Schwartzman Phenomenon

Hemorrhagic necrosis that was first demonstrated in rabbits with a two-step reaction, an initial local (intradermal) or general (intravenous) injection of a priming endotoxin (ENDOTOXINS) followed by a second intravenous endotoxin injection (provoking agent) 24 h later. The acute inflammation damages the small blood vessels. The following intravascular coagulation leads to capillary and venous THROMBOSIS and NECROSIS. Shwartzman phenomenon can also occur in other species with a single injection of a provoking agent, and during infections or pregnancy. Its susceptibility depends on the status of IMMUNE SYSTEM, coagulation, FIBRINOLYSIS, and blood flow.

Synonym
Schwartzman Phenomenon
Schwartzman Reaction
Shwartzman Phenomenon
Shwartzman Reaction

Excerpt	Reference
"Local Shwartzman reaction is substantially reduced in intensity by zinc administered locally before and after preparation of the reaction."	( Csernyánszky, H; Módis, L; Nagy, Z; Szilágyi, T, 1984)
"The Shwartzman reaction is an animal model displaying histopathological vasculitis phenomena."	( Geist, C; Schneider, J; Wöhrmann, T; Zwingenberger, K, 1995)

Excerpt	Reference
"The classic generalized Shwartzman reaction induced in the rabbit was prevented with large doses of aspirin (250 mg/kg) when administered at the time of the first and preparing injection of endotoxin."	( Bernard, F; Latour, JG, 1978)
"The generalized Shwartzman reaction (GSR) was produced by a single injection of endotoxin in male rats pretreated with catechol-o-methyltransferase (COMT) inhibitors (tropolone, pyrogallol)."	( Láger-Gauthier, C; Latour, JG, 1978)
"The conventional local Shwartzman reaction (LSR) did not occur in rabbits whose plasma haptoglobin (Hp) was lowered by treatment with carbon tetrachloride, nor in animals in whom Hp was elevated after treatment with turpentine, or PGE2 or endotoxin."	( Kim, IK; Shim, BS, 1978)
"Local Shwartzman reaction is substantially reduced in intensity by zinc administered locally before and after preparation of the reaction."	( Csernyánszky, H; Módis, L; Nagy, Z; Szilágyi, T, 1984)
"Both localized and generalized Shwartzman reactions were induced in the same rabbits by simultaneous administration of preparatory intravenous and intradermal doses of endotoxin followed in 24 hr by the provocative dose."	( Fong, JS; Good, RA, 1971)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	406 (92.69)	23.3326
1990's	22 (5.02)	12.5806
2000's	9 (2.05)	18.1394
2010's	1 (0.23)	28.8240
2020's	0 (0.00)	9.53

Drug	Relationship Strength	Studies
acetone	low	1
benzene	low	1
carbamates	low	1
chlorine	low	1
coumarin	low	4
aminocaproic acid	low	6
lactic acid	low	1
dimethyl sulfoxide	low	1
formaldehyde	low	2
glycine	low	1
glycerol	low	2
hydrogen carbonate	low	1
histamine	low	7
iodine	low	1
2-keto-3-deoxyoctonate	low	1
niacin	low	3
phenol	low	2
pyridoxine	low	1
pyrogallol	low	1
sulfuric acid	low	2
uric acid	low	1
1-anilino-8-naphthalenesulfonate	low	2
aspirin	low	4
azathioprine	low	1
busulfan	low	4
chlorambucil	low	1
chlorpromazine	low	1
dimercaprol	low	2
diphenhydramine	low	2
dipyridamole	low	2
erythrosine	low	1
fentanyl	low	1
gentamicin	low	1
phenelzine	low	1
indomethacin	low	6
isoniazid	low	1
2-propanol	low	1
isoproterenol	low	3
mecamylamine	low	1
mechlorethamine	low	17
metronidazole	low	1
nafamostat	low	1
neostigmine	low	1
aminosalicylic acid	low	1
pargyline	low	1
phenacetin	low	1
phenoxybenzamine	low	8
phenylbutazone	low	2
procaine	low	1
promethazine	low	1
propranolol	low	1
pyridinolcarbamate	low	1
stearic acid	low	1
sulfinpyrazone	low	1
sulfisoxazole	low	1
sulfobromophthalein	low	1
thalidomide	low	3
tranexamic acid	low	1
prednisolone	low	11
thymidine	low	2
hydroxyproline	low	1
thyroxine	low	1
dibenzylchlorethamine	low	2
prednisolone acetate	low	1
prednisone	low	3
estrone	low	1
carbon tetrachloride	low	1
serine	low	1
chloramphenicol	low	3
cyanides	low	2
aminopyrine	low	2
adenosine diphosphate	low	1
galactose	low	6
edetic acid	low	1
tyrosine	low	1
methylene blue	low	1
methacholine chloride	low	1
aniline	low	1
desoxycorticosterone	low	4
colchicine	low	7
cycloheximide	low	1
chloroform	low	1
norethynodrel	low	2
ampicillin	low	1
mestranol	low	2
methandrostenolone	low	1
tryptophan	low	1
arginine	low	1
trichloroacetic acid	low	2
phencyclidine	low	2
methylprednisolone	low	3
xanthenes	low	1
phenothiazine	low	2
bromobenzene	low	1
framycetin	low	1
indazoles	low	2
thiazoles	low	1
nitroblue tetrazolium	low	1
hematoxylin	low	1
tropolone	low	1
sodium hydroxide	low	2
thorium dioxide	low	19
d-alpha tocopherol	low	5
fucose	low	2
mannose	low	3
mercury	low	1
neodymium	low	3
ruthenium	low	1
scandium	low	2
thorium	low	3
chromium	low	1
gold	low	1
galactosamine	low	6
galactose	low	3
trolamine salicylate	low	3
rhamnose	low	3
hypnorm	low	1
phenyl acetate	low	2
triamcinolone	low	3
4-methoxyamphetamine	low	1
glucose, (beta-d)-isomer	low	4
thiazolyl blue	low	1
6-sulfanilamidoindazole	low	3
nicotine	low	1
fibrinogen	low	80
glycidyl nitrate	low	2
foxes	low	3
1-hexadecyl-2-acetyl-glycero-3-phosphocholine	low	2
sri 63-675	low	1
lipid x	low	1
gla 27	low	1
angiotensin ii	low	1
cortisone	low	18
dihydropyridines	low	1
fibrin	low	80
bradykinin	low	5
glucosamine	low	7
n-formylmethionine leucyl-phenylalanine	low	1
retinol	low	3
diethylstilbestrol	low	1
dactinomycin	low	4
glycosides	low	1
mercaptopurine	low	1
methylthiouracil	low	1
thiouracil	low	1
thiourea	low	1
krn 7000	low	3
quinine	low	1
modipafant	low	1
ovalbumin	low	2
sodium dodecyl sulfate	low	1
alpha-chymotrypsin	low	1
dinoprostone	low	4
vitamin k semiquinone radical	low	1
lead	low	1
arsenic	low	2
sulfur	low	2
cysteine	low	4
phosphorus	low	6
boron	low	1
triolein	low	1
asialo gm1 ganglioside	low	1
mocetinostat	low	1
lipid a	low	21
g(m1) ganglioside	low	1
acid phosphatase	low	4
fibrinopeptide b	low	1
tannins	low	1
fibrinopeptide a	low	1
peptones	low	1
glycolipids	low	4
interleukin-8	low	1
colistin	low	2
chondroitin	low	3
ascorbic acid	low	2
tetracycline	low	1
oxytetracycline, anhydrous	low	1
dicumarol	low	3
warfarin	low	11
phenprocoumon	low	1
4-hydroxycoumarin	low	1
ethyl biscoumacetate	low	1
kaolinite	low	1
agar	low	2
hirudin	low	3
caseins	low	1
hyaluronoglucosaminidase	low	2
thromboplastin	low	23
muramidase	low	2
trypan blue	low	3
eye	low	3
concanavalin a	low	3

