ascorbic-acid and Urination-Disorders

Present knowledge concerning carcinogenesis and the natural history of urothelial tumours precludes firm conclusions relative to nonindustrial prophylaxis. However, a number of measures are consistent with current data and may be instituted for those patients with a demonstrated propensity to urothelial tumours. Their acceptability is based on the lack of associated toxicity for the patient. These measures include the elimination of significant infection, cigarettes, artificial sweeteners, analgesic abuse and coffee, the administration of vitamins C and B(6), and in selected cases, the use of thiotepa. It is emphasized that the merit of these steps in altering the natural history of urothelial tumours is uncertain.

Topics: Analgesics; Ascorbic Acid; Coffee; Female; Humans; Male; Papilloma; Pyridoxine; Sex Factors; Smoking; Sweetening Agents; Thiotepa; Urethral Stricture; Urinary Bladder Neoplasms; Urinary Tract Infections; Urination Disorders

To evaluate the association of serum micronutrients with lower urinary tract symptoms (LUTS).. We included 2497 men, 60 years old and older, who participated in the Third National Health and Nutrition Examination Survey from 1988 to 1994 and for whom serum concentrations of vitamins A, C, and E, carotenoids, and selenium had been measured previously. Cases were men with three or four of the following symptoms: nocturia, hesitancy, incomplete emptying, and weak stream, but who had never undergone noncancer prostate surgery. Controls were men without symptoms, who had never undergone noncancer prostate surgery. We adjusted for age and race in logistic regression models and used sampling weights.. Serum concentrations of vitamin E (P = 0.03), lycopene (P = 0.06), and selenium (P = 0.03) were lower in men with LUTS compared with controls. Men in the top four quintiles of vitamin E, lycopene, and selenium had a nonstatistically significant 25% to 50% reduced odds of LUTS compared with men in the bottom quintile. Inverse associations were not seen for the other carotenoids or vitamin A. A high serum vitamin C concentration was associated with a lower odds of LUTS in current smokers, but with a nonstatistically significant greater odds in those who never smoked and in former smokers.. Greater circulating concentrations of vitamin E, lycopene, and selenium, antioxidant micronutrients that are supported in published reports as protecting against prostate cancer, were observed also to be inversely associated with LUTS. The effect modification of the association with vitamin C by cigarette smoking warrants additional examination.

Topics: Aged; Antioxidants; Ascorbic Acid; beta Carotene; Carotenoids; Cross-Sectional Studies; Cryptoxanthins; Humans; Lutein; Lycopene; Male; Micronutrients; Middle Aged; Selenium; Smoking; Surveys and Questionnaires; Urination Disorders; Vitamin A; Vitamin E; Xanthophylls; Zeaxanthins

Topics: Angiography; Animals; Ascorbic Acid; Blood Vessels; Cats; Female; Humans; Intervertebral Disc; Male; Methenamine; Motor Neurons; Myelography; Nerve Tissue; Neuroradiography; Paraplegia; Pressure; Quadriplegia; Rabbits; Spinal Canal; Spinal Cord Compression; Spinal Cord Injuries; Spinal Cord Neoplasms; Urinary Catheterization; Urinary Tract Infections; Urination Disorders; Urologic Diseases

Topics: Animals; Ascorbic Acid; Burns; Dogs; Oliguria; Urination Disorders; Vitamins