Page last updated: 2024-08-05 15:32:20
excitatory amino acid agonist
An agent that binds to and activates excitatory amino acid receptors.
ChEBI ID: 50103
Members (3)
| Member | Definition | Class |
|---|---|---|
| dysiherbaine | A furopyran that is (3aR,7aR)-hexahydro-2H-furo[3,2-b]pyran substituted by carboxy, (2S)-2-amino-2-carboxyethyl, hydroxy and methylamino groups at positions 2, 2, 6, and 7, respectively (the 2R,3aR,6S,7R,7aR-stereoisomer). A convulsant isolated from the marine sponge Dysidea herbacea that has high affinity for kainate ionotropic glutamate receptors. | dysiherbaine |
| kainic acid | kainic acid | |
| neodysiherbaine a | A furopyran that is (3aR,7aR)-hexahydro-2H-furo[3,2-b]pyran substituted by carboxy, (2S)-2-amino-2-carboxyethyl, hydroxy and hydroxy groups at positions 2, 2, 6, and 7, respectively (the 2R,3aR,6R,7R,7aR-stereoisomer). A convulsant isolated from the marine sponge Dysidea herbacea. | neodysiherbaine A |
Research
Studies (9,293)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 1,831 (19.70) | 18.7374 |
| 1990's | 3,105 (33.41) | 18.2507 |
| 2000's | 2,363 (25.43) | 29.6817 |
| 2010's | 1,617 (17.40) | 24.3611 |
| 2020's | 377 (4.06) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 3 (0.03%) | 5.53% |
| Reviews | 214 (2.23%) | 6.00% |
| Case Studies | 7 (0.07%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 9,353 (97.66%) | 84.16% |
Protein Targets (55)
Potency Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 17.3768 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 33.8078 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 0.1259 | 2 | 2 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 29.8493 | 2 | 2 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 12.5893 | 1 | 1 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| endonuclease IV | Escherichia coli | Potency | 15.8489 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 29.8493 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 0.7308 | 1 | 2 |
| GLS protein | Homo sapiens (human) | Potency | 5.6234 | 1 | 1 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| IDH1 | Homo sapiens (human) | Potency | 29.0929 | 1 | 1 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 2.8214 | 1 | 2 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 35.4813 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 26.2000 | 1 | 2 |
| snurportin-1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 14.3176 | 2 | 2 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 0.3548 | 1 | 1 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 13.3332 | 1 | 1 |
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | IC50 | 16.2500 | 7 | 8 |
| Glutamate receptor 1 | Homo sapiens (human) | Ki | 7.4663 | 3 | 3 |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | Ki | 0.4770 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | IC50 | 16.2500 | 7 | 8 |
| Glutamate receptor 2 | Homo sapiens (human) | Ki | 12.2070 | 3 | 3 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Ki | 4.9950 | 2 | 2 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | IC50 | 16.2500 | 7 | 8 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | Ki | 1.9800 | 1 | 1 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | IC50 | 16.2500 | 7 | 8 |
| Glutamate receptor 4 | Homo sapiens (human) | Ki | 1.7113 | 3 | 3 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | Ki | 3.5700 | 1 | 1 |
| Glutamate receptor ionotropic, kainate 1 | Homo sapiens (human) | IC50 | 0.0770 | 1 | 1 |
| Glutamate receptor ionotropic, kainate 1 | Rattus norvegicus (Norway rat) | IC50 | 0.0126 | 8 | 10 |
| Glutamate receptor ionotropic, kainate 1 | Homo sapiens (human) | Ki | 0.1182 | 3 | 3 |
| Glutamate receptor ionotropic, kainate 1 | Rattus norvegicus (Norway rat) | Ki | 0.0742 | 2 | 3 |
| Glutamate receptor ionotropic, kainate 2 | Homo sapiens (human) | IC50 | 0.0770 | 1 | 1 |
| Glutamate receptor ionotropic, kainate 2 | Rattus norvegicus (Norway rat) | IC50 | 0.0126 | 8 | 10 |
