An agonist that binds to and deactivates the tropomyosin-related kinase B (TrkB) receptor, the main signaling receptor of the neurotrophin brain-derived neurotrophic factor (BDNF).
ChEBI ID: 140489
| Member | Definition | Class |
|---|---|---|
| 7,8-dihydroxyflavone | A dihydroxyflavone that is flavone substituted by hydroxy groups at positions 7 and 8. A dihydroxyflavone that is flavone substituted by hydroxy groups at positions 7 and 8. A naturally occurring flavonoid produced by several plants, including the weed Tridax procumbens (coalbuttons or tridax daisy) and the tree Godmania aesculifolia, In animal models, it has shown efficacy against several diseases of the nervous system, including Alzheimer's, Parkinson's, and Huntington's. | 7,8-dihydroxyflavone |
| amitriptyline | An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5. | amitriptyline |
| diosmetin | A monomethoxyflavone that is the 4'-methyl ether derivative of luteolin. It is a natural product isolated from citrus fruits which exhibits a range of pharmacological activities. | diosmetin |
| n-acetylserotonin | An N-acylserotonin resulting from the formal condensation of the primary amino group of serotonin with the carboxy group of acetic acid. | N-acetylserotonin |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 3,522 (50.90) | 18.7374 |
| 1990's | 1,040 (15.03) | 18.2507 |
| 2000's | 954 (13.79) | 29.6817 |
| 2010's | 1,072 (15.49) | 24.3611 |
| 2020's | 332 (4.80) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 1,381 (18.34%) | 5.53% |
| Reviews | 417 (5.54%) | 6.00% |
| Case Studies | 872 (11.58%) | 4.05% |
| Observational | 13 (0.17%) | 0.25% |
| Other | 4,845 (64.36%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 7.1912 | 1 | 2 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| 67.9K protein | Vaccinia virus | Potency | 27.0050 | 2 | 2 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 21.8959 | 1 | 2 |
| arylsulfatase A | Homo sapiens (human) | Potency | 3.0131 | 1 | 1 |
| Ataxin-2 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 13.0918 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 0.0032 | 2 | 2 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 12.5893 | 2 | 2 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 21.8456 | 1 | 3 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 8.9716 | 2 | 2 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 9.1063 | 1 | 2 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 6.1904 | 1 | 2 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 8.9716 | 2 | 2 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 9.5221 | 1 | 1 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 21.2010 | 1 | 3 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 24.2910 | 2 | 6 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 15.0916 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 0.6906 | 2 | 2 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 14.6892 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 29.8493 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 5.6697 | 1 | 2 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 10.6579 | 4 | 4 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 24.2910 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 24.2910 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 24.2910 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 24.2910 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 24.2910 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 24.2910 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 24.2910 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 24.2910 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 24.2910 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 24.2910 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 24.2910 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 24.2910 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 24.2910 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 24.2910 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 24.2910 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 24.2910 | 1 | 3 |
| geminin | Homo sapiens (human) | Potency | 0.1946 | 2 | 2 |
| GLS protein | Homo sapiens (human) | Potency | 3.5305 | 2 | 3 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 18.9389 | 1 | 6 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 11.7086 | 1 | 3 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 33.2058 | 2 | 3 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 2.5119 | 1 | 1 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 0.1749 | 2 | 2 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 5.0119 | 2 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 1.9331 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 22.7406 | 2 | 2 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 18.9389 | 1 | 3 |
