A disorder of iron metabolism characterized by a triad of HEMOSIDEROSIS; LIVER CIRRHOSIS; and DIABETES MELLITUS. It is caused by massive iron deposits in parenchymal cells that may develop after a prolonged increase of iron absorption. (Jablonski's Dictionary of Syndromes & Eponymic Diseases, 2d ed)
| Excerpt | Reference |
|---|
| "Hemochromatosis is an iron storage disease in humans characterized by highly saturated transferrin levels and sometimes by diabetes." | ( Jenson, RL; Lim, TH; Sargent, T, 1979) |
| "Idiopathic hemochromatosis is a genetical defect leading to continuous accumulation of iron." | ( Fischer, R, 1976) |
| "Hemochromatosis is a disorder characterized by the association of portal cirrhosis with deposition of excess amounts of iron in the parenchymal cells of many organs." | ( Jensen, PS, 1976) |
| "Hemochromatosis is often not recognized until the patient presents with the symptoms of hepatocellular carcinoma and erythrocytosis, and the development of erythrocytosis is an important clue to the under-lying hepatoma." | ( Cooperberg, AA; Niloff, P; Raphael, B, 1979) |
| "Hemochromatosis is inherited as an autosomal-recessive disease, with partial biochemical expression in heterozygotes." | ( Amos, DB; Buskjaer, L; Cartwright, GE; Edwards, CQ; Johnson, A; Kravitz, K; Skolnick, M, 1979) |
| "Idiopathic hemochromatosis is an iron-storage disease more common in men than in women." | ( Afrooz, N; Sinclair, WP, 1977) |
| "Idiopathic hemochromatosis is frequently associated with various malignancies including hepatic carcinoma." | ( Akagi, K; Fujishima, M; Ishitsuka, T; Nomiyama, K; Okamura, T; Shibuya, T; Sugie, Y; Tsuji, H, 1992) |
| "Hemochromatosis is a human leukocyte antigen-linked (HLA-linked), potentially lethal disorder of iron metabolism with a high prevalence in white populations albeit an autosomal recessive mode of transmission." | ( da Silva, BM; de Sousa, M; Fraga, J; Porto, G; Vicente, C, 1992) |
| "Idiopathic hemochromatosis is a recessive autosomal disorder of iron metabolism manifested by a tissue overload affecting many organs, including the liver, the heart, the endocrine glands and the joints." | ( Aellen, P; Guerne, PA; Vischer, TL; Zenagui, D, 1992) |
| "Primary hemochromatosis is a common genetic disorder that results in inappropriate iron absorption and storage, with progressive damage to target organs." | ( Gushurst, TP; Triest, WE, 1990) |
| "Idiopathic hemochromatosis is a hereditary disease that is associated with human leucocytic antigens A3, B7, and B14." | ( Barron, R; Grace, ND; Powell, LW; Sherwood, G, 1989) |
| "Idiopathic hemochromatosis is a hereditary disease characterized by a progressive iron overload secondary to high intestinal iron absorption." | ( Marin, MG, 1985) |
| "Hereditary hemochromatosis is the most common cause of iron overload in adults and is probably the second most common cause of iron overload in children in the United States next to transfusional overload." | ( Castro, OL; Haddy, TB; Rana, SR, 1988) |
| "Hemochromatosis is a disease in which the inappropriate absorption of iron over 30-40 yr results in tissue iron overload and the development of cirrhosis of the liver, diabetes, hypogonadism, arthropathy, and skin pigmentation." | ( Adams, PC; Searle, J, 1988) |
| "Primary hemochromatosis is a genetic disorder rarely recognized in childhood; its long-term consequences include cirrhosis and liver cancer." | ( Escobar, GJ; Heyman, MB; Smith, WB; Thaler, MM, 1987) |
| "Hereditary hemochromatosis is an iron-storage disease in which total body iron stores can reach incredibly high levels, leading to damage of the liver, heart, pancreas, and pituitary gland." | ( Haines, JD, 1986) |
| "Hereditary hemochromatosis is inherited in an autosomal recessive manner with partial biochemical expression in heterozygotes." | ( Ghent, CN; Valberg, LS, 1985) |
| "Primary hemochromatosis is a genetic metabolic disorder associated with the HLA locus on chromosome 6 resulting in increased iron absorption, though erythropoiesis and dietary iron are normal, and abnormal diversion of iron from reticuloendothelial (RE) to parenchymal cells." | ( Pollycove, M, 1986) |
