Page last updated: 2024-09-27

Aphakia

Absence of crystalline lens totally or partially from field of vision, from any cause except after cataract extraction. Aphakia is mainly congenital or as result of LENS DISLOCATION AND SUBLUXATION.

Synonyms(4)

Synonym
Aphakic Eye
Aphakia
Aphakic Eye, Post-traumatic
Aphakic Eye, Traumatic

Research Excerpts

Overview

ExcerptReference
"Posttraumatic aphakia is a serious deterrent to visual rehabilitation that usually follows sensory exotropia, thereby mandating urgent surgical intervention."( Agarwal, R; Bafna, RK; Tiwari, K; Yadav, N, 2020)

Context

ExcerptReference
"The mutant aphakia has been characterised by bilaterally aphakic eyes (Varnum and Stevens, J Hered 1968;59:147-50); the corresponding gene was mapped to chromosome 19 (Varnum and Stevens, Mouse News Lett 1975;53:35)."( Graw, J, 1999)

Treatment

ExcerptReference
"PGE levels, higher in placebo-treated aphakic eyes than in phakic ones, were elevated further by epinephrine treatment (from 388."( Hikita, M; Kuratomi, R; Miyake, K; Miyake, Y; Shirasawa, E, 1988)
"Hence, the surgical treatment of aphakia still remains controversial and challenging."( Avitabile, T; Choragiewicz, T; Figus, M; Forlini, M; Gagliano, C; Jünemann, AGM; Kaminska, A; Longo, A; Nowomiejska, K; Posarelli, C; Reibaldi, M; Rejdak, R; Toro, MD; Tripodi, S, 2019)
"The simultaneous treatment of aphakia and aniridia with a single prosthesis, the stability of the Reper and the functional, anatomical and aesthetic outcomes obtained are the highlighted advantages in this study."( De Biasi, CS; Frisina, R; Gambato, C; Gius, I; Londei, D; Midena, E; Tozzi, L, 2021)
"Despite prior documentation of aphakia after treatment for congenital cataracts, detailed workup revealed residual crystalline lens material pushing the peripheral iris anteriorly."( Lyons, LJ; Roddy, GW; Wu, KY, 2022)

Research

Studies (182)

TimeframeStudies, This Condition (%)All Conditions %
pre-199067 (36.81)23.3326
1990's36 (19.78)12.5806
2000's27 (14.84)18.1394
2010's36 (19.78)28.8240
2020's16 (8.79)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0low10
3,4-dihydroxyphenylacetic acid0low10
glycerol0low10
hydrogen carbonate0medium21
amlodipine0low10
amphetamine0low10
erythrosine0low20
fluorouracil0medium61
gentamicin0low30
indomethacin0low20
2-propanol0medium661
methoxsalen0low10
oxidopamine0low20
sulpiride0low10
tolmetin0medium11
mitomycin0medium21
prednisolone0low10
carbachol0low10
pilocarpine0low20
physostigmine0low10
apomorphine0low10
bromodeoxyuridine0low20
galactose0low20
levodopa0low50
cytarabine0low10
ornithine0low10
perflutren0low20
triamcinolone acetonide0low10
tromethamine0medium11
n-vinyl-2-pyrrolidinone0low30
ergotamine0low10
echothiophate iodide0low20
aminoacetonitrile0low10
hydroxyethyl methacrylate0low10
fluorescein0low10
neodymium0low10
argon0low10
holmium0medium11
yttrium0low10
phenyl acetate0medium21
cefazolin0low20
timolol0low20
amikacin0low20
ketorolac tromethamine0medium11
nicotine0low10
interleukin-1beta (163-171)0low10
perfilcon a0low20
atropine0low20
5'-o-(9-phenylxanthen-9-yl)-2'-deoxynebularine0low10
cortisone0low10
fibrin0low10
retinol0low10
enkephalin, leucine0low10
bromochloroacetic acid0low10
retinaldehyde0low10
stilbenes0low10
D-fructopyranose0low10
6-ketoprostaglandin f1 alpha0low10
amphotericin b0low10
thromboxane b20low10
fosbretabulin0low10
enalapril0low10
cefotaxime0low20
dizocilpine maleate0low10
sl 3270low10
cefmenoxime0low10
alpha-synuclein0low10
dynorphins0low10
ro13-99040low10
ascorbic acid0low10
oxytetracycline, anhydrous0low10
transforming growth factor beta0low10
eye0medium371
preproenkephalin0low10

