A substance used in the treatment or control of nematode infestations.
| Member | Definition | Class |
|---|
| 2-naphthol | A naphthol carrying a hydroxy group at position 2. | 2-naphthol |
| amocarzine | A thiourea resulting from the formal condensation of the secondary amino group of 1-methylpiperazine and the primary amino group of N-(4-nitrophenyl)benzene-1,4-diamine with carbonothioic O,O-acid. | amocarzine |
| ascaridole | A p-menthane monoterpenoid that is p-menth-2-ene with a peroxy group across position 1 to 4. | ascaridole |
| bay 44-4400 | A cyclooctadepsipeptide consisting of D-lactoyl, N-methyl-L-leucyl, 3-[4-(4-morpholinyl)phenyl]-D-lactoyl, N-methyl-L-leucyl, D-lactoyl, N-methyl-L-leucyl, 3-[4-(4-morpholinyl)phenyl]-D-lactoyl, and N-methyl-L-leucyl residues joined in sequence to give a 24-membered macrocycle. An anthelmintic, it is used with praziquantel for the treatment and control of hookworm, roundworm and tapeworm infections in cats. | emodepside |
| carbendazim | A member of the class of benzimidazoles that is 2-aminobenzimidazole in which the primary amino group is substituted by a methoxycarbonyl group. A fungicide, carbendazim controls Ascomycetes, Fungi Imperfecti, and Basidiomycetes on a wide variety of crops, including bananas, cereals, cotton, fruits, grapes, mushrooms, ornamentals, peanuts, sugarbeet, soybeans, tobacco, and vegetables. | carbendazim |
| coumaphos | | coumaphos |
| ethoprophos | | ethoprophos |
| fenbendazole | A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted at positons 2 and 5 by (methoxycarbonyl)amino and phenylsulfanediyl groups, respectively. A broad-spectrum anthelmintic, it is used, particularly in veterinary medicine, for the treatment of nematodal infections. | fenbendazole |
| flubendazole | A member of the class of mebendazole in which the benzoyl group is replaced by a p-fluorobenzoyl group. A broad-spectrum anthelmintic, it is used, particularly in veterinary medicine, for the treatment of nematodal infections. | flubendazole |
| kainic acid | | kainic acid |
| levamisole | A 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole that has S configuration. It is used (generally as the monohydrochloride salt) to treat parasitic worm infections in pigs, sheep and cattle and was formerly used in humans as an adjuvant to chemotherapy for the treatment of various cancers. It is also widely used as an adulterant to coccaine. | levamisole |
| mebendazole | A carbamate ester that is methyl 1H-benzimidazol-2-ylcarbamate substituted by a benzoyl group at position 5. | mebendazole |
| oxfendazole | A member of the class of benzimidazoles that is fenbendazole in which the sulfur has been oxidised to the corresponding sulfoxide. | oxfendazole |
| piperazine adipate | A piperazinium salt obtained by combining equimolar amounts of piperazine and adipic acid. | piperazine adipate |
| pyrantel | A carboxamidine that is 1,4,5,6-tetrahydropyrimidine that is substituted at position 1 by a methyl group and at position 2 by an (E)-2-(2-thienyl)vinyl group. It is used, particularly as the embonate [4,4'-methylenebis(3-hydroxy-2-naphthoate)] salt, as an anthelmintic that is effective against intestinal nematodes including threadworms, roundworms and hookworms, and is included in the WHO 'Model List of Essential Medicines'. | pyrantel |
| suramin | A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years. | suramin |
| suramin sodium | An organic sodium salt that is the hexasodium salt of suramin. It is an FDA approved drug for African sleeping sickness and river blindness. | suramin sodium |
| thiabendazole | A member of the class of benzimidazoles carrying a 1,3-thiazol-4-yl substituent at position 2. A mainly post-harvest fungicide used to control a wide range of diseases including Aspergillus, Botrytis, Cladosporium and Fusarium. | thiabendazole |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 27.6510 | 1 | 3 |