| "Neonatal hemochromatosis is a specific entity in the spectrum of pediatric liver disease." | ( Bartow, SA; Blisard, KS, 1986) |
| "Hemochromatosis is a syndrome which, when fully expressed, is manifested by melanoderma , diabetes mellitus, and liver cirrhosis, with iron overload involving parenchymal and reticuloendothelial cells in many organ systems." | ( Kellermeyer, RW; McLaren, GD; Muir, WA, 1983) |
| "Hereditary hemochromatosis is transmitted as an autosomal recessive trait." | ( Borwein, S; Ghent, CN; Valberg, LS, 1984) |
| "Idiopathic hemochromatosis is associated with certain HLA types." | ( Levin, DM; Rudy, DR, 1983) |
| "Hereditary hemochromatosis is an autosomal recessive disease in which the gene is linked to the HLA system." | ( Askari, A; Braun, W; McLaren, GD; Muir, WA, 1984) |
| "Since hemochromatosis is transmitted as an HLA-linked autosomal recessive disorder, HLA haplotypes serve as markers of hemochromatosis alleles." | ( Dadone, MM; Edwards, CQ; Kushner, JP; Skolnick, MH, 1982) |
| "Since hemochromatosis is transmitted as an HLA-linked autosomal recessive disorder, HLA haplotypes serve as markers of hemochromatosis alleles." | ( Edwards, CQ; Kushner, JP; Skolnick, MH, 1981) |
| "Postshunt hemochromatosis is an infrequently recognized condition that is a potentially reversible cause of cardiac or hepatic decompensation in patients with portacaval shunts." | ( Lombard, CM; Strauchen, JA, 1981) |
| "Although hereditary hemochromatosis is an autosomal recessive disease, most homozygotes are concerned with the genetic implications for their children." | ( Adams, PC; Kertesz, AE; Valberg, LS, 1995) |
| "Hemochromatosis is a disease of excessive iron storage leading to tissue damage and fibrosis." | ( Carthew, P; Dorman, BM; Edwards, RE; Francis, JE; Smith, AG, 1993) |
| "HLA-linked hemochromatosis is easily diagnosed, and routine screening in European-derived populations may be appropriate." | ( Bloom, PD; Gordeuk, VR; MacPhail, AP, 1995) |
| "Hemochromatosis is transmitted as autosomal recessive, and occurs in 3% of persons of Anglo-Saxon descent." | ( Welch, FJ, 1994) |
| "Hereditary hemochromatosis is a common disorder of iron metabolism with a prevalence as high as 8 per 1000." | ( Cappuccio, JD; Phatak, PD, 1994) |
| "Hereditary hemochromatosis is a prevalent inherited disorder with an estimated frequency of homozygosity of 0." | ( Conrad, ME; Moore, EG; Parmley, RT; Umbreit, JN, 1994) |
| "Hemochromatosis is common in mynah birds and human beings." | ( Hedstrom, OR; Pearson, EG; Poppenga, RH, 1994) |
| "Genetic hemochromatosis is one of the most common inherited disorders in Caucasian populations." | ( Crawford, DH; Halliday, JW; Powell, LW, 1996) |
| "Hemochromatosis is characterized by excessive absorption and subsequent deposition of iron in various organs and is prevalent in 1 out of 20,000 hospitalized patients." | ( Agudelo, CA; Stern, MA; Tanglao, EC, 1996) |
| "Hemochromatosis is a hereditary iron-overload disease linked to HLA." | ( Alves, H; Cabeda, JM; de Sousa, M; Fraga, J; Goncalves, C; Justiça, B; Lacerda, R; Macedo, G; Martins, O; Porto, G; Silva, BM; Teixeira, MA; Vicente, C, 1997) |
| "Hereditary hemochromatosis is a genetic disorder of iron metabolism that has an excellent prognosis if diagnosed early." | ( Holman, JR, 1997) |
| "Hemochromatosis is postulated to be caused by a heterozygous or homozygous defect of a gene on the short arm of the human chromosome 20 coding for an ubiquitous iron carrier membrane protein responsible for transporting iron ions out of cells." | ( Peuschel, KE, 1997) |
| "Genetic hemochromatosis is frequently not diagnosed in patients with diabetes, although it is a hallmark of the disease." | ( Aimo, G; Andreoletti, M; Colli, A; Conte, D; Corsetti, M; Fraquelli, M; Guala, A; Manachino, D, 1998) |
| "Although hemochromatosis is common in Caucasians, affecting >=1/300 individuals of northern European origin, it has not been recognized in other populations." | ( Cullen, LM; Easteal, S; Gao, X; Jazwinska, EC, 1998) |
| "Hemochromatosis is a common and often underdiagnosed disease." | ( Adams, PC, 1998) |
