Botulism

A disease caused by potent protein NEUROTOXINS produced by CLOSTRIDIUM BOTULINUM which interfere with the presynaptic release of ACETYLCHOLINE at the NEUROMUSCULAR JUNCTION. Clinical features include abdominal pain, vomiting, acute PARALYSIS (including respiratory paralysis), blurred vision, and DIPLOPIA. Botulism may be classified into several subtypes (e.g., food-borne, infant, wound, and others). (From Adams et al., Principles of Neurology, 6th ed, p1208)

Synonym
Botulism

Excerpt	Reference
"Botulism is another rare disorder of presynaptic neuromuscular transmission that is most commonly associated with improper storage or preservation of food products."	( Raja, SM, 2022)
"Infant botulism is a rare disease in the UK, with the first case being recognized in 1978 and only five subsequent cases being reported before 2007."	( Courtney, M; Dixon, G; Grant, KA; Lister, P; McLauchlin, J; Mithani, V; Morgan, J; Mpamugo, O; Nixon, G; Nwarfor, I; Planche, T, 2009)
"Botulism is the acute, flaccid paralysis caused by a neurotoxin produced by Clostridium botulinum."	( Formicola, S; Pisanti, A; Pisanti, R; Vitiello, R, 2009)
"Botulism is a disease characterized by neuromuscular paralysis and is produced from botulinum neurotoxins (BoNTs) found within the Gram positive bacterium Clostridium botulinum."	( Di Mola, A; Globisch, D; Hixon, MS; Janda, KD; Kinoyama, I; Zakhari, JS, 2011)
"Botulism is an often fatal intoxication in man, animals, birds and certain fish."	( Bester, L; Greyling, F; Pretorius, D; Venter, L; Williams, JH, 2011)
"Wound botulism is caused by growth of cells and release of toxin in vivo, is associated with traumatic wounds and abscesses and has been reported in drug users, such as those injecting heroin or sniffing cocaine."	( Brett, MM; Hallas, G; Mpamugo, O, 2004)
"Wound botulism is a rare infectious disease due to neurotoxin release from the anaerobic, spore-forming bacterium Clostridium botulinum that is becoming an ever more frequent complication of parenteral drug abuse in the Western world."	( Cooper, JG; Denton, M; Jamieson, S; Spilke, CE, 2005)
"Botulism is an intoxication caused by ingestion of feed or water contaminated with the toxin of Clostridium botulinum."	( Braun, U, 2006)
"Wound botulism is a rare infectious and toxicologic complication of trauma and i."	( Burningham, MD; Ekins, BR; Haber, J; Mechem, C; Walter, FG, 1994)
"Botulism is a rare neuroparalytic disease caused by neurotoxins of Clostridium species."	( Adorján, T; Boros, L; Czeglédi, Z; Farkas, M, 1998)
"Because botulism is rarely seen, most physicians are unfamiliar with its early recognition and treatment."	( Buchmann, T; Kabatnik, M; Peters, J; Sander, A, 1999)
"Botulism is relatively common in the Vienne department as we have observed 36 cases over a peroid of 7 years."	( Becq-Giraudon, B; Boutaud, Ph; Sudre, Y, 1975)
"Although botulism is rare in Australia, clinicians should be aware of the clinical presentation and the rapidity of confirmation of the diagnosis by electrophysiological testing."	( Boyle, RS; Henderson, A; King, MA; Paterson, DL; Pond, SM; Whitby, M; Wright, M, 1992)
"Botulism is widely known to result from ingestion of food containing botulinum neurotoxin produced in situ by certain strains of Clostridium botulinum."	( DasGupta, BR; Giménez, JA; Giménez, MA, 1992)
"Botulism is induced by botulinum toxin and the mechanism of the disease is unknown."	( Chao, LP, 1986)

Excerpt	Reference
"Type C botulism has previously been reported more commonly than type D in the UK and has been associated with the use of poultry litter as fertiliser, bedding or feed."	( Hogg, RA; Livesey, CT; Otter, A; Payne, JH; Roest, HI, 2011)

Excerpt	Reference
"The specific treatments of botulism with serotherapy and with guanidine are of debatable efficacy."	( Ben Ali, A; Carlet, J; Deletie, E; Dock, M; Garrouste-Orgeas, M; Goldstein, F; Karras, A; Misset, B, 2002)
"Aspects of the treatment of botulism in animals are discussed."	( Greenwood, AG, 1985)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	203 (51.92)	23.3326
1990's	51 (13.04)	12.5806
2000's	64 (16.37)	18.1394
2010's	58 (14.83)	28.8240
2020's	15 (3.84)	9.53

Drug	Relationship Strength	Studies	Trials
5-hydroxytryptophan	low	1	0
ethylene glycol	low	1	0
acetic acid	low	1	0
quinacrine	low	1	0
bromide	low	2	0
carbamates	low	3	0
carbon monoxide	low	1	0
choline	low	2	0
citric acid, anhydrous	low	1	0
creatine	low	1	0
lactic acid	low	4	0
formaldehyde	low	3	0
glycine	low	1	0
histamine	low	1	0
iodine	low	2	0
methanol	low	3	0
niacin	low	1	0
nitrates	low	4	0
nitrites	low	10	0
pentachlorophenol	low	1	0
sulfites	low	1	0
sulfur dioxide	low	1	0
thiamine	low	1	0
toluene	low	1	0
urea	low	1	0
1-anilino-8-naphthalenesulfonate	low	1	0
mercaptoethanol	low	1	0
3-aminobenzamide	low	1	0
4-aminopyridine	medium	11	1
phenytoin	low	1	0
hydroxyindoleacetic acid	low	1	0
oxyquinoline	low	1	0
albuterol	low	2	0
aspirin	low	1	0
aurintricarboxylic acid	low	1	0
baclofen	low	1	0
benzamide	low	1	0
verapamil	low	1	0
carbonyl cyanide m-chlorophenyl hydrazone	low	1	0
ciprofloxacin	low	2	0
decamethonium	low	1	0
diazepam	low	1	0
dichlorodiphenyl dichloroethylene	low	1	0
ddt	low	1	0
ebselen	low	1	0
edrophonium	medium	8	1
erythrosine	low	1	0
fenthion	low	1	0
fluphenazine	low	3	0
fluorouracil	low	1	0
gentamicin	low	2	0
glyphosate	low	1	0
guanidine	low	2	0
haloperidol	low	1	0
lidocaine	low	1	0
isoniazid	low	1	0
mescaline	low	1	0
metronidazole	low	4	0
apnea	low	5	0
neostigmine	low	5	0
papaverine	low	1	0
pargyline	low	1	0
perphenazine	low	2	0
potassium chloride	low	1	0
procaine	low	2	0
promethazine	low	1	0
pyridinolcarbamate	low	1	0
succinylcholine	low	1	0
sulfaguanidine	low	1	0
sulfamethoxazole	low	1	0
theobromine	low	1	0
trifluoperazine	low	1	0
trimethoprim	low	1	0
prednisolone	low	2	0
carbachol	low	1	0
spironolactone	low	1	0
penicillin g	low	4	0
pilocarpine	low	1	0
cantharidin	low	1	0
serine	low	1	0
chloramphenicol	low	6	0
cyanides	low	4	0
physostigmine	low	1	0
cephalothin	low	1	0
kanamycin a	low	2	0
galactose	low	2	0
methicillin	low	1	0
cloxacillin	low	1	0
phenylalanine	low	2	0
barbituric acid	low	2	0
chloroform	low	1	0
ampicillin	low	1	0
histidine	low	1	0
threonine	low	1	0
alizarin	low	1	0
methyl bromide	low	1	0
phencyclidine	low	9	0
methylprednisolone	low	1	0
benzoic anhydride	low	1	0
fluorene	low	1	0
n-vinyl-2-pyrrolidinone	low	4	0
propylparaben	low	1	0
pyridostigmine bromide	low	3	0
melamine	low	1	0
2-naphthol	low	1	0
thiamine pyrophosphate	low	4	0
alpha-aminopyridine	low	12	0
echothiophate iodide	low	1	0
hematoxylin	low	1	0
methamphetamine	low	1	0
erythromycin	low	2	0
vancomycin	low	2	0
dithiothreitol	low	1	0
streptomycin	low	1	0
manganese	low	1	0
mercury	low	1	0
silver	low	1	0
gold	low	1	0
mercuric chloride	low	1	0
chlorine	low	1	0
nitrous acid	low	1	0
aluminum sulfate	low	2	0
clonixin	low	1	0
cetylpyridinium chloride anhydrous	low	1	0
4-methoxyamphetamine	low	2	0
calcium oxalate	low	1	0
amoxicillin	low	2	0
acetylgalactosamine	low	1	0
flunixin meglumine	low	1	0
fomesafen	low	3	0
aluminum phosphate	low	1	0
cephalosporin c	low	2	0
4-aminoquinoline	low	1	0
fluorodeoxyglucose f18	low	1	0
nicotine	low	1	0
cadusafos	low	2	0
glycidyl nitrate	low	1	0
prolamins	low	1	0
foxes	low	3	0
hc toxin	low	1	0
toosendanin	low	6	0
atropine	low	2	0
1-methylpropyl-2-imidazolyl disulfide	low	1	0
cortisone	low	1	0
anatoxin a	low	2	0
glycogen	low	1	0
n-acetylneuraminic acid	low	3	0
fibrin	low	1	0
strychnine	low	2	0
meropenem	low	1	0
cefoxitin	low	1	0
indican	low	1	0
cocaine	low	3	0
clindamycin	low	2	0
enkephalin, leucine	low	1	0
sorbic acid	low	2	0
sodium metabisulfite	low	1	0
isopropyl thiogalactoside	low	1	0
dieldrin	low	1	0
thiourea	low	2	0
unithiol	low	1	0
digoxin	low	1	0
guanylthiourea	low	2	0
clavulanic acid	low	1	0
pulmicort	low	1	0
humulene	low	1	0
codeine	low	1	0
morphine	low	1	0
aluminum	low	1	0
bismuth	low	1	0
thallium	low	3	0
arsenic	low	1	0
lasalocid	low	1	0
phosphorus	low	1	0
heroin	low	24	0
cefotaxime	low	1	0
tetrodotoxin	low	1	0
trisialoganglioside gt1	low	5	0
nitrofurantoin	low	1	0
ciclesonide	low	1	0
toosendanin	low	2	0
lactulose	low	1	0
scopolamine hydrobromide	low	1	0
clove	low	2	0
acid phosphatase	low	3	0
peptide i	low	1	0
chlorophyll a	low	1	0
chitosan	low	1	0
sodium nitrite	low	4	0
sodium glutamate	low	1	0
ro13-9904	low	1	0
chiniofon	low	1	0
heme	low	1	0
ascorbic acid	low	1	0
tetracycline	low	2	0
oxytetracycline, anhydrous	low	1	0
sybr green i	low	2	0
agar	low	4	0
vitamin b 12	low	1	0
thromboplastin	low	1	0
muramidase	low	2	0
guanosine	low	1	0
pheophytin a	low	1	0
dyngo-4a	low	1	0
eye	low	2	0
gq1b ganglioside	low	1	0