Protein Targets (791)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
hypoxia-inducible factor 1 alpha subunit120012
RAR-related orphan receptor gamma230023
GLI family zinc finger 3220022
AR protein280028
aldehyde dehydrogenase 1 family, member A1140014
retinoic acid nuclear receptor alpha variant 1220022
retinoid X nuclear receptor alpha170017
estrogen nuclear receptor alpha280028
peroxisome proliferator-activated receptor delta140014
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a130013
activating transcription factor 67007
v-jun sarcoma virus 17 oncogene homolog (avian)100010
Histone H2A.x8008
thyroid hormone receptor beta isoform a110011
heat shock protein beta-18008
nuclear factor erythroid 2-related factor 2 isoform 1200020
lamin isoform A-delta10180018
Voltage-dependent calcium channel gamma-2 subunit140014
Glutamate receptor 2150015
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE140014
Chain A, TYROSYL-DNA PHOSPHODIESTERASE9009
Chain A, HADH2 protein6006
Chain B, HADH2 protein6006
Chain A, JmjC domain-containing histone demethylation protein 3A4004
Chain A, 2-oxoglutarate Oxygenase8008
Chain A, Protocatechuate 3,4-dioxygenase0011
Chain M, Protocatechuate 3,4-dioxygenase0011
Olfactory receptor class A-like protein 10011
Luciferase120012
endonuclease IV5005
thioredoxin reductase150015
RGS121001
phosphopantetheinyl transferase120012
NFKB1 protein, partial2002
GLS protein110011
TDP1 protein180018
Microtubule-associated protein tau110011
Thrombopoietin2002
alkaline phosphatase, intestinal0011
thioredoxin glutathione reductase5005
apical membrane antigen 1, AMA14004
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)6006
thyroid stimulating hormone receptor6006
hypothetical protein, conserved2002
regulator of G-protein signaling 4100010
euchromatic histone-lysine N-methyltransferase 2200020
Bloom syndrome protein isoform 1110011
lysosomal alpha-glucosidase preproprotein2002
peripheral myelin protein 22 isoform 14004
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein0101
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
intestinal alkaline phosphatase precursor0101
chromobox protein homolog 1170017
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 11001
DNA polymerase beta3003
flap endonuclease 15005
DNA polymerase iota isoform a (long)8008
geminin200020
M-phase phosphoprotein 86006
alkaline phosphatase, germ cell type preproprotein0011
POsterior Segregation0011
muscarinic acetylcholine receptor M15005
Prolyl 4-hydroxylase subunit alpha-10101
Sodium-dependent noradrenaline transporter 0011
Zinc finger protein mex-50011
ATP-dependent phosphofructokinase110011
Solute carrier organic anion transporter family member 2A10002
peripheral myelin protein 22120012
histone acetyltransferase KAT2A isoform 1120012
ATP-binding cassette sub-family C member 3015015
Multidrug resistance-associated protein 4015016
Bile salt export pump018018
Canalicular multispecific organic anion transporter 1015015
Aminoglycoside 3'-phosphotransferase 0001
Chain A, Ferritin light chain5005
acid sphingomyelinase1001
Smad33003
cytochrome P450 family 3 subfamily A polypeptide 4150015
G8008
cytochrome P450 2D6120012
IDH19009
NEDD8-activating enzyme E1 regulatory subunit isoform a0101
NEDD8-conjugating enzyme Ubc120101
nuclear receptor ROR-gamma isoform 18008
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Potassium channel subfamily K member 20112
Interferon beta9009
HLA class I histocompatibility antigen, B alpha chain 8008
ATP-dependent translocase ABCB10303
Alpha-2A adrenergic receptor0606
Alpha-2C adrenergic receptor0404
Alpha-2B adrenergic receptor0202
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Alpha-2C adrenergic receptor0202
Alpha-2A adrenergic receptor0202
Alpha-1D adrenergic receptor0505
Alpha-1A adrenergic receptor0101
Alpha-1B adrenergic receptor0101
5-hydroxytryptamine receptor 60404
Spike glycoprotein9009
Sodium-dependent dopamine transporter 0202
