Page last updated: 2024-08-05 15:13:32
antiparasitic agent
A substance used to treat or prevent parasitic infections.
ChEBI ID: 35442
Members (19)
| Member | Definition | Class |
|---|---|---|
| 4-methyl-1-(1-methylethyl)-3-cyclohexen-1-ol | A terpineol that is 1-menthene carrying a hydroxy substituent at position 4. | 4-terpineol |
| anisomycin | An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system. | (-)-anisomycin |
| annomontine | An alkaloid that is beta-carboline substituted at position C-1 by a 2-aminopyrimidin-4-yl moiety. An antiparasitic agent found in Annona montana and Annona foteida. | annomontine |
| aureothin | A C-nitro compound that is (3Z)-3-[(2E)-2-methyl-3-(4-nitrophenyl)prop-2-en-1-ylidene]tetrahydrofuran which is substituted by a 6-methoxy-3,5-dimethyl-4-oxo-4H-pyran-2-yl group at position 5. It is isolated from the soil bacterium, Streptomyces thioluteus and exhibits antitumor, antifungal, and insecticidal activities. | aureothin |
| benzoylmetronidazole | A benzoate ester resulting from the formal condensation of benzoic acid with the hydroxy group of metronidazole. | metronidazole benzoate |
| costunolide | A germacranolide with anthelminthic, antiparasitic and antiviral activities. | costunolide |
| cycloguanil | A triazine in which a 1,6-dihydro-1,3,5-triazine ring is substituted at N-1 by a 4-chlorophenyl group, at C-2 and -4 by amino groups and at C-6 by gem-dimethyl groups. A dihydrofolate reductase inhibitor, it is a metabolite of the antimalarial drug proguanil. | cycloguanil |
| diaveridine | An aminopyrimidine in which the pyrimidine ring carries amino substituents at C-2 and C-4 and a 3,4-dimethoxybenzyl group at C-5. A folic acid antagonist, it is used as a synergist with sulfonamides against the parasitic Eimeria species. | diaveridine |
| dimetridazole | A C-nitro compound that is 5-nitroimidazole in which the hydrogens at positions 1 and 2 are replaced by methyl groups. An antiprotozoal drug, it has been banned by both the Government of Canada and the European Union as a livestock feed additive owing to suspicions of it being carcinogenic. | dimetridazole |
| diminazene | A triazene derivative that is triazene in which each of the terminal nitrogens is substituted by a 4-carbamimidoylphenyl group. | diminazene |
| diminazene aceturate | An N-acetylglycinate salt resulting from the reaction of diminazene with 2 mol eq. of N-acetylglycine. | diminazene diaceturate |
| e 64 | E64 zwitterion; E64 | |
| erysodine | An erythrina alkaloid with formula C18H21NO3 isolated from several erythrina plant species. It is a competitive antagonist of nicotinic acetylcholine receptors and exhibits antiparasitic and insecticidal activities. | erysodine |
| leflunomide | A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide. | leflunomide |
| metronidazole | A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death. | metronidazole |
| niclosamide | A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections. | niclosamide |
| paromomycin | An amino cyclitol glycoside that is the 1-O-(2-amino-2-deoxy-alpha-D-glucopyranoside) and the 3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranoside of 4,6-diamino-2,3-dihydroxycyclohexane (the 1R,2R,3S,4R,6S diastereoisomer). It is obtained from various Streptomyces species. A broad-spectrum antibiotic, it is used (generally as the sulfate salt) for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoal infections. It is also used as a therapeutic against visceral leishmaniasis. | paromomycin |
| ronidazole | A carbamate ester that is 5-nitroimidazole in which the hydrogens at positions 1 and 2 are replaced by methyl and (carbamoyloxy)methyl groups, respectively. An antiprotozoal agent, it is used in veterinary medicine for the treatment of histomoniasis and swine dysentery. | ronidazole |
| tinidazole | 1H-imidazole substituted at C-1 by a (2-ethylsulfonyl)ethyl group, at C-2 by a methyl group and at C-5 by a nitro group. It is used as an antiprotozoal, antibacterial agent. | tinidazole |
Research
Studies (20,242)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 5,459 (26.97) | 18.7374 |
| 1990's | 3,597 (17.77) | 18.2507 |
| 2000's | 4,615 (22.80) | 29.6817 |
| 2010's | 4,930 (24.36) | 24.3611 |
| 2020's | 1,641 (8.11) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 3,168 (13.70%) | 5.53% |
| Reviews | 1,904 (8.24%) | 6.00% |
| Case Studies | 2,782 (12.03%) | 4.05% |
| Observational | 73 (0.32%) | 0.25% |
| Other | 15,191 (65.71%) | 84.16% |
Protein Targets (317)
Potency Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 67.9K protein | Vaccinia virus | Potency | 1.1322 | 2 | 4 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 48.5088 | 1 | 2 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 31.5153 | 2 | 4 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 19.8715 | 1 | 4 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 8.1062 | 1 | 4 |
