-7	Rattus norvegicus (Norway rat)	K app	0.0062	1	3
Neuronal acetylcholine receptor subunit alpha-9	Rattus norvegicus (Norway rat)	K app	0.0062	1	3
Neuronal acetylcholine receptor subunit beta-2	Rattus norvegicus (Norway rat)	K app	0.0062	1	3
Neuronal acetylcholine receptor subunit beta-3	Rattus norvegicus (Norway rat)	K app	0.0062	1	3
Neuronal acetylcholine receptor subunit beta-4	Rattus norvegicus (Norway rat)	K app	0.0062	1	3
Solute carrier family 22 member 1	Homo sapiens (human)	Activity	53.2000	1	1
Transporter	Rattus norvegicus (Norway rat)	K app	0.0062	1	1
UDP-glucuronosyltransferase 1-6	Homo sapiens (human)	Km	3,200.0000	1	1
UDP-glucuronosyltransferase 1A9	Homo sapiens (human)	Km	5,200.0000	1	1
UDP-glucuronosyltransferase 2B7	Homo sapiens (human)	Km	2,100.0000	1	1
Vasopressin V2 receptor	Sus scrofa (pig)	Kb	30.0000	1	1