ascorbic-acid and Fever

Henoch-Schönlein purpura (HSP) is an extremely rare condition in patients with pulmonary tuberculosis, with only a few reported cases. Compared to patients with typical clinical symptoms, it is difficult to make a definitive diagnosis when HSP presents as an initial manifestation in pulmonary tuberculosis patients. Herein, a case of pulmonary tuberculosis that showed HSP at first was reported, and the related literatures were reviewed.. A 24-year-old man presented with palpable purpura on the extremities, accompanied by abdominal pain, bloody stools, and knee pain.. The patient was diagnosed with pulmonary tuberculosis based on the results of interferon gamma release assays, purified protein derivative test, and computed tomography.. The patient was treated with vitamin C and chlorpheniramine for 2 weeks, and the above-mentioned symptoms were relieved. However, 3 weeks later, the purpura recurred with high-grade fever and chest pain during the inspiratory phase. The patient was then treated with anti-tuberculosis drugs, and the purpura as well as the high fever disappeared.. The patient recovered well and remained free of symptoms during the follow-up examination.. Pulmonary tuberculosis presenting with HSP as an initial manifestation is not common. Therefore, it is difficult to clinically diagnose and treat this disease. When an adult patient shows HSP, it is important to consider the possibility of tuberculosis to avoid misdiagnosis and delayed treatment.

Topics: Abdominal Pain; Aftercare; Antitubercular Agents; Ascorbic Acid; Chlorpheniramine; Diagnosis, Differential; Fever; Gastrointestinal Hemorrhage; Histamine H1 Antagonists; Humans; IgA Vasculitis; Interferon-gamma Release Tests; Male; Treatment Outcome; Tuberculin; Tuberculosis, Pulmonary; Vitamins; Young Adult

Topics: Ascorbic Acid; Child, Preschool; Deficiency Diseases; Female; Fever; Folic Acid; Humans; Infant; Infant Food; Infant Nutritional Physiological Phenomena; Infant, Newborn; Infections; Kinetics; Male; Milk, Human; Nutritional Physiological Phenomena; Nutritional Requirements; Pyridoxine; Thiamine; Vitamin A; Vitamin A Deficiency; Vitamin D; Vitamin E; Vitamin K; Vitamins

There is limited evidence regarding early treatment of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection to mitigate symptom progression.. To examine whether high-dose zinc and/or high-dose ascorbic acid reduce the severity or duration of symptoms compared with usual care among ambulatory patients with SARS-CoV-2 infection.. This multicenter, single health system randomized clinical factorial open-label trial enrolled 214 adult patients with a diagnosis of SARS-CoV-2 infection confirmed with a polymerase chain reaction assay who received outpatient care in sites in Ohio and Florida. The trial was conducted from April 27, 2020, to October 14, 2020.. Patients were randomized in a 1:1:1:1 allocation ratio to receive either 10 days of zinc gluconate (50 mg), ascorbic acid (8000 mg), both agents, or standard of care.. The primary end point was the number of days required to reach a 50% reduction in symptoms, including severity of fever, cough, shortness of breath, and fatigue (rated on a 4-point scale for each symptom). Secondary end points included days required to reach a total symptom severity score of 0, cumulative severity score at day 5, hospitalizations, deaths, adjunctive prescribed medications, and adverse effects of the study supplements.. A total of 214 patients were randomized, with a mean (SD) age of 45.2 (14.6) years and 132 (61.7%) women. The study was stopped for a low conditional power for benefit with no significant difference among the 4 groups for the primary end point. Patients who received usual care without supplementation achieved a 50% reduction in symptoms at a mean (SD) of 6.7 (4.4) days compared with 5.5 (3.7) days for the ascorbic acid group, 5.9 (4.9) days for the zinc gluconate group, and 5.5 (3.4) days for the group receiving both (overall P = .45). There was no significant difference in secondary outcomes among the treatment groups.. In this randomized clinical trial of ambulatory patients diagnosed with SARS-CoV-2 infection, treatment with high-dose zinc gluconate, ascorbic acid, or a combination of the 2 supplements did not significantly decrease the duration of symptoms compared with standard of care.. ClinicalTrials.gov Identifier: NCT04342728.