| AR protein | Homo sapiens (human) | Potency | 8.1114 | 10 | 27 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 3.6282 | 3 | 9 |
| arylsulfatase A | Homo sapiens (human) | Potency | 37.9330 | 1 | 2 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 3.8429 | 10 | 14 |
| Ataxin-2 | Homo sapiens (human) | Potency | 4.6875 | 1 | 4 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 4.4257 | 2 | 6 |
| atrial natriuretic peptide receptor 1 precursor | Homo sapiens (human) | Potency | 0.9528 | 1 | 1 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 1.3092 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 24.0682 | 2 | 4 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 1.8058 | 1 | 2 |
| caspase-3 | Homo sapiens (human) | Potency | 1.8058 | 1 | 2 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 9.3422 | 3 | 8 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 5.0816 | 2 | 9 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 5.6234 | 1 | 1 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 5.6234 | 1 | 1 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 28.1838 | 1 | 1 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 70.7946 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 0.0398 | 1 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 0.0398 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 100.0000 | 1 | 2 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 8.1235 | 1 | 2 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 11.5886 | 1 | 3 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 9.2876 | 1 | 2 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 18.9979 | 1 | 2 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 5.4332 | 2 | 10 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 4.1198 | 1 | 2 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 1.8602 | 1 | 4 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 0.3445 | 2 | 2 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 2.0749 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 54.7876 | 1 | 3 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 29.9349 | 1 | 1 |
| endonuclease IV | Escherichia coli | Potency | 11.2202 | 1 | 1 |
| Endothelin receptor type B | Rattus norvegicus (Norway rat) | Potency | 17.7828 | 1 | 1 |
| Endothelin-1 receptor | Rattus norvegicus (Norway rat) | Potency | 17.7828 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 7.2492 | 9 | 31 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 17.3427 | 2 | 4 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 1.7135 | 10 | 34 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 5.5528 | 1 | 2 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 11.1715 | 4 | 9 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 11.3132 | 4 | 6 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 4.2284 | 1 | 1 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 6.0880 | 1 | 3 |
| G | Vesicular stomatitis virus | Potency | 9.2876 | 1 | 2 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 5.4332 | 1 | 5 |
| GALC protein | Homo sapiens (human) | Potency | 0.5120 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 5.4332 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 5.4332 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 5.4332 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 5.4332 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 5.4332 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 5.4332 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 5.4332 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 5.4332 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 5.4332 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 5.4332 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 5.4332 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 5.4332 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 5.4332 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 5.4332 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 5.4332 | 1 | 5 |
| geminin | Homo sapiens (human) | Potency | 3.1755 | 4 | 13 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 11.3761 | 3 | 10 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 7.8552 | 1 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 2.1784 | 2 | 4 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 4.5374 | 1 | 4 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 1.9953 | 1 | 1 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 1.8493 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 17.5038 | 2 | 5 |
| hepatitis C virus polyprotein | Potency | 7.0456 | 1 | 1 | |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 9.5104 | 2 | 11 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 1.2460 | 2 | 8 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 130.6660 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 9.2876 | 1 | 2 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 9.5892 | 3 | 4 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 61.6448 | 1 | 2 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 2.2536 | 2 | 4 |
