Page last updated: 2024-09-28

Chronic Progressive External Ophthalmoplegia with Myopathy

A mitochondrial disorder featuring the triad of chronic progressive EXTERNAL OPHTHALMOPLEGIA, cardiomyopathy (CARDIOMYOPATHIES) with conduction block (HEART BLOCK), and RETINITIS PIGMENTOSA. Disease onset is in the first or second decade. Elevated CSF protein, sensorineural deafness, seizures, and pyramidal signs may also be present. Ragged-red fibers are found on muscle biopsy. (Adams et al., Principles of Neurology, 6th ed, p984)

Synonyms(16)

Synonym
Cpeo With Ragged-Red Fibers
CPEO with Ragged Red Fibers
Kearns-Sayre Syndrome
CPEO with Myopathy
Kearns' Syndrome
Kearns-Sayre-Shy-Daroff Syndrome
Kearns-Sayre Mitochondrial Cytopathy
Kearns Syndrome
Kearns Sayre Syndrome
Oculocraniosomatic Syndrome
Ophthalmoplegia, Progressive External, With Ragged-Red Fibers
Chronic Progressive External Ophthalmoplegia with Myopathy
Ophthalmoplegia Plus Syndrome
Ophthalmoplegia-Plus Syndrome
Ophthalmoplegia, Pigmentary Degeneration of Retina, and Cardiomyopathy
Kearn-Sayre Mitochondrial Cytopathy

Research

Studies (104)

TimeframeStudies, This Condition (%)All Conditions %
pre-199028 (26.92)23.3326
1990's35 (33.65)12.5806
2000's19 (18.27)18.1394
2010's18 (17.31)28.8240
2020's4 (3.85)9.53
DrugIndicatedRelationship StrengthStudiesTrials
alpha-ketoadipic acid0low10
adenine0low10
carnitine0low50
choline0low20
3-hydroxybutyric acid0low20
2-aminoadipic acid0low10
creatine0low10
lactic acid0low70
nitrous oxide0low20
pyruvic acid0low20
thiamine0medium21
uric acid0low10
aminopropionitrile0low10
3-nitropropionic acid0low10
homovanillic acid0low20
bromazepam0low10
bupivacaine0low10
carbamazepine0low10
clofibrate0low10
clofibric acid0low10
valproic acid0low10
fentanyl0low20
iofetamine0low10
isoflurane0low10
midazolam0low10
piracetam0low10
propofol0low20
mitomycin0low10
prednisone0low30
aspartic acid0low10
galactose0low10
tyrosine0low10
leucine0low20
methionine0low20
arginine0low10
methylprednisolone0medium11
thiamine pyrophosphate0medium11
d-alpha tocopherol0medium11
gadolinium0low10
zalcitabine0low10
4-methoxyamphetamine0low10
zidovudine0low10
alfentanil0low10
n-acetylaspartic acid0low10
etofibrate0low10
valerates0low10
iodofiltic acid0low10
2-ethylhydracrylic acid0low10
3-nitrotyrosine0low10
n-acetylneuraminic acid0low10
riboflavin0medium11
sodium bicarbonate0low10
phenyl-n-tert-butylnitrone0low10
etomidate0low10
3-methylglutaconic acid0low10
thiopental0low10
myelin basic protein0low10
vitamin k semiquinone radical0medium11
vitamin d 20low10
coenzyme q100medium161
levetiracetam0low10
fumarates0low10
phosphorus0low10
selenium0low10
i(3)so3-galactosylceramide0low10
gadolinium dtpa0low10
technetium tc 99m exametazime0low10
cytochrome c-t0medium11
glucagon0low10
c-peptide0low20
ubiquinone0medium231
glycolipids0low10
ascorbic acid0medium11
cyclosporine0low10
flavin mononucleotide0medium11
levoleucovorin0low20
deoxyguanosine0low10
guanine0low10
hypoxanthine0low10
folic acid0low60
8-hydroxy-2'-deoxyguanosine0low10
2',3'-dideoxyguanosine0low10
5-methyltetrahydrofolate0low20
eye0low40
phosphorus radioisotopes0low10