Protein Targets (1,453)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain B, pheromone binding protein	0	0	1	1
Chain A, pheromone binding protein	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	17	0	0	17
Chain A, RNA-directed RNA polymerase NS5	0	2	0	2
acid sphingomyelinase	3	0	0	3
thioredoxin reductase	33	0	0	33
USP1 protein, partial	20	0	0	20
TDP1 protein	42	0	0	42
vitamin D3 receptor isoform VDRA	17	0	0	17
importin subunit beta-1 isoform 1	8	0	0	8
flap endonuclease 1	16	0	0	16
serine/threonine-protein kinase PLK1	10	0	0	10
snurportin-1	8	0	0	8
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	10	0	0	10
GTP-binding nuclear protein Ran isoform 1	4	0	0	4
DNA polymerase eta isoform 1	9	0	0	9
DNA polymerase iota isoform a (long)	18	0	0	18
urokinase-type plasminogen activator precursor	6	0	0	6
plasminogen precursor	6	0	0	6
urokinase plasminogen activator surface receptor precursor	6	0	0	6
geminin	46	0	0	46
DNA polymerase kappa isoform 1	19	0	0	19
fibroblast growth factor 22 isoform 1 precursor	0	0	0	1
Mitogen-activated protein kinase 13	0	1	0	1
Beta-lactamase	0	2	0	2
Transthyretin	0	1	1	2
Fatty acid-binding protein, intestinal	0	1	1	2
Fatty acid-binding protein, adipocyte	0	1	1	2
Cyclin-A2	0	1	0	1
Cannabinoid receptor 1	0	0	1	1
Cyclin-dependent kinase 2	0	1	1	2
Choline O-acetyltransferase	0	1	0	1
Mitogen-activated protein kinase 12	0	1	0	1
Guanine nucleotide-binding protein G	5	0	0	5
Fatty acid-binding protein 5	0	0	1	1
Fatty acid-binding protein 5	0	0	1	1
Mitogen-activated protein kinase 11	0	1	0	1
Mitogen-activated protein kinase 14	0	2	0	2
Fumarate hydratase	11	0	0	11
EWS/FLI fusion protein	16	0	0	16
polyprotein	11	0	0	11
Spike glycoprotein	0	4	3	7
Replicase polyprotein 1ab	0	4	3	7
Transmembrane protease serine 2	0	4	3	7
Procathepsin L	0	4	3	7
Replicase polyprotein 1a	0	4	3	7
Replicase polyprotein 1ab	0	4	3	7
Replicase polyprotein 1ab	0	5	3	8
Replicase polyprotein 1ab	0	8	3	11
Thioredoxin	0	1	0	1
Spike glycoprotein	18	4	3	25
Angiotensin-converting enzyme 2	0	4	3	7
Luciferase	20	0	0	20
RAR-related orphan receptor gamma	39	0	0	39
GLI family zinc finger 3	48	0	0	48
AR protein	57	0	0	57
estrogen receptor 2 (ER beta)	26	0	0	26
nuclear receptor subfamily 1, group I, member 3	32	0	0	32
progesterone receptor	31	0	0	31
retinoic acid nuclear receptor alpha variant 1	45	0	0	45
retinoid X nuclear receptor alpha	31	0	0	31
pregnane X nuclear receptor	35	0	0	35
estrogen nuclear receptor alpha	66	0	0	66
peroxisome proliferator-activated receptor delta	25	0	0	25
aryl hydrocarbon receptor	29	0	0	29
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	26	0	0	26
v-jun sarcoma virus 17 oncogene homolog (avian)	27	0	0	27
Histone H2A.x	17	0	0	17
thyroid hormone receptor beta isoform 2	39	0	0	39
nuclear factor erythroid 2-related factor 2 isoform 1	44	0	0	44
DNA repair and recombination protein RadA	0	0	1	1
Voltage-dependent calcium channel gamma-2 subunit	25	0	0	25
Cellular tumor antigen p53	34	0	0	34
Cytochrome P450 1A2	0	5	0	5
Cytochrome P450 2A6	0	5	2	7
Sulfotransferase 1A1	0	0	0	1
Glutamate receptor 2	27	0	0	27
Cytochrome P450 2A5	0	2	0	2
Sulfotransferase 1E1	0	0	0	1
Sulfotransferase 1A1	0	0	0	1
Sulfotransferase 2A1	0	0	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	28	0	0	28
Chain A, HADH2 protein	18	0	0	18
Chain B, HADH2 protein	18	0	0	18
Chain A, 2-oxoglutarate Oxygenase	17	0	0	17
Chain A, Ferritin light chain	8	0	0	8
Chain A, Cruzipain	9	0	0	9
aldehyde dehydrogenase 1 family, member A1	34	0	0	34
cytochrome P450 2D6 isoform 1	11	0	0	11
cytochrome P450 2C9 precursor	9	0	0	9
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	14	0	0	14
lamin isoform A-delta10	37	0	0	37
Poly [ADP-ribose] polymerase 2	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	3	0	3
Poly [ADP-ribose] polymerase 1	0	1	0	1
Histamine H2 receptor	16	0	1	19
Transporter	0	5	2	8
ATP-dependent phosphofructokinase	23	0	0	23
Microtubule-associated protein tau	25	0	0	25
thyroid stimulating hormone receptor	30	0	0	30
cytochrome P450 family 3 subfamily A polypeptide 4	33	0	0	33
glucocorticoid receptor [Homo sapiens]	44	0	0	44
cytochrome P450 2D6	17	0	0	17
glucocerebrosidase	12	0	0	12
IDH1	18	0	0	18
euchromatic histone-lysine N-methyltransferase 2	51	0	0	51
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	19	0	0	19
chromobox protein homolog 1	34	0	0	34
transcriptional regulator ERG isoform 3	5	0	0	5
mitogen-activated protein kinase 1	15	0	0	15
peripheral myelin protein 22	19	0	0	19
survival motor neuron protein isoform d	15	0	0	15
lethal factor (plasmid)	24	0	0	24
Potassium channel subfamily K member 2	0	3	3	6
Rap guanine nucleotide exchange factor 3	7	0	0	7
Potassium voltage-gated channel subfamily A member 3	0	1	1	2
Acetylcholinesterase	0	3	0	3
Pteridine reductase 1	0	1	0	1
Potassium voltage-gated channel subfamily A member 1	0	1	1	2
Potassium voltage-gated channel subfamily H member 2	0	22	0	23
Neutrophil cytosol factor 1	0	3	1	4
5-hydroxytryptamine receptor 2C	0	7	4	11
5-hydroxytryptamine receptor 2A	0	10	4	14
5-hydroxytryptamine receptor 1A	0	17	4	22
5-hydroxytryptamine receptor 1B	0	12	2	14
5-hydroxytryptamine receptor 1D	0	4	2	6
5-hydroxytryptamine receptor 1F	0	4	2	6
5-hydroxytryptamine receptor 2B	0	7	3	10
5-hydroxytryptamine receptor 6	0	1	2	3
Sodium-dependent serotonin transporter	0	12	2	14
Sodium-dependent serotonin transporter	0	9	0	10
5-hydroxytryptamine receptor 7	0	3	2	5
5-hydroxytryptamine receptor 5A	0	1	2	3
5-hydroxytryptamine receptor 5B	0	1	2	3
5-hydroxytryptamine receptor 3A	0	1	2	3
5-hydroxytryptamine receptor 4	0	1	2	3
5-hydroxytryptamine receptor 3B	0	1	2	3
dopamine D1 receptor	5	0	0	5
NFKB1 protein, partial	12	0	0	12
GLS protein	29	0	0	29
nonstructural protein 1	9	0	0	9
bromodomain adjacent to zinc finger domain 2B	16	0	0	16
Gamma-aminobutyric acid receptor subunit pi	25	6	2	34
5-hydroxytryptamine receptor 1A	0	4	0	4
Gamma-aminobutyric acid receptor subunit beta-1	25	6	2	34
Gamma-aminobutyric acid receptor subunit delta	25	6	2	34
Gamma-aminobutyric acid receptor subunit gamma-2	25	6	3	35
Gamma-aminobutyric acid receptor subunit alpha-5	25	6	2	34
Gamma-aminobutyric acid receptor subunit alpha-3	25	6	2	34
Gamma-aminobutyric acid receptor subunit gamma-1	25	6	2	34
Gamma-aminobutyric acid receptor subunit alpha-2	25	6	2	34
5-hydroxytryptamine receptor 1D	0	1	0	3
5-hydroxytryptamine receptor 1B	0	3	1	4
5-hydroxytryptamine receptor 2A	0	15	2	17
5-hydroxytryptamine receptor 2C	0	14	1	15
Gamma-aminobutyric acid receptor subunit alpha-4	25	6	2	34
Gamma-aminobutyric acid receptor subunit gamma-3	25	6	2	34
Gamma-aminobutyric acid receptor subunit alpha-6	25	6	2	34
Cholecystokinin receptor type A	0	2	1	3
Gastrin/cholecystokinin type B receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	4	1	5