| "Hemochromatosis is the most common single gene disorder in Caucasian populations." | ( Chanu, B; Ferec, C; Le Faou, T; Le Poupon, AM; Mercier, AY; Mercier, B; Mura, C; Raguenes, O, 1998) |
| "Hemochromatosis is relatively common among white persons." | ( Braggins, C; Cappuccio, JD; Dunnigan, K; O'Leary, MT; Phatak, PD; Raubertas, RF; Sham, RL, 1998) |
| "Hemochromatosis is a hereditary disease characterized by increased absorption of iron from the gastrointestinal tract and deposition of iron in organs." | ( Hamberg, M; Holmberg, I; Stål, P, 1999) |
| "Hemochromatosis is the most common genetic disorder known in man and results in progressive tissue deposition of iron leading to cirrhosis of the liver, hepatic carcinoma, congestive heart failure, endocrinopathies, and premature death." | ( Gutierrez, JA; Wessling-Resnick, M; Yu, J, 1998) |
| "Hereditary hemochromatosis is a common autosomal recessive disorder of iron metabolism." | ( Brunmark, A; Jackson, MR; Leturcq, D; Li, Y; Peterson, PA; Salter-Cid, L; Yang, Y, 1999) |
| "Hereditary hemochromatosis is a common inherited disorder of iron metabolism." | ( Bacon, BR; Britton, RS; Brunt, EM; Olynyk, JK; Wolff, RK, 1999) |
| "Hereditary hemochromatosis is associated with homozygosity for the C282Y mutation in the hemochromatosis (HFE) gene on chromosome 6, elevated serum transferrin saturation, and excess iron deposits throughout the body." | ( Aquilia, S; Cullen, DJ; Olynyk, JK; Powell, LW; Rossi, E; Summerville, L, 1999) |
| "Hereditary hemochromatosis is characterized by increased intestinal absorption of iron leading to its deposition into multiple organs." | ( Batts, KP; Brandhagen, DJ; Fairbanks, VF; Thibodeau, SN, 1999) |
| "Neonatal hemochromatosis is characterized by abnormal hepatic and extrahepatic iron overload, which spares the reticuloendothelial system." | ( David, A; Joubert, M; Liet, JM; Moussali, F; Nomballais, F; Roze, JC; Urtin-Hostein, C, 2000) |
| "Hereditary hemochromatosis is a common inherited disorder of the iron metabolism." | ( Eijkelkamp, EJ; Powell, LW; Yapp, TR, 2000) |
| "Hemochromatosis is a common autosomal recessive condition found in the homozygous state in 1/200-1/400 people of northern-, central-, and western-European origin." | ( Beutler, E; Motulsky, AG, 2000) |
| "Juvenile hemochromatosis is a rare genetic disorder that causes iron overload." | ( Brunello, F; Camaschella, C; De Gobbi, M; Mazza, U; Paccotti, P; Pasquero, P, 2000) |
| "Hereditary hemochromatosis is an iron metabolism disorder known for a century, leading to iron overload and dysfunction of the major organs of the body." | ( Cibor, D; Ciećko-Michalska, I; Mach, T, 2000) |
| "Hereditary hemochromatosis is the most common inherited disorder in white population (2-8 cases per 1000 habitants)." | ( Cordeiro, E; de la Fuente, J; Gil, M; Martínez Cadilla, J; Martínez-Vázquez, C; Méndez, MJ; Seijas, M; Sopeña, B; Torres, J, 2000) |
| "Hereditary hemochromatosis is an inherited disorder of iron metabolism that is characterized by excessive iron deposition in major organs of the body." | ( Frank, EL; Lyon, E, 2001) |
| "Hemochromatosis is rare in domestic mammals." | ( Kelly, EJ; Layton, AW; McAllister, MM; Norrdin, RW; O'Toole, D; Russell, WC; Saeb-Parsy, K; Walker, AP, 2001) |
| "Hemochromatosis is a progressive iron overload disorder that is prevalent among individuals of European descent." | ( Andrews, NC; Cassanelli, S; Donovan, A; Garuti, C; Gasparini, P; Montosi, G; Pietrangelo, A; Pignatti, E; Totaro, A; Trenor, CC, 2001) |
| "Hemochromatosis is a genetic disease of iron overload due to intestinal hyperabsorption of iron." | ( Brissot, P, 2001) |
| "Hereditary hemochromatosis is the most common autosomal recessive disorder in populations of northern European descent." | ( Crawford, DH; Hickman, PE; McCullen, MA, 2002) |
| "Hereditary hemochromatosis is the most common inherited single-gene disorder in people of northern European descent." | ( Baldus, W; Brandhagen, DJ; Fairbanks, VF, 2002) |
| "Hereditary hemochromatosis is most commonly caused by homozygosity for a point mutation (C282Y) in the human hemochromatosis gene (HFE)." | ( Ajioka, RS; Andrews, NC; Kushner, JP; Levy, JE, 2002) |