Protein Targets (600)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Protein skinhead-10101
Monocarboxylate transporter 20202
Solute carrier family 22 member 200303
Solute carrier family 22 member 60303
glp-1 receptor, partial2002
TDP1 protein140014
geminin140014
acetylcholinesterase6006
thioredoxin reductase7007
RAR-related orphan receptor gamma100010
GLI family zinc finger 38008
AR protein140014
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)4004
progesterone receptor7007
glucocorticoid receptor [Homo sapiens]110011
retinoic acid nuclear receptor alpha variant 1150015
retinoid X nuclear receptor alpha7007
estrogen-related nuclear receptor alpha150015
estrogen nuclear receptor alpha180018
vitamin D (1,25- dihydroxyvitamin D3) receptor8008
euchromatic histone-lysine N-methyltransferase 2170017
aryl hydrocarbon receptor3003
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a8008
thyrotropin-releasing hormone receptor2002
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a4004
v-jun sarcoma virus 17 oncogene homolog (avian)5005
Histone H2A.x3003
Bloom syndrome protein isoform 15005
hemoglobin subunit beta1001
chromobox protein homolog 19009
heat shock protein beta-15005
DNA polymerase iota isoform a (long)6006
muscarinic acetylcholine receptor M16006
lamin isoform A-delta10100010
Voltage-dependent calcium channel gamma-2 subunit3003
Cellular tumor antigen p53120012
Delta-aminolevulinic acid dehydratase0101
Glutamate receptor 23003
Isocitrate lyase 10101
Isocitrate lyase0101
TAR DNA-binding protein 432002
Isocitrate lyase0101
Chain A, Putative fructose-1,6-bisphosphate aldolase3003
Chain A, JmjC domain-containing histone demethylation protein 3A2002
phosphopantetheinyl transferase5005
bromodomain adjacent to zinc finger domain 2B2002
pyruvate kinase PKM isoform a2002
Glycoprotein hormones alpha chain1001
Guanine nucleotide-binding protein G2002
Tubulin--tyrosine ligase0202
5-hydroxytryptamine receptor 2C0112
5-hydroxytryptamine receptor 2A0112
5-hydroxytryptamine receptor 1A0112
5-hydroxytryptamine receptor 1B0112
5-hydroxytryptamine receptor 1D0112
5-hydroxytryptamine receptor 1F0112
5-hydroxytryptamine receptor 2B0112
5-hydroxytryptamine receptor 60011
Sodium-dependent serotonin transporter0011
Sodium-dependent serotonin transporter0101
5-hydroxytryptamine receptor 7 0011
5-hydroxytryptamine receptor 5A0011
5-hydroxytryptamine receptor 5B0011
5-hydroxytryptamine receptor 3A0011
5-hydroxytryptamine receptor 4 0011
5-hydroxytryptamine receptor 3B0011
Chain A, Avidin0022
Chain A, Avidin0022
Chain B, Avidin0022
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE8008
Chain A, MTA/SAH nucleosidase0101
Chain A, Ribosome-inactivating protein alpha-trichosanthin0011
Chain A, Ricin A chain0011
Chain A, Ribosome-inactivating protein 30011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
nuclear receptor subfamily 1, group I, member 37007
cytochrome P450 family 3 subfamily A polypeptide 4110011
pregnane X nuclear receptor9009
nuclear factor erythroid 2-related factor 2 isoform 28008
importin subunit beta-1 isoform 13003
snurportin-13003
tumor susceptibility gene 101 protein1001
GTP-binding nuclear protein Ran isoform 12002
Bile salt export pump016016
Cyclin-dependent kinase 10101
Heat shock protein HSP 90-beta0101
Xanthine dehydrogenase/oxidase0101
Protein mono-ADP-ribosyltransferase PARP150101