Protein Targets (1,372)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain B, pheromone binding protein	0	0	1	1
Chain A, pheromone binding protein	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	9	0	0	9
Chain A, RNA-directed RNA polymerase NS5	0	2	0	2
acid sphingomyelinase	3	0	0	3
thioredoxin reductase	25	0	0	25
USP1 protein, partial	27	0	0	27
TDP1 protein	48	0	0	48
vitamin D3 receptor isoform VDRA	24	0	0	24
importin subunit beta-1 isoform 1	5	0	0	5
flap endonuclease 1	9	0	0	9
serine/threonine-protein kinase PLK1	6	0	0	6
snurportin-1	5	0	0	5
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	7	0	0	7
GTP-binding nuclear protein Ran isoform 1	3	0	0	3
DNA polymerase eta isoform 1	6	0	0	6
DNA polymerase iota isoform a (long)	19	0	0	19
urokinase-type plasminogen activator precursor	8	0	0	8
plasminogen precursor	8	0	0	8
urokinase plasminogen activator surface receptor precursor	8	0	0	8
geminin	44	0	0	44
DNA polymerase kappa isoform 1	16	0	0	16
fibroblast growth factor 22 isoform 1 precursor	0	0	0	2
Mitogen-activated protein kinase 13	0	1	0	1
Beta-lactamase	0	1	0	1
Transthyretin	0	1	1	3
Fatty acid-binding protein, intestinal	0	1	1	2
Fatty acid-binding protein, adipocyte	0	1	2	3
Cyclin-A2	0	2	0	2
Cannabinoid receptor 1	0	1	1	2
Cyclin-dependent kinase 2	0	2	1	3
Choline O-acetyltransferase	0	1	0	1
Mitogen-activated protein kinase 12	0	1	0	1
Guanine nucleotide-binding protein G	4	0	0	4
Fatty acid-binding protein 5	0	0	1	1
Fatty acid-binding protein 5	0	0	1	1
Mitogen-activated protein kinase 11	0	1	0	1
Mitogen-activated protein kinase 14	0	2	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	27	0	0	27
Chain A, Cruzipain	7	0	0	7
regulator of G-protein signaling 4	18	0	0	18
Platelet-activating factor receptor	0	2	0	2
Inositol monophosphatase 1	9	0	0	9
hypoxia-inducible factor 1 alpha subunit	19	0	0	19
RAR-related orphan receptor gamma	45	0	0	45
GLI family zinc finger 3	51	0	0	51
AR protein	61	0	0	61
aldehyde dehydrogenase 1 family, member A1	35	0	0	35
retinoic acid nuclear receptor alpha variant 1	51	0	0	51
retinoid X nuclear receptor alpha	37	0	0	37
estrogen nuclear receptor alpha	68	0	0	68
peroxisome proliferator-activated receptor delta	33	0	0	33
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	29	0	0	29
activating transcription factor 6	22	0	0	22
v-jun sarcoma virus 17 oncogene homolog (avian)	34	0	0	34
Histone H2A.x	23	0	0	23
thyroid hormone receptor beta isoform a	22	0	0	22
heat shock protein beta-1	16	0	0	16
nuclear factor erythroid 2-related factor 2 isoform 1	48	0	0	48
lamin isoform A-delta10	42	0	0	42
Voltage-dependent calcium channel gamma-2 subunit	20	0	0	20
Glutamate receptor 2	20	0	0	20
Carbonic anhydrase 12	0	4	0	9
Carbonic anhydrase 1	0	16	0	21
Carbonic anhydrase 2	0	16	0	22
Aldo-keto reductase family 1 member B1	0	3	0	3
Xanthine dehydrogenase/oxidase	0	2	0	2
Sorbitol dehydrogenase	0	2	0	2
Carbonic anhydrase 9	0	5	0	10
Integrase	0	4	0	4
5-hydroxytryptamine receptor 2C	0	3	1	4
5-hydroxytryptamine receptor 2A	0	4	1	5
5-hydroxytryptamine receptor 1A	0	8	2	11
5-hydroxytryptamine receptor 1B	0	7	1	8
5-hydroxytryptamine receptor 1D	0	1	1	2
5-hydroxytryptamine receptor 1F	0	1	1	2
5-hydroxytryptamine receptor 2B	0	3	1	4
5-hydroxytryptamine receptor 6	0	0	1	1
Sodium-dependent serotonin transporter	0	12	1	13
Sodium-dependent serotonin transporter	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	1	2
5-hydroxytryptamine receptor 5A	0	0	1	1
5-hydroxytryptamine receptor 5B	0	0	1	1
5-hydroxytryptamine receptor 3A	0	0	1	1
5-hydroxytryptamine receptor 4	0	0	1	1
5-hydroxytryptamine receptor 3B	0	0	1	1
glucocorticoid receptor [Homo sapiens]	48	0	0	48
estrogen-related nuclear receptor alpha	54	0	0	54
thyroid hormone receptor beta isoform 2	43	0	0	43
Chain A, Heat Shock Protein 90	0	0	1	1
Chain A, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain B, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, Myosin Ie Heavy Chain	0	0	1	1
Chain A, Preprotein translocase secA	0	0	1	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Phosphoribosylformylglycinamidine synthase	0	1	0	1
Chain A, nucleoside diphosphate kinase A	0	0	1	1
Chain B, nucleoside diphosphate kinase A	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A, Kinesin-like protein KIF11	0	1	0	1
HPr kinase/phosphorylase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
ATP-dependent molecular chaperone HSP82	0	0	0	1
Heat shock protein HSP 90-alpha	0	1	2	4
Heat shock protein HSP 90-beta	0	1	1	3
2-dehydropantoate 2-reductase	0	1	1	2
Heat shock 70 kDa protein 1A	0	1	1	2
Endoplasmic reticulum chaperone BiP	0	0	1	1
Heat shock cognate 71 kDa protein	0	0	1	1
Pyruvate kinase PKM	0	0	0	1
Pyruvate kinase PKLR	0	0	0	1
Endoplasmin	0	0	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
5'-nucleotidase	0	1	0	1
Mu-type opioid receptor	0	7	3	10
Delta-type opioid receptor	0	7	2	9
Kappa-type opioid receptor	0	7	2	9
Endoplasmin	0	1	1	2
P2Y purinoceptor 2	0	0	1	1
Phosphatidylinositol 4-kinase alpha	0	2	0	2
P2X purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 4	0	0	1	1
P2X purinoceptor 5	0	0	1	1
P2X purinoceptor 6	0	0	1	1
P2X purinoceptor 3	0	0	1	1
Heat shock protein 75 kDa, mitochondrial	0	1	0	1
P2Y purinoceptor 6	0	0	1	1
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	2
P2Y purinoceptor 11	0	0	1	1
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	2
P2Y purinoceptor 12	0	1	1	2
Sensor protein kinase WalK	0	1	0	1
Phosphatidylinositol 4-kinase beta	0	2	0	2
P2X purinoceptor 2	0	0	1	1
Chain A, PLASMINOGEN	0	0	2	2
Chain A, PLASMINOGEN	0	0	2	2
Chain A, ATP-DEPENDENT DNA HELICASE Q1	9	0	0	9
Chain A, Ferritin light chain	9	0	0	9
Chain A, Apolipoprotein	0	0	1	1
15-lipoxygenase, partial	10	0	0	10
ATAD5 protein, partial	14	0	0	14
cytochrome P450 family 3 subfamily A polypeptide 4	39	0	0	39
EWS/FLI fusion protein	25	0	0	25
nonstructural protein 1	5	0	0	5
arylsulfatase A	13	0	0	13
euchromatic histone-lysine N-methyltransferase 2	47	0	0	47
D(1A) dopamine receptor	7	0	0	7
chromobox protein homolog 1	28	0	0	28
histone acetyltransferase KAT2A isoform 1	19	0	0	19
Rap guanine nucleotide exchange factor 3	9	0	0	9
Plasminogen	0	6	2	8
Proton-coupled amino acid transporter 1	0	4	0	4
Luciferase	20	0	0	20
interleukin 8	17	0	0	17
GLS protein	21	0	0	21
thyroid stimulating hormone receptor	26	0	0	26
estrogen receptor 2 (ER beta)	19	0	0	19
nuclear receptor subfamily 1, group I, member 3	31	0	0	31
pregnane X nuclear receptor	40	0	0	40
