trisulfapyrimidine profile

Trisulfapyrimidine is a sulfonamide antibiotic that was once used to treat bacterial infections. It is a combination of three sulfa drugs: sulfamerazine, sulfadiazine, and sulfamethazine. Trisulfapyrimidine is effective against a wide range of bacteria, including those that cause pneumonia, meningitis, and urinary tract infections. However, it has been largely replaced by newer, safer antibiotics. Trisulfapyrimidine can cause serious side effects, such as allergic reactions, blood disorders, and liver damage. It is still used in some countries to treat certain types of infections. However, it is important to note that trisulfapyrimidine is not recommended for use in pregnant women or breastfeeding mothers, as it can harm the fetus or infant.'

trisulfapyrimidine: RN given refers to above drug combination; RR:65567-91-1 refers to Na salt of each of the components; contains above 3 cpds [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	60896
MeSH ID	M0063702

Synonym
8017-57-0
triple sulfoid
lantrisul
sulfa-triple #2
sulfaloid
trisulfapyrimidine
trisulfa
benzenesulfonamide, 4-amino-n-(4,6-dimethyl-2-pyrimidinyl)-, mixt. with 4-amino-n-(4-methyl-2-pyrimidinyl)benzenesulfonamide and 4-amino-n-2-pyrimidinylbenzenesulfonamide
4-amino-n-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide, mixt. with 4-amino-n-(4-methyl-2-pyrimidinyl)benzenesulfonamide & 4-amino-n-2-pyrimidinylbenzenesulfonamide
DTXSID20230125
4-amino-n-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide;4-amino-n-(4-methylpyrimidin-2-yl)benzenesulfonamide;4-amino-n-pyrimidin-2-ylbenzenesulfonamide

Excerpt	Reference	Relevance
"The bioavailability of seven commercial trisulfapyrimidine suspensions was studied in 14 adult male volunteers."	( Bioavailability and dissolution behavior of trisulfapyrimidine suspensions. Barry, H; Colaizzi, JL; Goehl, TJ; Jaffe, JM; Mathur, LK; Poust, RI; Shah, VP, 1979)	0.79