Topics: Adult; Ambulatory Care; Antioxidants; Ascorbic Acid; Cough; COVID-19; COVID-19 Drug Treatment; Dietary Supplements; Dyspnea; Fatigue; Female; Fever; Gluconates; Humans; Male; Middle Aged; SARS-CoV-2; Severity of Illness Index; Standard of Care; Trace Elements; Treatment Outcome; Zinc

Several metabolic changes characteristic of the acute-phase response were examined in healthy men and women following a single 1 g dose of ascorbic acid. Utilizing a placebo-controlled, double-blind protocol, oral body temperatures were recorded in rested, fasted subjects (0900 hr) prior to the consumption of 1 g L-ascorbic acid or placebo (n = 10/group). Temperatures were recorded hourly for the next 8 hours, and again the next morning in the rested, fasted state (0900 hr). Blood samples, collected at 0, 4, and 24 hours post-dose, were analyzed for plasma ascorbate, iron, and zinc. Mean oral body temperature was significantly elevated 2 hours post-dose in the experimental subjects compared to controls (+0.7 degrees F, p = 0.03). In the vitamin-dosed subjects, mean plasma ascorbate rose 32% over the control value after 4 hours (1.11 +/- 0.08 and 0.84 +/- 0.06 mg/100 ml, ns). Serum iron levels were similar in the two groups at 0 and 4 hours post-dose, but at 24 hours post-dose mean serum iron of the vitamin-dosed subjects fell to 73% of that recorded for the control subjects (77 +/- 8 and 105 +/- 10 micrograms/100 ml, p = 0.04). Plasma zinc levels were similar for both groups at 0, 4, and 24 hours post-dose. These data indicate that ascorbate administration, at a level commonly supplemented in the US diet, elicits several host metabolic responses similar to those observed following exposure to infectious or inflammatory agents. These metabolic changes are most likely due to the reducing potential of the vitamin and may factor in the reported prophylactic success of vitamin C supplementation.

Topics: Acute-Phase Reaction; Adolescent; Adult; Ascorbic Acid; Body Temperature; Clinical Trials as Topic; Double-Blind Method; Female; Fever; Humans; Inflammation; Iron; Male; Trace Elements; Zinc

The results of a clinical trial of a new presentation designed for pediatric patients in 29 children are reported. Rectal temperature was recorded every 3 hours, for 12 hours. Patients were given a 12 mg/kg dose every 6 hours. A significant and satisfactory decrease in body temperature was observed. No undesirable side effects were recorded.

Topics: Acetaminophen; Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Ascorbic Acid; Bacterial Infections; Child, Preschool; Clinical Trials as Topic; Drug Combinations; Female; Fever; Humans; Male; Solutions; Virus Diseases

Hosts' innate defense systems are upregulated by antimicrobial peptide elicitors (APEs). Our aim was to investigate the effects of hyperthermia, ultraviolet A rays (UVA), and ultraviolet C rays (UVC) as well as glucose and ascorbic acid (AA) on the regulation of human β-defensin 1 (DEFB1), cathelicidin (CAMP), and interferon-γ (IFNG) genes in normal human keratinocytes (NHK). The indirect in vitro antimicrobial activity against Staphylococcus aureus and Listeria monocytogenes of these potential APEs was tested. We found that AA is a more potent APE for DEFB1 than glucose in NHK. Glucose but not AA is an APE for CAMP. Mild hypo- (35°C) and hyperthermia (39°C) are not APEs in NHK. AA-dependent DEFB1 upregulation below 20 mM predicts in vitro antimicrobial activity as well as glucose- and AA-dependent CAMP and IFNG upregulation. UVC upregulates CAMP and DEFB1 genes but UVA only upregulates the DEFB1 gene. UVC is a previously unrecognized APE in human cells. Our results suggest that glucose upregulates CAMP in an IFN-γ-independent manner. AA is an elicitor of innate immunity that will challenge the current concept of late activation of adaptive immunity of this vitamin. These results could be useful in designing new potential drugs and devices to combat skin infections.