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Potassium channel subfamily K member 2 0101
Inositol hexakisphosphate kinase 18008
cytochrome P450 2C9, partial8008
Solute carrier family 22 member 30101
5-hydroxytryptamine receptor 2C0213
Phenylethanolamine N-methyltransferase0202
Cytochrome P450 2A60538
Substance-P receptor0101
5-hydroxytryptamine receptor 2A0213
5-hydroxytryptamine receptor 1A09211
Cytochrome P450 2A50202
Sodium-dependent dopamine transporter0404
5-hydroxytryptamine receptor 1B0819
5-hydroxytryptamine receptor 1D0213
5-hydroxytryptamine receptor 1F0213
5-hydroxytryptamine receptor 2B0213
5-hydroxytryptamine receptor 60112
5-hydroxytryptamine receptor 7 0213
5-hydroxytryptamine receptor 5A0112
5-hydroxytryptamine receptor 5B0112
5-hydroxytryptamine receptor 3A0112
Sigma non-opioid intracellular receptor 10112
5-hydroxytryptamine receptor 4 0112
Beta-2 adrenergic receptor0112
5-hydroxytryptamine receptor 3B0112
Sigma non-opioid intracellular receptor 10101
Chain A, Cruzipain4004
interleukin 87007
glucocorticoid receptor [Homo sapiens]210021
farnesoid X nuclear receptor120012
vitamin D (1,25- dihydroxyvitamin D3) receptor140014
tumor necrosis factor1001
vitamin D3 receptor isoform VDRA9009
Cytochrome P450 1A20314
Cytochrome P450 3A40415
Cytochrome P450 2D60314
Cytochrome P450 2C9 0314
Cytochrome P450 2C190112
Nuclear receptor ROR-gamma81110
Potassium voltage-gated channel subfamily H member 20303
Aurora kinase B0101
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Chain A, Putative fructose-1,6-bisphosphate aldolase7007
acetylcholinesterase110011
estrogen receptor 2 (ER beta)100010
nuclear receptor subfamily 1, group I, member 3140014
progesterone receptor120012
estrogen-related nuclear receptor alpha170017
peroxisome proliferator activated receptor gamma100010
aryl hydrocarbon receptor170017
thyroid stimulating hormone receptor8008
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a7007
cytochrome P450 2D6 isoform 14004
cellular tumor antigen p53 isoform a3003
cytochrome P450 2C19 precursor3003
cytochrome P450 2C9 precursor3003
potassium voltage-gated channel subfamily H member 2 isoform d5005
thyroid hormone receptor beta isoform 2160016
mitogen-activated protein kinase 14004
cytochrome P450 3A4 isoform 19009
lethal factor (plasmid)4004
Gamma-aminobutyric acid receptor subunit pi92112
Solute carrier family 22 member 1 0203
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Cellular tumor antigen p53160016
Integrin beta-32002
Integrin alpha-IIb2002
5-hydroxytryptamine receptor 1A0101
Tryptophan 5-hydroxylase 10101
D(2) dopamine receptor06312
Gamma-aminobutyric acid receptor subunit beta-192112
Alpha-1B adrenergic receptor0404
Gamma-aminobutyric acid receptor subunit delta92112
Gamma-aminobutyric acid receptor subunit gamma-292213
D0303
D(3) dopamine receptor0202
Gamma-aminobutyric acid receptor subunit alpha-592112
Gamma-aminobutyric acid receptor subunit alpha-392112
D(2) dopamine receptor0202
D(1A) dopamine receptor0428
D(4) dopamine receptor0315
D(1B) dopamine receptor0203
Gamma-aminobutyric acid receptor subunit gamma-192112
Gamma-aminobutyric acid receptor subunit alpha-292112
Alpha-1D adrenergic receptor0303
D(1B) dopamine receptor0202
5-hydroxytryptamine receptor 2A0303
Gamma-aminobutyric acid receptor subunit alpha-492112
Gamma-aminobutyric acid receptor subunit gamma-392112
Gamma-aminobutyric acid receptor subunit alpha-692112
D(4) dopamine receptor0213
D(3) dopamine receptor06211
Alpha-1A adrenergic receptor0404
Histamine H2 receptor4005
5-hydroxytryptamine receptor 70202
D(2) dopamine receptor0426
Gamma-aminobutyric acid receptor subunit alpha-192213
Gamma-aminobutyric acid receptor subunit beta-392112
Gamma-aminobutyric acid receptor subunit beta-292213
E3 ubiquitin-protein ligase Mdm20202
D0101
GABA theta subunit92112
D0202
ATPase family AAA domain-containing protein 57007
Ataxin-28008