5-hydroxytryptamine receptor 6	0	8	1	9
Gamma-aminobutyric acid receptor subunit alpha-1	25	7	3	36
Gamma-aminobutyric acid receptor subunit beta-3	25	6	2	34
Gamma-aminobutyric acid receptor subunit beta-2	25	6	3	35
Fatty-acid amide hydrolase 1	0	1	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
Transient receptor potential cation channel subfamily M member 8	0	1	0	1
GABA theta subunit	25	6	2	34
Gamma-aminobutyric acid receptor subunit epsilon	25	6	2	34
Free fatty acid receptor 3	0	0	1	1
Free fatty acid receptor 2	0	1	1	2
Tyrosine-protein kinase Lck	0	0	1	1
Tyrosine-protein kinase Fyn	0	1	1	2
Fibrinogen C domain-containing protein 1	0	2	0	2
glp-1 receptor, partial	15	0	0	15
regulator of G-protein signaling 4	25	0	0	25
estrogen-related nuclear receptor alpha	47	0	0	47
NPYLR7B	0	0	2	2
arylsulfatase A	16	0	0	16
thyroid stimulating hormone receptor	20	0	0	20
ATP-binding cassette sub-family C member 3	0	34	0	34
Multidrug resistance-associated protein 4	0	34	0	34
Bile salt export pump	0	53	0	53
Beta-2 adrenergic receptor	0	4	3	7
Beta-1 adrenergic receptor	0	2	3	5
60 kDa chaperonin	0	3	0	3
60 kDa heat shock protein, mitochondrial	0	5	0	5
Beta-3 adrenergic receptor	0	4	2	6
Delta-type opioid receptor	0	6	2	9
10 kDa heat shock protein, mitochondrial	0	5	0	5
Thiosulfate sulfurtransferase	0	5	0	5
Beta-2 adrenergic receptor	0	0	1	3
60 kDa chaperonin	0	6	0	6
10 kDa chaperonin	0	6	0	6
Beta-2 adrenergic receptor	0	3	3	7
Canalicular multispecific organic anion transporter 1	0	33	0	33
Chain A, ATP-DEPENDENT DNA HELICASE Q1	10	0	0	10
endonuclease IV	12	0	0	12
15-lipoxygenase, partial	11	0	0	11
WRN	4	0	0	4
G	17	0	0	17
peroxisome proliferator activated receptor gamma	28	0	0	28
polyunsaturated fatty acid lipoxygenase ALOX12	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 2	8	0	0	9
potassium voltage-gated channel subfamily H member 2 isoform d	20	0	0	20
histone deacetylase 9 isoform 3	4	0	0	4
tumor susceptibility gene 101 protein	2	0	0	2
dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	0	1
Vpr	5	0	0	5
cytochrome P450 3A4 isoform 1	25	0	0	25
histone acetyltransferase KAT2A isoform 1	20	0	0	20
kelch-like ECH-associated protein 1	0	0	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	10	0	0	10
Interferon beta	23	0	0	23
HLA class I histocompatibility antigen, B alpha chain	17	0	0	17
Gag-Pol polyprotein	0	1	0	1
Apoptosis regulator Bcl-2	0	1	0	1
D(3) dopamine receptor	0	5	0	5
Glutamate receptor 1	2	0	0	2
Glutamate receptor 3	2	0	0	2
Glutamate receptor 4	2	0	0	2
Amine oxidase [flavin-containing] A	0	3	0	3
Amine oxidase [flavin-containing] B	0	5	1	6
Inositol monophosphatase 1	11	0	0	11
Induced myeloid leukemia cell differentiation protein Mcl-1	0	1	0	1
TAR DNA-binding protein 43	8	0	0	8
Cytochrome P450 1B1	0	2	0	2
RmtA	0	1	0	1
Reverse transcriptase/RNaseH	0	1	0	2
Inositol hexakisphosphate kinase 1	17	0	0	17
Protein arginine N-methyltransferase 1	0	1	0	1
cytochrome P450 2C9, partial	17	0	0	17
phosphoglycerate kinase	5	0	0	5
Heat shock protein HSP 90-alpha	0	0	1	1
Botulinum neurotoxin type A	0	2	0	2
Nitric oxide synthase, endothelial	0	1	0	1
Nitric oxide synthase, brain	0	1	0	1
Nitric oxide synthase, brain	0	1	0	1
Nitric oxide synthase, inducible	0	1	0	1
Kappa-type opioid receptor	0	6	1	11
Phosphatidylinositol 4-kinase alpha	0	1	0	1
Mu-type opioid receptor	0	6	1	7
Tyrosine-protein kinase	0	0	1	1
Phosphatidylinositol 4-kinase type 2-beta	0	1	0	1
Phosphatidylinositol 4-kinase type 2-alpha	0	1	0	1
Phosphatidylinositol 4-kinase beta	0	1	0	1
Chain A, Beta-lactamase	20	0	0	20
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	6	0	0	6
POU domain, class 2, transcription factor 1	0	0	0	2
Beta-lactamase	0	1	0	4
Beta-lactamase	0	1	0	5
Beta-lactamase	0	0	0	6
Beta-lactamase	0	1	0	6
apical membrane antigen 1, AMA1	9	0	0	9
Beta-lactamase	0	0	0	3
Bile salt export pump	0	10	0	10
Beta-lactamase SHV-1	0	1	0	5
Beta-lactamase SHV-1	0	2	0	7
Cytochrome P450 2C9	0	13	1	14
Beta-lactamase	0	1	0	7
Solute carrier family 15 member 1	0	8	0	8
Solute carrier family 15 member 1	0	2	0	2
Cytochrome P450 2J2	0	9	0	9
B2 metallo-beta-lactamase	0	0	0	5
Solute carrier family 15 member 2	0	6	0	6
Beta-lactamase	0	1	0	5
Beta-lactamase	0	1	0	5
Solute carrier family 15 member 2	0	6	0	6
Beta-lactamase	0	1	0	5
Beta-lactamase	0	0	0	5
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Beta-lactamase	0	1	0	5
farnesoid X nuclear receptor	23	0	0	23
Beta-lactamase	0	3	0	6
Beta-lactamase	0	0	0	5
Metallo-beta-lactamase type 2	0	0	1	7
Metallo-beta-lactamase VIM-11	0	0	0	6
Metallo-beta-lactamase VIM-2	0	0	0	6
Beta-lactamase	0	0	0	5
Metallo-beta-lactamase	0	0	0	6
Beta-lactamase	0	3	0	6
DNA polymerase beta	9	0	0	9
Carbonic anhydrase 1	0	12	0	16
Carbonic anhydrase 2	0	13	0	18
Beta-lactamase OXA-7	0	0	0	2
Angiopoietin-1 receptor	0	0	1	1
Beta-lactamase	0	1	0	5
Beta-lactamase	0	1	0	5
Beta-lactamase	0	1	0	5
Metallo-beta-lactamase VIM-13	0	0	0	5
Efflux transporter	0	1	0	4
Beta-lactamase	0	0	0	5
Beta-lactamase Toho-1	0	0	0	4
Beta-lactamase	0	1	0	4
Class D beta-lactamase	0	1	0	3
Metallo-beta-lactamase	0	0	0	5
Beta-lactamase	0	1	0	6
Beta-lactamase	0	0	1	4
Metallo-b-lactamase	0	0	0	8
Carbapenem-hydrolyzing beta-lactamase KPC	0	2	0	8
Histamine H3 receptor	0	1	0	6
Beta-lactamase class B VIM-2	0	1	1	10
Beta-lactamase VIM-1	0	0	0	5
Acetylcholine receptor subunit alpha	0	3	1	4
Acetylcholine receptor subunit beta	0	3	1	4
Acetylcholine receptor subunit gamma	0	3	1	4
Acetylcholine receptor subunit delta	0	3	1	4
Neuronal acetylcholine receptor subunit alpha-3	0	6	3	10
Neuronal acetylcholine receptor subunit alpha-4	2	7	3	13
Neuronal acetylcholine receptor subunit alpha-2	0	5	3	9
Neuronal acetylcholine receptor subunit beta-2	2	7	3	13
Neuronal acetylcholine receptor subunit beta-3	0	5	3	9
Neuronal acetylcholine receptor subunit beta-4	0	6	3	10
Neuronal acetylcholine receptor subunit beta-2	0	3	1	4
Neuronal acetylcholine receptor subunit alpha-5	0	5	3	9
Neuronal acetylcholine receptor subunit alpha-6	0	5	3	9
Neuronal acetylcholine receptor subunit alpha-9	0	5	3	9
Neuronal acetylcholine receptor subunit alpha-4	0	3	1	4
Neuronal acetylcholine receptor subunit alpha-7	0	7	3	11
Neuronal acetylcholine receptor subunit alpha-10	0	5	3	9
ATAD5 protein, partial	17	0	0	17
Bloom syndrome protein isoform 1	11	0	0	11
D(1A) dopamine receptor	12	0	0	12
neuropeptide S receptor isoform A	5	0	0	5
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	22	0	0	22
thioredoxin glutathione reductase	8	0	0	8
vitamin D (1,25- dihydroxyvitamin D3) receptor	27	0	0	27
lethal(3)malignant brain tumor-like protein 1 isoform I	7	0	0	7
Polyphenol oxidase 2	0	4	0	4
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	3	0	4
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	8	2	11