G	24	0	0	24
vitamin D (1,25- dihydroxyvitamin D3) receptor	34	0	0	34
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	16	0	0	16
histone deacetylase 9 isoform 3	4	0	0	4
Interferon beta	33	0	0	33
HLA class I histocompatibility antigen, B alpha chain	24	0	0	24
Nicotinate phosphoribosyltransferase	0	5	0	5
Inositol hexakisphosphate kinase 1	24	0	0	24
cytochrome P450 2C9, partial	24	0	0	24
ORF73	0	0	1	1
Chain A, 2-oxoglutarate Oxygenase	16	0	0	16
Microtubule-associated protein tau	26	0	0	26
thioredoxin glutathione reductase	15	0	0	15
Smad3	11	0	0	11
microphthalmia-associated transcription factor isoform 9	0	2	0	2
Tyrosine-protein phosphatase non-receptor type 1	0	1	1	2
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, Beta-lactamase	13	0	0	13
Beta-lactamase	0	0	0	1
apical membrane antigen 1, AMA1	8	0	0	8
farnesoid X nuclear receptor	22	0	0	22
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Metallo-beta-lactamase VIM-11	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	12	0	0	12
DNA polymerase beta	5	0	0	5
60 kDa heat shock protein, mitochondrial	0	1	0	1
Beta-lactamase OXA-7	0	0	0	1
Solute carrier family 15 member 1	0	2	0	2
Solute carrier family 15 member 1	0	1	0	1
Spike glycoprotein	14	2	3	19
10 kDa heat shock protein, mitochondrial	0	1	0	1
Angiopoietin-1 receptor	0	0	1	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
Metallo-beta-lactamase VIM-13	0	1	0	2
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase Toho-1	0	0	0	1
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
60 kDa chaperonin	0	1	0	1
Metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
10 kDa chaperonin	0	1	0	1
Metallo-b-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Histamine H3 receptor	0	1	0	3
Beta-lactamase class B VIM-2	0	0	0	1
Beta-lactamase VIM-1	0	1	0	2
ATP-dependent phosphofructokinase	19	0	0	19
glucocerebrosidase	6	0	0	6
Atrial natriuretic peptide receptor 3	0	1	0	1
Type-1A angiotensin II receptor	0	2	1	3
Type-1 angiotensin II receptor	0	0	1	1
Type-1B angiotensin II receptor	0	2	0	2
Type-1 angiotensin II receptor	0	3	3	6
Type-2 angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	2	0	2
Steroid C26-monooxygenase	0	0	1	1
Cytochrome P450 130	0	0	1	1
Cytochrome P450 130	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
phosphopantetheinyl transferase	23	0	0	23
NFKB1 protein, partial	7	0	0	7
alpha-galactosidase	3	0	0	3
cytochrome P450 2C19 precursor	6	0	0	6
muscarinic acetylcholine receptor M1	13	0	0	13
lethal factor (plasmid)	14	0	0	14
Cytochrome P450 3A4	0	7	1	9
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	1	0	2
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	14	0	0	14
IDH1	15	0	0	15
nuclear factor erythroid 2-related factor 2 isoform 2	14	0	0	15
lethal(3)malignant brain tumor-like protein 1 isoform I	3	0	0	3
Polyphenol oxidase 2	0	4	0	6
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	2
Urease	0	4	0	5
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	6	2	9
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	19	0	0	19
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	16	0	0	16
Chain B, HADH2 protein	16	0	0	16
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
hypothetical protein, conserved	4	0	0	4
cytochrome P450 2D6	25	0	0	25
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
Bloom syndrome protein isoform 1	14	0	0	14
Prostaglandin-H2 D-isomerase	0	2	0	2
ATP-binding cassette sub-family C member 3	0	23	0	23
Multidrug resistance-associated protein 4	0	23	0	24
Solute carrier family 22 member 6	0	3	0	3
Prostaglandin G/H synthase 1	0	3	0	4
Prostaglandin G/H synthase 2	0	2	0	3
Bile salt export pump	0	44	0	44
Epidermal growth factor receptor	0	4	0	4
Fatty acid-binding protein, liver	0	2	0	2
Integrin beta-3	8	2	0	10
Myeloperoxidase	0	3	0	3
Prostaglandin G/H synthase 1	0	5	0	6
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	8	2	0	10
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	7	0	7
Adenosine receptor A1	0	3	0	5
Adenosine receptor A2a	0	3	0	5
Substance-P receptor	0	3	0	4
Prostaglandin G/H synthase 2	0	8	1	9
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	13	0	0	13
Ras-related protein Rab-2A	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	20	2	1	23
Prostaglandin G/H synthase 2	0	5	0	5
Rho-associated protein kinase 2	0	2	0	2
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Canalicular multispecific organic anion transporter 1	0	22	0	22
Sigma non-opioid intracellular receptor 1	0	9	1	10
Sigma non-opioid intracellular receptor 1	0	3	1	4
SMAD family member 2	10	0	0	10
Fumarate hydratase	9	0	0	9
SMAD family member 3	10	0	0	10
polyprotein	9	0	0	9
P53	2	0	0	2
peroxisome proliferator activated receptor gamma	31	0	0	31
aryl hydrocarbon receptor	24	0	0	24
thyroid stimulating hormone receptor	22	0	0	22
peripheral myelin protein 22 isoform 1	9	0	0	9
hemoglobin subunit beta	2	0	0	2
cellular tumor antigen p53 isoform a	12	0	0	12
peripheral myelin protein 22	17	0	0	17
survival motor neuron protein isoform d	19	0	0	19
cytochrome P450 3A4 isoform 1	20	0	0	20
M-phase phosphoprotein 8	8	0	0	8
muscleblind-like protein 1 isoform 1	12	0	0	12
Gamma-aminobutyric acid receptor subunit pi	20	1	1	22
Bile salt export pump	0	7	0	7
Cellular tumor antigen p53	36	0	0	36
Gamma-aminobutyric acid receptor subunit beta-1	20	1	1	22
Gamma-aminobutyric acid receptor subunit delta	20	1	1	22
Gamma-aminobutyric acid receptor subunit gamma-2	20	1	1	22
Gamma-aminobutyric acid receptor subunit alpha-5	20	1	1	22
Gamma-aminobutyric acid receptor subunit alpha-3	20	1	1	22
Gamma-aminobutyric acid receptor subunit gamma-1	20	1	1	22
Gamma-aminobutyric acid receptor subunit alpha-2	20	1	1	22
Gamma-aminobutyric acid receptor subunit alpha-4	20	1	1	22
Gamma-aminobutyric acid receptor subunit gamma-3	20	1	1	22
Gamma-aminobutyric acid receptor subunit alpha-6	20	1	1	22
Gamma-aminobutyric acid receptor subunit beta-3	20	1	1	22
Gamma-aminobutyric acid receptor subunit beta-2	20	1	1	22
GABA theta subunit	20	1	1	22
ATPase family AAA domain-containing protein 5	14	0	0	14
Ataxin-2	19	0	0	19
Gamma-aminobutyric acid receptor subunit epsilon	20	1	1	22
Protein-arginine deiminase type-4	0	2	0	2
Chain A, Integrase	0	1	0	1
Chain A, Integrase	0	1	0	1
Chain A, T4 LYSOZYME	0	0	1	1
Chain A, GCN4P1	0	0	1	1
Chain B, GCN4P1	0	0	1	1
Chain C, GCN4P1	0	0	1	1
Chain A, T4 LYSOZYME	0	0	1	1
Chain A, T4 LYSOZYME	0	0	1	1
Chain A, Replicase polyprotein 1ab	0	1	0	1
Chain A, 3C-like proteinase	0	1	0	1