Sigma non-opioid intracellular receptor 10303
Gamma-aminobutyric acid receptor subunit epsilon92112
Chain A, Hyaluronidase, phage associated0101
nuclear factor erythroid 2-related factor 2 isoform 29009
lethal(3)malignant brain tumor-like protein 1 isoform I2002
Polyphenol oxidase 20113
Pancreatic alpha-amylase0202
Albumin0101
Urease0101
Prolyl 4-hydroxylase subunit alpha-10001
Tyrosinase0202
Alpha-2B adrenergic receptor0213
Hyaluronate lyase0101
Prolyl hydroxylase EGLN20001
Egl nine homolog 10001
Prolyl hydroxylase EGLN30001
Hypoxia-inducible factor 1-alpha inhibitor0001
Solute carrier family 23 member 10101
pregnane X nuclear receptor170017
cystic fibrosis transmembrane conductance regulator0101
short transient receptor potential channel 6 isoform 10011
5-hydroxytryptamine receptor 40404
Muscarinic acetylcholine receptor M205413
Muscarinic acetylcholine receptor M404310
Muscarinic acetylcholine receptor M107214
Muscarinic acetylcholine receptor M307213
Muscarinic acetylcholine receptor M408113
Muscarinic acetylcholine receptor M507112
Muscarinic acetylcholine receptor M505311
Muscarinic acetylcholine receptor M208114
Muscarinic acetylcholine receptor M105514
Muscarinic acetylcholine receptor M10124
Muscarinic acetylcholine receptor M304310
5-hydroxytryptamine receptor 2C0404
Muscarinic acetylcholine receptor M40202
Reverse transcriptase/RNaseH 0001
Muscarinic acetylcholine receptor0314
pregnane X receptor7007
nuclear receptor subfamily 1, group I, member 25005
galanin receptor type 30101
Glucocorticoid receptor08114
Glycine receptor subunit alpha-10808
Glycine receptor subunit beta0808
Glycine receptor subunit alpha-20808
Glycine receptor subunit alpha-30808
ORF730011
ATAD5 protein, partial6006
bromodomain adjacent to zinc finger domain 2B6006
arylsulfatase A9009
Nuclear hormone receptor family member daf-120011
serine/threonine-protein kinase mTOR isoform 14004
oxysterols receptor LXR-beta isoform 10011
urokinase-type plasminogen activator precursor3003
plasminogen precursor3003
urokinase plasminogen activator surface receptor precursor3003
survival motor neuron protein isoform d5005
Thymidine kinase, cytosolic0202
Thymidine phosphorylase0001
Thymidylate kinase0101
Thymidine kinase0001
Thymidylate kinase0101
Chain A, Beta-lactamase5005
GALC protein1001
thyrotropin-releasing hormone receptor4004
Neuronal acetylcholine receptor subunit alpha-30326
Neuronal acetylcholine receptor subunit alpha-41428
Neuronal acetylcholine receptor subunit alpha-20326
Neuronal acetylcholine receptor subunit beta-21428
Neuronal acetylcholine receptor subunit beta-30326
Neuronal acetylcholine receptor subunit beta-40326
Neuronal acetylcholine receptor subunit alpha-50326
Delta-type opioid receptor0518
Neuronal acetylcholine receptor subunit alpha-60326
Neuronal acetylcholine receptor subunit alpha-90326
Neuronal acetylcholine receptor subunit alpha-70326
Muscarinic acetylcholine receptor M30013
Muscarinic acetylcholine receptor M20003
Neuronal acetylcholine receptor subunit alpha-100326
peptidyl-prolyl cis-trans isomerase NIMA-interacting 15005
Solute carrier family 22 member 60303
Solute carrier family 15 member 10404
Solute carrier family 22 member 60303
Solute carrier family 22 member 80303
Solute carrier family 22 member 110202
Solute carrier family 22 member 80202
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0101
Beta-lactamase 0001
Metallo-beta-lactamase type 20001
Metallo-beta-lactamase VIM-11 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-19 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase0001
Beta-lactamase 0101
Albumin0224
Beta-lactamase SHV-10001
Beta-lactamase SHV-10001
Beta-lactamase0001
Kappa-type opioid receptor0102
B2 metallo-beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Solute carrier family 15 member 20101
Metallo-beta-lactamase VIM-130001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase 0001
Beta-lactamase Toho-10001
Beta-lactamase 0001