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	16	0	0	16
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	12	0	0	12
hypothetical protein, conserved	5	0	0	5
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
muscarinic acetylcholine receptor M1	19	0	0	19
Prostaglandin-H2 D-isomerase	0	1	0	1
Solute carrier family 22 member 6	0	4	0	4
Prostaglandin G/H synthase 1	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	1
Epidermal growth factor receptor	0	3	0	3
Fatty acid-binding protein, liver	0	3	0	3
Integrin beta-3	7	1	0	8
Myeloperoxidase	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	7	1	0	8
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Adenosine receptor A1	0	5	0	9
Adenosine receptor A2a	0	4	0	9
Substance-P receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	3	0	3
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	12	1	1	14
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Sigma non-opioid intracellular receptor 1	1	15	1	17
Sigma non-opioid intracellular receptor 1	0	4	1	5
cystic fibrosis transmembrane conductance regulator	0	2	0	2
short transient receptor potential channel 6 isoform 1	0	0	1	1
Solute carrier family 22 member 1	0	11	0	15
5-hydroxytryptamine receptor 4	0	12	0	12
Muscarinic acetylcholine receptor M2	0	15	5	24
Muscarinic acetylcholine receptor M4	0	13	3	19
Muscarinic acetylcholine receptor M1	0	14	3	22
Muscarinic acetylcholine receptor M3	0	12	3	19
Muscarinic acetylcholine receptor M4	0	13	2	19
Muscarinic acetylcholine receptor M5	0	12	2	18
Muscarinic acetylcholine receptor M5	0	12	3	18
Muscarinic acetylcholine receptor M2	0	14	3	22
Muscarinic acetylcholine receptor M1	0	16	6	26
Muscarinic acetylcholine receptor M1	0	1	3	6
Muscarinic acetylcholine receptor M3	0	13	4	20
Alpha-1D adrenergic receptor	0	10	1	12
Muscarinic acetylcholine receptor M4	0	2	1	4
5-hydroxytryptamine receptor 7	0	8	0	8
Muscarinic acetylcholine receptor	0	4	1	6
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	12	0	0	12
RGS12	2	0	0	2
ClpP	2	0	0	2
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
Thrombopoietin	10	0	0	10
DNA polymerase III, partial	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	8	0	0	8
galactokinase	1	0	0	1
hexokinase-4 isoform 1	4	0	0	4
peripheral myelin protein 22 isoform 1	11	0	0	11
cytochrome P450 2C19 precursor	9	0	0	9
runt-related transcription factor 1 isoform AML1b	1	0	0	1
thyroid hormone receptor beta isoform a	16	0	0	16
glucokinase regulatory protein	4	0	0	4
core-binding factor subunit beta isoform 2	1	0	0	1
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	9	0	0	9
eyes absent homolog 2 isoform a	2	0	0	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
M-phase phosphoprotein 8	13	0	0	13
pyruvate kinase PKM isoform b	2	0	0	2
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	1	0	1
Myc proto-oncogene protein	0	1	0	1
Complement component C9	0	1	0	1
Ornithine decarboxylase	2	0	0	2
Cruzipain	0	1	0	1
DNA-(apurinic or apyrimidinic site) endonuclease	0	1	0	1
DNA-3-methyladenine glycosylase	0	1	0	1
Ribonuclease T	0	0	0	2
Cystathionine gamma-lyase	0	2	1	4
Mu-type opioid receptor	0	8	1	12
Cystathionine beta-synthase	0	1	0	1
Alpha-synuclein	3	1	0	4
DNA repair protein RAD52 homolog	0	1	0	1
Dual specificity mitogen-activated protein kinase kinase 3	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	5	0	0	5
Cell death-related nuclease 4	0	0	0	2
Cystathionine gamma-lyase	0	1	0	1
Single-stranded DNA cytosine deaminase	1	0	0	1
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
DNA polymerase iota	0	1	0	1
DNA polymerase eta	0	1	0	1
Cysteine protease ATG4B	0	1	0	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	3	0	0	3
large T antigen	0	4	0	4
phosphopantetheinyl transferase	18	0	0	18
67.9K protein	11	0	0	11
activating transcription factor 6	22	0	0	22
Gamma-aminobutyric acid type B receptor subunit 2	0	2	1	3
Gamma-aminobutyric acid type B receptor subunit 2	0	2	0	2
Gamma-aminobutyric acid type B receptor subunit 1	0	2	1	3
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Coagulation factor VII	0	1	0	1
Tissue factor	0	1	0	1
Nicotinamide N-methyltransferase	0	1	0	1
Poly(ADP-ribose) glycohydrolase	0	1	0	1
Aldo-keto reductase family 1 member C3	0	1	0	1
Carbonic anhydrase 4	0	7	0	10
Carbonic anhydrase	0	6	0	9
Carbonic anhydrase 15	0	4	0	7
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Chitinase	0	1	0	1
atrial natriuretic peptide receptor 1 precursor	6	0	0	6
nuclear receptor ROR-gamma isoform 1	18	0	0	18
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	1	0	1
Cholinesterase	0	7	0	7
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Adenosine receptor A3	0	4	1	5
Acetylcholinesterase	0	14	0	15
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	3	0	3
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	3	2	6
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2b	0	3	0	4
Adenosine receptor A1	0	1	1	4
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	2	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	2	0	2
Serine/threonine-protein kinase ATR	0	2	0	2
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	2	3
Endochitinase B1	0	1	0	1
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	4	2	6
Guanine deaminase	0	1	0	1
PPM1D protein	7	0	0	7
cellular tumor antigen p53 isoform a	9	0	0	9
Protein phosphatase 1B	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	1
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	0	1	0	1
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B	0	1	0	1
GALC protein	3	0	0	3
thyrotropin-releasing hormone receptor	7	0	0	7
Delta-type opioid receptor	0	7	1	12
Sigma non-opioid intracellular receptor 1	0	1	1	2
Muscarinic acetylcholine receptor M3	0	0	2	5
Muscarinic acetylcholine receptor M2	0	0	1	5
Chain A, PAPAIN	1	0	0	1
hypoxia-inducible factor 1 alpha subunit	16	0	0	16
SMAD family member 2	11	0	0	11
SMAD family member 3	11	0	0	11
heat shock protein beta-1	12	0	0	12
ATPase family AAA domain-containing protein 5	14	0	0	14
Ataxin-2	21	0	0	21
CDGSH iron-sulfur domain-containing protein 1	0	4	0	4
Beta-lactamase	0	2	0	5
Beta-lactamase	0	1	0	4
Metallo-beta-lactamase VIM-19	0	0	0	4
Beta-lactamase	0	1	0	4
Albumin	0	0	6	7
Beta-lactamase	0	0	0	2
Beta-lactamase	0	1	0	4
Metallo-beta-lactamase VIM-2	0	0	0	5
Solute carrier family 22 member 6	0	2	0	2
Solute carrier family 22 member 7	0	2	0	2
BlaVIM-1	0	0	0	4
Beta-lactamase	0	0	0	2
Solute carrier family 22 member 8	0	3	0	4
Beta-lactamase	0	1	0	4
Solute carrier family 22 member 11	0	2	0	3
Solute carrier family 22 member 8	0	3	0	4
Solute carrier family 22 member 7	0	2	0	3
Solute carrier family 22 member 8	0	5	0	7
DNA (cytosine-5)-methyltransferase 1 isoform b	0	1	0	1
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1	0	1	0	1
Beta-lactamase	0	1	0	3