pregnane X receptor	9	0	0	9
progesterone receptor	28	0	0	28
Endolysin	0	0	2	2
Angiotensin-converting enzyme	0	1	0	2
B2 bradykinin receptor	0	1	0	1
B2 bradykinin receptor	0	2	1	5
B1 bradykinin receptor	0	1	0	1
Olfactory receptor 51E2	0	0	2	2
Mcl-1	0	2	0	2
Muscarinic acetylcholine receptor M1	0	3	1	4
Muscarinic acetylcholine receptor M3	0	3	1	4
Muscarinic acetylcholine receptor M4	0	4	1	5
Muscarinic acetylcholine receptor M5	0	3	1	4
Muscarinic acetylcholine receptor M2	0	3	1	4
ubiquitin carboxyl-terminal hydrolase 2 isoform a	7	0	0	7
Matrix metalloproteinase-9	0	2	0	2
Disintegrin and metalloproteinase domain-containing protein 17	5	0	0	5
potassium voltage-gated channel subfamily H member 2 isoform d	15	0	0	15
Cytochrome P450 2E1	0	1	0	1
GALC protein	6	0	0	6
Thrombopoietin	5	0	0	5
caspase 7, apoptosis-related cysteine protease	5	0	0	5
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	11	0	0	11
bromodomain adjacent to zinc finger domain 2B	17	0	0	17
caspase-3	5	0	0	5
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
Cytochrome P450 2D6	0	8	1	9
Solute carrier organic anion transporter family member 1B3	0	4	0	4
streptokinase A precursor	0	0	1	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	2
30S ribosomal protein S6	0	3	0	3
30S ribosomal protein S7	0	3	0	3
50S ribosomal protein L15	0	3	0	3
50S ribosomal protein L10	0	3	0	3
50S ribosomal protein L11	0	3	0	3
50S ribosomal protein L7/L12	0	3	0	3
50S ribosomal protein L19	0	3	0	3
50S ribosomal protein L1	0	3	0	3
50S ribosomal protein L20	0	3	0	3
50S ribosomal protein L27	0	3	0	3
50S ribosomal protein L28	0	3	0	3
50S ribosomal protein L29	0	3	0	3
50S ribosomal protein L31	0	3	0	3
50S ribosomal protein L31 type B	0	3	0	3
50S ribosomal protein L32	0	3	0	3
50S ribosomal protein L33	0	3	0	3
50S ribosomal protein L34	0	3	0	3
50S ribosomal protein L35	0	3	0	3
50S ribosomal protein L36	0	3	0	3
30S ribosomal protein S10	0	3	0	3
30S ribosomal protein S11	0	3	0	3
30S ribosomal protein S12	0	3	0	3
30S ribosomal protein S13	0	3	0	3
30S ribosomal protein S16	0	3	0	3
30S ribosomal protein S18	0	3	0	3
30S ribosomal protein S19	0	3	0	3
30S ribosomal protein S20	0	3	0	3
30S ribosomal protein S2	0	3	0	3
30S ribosomal protein S3	0	3	0	3
30S ribosomal protein S4	0	3	0	3
30S ribosomal protein S5	0	3	0	3
30S ribosomal protein S8	0	3	0	3
30S ribosomal protein S9	0	3	0	3
50S ribosomal protein L13	0	3	0	3
50S ribosomal protein L14	0	3	0	3
50S ribosomal protein L16	0	3	0	3
50S ribosomal protein L23	0	3	0	3
30S ribosomal protein S15	0	3	0	3
50S ribosomal protein L17	0	3	0	3
50S ribosomal protein L21	0	3	0	3
50S ribosomal protein L30	0	3	0	3
50S ribosomal protein L6	0	3	0	3
30S ribosomal protein S14	0	3	0	3
30S ribosomal protein S17	0	3	0	3
30S ribosomal protein S1	0	3	0	3
50S ribosomal protein L18	0	3	0	3
50S ribosomal protein L2	0	3	0	3
50S ribosomal protein L3	0	3	0	3
50S ribosomal protein L24	0	3	0	3
50S ribosomal protein L4	0	3	0	3
50S ribosomal protein L22	0	3	0	3
50S ribosomal protein L5	0	3	0	3
30S ribosomal protein S21	0	3	0	3
50S ribosomal protein L25	0	3	0	3
50S ribosomal protein L36 2	0	3	0	3
Methionine--tRNA ligase, mitochondrial	0	0	1	1
Carbonic anhydrase 4	0	7	0	10
Carbonic anhydrase	0	4	0	7
Carbonic anhydrase 15	0	5	0	8
Proteasome subunit beta type-11	0	0	0	1
NADPH oxidase 1	0	2	0	2
67.9K protein	9	0	0	9
Snq2p	0	0	0	3
Adenylate cyclase type 1	0	2	0	2
Caspase-7	2	0	0	2
Spike glycoprotein	0	2	3	5
Replicase polyprotein 1ab	0	2	3	5
cytochrome P450 2D6 isoform 1	8	0	0	8
caspase-3	2	0	0	2
mitogen-activated protein kinase 1	10	0	0	10
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
ras-related protein Rab-9A	5	0	0	5
serine/threonine-protein kinase mTOR isoform 1	4	0	0	4
Proteasome subunit alpha type-7	0	0	0	1
Solute carrier family 22 member 1	0	8	0	11
Polyunsaturated fatty acid lipoxygenase ALOX15B	7	0	0	7
Transmembrane protease serine 2	0	2	3	5
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
5-hydroxytryptamine receptor 4	0	12	0	12
Potassium channel subfamily K member 2	0	2	0	2
Albumin	0	1	5	6
Albumin	0	0	2	2
Major prion protein	0	0	2	2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Major prion protein	0	0	1	1
Cytochrome P450 1A2	0	5	1	7
Tyrosine-protein kinase Fyn	0	3	0	3
Procathepsin L	0	3	3	6
Aldo-keto reductase family 1 member B1	0	12	0	12
Muscarinic acetylcholine receptor M2	0	8	1	9
Muscarinic acetylcholine receptor M4	0	6	0	6
ATP-dependent translocase ABCB1	0	9	0	13
5-hydroxytryptamine receptor 1A	0	2	0	2
Muscarinic acetylcholine receptor M5	0	6	0	6
Alpha-2A adrenergic receptor	0	7	2	10
Replicase polyprotein 1a	0	2	3	5
Replicase polyprotein 1ab	0	2	3	5
Replicase polyprotein 1ab	0	2	3	5
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	3	1	4
Replicase polyprotein 1ab	0	2	3	5
Muscarinic acetylcholine receptor M1	0	9	1	10
Cytochrome P450 2C9	0	12	1	13
Polyunsaturated fatty acid lipoxygenase ALOX15	0	7	0	7
Angiotensin-converting enzyme	0	4	0	4
D(2) dopamine receptor	0	9	1	11
Alpha-1B adrenergic receptor	0	12	1	13
Sphingomyelin phosphodiesterase	0	1	0	1
Alpha-2C adrenergic receptor	0	7	2	10
D	0	3	0	3
D(3) dopamine receptor	0	5	0	5
Alpha-2B adrenergic receptor	0	4	1	5
D(2) dopamine receptor	0	1	0	1
Muscarinic acetylcholine receptor M3	0	9	1	10
Proteasome subunit beta type-1	0	0	0	1
Substance-K receptor	0	4	0	4
D(1A) dopamine receptor	0	8	1	10
D(4) dopamine receptor	0	4	0	5
D(1B) dopamine receptor	0	1	0	2
Adenylate cyclase type 3	0	2	0	2
Alpha-2C adrenergic receptor	0	4	1	5
UDP-glucuronosyltransferase 1A4	0	2	0	3
Alpha-2A adrenergic receptor	0	4	1	5
Alpha-1D adrenergic receptor	0	8	1	9
Sodium-dependent noradrenaline transporter	0	12	1	13
Sodium-dependent dopamine transporter	0	3	0	3
Histamine H2 receptor	0	5	2	7
Alpha-1D adrenergic receptor	0	6	2	9
D(1B) dopamine receptor	0	3	0	3
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	2	0	2
Adenylate cyclase type 4	0	2	0	2
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	0	0	1
5-hydroxytryptamine receptor 2A	0	10	1	11
5-hydroxytryptamine receptor 2C	0	12	1	13
Trypanothione reductase	0	4	0	4
D(4) dopamine receptor	0	3	0	3
Histamine H1 receptor	0	2	3	6
Melanocortin receptor 4	0	2	0	2
Melanocortin receptor 5	0	2	0	2
Pleiotropic ABC efflux transporter of multiple drugs	0	3	0	6
5-hydroxytryptamine receptor 7	0	2	1	3
Histamine H1 receptor	0	9	2	11
Glutamate receptor ionotropic, NMDA 1	0	5	2	10
D(3) dopamine receptor	0	8	0	9
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