Solute carrier family 22 member 70102
Metallo-beta-lactamase0001
Solute carrier family 15 member 20101
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-b-lactamase 0001
BlaVIM-1 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Carbapenem-hydrolyzing beta-lactamase KPC0001
Histamine H3 receptor0001
Beta-lactamase class B VIM-2 0001
Beta-lactamase VIM-1 0001
Solute carrier family 22 member 70101
dopamine D1 receptor2002
atrial natriuretic peptide receptor 1 precursor3003
Sex hormone-binding globulin0011
Corticosteroid-binding globulin0202
Potassium voltage-gated channel subfamily A member 10011
TAR DNA-binding protein 435005
Multidrug and toxin extrusion protein 10303
glp-1 receptor, partial3003
USP1 protein, partial6006
EWS/FLI fusion protein7007
67.9K protein5005
LMP1 [Human herpesvirus 4]0002
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
transactivating tegument protein VP16 [Human herpesvirus 1]0101
nuclear receptor coactivator 3 isoform a0101
Thymidine kinase 2, mitochondrial0101
Thymidine kinase0101
Thymidylate synthase0102
Thymidine kinase0101
Deoxycytidine kinase0001
Probable deoxycytidylate deaminase0001
Cytidine deaminase0102
D(1A) dopamine receptor1001
Enoyl-[acyl-carrier-protein] reductase [NADH] 0101
Thymidine kinase0101
Deoxynucleoside kinase0101
Glutamate receptor ionotropic, NMDA 1 0102
Glutamate receptor ionotropic, NMDA 2A 0102
Glutamate receptor ionotropic, NMDA 2B0102
Glutamate receptor ionotropic, NMDA 2C0102
Glutamate receptor ionotropic, NMDA 2D0102
Glutamate receptor ionotropic, NMDA 3B0102
Glutamate receptor ionotropic, NMDA 3A0102
Mas-related G-protein coupled receptor member X20011
Angiotensin-converting enzyme 0101
Angiotensin-converting enzyme0101
Type-2 angiotensin II receptor0101
Succinyl-diaminopimelate desuccinylase0101
Solute carrier organic anion transporter family member 1A10001
Angiotensin-converting enzyme0101
Solute carrier family 15 member 10101
Angiotensin-converting enzyme 2 0101
Opioid receptor, delta 1b 0101
Opioid receptor homologue0101
Proenkephalin-B0011
Delta-type opioid receptor0303
Kappa-type opioid receptor0101
Mu-type opioid receptor0303
Kappa-type opioid receptor0101
Mu-type opioid receptor0213
Delta-type opioid receptor0112
Kappa-type opioid receptor0112
Mu-type opioid receptor0101
Mu-type opioid receptor0404
Mu-type opioid receptor0101
Adenylate cyclase 0101
Tyrosine-protein kinase Lck0202
Tyrosine-protein kinase Fyn0202
ATP-dependent translocase ABCB10101
Beta-2 adrenergic receptor0606
Beta-1 adrenergic receptor0606
ATP-dependent translocase ABCB10101
Thromboxane-A synthase 0202
5-hydroxytryptamine receptor 1D0101
5-hydroxytryptamine receptor 1B0101
5-hydroxytryptamine receptor 2B0404
5-hydroxytryptamine receptor 5A0101
Chain A, ATP-DEPENDENT DNA HELICASE Q16006
Genome polyprotein 0112
chaperonin-containing TCP-1 beta subunit homolog1001
SMAD family member 27007
Fumarate hydratase2002
SMAD family member 37007
polyprotein2002
ubiquitin carboxyl-terminal hydrolase 2 isoform a4004
eyes absent homolog 2 isoform a1001
DNA polymerase kappa isoform 1100010
relaxin receptor 1 isoform 11001
Flavin reductase (NADPH)0011
large T antigen0101
Chain A, Uracil Phosphoribosyltransferase0101
Skn7p0001
nonstructural protein 13003
hemoglobin subunit beta1001
huntingtin isoform 22002
Vpr1001
muscleblind-like protein 1 isoform 12002
Solute carrier family 22 member 80001
Epidermal growth factor receptor0303
Amyloid-beta precursor protein1304
Aromatase0101
HSP40, subfamily A [Plasmodium falciparum 3D7]0001
importin subunit beta-1 isoform 13003
snurportin-13003
Beta-galactosidase0101
Lipopolysaccharide heptosyltransferase 10101
PA-I galactophilic lectin0011
Jacalin0011
Gamma-aminobutyric acid 0011
Gamma-aminobutyric acid receptor subunit rho-30011
Hsf1 protein0011
D(1A) dopamine receptor3003
transcriptional regulator ERG isoform 32002
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
neuropeptide S receptor isoform A2002