| "Hereditary hemochromatosis is a disorder of iron metabolism, which is currently the most prevalent autosomal recessive disorder in the world, with an expression of the homozygous form occurring in approximately 1 in 200 individuals of European descent." | ( Bartfay, WJ; Crowe, S, 2002) |
| "Hemochromatosis is the most common hereditary condition in populations of Northern European descent, affecting three to five people per thousand." | ( Adams, PC; Harrison, H, 2002) |
| "Juvenile or type2 hemochromatosis is a rare autosomal recessive disorder which leads to severe iron overload early in life." | ( Camaschella, C; Caruso, R; Chianale, F; Daraio, F; De Gobbi, M; Longo, F; Piga, A; Pinto, RM, 2003) |
| "Hereditary hemochromatosis is an inherited pathological condition characterized by iron overload in several vital organs including heart." | ( Cordis, G; Das, DK; Jun, L; Maulik, N; Morris, JE; Stevens, RG; Turoczi, T, 2003) |
| "Hereditary hemochromatosis is associated with homozygosity for C282Y mutation in the HFE gene, elevated serum transferrin saturation and excess iron deposits throughout the body." | ( Ascaso, C; Bruguera, M; Ingelmo, M; Oliva, R; Sánchez, M; Sanz, C; Villa, M, 2003) |
| "Hereditary hemochromatosis is a common inherited disorder characterized by iron overload." | ( Chanu, B; Férec, C; Le Faou, T; Le Gac, G; Mercier, AY; Mérour, MC; Mura, C; Nousbaum, JB; Raguénes, O; Scotet, V, 2003) |
| "Hemochromatosis is the clinical expression of iron overload and occurs as hereditary and secondary variants." | ( Chalès, G; Guggenbuhl, P, 2003) |
| "Neonatal hemochromatosis is a rare gestational condition in which iron accumulates in the fetal tissues in a distribution like that seen in hereditary hemochromatosis." | ( Knisely, AS; Mieli-Vergani, G; Whitington, PF, 2003) |
| "Hereditary hemochromatosis is most commonly due to mutations in the HLA-linked HFE gene, and hemochromatosis clinically indistinguishable from HFE hemochromatosis is the consequence of mutations in three transferrin receptor-2 gene." | ( Beutler, E; Cook, JD; Hoffbrand, AV, 2003) |
| "Hemochromatosis is a genetic disorder of iron overload common in persons of northern European descent." | ( Calhoun, DC; Hicken, BL; Tucker, DC, 2003) |
| "Hemochromatosis is usually inherited in an autosomal recessive mode and associated with missense mutations in the hemochromatosis gene (HFE), an HLA class 1 related gene." | ( Addicks, N; Legler, T; Lynen, R; Raddatz, D; Ramadori, G, 2003) |
| "Hemochromatosis is a common autosomal recessive condition characterized by increased iron absorption and tissue deposition." | ( Jordan, JM, 2004) |
| "Type 3 hemochromatosis is a rare autosomal recessive disorder due to mutations of the TFR2 gene." | ( Arosio, C; Bovo, G; Mariani, R; Pelucchi, S; Piperno, A; Riva, A; Salvioni, A; Vergani, A, 2004) |
| "Hemochromatosis is a hereditary iron overload syndrome characterized by increased iron storage, followed by liver cirrhosis and is often associated with restrictive cardiomyopathy." | ( Jaschke, WR; Kremser, C; Metzler, B; Pachinger, O; Poelzl, G; Schocke, MF; Steinboeck, P; Vogel, W; Wolf, C; Zoller, H, 2004) |
| "Hereditary hemochromatosis is a common disorder of iron homeostasis characterized by increased dietary iron absorption and progressive iron accumulation, mainly in the liver." | ( Bahram, S; Bensaid, M; Coppin, H; Fruchon, S; Mazères, C; Roth, MP, 2004) |
| "Juvenile hemochromatosis is a rare autosomal recessive disorder characterized by the early onset of severe iron overload." | ( Andrews, NC; Fleming, MD; Huang, FW; Kushner, JP; Rubio-Aliaga, I, 2004) |
| "Juvenile hereditary hemochromatosis is a genetically heterogeneous disorder transmitted as an autosomal recessive trait." | ( Aguilar-Martinez, P; Beris, P; Darbellay, R; Ganz, T; Giostra, E; Matthes, T; Michel, M; Pizzi-Bosman, L; Rubbia-Brandt, L, 2004) |
| "Hereditary hemochromatosis is inherited as an autosomal recessive trait." | ( Attout, H; Guez, S; Sériès, C, 2004) |