Adenylate cyclase type 8	0	2	0	2
Proteasome subunit beta type-10	0	0	0	1
5-hydroxytryptamine receptor 2B	0	12	1	13
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	12	1	13
Histamine H2 receptor	13	0	2	16
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
D(1A) dopamine receptor	3	0	0	3
5-hydroxytryptamine receptor 6	0	8	1	9
5-hydroxytryptamine receptor 7	0	5	0	5
Cytochrome P450 2J2	0	6	0	6
Gastrin/cholecystokinin type B receptor	0	1	0	1
Proteasome subunit alpha type-6	0	0	1	2
D(2) dopamine receptor	0	3	0	4
Calmodulin	0	1	2	3
Aldehyde oxidase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	5	2	10
Glutamate receptor ionotropic, NMDA 2B	0	5	2	10
Glutamate receptor ionotropic, NMDA 2C	0	5	2	11
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Sodium-dependent dopamine transporter	0	6	0	6
Adenylate cyclase type 6	0	2	0	2
Adenylate cyclase type 5	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	3	0	3
Aldehyde oxidase	0	3	0	3
Potassium voltage-gated channel subfamily H member 2	0	9	0	9
Glutamate receptor ionotropic, NMDA 2A	0	3	0	3
Glutamate receptor ionotropic, NMDA 2B	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Sodium channel protein type 5 subunit alpha	0	3	0	3
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Sodium channel protein type 9 subunit alpha	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	5	2	10
Nuclear receptor subfamily 3 group C member 3	0	4	0	4
Adenylyl cyclase 7	0	2	0	2
Proteasome subunit alpha-type 8	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	5	2	10
D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Proteasome subunit beta type-7	0	0	0	1
Angiotensin-converting enzyme 2	0	2	3	5
Sodium channel protein type 3 subunit alpha	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	5	2	10
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Histamine H3 receptor	0	2	2	4
Sodium channel protein type 10 subunit alpha	0	1	0	1
endonuclease IV	4	0	0	4
PAX8	0	0	0	1
PPM1D protein	9	0	0	9
nuclear receptor subfamily 1, group I, member 2	6	0	0	6
nuclear receptor subfamily 0 group B member 1	0	1	0	1
cytochrome P450 2C9 precursor	8	0	0	8
steroidogenic factor 1	0	1	0	1
caspase-1 isoform alpha precursor	3	0	0	3
neuropeptide S receptor isoform A	6	0	0	6
Solute carrier family 22 member 3	0	3	0	4
Tubulin alpha-1A chain	0	2	1	3
Tubulin beta chain	0	2	1	3
Plasma kallikrein	0	0	0	4
Tubulin beta-4A chain	0	2	2	5
ATP-dependent translocase ABCB1	0	1	0	1
Tubulin beta chain	0	2	2	5
Tubulin alpha-3C chain	0	2	2	5
Serine/threonine-protein kinase pim-1	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Tubulin alpha-1B chain	0	2	2	5
Tubulin alpha-4A chain	0	2	2	5
Tubulin beta-4B chain	0	2	2	5
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	2	2	5
Tubulin beta-2A chain	0	2	2	5
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	2	2	5
Tubulin beta-2B chain	0	2	0	2
Tubulin alpha-3E chain	0	2	2	5
Tubulin alpha-1A chain	0	2	2	5
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
CREB-binding protein	1	0	0	1
Tubulin alpha-1C chain	0	2	2	5
Tubulin beta-6 chain	0	2	2	5
Tubulin beta-2B chain	0	2	2	5
Tubulin beta-1 chain	0	2	2	5
dopamine D1 receptor	2	0	0	2
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
Glucocorticoid receptor	0	12	2	19
Sex hormone-binding globulin	0	0	5	5
Glycine receptor subunit alpha-1	0	12	0	12
Corticosteroid-binding globulin	0	6	0	6
Glycine receptor subunit beta	0	12	0	12
Glycine receptor subunit alpha-2	0	12	0	12
Glycine receptor subunit alpha-3	0	12	0	12
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
TAR DNA-binding protein 43	12	0	0	12
Multidrug and toxin extrusion protein 1	0	5	0	5
glycogen synthase kinase-3 alpha	0	0	0	1
Exportin-1	0	1	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	3
Carbonic anhydrase 3	0	2	0	5
Cytochrome P450 2A6	0	3	1	5
UDP-glucuronosyltransferase 2B7	0	2	0	2
UDP-glucuronosyltransferase 1-6	0	2	0	2
Amine oxidase [flavin-containing] B	0	4	0	4
Cytochrome P450 2A5	0	1	0	2
Amine oxidase [flavin-containing] A	0	3	0	3
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	4	0	4
UDP-glucuronosyltransferase 1A1	0	3	0	3
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal	0	1	0	1
Carbonic anhydrase 6	0	5	0	8
Carbonic anhydrase 5A, mitochondrial	0	3	0	6
UDP-glucuronosyltransferase 2B10	0	2	0	2
Carbonic anhydrase 7	0	3	0	6
Quinone oxidoreductase	0	0	0	1
Beta-secretase 1	0	1	0	1
Induced myeloid leukemia cell differentiation protein Mcl-1	0	2	0	2
Zn finger protein	0	1	0	1
Dihydroorotate dehydrogenase	0	1	0	1
Carbonic anhydrase 13	0	2	0	3
Carbonic anhydrase 13	0	3	0	5
Carbonic anhydrase 14	0	2	0	5
Carbonic anhydrase 5B, mitochondrial	0	3	0	6
glp-1 receptor, partial	8	0	0	8
RPL19A	0	0	1	1
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
nuclear factor NF-kappa-B p105 subunit isoform 1	2	0	0	2
heat shock protein HSP 90-alpha isoform 2	0	2	0	3
nuclear receptor ROR-gamma isoform 1	15	0	0	15
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
COUP transcription factor 2 isoform a	0	1	0	1
Glucose transporter	0	1	0	1
Hexose transporter 1	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	3	0	3
Solute carrier family 2, facilitated glucose transporter member 1	0	1	0	1
Alpha-synuclein	3	5	0	8
Eukaryotic initiation factor 4A-I	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	0	2
Peptidyl-prolyl cis-trans isomerase FKBP3	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP4	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	1	0	1
Hypoxia-inducible factor 1-alpha	0	1	0	1
Endothelial PAS domain-containing protein 1	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP14	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4	0	1	0	1
heat shock protein 90, putative	0	0	0	1
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	11	0	0	11
RAD51	0	1	0	1
huntingtin isoform 2	4	0	0	4
histone-lysine N-methyltransferase 2A isoform 2 precursor	6	0	0	6
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1	0	1	0	1
Caspase-7	2	0	0	2
Growth factor receptor-bound protein 2	0	1	0	1
Pantothenate synthetase	0	2	0	2
Discoidin domain-containing receptor 2	0	1	0	1
Growth factor receptor-bound protein 2	0	1	0	1
Reverse transcriptase/RNaseH	0	1	0	1
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase	0	0	1	1
Solute carrier family 22 member 3	0	1	0	1
Solute carrier family 22 member 2	0	6	0	7
NAD	0	1	0	1
Cholinesterase	0	3	0	3
NAD	0	2	0	3
Mitogen-activated protein kinase 1	0	1	0	1