| 67.9K protein | Vaccinia virus | Potency | 1.6483 | 2 | 3 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 21.8378 | 4 | 13 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 22.6561 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 29.6889 | 1 | 5 |
| AR protein | Homo sapiens (human) | Potency | 20.3216 | 10 | 63 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 13.7163 | 3 | 34 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 22.2287 | 2 | 4 |
| Ataxin-2 | Homo sapiens (human) | Potency | 19.5118 | 1 | 7 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 16.4598 | 2 | 3 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 19.7214 | 2 | 13 |
| atrial natriuretic peptide receptor 1 precursor | Homo sapiens (human) | Potency | 3.0131 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 0.5036 | 2 | 3 |
| BRCA1 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 11.9527 | 1 | 4 |
| caspase-1 isoform alpha precursor | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 43.9871 | 1 | 2 |
| caspase-3 | Homo sapiens (human) | Potency | 11.9527 | 1 | 4 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 43.9871 | 1 | 2 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 11.1364 | 3 | 20 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 15.9027 | 2 | 3 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 33.4703 | 1 | 3 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 23.5870 | 3 | 5 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 5.0119 | 1 | 1 |
| Chain A, Breast cancer type 1 susceptibility protein | Homo sapiens (human) | Potency | 14.2191 | 1 | 2 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 28.8557 | 1 | 4 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 12.5893 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 17.3055 | 2 | 4 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 48.0224 | 1 | 2 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 146.1416 | 3 | 6 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 13.1025 | 2 | 8 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 17.3055 | 2 | 4 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 35.1798 | 1 | 2 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 1.5849 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 15.7189 | 1 | 3 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 21.6922 | 1 | 6 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 22.3083 | 2 | 6 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 10.5012 | 2 | 4 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 18.1238 | 1 | 8 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | Potency | 15.8489 | 1 | 2 |
| DNA dC->dU-editing enzyme APOBEC-3F isoform a | Homo sapiens (human) | Potency | 2.8184 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 0.8913 | 1 | 1 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 0.2239 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 1.4125 | 1 | 1 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 13.3141 | 1 | 3 |
| dopamine D1 receptor | Homo sapiens (human) | Potency | 8.1995 | 1 | 1 |
| endonuclease IV | Escherichia coli | Potency | 11.4804 | 2 | 3 |
| Endothelin receptor type B | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Endothelin-1 receptor | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 22.6536 | 10 | 53 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 43.0465 | 3 | 11 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 21.8557 | 6 | 63 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 8.5133 | 1 | 5 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 4.8939 | 4 | 18 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 12.8990 | 2 | 10 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 3.7686 | 1 | 1 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 13.0985 | 1 | 5 |
| G | Vesicular stomatitis virus | Potency | 15.7189 | 1 | 3 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 22.3083 | 1 | 3 |
| galactokinase | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