| PPM1D protein | Homo sapiens (human) | Potency | 11.7086 | 1 | 2 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 14.6892 | 2 | 2 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 19.8496 | 2 | 3 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 24.6880 | 1 | 2 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 48.0224 | 1 | 2 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 22.4786 | 5 | 5 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 | 1.0200 | 2 | 2 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Ki | 1.1410 | 1 | 1 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | IC50 | 1.0200 | 2 | 2 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | Ki | 1.1410 | 1 | 1 |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | IC50 | 0.0440 | 1 | 1 |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | IC50 | 0.0440 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | IC50 | 0.0150 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | IC50 | 0.0440 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 0.0044 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 0.0700 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | IC50 | 0.0440 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 0.0450 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | IC50 | 0.0060 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | IC50 | 0.0440 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 0.0032 | 1 | 1 |
| 5-hydroxytryptamine receptor 3A | Rattus norvegicus (Norway rat) | IC50 | 0.0440 | 1 | 1 |
| 5-hydroxytryptamine receptor 3B | Rattus norvegicus (Norway rat) | IC50 | 0.0440 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | IC50 | 0.0060 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | Ki | 0.0032 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Rattus norvegicus (Norway rat) | IC50 | 0.0440 | 1 | 1 |
| 5-hydroxytryptamine receptor 5A | Rattus norvegicus (Norway rat) | IC50 | 0.0440 | 1 | 1 |
| 5-hydroxytryptamine receptor 5B | Rattus norvegicus (Norway rat) | IC50 | 0.0440 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | IC50 | 0.1400 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Rattus norvegicus (Norway rat) | IC50 | 0.0440 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Ki | 0.0650 | 1 | 1 |
| 5-hydroxytryptamine receptor 7 | Cavia porcellus (domestic guinea pig) | IC50 | 16.9000 | 1 | 2 |
| 5-hydroxytryptamine receptor 7 | Rattus norvegicus (Norway rat) | IC50 | 0.0440 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 0.0230 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 0.0220 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0000 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | IC50 | 0.1050 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | Ki | 0.0520 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 0.1755 | 2 | 2 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 0.1320 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | IC50 | 0.0040 | 2 | 2 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 0.0037 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | IC50 | 0.0295 | 2 | 2 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | Ki | 0.0086 | 1 | 1 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | IC50 | 17.5894 | 1 | 1 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | Ki | 14.4106 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Aurora kinase B | Homo sapiens (human) | IC50 | 3.8600 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 134.0000 | 2 | 2 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 91.5000 | 2 | 2 |
| Cytochrome P450 1A1 | Homo sapiens (human) | IC50 | 0.1400 | 1 | 1 |
| Cytochrome P450 1A1 | Homo sapiens (human) | Ki | 0.0890 | 1 | 1 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 2.4370 | 1 | 1 |
| Cytochrome P450 1B1 | Homo sapiens (human) | IC50 | 0.0290 | 1 | 1 |
| Cytochrome P450 1B1 | Homo sapiens (human) | Ki | 0.0160 | 2 | 2 |
| D(1A) dopamine receptor | Homo sapiens (human) | IC50 | 0.3550 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | Ki | 0.1335 | 2 | 2 |
| D(1B) dopamine receptor | Homo sapiens (human) | Ki | 0.1700 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | IC50 | 1.0090 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | Ki | 0.2660 | 2 | 2 |
| D(3) dopamine receptor | Homo sapiens (human) | IC50 | 0.1820 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 0.1340 | 2 | 2 |
| High affinity nerve growth factor receptor | Homo sapiens (human) | IC50 | 60.0000 | 1 | 1 |
| Histamine H1 receptor | Homo sapiens (human) | IC50 | 0.0048 | 1 | 1 |
| Histamine H1 receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0000 | 1 | 2 |
| Histamine H1 receptor | Homo sapiens (human) | Ki | 0.0008 | 2 | 2 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | IC50 | 0.6600 | 1 | 1 |
| Histamine H2 receptor | Homo sapiens (human) | IC50 | 0.7300 | 1 | 1 |
| Histamine H2 receptor | Homo sapiens (human) | Ki | 0.7180 | 1 | 1 |
| Histamine H3 receptor | Homo sapiens (human) | Ki | 1.0000 | 1 | 1 |
| Inhibitor of nuclear factor kappa-B kinase subunit beta | Homo sapiens (human) | IC50 | 9.8200 | 1 | 1 |
| Inositol hexakisphosphate kinase 2 | Homo sapiens (human) | IC50 | 0.9000 | 1 | 1 |
| Inositol polyphosphate multikinase | Homo sapiens (human) | IC50 | 7.2000 | 1 | 1 |
