Compounds > 7-hydroxycoumarin-3-carboxylic acid
Page last updated: 2024-11-11

7-hydroxycoumarin-3-carboxylic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID5337757
CHEMBL ID104261
SCHEMBL ID37883
MeSH IDM0278316

Synonyms (42)

Synonym
CBMICRO_006719
c10h6o5
OPREA1_196511
nsc115545
779-27-1
nsc-115545
BIM-0006588.P001
7-hydroxy-2-oxochromene-3-carboxylic acid
7-hydroxy-2-oxo-2h-1-benzopyran-3-carboxylic acid
OPREA1_130366
7-hydroxycoumarin-3-carboxylic acid, suitable for fluorescence, >=98.0% (tlc)
MLS003151715
smr001856304
HMS1622I11
CHEMBL104261
AKOS001775416
umbelliferone-3-carboxylic acid
H1352
7-hydroxycoumarin-3-carboxylic acid
2h-1-benzopyran-3-carboxylic acid, 7-hydroxy-2-oxo-
nsc 115545
3-carboxy-7-hydroxycoumarin
CB09022
smsf0004210
F1018-0183
6-hydroxy-2-oxo-2h-1-benzopyran-3-carboxylic acid
FT-0621431
7-hydroxy-2-oxo-2h-chromene-3-carboxylic acid
SCHEMBL37883
7X-0812
DTXSID20228527
J-100177
3-carboxyumbelliferone
SR-01000461429-1
sr-01000461429
mfcd00017491
STL512106
AMY5156
A865119
SY055309
CS-0010024
PD167410
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Guanine nucleotide-binding protein GHomo sapiens (human)Potency50.11871.995325.532750.1187AID624287
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (5)

Processvia Protein(s)Taxonomy
negative regulation of inflammatory response to antigenic stimulusGuanine nucleotide-binding protein GHomo sapiens (human)
renal water homeostasisGuanine nucleotide-binding protein GHomo sapiens (human)
G protein-coupled receptor signaling pathwayGuanine nucleotide-binding protein GHomo sapiens (human)
regulation of insulin secretionGuanine nucleotide-binding protein GHomo sapiens (human)
cellular response to glucagon stimulusGuanine nucleotide-binding protein GHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (2)

Processvia Protein(s)Taxonomy
G protein activityGuanine nucleotide-binding protein GHomo sapiens (human)
adenylate cyclase activator activityGuanine nucleotide-binding protein GHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (1)

Processvia Protein(s)Taxonomy
plasma membraneGuanine nucleotide-binding protein GHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (44)