ATP phosphoribosyltransferase	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
G-protein coupled receptor 35	0	1	1	2
high affinity choline transporter 1 isoform a	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	2	1	0	3
Nuclear receptor subfamily 1 group I member 2	0	1	4	5
Estrogen receptor	0	8	2	11
Beta-1 adrenergic receptor	0	6	2	8
Adenosine receptor A3	0	5	1	6
Androgen receptor	0	9	0	9
Thromboxane-A synthase	0	2	0	2
Adenosine receptor A2a	0	3	1	4
Adenosine receptor A1	0	2	0	2
Vasopressin V1a receptor	0	3	1	4
Estrogen-related receptor gamma	0	0	1	1
UDP-glucose 4-epimerase	0	1	0	1
Estrogen receptor beta	0	5	2	8
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	3	1	4
Cysteinyl leukotriene receptor 1	0	2	0	2
Cereblon isoform 4	0	4	0	4
Insulin-like growth factor-binding protein 5	0	0	1	1
Choline O-acetyltransferase	0	1	0	1
Protein cereblon	0	6	1	8
prostaglandin E2 receptor EP2 subtype	1	0	0	1
Solute carrier family 22 member 2	0	3	0	6
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Prostaglandin E2 receptor EP3 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	0	2
Prostaglandin E2 receptor EP1 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP3 subtype	0	2	1	3
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Prostacyclin receptor	0	2	1	3
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier family 22 member 6	0	2	0	4
Solute carrier family 22 member 7	0	0	0	2
Prostaglandin E2 receptor EP2 subtype	0	2	0	2
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 8	0	3	0	5
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier family 22 member 11	0	0	0	2
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier family 22 member 7	0	0	0	2
Histamine N-methyltransferase	0	0	0	1
Solute carrier family 22 member 1	0	5	0	7
Calcium release-activated calcium channel protein 1	0	1	0	1
Protein orai-2	0	1	0	1
Protein orai-3	0	1	0	1
Histamine H4 receptor	0	2	2	4
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
RGS12	1	0	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	2	0	2
DNA polymerase III, partial	1	0	0	1
isocitrate dehydrogenase 1, partial	4	0	0	4
LANA	0	0	0	1
NPYLR7B	0	0	2	2
thyrotropin-releasing hormone receptor	5	0	0	5
serine-protein kinase ATM isoform a	4	0	0	4
lysosomal alpha-glucosidase preproprotein	5	0	0	5
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	1	0	0	1
eyes absent homolog 2 isoform a	2	0	0	2
tumor susceptibility gene 101 protein	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	2	0	0	2
kelch-like ECH-associated protein 1	0	0	0	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Multidrug resistance-associated protein 5	0	2	0	2
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-4	3	3	3	10
Neuronal acetylcholine receptor subunit beta-2	3	3	3	10
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	0	1	0	1
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Exopolyphosphatase PRUNE1	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Equilibrative nucleoside transporter 1	0	2	0	2
Single-stranded DNA cytosine deaminase	2	0	0	2
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	0	1	0	1
Phosphodiesterase	0	1	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	1
Eyes absent homolog 2	0	1	0	1
Amyloid-beta precursor protein	0	4	0	4
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Genome polyprotein	0	1	1	2
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
relaxin receptor 1 isoform 1	1	0	0	1
Flavin reductase (NADPH)	0	0	1	1
large T antigen	0	2	0	2
hexokinase-4 isoform 1	2	0	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	7	0	0	7
glucokinase regulatory protein	2	0	0	2
Steryl-sulfatase	0	1	0	1
Aromatase	0	1	0	1
17-beta-hydroxysteroid dehydrogenase type 1	0	2	0	3
Mu-type opioid receptor	0	3	2	5
Solute carrier organic anion transporter family member 1A1	0	2	0	2
Mu-type opioid receptor	0	3	1	4
Cytochrome P450 1B1	0	1	0	1
Ghrelin O-acyltransferase	0	1	0	1
Protease	0	4	0	4
Amine oxidase [flavin-containing] A	0	7	0	7
Amine oxidase [flavin-containing] B	0	6	1	7
Delta-type opioid receptor	0	3	0	4
Delta-type opioid receptor	0	3	0	3
Kappa-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	1	0	2
Sigma non-opioid intracellular receptor 1	0	2	0	2
Menin	0	0	1	1
Lecithin retinol acyltransferase	0	1	0	1
Lethal factor	0	1	0	1
Protein Rev	0	0	1	1
Aminoglycoside 3'-phosphotransferase	0	0	0	1
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
Fucose-binding lectin PA-IIL	0	2	0	2
CD209 antigen	0	3	0	3
Beta-galactosidase	0	1	0	1
Lipopolysaccharide heptosyltransferase 1	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Jacalin	0	0	1	1
Glycogen phosphorylase, muscle form	0	1	0	1
Asialoglycoprotein receptor 1	0	1	1	2
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	3	0	3
Serine racemase	0	1	0	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Chain E, Fibrin beta chain	0	2	0	2
WRN	2	0	0	2
MPI protein	0	1	0	1
Cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0	0	0	1
alkaline phosphatase, intestinal	0	0	1	1
luciferase	2	0	0	2
pyruvate kinase	1	0	0	1
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
CDK5	0	0	0	1
major prion protein preproprotein Prp precursor	0	1	0	1
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	0	1	1
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
intestinal alkaline phosphatase precursor	0	0	1	1
Vif	0	1	0	1
Tat	0	1	0	1
alkaline phosphatase, germ cell type preproprotein	0	0	1	1
endoribonuclease toxin MazF	0	0	1	1
Pyruvate kinase PKM	0	1	1	2
Endothelin receptor type B	1	0	0	1
Endothelin-1 receptor	1	1	0	2
phosphoglycerate kinase	3	0	0	3
hypothetical protein CAALFM_CR05890CA	0	0	0	1
H3 histone acetyltransferase	0	0	0	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Macrophage migration inhibitory factor	0	3	0	3
5-hydroxytryptamine receptor 1D	0	0	0	1
Histamine H1 receptor	0	2	1	3
Metabotropic glutamate receptor 5	0	1	1	2
Carbonic anhydrase	0	0	0	4
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase	0	1	0	5
Carbonic anhydrase-like protein, putative	0	0	0	3
Carbonic anhydrase	0	1	0	5
Carbonic anhydrase	0	1	0	5
Carbonic anhydrase	0	0	0	4
Equilibrative nucleoside transporter 4	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 4	0	0	0	1
Carboxylic ester hydrolase	0	0	0	1
Neutral amino acid transporter A	0	2	0	2
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	2	0	2
Amino acid transporter	0	2	0	2
Chain A, Cell Division Protein Kinase 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, Cell Division Protein Kinase 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, Cell Division Protein Kinase 2	0	1	0	1