| GALC protein | Homo sapiens (human) | Potency | 0.6310 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 22.3083 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 22.3083 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 22.3083 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 22.3083 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 22.3083 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 22.3083 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 22.3083 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 22.3083 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 22.3083 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 22.3083 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 22.3083 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 22.3083 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 22.3083 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 22.3083 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 22.3083 | 1 | 3 |
| geminin | Homo sapiens (human) | Potency | 5.7038 | 2 | 11 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 10.9993 | 2 | 22 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 11.7546 | 1 | 2 |
| GLS protein | Homo sapiens (human) | Potency | 7.2680 | 2 | 2 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 20.4280 | 4 | 12 |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | Potency | 8.9125 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 17.6864 | 2 | 6 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | Potency | 8.9125 | 1 | 1 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | Potency | 8.9125 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 28.7010 | 1 | 4 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 2.2159 | 2 | 5 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 13.7046 | 2 | 16 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 64.5797 | 2 | 9 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 11.0344 | 1 | 2 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 15.7189 | 1 | 3 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 5.6234 | 1 | 1 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 4.7644 | 2 | 8 |
| IDH1 | Homo sapiens (human) | Potency | 19.7813 | 1 | 3 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 15.7189 | 1 | 6 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 15.6730 | 1 | 2 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 11.2947 | 1 | 2 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 11.2947 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 8.0276 | 3 | 18 |
| interleukin 8 | Homo sapiens (human) | Potency | 74.9780 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 2.0798 | 2 | 8 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 2.5119 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 26.0007 | 3 | 16 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 23.1822 | 2 | 6 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 1.5849 | 1 | 1 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 0.3548 | 2 | 2 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 3.5481 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 37.2814 | 4 | 18 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 13.2005 | 1 | 2 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 61.6448 | 1 | 1 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 9.4392 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 21.3927 | 2 | 3 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 0.7414 | 1 | 2 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 16.2037 | 3 | 45 |
| Ornithine decarboxylase | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| P53 | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 9.3419 | 2 | 7 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 29.6926 | 2 | 4 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 13.0564 | 3 | 7 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 40.3694 | 1 | 4 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 5.0100 | 1 | 2 |