Topics: Antimicrobial Cationic Peptides; Ascorbic Acid; beta-Defensins; Cathelicidins; Fever; Gene Expression Regulation; Glucose; Humans; Immunity, Innate; Interferon-gamma; Keratinocytes; Listeria monocytogenes; RNA, Messenger; Staphylococcus aureus; Ultraviolet Rays

Bacterial meningitis is a common cause of morbidity and mortality in children. The oxidative stress in bacterial meningitis is barely determined. Forty children with bacterial meningitis were studied for their oxidants and antioxidants status in serum and cerebrospinal fluid. Fever (95%) was commonest presentation followed by seizure and vomiting. Neck rigidity and Kernig's sign were present in 37.5% and 27.5% cases, respectively. Plasma and cerebrospinal fluid malondialdehyde, protein carbonyl and nitrite levels were significantly raised in cases (p < 0.001). Plasma and cerebrospinal fluid ascorbic acid, glutathione and superoxide dismutase levels were significantly decreased in children with septic meningitis (p < 0.001). Significantly elevated malondialdehyde, nitrite and protein carbonyl levels reflect increased oxidative stress, whereas decreased concentrations of glutathione, ascorbic acid and superoxide dismutase indicates utilization of the antioxidants in septic meningitis. Thus, changes in oxidants and antioxidants observed suggest production of reactive oxygen species and their possible role in pathogenesis of septic meningitis.

Topics: Antioxidants; Ascorbic Acid; Child; Child, Preschool; Cross-Sectional Studies; Female; Fever; Glutathione; Humans; Male; Malondialdehyde; Meningitis, Bacterial; Nitrites; Oxidants; Oxidative Stress; Prospective Studies; Reactive Oxygen Species; Superoxide Dismutase

Neutrophil function and the severity and incidence of mastitis in dairy cows is related to the intake of many antioxidant nutrients. Because vitamin C is the major water-soluble antioxidant in mammals, we examined the effect of dietary vitamin C on neutrophil function and responses to intramammary infusion of lipopolysaccahride (LPS) in periparturient dairy cows. At 2 wk before anticipated calving, Holstein cows were fed diets that provided 0 (16 cows) or 30 (15 cows) g/d of supplemental vitamin C (phosphorylated ascorbic acid). Treatments continued until 7 d after cows received an infusion of 10 microg of LPS into one quarter of the mammary gland (on average, this occurred 32 d postcalving). Supplementation of vitamin C increased plasma concentrations of vitamin C at calving, but no differences were observed in samples taken 24 h postinfusion. Concentrations of vitamin C in milk (24 h postinfusion) and in neutrophils (calving and 24 h postinfusion) were not affected by treatment, but vitamin C concentrations in neutrophils isolated from milk were about 3 times greater than concentrations in blood neutrophils. The LPS infusion did not alter concentrations of vitamin C in plasma or milk, suggesting that the LPS model did not produce the same effects as a bacterial infection of the mammary gland with respect to antioxidant effects. Supplemental vitamin C had no effect on neutrophil phagocytosis or bacterial kill. Dietary vitamin C reduced the milk somatic cell count but did not affect the febrile response or milk production following LPS infusion.