Beta-lactamase	0	1	0	4
Beta-lactamase OXA-1	0	1	0	2
Beta-lactamase TEM	0	4	0	8
Beta-lactamase	0	0	0	2
caspase 7, apoptosis-related cysteine protease	8	0	0	8
caspase-3	8	0	0	8
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	4	0	0	4
Caspase-2	0	0	1	1
streptokinase A precursor	0	0	6	6
Dihydroxyacetone phosphate acyltransferase	0	0	0	2
30S ribosomal protein S6	0	3	1	4
30S ribosomal protein S7	0	3	1	4
50S ribosomal protein L15	0	3	1	4
Cytochrome P450 3A4	0	12	1	14
50S ribosomal protein L10	0	3	1	4
50S ribosomal protein L11	0	3	1	4
50S ribosomal protein L7/L12	0	3	1	4
50S ribosomal protein L19	0	3	1	4
50S ribosomal protein L1	0	3	1	4
50S ribosomal protein L20	0	3	1	4
50S ribosomal protein L27	0	3	1	4
50S ribosomal protein L28	0	3	1	4
50S ribosomal protein L29	0	3	1	4
50S ribosomal protein L31	0	3	1	4
50S ribosomal protein L31 type B	0	3	1	4
50S ribosomal protein L32	0	3	1	4
50S ribosomal protein L33	0	3	1	4
50S ribosomal protein L34	0	3	1	4
50S ribosomal protein L35	0	3	1	4
50S ribosomal protein L36	0	3	1	4
30S ribosomal protein S10	0	3	1	4
30S ribosomal protein S11	0	3	1	4
30S ribosomal protein S12	0	3	1	4
30S ribosomal protein S13	0	3	1	4
30S ribosomal protein S16	0	3	1	4
30S ribosomal protein S18	0	3	1	4
30S ribosomal protein S19	0	3	1	4
30S ribosomal protein S20	0	3	1	4
30S ribosomal protein S2	0	3	1	4
30S ribosomal protein S3	0	3	1	4
30S ribosomal protein S4	0	3	1	4
30S ribosomal protein S5	0	3	1	4
30S ribosomal protein S8	0	3	1	4
30S ribosomal protein S9	0	3	1	4
50S ribosomal protein L13	0	3	1	4
50S ribosomal protein L14	0	3	1	4
50S ribosomal protein L16	0	3	1	4
50S ribosomal protein L23	0	3	1	4
30S ribosomal protein S15	0	3	1	4
50S ribosomal protein L17	0	3	1	4
50S ribosomal protein L21	0	3	1	4
50S ribosomal protein L30	0	3	1	4
50S ribosomal protein L6	0	3	1	4
30S ribosomal protein S14	0	3	1	4
30S ribosomal protein S17	0	3	1	4
30S ribosomal protein S1	0	3	1	4
50S ribosomal protein L18	0	3	1	4
50S ribosomal protein L2	0	3	1	4
50S ribosomal protein L3	0	3	1	4
50S ribosomal protein L24	0	3	1	4
50S ribosomal protein L4	0	3	1	4
50S ribosomal protein L22	0	3	1	4
50S ribosomal protein L5	0	3	1	4
30S ribosomal protein S21	0	3	1	4
50S ribosomal protein L25	0	3	1	4
50S ribosomal protein L36 2	0	3	1	4
Methionine--tRNA ligase, mitochondrial	0	0	1	1
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	0	0	2
Solute carrier family 22 member 2	0	1	0	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	0	0	1
Solute carrier family 22 member 1	0	7	0	10
High affinity choline transporter 1	0	1	0	1
Solute carrier family 22 member 2	0	6	0	9
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit A	0	2	0	4
DNA gyrase subunit B	0	2	0	4
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	2
Cytochrome P450 2D6	0	4	0	4
DNA topoisomerase 2-alpha	0	1	0	4
DNA gyrase subunit A	0	1	0	2
Cytochrome P450 2C19	0	6	0	7
Multidrug resistance protein MdtK	0	0	1	1
DNA gyrase subunit B	0	2	0	2
DNA gyrase subunit A	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	4
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
perilipin-5	0	2	0	2
perilipin-1	0	2	0	2
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	2	0	2
Beta-lactamase	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
3-dehydroquinate dehydratase	0	0	1	1
ATP-citrate synthase	0	0	0	1
3-dehydroquinate dehydratase	0	0	1	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Beta-lactamase	0	1	0	1
Neutrophil elastase	0	1	0	1
Cytochrome P450 2B6	0	2	0	2
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Protein-arginine deiminase type-4	0	6	0	6
UDP-glucuronosyltransferase 2B7	0	2	0	5
UDP-glucuronosyltransferase 1A3	0	0	0	2
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	1	0	1
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	4	0	4
Gamma-aminobutyric acid receptor subunit delta	0	4	0	4
Amyloid-beta precursor protein	2	2	0	4
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	1	2
Tryptophan 5-hydroxylase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	4	2	6
Gamma-aminobutyric acid receptor subunit beta-1	0	4	0	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	4	1	5
D	0	3	0	3
Alpha-2B adrenergic receptor	0	3	1	4
Alpha-2C adrenergic receptor	0	3	1	4
Alpha-2A adrenergic receptor	0	3	1	4
Liver carboxylesterase 1	0	0	0	2
Sodium-dependent noradrenaline transporter	0	10	1	11
Sodium-dependent dopamine transporter	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-3	0	4	1	5
Gamma-aminobutyric acid receptor subunit alpha-5	0	4	2	6
Gamma-aminobutyric acid receptor subunit alpha-3	0	4	1	5
Glutamate receptor ionotropic, NMDA 1	1	6	1	11
Lysosomal Pro-X carboxypeptidase	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	4	1	5
Gamma-aminobutyric acid receptor subunit beta-2	0	4	1	5
Gamma-aminobutyric acid receptor subunit alpha-4	0	4	0	4
D(2) dopamine receptor	0	5	1	6
Gamma-aminobutyric acid receptor subunit epsilon	0	4	0	4
Glutamate receptor ionotropic, NMDA 2A	1	6	1	11
Glutamate receptor ionotropic, NMDA 2B	1	6	1	11
Glutamate receptor ionotropic, NMDA 2C	1	6	1	12
Sodium-dependent dopamine transporter	0	4	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
Leukotriene B4 receptor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	4	0	4
Sodium-dependent dopamine transporter	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	1	6	1	11
Gamma-aminobutyric acid receptor subunit gamma-1	0	4	0	4
Glutamate receptor ionotropic, NMDA 3B	1	6	1	11
Gamma-aminobutyric acid receptor subunit gamma-3	0	4	0	4
Leukotriene B4 receptor 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	1	6	1	11
Gamma-aminobutyric acid receptor subunit theta	0	4	0	4
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
Kappa-type opioid receptor	0	4	1	7
Mu-type opioid receptor	0	13	5	19
Delta-type opioid receptor	0	8	3	12
Kappa-type opioid receptor	0	8	3	12
Mu-type opioid receptor	0	4	1	8
Cytochrome P450 2D4	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	2	2
pregnane X receptor	5	0	0	5
Glucocorticoid receptor	0	10	3	18
Sex hormone-binding globulin	0	0	1	1
Glycine receptor subunit alpha-1	0	11	0	11
Corticosteroid-binding globulin	0	2	0	2
Glycine receptor subunit beta	0	10	0	10
Glycine receptor subunit alpha-2	0	10	0	10
Glycine receptor subunit alpha-3	0	10	0	10
Multidrug and toxin extrusion protein 1	0	5	0	5
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Proton-coupled amino acid transporter 1	0	3	0	3
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
Caspase-7	5	0	0	5
caspase-3	5	0	0	5
nuclear factor NF-kappa-B p105 subunit isoform 1	3	0	0	3
Androgen receptor	0	13	0	14
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	4	0	4
Neuronal acetylcholine receptor subunit beta-4	0	3	1	4
Neuronal acetylcholine receptor subunit alpha-3	0	3	1	4