| Platelet-activating factor receptor | Homo sapiens (human) | Potency | 14.2191 | 1 | 2 |
| polyprotein | Zika virus | Potency | 13.0985 | 1 | 5 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| PPM1D protein | Homo sapiens (human) | Potency | 5.8845 | 1 | 8 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 27.3273 | 3 | 24 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 21.0643 | 1 | 5 |
| progesterone receptor | Homo sapiens (human) | Potency | 14.9645 | 1 | 7 |
| pyruvate kinase | Leishmania mexicana mexicana | Potency | 19.2914 | 4 | 5 |
| pyruvate kinase PKM isoform b | Homo sapiens (human) | Potency | 31.6228 | 2 | 2 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 25.2677 | 2 | 21 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 2.5119 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 0.0075 | 1 | 1 |
| relaxin receptor 1 isoform 1 | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 13.8085 | 3 | 32 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 14.0220 | 3 | 14 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 18.3651 | 2 | 5 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 18.3651 | 2 | 5 |
| Smad3 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| snurportin-1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 3.5507 | 1 | 3 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 12.8301 | 1 | 5 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 9.8945 | 2 | 25 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 3.4840 | 1 | 3 |
| Thrombopoietin | Homo sapiens (human) | Potency | 3.9811 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 11.0873 | 3 | 19 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 11.8763 | 2 | 3 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 22.4143 | 6 | 13 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 15.8489 | 1 | 2 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 5.0100 | 1 | 2 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 5.0100 | 1 | 2 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 19.4825 | 2 | 9 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 8.3384 | 2 | 9 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 19.4411 | 1 | 5 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 5'-nucleotidase | Rattus norvegicus (Norway rat) | IC50 | 20.2000 | 1 | 1 |
| Adenosine receptor A2a | Homo sapiens (human) | IC50 | 1.5040 | 1 | 1 |
| Adenosine receptor A2a | Homo sapiens (human) | Ki | 0.8440 | 1 | 1 |
| Alkaline phosphatase, placental type | Homo sapiens (human) | IC50 | 400.0000 | 4 | 4 |
| Alkaline phosphatase, tissue-nonspecific isozyme | Homo sapiens (human) | IC50 | 16.1525 | 4 | 4 |
| Alkaline phosphatase, tissue-nonspecific isozyme | Homo sapiens (human) | Ki | 16.0000 | 1 | 1 |
| Alkaline phosphatase, tissue-nonspecific isozyme | Bos taurus (cattle) | IC50 | 19.4060 | 5 | 5 |
| Alkaline phosphatase, tissue-nonspecific isozyme | Bos taurus (cattle) | Ki | 1.8100 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| ATP-dependent 6-phosphofructokinase | Trypanosoma brucei brucei | IC50 | 3.0000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 564.3333 | 2 | 3 |
| Calmodulin-domain protein kinase 1 | Toxoplasma gondii | IC50 | 0.6700 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 61.7000 | 1 | 1 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 9.5200 | 1 | 1 |
| Carbonic anhydrase 13 | Homo sapiens (human) | Ki | 4.2300 | 1 | 1 |
| Carbonic anhydrase 14 | Homo sapiens (human) | Ki | 4.1400 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 200.0000 | 1 | 1 |
| Carbonic anhydrase 3 | Homo sapiens (human) | Ki | 4.6200 | 1 | 1 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 5.4800 | 1 | 1 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 5.0900 | 1 | 1 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | Ki | 3.4100 | 1 | 1 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Ki | 2.2300 | 1 | 1 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 4.6800 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 6.4100 | 1 | 1 |