Topics: Animals; Antioxidants; Ascorbic Acid; Blood Bactericidal Activity; Cattle; Diet; Female; Fever; Kinetics; Lipopolysaccharides; Mammary Glands, Animal; Mastitis, Bovine; Milk; Neutrophils; Parturition; Phagocytosis; Pregnancy

Full expression of reflex cutaneous vasodilation (VD) is dependent on nitric oxide (NO) and is attenuated with essential hypertension. Decreased NO-dependent VD may be due to 1) increased oxidant stress and/or 2) decreased L-arginine availability through upregulated arginase activity, potentially leading to increased superoxide production through uncoupled NO synthase (NOS). The purpose of this study was to determine the effect of antioxidant supplementation (alone and combined with arginase inhibition) on attenuated NO-dependent reflex cutaneous VD in hypertensive subjects. Nine unmedicated hypertensive [HT; mean arterial pressure (MAP) = 112 +/- 1 mmHg] and nine age-matched normotensive (NT; MAP = 81 +/- 10 mmHg) men and women were instrumented with four intradermal microdialysis (MD) fibers: control (Ringer), NOS inhibited (NOS-I; 10 mM N(G)-nitro-L-arginine), L-ascorbate supplemented (Asc; 10 mM L-ascorbate), and Asc + arginase inhibited [Asc+A-I; 10 mM L-ascorbate + 5 mM (S)-(2-boronoethyl)-L-cysteine-HCl + 5 mM N(omega)-hydroxy-nor-L-arginine]. Oral temperature was increased by 0.8 degrees C via a water-perfused suit. N(G)-nitro-L-arginine was then ultimately perfused through all MD sites to quantify the change in VD due to NO. Red blood cell flux was measured by laser-Doppler flowmetry over each skin MD site, and cutaneous vascular conductance (CVC) was calculated (CVC = flux/MAP) and normalized to maximal CVC (%CVC(max); 28 mM sodium nitroprusside + local heating to 43 degrees C). During the plateau in skin blood flow (Delta T(or) = 0.8 degrees C), cutaneous VD was attenuated in HT skin (NT: 42 +/- 4, HT: 35 +/- 3 %CVC(max); P < 0.05). Asc and Asc+A-I augmented cutaneous VD in HT (Asc: 57 +/- 5, Asc+A-I: 53 +/- 6 %CVC(max); P < 0.05 vs. control) but not in NT. %CVC(max) after NOS-I in the Asc- and Asc+A-I-treated sites was increased in HT (Asc: 41 +/- 4, Asc+A-I: 40 +/- 4, control: 29 +/- 4; P < 0.05). Compared with the control site, the change in %CVC(max) within each site after NOS-I was greater in HT (Asc: -19 +/- 4, Asc+A-I: -17 +/- 4, control: -9 +/- 2; P < 0.05) than in NT. Antioxidant supplementation alone or combined with arginase inhibition augments attenuated reflex cutaneous VD in hypertensive skin through NO- and non-NO-dependent mechanisms.

Topics: Administration, Cutaneous; Antioxidants; Arginase; Ascorbic Acid; Blood Flow Velocity; Blood Vessels; Boronic Acids; Case-Control Studies; Enzyme Inhibitors; Female; Fever; Humans; Hypertension; Laser-Doppler Flowmetry; Male; Microdialysis; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Reflex; Skin; Time Factors; Vasodilation

Building on the work of the late John Myers, MD, the author has used an intravenous vitamin-and-mineral formula for the treatment of a wide range of clinical conditions. The modified "Myers' cocktail," which consists of magnesium, calcium, B vitamins, and vitamin C, has been found to be effective against acute asthma attacks, migraines, fatigue (including chronic fatigue syndrome), fibromyalgia, acute muscle spasm, upper respiratory tract infections, chronic sinusitis, seasonal allergic rhinitis, cardiovascular disease, and other disorders. This paper presents a rationale for the therapeutic use of intravenous nutrients, reviews the relevant published clinical research, describes the author's clinical experiences, and discusses potential side effects and precautions.