Assay IDTitleYearJournalArticle
AID1182961Antioxidant activity assessed as reaction rate at time zero for ABTS+ scavenging activity at 20 uM after 10 to 30 mins2014European journal of medicinal chemistry, Sep-12, Volume: 84Design and synthesis of coumarin-3-acylamino derivatives to scavenge radicals and to protect DNA.
AID1182962Antioxidant activity assessed as rate constant for ABTS+ scavenging activity at 20 uM after 10 to 30 mins2014European journal of medicinal chemistry, Sep-12, Volume: 84Design and synthesis of coumarin-3-acylamino derivatives to scavenge radicals and to protect DNA.
AID1168505Cytotoxicity against human HepG2 cells by MTT assay2014Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
Synthesis and biological evaluation of a novel class of coumarin derivatives.
AID1168516Neurotoxicity in mouse S180 cells allografted mouse assessed as induction of death at 1 umol/kg, ip for 7 consecutive days2014Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
Synthesis and biological evaluation of a novel class of coumarin derivatives.
AID1168512Neurotoxicity in mouse S180 cells allografted mouse assessed as induction of twitches at 1 umol/kg, ip for 7 consecutive days2014Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
Synthesis and biological evaluation of a novel class of coumarin derivatives.
AID503238Activity of Streptomyces antibioticus OleD A242V mutant assessed as as rate of glucoside formation measured as nanomoles of product formed per minute per mg of enzyme2007Nature chemical biology, Oct, Volume: 3, Issue:10
Expanding the promiscuity of a natural-product glycosyltransferase by directed evolution.
AID1168515Neurotoxicity in mouse S180 cells allografted mouse assessed as induction of supination at 1 umol/kg, ip for 7 consecutive days2014Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
Synthesis and biological evaluation of a novel class of coumarin derivatives.
AID1168511Neurotoxicity in mouse S180 cells allografted mouse assessed as induction of tremors at 1 umol/kg, ip for 7 consecutive days2014Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
Synthesis and biological evaluation of a novel class of coumarin derivatives.
AID1168525Toxicity in mouse S180 cells allografted mouse assessed as liver weight at 1 umol/kg, ip for 7 consecutive days measured 24 hrs after last dose (Rvb = 1.84 +/- 0.32 g)2014Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
Synthesis and biological evaluation of a novel class of coumarin derivatives.
AID1182959Antioxidant activity assessed as protection against Cu2+/GSH-induced DNA oxidation at 150 uM up to 180 mins by TBARS method2014European journal of medicinal chemistry, Sep-12, Volume: 84Design and synthesis of coumarin-3-acylamino derivatives to scavenge radicals and to protect DNA.
AID1168509Cytotoxicity against human A549 cells by MTT assay2014Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
Synthesis and biological evaluation of a novel class of coumarin derivatives.
AID1168510Antitumor activity against mouse S180 cells allografted in mouse assessed as tumor growth inhibition at 1 umol/kg, ip for 7 consecutive days2014Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
Synthesis and biological evaluation of a novel class of coumarin derivatives.
AID1182958Antioxidant activity assessed as inhibition time period for protection against AAPH-induced DNA oxidation at 37 degC by TBARS method2014European journal of medicinal chemistry, Sep-12, Volume: 84Design and synthesis of coumarin-3-acylamino derivatives to scavenge radicals and to protect DNA.
AID25853Photostability, pKa was evaluated1998Bioorganic & medicinal chemistry letters, Nov-17, Volume: 8, Issue:22
Synthesis of novel fluorinated coumarins: excellent UV-light excitable fluorescent dyes.
AID1182960Antioxidant activity assessed as OH-induced DNA oxidation at 150 uM by TBARS method2014European journal of medicinal chemistry, Sep-12, Volume: 84Design and synthesis of coumarin-3-acylamino derivatives to scavenge radicals and to protect DNA.
AID1168524Toxicity in mouse S180 cells allografted mouse assessed as heart weight at 1 umol/kg, ip for 7 consecutive days measured 24 hrs after last dose (Rvb = 0.12 +/- 0.02 g)2014Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