| IDH1 | Homo sapiens (human) | Potency | 4.9978 | 1 | 3 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 9.2876 | 1 | 4 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 5.0630 | 1 | 4 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 5.0630 | 1 | 4 |
| Interferon beta | Homo sapiens (human) | Potency | 15.8755 | 3 | 6 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 2.9476 | 2 | 10 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 0.3762 | 1 | 2 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 11.1662 | 4 | 9 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 5.1209 | 1 | 2 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 8.4209 | 2 | 3 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 10.2782 | 2 | 4 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 37.4528 | 1 | 5 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 0.0794 | 1 | 1 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 14.6945 | 1 | 3 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 0.6257 | 1 | 4 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 14.8617 | 3 | 7 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 3.1611 | 2 | 3 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 54.9410 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 11.4964 | 2 | 7 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 7.6006 | 1 | 2 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 1.4177 | 3 | 11 |
| Ornithine decarboxylase | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| P53 | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 0.7667 | 1 | 1 |
| Parkin | Homo sapiens (human) | Potency | 1.6337 | 2 | 3 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 11.5080 | 2 | 5 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 19.1562 | 1 | 2 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 1.1884 | 2 | 3 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 9.9929 | 4 | 7 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 39.8107 | 1 | 1 |
| PINK1 | Homo sapiens (human) | Potency | 1.6326 | 1 | 2 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 6.2303 | 1 | 2 |
| polyprotein | Zika virus | Potency | 6.0880 | 1 | 3 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 0.1585 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| PPM1D protein | Homo sapiens (human) | Potency | 18.5569 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 14.3442 | 2 | 6 |
| progesterone receptor | Homo sapiens (human) | Potency | 30.8960 | 1 | 3 |
| pyruvate kinase | Leishmania mexicana mexicana | Potency | 10.1474 | 4 | 4 |
| pyruvate kinase PKM isoform b | Homo sapiens (human) | Potency | 3.1623 | 2 | 2 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 7.3708 | 2 | 9 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 0.5807 | 1 | 4 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 16.8336 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 10.8516 | 3 | 16 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 17.1689 | 4 | 8 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 1.6208 | 2 | 2 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 1.4972 | 2 | 4 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 1.4972 | 2 | 4 |
| Smad3 | Homo sapiens (human) | Potency | 0.1365 | 4 | 4 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 1.6743 | 2 | 3 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 9.2837 | 2 | 12 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 21.0316 | 1 | 4 |
| TDP1 protein | Homo sapiens (human) | Potency | 7.6941 | 2 | 18 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 13.4823 | 1 | 3 |
| Thrombopoietin | Homo sapiens (human) | Potency | 4.0216 | 2 | 4 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 2.3747 | 2 | 8 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 17.7201 | 2 | 3 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 5.7834 | 2 | 6 |
| TSHR protein | Homo sapiens (human) | Potency | 92.5374 | 2 | 3 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 6.2303 | 1 | 2 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 6.2303 | 1 | 2 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 42.5559 | 1 | 3 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 57.1756 | 2 | 3 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 11.2460 | 4 | 9 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 63.0957 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 4.5374 | 1 | 4 |
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 3-phosphoinositide-dependent protein kinase 1 | Homo sapiens (human) | IC50 | 83.9000 | 1 | 1 |