| Cathepsin B | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| Chain A, Methionine aminopeptidase | Escherichia coli | Ki | 0.4000 | 1 | 1 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 8.9000 | 2 | 2 |
| Cytochrome P450 2A5 | Mus musculus (house mouse) | IC50 | 77.9915 | 2 | 2 |
| Cytochrome P450 2A6 | Homo sapiens (human) | IC50 | 139.9795 | 2 | 2 |
| Cytochrome P450 2C9 | Homo sapiens (human) | Ki | 245.0000 | 1 | 1 |
| D(3) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 18.1000 | 1 | 1 |
| DNA primase | Mycobacterium tuberculosis CDC1551 | IC50 | 8.2000 | 1 | 1 |
| DNA-dependent protein kinase catalytic subunit | Homo sapiens (human) | IC50 | 1.7000 | 1 | 1 |
| Dual specificity protein phosphatase 5 | Homo sapiens (human) | Ki | 0.0250 | 1 | 1 |
| Ectonucleoside triphosphate diphosphohydrolase 1 | Rattus norvegicus (Norway rat) | Ki | 300.0000 | 2 | 2 |
| Ectonucleoside triphosphate diphosphohydrolase 2 | Rattus norvegicus (Norway rat) | Ki | 65.4000 | 2 | 2 |
| Ectonucleoside triphosphate diphosphohydrolase 3 | Rattus norvegicus (Norway rat) | Ki | 12.7000 | 1 | 1 |
| Ectonucleoside triphosphate diphosphohydrolase 8 | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| Fatty-acid amide hydrolase 1 | Rattus norvegicus (Norway rat) | IC50 | 7.6180 | 1 | 4 |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | IC50 | 16.2500 | 7 | 8 |
| Glutamate receptor 1 | Homo sapiens (human) | Ki | 7.4663 | 3 | 3 |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | Ki | 0.4770 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | IC50 | 16.2500 | 7 | 8 |
| Glutamate receptor 2 | Homo sapiens (human) | Ki | 12.2070 | 3 | 3 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Ki | 4.9950 | 2 | 2 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | IC50 | 16.2500 | 7 | 8 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | Ki | 1.9800 | 1 | 1 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | IC50 | 16.2500 | 7 | 8 |
| Glutamate receptor 4 | Homo sapiens (human) | Ki | 1.7113 | 3 | 3 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | Ki | 3.5700 | 1 | 1 |
| Glutamate receptor ionotropic, kainate 1 | Homo sapiens (human) | IC50 | 0.0770 | 1 | 1 |
| Glutamate receptor ionotropic, kainate 1 | Rattus norvegicus (Norway rat) | IC50 | 0.0126 | 8 | 10 |
| Glutamate receptor ionotropic, kainate 1 | Homo sapiens (human) | Ki | 0.1770 | 2 | 2 |
| Glutamate receptor ionotropic, kainate 1 | Rattus norvegicus (Norway rat) | Ki | 0.0742 | 2 | 3 |
| Glutamate receptor ionotropic, kainate 2 | Homo sapiens (human) | IC50 | 0.0770 | 1 | 1 |
| Glutamate receptor ionotropic, kainate 2 | Rattus norvegicus (Norway rat) | IC50 | 0.0126 | 8 | 10 |
| Glutamate receptor ionotropic, kainate 2 | Homo sapiens (human) | Ki | 0.0391 | 3 | 3 |
| Glutamate receptor ionotropic, kainate 2 | Rattus norvegicus (Norway rat) | Ki | 0.0104 | 3 | 4 |
| Glutamate receptor ionotropic, kainate 3 | Homo sapiens (human) | IC50 | 0.0770 | 1 | 1 |
| Glutamate receptor ionotropic, kainate 3 | Rattus norvegicus (Norway rat) | IC50 | 0.0126 | 8 | 10 |
| Glutamate receptor ionotropic, kainate 3 | Homo sapiens (human) | Ki | 0.0100 | 2 | 2 |
| Glutamate receptor ionotropic, kainate 3 | Rattus norvegicus (Norway rat) | Ki | 0.0183 | 1 | 2 |
| Glutamate receptor ionotropic, kainate 4 | Homo sapiens (human) | IC50 | 0.0770 | 1 | 1 |
| Glutamate receptor ionotropic, kainate 4 | Rattus norvegicus (Norway rat) | IC50 | 0.0126 | 8 | 10 |
| Glutamate receptor ionotropic, kainate 4 | Rattus norvegicus (Norway rat) | Ki | 0.0047 | 1 | 1 |
| Glutamate receptor ionotropic, kainate 5 | Homo sapiens (human) | IC50 | 0.0770 | 1 | 1 |
| Glutamate receptor ionotropic, kainate 5 | Rattus norvegicus (Norway rat) | IC50 | 0.0126 | 8 | 10 |
| Glutamate receptor ionotropic, kainate 5 | Homo sapiens (human) | Ki | 0.0883 | 3 | 3 |