Histamine H3 receptor	0	3	2	5
Gamma-aminobutyric acid	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	5	0	5
Alpha-1-acid glycoprotein 1	0	0	0	1
Albumin	0	0	3	3
ATP-dependent translocase ABCB1	0	17	2	29
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Translocator protein	0	2	2	5
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1S	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1C	0	7	0	7
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	0	2
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Sphingosine-1-phosphate lyase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
serine-protein kinase ATM isoform a	3	0	0	3
PAX8	0	0	0	1
STAT3, partial	0	1	0	1
Smad3	9	0	0	9
alpha-galactosidase	4	0	0	4
NPC intracellular cholesterol transporter 1 precursor	4	0	0	4
tumor necrosis factor	1	0	0	1
ras-related protein Rab-9A	5	0	0	5
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	2
Sodium/potassium-transporting ATPase subunit alpha-1	0	3	0	3
Sodium/potassium-transporting ATPase subunit beta-1	0	3	0	3
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
ATP-dependent translocase ABCB1	0	6	0	6
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-2	0	2	0	2
ATP-dependent translocase ABCB1	0	6	0	7
Sodium/potassium-transporting ATPase subunit alpha-2	0	3	0	3
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	2	0	2
Sodium/potassium-transporting ATPase subunit gamma	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-4	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Solute carrier organic anion transporter family member 1B3	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	3	0	3
RNA polymerase beta subunit (EC 2.7.7.6), partial	0	1	0	1
Nrf2	1	0	0	1
Arrestin, beta 1	0	1	0	1
MPI protein	0	2	0	2
isocitrate dehydrogenase 1, partial	2	0	0	2
luciferase	2	0	0	2
pyruvate kinase	2	0	0	2
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	2	0	2
TPA: protein transporter TIM10	0	1	0	1
TPA: protein transporter TIM23	0	1	0	1
hexokinase	0	1	0	1
hexokinase-1 isoform HKI	0	0	1	1
neutrophil cytosol factor 1	0	1	0	1
phosphomannomutase 2	0	1	0	1
glucose-6-phosphate 1-dehydrogenase isoform b	0	2	0	2
fructose-bisphosphate aldolase A	1	0	0	1
phosphoethanolamine/phosphocholine phosphatase isoform 1	0	1	0	1
huntingtin isoform 2	5	0	0	5
pyruvate kinase PKM isoform a	2	0	0	2
atrial natriuretic peptide receptor 2 precursor	4	0	0	4
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	2	0	2
serine/threonine-protein kinase mTOR isoform 1	8	0	0	8
eukaryotic translation initiation factor 4E isoform 1	0	2	0	2
transient receptor potential cation channel subfamily V member 1	3	0	0	3
hexokinase HKDC1	0	0	1	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	3	0	0	3
Sulfhydryl oxidase 1	0	1	0	1
Acetylcholinesterase	0	7	0	8
Gamma-butyrobetaine dioxygenase	0	1	1	2
Sodium channel protein type 1 subunit alpha	1	1	0	2
Sodium channel protein type 2 subunit alpha	1	2	0	3
Sodium channel protein type 3 subunit alpha	1	1	0	2
Macrophage migration inhibitory factor	0	5	0	5
Insulin-degrading enzyme	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Urease subunit alpha	0	4	0	4
Toxin B	0	1	0	1
Endothelin receptor type B	2	0	0	2
Endothelin-1 receptor	2	1	0	3
Caspase-1	0	1	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Methionine aminopeptidase 2	0	2	0	2
Urease subunit beta	0	4	0	4
Cholinesterase	0	6	0	7
UDP-glucose 4-epimerase	0	1	0	1
Structural capsid protein	0	1	0	1
Histone-lysine N-methyltransferase EHMT2	0	1	0	1
Histone-lysine N-methyltransferase EHMT1	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	1	0	1
hypothetical protein CAALFM_CR05890CA	0	0	0	2
H3 histone acetyltransferase	0	0	0	2
Opioid receptor, delta 1b	0	2	0	2
Opioid receptor homologue	0	2	0	2
Proenkephalin-B	0	0	1	1
Kappa-type opioid receptor	0	4	1	6
Mu-type opioid receptor	0	2	0	2
Motilin receptor	0	0	1	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
Motilin receptor	0	1	1	2
Chitinase B	0	1	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Lanosterol 14-alpha demethylase	0	2	0	2
Genome polyprotein	0	1	1	2
relaxin receptor 1 isoform 1	1	0	0	1
Flavin reductase (NADPH)	0	0	1	1
glycogen synthase kinase-3 alpha	0	0	0	1
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Skn7p	0	0	0	1
hemoglobin subunit beta	2	0	0	2
muscleblind-like protein 1 isoform 1	6	0	0	6
Thymidylate synthase	0	1	0	1
Aromatase	0	1	0	1
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	2
NADPH oxidase 1	0	3	0	3
Snq2p	0	0	0	4
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Aldo-keto reductase family 1 member B1	0	8	0	8
Alpha-2A adrenergic receptor	0	12	3	16
Angiotensin-converting enzyme	0	7	0	7
D(2) dopamine receptor	0	8	2	12
Alpha-1B adrenergic receptor	0	9	1	10
Alpha-2C adrenergic receptor	0	9	2	12
Substance-K receptor	0	2	0	2
D(1A) dopamine receptor	0	7	1	9
D(4) dopamine receptor	0	4	1	7
D(1B) dopamine receptor	0	3	0	4
Histamine H2 receptor	0	11	2	13
Trypanothione reductase	0	8	0	8
Melanocortin receptor 5	0	2	0	2
Pleiotropic ABC efflux transporter of multiple drugs	0	4	0	8
Histamine H1 receptor	0	8	2	10
D(3) dopamine receptor	0	10	1	13
5-hydroxytryptamine receptor 2B	0	11	1	12
Alpha-1A adrenergic receptor	0	9	1	10
D(1A) dopamine receptor	5	1	0	6
Nuclear receptor subfamily 3 group C member 3	0	6	0	6
Beta-galactosidase	0	1	0	1
Lipopolysaccharide heptosyltransferase 1	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Jacalin	0	0	1	1
Glycine receptor subunit alpha-1	0	2	1	3
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	3	0	4
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	2	2
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase	0	1	0	1
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase	0	1	0	1
Glutamine synthetase	0	1	0	1
Cytochrome P450 71B1	0	1	0	2
Glutamine synthetase	0	1	0	1
2-dehydro-3-deoxyphosphooctonate aldolase	0	1	0	1
Solute carrier family 22 member 3	0	3	0	4
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Purine nucleoside phosphorylase	0	0	0	1
Adenosylhomocysteinase	0	1	0	2
Adenylate cyclase type 1	0	1	0	1
Cocaine esterase	0	1	0	1
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	4
UDP-glucuronosyltransferase 1A9	0	1	0	2
Major prion protein	0	0	3	3
Vitamin D-binding protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Integrin beta-1	0	1	0	1
Beta-2 adrenergic receptor	0	4	0	5
Integrin alpha-4	0	1	0	1
Carbonyl reductase [NADPH] 1	0	0	0	1
Beta-1 adrenergic receptor	0	3	1	5
D(2) dopamine receptor	0	2	0	2
Adenylate cyclase type 3	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	2
Alpha-1D adrenergic receptor	0	7	1	8
5-hydroxytryptamine receptor 3A	0	1	0	1
D(1B) dopamine receptor	0	2	0	2
Beta-3 adrenergic receptor	0	3	0	3
Adenylate cyclase type 2	0	1	0	1
Adenylate cyclase type 4	0	1	0	1