| "Hemochromatosis is a genetic disorder characterized by progressive iron overload which leads to early abnormalities of iron parameters (increased transferrin saturation =TS and serum ferritin=SF) and late clinical complications." | ( Bondi, A; Camaschella, C; Castagno, F; D'Antico, S; De Gobbi, M; Merlini, R; Testa, D, 2004) |
| "Hereditary hemochromatosis is a genetic disorder, inherited as an autosomal recessive trait, characterized by iron overload." | ( Biesiada, G; Dropiński, J; Dziedzina, S; Mach, T; Sanak, M; Szczeklik, W; Szułdrzyński, K, 2004) |
| "Hereditary hemochromatosis is the most frequent hereditary metabolic disorder, with lethal outcome without treatment." | ( Dávid, K; Horváth, G, 2004) |
| "Hereditary hemochromatosis is a disorder of iron metabolism characterized by a progressive tissue iron overload which leads to an irreversible organ damage if it is not treated timely." | ( Franchini, M; Veneri, D, 2004) |
| "Type IV hemochromatosis is associated with dominant mutations in the SLC40A1 gene encoding ferroportin (FPN)." | ( Bastin, JM; Chinthammitr, Y; Cowley, D; Drakesmith, H; Edwards, JP; Merryweather-Clarke, AT; Robson, KJ; Schimanski, LM; Sweetland, E; Townsend, AR; Viprakasit, V, 2005) |
| "Iron overload and hemochromatosis are common, treatable conditions." | ( Acton, RT; Adams, PC; Barton, JC; Dawkins, FW; Eckfeldt, JH; Gordeuk, VR; Harris, EL; Holup, JL; Leiendecker-Foster, C; McLaren, CE; McLaren, GD; Reboussin, DM; Sholinsky, P; Snively, BM; Speechley, M; Thomson, E, 2005) |
| "HFE hemochromatosis is the most frequent genetic iron overload disease." | ( Brissot, P; Le Lan, C; Lescoat, G; Loréal, O; Lorho, R; Ropert, M; Troadec, MB, 2005) |
| "Hereditary hemochromatosis is a genetic disorder of iron metabolism." | ( Aronson, M; Fitterman, N; Owens, DK; Qaseem, A; Snow, V; Weiss, KB, 2005) |
| "Hereditary hemochromatosis is the most common autosomal recessive disease in populations of Northern European ancestry." | ( Meier, P; Schuff-Werner, P; Steiner, M, 2005) |
| "The term hemochromatosis is commonly used as synonymous with HFE-associated genetic iron overload but several rarer causes of an identical clinicopathological syndrome have been described in recent years." | ( O'Neil, J; Powell, L, 2005) |
| "Primary hemochromatosis is the most common genetic disorder with an allele frequency greater than 10% in individuals of European ancestry, while hemosiderosis is less common but associated with a much higher morbidity and mortality." | ( Backx, PH; Khaper, N; Liu, PP; Oudit, GY; Trivieri, MG, 2006) |
| "It also showed that hemochromatosis is a very complex disease and that the type of mutation can influence its clinical manifestation." | ( Bielawski, KP; Romanowski, T; Sikorska, K, 2006) |
| "Hereditary hemochromatosis is a relatively common genetic disorder characterized by excess dietary iron absorption and deposition in tissues with resulting end-organ damage." | ( Kowdley, KV; Wheeler, CJ, 2006) |
| "Hereditary hemochromatosis is an inherited disease in which most cells become overloaded with Fe." | ( Britigan, BE; Olakanmi, O; Schlesinger, LS, 2007) |
| "Hereditary Hemochromatosis is the most frequent modality of iron overload." | ( Alústiza, JM; Artetxe, J; Castiella, A; De Juan, MD; Emparanza, JI; Uranga, M, 2007) |
| "Hereditary hemochromatosis is now recognized as a very common inherited disease of the Caucasian population." | ( Bielawski, KP; Romanowski, T; Sikorska, K; Stalke, P, 2006) |
| "Genetic hemochromatosis is one of the most common genetic disorders, with progressive tissue iron overload leading to severe clinical complications." | ( Beaumont, C; Couchi, E; Demant, P; Deybach, JC; Fleming, R; Gouya, L; Grandchamp, B; Letteron, P; Lyoumi, S; Muzeau, F; Puy, H; Robreau, AM, 2007) |
| "Hemochromatosis is the clinical condition of iron overload; it can be genetic or secondary." | ( Chalès, G; Guggenbuhl, P; Pawlotsky, Y, 2006) |
| "Hemochromatosis is an congenital metabolic disorder depending on increase in intestinal iron absorbtion." | ( Brzosko, M; Butkiewicz-Trzcińska, B; Wódecki, M, 2006) |
| "Hereditary Hemochromatosis is an iron overload disease most frequently associated with mutations in the HFE gene." | ( Bhatt, L; Horgan, CP; McCaffrey, MW; Walsh, M, 2007) |