Topics: Administration, Oral; Adult; Aged; Ascorbic Acid; Asthma; Body Temperature; Calcium Gluconate; Child, Preschool; Depression; Drug Combinations; Fatigue; Female; Fever; Fibromyalgia; Heart Failure; Humans; Hydroxocobalamin; Infusions, Intravenous; Magnesium Chloride; Male; Middle Aged; Migraine Disorders; Pantothenic Acid; Pyridoxine; Respiratory Tract Infections; Vitamin B Complex

MDMA-induced 5-HT neurotoxicity has been proposed to involve oxidative stress due to increased formation of hydroxyl radicals. Recently, MDMA-induced 5-HT neurotoxicity has been shown to be accompanied by a suppression of behavioral and neurochemical responses to a subsequent injection of MDMA. The intent of the present study was to examine whether suppression of the MDMA-induced formation of hydroxyl radicals by an antioxidant, ascorbic acid, attenuates both the MDMA-induced depletion of 5-HT and the functional consequences associated with this depletion. Treatment of rats with ascorbic acid suppressed the generation of hydroxyl radicals, as evidenced by the production of 2,3-dihydroxybenzoic acid from salicylic acid, in the striatum during the administration of a neurotoxic regimen of MDMA. Ascorbic acid also attenuated the MDMA-induced depletion of striatal 5-HT content. In rats treated with a neurotoxic regimen of MDMA, the ability of a subsequent injection of MDMA to increase the extracellular concentration of 5-HT in the striatum, elicit the 5-HT behavioral syndrome, and produce hyperthermia was markedly reduced compared to the responses in control rats. The concomitant administration of ascorbic acid with the neurotoxic regimen of MDMA prevented the diminished neurochemical and behavioral responses to a subsequent injection of MDMA. Finally, a neurotoxic regimen of MDMA produced significant reductions in the concentrations of vitamin E and ascorbic acid in the striatum and hippocampus. Thus, the MDMA-induced depletion of brain 5-HT and the functional consequences thereof appear to involve the induction of oxidative stress resulting from an increased generation of free radicals and diminished antioxidant capacity of the brain.

Topics: Animals; Antioxidants; Ascorbic Acid; Behavior, Animal; Brain; Dopamine; Dose-Response Relationship, Drug; Fever; Hippocampus; Male; N-Methyl-3,4-methylenedioxyamphetamine; Neostriatum; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Agents

Serotonin type 2A (5-HT(2A)) receptor-mediated neurotransmitter is known to activate hypothalamic-pituitary-adrenal (HPA) axis, regulate sleep-awake cycle, induce anorexia and hyperthermia. Interaction between melatonin and 5-HT(2A) receptors in the regulation of the sleep-awake cycle and head-twitch response in rat have been reported. Previous studies have shown that melatonin has suppressant effect on HPA axis activation, decreases core body temperature and induces hyperphagia in animals. However, melatonin interaction with 5-HT(2A) receptors in mediation of these actions is not yet reported. We have studied the acute effect of melatonin and its antagonist, luzindole on centrally administered (+/-)-1-(2, 5-dimethoxy-4-iodophenyl) 2-amino propane (DOI; a 5-HT(2A/2C) agonist)-induced activation of HPA axis, hypophagia and hyperthermia in 24-h food-deprived rats. Like ritanserin [(1 mg/kg, i.p.) 5-HT(2A/2C) antagonist], peripherally administered melatonin (1.5 and 3 mg/kg, i.p.) did not affect the food intake, rectal temperature or basal adrenal ascorbic acid level. However, pretreatment of rats with it significantly reversed DOI (10 microgram, intraventricular)-induced anorexia and activation of HPA axis. But the hyperthermia induced by DOI was not sensitive to reversal by melatonin. Mel(1) receptor subtype antagonist luzindole (5 microgram, intraventricular) did not modulate the DOI effect but antagonized the melatonin (3 mg/kg, i.p.) reversal of 5-HT(2A) agonist response. The present data suggest that melatonin reversal of DOI-induced hypophagia could be due to suppression of 5-HT(2A) mediated activation of HPA axis.