| 30S ribosomal protein S1 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 30S ribosomal protein S10 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 30S ribosomal protein S11 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 30S ribosomal protein S12 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 30S ribosomal protein S13 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 30S ribosomal protein S14 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 30S ribosomal protein S15 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 30S ribosomal protein S16 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 30S ribosomal protein S17 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 30S ribosomal protein S18 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 30S ribosomal protein S19 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 30S ribosomal protein S2 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 30S ribosomal protein S20 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 30S ribosomal protein S21 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 30S ribosomal protein S3 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 30S ribosomal protein S4 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 30S ribosomal protein S5 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 30S ribosomal protein S6 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 30S ribosomal protein S7 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 30S ribosomal protein S8 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 30S ribosomal protein S9 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L1 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L10 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L11 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L13 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L14 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L15 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L16 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L17 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L18 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L19 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L2 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L20 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L21 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L22 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L23 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L24 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L25 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L27 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L28 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L29 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L3 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L30 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L31 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L31 type B | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L32 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L33 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L34 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L35 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L36 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L36 2 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L4 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L5 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L6 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L7/L12 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| Acid-sensing ion channel 1 | Mus musculus (house mouse) | IC50 | 51.0500 | 2 | 2 |
| Acid-sensing ion channel 2 | Mus musculus (house mouse) | IC50 | 107.1000 | 2 | 2 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 4.6300 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 4.5910 | 1 | 1 |
| Amiloride-sensitive amine oxidase [copper-containing] | Homo sapiens (human) | Ki | 0.0130 | 1 | 1 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 | 20.6960 | 1 | 1 |
| Angiopoietin-1 receptor | Homo sapiens (human) | IC50 | 67.8000 | 1 | 1 |
| Angiotensin-converting enzyme 2 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Anoctamin-1 | Homo sapiens (human) | IC50 | 0.0280 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 3 |
| Aurora kinase A | Homo sapiens (human) | IC50 | 54.1000 | 1 | 1 |
| Beta lactamase (plasmid) | Pseudomonas aeruginosa | IC50 | 49.7510 | 1 | 1 |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Plasmodium berghei ANKA | IC50 | 0.2100 | 1 | 1 |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Plasmodium falciparum K1 | IC50 | 24.9733 | 6 | 6 |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Plasmodium falciparum K1 | Ki | 1.0887 | 21 | 23 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 281.0667 | 3 | 6 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 111.6000 | 1 | 1 |