D(4) dopamine receptor	0	2	0	2
Histamine H1 receptor	0	4	1	5
C-8 sterol isomerase	0	2	0	2
5-hydroxytryptamine receptor 2C	0	1	0	1
Alpha-1A adrenergic receptor	0	2	2	5
5-hydroxytryptamine receptor 2A	0	1	0	1
Alpha-1B adrenergic receptor	0	1	1	3
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 4 subunit alpha	0	3	0	4
Adenylate cyclase type 8	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
D(2) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
AP-2 complex subunit sigma	0	1	0	1
N-acetyltransferase Eis	0	2	0	2
Sodium channel protein type 7 subunit alpha	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
Adenylate cyclase type 6	0	1	0	1
Adenylate cyclase type 5	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	5	0	5
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	2	0	2
Sodium channel protein type 9 subunit alpha	0	4	0	4
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Zinc finger protein 664	0	1	0	1
Vesicular acetylcholine transporter	0	1	0	1
Transporter	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Protease	0	3	1	4
Adenylyl cyclase 7	0	1	0	1
D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Transient receptor potential cation channel subfamily V member 4	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	3	0	3
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
Chain E, Fibrin beta chain	0	1	0	1
Mcl-1	0	2	0	2
Cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0	0	0	1
alkaline phosphatase, intestinal	0	0	1	1
CDK5	0	0	0	1
lysosomal alpha-glucosidase preproprotein	4	0	0	4
major prion protein preproprotein Prp precursor	0	1	0	1
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	0	1	1
intestinal alkaline phosphatase precursor	0	0	1	1
Vif	0	1	0	1
Tat	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	4	1	0	5
alkaline phosphatase, germ cell type preproprotein	0	0	1	1
endoribonuclease toxin MazF	0	0	1	1
Pyruvate kinase PKM	0	1	1	2
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Carbonic anhydrase 12	0	0	0	3
Plasma kallikrein	0	0	0	3
Carbonic anhydrase 3	0	0	0	3
Carbonic anhydrase 6	0	2	0	5
Histamine H1 receptor	0	1	3	4
Metabotropic glutamate receptor 5	0	2	1	3
Carbonic anhydrase 5A, mitochondrial	0	4	0	7
Carbonic anhydrase 7	0	1	0	4
Carbonic anhydrase	0	0	0	4
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	3	0	3
Carbonic anhydrase 9	0	1	0	4
Carbonic anhydrase	0	0	0	4
Carbonic anhydrase-like protein, putative	0	0	0	3
Carbonic anhydrase	0	1	0	5
Carbonic anhydrase	0	0	0	4
Carbonic anhydrase	0	0	0	4
Equilibrative nucleoside transporter 4	0	0	0	1
Carbonic anhydrase 13	0	0	0	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 4	0	0	0	2
Carbonic anhydrase 13	0	1	0	4
Histamine H4 receptor	0	1	2	3
Carboxylic ester hydrolase	0	1	0	2
Carbonic anhydrase 14	0	0	0	3
Carbonic anhydrase 5B, mitochondrial	0	1	0	4
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Histidine-binding periplasmic protein	0	0	1	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
N-glycosylase/DNA lyase	0	1	0	1
Formamidopyrimidine-DNA glycosylase	0	1	0	1
Cytochrome P450 2C8	0	3	0	3
Endonuclease III-like protein 1	0	1	0	1
Pantothenate synthetase	0	1	0	1
Isocitrate lyase	0	1	0	1
Putative FAD-containing monooxygenase MymA	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Endonuclease 8-like 1	0	1	0	1
Chain A, beta-galactosidase	0	1	0	1
Chain A, Beta-galactosidase	0	1	0	1
Chain A, Beta-galactosidase	0	1	0	1
Chain A, Beta-galactosidase	0	1	0	1
Chain A, Beta-galactosidase	0	1	0	1
Chain A, Beta-galactosidase	0	1	0	1
Chain A, Beta-galactosidase	0	1	0	1
Chain A, Beta-galactosidase	0	1	0	1
Chain A, Beta-galactosidase	0	1	0	1
Chain A, Beta-galactosidase	0	1	0	1
Chain A, Beta-galactosidase	0	1	0	1
Chain A, Beta-galactosidase	0	1	0	1
Chain A, Beta-galactosidase	0	1	0	1
Chain A, Beta-galactosidase	0	1	0	1
Chain A, Beta-galactosidase	0	1	0	1
Beta-galactosidase	0	1	0	1
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
Gap junction alpha-1 protein	0	1	0	1
Gap junction beta-2 protein	0	1	0	1
Acyl-protein thioesterase 1	0	1	0	1
Potassium channel subfamily K member 3	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase IMP-1	0	0	0	2
Beta-lactamase	0	0	0	2
Solute carrier family 22 member 3	0	1	0	1
Amine oxidase [flavin-containing] B	0	3	0	3
Amine oxidase [flavin-containing] B	0	1	0	1
Synaptic vesicular amine transporter	0	2	0	2
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Acyl-CoA desaturase 1	0	1	0	1
Histidine decarboxylase	0	0	1	1
Proteinase-activated receptor 1	0	1	1	2
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Sialidase-4	0	1	0	1
Sialidase-1	0	1	0	1
Sialidase-3	0	1	0	1
Sialidase-2	0	1	0	1
Cholesteryl ester transfer protein	0	1	0	1
D-amino-acid oxidase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 3	0	0	1	1
Nicotinamidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	0	1	1
Hydroxycarboxylic acid receptor 2	0	2	1	3
D-aspartate oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	1	1	2
5-hydroxytryptamine receptor 3E	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit gamma	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Acetylcholine receptor subunit beta	0	2	1	3
Acetylcholine receptor subunit beta-like 2	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-5	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	2	4
5-hydroxytryptamine receptor 3A	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Acetylcholine-binding protein	0	1	1	2
Acetylcholine receptor subunit epsilon	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	1	1	2
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	1	2
Cytochrome P450 2A13	0	2	2	4
Neuronal acetylcholine receptor subunit alpha-5	0	2	0	2
Liver carboxylesterase B-1	0	1	0	1
5-hydroxytryptamine receptor 3D	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Soluble acetylcholine receptor	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-6	0	2	0	2
Integrin beta	0	0	1	1
Glycoprotein IIb	0	0	1	1
Sodium/iodide cotransporter	0	1	0	1
Estrogen receptor	0	0	1	1
Caspase-7	2	0	0	2
Estrogen receptor beta	0	0	1	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	2	0	2
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
Bifunctional cytochrome P450/NADPH--P450 reductase	0	0	1	1
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
Bombesin receptor subtype-3	0	0	1	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Fatty acid synthase	0	2	0	2
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 2	0	0	0	1
WD repeat-containing protein 5	0	1	0	1
Glutathione S-transferase omega-1	0	1	0	1
Histone-lysine N-methyltransferase 2A	0	1	0	1
Cytosolic endo-beta-N-acetylglucosaminidase	0	1	0	1
Chain A, Bacterial leucyl aminopeptidase	0	1	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	2	0	2