| Glutamate receptor ionotropic, kainate 5 | Rattus norvegicus (Norway rat) | Ki | 0.0150 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 6 | 7 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | Ki | 68.7667 | 3 | 3 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 5 | 6 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | Ki | 68.7667 | 3 | 3 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 5 | 6 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | Ki | 68.7667 | 3 | 3 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 5 | 6 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | Ki | 68.7667 | 3 | 3 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 5 | 6 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | Ki | 68.7667 | 3 | 3 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 5 | 6 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | Ki | 68.7667 | 3 | 3 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 5 | 6 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | Ki | 68.7667 | 3 | 3 |
| Hematopoietic prostaglandin D synthase | Homo sapiens (human) | IC50 | 300.0000 | 1 | 1 |
| Intestinal-type alkaline phosphatase | Bos taurus (cattle) | IC50 | 171.7220 | 5 | 5 |
| Intestinal-type alkaline phosphatase | Homo sapiens (human) | IC50 | 205.0420 | 5 | 5 |
| Methionine aminopeptidase | Escherichia coli K-12 | IC50 | 7.6180 | 1 | 4 |
| Methionine aminopeptidase 1 | Homo sapiens (human) | IC50 | 47.8000 | 1 | 1 |
| Methionine aminopeptidase 2 | Homo sapiens (human) | IC50 | 44.7000 | 1 | 1 |
| Mitogen-activated protein kinase 14 | Homo sapiens (human) | IC50 | 3.1880 | 1 | 1 |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 15.5000 | 1 | 1 |
| NAD-dependent protein deacetylase HST2 | Saccharomyces cerevisiae S288C | IC50 | 240.0000 | 1 | 1 |
| NAD-dependent protein deacetylase sirtuin-1 | Homo sapiens (human) | IC50 | 1.3857 | 7 | 7 |
| NAD-dependent protein deacetylase sirtuin-2 | Homo sapiens (human) | IC50 | 1.1750 | 4 | 4 |
| NAD-dependent protein deacylase sirtuin-5, mitochondrial | Homo sapiens (human) | IC50 | 20.6000 | 8 | 8 |
| P2X purinoceptor 2 | Rattus norvegicus (Norway rat) | IC50 | 21.9054 | 1 | 2 |
| P2Y purinoceptor 11 | Homo sapiens (human) | Ki | 0.2071 | 2 | 2 |
| P2Y purinoceptor 2 | Homo sapiens (human) | IC50 | 75.0000 | 2 | 2 |
| P2Y purinoceptor 6 | Homo sapiens (human) | IC50 | 27.0000 | 1 | 1 |
| Phospholipase A-2-activating protein | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Protein arginine N-methyltransferase 1 | Homo sapiens (human) | IC50 | 344.8100 | 3 | 3 |
| Protein kinase C alpha type | Homo sapiens (human) | IC50 | 29.0000 | 1 | 1 |
| Protein kinase C beta type | Homo sapiens (human) | IC50 | 29.0000 | 1 | 1 |
| Protein kinase C delta type | Homo sapiens (human) | IC50 | 29.0000 | 1 | 1 |
| Protein kinase C epsilon type | Homo sapiens (human) | IC50 | 29.0000 | 1 | 1 |
| Protein kinase C eta type | Homo sapiens (human) | IC50 | 29.0000 | 1 | 1 |
| Protein kinase C gamma type | Homo sapiens (human) | IC50 | 29.0000 | 1 | 1 |
| Protein kinase C iota type | Homo sapiens (human) | IC50 | 29.0000 | 1 | 1 |
| Protein kinase C theta type | Homo sapiens (human) | IC50 | 29.0000 | 1 | 1 |
| Protein kinase C zeta type | Homo sapiens (human) | IC50 | 29.0000 | 1 | 1 |
| Proto-oncogene tyrosine-protein kinase Src | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Proto-oncogene tyrosine-protein kinase Src | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| Reverse transcriptase/RNaseH | Human immunodeficiency virus 1 | IC50 | 13.0000 | 3 | 3 |
| RmtA | Aspergillus nidulans | IC50 | 5.9000 | 1 | 1 |
| Serine/threonine-protein kinase D1 | Homo sapiens (human) | IC50 | 29.0000 | 1 | 1 |
| Serine/threonine-protein kinase D3 | Homo sapiens (human) | IC50 | 29.0000 | 1 | 1 |
| Signal transducer and activator of transcription 1-alpha/beta | Homo sapiens (human) | IC50 | 9.1000 | 1 | 1 |
| Signal transducer and activator of transcription 3 | Mus musculus (house mouse) | IC50 | 100.0000 | 1 | 1 |
| Signal transducer and activator of transcription 5A | Homo sapiens (human) | IC50 | 9.4000 | 1 | 1 |