| large T antigen | Betapolyomavirus macacae | IC50 | 21.6700 | 1 | 1 |
| Lysine-specific histone demethylase 1A | Homo sapiens (human) | IC50 | 27.9000 | 1 | 1 |
| Mitogen-activated protein kinase 10 | Homo sapiens (human) | IC50 | 25.9000 | 1 | 2 |
| Mitogen-activated protein kinase 14 | Homo sapiens (human) | IC50 | 25.9000 | 1 | 2 |
| Multidrug resistance-associated protein 1 | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | IC50 | 0.0110 | 1 | 1 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | IC50 | 0.3000 | 1 | 4 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | Ki | 0.0027 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | IC50 | 0.0810 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | IC50 | 0.3000 | 1 | 3 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | Ki | 0.0290 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | IC50 | 0.0260 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | IC50 | 0.3000 | 1 | 3 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | Ki | 0.0054 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | IC50 | 0.0053 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | IC50 | 0.3000 | 1 | 3 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | Ki | 0.0007 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | IC50 | 0.0080 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | IC50 | 0.3000 | 1 | 3 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | Ki | 0.0058 | 1 | 1 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | IC50 | 17.5894 | 1 | 1 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | Ki | 14.4106 | 1 | 1 |
| Palmitoleoyl-protein carboxylesterase NOTUM | Homo sapiens (human) | IC50 | 93.6000 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 7.9835 | 14 | 14 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | Ki | 14.4106 | 1 | 1 |
| Ribosyldihydronicotinamide dehydrogenase [quinone] | Homo sapiens (human) | IC50 | 9.9000 | 1 | 1 |
| Sepiapterin reductase | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | IC50 | 1.0310 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | Ki | 0.4330 | 1 | 1 |
| Sodium channel protein type 1 subunit alpha | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| Sodium channel protein type 10 subunit alpha | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| Sodium channel protein type 11 subunit alpha | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| Sodium channel protein type 2 subunit alpha | Homo sapiens (human) | IC50 | 11.5500 | 2 | 2 |
| Sodium channel protein type 3 subunit alpha | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| Sodium channel protein type 4 subunit alpha | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| Sodium channel protein type 5 subunit alpha | Homo sapiens (human) | IC50 | 10.8000 | 2 | 2 |
| Sodium channel protein type 7 subunit alpha | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| Sodium channel protein type 8 subunit alpha | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| Sodium channel protein type 9 subunit alpha | Homo sapiens (human) | IC50 | 9.3333 | 3 | 3 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 12.5892 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 6.2030 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 1.0324 | 2 | 2 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 0.1775 | 2 | 2 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 0.2756 | 2 | 2 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | Ki | 0.0284 | 5 | 6 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | IC50 | 16.9000 | 1 | 1 |
| Telomerase reverse transcriptase | Homo sapiens (human) | IC50 | 36.0000 | 1 | 1 |
| Tyrosinase | Mus musculus (house mouse) | IC50 | 311.0000 | 1 | 1 |
| Tyrosinase | Mus musculus (house mouse) | Ki | 240.0000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Homo sapiens (human) | IC50 | 11.6000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1D | Homo sapiens (human) | IC50 | 11.6000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1F | Homo sapiens (human) | IC50 | 11.6000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1S | Homo sapiens (human) | IC50 | 11.6000 | 1 | 1 |
| Voltage-dependent N-type calcium channel subunit alpha-1B | Homo sapiens (human) | IC50 | 12.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Albumin | Rattus norvegicus (Norway rat) | Kd | 134.0000 | 1 | 1 |
| BDNF/NT-3 growth factors receptor | Homo sapiens (human) | Kd | 0.1650 | 2 | 2 |
| High affinity nerve growth factor receptor | Homo sapiens (human) | EC50 | 86.0000 | 1 | 1 |
| High affinity nerve growth factor receptor | Homo sapiens (human) | Kd | 2,050.0000 | 4 | 4 |
| Sigma non-opioid intracellular receptor 1 | Cavia porcellus (domestic guinea pig) | EC50 | 86.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Catechol O-methyltransferase | Rattus norvegicus (Norway rat) | Km | 3.2400 | 2 | 2 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | K0.5 | 0.0005 | 1 | 2 |
| UDP-glucuronosyltransferase 1A3 | Homo sapiens (human) | Km | 267.0000 | 1 | 1 |
| UDP-glucuronosyltransferase 1A4 | Homo sapiens (human) | Km | 110.0000 | 2 | 3 |