| "Neonatal hemochromatosis is a rare congenital disorder of the liver associated to a poor prognosis." | ( Foti, F; Iorio, R; Nicastro, E; Nicolò, A; Nicotina, PA; Timpani, G, 2007) |
| "Hemochromatosis is a recessively inherited disorder caused by a point mutation, C282Y of the HFE gene on chromosome 6p21." | ( Hansson, N; Olsson, KS; Ritter, B, 2007) |
| "Hereditary hemochromatosis is an inherited disorder of increased iron absorption that can result in cirrhosis, diabetes, and other morbidities." | ( Boros, LG; Cooksey, RC; Gabrielsen, JS; Hazel, MW; Huang, J; Jones, DL; Jouihan, HA; Knecht, L; Kushner, JP; Luo, B; McClain, DA; Soesanto, Y, 2007) |
| "Juvenile hemochromatosis is a severe and rapidly progressing hereditary disorder of iron overload, and it is caused primarily by defects in the gene encoding repulsive guidance molecule c/hemojuvelin (RGMc/HJV), a recently identified protein that undergoes a complicated biosynthetic pathway in muscle and liver, leading to cell membrane-linked single-chain and heterodimeric species, and two secreted single-chain isoforms." | ( Kuninger, D; Kuns-Hashimoto, R; Nili, M; Rotwein, P, 2008) |
| "Hemochromatosis is a common hereditary disease associated with progressive iron overload eventually leading to parenchymal damage of the liver, heart, pancreas, and other organs." | ( Chaudhry, S; Ismail, MK; Martinez-Hernandez, A; Schichman, S; Waters, B, 2009) |
| "Hemochromatosis is a common disease with a good prognosis, when diagnosed early and treated appropriately." | ( Asberg, A; Borch-Iohnsen, B; Hagve, TA; Thorstensen, K; Ulvik, R, 2009) |
| "Hereditary hemochromatosis is an autosomal recessive disease characterized by iron overload due to increased intestinal iron uptake over many years." | ( Asberg, A; Borch-Iohnsen, B; Hagve, TA; Thorstensen, K; Ulvik, R, 2009) |
| "Because secondary hemochromatosis is due to hereditary or acquired anemia, phlebotomy is not a suitable means of removing excess iron in this situation." | ( Gattermann, N, 2009) |
| "Genetic hemochromatosis is classified into four subtypes of which only type 1 is of clinical importance in Caucasians." | ( Niederau, C, 2009) |
| "Hemochromatosis is a common genetic disorder in which iron may progressively accumulate in the liver, heart, and other organs." | ( Adams, PC; Barton, JC, 2010) |
| "Hemochromatosis is now a well-defined syndrome characterized by normal iron-driven erythropoiesis and the toxic accumulation of iron in parenchymal cells of liver, heart, and endocrine glands." | ( Pietrangelo, A, 2010) |
| "Hereditary HFE Hemochromatosis is an inherited disorder of iron metabolism that results from mutations in the HFE gene." | ( Brehm, A; Spínola, C; Spínola, H, 2011) |
| "Genetic hemochromatosis is a cause of osteoporosis; mechanisms leading to iron-related bone loss are not fully characterized." | ( Chalès, G; Chappard, D; Doyard, M; Fergelot, P; Gallois, Y; Guggenbuhl, P; Libouban, H; Loréal, O; Roth, MP, 2011) |
| "Genetic hemochromatosis is a cause of osteoporosis." | ( Chalès, G; Chappard, D; Doyard, M; Fergelot, P; Gallois, Y; Guggenbuhl, P; Libouban, H; Loréal, O; Roth, MP, 2011) |
| "Hereditary hemochromatosis is an autosomal recessive condition causing excessive intestinal iron absorption related to C282Y hemochromatosis mutation gene." | ( Fernández Rodríguez, AM; García La Orden, I; Gascón, LH; Letosa, RM; Palop Cubillo, L; Rodríguez Pérez, JC; Rodríguez-Gallego, JC; Samper, RG; Santos, JP, 2011) |
| "Hemochromatosis is a genetic disorder of iron metabolism that results in elevated iron absorption in the intestines, which leads to progressive iron accumulation in a variety of organs." | ( Engel, JM; Onitilo, AA; Sajjad, SM, 2011) |
| "Hemochromatosis is an iron storage disorder with progressive and massive deposition of iron in the parenchymal cells of various organs." | ( Ito, K; Kubota, K; Minamimoto, R; Morooka, M, 2011) |
| "Hemochromatosis is associated not only with excessive accumulation of free iron in the retina and RPE but also with excessive accumulation of heme." | ( Ganapathy, V; Gnana-Prakasam, JP; Martin, PM; Reddy, SK; Smith, SB; Veeranan-Karmegam, R, 2011) |