| Signal transducer and activator of transcription 5B | Homo sapiens (human) | IC50 | 10.4000 | 1 | 1 |
| Tyrosine-protein kinase ABL1 | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Tyrosine-protein kinase ABL1 | Homo sapiens (human) | Ki | 4.6000 | 1 | 1 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 | 9.7600 | 1 | 1 |
| Uracil nucleotide/cysteinyl leukotriene receptor | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Vascular endothelial growth factor receptor 2 | Homo sapiens (human) | IC50 | 5.5667 | 3 | 3 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| Chain A, Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Kd | 0.1600 | 1 | 2 |
| Chain C, Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Kd | 0.1600 | 1 | 1 |
| Delta-type opioid receptor | Homo sapiens (human) | EC50 | 100.0000 | 1 | 1 |
| DNA repair and recombination protein RadA | Pyrococcus furiosus DSM 3638 | Kd | 460.0000 | 1 | 1 |
| Glutamate receptor 1 | Homo sapiens (human) | EC50 | 49.5025 | 4 | 4 |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | EC50 | 24.3333 | 3 | 3 |
| Glutamate receptor 2 | Homo sapiens (human) | EC50 | 34.0350 | 2 | 2 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | EC50 | 380.0000 | 2 | 2 |
| Glutamate receptor 3 | Homo sapiens (human) | EC50 | 26.6100 | 1 | 1 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | EC50 | 37.0000 | 3 | 3 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | EC50 | 47.0000 | 2 | 2 |
| Glutamate receptor ionotropic, kainate 1 | Homo sapiens (human) | EC50 | 16.2000 | 2 | 2 |
| Glutamate receptor ionotropic, kainate 1 | Rattus norvegicus (Norway rat) | EC50 | 37.0000 | 1 | 1 |
| Glutamate receptor ionotropic, kainate 2 | Homo sapiens (human) | EC50 | 0.7000 | 2 | 2 |
| Glutamate receptor ionotropic, kainate 2 | Rattus norvegicus (Norway rat) | EC50 | 1.8000 | 1 | 1 |
| Glutamate receptor ionotropic, kainate 2 | Rattus norvegicus (Norway rat) | Kd | 0.0390 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | EC50 | 25.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | EC50 | 25.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | EC50 | 25.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | EC50 | 25.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | EC50 | 25.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | EC50 | 25.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | EC50 | 25.0000 | 1 | 1 |
| Kappa-type opioid receptor | Homo sapiens (human) | EC50 | 100.0000 | 1 | 1 |
| Metabotropic glutamate receptor 5 | Homo sapiens (human) | EC50 | 33.6000 | 1 | 1 |
| Metabotropic glutamate receptor 6 | Homo sapiens (human) | EC50 | 299.0000 | 1 | 1 |
| Methionine aminopeptidase 1 | Homo sapiens (human) | EC50 | 117.8000 | 3 | 3 |
| Mu-type opioid receptor | Homo sapiens (human) | EC50 | 100.0000 | 1 | 1 |
| Nuclear receptor subfamily 1 group I member 2 | Homo sapiens (human) | EC50 | 5.6500 | 2 | 2 |
| Nuclear receptor subfamily 1 group I member 2 | Rattus norvegicus (Norway rat) | EC50 | 4.0000 | 1 | 1 |
| P2X purinoceptor 1 | Rattus norvegicus (Norway rat) | EC50 | 1.0000 | 1 | 1 |
| P2X purinoceptor 2 | Rattus norvegicus (Norway rat) | EC50 | 10.4000 | 1 | 1 |
| P2X purinoceptor 3 | Homo sapiens (human) | EC50 | 8.9500 | 2 | 2 |
| P2X purinoceptor 4 | Rattus norvegicus (Norway rat) | EC50 | 100.0000 | 1 | 1 |
| P2X purinoceptor 5 | Rattus norvegicus (Norway rat) | EC50 | 4.0000 | 1 | 1 |
| P2X purinoceptor 6 | Rattus norvegicus (Norway rat) | EC50 | 100.0000 | 1 | 1 |
| P2X purinoceptor 7 | Homo sapiens (human) | EC50 | 92.0000 | 1 | 1 |
| P2Y purinoceptor 1 | Meleagris gallopavo (turkey) | EC50 | 10.0000 | 1 | 1 |
| P2Y purinoceptor 11 | Homo sapiens (human) | EC50 | 16.0000 | 1 | 1 |
| P2Y purinoceptor 12 | Rattus norvegicus (Norway rat) | EC50 | 4.0000 | 1 | 1 |
| P2Y purinoceptor 2 | Homo sapiens (human) | EC50 | 48.0000 | 1 | 1 |
| P2Y purinoceptor 4 | Homo sapiens (human) | EC50 | 100.0000 | 1 | 1 |
| Peptidyl-prolyl cis-trans isomerase FKBP1A | Homo sapiens (human) | Kd | 60.0000 | 1 | 1 |