Topics: Adrenal Glands; Amphetamines; Animals; Anorexia; Ascorbic Acid; Exploratory Behavior; Feeding Behavior; Fever; Gastrointestinal Transit; Hypothalamo-Hypophyseal System; Injections, Intraperitoneal; Injections, Intraventricular; Male; Melatonin; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Receptors, Serotonin; Ritanserin; Serotonin Antagonists; Suprachiasmatic Nucleus; Tryptamines

A series of experiments were conducted to examine the effect of single oral doses of ascorbic acid on body temperature in healthy guinea pigs. Fifteen male guinea pigs (approximately 200 g) were fed a nonpurified diet designed for rabbits (a scorbutogenic diet) ad libitum and received orally 2 mg L-ascorbic acid/100 g body wt daily. After acclimation, rectal temperatures were recorded hourly following five separate ascorbate dosage treatments: 0 (control dosage), 2, 10 or 50 mg ascorbic acid/100 g body wt, or 50 mg ascorbic acid and 0.07 mg indomethacin/100 g body wt. Mean body temperature was significantly elevated (P less than 0.05) after 1 h in animals receiving either the 10 or 50 mg dosage (+ 0.27 +/- 0.05 and + 0.41 +/- 0.07 degree C, respectively) compared to that in animals receiving the 2 mg dosage (-0.07 +/- 0.05 degree C), the recommended daily intake for guinea pigs. Changes in body temperature of animals receiving the 50 mg dosage plus indomethacin did not differ significantly from those reported with the 2 mg dosage. Thus, a single oral dose of ascorbic acid at levels 5-25 times the recommended intake, can elevate body temperature significantly in healthy guinea pigs, a phenomenon which is inhibited by indomethacin administration.

Topics: Animals; Ascorbic Acid; Body Temperature; Fever; Guinea Pigs; Indomethacin; Male; Prostaglandins

Groups of male Swiss-Webster mice were gavaged with acetaminophen (APAP), APAP + ascorbyl stearate (AS), or APAP + ascorbyl palmitate (AP) at a dose of 600 mg/kg for each chemical. APAP alone caused a significant increase in liver weight/body weight ratio and hepatic glutathione (GSH) depletion. Co-administration of the ascorbate esters AP or AS with APAP prevented an increase in liver weight/body weight ratios and hepatic glutathione depletion. APAP + AS treatments caused significantly greater reductions in rectal temperature at 15-30 min post-dosing periods when compared to APAP + AP or AS treatments. Blood levels of APAP had the same relationship. The study indicates a correlation between APAP blood levels and antipyretic effect of APAP + AS and APAP + AP coadministrations. While both ascorbate esters probably afford protection against APAP-induced hepatotoxicity in mice by reducing the reactive intermediate back to the parent compound, the APAP + AS combination provides better therapeutic efficacy as an antipyretic at the 15-30 min post-dosing periods.

Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ascorbic Acid; Body Weight; Drug Therapy, Combination; Fever; Glutathione; Liver; Male; Mice; Organ Size

Joshandah, polypharmaceutical herbal preparations, are used in the form of a sweetened decoction for the treatment of common cold, catarrh, cough and associated fevers in Unani (Greco-Arab) medicine. The rationale of their therapeutic efficacy is discussed in the light of reported chemico-pharmacological properties of the ingredients.

Topics: Ascorbic Acid; Common Cold; Cough; Fever; Humans; Phytotherapy; Plants, Medicinal

Three cases are described, 2 of Hodgkin's disease and a further case of bronchial carcinoma, where high dosage ascorbic acid treatment appeared to be associated with the development of potentially dangerous symptoms. It is suggested that mega ascorbic acid therapy should be given with caution in malignant disease, with a slow build-up over several days to high levels of dosage.