| "Hemochromatosis is a common genetic disorder of iron metabolism." | ( Lynch, S; Soslau, G, 2012) |
| "Hemochromatosis is a disorder of the iron metabolism, characterized by high body iron content, necessitating frequent phlebotomies to remove excess iron." | ( Compernolle, V; De Buck, E; Dieltjens, T; Pauwels, NS; Vandekerckhove, P, 2012) |
| "Hereditary hemochromatosis is characterized by tissue iron loading and associated organ damage." | ( Lusby, PE; McDonald, CJ; Ostini, L; Ramm, GA; Subramaniam, VN; Wallace, DF; Wockner, LF, 2012) |
| "Hemochromatosis is a common disorder of iron overload most commonly due to homozogosity for the HFE C282Y substitution." | ( Aitken, M; Allen, KJ; Delatycki, MB; Halliday, J; Metcalfe, SA; Nisselle, A; Wolthuizen, M, 2013) |
| "Hemochromatosis is a disorder of iron overload arising mostly from mutations in HFE." | ( Coothankandaswamy, V; Ganapathy, V; Gnana-Prakasam, JP; Martin, PM; Reddy, SK; Smith, SB; Thangaraju, M; Veeranan-Karmegam, R, 2013) |
| "Hereditary hemochromatosis is an autosomal recessive disorder that disrupts the body's regulation of iron." | ( Covey, CJ; Crownover, BK, 2013) |
| "Neonatal hemochromatosis is a severe systemic iron-overload disorder due to gestational alloimmune liver disease caused by transplacental maternal IgG directed against the fetal liver." | ( Szalay, F, 2013) |
| "Hereditary hemochromatosis is a genetic disorder with mutations in the HFE gene, characterized by iron overload (with a reduced vitamin C stability) and with a predominance of affected men." | ( De Buyzere, ML; Delanghe, JR; Langlois, MR; Speeckaert, MM, 2013) |
| "Hereditary hemochromatosis is an autosomal recessive disorder characterized by severe iron overload." | ( Faustino, P; Gomes, S; Gonçalves, J; Pita, L; Silva, B, 2014) |
| "Hemochromatosis is the most common hereditary disorder in the Nordic population, if left untreated it can result in severe parenchymal iron accumulation." | ( Bolann, BJ; Distante, S; Mørkrid, L; Ulvik, RJ, 2015) |
| "Hereditary hemochromatosis is an autosomal recessive disorder of iron metabolism resulting in toxic accumulation of iron in vital organs." | ( Dominguez, ML; Garcia, L; Infante, JR; Moreno, M; Rayo, JI; Serrano, J, 2015) |
| "Hemochromatosis is the most common genetic disease in northern European populations." | ( Adams, PC, 2015) |
| "Hemochromatosis is not a rare disease in Pakistan and should be looked in those subjects whose liver function tests are deranged." | ( Akram, M; Parkash, O, 2015) |
| "Hereditary hemochromatosis is a heterogeneous group of genetic disorders characterized by parenchymal iron overload." | ( Bardou-Jacquet, E; Beaumont, C; Bedossa, P; Brissot, P; Daher, R; de Kerguenec, C; Ducrot, N; Gouya, L; Houamel, D; Jouanolle, AM; Kannengiesser, C; Karim, Z; Le Gac, G; Lefebvre, T; Loustaud-Ratti, V; Moulouel, B; Oudin, C; Puy, H; Robreau, AM; Tchernitchko, D; Valla, D, 2016) |
| "Hereditary hemochromatosis is a disorder of iron metabolism characterized by increased iron absorption." | ( Colaco, S; Colah, RB; Ghosh, K; Hariharan, P; Nadkarni, AH; Singh, AA, 2017) |
| "Hemochromatosis is the archetype of genetic iron overload diseases and represents a serious health problem." | ( Brissot, P; Cavey, T; Gaboriau, F; Loréal, O; Ropert, M, 2018) |
| "Juvenile hemochromatosis is the most severe form of iron overloading phenotype." | ( Cooray, SD; Hamblin, PS; Heerasing, NM; Leet, AS; McDonald, CJ; McLean, CA; McNamara, E; Roberts, SK; Selkrig, LA; Subramaniam, VN, 2018) |
| "HFE hemochromatosis is an inborn error of iron metabolism linked to a defect in the regulation of hepcidin synthesis." | ( Chanu, B; Ferec, C; L'Hostis, C; Le Gac, G; Merour, MC; Nousbaum, JB; Saliou, P; Scotet, V; Triponey, C; Uguen, M, 2018) |
| "Juvenile hemochromatosis is a rare autosomal recessive disease due to variants in the Hemojuvelin (HJV) gene." | ( Aggoune, S; Bardou-Jacquet, E; Ben Ali, Z; David, V; Detivaud, L; Deugnier, Y; Hamdi-Rozé, H; Pelletier, G; Ropert, M; Simon, D, 2019) |
| "Hereditary hemochromatosis is considered an inherited risk factor." | ( Cabezas Arteaga, JE; Silva Dos Reis, VM; Vieira, FMJ, 2019) |
