A role borne by a molecule that acts to counteract or neutralize the deleterious effects of paracetamol (acetaminophen).
ChEBI ID: 74529
| Member | Definition | Class |
|---|---|---|
| acetylcysteine | An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine. | N-acetyl-L-cysteine |
| methionine | The L-enantiomer of methionine. | L-methionine zwitterion; L-methionine |
| propylthiouracil | A pyrimidinethione consisting of uracil in which the 2-oxo group is substituted by a thio group and the hydrogen at position 6 is substituted by a propyl group. | 6-propyl-2-thiouracil |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 16,175 (36.53) | 18.7374 |
| 1990's | 6,458 (14.58) | 18.2507 |
| 2000's | 9,105 (20.56) | 29.6817 |
| 2010's | 9,566 (21.60) | 24.3611 |
| 2020's | 2,978 (6.73) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 1,696 (3.65%) | 5.53% |
| Reviews | 2,340 (5.04%) | 6.00% |
| Case Studies | 1,628 (3.51%) | 4.05% |
| Observational | 47 (0.10%) | 0.25% |
| Other | 40,713 (87.70%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 0.0251 | 1 | 1 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 31.6538 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 6.3632 | 2 | 2 |
| arylsulfatase A | Homo sapiens (human) | Potency | 37.9330 | 1 | 1 |
| Ataxin-2 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 26.8545 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 1.0000 | 2 | 2 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 1.4125 | 1 | 1 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 17.7407 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 5.8045 | 1 | 1 |
| dopamine D1 receptor | Homo sapiens (human) | Potency | 0.0206 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 24.5542 | 2 | 5 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 14.3388 | 1 | 4 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 35.1973 | 2 | 2 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 26.6795 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 1.6044 | 2 | 3 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 0.0028 | 1 | 1 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 33.4889 | 1 | 1 |
| interleukin 8 | Homo sapiens (human) | Potency | 74.9780 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 0.0009 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 24.7028 | 1 | 2 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 4.4668 | 2 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 42.1632 | 1 | 1 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 40.5334 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 63.6261 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 45.2396 | 1 | 3 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 70.7576 | 1 | 1 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 13.3332 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 0.2376 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 36.0272 | 2 | 2 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 9.2111 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 1.5849 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 20.5962 | 1 | 1 |
| Thrombopoietin | Homo sapiens (human) | Potency | 31.6228 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 21.6458 | 1 | 1 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 0.5623 | 1 | 1 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 10.0000 | 2 | 2 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 0.5618 | 1 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Chain A, Aminopeptidase | Streptomyces griseus | Ki | 8,700.0000 | 1 | 1 |
| Chain A, Methionine aminopeptidase | Pyrococcus furiosus | Ki | 150,000.0000 | 1 | 1 |
| Fatty acid synthase | Homo sapiens (human) | Ki | 150,000.0000 | 1 | 1 |
| Histone deacetylase 1 | Homo sapiens (human) | IC50 | 3,160.0000 | 1 | 1 |
| Histone deacetylase 11 | Homo sapiens (human) | IC50 | 3,160.0000 | 1 | 1 |
| Histone deacetylase 2 | Homo sapiens (human) | IC50 | 3,160.0000 | 1 | 1 |
| Histone deacetylase 3 | Homo sapiens (human) | IC50 | 3,160.0000 | 1 | 1 |
| Histone deacetylase 4 | Homo sapiens (human) | IC50 | 3,160.0000 | 1 | 1 |
| Histone deacetylase 5 | Homo sapiens (human) | IC50 | 3,160.0000 | 1 | 1 |
| Histone deacetylase 6 | Homo sapiens (human) | IC50 | 3,160.0000 | 1 | 1 |
| Histone deacetylase 7 | Homo sapiens (human) | IC50 | 3,160.0000 | 1 | 1 |
| Histone deacetylase 8 | Homo sapiens (human) | IC50 | 3,160.0000 | 1 | 1 |
| Histone deacetylase 9 | Homo sapiens (human) | IC50 | 3,160.0000 | 1 | 1 |
| Large neutral amino acids transporter small subunit 1 | Homo sapiens (human) | IC50 | 175.0000 | 2 | 2 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Myeloperoxidase | Homo sapiens (human) | IC50 | 2.8100 | 1 | 1 |
| NADH-cytochrome b5 reductase 3 | Homo sapiens (human) | IC50 | 279.4000 | 1 | 1 |
| Polyamine deacetylase HDAC10 | Homo sapiens (human) | IC50 | 3,160.0000 | 1 | 1 |
| S-ribosylhomocysteine lyase | Bacillus subtilis subsp. subtilis str. 168 | Ki | 61.0000 | 1 | 1 |
| Solute carrier family 22 member 6 | Rattus norvegicus (Norway rat) | Ki | 2,000.0000 | 1 | 1 |
| Thyroid peroxidase | Homo sapiens (human) | IC50 | 3.3800 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Chain A, Methionyl-tRNA synthetase | Escherichia coli | Kd | 11.0000 | 1 | 2 |
| Taste receptor type 2 member 38 | Homo sapiens (human) | EC50 | 2.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Adenylate cyclase type 5 | Homo sapiens (human) | Km | 15.6000 | 1 | 1 |
| S-adenosylmethionine synthase isoform type-1 | Rattus norvegicus (Norway rat) | Km | 42.8000 | 2 | 2 |
| S-adenosylmethionine synthase isoform type-2 | Rattus norvegicus (Norway rat) | Km | 10.3000 | 2 | 2 |
| Taste receptor type 2 member 38 | Homo sapiens (human) | Activity | 0.3000 | 1 | 1 |