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Histone deacetylase 30101
Gamma-aminobutyric acid type B receptor subunit 20011
Gamma-aminobutyric acid type B receptor subunit 20101
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit alpha-60011
Gamma-aminobutyric acid receptor subunit beta-10112
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit gamma-20011
Gamma-aminobutyric acid receptor subunit delta0011
Sodium- and chloride-dependent GABA transporter 10202
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit gamma-30011
Gamma-aminobutyric acid receptor subunit beta-30112
Gamma-aminobutyric acid receptor subunit rho-20011
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0101
Gamma-aminobutyric acid receptor subunit alpha-50112
Sodium- and chloride-dependent GABA transporter 20202
Sodium- and chloride-dependent GABA transporter 30202
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-30112
Gamma-aminobutyric acid receptor subunit alpha-20112
Gamma-aminobutyric acid receptor subunit beta-20112
Sodium- and chloride-dependent betaine transporter0202
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-40112
Gamma-aminobutyric acid receptor subunit beta-10011
Histone deacetylase 40101
Gamma-aminobutyric acid receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit beta-30011
Gamma-aminobutyric acid receptor subunit epsilon0101
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
Histone deacetylase 10101
Gamma-aminobutyric acid receptor subunit alpha-60112
Sterol O-acyltransferase 10011
Proton-coupled amino acid transporter 10101
Gamma-aminobutyric acid receptor subunit alpha-50011
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit pi0011
Histone deacetylase 70101
Histone deacetylase 20101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
Gamma-aminobutyric acid receptor subunit gamma-30101
Histone deacetylase 80101
Gamma-aminobutyric acid receptor subunit alpha-40011
Platelet glycoprotein VI0011
Gamma-aminobutyric acid receptor subunit theta0011
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid receptor subunit gamma-10011
Histone deacetylase 60101
Gamma-aminobutyric acid type B receptor subunit 10011
Histone deacetylase 90101
Gamma-aminobutyric acid receptor subunit theta0101
Histone deacetylase 50101
Gamma-aminobutyric acid type B receptor subunit 10101
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E0011
Carbonic anhydrase 10305
Carbonic anhydrase 20305
Carbonic anhydrase 40102
Carbonic anhydrase0102
Carbonic anhydrase 150203
Chain A, membrane-associated prostaglandin E synthase-20101
glucocerebrosidase1001
Parkin3003
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
ras-related protein Rab-9A1001
Prostaglandin-H2 D-isomerase0101
Prostaglandin E synthase0101
Prostaglandin G/H synthase 1 0102
Prostaglandin G/H synthase 2 0102
3',5'-cyclic-AMP phosphodiesterase 0101
Solute carrier organic anion transporter family member 2B1 0202
Cytochrome c oxidase subunit 20101
Phospholipase A2, major isoenzyme0101
Prostaglandin G/H synthase 10203
Procathepsin L0101
Interleukin-80202
Androgen receptor0213
Polyunsaturated fatty acid 5-lipoxygenase0102
Aldo-keto reductase family 1 member B10102
Aldo-keto reductase family 1 member B10101
Aldo-keto reductase family 1 member C40101
Prostaglandin G/H synthase 10101
Prostaglandin G/H synthase 10202
Adenosine receptor A10102
Serum paraoxonase/arylesterase 10202
Indoleamine 2,3-dioxygenase 10202
Caspase-10001
Nitric oxide synthase, inducible0101
Adenosine receptor A2a0102
Substance-P receptor0101
Prostaglandin E2 receptor EP3 subtype0101
Prostaglandin E2 receptor EP4 subtype0101
Multidrug resistance-associated protein 1 0101
Bifunctional epoxide hydrolase 20101
Prostaglandin G/H synthase 20415
Prostaglandin G/H synthase 2 0101
Prostaglandin E2 receptor EP1 subtype0101
Peroxisome proliferator-activated receptor gamma0011
Aldo-keto reductase family 1 member C30202