DNA repair and recombination protein RadA	0	0	1	1
Cyclin-dependent kinase 1	0	1	0	1
G2/mitotic-specific cyclin-B1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	2	1	4
RAC-alpha serine/threonine-protein kinase	0	1	0	1
Cyclin-A1	0	1	0	1
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
Parkin	2	0	0	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	3	0	0	3
Prostaglandin E synthase	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Cytochrome c oxidase subunit 2	0	1	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Interleukin-8	0	1	0	1
Androgen receptor	0	2	1	3
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	3
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Serum paraoxonase/arylesterase 1	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Caspase-1	0	0	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Bifunctional epoxide hydrolase 2	0	2	0	2
Prostaglandin G/H synthase 2	0	3	0	3
Peroxisome proliferator-activated receptor gamma	0	0	3	3
Aldo-keto reductase family 1 member C3	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
C-X-C chemokine receptor type 3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Lactoylglutathione lyase	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	3
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
Solute carrier organic anion transporter family member 1B1	0	2	0	3
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
N-glycosylase/DNA lyase	0	1	0	1
Formamidopyrimidine-DNA glycosylase	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Cytochrome P450 2C8	0	3	0	3
Cytochrome P450 2C19	0	4	0	4
Endonuclease III-like protein 1	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	2
Isocitrate lyase	0	1	0	1
Putative FAD-containing monooxygenase MymA	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Endonuclease 8-like 1	0	1	0	1
Beta-1 adrenergic receptor	0	1	2	5
beta-2 adrenergic receptor	1	0	0	1
Beta-2 adrenergic receptor	0	4	3	8
Beta-2 adrenergic receptor	0	4	1	6
Beta-3 adrenergic receptor	0	3	2	5
Beta-1 adrenergic receptor	0	4	2	8
Beta-2 adrenergic receptor	0	0	1	1
Beta-adrenergic receptor kinase 1	0	0	1	1
Beta-3 adrenergic receptor	0	0	1	1
Beta-3 adrenergic receptor	0	3	1	4
Vasopressin V1a receptor	0	0	1	1
Beta-1 adrenergic receptor	0	2	1	3
Alpha-1A adrenergic receptor	0	1	3	5
Alpha-1B adrenergic receptor	0	0	2	3
Beta-2 adrenergic receptor	0	2	0	2
Taste receptor type 2 member 38	0	0	2	3
Taste receptor type 2 member 39	0	0	1	1
Taste receptor type 2 member 40	0	0	1	1
Taste receptor type 2 member 41	0	0	1	1
Taste receptor type 2 member 43	0	0	1	1
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 45	0	0	1	1
Taste receptor type 2 member 46	0	0	1	1
Taste receptor type 2 member 30	0	0	1	1
Taste receptor type 2 member 19	0	0	1	1
Taste receptor type 2 member 20	0	0	1	1
Taste receptor type 2 member 50	0	0	1	1
Taste receptor type 2 member 60	0	0	1	1
Oxytocin receptor	0	0	1	1
Beta-2 adrenergic receptor	0	1	1	2
Taste receptor type 2 member 42	0	0	1	1
Beta-2 adrenergic receptor	0	1	3	5
Taste receptor type 2 member 16	0	0	1	1
Taste receptor type 2 member 14	0	0	1	2
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 10	0	0	1	1
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 8	0	0	1	1
Taste receptor type 2 member 7	0	0	1	1
Taste receptor type 2 member 5	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Taste receptor type 2 member 3	0	0	1	1
Taste receptor type 2 member 1	0	0	1	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
transcriptional regulator ERG isoform 3	4	0	0	4
Alpha-mannosidase 2C1	0	1	0	1
Acetylcholine receptor subunit alpha	0	2	2	4
Neuronal acetylcholine receptor subunit alpha-3	0	2	3	6
Acetylcholine receptor subunit gamma	0	2	2	4
Acetylcholine receptor subunit beta	0	2	2	4
Neuronal acetylcholine receptor subunit alpha-2	0	2	3	6
Neuronal acetylcholine receptor subunit beta-3	0	2	3	6
Neuronal acetylcholine receptor subunit beta-4	0	2	3	6
Neuronal acetylcholine receptor subunit beta-2	0	3	1	5
Neuronal acetylcholine receptor subunit alpha-5	0	2	3	6
Neuronal acetylcholine receptor subunit beta-4	0	3	1	5
Neuronal acetylcholine receptor subunit alpha-3	0	3	1	4
Neuronal acetylcholine receptor subunit alpha-7	0	3	2	5
Neuronal acetylcholine receptor subunit alpha-6	0	2	3	6
Neuronal acetylcholine receptor subunit alpha-9	0	2	3	6
Neuronal acetylcholine receptor subunit alpha-4	0	3	1	5
Acetylcholine receptor subunit epsilon	0	0	2	2
Neuronal acetylcholine receptor subunit alpha-7	0	2	3	6
Acetylcholine receptor subunit delta	0	2	2	4
Neuronal acetylcholine receptor subunit alpha-2	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-10	0	2	3	6
UDP-glucose 6-dehydrogenase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
UDP-glucose 6-dehydrogenase	0	1	0	1
Purine nucleoside phosphorylase	0	0	1	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7	0	0	0	1
Cannabinoid receptor 1	0	4	0	4
galanin receptor type 3	0	1	0	1
T cell receptor, partial	1	0	0	1
luteinizing hormone receptor	1	0	0	1
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
TSHR protein	1	0	0	1
Apoptotic peptidase activating factor 1	0	1	0	1
neutrophil cytosol factor 1	0	1	0	1
caspase-9 isoform alpha precursor	0	1	0	1
pyruvate kinase PKM isoform a	1	0	0	1
caspase-3 isoform a preproprotein	0	1	0	1
protein AF-9 isoform a	0	0	0	1
Vpr	1	0	0	1
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
POsterior Segregation	0	0	1	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
Glutathione reductase	0	1	0	1
Glutathione reductase, mitochondrial	0	1	0	2
Glycoprotein hormones alpha chain	1	0	0	1
Dihydrolipoyl dehydrogenase, mitochondrial	0	1	0	2
Microtubule-associated protein tau	0	1	1	2
Cruzipain	0	1	0	1
Thioredoxin reductase 1, cytoplasmic	0	1	0	2
Dihydrolipoyl dehydrogenase	0	1	0	2
Zinc finger protein mex-5	0	0	1	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Lanosterol 14-alpha demethylase	0	3	0	3
Histone deacetylase 3	0	2	0	2
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Integrin alpha-4	0	1	0	1
Histone deacetylase 4	0	1	0	1
Histone deacetylase 1	0	2	0	2
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	2	0	2
Histone deacetylase 11	0	1	0	1
Histone deacetylase 8	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 5	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
Formyl peptide receptor-related sequence 1	0	0	1	1
