Roles > GABA reuptake inhibitor
Page last updated: 2024-08-05 15:21:34
GABA reuptake inhibitor
A compound that inhibits the re-uptake of the neurotransmitter GABA from the synapse into the pre-synaptic neuron, so increasing the extracellular concentrations of the neurotransmitter and hence increasing neurotransmission.
ChEBI ID: 85384
Members (3)
| Member | Definition | Class |
|---|
| guvacine | A alpha,beta-unsaturated monocarboxylic acid that is nicotinic acid which has been hydrogenated at the 1-2 and 5-6 positions of the pyridine ring. | guvacine |
| tiagabine | A piperidinemonocarboxylic acid that is (R)-nipecotic acid in which the hydrogen attached to the nitrogen has been replaced by a 1,1-bis(3-methyl-2-thienyl)but-1-en-4-yl group. A GABA reuptake inhibitor, it is used (generally as the hydrochloride salt) for the treatment of epilepsy. | tiagabine |
| tiagabine hydrochloride | A hydrochloride resulting from the reaction of equimolar amounts of tiagabine and hydrogen chloride. A GABA reuptake inhibitor, it is used for the treatment of epilepsy. | tiagabine hydrochloride |
Research
Studies (597)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|
| pre-1990 | 11 (1.84) | 18.7374 |
| 1990's | 168 (28.14) | 18.2507 |
| 2000's | 265 (44.39) | 29.6817 |
| 2010's | 126 (21.11) | 24.3611 |
| 2020's | 27 (4.52) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|
| Trials | 102 (15.81%) | 5.53% |
| Reviews | 110 (17.05%) | 6.00% |
| Case Studies | 56 (8.68%) | 4.05% |
| Observational | 1 (0.16%) | 0.25% |
| Other | 376 (58.29%) | 84.16% |
Protein Targets (24)
Potency Measurements
Inhibition Measurements
Activation Measurements
Other Measurements