Page last updated: 2024-08-05 15:00:17

synthetic auxin

A synthetic compound exhibiting auxin activity.

ChEBI ID: 26841

Members (10)

MemberDefinitionClass
1-naphthaleneacetic acidA naphthylacetic acid substituted by a carboxymethyl group at position 1.1-naphthaleneacetic acid
2-methyl-4-chlorophenoxyacetic acidA chlorophenoxyacetic acid that is (4-chlorophenoxy)acetic acid substituted by a methyl group at position 2.(4-chloro-2-methylphenoxy)acetic acid
2,4-dichlorophenoxyacetic acidA chlorophenoxyacetic acid that is phenoxyacetic acid in which the ring hydrogens at postions 2 and 4 are substituted by chlorines.2,4-D
2,4,5-trichlorophenoxyacetic acidA chlorophenoxyacetic acid that is phenoxyacetic acid in which the ring hydrogens at postions 2, 4 and 5 are substituted by chlorines.(2,4,5-trichlorophenoxy)acetic acid
4-(2,4-dichlorophenoxy)butyric acidA monocarboxylic acid that is butyric acid in which one of the hydrogens at position 4 is replaced by a 2,4-dichlorophenoxy group. A selective post-emergence herbicide.2,4-DB
aminocyclopyrachlorAn organochlorine herbicide, the structure of which is that of pyrimidine-4-carboxylic acid substituted at positions 2, 5 and 6 by cyclopropyl, chloro and amino groups respectively.aminocyclopyrachlor
dicambaA methoxybenzoic acid that is O-methylsalicylic acid substituted by chloro groups at positions 3 and 6.dicamba
naphthaleneacetamideA member of the class of naphthalenes that is naphthalene which is substituted by a 2-amino-2-oxoethyl group at position 1. It is a synthetic auxin that is widely used in agriculture to promote the growth of numerous fruits, for root cuttings and as a fruit thinning agent.1-naphthaleneacetamide
picloramA pyridinemonocarboxylic acid that is pyridine-2-carboxylic acid which is substituted by a chloro group at positions 3,5 and 6, and by an amino group at position 4. It is a systemic herbicide used to control deeply rooted herbaceous weeds and woody plants in rights-of-way, forestry, range lands, pastures, and small grain crops.picloram
quincloracA quinolinemonocarboxylic acid that is quinoline-8-carboxylic acid in which the hydrogens at positions 3 and 7 have been replaced by chlorines. It is used (particularly as its dimethylamine salt, known as quinclorac-dimethylammonium) as a (rather persistent) herbicide for the post-emergence control of weeds in rice, grass and turf. It is not approved for use within the European Union.quinclorac

Research

Studies (4,023)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19901,042 (25.90)18.7374
1990's542 (13.47)18.2507
2000's1,017 (25.28)29.6817
2010's1,023 (25.43)24.3611
2020's399 (9.92)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials9 (0.17%)5.53%
Reviews173 (3.28%)6.00%
Case Studies101 (1.91%)4.05%
Observational0 (0.00%)0.25%
Other4,998 (94.64%)84.16%

Protein Targets (71)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
67.9K proteinVaccinia virusPotency3.162311
acetylcholinesteraseHomo sapiens (human)Potency81.072211
activating transcription factor 6Homo sapiens (human)Potency24.703113
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency39.810711
AR proteinHomo sapiens (human)Potency28.3922821
aryl hydrocarbon receptorHomo sapiens (human)Potency50.859727
ATAD5 protein, partialHomo sapiens (human)Potency1.157711
Ataxin-2Homo sapiens (human)Potency61.130611
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency61.130611
Cellular tumor antigen p53Homo sapiens (human)Potency32.696013
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency19.952611
Chain A, Beta-lactamaseEscherichia coli K-12Potency35.481311
Chain A, HADH2 proteinHomo sapiens (human)Potency31.622811
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency0.177811
Chain A, Putative fructose-1,6-bisphosphate aldolaseGiardia intestinalisPotency17.740711
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency19.405513
Chain B, HADH2 proteinHomo sapiens (human)Potency31.622811
chromobox protein homolog 1Homo sapiens (human)Potency50.118711
cytochrome P450 2C9, partialHomo sapiens (human)Potency57.394711
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency31.275812
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency49.398411
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency94.562612
estrogen nuclear receptor alphaHomo sapiens (human)Potency21.3002834
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency38.148624
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency33.389139
farnesoid X nuclear receptorHomo sapiens (human)Potency24.958323
GVesicular stomatitis virusPotency57.394711
gemininHomo sapiens (human)Potency0.063424
GLI family zinc finger 3Homo sapiens (human)Potency57.791313
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency23.078913
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency23.474013
Guanine nucleotide-binding protein GHomo sapiens (human)Potency22.387211
heat shock protein beta-1Homo sapiens (human)Potency62.762711
Histone H2A.xCricetulus griseus (Chinese hamster)Potency126.793011
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency57.394711
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency26.700612
IDH1Homo sapiens (human)Potency0.580511
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency57.394712
Inositol monophosphatase 1Rattus norvegicus (Norway rat)Potency0.079411
Interferon betaHomo sapiens (human)Potency57.394711
LuciferasePhotinus pyralis (common eastern firefly)Potency59.654836
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency54.6527311
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency4.814212
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency61.043139
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency36.4606410
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency27.2553412
phosphopantetheinyl transferaseBacillus subtilisPotency7.079511
pregnane X nuclear receptorHomo sapiens (human)Potency56.376426
progesterone receptorHomo sapiens (human)Potency13.800525
RAR-related orphan receptor gammaMus musculus (house mouse)Potency17.713725
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency36.904035
retinoid X nuclear receptor alphaHomo sapiens (human)Potency26.6554315
serine/threonine-protein kinase PLK1Homo sapiens (human)Potency29.934911
SMAD family member 2Homo sapiens (human)Potency22.6832212
SMAD family member 3Homo sapiens (human)Potency22.6832212
TAR DNA-binding protein 43Homo sapiens (human)Potency5.552812
TDP1 proteinHomo sapiens (human)Potency43.277111
thioredoxin reductaseRattus norvegicus (Norway rat)Potency45.123612
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency39.325239
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency11.180714
thyroid stimulating hormone receptorHomo sapiens (human)Potency60.492612
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency55.937311
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency23.1893411
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency23.474013

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)IC5032.000022
Androgen receptorRattus norvegicus (Norway rat)IC50457.088011
Prostaglandin D2 receptorHomo sapiens (human)Ki10.000011
Prostaglandin D2 receptor 2Homo sapiens (human)Ki10.000011
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrialPisum sativum (garden pea)IC504,530.000022
Pyruvate dehydrogenase E1 component subunit beta, mitochondrialPisum sativum (garden pea)IC504,530.000022

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Chain C, auxin-binding protein 1Zea maysKd0.150011