C-X-C chemokine receptor type 30101
Aldo-keto reductase family 1 member C2 0101
Guanine nucleotide-binding protein G2002
Prostaglandin D2 receptor 0202
Solute carrier organic anion transporter family member 1A30101
Prostaglandin G/H synthase 20202
Lactoylglutathione lyase0202
Aldo-keto reductase family 1 member C10101
Prostaglandin G/H synthase 20102
Uracil nucleotide/cysteinyl leukotriene receptor0101
Sigma intracellular receptor 20101
Prostaglandin E2 receptor EP2 subtype0101
Rho-associated protein kinase 20101
Prostaglandin G/H synthase 1 0101
Nicotinate phosphoribosyltransferase0101
Dehydrogenase/reductase SDR family member 90101
P2Y purinoceptor 120101
Solute carrier organic anion transporter family member 1B30202
Cytosolic phospholipase A2 gamma0101
Prostaglandin D2 receptor 20112
Solute carrier organic anion transporter family member 1B10202
histone deacetylase 9 isoform 32002
Beta-3 adrenergic receptor0404
Sodium-dependent serotonin transporter0202
15-lipoxygenase, partial4004
WRN2002
integrase, partial0101
lens epithelium-derived growth factor p750101
pyruvate kinase1001
hexokinase-4 isoform 12002
glucokinase regulatory protein2002
DNA polymerase eta isoform 12002
Carbonic anhydrase 120102
Plasma kallikrein0001
Carbonic anhydrase 30102
Polyunsaturated fatty acid lipoxygenase ALOX150101
Carbonic anhydrase 60102
Carbonic anhydrase 5A, mitochondrial0102
Carbonic anhydrase 70102
Carbonic anhydrase0102
Large neutral amino acids transporter small subunit 10101
SLC16A10 protein0001
Carbonic anhydrase 90103
Carbonic anhydrase 0102
Carbonic anhydrase-like protein, putative0001
Carbonic anhydrase0001
Carbonic anhydrase0102
Carbonic anhydrase 0102
Monocarboxylate transporter 100001
Carbonic anhydrase 130001
Carbonic anhydrase 140001
Carbonic anhydrase 5B, mitochondrial0102
phosphoglycerate kinase2002
Amine oxidase [flavin-containing] A0101
Acetylcholinesterase0203
Beta-secretase 10101
Cytochrome P450 2A130336
caspase 7, apoptosis-related cysteine protease2002
caspase-32002
Indoleamine 2,3-dioxygenase 10101
5-hydroxytryptamine receptor 3E0101
Neuronal acetylcholine receptor subunit alpha-40213
Transient receptor potential cation channel subfamily A member 10011
5-hydroxytryptamine receptor 3B0101
Acetylcholine receptor subunit alpha0213
Acetylcholine receptor subunit alpha0213
Acetylcholine receptor subunit beta0213
Acetylcholine receptor subunit gamma0213
Acetylcholine receptor subunit delta0213
Acetylcholine receptor subunit gamma0213
Neuronal acetylcholine receptor subunit alpha-40101
Acetylcholine receptor subunit beta0213
Translocator protein0101
Neuronal acetylcholine receptor subunit beta-20213
Acetylcholine receptor subunit beta-like 20202
Neuronal acetylcholine receptor subunit alpha-50011
Neuronal acetylcholine receptor subunit beta-40213
Neuronal acetylcholine receptor subunit alpha-30213
Neuronal acetylcholine receptor subunit alpha-70224
Neuronal acetylcholine receptor subunit alpha-40213
5-hydroxytryptamine receptor 3A0101
Neuronal acetylcholine receptor subunit alpha-70202
Acetylcholine-binding protein0112
Inositol monophosphatase 11001
Acetylcholine receptor subunit epsilon0011
Neuronal acetylcholine receptor subunit beta-30112
Acetylcholine receptor subunit delta0213
Neuronal acetylcholine receptor subunit alpha-20101
Neuronal acetylcholine receptor subunit alpha-60112
Neuronal acetylcholine receptor subunit alpha-50202
Liver carboxylesterase B-10101
Solute carrier family 22 member 10101
5-hydroxytryptamine receptor 3D0101
Transient receptor potential cation channel subfamily A member 10011
Neuronal acetylcholine receptor subunit beta-30202
Neuronal acetylcholine receptor subunit beta-40202
Neuronal acetylcholine receptor subunit alpha-30202
Soluble acetylcholine receptor0101
5-hydroxytryptamine receptor 3C0101
Neuronal acetylcholine receptor subunit alpha-20202
Neuronal acetylcholine receptor subunit beta-20213
Solute carrier family 22 member 20101