Synthesis and biological evaluation of a novel class of coumarin derivatives.
AID1168527Toxicity in mouse S180 cells allografted mouse assessed as spleen index at 1 umol/kg, ip for 7 consecutive days measured 24 hrs after last dose (Rvb = 7.25 +/- 1.60 No_unit)2014Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
Synthesis and biological evaluation of a novel class of coumarin derivatives.
AID503235Activity at Streptomyces antibioticus wild-type OleD assessed as as rate of glucoside formation measured as nanomoles of product formed per minute per mg of enzyme2007Nature chemical biology, Oct, Volume: 3, Issue:10
Expanding the promiscuity of a natural-product glycosyltransferase by directed evolution.
AID503237Activity of Streptomyces antibioticus OleD S123F mutant assessed as as rate of glucoside formation measured as nanomoles of product formed per minute per mg of enzyme2007Nature chemical biology, Oct, Volume: 3, Issue:10
Expanding the promiscuity of a natural-product glycosyltransferase by directed evolution.
AID1168513Neurotoxicity in mouse S180 cells allografted mouse assessed as induction of jumping behaviors at 1 umol/kg, ip for 7 consecutive days2014Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
Synthesis and biological evaluation of a novel class of coumarin derivatives.
AID1168506Cytotoxicity against human K562 cells by MTT assay2014Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
Synthesis and biological evaluation of a novel class of coumarin derivatives.
AID1168514Neurotoxicity in mouse S180 cells allografted mouse assessed as induction of tetanus behaviors at 1 umol/kg, ip for 7 consecutive days2014Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
Synthesis and biological evaluation of a novel class of coumarin derivatives.
AID1328524Gastroprotective activity in Swiss albino mouse assessed as reduction in HCl/EtOH-induced gastric lesions at 20 mg/kg, po pretreated for 50 mins followed by HCl/EtOH challenge measured after 1 hr2016Bioorganic & medicinal chemistry letters, 12-01, Volume: 26, Issue:23
Gastroprotective activity of synthetic coumarins: Role of endogenous prostaglandins, nitric oxide, non-protein sulfhydryls and vanilloid receptors.
AID503239Activity of Streptomyces antibioticus OleD P67T/S132F/A242V mutant assessed as as rate of glucoside formation measured as nanomoles of product formed per minute per mg of enzyme2007Nature chemical biology, Oct, Volume: 3, Issue:10
Expanding the promiscuity of a natural-product glycosyltransferase by directed evolution.
AID503236Activity of Streptomyces antibioticus OleD P67T mutant assessed as as rate of glucoside formation measured as nanomoles of product formed per minute per mg of enzyme2007Nature chemical biology, Oct, Volume: 3, Issue:10
Expanding the promiscuity of a natural-product glycosyltransferase by directed evolution.
AID1168507Cytotoxicity against human A172 cells by MTT assay2014Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
Synthesis and biological evaluation of a novel class of coumarin derivatives.
AID1168523Toxicity in mouse S180 cells allografted mouse assessed as brain weight at 1 umol/kg, ip for 7 consecutive days measured 24 hrs after last dose (Rvb = 0.30 +/- 0.02 g)2014Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
Synthesis and biological evaluation of a novel class of coumarin derivatives.
AID1168508Cytotoxicity against human Bel7402 cells by MTT assay2014Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
Synthesis and biological evaluation of a novel class of coumarin derivatives.
AID1168526Toxicity in mouse S180 cells allografted mouse assessed as kidney weight at 1 umol/kg, ip for 7 consecutive days measured 24 hrs after last dose (Rvb = 0.16 +/- 0.04 g)2014Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
Synthesis and biological evaluation of a novel class of coumarin derivatives.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).2014Journal of biomolecular screening, Jul, Volume: 19, Issue:6
A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (21)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's6 (28.57)18.2507
2000's3 (14.29)29.6817
2010's9 (42.86)24.3611
2020's3 (14.29)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 24.81