| Calpain-1 catalytic subunit | Homo sapiens (human) | IC50 | 0.1000 | 1 | 1 |
| Calpain-1 catalytic subunit | Sus scrofa (pig) | Ki | 3.9600 | 1 | 1 |
| Calpain-9 | Homo sapiens (human) | IC50 | 11.5800 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 3 |
| caspase recruitment domain family, member 15 | Homo sapiens (human) | IC50 | 49.7510 | 1 | 1 |
| Cathepsin B | Homo sapiens (human) | IC50 | 6.0141 | 5 | 5 |
| Cathepsin B | Homo sapiens (human) | Ki | 16.0000 | 1 | 1 |
| Cathepsin S | Homo sapiens (human) | IC50 | 0.0070 | 1 | 1 |
| cGMP-dependent 3',5'-cyclic phosphodiesterase | Homo sapiens (human) | IC50 | 5.8000 | 1 | 1 |
| Cruzipain | Trypanosoma cruzi | IC50 | 0.2100 | 2 | 2 |
| Cysteine protease | Trypanosoma brucei rhodesiense | IC50 | 0.0031 | 1 | 1 |
| Cysteine protease | Trypanosoma brucei rhodesiense | Ki | 0.0350 | 1 | 1 |
| Cysteine protease falcipain-3 | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 0.1972 | 3 | 3 |
| Cysteine proteinase falcipain 2a | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 0.0828 | 6 | 6 |
| Cysteine proteinase falcipain 2a | Plasmodium falciparum (malaria parasite P. falciparum) | Ki | 13.6267 | 3 | 3 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 0.5000 | 1 | 1 |
| Diamine acetyltransferase 1 | Homo sapiens (human) | Ki | 2.4000 | 1 | 1 |
| Dihydrofolate reductase | Escherichia coli K-12 | IC50 | 5.2805 | 4 | 4 |
| Dihydrofolate reductase | Gallus gallus (chicken) | IC50 | 300.0000 | 1 | 1 |
| Dihydrofolate reductase | Homo sapiens (human) | IC50 | 0.5300 | 1 | 1 |
| Dihydrofolate reductase | Neisseria gonorrhoeae | IC50 | 0.5300 | 2 | 2 |
| Dihydrofolate reductase | Pneumocystis carinii | IC50 | 0.4500 | 1 | 1 |
| Dihydrofolate reductase | Rattus norvegicus (Norway rat) | IC50 | 58.5275 | 4 | 4 |
| Dihydrofolate reductase | Escherichia coli K-12 | Ki | 0.5195 | 2 | 2 |
| Dihydrofolate reductase | Gallus gallus (chicken) | Ki | 17.3930 | 2 | 2 |
| Dihydrofolate reductase | Homo sapiens (human) | Ki | 14.4885 | 3 | 3 |
| Dihydrofolate reductase | Lacticaseibacillus casei | Ki | 8.7491 | 2 | 2 |
| Dihydrofolate reductase | Pneumocystis carinii | Ki | 36.3776 | 3 | 3 |
| Dihydrofolate reductase | Salmonella enterica subsp. enterica serovar Typhi | Ki | 0.0190 | 1 | 1 |
| Dihydroorotate dehydrogenase (quinone), mitochondrial | Homo sapiens (human) | IC50 | 7.9333 | 3 | 3 |
| Dihydroorotate dehydrogenase (quinone), mitochondrial | Mus musculus (house mouse) | IC50 | 0.0300 | 1 | 1 |
| Dihydroorotate dehydrogenase (quinone), mitochondrial | Rattus norvegicus (Norway rat) | IC50 | 0.0090 | 1 | 1 |
| Dipeptidyl peptidase 1 | Homo sapiens (human) | IC50 | 0.7700 | 1 | 1 |
| Epidermal growth factor receptor | Homo sapiens (human) | IC50 | 10.5000 | 1 | 1 |
| Fatty acid synthase | Rattus norvegicus (Norway rat) | IC50 | 300.0000 | 1 | 1 |
| Fibroblast growth factor receptor 1 | Homo sapiens (human) | IC50 | 13.1000 | 1 | 1 |
| Furin | Homo sapiens (human) | Ki | 5.4200 | 1 | 1 |
| Glucose transporter | Leishmania mexicana | IC50 | 0.2250 | 1 | 1 |
| glucose-6-phosphate 1-dehydrogenase isoform b | Homo sapiens (human) | IC50 | 80.0000 | 1 | 1 |
| glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | Plasmodium berghei | IC50 | 57.9000 | 3 | 3 |
| Glycogen synthase kinase-3 beta | Homo sapiens (human) | IC50 | 77.5000 | 1 | 1 |
| Hexose transporter 1 | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 0.3260 | 1 | 1 |
| Lanosterol 14-alpha demethylase | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| Liver carboxylesterase | Sus scrofa (pig) | IC50 | 300.0000 | 1 | 1 |
| Lysosomal protective protein | Homo sapiens (human) | IC50 | 300.0000 | 1 | 1 |
| Mast/stem cell growth factor receptor Kit | Homo sapiens (human) | IC50 | 27.8000 | 1 | 1 |
| Mitogen-activated protein kinase 1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Mitogen-activated protein kinase 8 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 3 |
| Neuronal acetylcholine receptor subunit alpha-4 | Homo sapiens (human) | Ki | 0.0500 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-7 | Homo sapiens (human) | Ki | 7.5000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-2 | Homo sapiens (human) | Ki | 0.0500 | 1 | 1 |
| Neutrophil elastase | Homo sapiens (human) | IC50 | 300.0000 | 1 | 1 |
| Papain | Carica papaya (papaya) | IC50 | 0.0187 | 3 | 3 |
| Papain | Carica papaya (papaya) | Ki | 5.0800 | 1 | 1 |
| Platelet-derived growth factor receptor beta | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Pro-cathepsin H | Homo sapiens (human) | IC50 | 0.1900 | 1 | 1 |
| Procathepsin L | Homo sapiens (human) | IC50 | 8.3565 | 6 | 6 |
| Procathepsin L | Homo sapiens (human) | Ki | 0.0300 | 1 | 1 |
| Protein kinase C alpha type | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Protein-arginine deiminase type-4 | Homo sapiens (human) | IC50 | 2,400.0000 | 1 | 1 |
