Page last updated: 2024-12-08

2,5-dimethyl-3,6-diaziridinyl-1,4-benzoquinone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2,5-dimethyl-3,6-diaziridinyl-1,4-benzoquinone: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID159854
CHEMBL ID311910
SCHEMBL ID1614158
MeSH IDM0199211

Synonyms (13)

Synonym
NCI60_016124
2,6-diaziridinyl-1,4-benzoquinone
nsc-646714
nsc646714
medzq
NEURO_000349
2,5-dimethyl-3,6-diaziridinyl-1,4-benzoquinone
18735-47-2
CHEMBL311910
2,5-bis(aziridin-1-yl)-3,6-dimethylcyclohexa-2,5-diene-1,4-dione
2,5-cyclohexadiene-1,4-dione, 2,5-bis(1-aziridinyl)-3,6-dimethyl-
SCHEMBL1614158
DTXSID10172045
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (17)

Assay IDTitleYearJournalArticle
AID157787Ability to produce interstrand cross-links in the plasmid DNA at 100 uM concentration1999Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
Cross-linking and sequence-specific alkylation of DNA by aziridinylquinones. 3. Effects of alkyl substituents.
AID57693Rate of reduction by human recombinant DTD1999Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
Cross-linking and sequence-specific alkylation of DNA by aziridinylquinones. 3. Effects of alkyl substituents.
AID1130141Antileukemic activity against mouse L1210 cells allografted in BDF1 mouse assessed as concentration required to give maximum increase in life span administered as qd for 12 days1979Journal of medicinal chemistry, May, Volume: 22, Issue:5
Quantitative structure-activity relationships in 2,5-bis(1-aziridinyl)-p-benzoquinone derivatives against leukemia L-1210.
AID85942In vitro cytotoxicity against HT-29 cell line1999Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
Cross-linking and sequence-specific alkylation of DNA by aziridinylquinones. 3. Effects of alkyl substituents.
AID1130142Antileukemic activity against mouse L1210 cells allografted in BDF1 mouse assessed as concentration required to increase 40% life span administered for 1 day1979Journal of medicinal chemistry, May, Volume: 22, Issue:5
Quantitative structure-activity relationships in 2,5-bis(1-aziridinyl)-p-benzoquinone derivatives against leukemia L-1210.
AID133615Optimal Dose (OD) which cause maximum increase in the life span, after chronic injection at log (1/C).1990Journal of medicinal chemistry, Sep, Volume: 33, Issue:9
Neural networks applied to quantitative structure-activity relationship analysis.
AID133616Optimal Dose (OD) which cause maximum increase in the life span, after singular injection at log (1/C).1990Journal of medicinal chemistry, Sep, Volume: 33, Issue:9
Neural networks applied to quantitative structure-activity relationship analysis.
AID94809In vitro cytotoxicity tested against human chronic leukemia K562 cells1997Journal of medicinal chemistry, Jan-31, Volume: 40, Issue:3
Cross-linking and sequence specific alkylation of DNA by aziridinyl quinones. 2. Structure requirements for sequence selectivity.
AID41356In vitro cytotoxicity against BE cell line1999Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
Cross-linking and sequence-specific alkylation of DNA by aziridinylquinones. 3. Effects of alkyl substituents.
AID1130140Antileukemic activity against mouse L1210 cells allografted in BDF1 mouse assessed as concentration required to increase 40% life span administered as qd for 12 days1979Journal of medicinal chemistry, May, Volume: 22, Issue:5
Quantitative structure-activity relationships in 2,5-bis(1-aziridinyl)-p-benzoquinone derivatives against leukemia L-1210.
AID78400In vitro cytotoxicity against H460 cell line1999Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
Cross-linking and sequence-specific alkylation of DNA by aziridinylquinones. 3. Effects of alkyl substituents.
AID41243Rate of reduction by human BE cell extract1999Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
Cross-linking and sequence-specific alkylation of DNA by aziridinylquinones. 3. Effects of alkyl substituents.
AID78558In vitro cytotoxicity against H596 cell line1999Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
Cross-linking and sequence-specific alkylation of DNA by aziridinylquinones. 3. Effects of alkyl substituents.
AID132974Minimum Effective Dose (MED) which cause 40% increase in life span, after singular injection at log (1/C).1990Journal of medicinal chemistry, Sep, Volume: 33, Issue:9
Neural networks applied to quantitative structure-activity relationship analysis.
AID132973Minimum Effective Dose (MED) which cause 40% increase in life span, after chronic injection at log (1/C).1990Journal of medicinal chemistry, Sep, Volume: 33, Issue:9
Neural networks applied to quantitative structure-activity relationship analysis.
AID1130143Antileukemic activity against mouse L1210 cells allografted in BDF1 mouse assessed as concentration required to give maximum increase in life span administered for 1 day1979Journal of medicinal chemistry, May, Volume: 22, Issue:5
Quantitative structure-activity relationships in 2,5-bis(1-aziridinyl)-p-benzoquinone derivatives against leukemia L-1210.
AID157667Ability to produce interstrand cross-links in the plasmid DNA at 10 uM concentration1999Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
Cross-linking and sequence-specific alkylation of DNA by aziridinylquinones. 3. Effects of alkyl substituents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (14)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (7.14)18.7374
1990's12 (85.71)18.2507
2000's1 (7.14)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.83

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.83 (24.57)
Research Supply Index2.77 (2.92)
Research Growth Index5.60 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.83)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (13.33%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other13 (86.67%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]