fMet-Leu-Phe receptor	0	3	2	5
N-formyl peptide receptor 2	0	0	2	2
FML2_HUMAN	0	0	1	1
Ubiquitin-like modifier activating enzyme 2	0	1	0	1
SUMO1 activating enzyme subunit 1	0	1	0	1
ubiquitin-like modifier-activating enzyme 1	0	1	0	1
SUMO-conjugating enzyme UBC9	0	1	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
ubiquitin-conjugating enzyme E2 variant 1 isoform a	0	1	0	1
Prothrombin	0	1	0	1
Complement C1r subcomponent	0	1	0	1
Coagulation factor X	0	1	0	1
Coagulation factor XII	0	1	0	1
Cationic trypsin	0	1	0	1
Interstitial collagenase	0	1	0	1
Serine protease hepsin	0	2	0	2
Cathepsin D	0	1	0	1
Trypsin-1	0	1	0	1
72 kDa type IV collagenase	0	3	0	3
Complement C1s subcomponent	0	1	0	1
Neutrophil collagenase	0	2	0	2
Collagenase 3	0	2	0	2
Hepatocyte growth factor activator	0	2	1	3
Suppressor of tumorigenicity 14 protein	0	1	0	1
Acetylcholinesterase	0	4	0	4
Cholinesterase	0	2	0	2
Cholesteryl ester transfer protein	0	1	0	1
D-amino-acid oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 3	0	0	1	1
Nicotinamidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	0	1	1
Hydroxycarboxylic acid receptor 2	0	2	1	3
D-aspartate oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	1	1	2
5-hydroxytryptamine receptor 3E	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit beta	0	2	1	3
Acetylcholine receptor subunit gamma	0	2	1	3
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Translocator protein	0	1	0	1
Acetylcholine receptor subunit beta-like 2	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-5	0	0	1	1
Muscarinic acetylcholine receptor M4	0	1	1	3
5-hydroxytryptamine receptor 3A	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Acetylcholine-binding protein	0	1	1	2
Neuronal acetylcholine receptor subunit beta-3	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-6	0	1	1	2
Cytochrome P450 2A13	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-5	0	2	0	2
Liver carboxylesterase B-1	0	1	0	1
5-hydroxytryptamine receptor 3D	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Soluble acetylcholine receptor	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-6	0	2	0	2
Integrin beta	0	0	1	1
Glycoprotein IIb	0	0	1	1
Transporter	0	1	1	3
Valosin-containing protein	0	1	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
Pyrroline-5-carboxylate reductase 1, mitochondrial	0	1	0	1
Renin	0	1	0	1
Cytochrome P450 1A2	0	0	0	2
Arylacetamide deacetylase	0	0	0	1
Arylacetamide deacetylase	0	0	0	1
Arylacetamide deacetylase	0	0	0	1
Chain A, Immunoglobulin	0	0	1	1
Chain B, Immunoglobulin	0	0	1	1
Muscarinic acetylcholine receptor M1	0	0	1	2
Cytochrome P450 2B6	0	1	0	1
Kappa-type opioid receptor	0	0	0	1
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Cholinesterase	0	1	0	1
Muscarinic acetylcholine receptor M5	0	0	1	2
Muscarinic acetylcholine receptor M3	0	0	1	2
Muscarinic acetylcholine receptor M2	0	0	1	2
Lysine-specific histone demethylase 1A	0	1	0	1
Membrane primary amine oxidase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Lysozyme	0	0	1	1
Chain A, Lysozyme	0	0	1	1
Chain A, Lysozyme	0	0	1	1
Chain A, Lysozyme	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	1	1
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-2	0	0	1	1
Carbonic anhydrase	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase 3	0	2	0	2
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
rac GTPase-activating protein 1 isoform a	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Estrogen receptor 1	0	1	0	1
fMet-Leu-Phe receptor	0	2	0	2
Cyclooxygenase-2	0	1	0	1
luciferase	0	0	0	1
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Chloroquine resistance transporter	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Endothelin-1 receptor	0	3	1	4
5-hydroxytryptamine receptor 1B	0	2	1	3
Neuromedin-K receptor	0	0	1	1
Cholecystokinin receptor type A	0	1	1	2
Sodium/bile acid cotransporter	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
Pyridoxal kinase	0	0	0	1
runt-related transcription factor 1 isoform AML1b	1	0	0	1
core-binding factor subunit beta isoform 2	1	0	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Sucrase-isomaltase, intestinal	0	1	0	1
Autoinducer 2-binding periplasmic protein LuxP	0	1	0	1
5-lipoxygenase	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	2
Solute carrier family 22 member 2	0	1	0	1
Histidine-rich protein PFHRP-II	0	1	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
Cytochrome P450 2D4	0	1	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Peroxisome proliferator-activated receptor alpha	1	0	1	2
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
Solute carrier family 22 member 12	0	1	0	1
Hematopoietic prostaglandin D synthase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
Stromelysin-1	0	2	0	2
Multidrug transporter MdfA	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Alcohol dehydrogenase E chain	0	1	0	1
Alcohol dehydrogenase S chain	0	1	0	1
Urease subunit alpha	0	1	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Urease subunit beta	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Thymidine kinase	0	1	0	2
Thymidine kinase, cytosolic	0	2	0	4
Thymidine kinase	0	1	0	2
Thymidylate synthase	0	0	0	1
Thymidine phosphorylase	0	0	0	1
Thymidine phosphorylase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	1	0	2
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	0	0	1
Thymidine kinase	0	0	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Retinoic acid receptor RXR-alpha	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Urokinase-type plasminogen activator	0	1	0	1
procathepsin L isoform 1 preproprotein	0	1	0	1
Carboxypeptidase A1	0	1	0	1
Thermolysin	0	1	0	1
Dopamine beta-hydroxylase	0	1	0	1
Collagenase ColG	0	1	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Dihydrofolate reductase	0	2	0	2
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Tryptophan 2,3-dioxygenase	0	1	0	2
SLC16A10 protein	0	0	0	2
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Monocarboxylate transporter 10	0	0	0	2
Phospholipase A-2-activating protein	0	1	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Tubulin--tyrosine ligase	0	1	0	1
Chain A, Uracil-DNA Glycosylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(4)

Research Excerpts

Overview

Treatment

Research

Studies (438)

Protein Targets (1,372)

Schwartzman Phenomenon

Synonyms(4)

Research Excerpts

Overview

Treatment

Research

Studies (438)

Drugs Studied (229)

Protein Targets (1,372)