Page last updated: 2024-12-11

sibiricose a6

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

sibiricose A6: isolated from root bark of Polygala tenuifolia; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
PolygalagenusA plant genus of the family POLYGALACEAE that contains onjisaponins, xanthones, pyrones, and benzophenones. The name is similar to other snakeroots such as ASARUM; SANICULA; ARISTOLOCHIA; AGERATINA; and others.[MeSH]PolygalaceaeA plant family of the order Polygalales, subclass Rosidae, class Magnoliopsida.[MeSH]

Cross-References

ID SourceID
PubMed CID6326021
CHEMBL ID3581236
MeSH IDM0479100

Synonyms (9)

Synonym
sibiricose a6
[(2s,3s,4r,5r)-4-hydroxy-2,5-bis(hydroxymethyl)-2-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxolan-3-yl] (e)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate
CHEMBL3581236
241125-75-7
NCGC00385084-01
ncgc00385084-01_c23h32o15_alpha-d-glucopyranoside, 3-o-[(2e)-3-(4-hydroxy-3,5-dimethoxyphenyl)-1-oxo-2-propen-1-yl]-beta-d-fructofuranosyl
sibiricosea6
HY-N2172
CS-0019481

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019
)
0.51
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (12)

Assay IDTitleYearJournalArticle
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347160Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347159Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1227881Cytotoxicity against human HCT15 cells assessed as cell growth inhibition after 48 hrs by SRB assay2015Bioorganic & medicinal chemistry letters, Jan-01, Volume: 25, Issue:1
Anti-inflammatory and antitumor phenylpropanoid sucrosides from the seeds of Raphanus sativus.
AID1227880Cytotoxicity against human SK-MEL-2 cells assessed as cell growth inhibition after 48 hrs by SRB assay2015Bioorganic & medicinal chemistry letters, Jan-01, Volume: 25, Issue:1
Anti-inflammatory and antitumor phenylpropanoid sucrosides from the seeds of Raphanus sativus.
AID1227877Cytotoxicity against mouse BV2 cells assessed as inhibition of cell viability by MTT assay2015Bioorganic & medicinal chemistry letters, Jan-01, Volume: 25, Issue:1
Anti-inflammatory and antitumor phenylpropanoid sucrosides from the seeds of Raphanus sativus.
AID1227878Cytotoxicity against human A549 cells assessed as cell growth inhibition after 48 hrs by SRB assay2015Bioorganic & medicinal chemistry letters, Jan-01, Volume: 25, Issue:1
Anti-inflammatory and antitumor phenylpropanoid sucrosides from the seeds of Raphanus sativus.
AID1227879Cytotoxicity against human SKOV3 cells assessed as cell growth inhibition after 48 hrs by SRB assay2015Bioorganic & medicinal chemistry letters, Jan-01, Volume: 25, Issue:1
Anti-inflammatory and antitumor phenylpropanoid sucrosides from the seeds of Raphanus sativus.
AID1227875Inhibition of LPS-induced nitric oxide production in mouse BV2 cells treated for 30 mins prior to LPS stimulation for 24 hrs by Griess assay2015Bioorganic & medicinal chemistry letters, Jan-01, Volume: 25, Issue:1
Anti-inflammatory and antitumor phenylpropanoid sucrosides from the seeds of Raphanus sativus.
AID1227882Antioxidant activity assessed as DPPH radical scavenging activity after 10 mins by spectrophotomteric analysis2015Bioorganic & medicinal chemistry letters, Jan-01, Volume: 25, Issue:1
Anti-inflammatory and antitumor phenylpropanoid sucrosides from the seeds of Raphanus sativus.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's3 (50.00)24.3611
2020's2 (33.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.26

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.26 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index5.21 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.26)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]