| Glutamate receptor ionotropic, kainate 2 | Homo sapiens (human) | Ki | 0.0296 | 4 | 4 |
| Glutamate receptor ionotropic, kainate 2 | Rattus norvegicus (Norway rat) | Ki | 0.0103 | 3 | 4 |
| Glutamate receptor ionotropic, kainate 3 | Homo sapiens (human) | IC50 | 0.0770 | 1 | 1 |
| Glutamate receptor ionotropic, kainate 3 | Rattus norvegicus (Norway rat) | IC50 | 0.0126 | 8 | 10 |
| Glutamate receptor ionotropic, kainate 3 | Homo sapiens (human) | Ki | 0.0100 | 2 | 2 |
| Glutamate receptor ionotropic, kainate 3 | Rattus norvegicus (Norway rat) | Ki | 0.0183 | 1 | 2 |
| Glutamate receptor ionotropic, kainate 4 | Homo sapiens (human) | IC50 | 0.0770 | 1 | 1 |
| Glutamate receptor ionotropic, kainate 4 | Rattus norvegicus (Norway rat) | IC50 | 0.0126 | 8 | 10 |
| Glutamate receptor ionotropic, kainate 4 | Rattus norvegicus (Norway rat) | Ki | 0.0047 | 1 | 1 |
| Glutamate receptor ionotropic, kainate 5 | Homo sapiens (human) | IC50 | 0.0770 | 1 | 1 |
| Glutamate receptor ionotropic, kainate 5 | Rattus norvegicus (Norway rat) | IC50 | 0.0126 | 8 | 10 |
| Glutamate receptor ionotropic, kainate 5 | Homo sapiens (human) | Ki | 0.0883 | 3 | 3 |
| Glutamate receptor ionotropic, kainate 5 | Rattus norvegicus (Norway rat) | Ki | 0.0150 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 6 | 7 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | Ki | 68.7667 | 3 | 3 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 5 | 6 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | Ki | 68.7667 | 3 | 3 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 5 | 6 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | Ki | 68.7667 | 3 | 3 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 5 | 6 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | Ki | 68.7667 | 3 | 3 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 5 | 6 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | Ki | 68.7667 | 3 | 3 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 5 | 6 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | Ki | 68.7667 | 3 | 3 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 5 | 6 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | Ki | 68.7667 | 3 | 3 |
Activation Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Chain A, Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Kd | 0.1600 | 1 | 2 |
| Chain C, Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Kd | 0.1600 | 1 | 1 |
| Glutamate receptor 1 | Homo sapiens (human) | EC50 | 49.5025 | 4 | 4 |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | EC50 | 24.3333 | 3 | 3 |
| Glutamate receptor 2 | Homo sapiens (human) | EC50 | 34.0350 | 2 | 2 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | EC50 | 380.0000 | 2 | 2 |
| Glutamate receptor 3 | Homo sapiens (human) | EC50 | 26.6100 | 1 | 1 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | EC50 | 37.0000 | 3 | 3 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | EC50 | 47.0000 | 2 | 2 |
| Glutamate receptor ionotropic, kainate 1 | Homo sapiens (human) | EC50 | 16.2000 | 2 | 2 |
| Glutamate receptor ionotropic, kainate 1 | Rattus norvegicus (Norway rat) | EC50 | 37.0000 | 1 | 1 |
| Glutamate receptor ionotropic, kainate 2 | Homo sapiens (human) | EC50 | 0.7000 | 2 | 2 |
| Glutamate receptor ionotropic, kainate 2 | Rattus norvegicus (Norway rat) | EC50 | 1.8000 | 1 | 1 |
| Glutamate receptor ionotropic, kainate 2 | Rattus norvegicus (Norway rat) | Kd | 0.0390 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | EC50 | 25.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | EC50 | 25.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | EC50 | 25.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | EC50 | 25.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | EC50 | 25.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | EC50 | 25.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | EC50 | 25.0000 | 1 | 1 |
| Metabotropic glutamate receptor 5 | Homo sapiens (human) | EC50 | 33.6000 | 1 | 1 |
| Metabotropic glutamate receptor 6 | Homo sapiens (human) | EC50 | 299.0000 | 1 | 1 |