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	16 (76.19)	18.7374
1990's	3 (14.29)	18.2507
2000's	1 (4.76)	29.6817
2010's	1 (4.76)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	3 (13.04%)	5.53%
Reviews	1 (4.35%)	6.00%
Case Studies	2 (8.70%)	4.05%
Observational	0 (0.00%)	0.25%
Other	17 (73.91%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
theophylline [no description available]	6.95	1	0	dimethylxanthine	adenosine receptor antagonist; anti-asthmatic drug; anti-inflammatory agent; bronchodilator agent; drug metabolite; EC 3.1.4.* (phosphoric diester hydrolase) inhibitor; fungal metabolite; human blood serum metabolite; immunomodulator; muscle relaxant; vasodilator agent
pyrimethamine Maloprim: contains above 2 cpds	4.01	4	0	aminopyrimidine; monochlorobenzenes	antimalarial; antiprotozoal drug; EC 1.5.1.3 (dihydrofolate reductase) inhibitor
sulfadiazine Sulfadiazine: One of the short-acting SULFONAMIDES used in combination with PYRIMETHAMINE to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections.. sulfadiazine : A sulfonamide consisting of pyrimidine with a 4-aminobenzenesulfonamido group at the 2-position.. diazine : The parent structure of the diazines.	12.4	21	2	pyrimidines; substituted aniline; sulfonamide antibiotic; sulfonamide	antiinfective agent; antimicrobial agent; antiprotozoal drug; coccidiostat; drug allergen; EC 1.1.1.153 [sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)] inhibitor; EC 2.5.1.15 (dihydropteroate synthase) inhibitor; environmental contaminant; xenobiotic
sulfamerazine [no description available]	12.4	21	2	pyrimidines; sulfonamide antibiotic; sulfonamide	antiinfective agent; drug allergen
sulfamethazine Sulfamethazine: A sulfanilamide anti-infective agent. It has a spectrum of antimicrobial action similar to other sulfonamides.. sulfamethazine : A sulfonamide consisting of pyrimidine with methyl substituents at the 4- and 6-positions and a 4-aminobenzenesulfonamido group at the 2-position.	12.4	21	2	pyrimidines; sulfonamide antibiotic; sulfonamide	antibacterial drug; antiinfective agent; antimicrobial agent; carcinogenic agent; drug allergen; EC 2.5.1.15 (dihydropteroate synthase) inhibitor; environmental contaminant; ligand; xenobiotic
sulfisomidine Sulfisomidine: A sulfanilamide antibacterial agent.. sulfisomidine : A sulfonamide consisting of pyrimidine having methyl substituents at the 2- and 6-positions and a 4-aminobenzenesulfonamido group at the 4-position.	1.93	1	0	pyrimidines; sulfonamide antibiotic; sulfonamide	antiinfective agent
sulfisoxazole Sulfisoxazole: A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms.. sulfisoxazole : A sulfonamide antibacterial with an oxazole substituent. It has antibiotic activity against a wide range of gram-negative and gram-positive organisms.	1.93	1	0	isoxazoles; sulfonamide antibiotic; sulfonamide	antibacterial drug; drug allergen
prednisone Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.. prednisone : A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid.	1.98	1	0	11-oxo steroid; 17alpha-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(1),Delta(4)-steroid; C21-steroid; glucocorticoid; primary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone	adrenergic agent; anti-inflammatory drug; antineoplastic agent; immunosuppressive agent; prodrug
penicillin g Penicillin G: A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.. benzylpenicillin : A penicillin in which the substituent at position 6 of the penam ring is a phenylacetamido group.	8.34	1	1	penicillin allergen; penicillin	antibacterial drug; drug allergen; epitope
troleandomycin Troleandomycin: A macrolide antibiotic that is similar to ERYTHROMYCIN.. troleandomycin : A semi-synthetic macrolide antibiotic obtained by acetylation of the three free hydroxy groups of oleandomycin. Troleandomycin is only found in individuals that have taken the drug.	1.93	1	0	acetate ester; epoxide; macrolide antibiotic; monosaccharide derivative; polyketide; semisynthetic derivative	EC 1.14.13.97 (taurochenodeoxycholate 6alpha-hydroxylase) inhibitor; xenobiotic
trimethoprim, sulfamethoxazole drug combination Trimethoprim, Sulfamethoxazole Drug Combination: A drug combination with broad-spectrum antibacterial activity against both gram-positive and gram-negative organisms. It is effective in the treatment of many infections, including PNEUMOCYSTIS PNEUMONIA in AIDS.. co-trimoxazole : A two-component mixture comprising trimethoprim and sulfamethoxazole.	3.23	1	0
clindamycin Clindamycin: An antibacterial agent that is a semisynthetic analog of LINCOMYCIN.. clindamycin : A carbohydrate-containing antibiotic that is the semisynthetic derivative of lincomycin, a natural antibiotic.	1.98	1	0
amphotericin b Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.. amphotericin B : A macrolide antibiotic used to treat potentially life-threatening fungal infections.	1.96	1	0	antibiotic antifungal drug; macrolide antibiotic; polyene antibiotic	antiamoebic agent; antiprotozoal drug; bacterial metabolite
ascorbic acid Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.	3.43	1	1	ascorbic acid; vitamin C	coenzyme; cofactor; flour treatment agent; food antioxidant; food colour retention agent; geroprotector; plant metabolite; skin lightening agent
tetracycline Tetracycline: A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.. tetracycline : A broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria.	3.03	5	0

