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3-hydroxy carboxylic acid

Any hydroxy carboxylic acid which contains a hydroxy group located beta- to the carboxylic acid group.

ChEBI ID: 61355

Members (7)

MemberDefinitionRole
3-hydroxyglutaric acidA 3 hydroxy carboxylic acid that is glutaric acid which is substituted by a hydroxy group at position 3. It is a diagnostic marker for glutaric aciduria type I.3-hydroxyglutaric acid
alpha-isopropylmalateA dicarboxylic acid that is malic acid (2-hydroxysuccinic acid) in which the hydrogen at position 2 is substituted by an isopropyl group.2-isopropylmalic acid
beta-hydroxyphenylpropionic acidA 3-hydroxy carboxylic acid that is 3-phenylpropionic acid in which one of the hydrogens beta to the carboxy group is replaced by a hydroxy group.3-hydroxy-3-phenylpropionic acid
diethyl tartrateDiethyl tartrate
meglutolA dicarboxylic acid that is glutaric acid in which one of the two hydrogens at position 3 is substituted by a hydroxy group, while the other is substituted by a methyl group. It has been found to accumulate in urine of patients suffering from HMG-CoA lyase (3-hydroxy-3-methylglutaryl-CoA lyase, EC 4.1.3.4) deficiency. It occurs as a plant metabolite in Crotalaria dura.3-hydroxy-3-methylglutaric acid
pravastatinA carboxylic ester resulting from the formal condensation of (S)-2-methylbutyric acid with the hydroxy group adjacent to the ring junction of (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid. Derived from microbial transformation of mevastatin, pravastatin is a reversible inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA). The sodium salt is used for lowering cholesterol and preventing cardiovascular disease. It is one of the lower potency statins, but has the advantage of fewer side effects compared with lovastatin and simvastatin.pravastatin
scopolamineLSM-4015

Research

Studies (3,687)

TimeframeStudies, Drugs in This Class (%)All Drugs %
pre-199093 (2.52)18.7374
1990's973 (26.39)18.2507
2000's1,624 (44.05)29.6817
2010's864 (23.43)24.3611
2020's133 (3.61)2.80

Study Types

Publication TypeStudies, Drugs in This Class (%)All Drugs (%)
Trials1,039 (27.08%)5.53%
Reviews329 (8.57%)6.00%
Case Studies191 (4.98%)4.05%
Observational10 (0.26%)0.25%
Other2,268 (59.11%)84.16%