Topics: Adult; Aged; Animals; Antineoplastic Agents; Ascorbic Acid; Bronchial Neoplasms; Carcinoma, Small Cell; Dyspnea; Fever; Hodgkin Disease; Humans; Lung Neoplasms; Male; Neoplasms; Orthomolecular Therapy

Topics: Ascorbic Acid; Fever; Humans; Influenza A virus; Interferons; Lymphocyte Activation; Lymphocytes; Lymphokines; Macrophages; Mitogens; Phytohemagglutinins

Subcutaneous injection of chlorpromazine to rats caused a lesser increase in body temperature and a higher content of the corticotropin-releasing factor (CRF) in the hypothalamus and the ACTH in the hypophysis under conditions of exogenous hyperthermia. The ascorbic acid content in the adrenal glands decreased in the same way as in the animals overheated without any chlorpromazine. There was no significant change in the weight of the adrenal gland. A conclusion was drawn on the participation of the central adrenergic structure in the regulation of the synthesis or the secretion of the CRF.

Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Ascorbic Acid; Chlorpromazine; Corticotropin-Releasing Hormone; Fever; Hypothalamus; Organ Size; Pituitary Gland; Pituitary Gland, Anterior; Rats

Topics: Adolescent; Adult; Ascorbic Acid; Drug Combinations; Drug Evaluation; Female; Fever; Humans; Influenza, Human; Male; Middle Aged; Quinine; Salicylamides

Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Ascorbic Acid; Corticotropin-Releasing Hormone; Fever; Hypothalamo-Hypophyseal System; Hypothalamus; Pituitary Gland; Rats; Secretory Rate

Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Ascorbic Acid; Biological Assay; Corticotropin-Releasing Hormone; Fever; Heat Exhaustion; Hypothalamus; Pituitary Gland; Pituitary-Adrenal System; Rats; Time Factors

Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Ascorbic Acid; Electron Transport Complex IV; Fever; Oxidoreductases; Phosphoric Monoester Hydrolases; Rats; Succinate Dehydrogenase; Thyroid Gland

Topics: Anemia, Hypochromic; Ascorbic Acid; Bacterial Vaccines; Body Weight; Bone Marrow Examination; Deficiency Diseases; Female; Fever; Humans; Infant; Intestinal Absorption; Iron; Iron Isotopes; Jamaica; Kwashiorkor; Male; Pertussis Vaccine; Radiometry

Topics: Aminocaproates; Aminopyrine; Anaphylaxis; Animals; Aprotinin; Ascorbic Acid; Bordetella pertussis; Drug Synergism; Fever; Histamine H1 Antagonists; Hypothermia; Methysergide; Mice; Phenylbutazone; Temperature

Topics: Animals; Ascorbic Acid; Cattle; Cattle Diseases; Endotoxins; Eosinophils; Escherichia coli; Fever; Glucuronidase; Leukocyte Count; Lymphocytes; Neutrophils; Paratuberculosis; Phosphorus; Potassium

Topics: Ascorbic Acid; Drug Compounding; Drug Incompatibility; Female; Fever; Glucose; Humans; Hydrocortisone; Iatrogenic Disease

Topics: Adrenal Glands; Animals; Ascorbic Acid; Cornea; Fever; Ganglionic Blockers; Intestine, Large; Lung; Male; Peripheral Nerves; Rats; Skin; Tongue

Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Ascorbic Acid; Bronchitis; Child; Fever; Guaiacol; Humans; Infant; Measles; Suppositories

Topics: Acclimatization; Adaptation, Physiological; Adrenal Glands; Animals; Ascorbic Acid; Blood Chemical Analysis; Fever; Flavonoids; Guinea Pigs; Hot Temperature; Liver; Metabolism; Pharmacology; Rats; Research; Rutin; Temperature; Vitamins

Topics: Ascorbic Acid; Basal Metabolism; Environment; Female; Fever; Hot Temperature; Humans; Temperature

Topics: Ascorbic Acid; Fever; Humans; Temperature

Topics: Ascorbic Acid; Fever; Herpesviridae Infections; Humans; Hyperthermia, Induced; Therapeutics

Topics: Ascorbic Acid; Blood; Fever; Humans; Pneumonia