Condition	Relationship Strength	Studies	Trials
Recrudescence [description not available]	3.34	2	0
Ocular Toxoplasmosis [description not available]	3.34	2	0
Chorioretinitis Inflammation of the choroid in which the sensory retina becomes edematous and opaque. The inflammatory cells and exudate may burst through the sensory retina to cloud the vitreous body.	3.04	1	0
Toxoplasmosis, Ocular Infection caused by the protozoan parasite TOXOPLASMA in which there is extensive connective tissue proliferation, the retina surrounding the lesions remains normal, and the ocular media remain clear. Chorioretinitis may be associated with all forms of toxoplasmosis, but is usually a late sequel of congenital toxoplasmosis. The severe ocular lesions in infants may lead to blindness.	3.34	2	0
Cervicitis [description not available]	3.43	1	1
Infections, Chlamydia [description not available]	3.43	1	1
Uterine Cervicitis Inflammation of the UTERINE CERVIX.	3.43	1	1
Chlamydia Infections Infections with bacteria of the genus CHLAMYDIA.	3.43	1	1
Dyspareunia Recurrent genital pain occurring during, before, or after SEXUAL INTERCOURSE in either the male or the female.	3.43	1	1
Vaginal Discharge A common gynecologic disorder characterized by an abnormal, nonbloody discharge from the genital tract.	3.43	1	1
Urinary Tract Infections Inflammatory responses of the epithelium of the URINARY TRACT to microbial invasions. They are often bacterial infections with associated BACTERIURIA and PYURIA.	2.34	2	0
Neisseria gonorrhoeae Infection [description not available]	1.93	1	0
Gonorrhea Acute infectious disease characterized by primary invasion of the urogenital tract. The etiologic agent, NEISSERIA GONORRHOEAE, was isolated by Neisser in 1879.	1.93	1	0
Infection [description not available]	2.34	2	0
Infections Invasion of the host organism by microorganisms or their toxins or by parasites that can cause pathological conditions or diseases.	2.34	2	0
Infections, Staphylococcal [description not available]	1.93	1	0
Group A Strep Infection [description not available]	1.93	1	0
Staphylococcal Infections Infections with bacteria of the genus STAPHYLOCOCCUS.	1.93	1	0
Streptococcal Infections Infections with bacteria of the genus STREPTOCOCCUS.	1.93	1	0
Disease, Pulmonary [description not available]	1.93	1	0
Lung Diseases Pathological processes involving any part of the LUNG.	1.93	1	0
Chronic Kidney Failure [description not available]	1.96	1	0
Infections, Mycobacterium [description not available]	1.96	1	0
Infectious Skin Diseases [description not available]	1.96	1	0
Kidney Failure, Chronic The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.	1.96	1	0
Mycobacterium Infections Infections with bacteria of the genus MYCOBACTERIUM.	1.96	1	0
Skin Diseases, Infectious Skin diseases caused by bacteria, fungi, parasites, or viruses.	1.96	1	0
Middle Ear Inflammation [description not available]	1.96	1	0
Middle Ear Effusion [description not available]	2.37	2	0
Otitis Media, Purulent [description not available]	1.96	1	0
Rupture, Spontaneous Tear or break of an organ, vessel or other soft part of the body, occurring in the absence of external force.	1.96	1	0
Otitis Media Inflammation of the MIDDLE EAR including the AUDITORY OSSICLES and the EUSTACHIAN TUBE.	1.96	1	0
Otitis Media with Effusion Inflammation of the middle ear with a clear pale yellow-colored transudate.	2.37	2	0
Otitis Media, Suppurative Inflammation of the middle ear with purulent discharge.	1.96	1	0
Habermann Disease [description not available]	1.99	1	0
Infection, Toxoplasma gondii [description not available]	2.67	3	0
Toxoplasmosis The acquired form of infection by Toxoplasma gondii in animals and man.	2.67	3	0
Infections, Respiratory [description not available]	3.34	1	1
Acute Disease Disease having a short and relatively severe course.	3.75	2	1
Respiratory Tract Infections Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.	8.34	1	1
Acquired Immune Deficiency Syndrome [description not available]	1.98	1	0
Acquired Immunodeficiency Syndrome An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms. Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by the CDC in 1993.	1.98	1	0
Blastomyces brasiliensis Infection [description not available]	1.96	1	0
Experimental Lung Inflammation Inflammation of any part, segment or lobe, of the lung parenchyma.	1.96	1	0
Pneumonia Infection of the lung often accompanied by inflammation.	1.96	1	0

trisulfapyrimidine

Description

Cross-References

Synonyms (11)

Research Excerpts

Bioavailability

Research

Studies (21)

Market Indicators

Research Demand Index: 30.41

Study Types