Roles > food antioxidant
Page last updated: 2024-08-05 15:20:00

food antioxidant

An antioxidant that used as a food additives to help guard against food deterioration.

ChEBI ID: 77962

Members (9)

MemberDefinitionClass
2-tert-butylhydroquinoneA member of the class of hydroquinones in which one of the ring hydrogens of hydroquinone is replaced by a tert-butyl group.2-tert-butylhydroquinone
ascorbic acidThe L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.L-ascorbic acid
delta-tocopherolA tocopherol in which the chroman-6-ol core is substituted by a methyl group at position 8. It is found particularly in maize (corn) oil and soya bean (soybean) oils.delta-tocopherol
ethoxyquinA quinoline that is 1,2-dihydroquinoline bearing three methyl substituents at position 2, 2 and 4 as well as an ethoxy substituent at position 6.ethoxyquin
gamma-tocopherolA tocopherol in which the chroman-6-ol core is substituted by methyl groups at positions 7 and 8. It is found particularly in maize (corn) oil and soya bean (soybean) oils.gamma-tocopherol
octyl gallateA gallate ester obtained by condensation of the carboxy group of gallic acid with the hydroxy group of octanol.octyl gallate
sodium bisulfiteAn inorganic sodium salt having hydrogensulfite as the counterion.sodium hydrogensulfite
sodium metabisulfiteAn inorganic sodium salt composed of sodium and disulfite ions in a 2:1 ratio.sodium disulfite
sodium nitriteAn inorganic sodium salt having nitrite as the counterion. Used as a food preservative and antidote to cyanide poisoning.sodium nitrite

Research

Studies (45,628)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-199016,273 (35.66)18.7374
1990's6,179 (13.54)18.2507
2000's9,642 (21.13)29.6817
2010's10,056 (22.04)24.3611
2020's3,478 (7.62)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials2,650 (5.35%)5.53%
Reviews2,820 (5.70%)6.00%
Case Studies967 (1.95%)4.05%
Observational51 (0.10%)0.25%
Other43,029 (86.90%)84.16%

Protein Targets (144)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency17.073913
15-lipoxygenase, partialHomo sapiens (human)Potency20.678116
acetylcholinesteraseHomo sapiens (human)Potency55.380937
acid sphingomyelinaseHomo sapiens (human)Potency25.118911
activating transcription factor 6Homo sapiens (human)Potency48.348126
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency13.548217
apical membrane antigen 1, AMA1Plasmodium falciparum 3D7Potency22.387211
AR proteinHomo sapiens (human)Potency26.02951038
aryl hydrocarbon receptorHomo sapiens (human)Potency26.2380317
bromodomain adjacent to zinc finger domain 2BHomo sapiens (human)Potency50.118711
caspase 7, apoptosis-related cysteine proteaseHomo sapiens (human)Potency76.958811
caspase-3Cricetulus griseus (Chinese hamster)Potency46.122013
caspase-3Homo sapiens (human)Potency76.958811
Caspase-7Cricetulus griseus (Chinese hamster)Potency46.122013
Cellular tumor antigen p53Homo sapiens (human)Potency32.9095311
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency18.854112
Chain A, HADH2 proteinHomo sapiens (human)Potency17.434429
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency44.668411
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency0.501211
Chain A, Putative fructose-1,6-bisphosphate aldolaseGiardia intestinalisPotency17.740711
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency25.839313
Chain B, HADH2 proteinHomo sapiens (human)Potency17.434429
chromobox protein homolog 1Homo sapiens (human)Potency100.000011
cytochrome P450 2C19 precursorHomo sapiens (human)Potency0.050111
cytochrome P450 2C9 precursorHomo sapiens (human)Potency4.969312
cytochrome P450 2C9, partialHomo sapiens (human)Potency18.089413
cytochrome P450 2D6Homo sapiens (human)Potency16.933011
cytochrome P450 2D6 isoform 1Homo sapiens (human)Potency2.511911
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency14.219124
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency16.836824
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency38.487413
estrogen nuclear receptor alphaHomo sapiens (human)Potency29.75381241
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency40.847825
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency24.1067612
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency8.656213
farnesoid X nuclear receptorHomo sapiens (human)Potency53.156622
flap endonuclease 1Homo sapiens (human)Potency35.481311
GVesicular stomatitis virusPotency18.089413
GABA theta subunitRattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency14.219112
gemininHomo sapiens (human)Potency14.180925
GLI family zinc finger 3Homo sapiens (human)Potency21.5968214
GLS proteinHomo sapiens (human)Potency22.387211
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency28.6399517
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency14.596212
heat shock protein beta-1Homo sapiens (human)Potency57.563725
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency14.3918214
Histone H2A.xCricetulus griseus (Chinese hamster)Potency66.423728
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency18.089413
huntingtin isoform 2Homo sapiens (human)Potency25.118911
hypothetical protein, conservedTrypanosoma bruceiPotency31.622811
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency43.641222
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)Homo sapiens (human)Potency1.258922
IDH1Homo sapiens (human)Potency5.173511
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency18.089416
Interferon betaHomo sapiens (human)Potency18.089413
interleukin 8Homo sapiens (human)Potency66.824211
lamin isoform A-delta10Homo sapiens (human)Potency3.433915
lethal factor (plasmid)Bacillus anthracis str. A2012Potency1.756012
lethal(3)malignant brain tumor-like protein 1 isoform IHomo sapiens (human)Potency0.631011
LuciferasePhotinus pyralis (common eastern firefly)Potency56.617924
Nrf2Homo sapiens (human)Potency19.952611
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency33.8859424
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency20.596211
nuclear factor NF-kappa-B p105 subunit isoform 1Homo sapiens (human)Potency50.118711
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency35.045723
Nuclear receptor ROR-gammaHomo sapiens (human)Potency34.026514
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency13.766428
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency33.9077314
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency12.182224
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency37.8123516
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency40.717459
phosphopantetheinyl transferaseBacillus subtilisPotency31.850913
polyunsaturated fatty acid lipoxygenase ALOX12Homo sapiens (human)Potency12.589311
Polyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)Potency21.458714
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency28.183811
pregnane X nuclear receptorHomo sapiens (human)Potency41.4128310
pregnane X receptorRattus norvegicus (Norway rat)Potency45.857712
progesterone receptorHomo sapiens (human)Potency30.715113
RAR-related orphan receptor gammaMus musculus (house mouse)Potency19.345929
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency44.4324316
retinoid X nuclear receptor alphaHomo sapiens (human)Potency29.0859311
SMAD family member 2Homo sapiens (human)Potency41.973625
SMAD family member 3Homo sapiens (human)Potency41.973625
Smad3Homo sapiens (human)Potency2.238711
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency3.700812
TDP1 proteinHomo sapiens (human)Potency19.334527
thioredoxin glutathione reductaseSchistosoma mansoniPotency55.756212
thioredoxin reductaseRattus norvegicus (Norway rat)Potency89.125111
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency35.2706317
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency45.096824
USP1 protein, partialHomo sapiens (human)Potency31.024923
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency40.373028
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency43.4002514
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency42.136613
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency14.596212
VprHuman immunodeficiency virus 1Potency0.794311