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index24.81 (24.57)
Research Supply Index3.09 (2.92)
Research Growth Index4.56 (4.65)
Search Engine Demand Index26.67 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (24.81)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other21 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
phosphoric acid
phosphoric acid: concise etchant is 37% H3PO4. phosphoric acid : A phosphorus oxoacid that consists of one oxo and three hydroxy groups joined covalently to a central phosphorus atom.		1.9910phosphoric acidsalgal metabolite;
fertilizer;
human metabolite;
NMR chemical shift reference compound;
solvent
erythrosine
Fluoresceins: A family of spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays.		210
indomethacin
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.		2.1310aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole		analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic
lansoprazole
Lansoprazole: A 2,2,2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a racemic mixture of (R)- and (S)-isomers.		2.1310benzimidazoles;
pyridines;
sulfoxide		anti-ulcer drug;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor
ethylmaleimide
Ethylmaleimide: A sulfhydryl reagent that is widely used in experimental biochemical studies.		2.1310maleimidesanticoronaviral agent;
EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor;
EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor;
EC 2.7.1.1 (hexokinase) inhibitor
hydrazine
diamine : Any polyamine that contains two amino groups.		210azane;
hydrazines		EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor
coumarin-3-carboxylic acid
coumarin-3-carboxylic acid: structure given in first source		2.4320coumarins
ferrous sulfate
ferrous sulfate: Ferro-Gradumet is ferrous sulfate in controlled release form; RN given refers to Fe(+2)[1:1] salt. iron(2+) sulfate (anhydrous) : A compound of iron and sulfate in which the ratio of iron(2+) to sulfate ions is 1:1. Various hydrates occur naturally - most commonly the heptahydrate, which loses water to form the tetrahydrate at 57degreeC and the monohydrate at 65degreeC.		1.9910iron molecular entity;
metal sulfate		reducing agent
ng-nitroarginine methyl ester
NG-Nitroarginine Methyl Ester: A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.		2.1310alpha-amino acid ester;
L-arginine derivative;
methyl ester;
N-nitro compound		EC 1.14.13.39 (nitric oxide synthase) inhibitor
oleandomycin
[no description available]		2.0310oleandomycins
3-acetylcoumarin
3-acetylcoumarin: structure given in first source. 3-acetylcoumarin : A member of the class of coumarins that is coumarin in which the hydrogen at position 3 is replaced by an acetyl group.		2.1310coumarins
ferric bleomycin
iron bleomycin: iron-bleomycin complexes		210
hydroxyl radical
Hydroxyl Radical: The univalent radical OH. Hydroxyl radical is a potent oxidizing agent.		2.420oxygen hydride;
oxygen radical;
reactive oxygen species
biotin
vitamin B7 : Any member of a group of vitamers that belong to the chemical structural class called biotins that exhibit biological activity against vitamin B7 deficiency. Vitamin B7 deficiency is very rare in individuals who take a normal balanced diet. Foods rich in biotin are egg yolk, liver, cereals, vegetables (spinach, mushrooms) and rice. Symptoms associated with vitamin B7 deficiency include thinning hair, scaly skin rashes around eyes, nose and mouth, and brittle nails. The vitamers include biotin and its ionized and salt forms.		210biotins;
vitamin B7		coenzyme;
cofactor;
Escherichia coli metabolite;
fundamental metabolite;
human metabolite;
mouse metabolite;
nutraceutical;
prosthetic group;
Saccharomyces cerevisiae metabolite
doxorubicin hydrochloride
[no description available]		2.110anthracycline
carbenoxolone
[no description available]		2.1310
trans-4-coumaric acid
hydroxycinnamic acid : Any member of the class of cinnamic acids carrying one or more hydroxy substituents.. trans-4-coumaric acid : The trans-isomer of 4-coumaric acid.. 4-coumaric acid : A coumaric acid in which the hydroxy substituent is located at C-4 of the phenyl ring.		2.05104-coumaric acidfood component;
mouse metabolite;
plant metabolite
scopoletin
[no description available]		2.1310hydroxycoumarinplant growth regulator;
plant metabolite
hymecromone
Hymecromone: A coumarin derivative possessing properties as a spasmolytic, choleretic and light-protective agent. It is also used in ANALYTICAL CHEMISTRY TECHNIQUES for the determination of NITRIC ACID.		2.7330hydroxycoumarinantineoplastic agent;
hyaluronic acid synthesis inhibitor
kaempferol
[no description available]		2.03107-hydroxyflavonol;
flavonols;
tetrahydroxyflavone		antibacterial agent;
geroprotector;
human blood serum metabolite;
human urinary metabolite;
human xenobiotic metabolite;
plant metabolite
genistein
[no description available]		2.03107-hydroxyisoflavonesantineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor
esculetin
esculetin: used in filters for absorption of ultraviolet light; structure. esculetin : A hydroxycoumarin that is umbelliferone in which the hydrogen at position 6 is substituted by a hydroxy group. It is used in filters for absorption of ultraviolet light.		2.1310hydroxycoumarinantioxidant;
plant metabolite;
ultraviolet filter
7-hydroxycoumarin
7-oxycoumarin: derivatives have anti-oxidant properties. umbelliferone : A hydroxycoumarin that is coumarin substituted by a hydroxy group ay position 7.		2.1110hydroxycoumarinfluorescent probe;
food component;
plant metabolite
daidzein
[no description available]		2.03107-hydroxyisoflavonesantineoplastic agent;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
phytoestrogen;
plant metabolite
7-hydroxycoumarin-4-acetic acid
7-hydroxycoumarin-4-acetic acid: pH-indicator dye; structure in first source		2.4720
5,7-dihydroxy-4-methylcoumarin
[no description available]		2.1310hydroxycoumarin
7-hydroxy-4-trifluoromethylcoumarin
7-hydroxy-4-trifluoromethylcoumarin: structure given in first source		1.9910
cysteine
Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.		2.0510cysteiniumfundamental metabolite
ascorbic acid
Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.		210ascorbic acid;
vitamin C		coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent
warfarin
Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.		1.9910benzenes;
hydroxycoumarin;
methyl ketone
concanavalin a
Concanavalin A: A MANNOSE/GLUCOSE binding lectin isolated from the jack bean (Canavalia ensiformis). It is a potent mitogen used to stimulate cell proliferation in lymphocytes, primarily T-lymphocyte, cultures.		210
ConditionIndicatedRelationship StrengthStudiesTrials
Innate Inflammatory Response
[description not available]		02.0510
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		02.0510
Encephalitis, Polio
[description not available]		02.0610
Poliomyelitis
An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)		02.0610
Plasmodium falciparum Malaria
[description not available]		02.110
Malaria, Falciparum
Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.		02.110
Benign Neoplasms
[description not available]		02.110
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.110
Gastric Ulcer
[description not available]		02.1310
Stomach Ulcer
Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).		02.1310