An agent that binds to and activates excitatory amino acid receptors.
| Member | Definition | Class |
|---|
| dysiherbaine | A furopyran that is (3aR,7aR)-hexahydro-2H-furo[3,2-b]pyran substituted by carboxy, (2S)-2-amino-2-carboxyethyl, hydroxy and methylamino groups at positions 2, 2, 6, and 7, respectively (the 2R,3aR,6S,7R,7aR-stereoisomer). A convulsant isolated from the marine sponge Dysidea herbacea that has high affinity for kainate ionotropic glutamate receptors. | dysiherbaine |
| kainic acid | | kainic acid |
| neodysiherbaine a | A furopyran that is (3aR,7aR)-hexahydro-2H-furo[3,2-b]pyran substituted by carboxy, (2S)-2-amino-2-carboxyethyl, hydroxy and hydroxy groups at positions 2, 2, 6, and 7, respectively (the 2R,3aR,6R,7R,7aR-stereoisomer). A convulsant isolated from the marine sponge Dysidea herbacea. | neodysiherbaine A |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | IC50 | 16.2500 | 7 | 8 |
| Glutamate receptor 1 | Homo sapiens (human) | Ki | 7.4663 | 3 | 3 |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | Ki | 0.4770 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | IC50 | 16.2500 | 7 | 8 |
| Glutamate receptor 2 | Homo sapiens (human) | Ki | 12.2070 | 3 | 3 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Ki | 4.9950 | 2 | 2 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | IC50 | 16.2500 | 7 | 8 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | Ki | 1.9800 | 1 | 1 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | IC50 | 16.2500 | 7 | 8 |
| Glutamate receptor 4 | Homo sapiens (human) | Ki | 1.7113 | 3 | 3 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | Ki | 3.5700 | 1 | 1 |
| Glutamate receptor ionotropic, kainate 1 | Homo sapiens (human) | IC50 | 0.0770 | 1 | 1 |
| Glutamate receptor ionotropic, kainate 1 | Rattus norvegicus (Norway rat) | IC50 | 0.0126 | 8 | 10 |
| Glutamate receptor ionotropic, kainate 1 | Homo sapiens (human) | Ki | 0.1182 | 3 | 3 |
| Glutamate receptor ionotropic, kainate 1 | Rattus norvegicus (Norway rat) | Ki | 0.0742 | 2 | 3 |
| Glutamate receptor ionotropic, kainate 2 | Homo sapiens (human) | IC50 | 0.0770 | 1 | 1 |
| Glutamate receptor ionotropic, kainate 2 | Rattus norvegicus (Norway rat) | IC50 | 0.0126 | 8 | 10 |
| Glutamate receptor ionotropic, kainate 2 | Homo sapiens (human) | Ki | 0.0296 | 4 | 4 |
| Glutamate receptor ionotropic, kainate 2 | Rattus norvegicus (Norway rat) | Ki | 0.0103 | 3 | 4 |
| Glutamate receptor ionotropic, kainate 3 | Homo sapiens (human) | IC50 | 0.0770 | 1 | 1 |
| Glutamate receptor ionotropic, kainate 3 | Rattus norvegicus (Norway rat) | IC50 | 0.0126 | 8 | 10 |
| Glutamate receptor ionotropic, kainate 3 | Homo sapiens (human) | Ki | 0.0100 | 2 | 2 |
| Glutamate receptor ionotropic, kainate 3 | Rattus norvegicus (Norway rat) | Ki | 0.0183 | 1 | 2 |
| Glutamate receptor ionotropic, kainate 4 | Homo sapiens (human) | IC50 | 0.0770 | 1 | 1 |
| Glutamate receptor ionotropic, kainate 4 | Rattus norvegicus (Norway rat) | IC50 | 0.0126 | 8 | 10 |
| Glutamate receptor ionotropic, kainate 4 | Rattus norvegicus (Norway rat) | Ki | 0.0047 | 1 | 1 |
| Glutamate receptor ionotropic, kainate 5 | Homo sapiens (human) | IC50 | 0.0770 | 1 | 1 |
| Glutamate receptor ionotropic, kainate 5 | Rattus norvegicus (Norway rat) | IC50 | 0.0126 | 8 | 10 |
| Glutamate receptor ionotropic, kainate 5 | Homo sapiens (human) | Ki | 0.0883 | 3 | 3 |
| Glutamate receptor ionotropic, kainate 5 | Rattus norvegicus (Norway rat) | Ki | 0.0150 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 6 | 7 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | Ki | 68.7667 | 3 | 3 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 5 | 6 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | Ki | 68.7667 | 3 | 3 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 5 | 6 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | Ki | 68.7667 | 3 | 3 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 5 | 6 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | Ki | 68.7667 | 3 | 3 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 5 | 6 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | Ki | 68.7667 | 3 | 3 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 5 | 6 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | Ki | 68.7667 | 3 | 3 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 5 | 6 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | Ki | 68.7667 | 3 | 3 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| Chain A, Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Kd | 0.1600 | 1 | 2 |
| Chain C, Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Kd | 0.1600 | 1 | 1 |
| Glutamate receptor 1 | Homo sapiens (human) | EC50 | 49.5025 | 4 | 4 |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | EC50 | 24.3333 | 3 | 3 |
| Glutamate receptor 2 | Homo sapiens (human) | EC50 | 34.0350 | 2 | 2 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | EC50 | 380.0000 | 2 | 2 |
| Glutamate receptor 3 | Homo sapiens (human) | EC50 | 26.6100 | 1 | 1 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | EC50 | 37.0000 | 3 | 3 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | EC50 | 47.0000 | 2 | 2 |
| Glutamate receptor ionotropic, kainate 1 | Homo sapiens (human) | EC50 | 16.2000 | 2 | 2 |
| Glutamate receptor ionotropic, kainate 1 | Rattus norvegicus (Norway rat) | EC50 | 37.0000 | 1 | 1 |
| Glutamate receptor ionotropic, kainate 2 | Homo sapiens (human) | EC50 | 0.7000 | 2 | 2 |
| Glutamate receptor ionotropic, kainate 2 | Rattus norvegicus (Norway rat) | EC50 | 1.8000 | 1 | 1 |
| Glutamate receptor ionotropic, kainate 2 | Rattus norvegicus (Norway rat) | Kd | 0.0390 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | EC50 | 25.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | EC50 | 25.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | EC50 | 25.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | EC50 | 25.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | EC50 | 25.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | EC50 | 25.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | EC50 | 25.0000 | 1 | 1 |
| Metabotropic glutamate receptor 5 | Homo sapiens (human) | EC50 | 33.6000 | 1 | 1 |
| Metabotropic glutamate receptor 6 | Homo sapiens (human) | EC50 | 299.0000 | 1 | 1 |