Page last updated: 2024-12-11
indicaxanthin
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
indicaxanthin: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 6096870 |
| CHEMBL ID | 4453776 |
| CHEBI ID | 5896 |
| SCHEMBL ID | 288232 |
| MeSH ID | M0443829 |
Synonyms (10)
| Synonym |
|---|
| indicaxanthin |
| 2181-75-1 |
| C08549 , |
| AC1O1I0D , |
| (2s)-1-[(2e)-2-[(2s)-2,6-dicarboxy-2,3-dihydro-1h-pyridin-4-ylidene]ethylidene]pyrrolidin-1-ium-2-carboxylate |
| SCHEMBL288232 |
| CHEBI:5896 |
| (1z,2s)-1-{(2e)-2-[(2s)-2,6-dicarboxy-2,3-dihydro-4(1h)-pyridinylidene]ethylidene}-2-pyrrolidinium carboxylate (indicaxanthin) |
| CHEMBL4453776 |
| Q3150365 |
Research Excerpts
Overview
Indicaxanthin is a betalain pigment found in prickly pear fruit. It has antiproliferative and pro-apoptotic activities in colorectal cancer cells.
Effects
| Excerpt | Reference | Relevance |
|---|---|---|
| "Indicaxanthin has pharmacokinetic proprieties, rarely found in other phytochemicals, and it has been demonstrated that it provides a broad-spectrum of pharmaceutical activity, exerting anti-proliferative, anti-inflammatory, and neuromodulator effects." | ( Reverse screening on indicaxanthin from Opuntia ficus-indica as natural chemoactive and chemopreventive agent. Almerico, AM; Tutone, M; Virzì, A, 2018) | 1.52 |
Treatment
| Excerpt | Reference | Relevance |
|---|---|---|
| "Pretreatment with indicaxanthin at 2 μmol/kg inhibited the carrageenin-induced release of PGE(2) (91.4%), NO (67.7%), IL-1β (53.6%), and TNF-α (71.1%), and caused a decrease of IL-1β (34.5%), TNF-α (81.6%), iNOS (75.2%), and COX2 (87.7%) mRNA, as well as iNOS (71.9%) and COX-2 (65.9%) protein expression, in the recruited leukocytes." | ( Indicaxanthin from cactus pear fruit exerts anti-inflammatory effects in carrageenin-induced rat pleurisy. Allegra, M; Ianaro, A; Livrea, MA; Panza, E; Tersigni, M; Tesoriere, L, 2014) | 2.17 |
Bioavailability
Food matrix did not affect trans-epithelial transfer of indicaxanthin. Reduced the absorption rate of betanin, red beet more than cactus pear.
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Drug Classes (1)
| Class | Description |
|---|---|
| non-proteinogenic alpha-amino acid | Any alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
Bioassays (10)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1510813 | Drug concentration in rat brain cerebellum at 2 mmol/kg, po after 1 hr | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Indicaxanthin, a multi-target natural compound from Opuntia ficus-indica fruit: From its poly-pharmacological effects to biochemical mechanisms and molecular modelling studies. |
| AID1510806 | Antiinflammatory activity in HUVEC assessed as reduction in TNF-alpha induced ICAM1 protein expression at 5 uM incubated for 5 hrs followed by TNFalpha-induction and measured after 16 hrs by flow cytometric analysis relative to control | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Indicaxanthin, a multi-target natural compound from Opuntia ficus-indica fruit: From its poly-pharmacological effects to biochemical mechanisms and molecular modelling studies. |
| AID1510807 | Drug concentration in rat brain at 2 umol/kg, po after 2.5 hrs | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Indicaxanthin, a multi-target natural compound from Opuntia ficus-indica fruit: From its poly-pharmacological effects to biochemical mechanisms and molecular modelling studies. |
| AID1510805 | Binding affinity to human LDL assessed per mg of protein | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Indicaxanthin, a multi-target natural compound from Opuntia ficus-indica fruit: From its poly-pharmacological effects to biochemical mechanisms and molecular modelling studies. |
| AID1510814 | Drug concentration in rat brain cortex at 2 mmol/kg, po after 1 hr | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Indicaxanthin, a multi-target natural compound from Opuntia ficus-indica fruit: From its poly-pharmacological effects to biochemical mechanisms and molecular modelling studies. |
| AID1510809 | Antitumor activity against human B16/F10 cells xenografted in C57BL/6 mouse assessed as reduction in tumor weight at 3.2 mg/kg, po measured after 14 days post transfection relative to control | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Indicaxanthin, a multi-target natural compound from Opuntia ficus-indica fruit: From its poly-pharmacological effects to biochemical mechanisms and molecular modelling studies. |
| AID1510812 | Plasma concentration in rat at 2 uM/kg, po after 2.5 hrs | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Indicaxanthin, a multi-target natural compound from Opuntia ficus-indica fruit: From its poly-pharmacological effects to biochemical mechanisms and molecular modelling studies. |
| AID1510808 | Antitumor activity against human B16/F10 cells xenografted in C57BL/6 mouse assessed as reduction in tumor volume at 3.2 mg/kg, po measured after 14 days post transfection relative to control | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Indicaxanthin, a multi-target natural compound from Opuntia ficus-indica fruit: From its poly-pharmacological effects to biochemical mechanisms and molecular modelling studies. |
| AID1510810 | Antitumor activity against human B16/F10 cells xenografted in C57BL/6 mouse assessed as reduction in CXCL1 level at 3.2 mg/kg, po measured after 14 days post transfection relative to control | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Indicaxanthin, a multi-target natural compound from Opuntia ficus-indica fruit: From its poly-pharmacological effects to biochemical mechanisms and molecular modelling studies. |
| AID1510811 | Antiproliferative activity against human Caco2 cells assessed as reduction in cell viability after 48 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Indicaxanthin, a multi-target natural compound from Opuntia ficus-indica fruit: From its poly-pharmacological effects to biochemical mechanisms and molecular modelling studies. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (30)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (26.67) | 29.6817 |
| 2010's | 20 (66.67) | 24.3611 |
| 2020's | 2 (6.67) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 28.45
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (28.45) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 1 (3.33%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 29 (96.67%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||