heat shock protein HSP 90-alpha isoform 2	0	2	0	2
26S proteasome non-ATPase regulatory subunit 14	0	1	0	1
Thermolysin	0	2	0	3
72 kDa type IV collagenase	0	2	0	2
Catechol O-methyltransferase	0	2	0	2
Catechol O-methyltransferase	0	1	0	1
Methionine aminopeptidase 1	0	1	0	1
Histone deacetylase 8	0	0	1	1
Valosin-containing protein	0	1	0	1
microphthalmia-associated transcription factor isoform 9	0	1	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Chain A, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Vascular endothelial growth factor receptor 1	0	1	0	1
Serine hydroxymethyltransferase, mitochondrial	0	1	0	1
Vascular endothelial growth factor receptor 3	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	2	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	2	0	2
CREB-binding protein	1	0	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	2	0	2
Phosphodiesterase	0	1	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	2
Amine oxidase [flavin-containing] A	0	2	0	2
Pyrroline-5-carboxylate reductase 1, mitochondrial	0	1	0	1
Renin	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase 1	0	0	0	1
Beta-lactamase OXA-10	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Chain C, Respiratory nitrate reductase 1 gamma chain	0	1	0	1
PINK1	1	0	0	1
Parkin	1	0	0	1
Pentachlorophenol 4-monooxygenase	0	0	1	1
ATP phosphoribosyltransferase	0	1	0	1
Rap guanine nucleotide exchange factor 4	2	0	0	2
ubiquitin-conjugating enzyme E2 N	0	1	0	1
protein AF-9 isoform a	0	0	0	1
bcl-2-related protein A1	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	2
Aldehyde oxidase 1	0	1	0	1
Retinal dehydrogenase 1	0	1	0	1
Aldehyde oxidase	0	2	0	2
Aldehyde oxidase 1	0	1	0	1
Aldehyde oxidase 1	0	1	0	1
Chain A, Immunoglobulin	0	0	1	1
Chain B, Immunoglobulin	0	0	1	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Cholinesterase	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Muscarinic acetylcholine receptor M5	0	0	1	2
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
SLC16A10 protein	0	0	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Monocarboxylate transporter 10	0	0	0	1
Phospholipase A-2-activating protein	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Acyl-CoA:cholesterol acyltransferase	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Muscarinic acetylcholine receptor DM1	0	1	0	1
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 60	0	0	1	1
Sodium/potassium/calcium exchanger 4	0	1	1	2
Taste receptor type 2 member 14	0	0	1	1
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Sodium/potassium/calcium exchanger 2	0	1	1	2
luciferase	0	0	0	1
Estrogen receptor	0	5	1	6
Progesterone receptor	0	5	1	7
Glucocorticoid receptor	0	2	1	3
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	5	2	8
Androgen receptor	0	4	1	5
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	4	1	5
Calmodulin-1	0	1	1	2
Calmodulin	0	0	2	2
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Chloroquine resistance transporter	0	2	0	2
Beta-1 adrenergic receptor	0	1	1	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Endothelin-1 receptor	0	1	1	2
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Vasopressin V1a receptor	0	1	1	2
Beta-2 adrenergic receptor	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
Interleukin-5	0	1	0	1
Interleukin-5	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Interleukin-5 receptor subunit alpha	0	1	0	1
N	0	1	0	1
Glutathione reductase, mitochondrial	0	1	0	1
Riboflavin-binding protein	0	1	1	2
Major prion protein	0	1	0	1
Histidine-rich protein PFHRP-II	0	1	0	1
DNA-directed RNA polymerase subunit alpha	0	1	0	1
DNA-directed RNA polymerase subunit omega	0	1	0	1
DNA-directed RNA polymerase subunit beta'	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Acidic phospholipase A2 2	0	1	0	1
Aldehyde oxidase 1	0	1	0	1
Cyclic GMP-AMP synthase	0	1	0	1
caspase-1 isoform alpha precursor	1	0	0	1
Quinolone resistance protein NorA	0	1	0	2
DNA topoisomerase 1	0	1	0	1
Chromaffin granule amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	2	1	3
Synaptic vesicular amine transporter	0	1	0	1
Neutral amino acid transporter A	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Free fatty acid receptor 3	0	0	1	1
Chain A, Mineralocorticoid receptor	0	1	0	1
Chain A, Mineralocorticoid receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	0	1
Gamma-aminobutyric acid receptor subunit rho-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit rho-2	0	0	0	1
Glycine receptor subunit beta	0	1	0	1
Taste receptor type 2 member 46	0	0	1	1
Taste receptor type 2 member 10	0	0	1	2
Prothrombin	0	1	0	1
Trypsin-1	0	1	0	1
Trypsin-2	0	1	0	1
Trypsin-3	0	1	0	1
Protein argonaute-2	0	0	1	1
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
ATP-dependent 6-phosphofructokinase	0	1	0	1
Dihydropteroate synthase	0	1	0	1
Dihydrofolate reductase	0	3	0	4
estrogen receptor beta isoform 1	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
Stromelysin-1	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Neutrophil collagenase	0	1	0	1
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
1-deoxy-D-xylulose-5-phosphate synthase	0	0	1	1
1-deoxy-D-xylulose-5-phosphate synthase	0	0	1	1
Alcohol dehydrogenase E chain	0	1	0	1
Alcohol dehydrogenase S chain	0	1	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Endolysin	0	0	1	1
Genome polyprotein	0	1	0	1
Ubiquitin carboxyl-terminal hydrolase 1	0	1	0	1
Lysozyme C-1	0	1	0	1
Glycoprotein hormones alpha chain	1	0	0	1
Protein kinase C alpha type	0	1	0	1
Beta-glucuronidase	0	1	0	1
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Protein kinase C eta type	0	1	0	1
Calcium-dependent protein kinase 4	0	1	0	1
WD repeat-containing protein 48	0	1	0	1
Emopamil-binding protein-like	0	1	0	1
Protein kinase C theta type	0	1	0	1
Chain A, Dihydrofolate Reductase	0	0	1	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, dihydrofolate reductase (DHFR)	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase type 1	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
NH(3)-dependent NAD(+) synthetase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase type 1 from Tn4003	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Trace amine-associated receptor 5	0	0	1	1
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase	0	1	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
Glycoprotein	0	1	0	1
Multidrug resistance-associated protein 1	0	2	1	4
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

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Overview

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Treatment

Research

Studies (391)

Protein Targets (1,453)

Botulism

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (391)

Drugs Studied (244)

Protein Targets (1,453)