Page last updated: 2024-08-05 10:33:37
3-hydroxy carboxylic acid
Any hydroxy carboxylic acid which contains a hydroxy group located beta- to the carboxylic acid group.
ChEBI ID: 61355
Members (7)
| Member | Definition | Role |
|---|---|---|
| 3-hydroxyglutaric acid | A 3 hydroxy carboxylic acid that is glutaric acid which is substituted by a hydroxy group at position 3. It is a diagnostic marker for glutaric aciduria type I. | 3-hydroxyglutaric acid |
| alpha-isopropylmalate | A dicarboxylic acid that is malic acid (2-hydroxysuccinic acid) in which the hydrogen at position 2 is substituted by an isopropyl group. | 2-isopropylmalic acid |
| beta-hydroxyphenylpropionic acid | A 3-hydroxy carboxylic acid that is 3-phenylpropionic acid in which one of the hydrogens beta to the carboxy group is replaced by a hydroxy group. | 3-hydroxy-3-phenylpropionic acid |
| diethyl tartrate | Diethyl tartrate | |
| meglutol | A dicarboxylic acid that is glutaric acid in which one of the two hydrogens at position 3 is substituted by a hydroxy group, while the other is substituted by a methyl group. It has been found to accumulate in urine of patients suffering from HMG-CoA lyase (3-hydroxy-3-methylglutaryl-CoA lyase, EC 4.1.3.4) deficiency. It occurs as a plant metabolite in Crotalaria dura. | 3-hydroxy-3-methylglutaric acid |
| pravastatin | A carboxylic ester resulting from the formal condensation of (S)-2-methylbutyric acid with the hydroxy group adjacent to the ring junction of (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid. Derived from microbial transformation of mevastatin, pravastatin is a reversible inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA). The sodium salt is used for lowering cholesterol and preventing cardiovascular disease. It is one of the lower potency statins, but has the advantage of fewer side effects compared with lovastatin and simvastatin. | pravastatin |
| scopolamine | LSM-4015 |
Research
Studies (3,687)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 93 (2.52) | 18.7374 |
| 1990's | 973 (26.39) | 18.2507 |
| 2000's | 1,624 (44.05) | 29.6817 |
| 2010's | 864 (23.43) | 24.3611 |
| 2020's | 133 (3.61) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 1,039 (27.08%) | 5.53% |
| Reviews | 329 (8.57%) | 6.00% |
| Case Studies | 191 (4.98%) | 4.05% |
| Observational | 10 (0.26%) | 0.25% |
| Other | 2,268 (59.11%) | 84.16% |