| Proto-oncogene tyrosine-protein kinase Src | Homo sapiens (human) | IC50 | 10.2500 | 2 | 2 |
| RAC-alpha serine/threonine-protein kinase | Homo sapiens (human) | IC50 | 59.4000 | 1 | 1 |
| receptor-interacting serine/threonine-protein kinase 2 isoform 1 | Homo sapiens (human) | IC50 | 49.7510 | 1 | 1 |
| Receptor-type tyrosine-protein kinase FLT3 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Replicase polyprotein 1a | Severe acute respiratory syndrome-related coronavirus | IC50 | 50.0000 | 2 | 2 |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | IC50 | 50.0000 | 1 | 1 |
| Replicase polyprotein 1ab | Human coronavirus 229E | IC50 | 50.0000 | 2 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 30.0933 | 3 | 3 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | IC50 | 46.0000 | 5 | 5 |
| Serine/threonine-protein kinase B-raf | Homo sapiens (human) | IC50 | 100.0000 | 2 | 2 |
| Signal transducer and activator of transcription 3 | Homo sapiens (human) | IC50 | 0.2300 | 2 | 2 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 2.8840 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 2.2910 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 4.6300 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 4.5910 | 1 | 1 |
| Solute carrier family 2, facilitated glucose transporter member 1 | Homo sapiens (human) | IC50 | 0.3210 | 1 | 1 |
| Spike glycoprotein | Betacoronavirus England 1 | IC50 | 50.0000 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | IC50 | 50.0000 | 1 | 1 |
| Thioredoxin reductase | Entamoeba histolytica | Ki | 3.3000 | 1 | 1 |
| Transcriptional activator Myb | Gallus gallus (chicken) | IC50 | 30.6751 | 1 | 2 |
| Transmembrane protease serine 2 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Tyrosine-protein kinase ABL1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Tyrosine-protein kinase JAK2 | Homo sapiens (human) | IC50 | 55.0000 | 2 | 2 |
| Tyrosine-protein kinase Lyn | Homo sapiens (human) | IC50 | 23.8000 | 1 | 1 |
| Tyrosyl-DNA phosphodiesterase 1 | Homo sapiens (human) | IC50 | 21,000.0000 | 1 | 1 |
| UDP-N-acetylglucosamine 1-carboxyvinyltransferase | Escherichia coli K-12 | IC50 | 50.0000 | 1 | 2 |
| UDP-N-acetylglucosamine 1-carboxyvinyltransferase | Pseudomonas aeruginosa PAO1 | IC50 | 50.0000 | 1 | 2 |
| Vascular endothelial growth factor receptor 2 | Homo sapiens (human) | IC50 | 23.1000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Homo sapiens (human) | IC50 | 177.9000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1D | Homo sapiens (human) | IC50 | 177.9000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1F | Homo sapiens (human) | IC50 | 177.9000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1S | Homo sapiens (human) | IC50 | 177.9000 | 1 | 1 |
Activation Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Angiotensin-converting enzyme 2 | Homo sapiens (human) | EC50 | 0.0965 | 1 | 2 |
| bcl-2-like protein 11 isoform 1 | Homo sapiens (human) | EC50 | 350.0000 | 1 | 1 |
| Chain A, BCL-2-RELATED PROTEIN A1 | Homo sapiens (human) | EC50 | 350.0000 | 1 | 1 |
| Dihydrofolate reductase | Escherichia coli K-12 | Kd | 11.7700 | 1 | 1 |
| heat shock protein 90 | Candida albicans | EC50 | 1.4810 | 1 | 1 |
| Hsf1 protein | Mus musculus (house mouse) | EC50 | 0.2430 | 1 | 1 |
| matrix metalloproteinase 1, partial | Homo sapiens (human) | EC50 | 5.6500 | 1 | 1 |
| Procathepsin L | Homo sapiens (human) | EC50 | 0.0965 | 1 | 2 |
| Replicase polyprotein 1a | Severe acute respiratory syndrome-related coronavirus | EC50 | 0.0965 | 1 | 2 |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | EC50 | 0.0965 | 1 | 2 |
| Replicase polyprotein 1ab | Human coronavirus 229E | EC50 | 0.0965 | 1 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | EC50 | 0.0965 | 1 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | EC50 | 0.0965 | 1 | 2 |
| Spike glycoprotein | Betacoronavirus England 1 | EC50 | 0.0965 | 1 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | EC50 | 0.0965 | 1 | 2 |
| Taste receptor type 2 member 46 | Homo sapiens (human) | EC50 | 8.6000 | 1 | 1 |
| Trace amine-associated receptor 5 | Mus musculus (house mouse) | EC50 | 10.0000 | 1 | 1 |
| Transmembrane protease serine 2 | Homo sapiens (human) | EC50 | 0.0965 | 1 | 2 |
Other Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Bcl-2-like protein 11 | Homo sapiens (human) | AC50 | 99.9300 | 1 | 1 |
| Chain A, BCL-2-RELATED PROTEIN A1 | Homo sapiens (human) | AC50 | 150.3397 | 3 | 3 |
| Flavodoxin | Helicobacter pylori 26695 | MIC | 67.3000 | 3 | 3 |
| Hsf1 protein | Mus musculus (house mouse) | AC50 | 0.3610 | 3 | 3 |
| interferon gamma precursor | Homo sapiens (human) | AC50 | 24.5300 | 2 | 2 |
| PAX8 | Homo sapiens (human) | AC50 | 0.2600 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | IC60 | 6.9000 | 1 | 1 |
| Transcription factor p65 | Homo sapiens (human) | IC100 | 50.0000 | 1 | 1 |