An EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitor that inhibits the action of ribonucleoside-diphosphate reductase (EC 1.17.4.1).
ChEBI ID: 74213
| Member | Definition | Class |
|---|---|---|
| gemcitabine | A 2'-deoxycytidine having geminal fluoro substituents in the 2'-position. An inhibitor of ribonucleotide reductase, gemcitabine is used in the treatment of various carcinomas, particularly non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer. | gemcitabine |
| gemcitabine hydrochloride | A 2'-deoxycytidine hydrochloriode having geminal fluoro substituents in the 2'-position. An inhibitor of ribonucleotide reductase, gemcitabine hydrochloride is used in the treatment of various carcinomas, including non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer. | gemcitabine hydrochloride |
| guanazole | An aromatic amine that is 1,2,4-triazole substituted at positions 3 and 5 by amino groups. | guanazole |
| hydroxyurea | A member of the class of ureas that is urea in which one of the hydrogens is replaced by a hydroxy group. An antineoplastic used in the treatment of chronic myeloid leukaemia as well as for sickle-cell disease. | hydroxyurea |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 2,700 (13.14) | 18.7374 |
| 1990's | 2,165 (10.54) | 18.2507 |
| 2000's | 5,859 (28.52) | 29.6817 |
| 2010's | 7,545 (36.73) | 24.3611 |
| 2020's | 2,273 (11.07) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 3,952 (18.34%) | 5.53% |
| Reviews | 2,289 (10.62%) | 6.00% |
| Case Studies | 2,244 (10.42%) | 4.05% |
| Observational | 101 (0.47%) | 0.25% |
| Other | 12,959 (60.15%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| acetylcholinesterase | Homo sapiens (human) | Potency | 43.6486 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 13.2906 | 3 | 3 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 50.1187 | 2 | 2 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 0.1177 | 2 | 2 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 2 | 2 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 43.6486 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 4.3889 | 4 | 4 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 2.1132 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 12.7300 | 4 | 5 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 0.0224 | 1 | 1 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 14.1064 | 4 | 4 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 1.3332 | 1 | 1 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 14.7564 | 1 | 2 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 42.7076 | 2 | 3 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 28.1838 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 11.9048 | 2 | 2 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 3.1623 | 2 | 2 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 11.8880 | 3 | 5 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 47.7548 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 0.6682 | 1 | 1 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 8.9125 | 1 | 1 |
| polyprotein | Zika virus | Potency | 14.7564 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 43.1990 | 1 | 2 |
| progesterone receptor | Homo sapiens (human) | Potency | 19.6734 | 2 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 5.3325 | 2 | 3 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 15.8479 | 3 | 8 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 12.5243 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 0.4930 | 2 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 0.0094 | 2 | 2 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 16.3522 | 3 | 3 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 0.0457 | 2 | 2 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 8.9125 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 8.9125 | 1 | 1 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 31.4597 | 1 | 1 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Angiotensin-converting enzyme 2 | Homo sapiens (human) | EC50 | 3.0800 | 1 | 2 |
| Procathepsin L | Homo sapiens (human) | EC50 | 3.0800 | 1 | 2 |
| Replicase polyprotein 1a | Severe acute respiratory syndrome-related coronavirus | EC50 | 3.0800 | 1 | 2 |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | EC50 | 3.0800 | 1 | 2 |
| Replicase polyprotein 1ab | Human coronavirus 229E | EC50 | 3.0800 | 1 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | EC50 | 3.0800 | 1 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | EC50 | 3.0800 | 1 | 2 |
| Spike glycoprotein | Betacoronavirus England 1 | EC50 | 3.0800 | 1 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | EC50 | 3.0800 | 1 | 2 |
| Stromelysin-1 | Homo sapiens (human) | Kd | 25,000.0000 | 1 | 1 |
| Transmembrane protease serine 2 | Homo sapiens (human) | EC50 | 3.0800 | 1 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| AAA family ATPase | Staphylococcus aureus | Km | 192.0000 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Kinact | 28.0000 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Kinact | 23.0000 | 1 | 1 |
| Cytidine deaminase | Homo sapiens (human) | Km | 600.6667 | 3 | 3 |
| Deoxycytidine kinase | Homo sapiens (human) | Km | 1.7750 | 2 | 2 |