| "Hereditary hemochromatosis is the classical example of a liver disease caused by iron, but iron is commonly believed to contribute to the progression of other forms of chronic liver disease such as hepatitis C infection and nonalcoholic fatty liver disease." | ( Bloomer, SA; Brown, KE, 2019) |
| "Although hereditary hemochromatosis is associated with the mutation of genes involved in iron transport and metabolism, secondary hemochromatosis is due to external factors, such as intended or unintended iron overload, hemolysis-linked iron exposure or other stress-impaired iron metabolism." | ( Moon, Y; Oh, CK, 2019) |
| "HFE-hemochromatosis is a disease characterized by a systemic iron overload phenotype mainly associated with mutations in the HFE protein (HFE) gene." | ( Camacho, A; Cancela, ML; Ea, HK; Gavaia, PJ; Pinto, IJ; Porto, G; Simão, M, 2019) |
| "Hereditary hemochromatosis is an autosomal recessive disorder of iron absorption, leading to organ dysfunction." | ( Borgaonkar, M; Lim, DR; Phua, C; Vidyasankar, G, 2020) |
| "HFE-related hemochromatosis is characterized by excessive intestinal absorption of dietary iron, in particular cases resulting in pathologically high iron storage in tissues and organs." | ( Antosiewicz, J; Kaczor, JJ; Kaczorowska-Hac, B; Luszczyk, M; Wasilewska, E, 2022) |
| "Hereditary hemochromatosis is a heterogenous group of inherited iron-overload conditions that is characterized by increased intestinal absorption and deposition in vital organs." | ( Hara, Y; Hino, K; Ikuta, K; Kato, A; Kato, K; Nishina, S; Sasaki, K; Tatsumi, Y; Toki, Y; Tomiyama, Y; Yoshioka, N, 2021) |
| "Hemochromatosis is an iron overload disease, which lacks nutritional intervention strategies." | ( Chen, L; Ding, H; Feng, J; Hong, Z; Wang, Z; Yu, X, 2021) |
| "Hereditary hemochromatosis is an autosomal recessive disorder that disrupts iron homeostasis, resulting in systemic iron overload." | ( Kane, SF; Paulus, R; Roberts, C, 2021) |
| "HFE hemochromatosis is the most common type of hemochromatosis, while non-HFE related hemochromatosis are rare cases." | ( Alberca, EP; Ferrer-Cortès, X; Giró, EC; Hernández, G; Kelleher, NJ; Mínguez, MÀR; Musri, M; Pelucchi, S; Pérez-Montero, S; Pilquil, MF; Piperno, A; Ricós, GG; Rodríguez, IH; Sánchez, M; Tornador, C; Torres, PMM; Venturi, V; Villà-Freixa, J, 2021) |
| "Hereditary hemochromatosis is the most commonly inherited disorder of systemic iron overload." | ( Adams, P; Chen, Y; Gharabaghi, S; Haacke, EM; Jog, MS; Reese, D; Sethi, SK; Sharma, S, 2022) |
| "HFE (Hemochromatosis) is a conventional iron level regulator and its loss of function due to gene mutations increases the risk of cancers including hepatocellular carcinoma (HCC)." | ( Au, CH; Cai, Z; Chan, AKY; Cheung, TT; Chiang, MWL; Dong, P; Lee, NP; Li, B; Lo, CM; Man, K; Sung, WK; Zhu, Y, 2022) |
| "Hemochromatosis is one of the most common inherited metabolic diseases among white populations and predominantly originates from a homozygous C282Y mutation in the HFE gene." | ( Bohne, J; Chung, B; Götting, J; Grimm, D; Hook, S; Hu, Q; Kempf, T; Krooss, SA; Ott, M; Rovai, A; Schmidt, F; Steinbrück, L; Talbot, SR; Yuan, Q, 2022) |
| "Hemochromatosis is a hereditary disorder, most often associated with mutations of the HFE (High FErrum) gene." | ( Bolann, BJ; Distante, S; Mørkrid, L; Ulvik, RJ; Yazdani, M, 2023) |
| "Hereditary hemochromatosis is an iron-overload disease most often arising from a mutation in the Homeostatic Fe regulator (HFE) gene." | ( Lindahl, PA; Vali, SW, 2023) |
| "Hereditary hemochromatosis is an iron-overload disease most often arising from a mutation in the Homeostatic Fe regulator (HFE) gene." | ( Lindahl, PA; Vali, SW, 2023) |
| "More than 95% of hemochromatosis are type 1 hemochromatosis but the phenotypic expression is highly variable." | ( Lobbes, H; Ruivard, M, 2023) |
| "Hemochromatosis is a genetic disorder characterized by increased iron storage in various organs with progressive multisystemic damage." | ( Bălănescu, AR; Caraiola, S; Cobilinschi, CO; Dumitru, RL; Husar-Sburlan, I; Nițu, AF; Opriș-Belinski, D; Săulescu, I, 2023) |