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
AlbuminBos taurus (cattle)IC50155.380011
Aldo-keto reductase family 1 member A1Homo sapiens (human)IC50100.000011
Aldo-keto reductase family 1 member B1Homo sapiens (human)IC50100.000011
Aldo-keto reductase family 1 member B10Homo sapiens (human)IC50100.000011
Aldo-keto reductase family 1 member C1Homo sapiens (human)IC505.480011
Aldo-keto reductase family 1 member C2 Homo sapiens (human)IC509.280011
Aldo-keto reductase family 1 member C3Homo sapiens (human)IC502.560011
Aldo-keto reductase family 1 member C4Homo sapiens (human)IC504.040011
Carbonic anhydraseMethanosarcina thermophilaKi8,760.000035
Carbonic anhydrase Astrosclera willeyanaKi32,060.000012
Carbonic anhydrase Pseudomonas aeruginosa PAO1Ki3,970.000012
Carbonic anhydrase 1Homo sapiens (human)Ki12,880.0000815
Carbonic anhydrase 2Homo sapiens (human)Ki75,235.29411834
Carbonic anhydrase 4Homo sapiens (human)Ki30,800.000011
Carbonic anhydrase 5A, mitochondrialHomo sapiens (human)Ki16,000.000011
Chain A, Hyaluronidase, phage associatedStreptococcus pyogenesIC501,000.000011
Estrogen receptorHomo sapiens (human)IC508.740011
Hyaluronate lyaseStreptococcus pneumoniae TIGR4IC506,000.000011
Mu-type opioid receptorRattus norvegicus (Norway rat)Ki76,000.000012
Pancreatic alpha-amylaseRattus norvegicus (Norway rat)IC5026.500011
Pancreatic alpha-amylaseRattus norvegicus (Norway rat)Ki43.400011
Polyphenol oxidase 2Agaricus bisporusIC50253.400055
Solute carrier family 23 member 1Homo sapiens (human)IC50156.000011
Squalene monooxygenase Rattus norvegicus (Norway rat)IC500.830011
TyrosinaseHomo sapiens (human)IC5043.350012
UreaseCanavalia ensiformis (jack bean)IC508.590011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Alpha-2B adrenergic receptorHomo sapiens (human)EC500.000511
Nuclear factor erythroid 2-related factor 2Homo sapiens (human)EC5091.530011
Nuclear receptor subfamily 1 group I member 2Homo sapiens (human)EC507.300022

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Egl nine homolog 1Homo sapiens (human)Km180.000011
Hypoxia-inducible factor 1-alpha inhibitorHomo sapiens (human)Km260.000011
Nuclear factor erythroid 2-related factor 2Homo sapiens (human)Activity2.081766
Nuclear factor erythroid 2-related factor 2Homo sapiens (human)CD1.680011
Prolyl 4-hydroxylase subunit alpha-1Homo sapiens (human)Km300.000011
Prolyl hydroxylase EGLN2Homo sapiens (human)Km170.000011
Prolyl hydroxylase EGLN3Homo sapiens (human)Km140.000011