Neuronal acetylcholine receptor subunit alpha-60202
Integrin beta0011
Glycoprotein IIb0011
Transporter0214
Chain A, ARGINASE 10101
Chain A, Arginase 10101
Chain A, ARGINASE 10101
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain A, L-ARGININE\\:GLYCINE AMIDINOTRANSFERASE0101
runt-related transcription factor 1 isoform AML1b1001
core-binding factor subunit beta isoform 21001
Glyceraldehyde-3-phosphate dehydrogenase0101
Glutamate receptor 11001
Glutamate receptor 31001
Glutamate receptor 41001
DNA repair protein RAD52 homolog0101
Valosin-containing protein0101
microphthalmia-associated transcription factor isoform 90101
eukaryotic translation initiation factor 4 gamma 1 isoform 40101
serine/threonine-protein kinase PLK11001
eukaryotic translation initiation factor 4E isoform 10101
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
Rap guanine nucleotide exchange factor 31001
Acetylcholinesterase0203
Bile salt export pump0202
Acetylcholinesterase0101
Cholinesterase0202
Acetylcholinesterase0101
Acetylcholinesterase 0101
Acetylcholinesterase0101
Acetylcholinesterase0101
Cholinesterase0203
Cholinesterase0101
Acyl-CoA:cholesterol acyltransferase 0101
Carboxylic ester hydrolase 0101
Carboxylic ester hydrolase 0101
Muscarinic acetylcholine receptor DM10101
luciferase0001
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Mineralocorticoid receptor 0213
Glutamine synthetase0011
Androgen receptor0101
Histamine H1 receptor0011
Nociceptin receptor0011
Cytochrome P450 2J20202
Estrogen receptor beta0202
Chain A, Cellular retinoic acid-binding protein 20011
Chain A, Cellular retinoic acid-binding protein 20011
Caspase-72002
caspase-32002
Aldo-keto reductase family 1 member B100002
Alpha-synuclein0303
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR0011
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
Retinol-binding protein 40011
Beta-lactoglobulin0011
Disintegrin and metalloproteinase domain-containing protein 171001
epidermal growth factor receptor isoform a precursor0101
Transcription factor AP-10101
Mitogen-activated protein kinase 3 0101
Dual specificity mitogen-activated protein kinase kinase 20101
Dual specificity mitogen-activated protein kinase kinase 40101
Tyrosinase0101
NAD(P)H dehydrogenase [quinone] 10001
Carbonic anhydrase 0001
Carbonic anhydrase 0101
Carbonic anhydrase 0101
Carbonic anhydrase 0101
Carbonic anhydrase0101
Carbonic anhydrase0101
5-hydroxytryptamine receptor 70101
Beta-carbonic anhydrase 10101
Carbonic anhydrase 20101
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase 0101
Delta carbonic anhydrase0101
Carbonic anhydrase 40101
D(2) dopamine receptor0101
Solute carrier organic anion transporter family member 2A10001
Beta-1 adrenergic receptor 0011
Beta-1 adrenergic receptor0101
Chain A, Nuclear Receptor ROR-beta0101
Ornithine decarboxylase0001
Ornithine decarboxylase0001
60 kDa chaperonin0101
Adenosine receptor A30202
Retinoic acid receptor alpha0227
60 kDa heat shock protein, mitochondrial0101
Retinoic acid receptor beta0227
Retinoic acid receptor alpha0123
Retinoic acid receptor gamma 0227
Alpha-1A adrenergic receptor0101
Retinoic acid receptor gamma0123
Retinoic acid receptor RXR-alpha0224
Retinoic acid receptor beta0123
Cellular retinoic acid-binding protein 20011
Mitogen-activated protein kinase 10101
Retinoic acid receptor RXR-alpha0123
Retinoic acid receptor RXR-beta0224
Retinoic acid receptor RXR-beta0123
Retinoic acid receptor RXR-gamma0123
Nuclear receptor ROR-alpha0101
Cellular retinoic acid-binding protein 10102
Retinoic acid receptor RXR-gamma0224
10 kDa heat shock protein, mitochondrial0101
Cellular retinoic acid-binding protein 10011
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10213
Thiosulfate sulfurtransferase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Indoleamine 2,3-dioxygenase 20101
Nuclear receptor ROR-beta0101
Chain A, CARBONIC ANHYDRASE II0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]