Leucine-rich repeat serine/threonine-protein kinase 20202
ATPase family AAA domain-containing protein 53003
Ataxin-24004
ATP-dependent translocase ABCB10303
Mu-type opioid receptor0516
Kappa-type opioid receptor0303
Mu-type opioid receptor0303
Sigma non-opioid intracellular receptor 10404
ATAD5 protein, partial3003
Lysyl oxidase homolog 20101
arylsulfatase A5005
Protein-lysine 6-oxidase0101
Protein-lysine 6-oxidase0101
Lysyl oxidase homolog 20101
Lysyl oxidase homolog 30101
Lysyl oxidase homolog 40101
Lysyl oxidase homolog 20101
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
NFKB1 protein, partial3003
GLS protein4004
thyroid stimulating hormone receptor7007
alpha-galactosidase2002
cytochrome P450 2C19 precursor3003
flap endonuclease 13003
lethal factor (plasmid)5005
Cytochrome P450 3A40102
Nitric oxide synthase, endothelial0002
Nitric oxide synthase, brain0001
Nitric oxide synthase, brain 0001
Nitric oxide synthase, inducible0001
Nitric oxide synthase, inducible0013
Cationic amino acid transporter 30101
ATP-dependent phosphofructokinase8008
Chain A, Hyaluronidase, phage associated0101
thioredoxin glutathione reductase4004
IDH14004
thyroid hormone receptor beta isoform 26006
nuclear factor erythroid 2-related factor 2 isoform 16006
lethal(3)malignant brain tumor-like protein 1 isoform I1001
Polyphenol oxidase 20102
Pancreatic alpha-amylase0202
Albumin0101
Urease0101
Prolyl 4-hydroxylase subunit alpha-10001
Tyrosinase0101
Alpha-2B adrenergic receptor0011
Spike glycoprotein6006
Hyaluronate lyase0101
Prolyl hydroxylase EGLN20001
Egl nine homolog 10001
Prolyl hydroxylase EGLN30001
Hypoxia-inducible factor 1-alpha inhibitor0001
Solute carrier family 23 member 10101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE6006
Chain A, Ferritin light chain6006
aldehyde dehydrogenase 1 family, member A16006
Metabotropic glutamate receptor 60011
Excitatory amino acid transporter 40101
Glutamate transporter homolog0011
Carbonic anhydrase 10305
Carbonic anhydrase 20305
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase0101
5-hydroxytryptamine receptor 1D0001
Glutamate receptor ionotropic, NMDA 1 0102
Excitatory amino acid transporter 10101
Excitatory amino acid transporter 20101
Excitatory amino acid transporter 30101
Glutamate receptor ionotropic, NMDA 2A 0102
Glutamate receptor ionotropic, NMDA 2B0102
Glutamate receptor ionotropic, NMDA 2C0102
Metabotropic glutamate receptor 10011
Metabotropic glutamate receptor 20011
Carbonic anhydrase-like protein, putative0002
Glutamate receptor ionotropic, NMDA 2D0102
Glutamate receptor ionotropic, NMDA 3B0102
Carbonic anhydrase 40001
Glutamate receptor ionotropic, NMDA 3A0102
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 20011
Potassium channel subfamily K member 90101
Chain A, Beta-lactamase6006
USP1 protein, partial8008
thyroid hormone receptor beta isoform a5005
mitogen-activated protein kinase 13003
Vpr1001
ATP-binding cassette sub-family C member 30808
Multidrug resistance-associated protein 40809
Bile salt export pump0202
Albumin0011
Major prion protein0011
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Cytochrome P450 2C9 0101
UDP-glucuronosyltransferase 2B70205
Cytochrome P450 2B60011
Sodium channel protein type 4 subunit alpha0102
Cytochrome P450 2J20101
Potassium voltage-gated channel subfamily H member 20202
Sodium channel protein type 9 subunit alpha0202
Frizzled-80011
Canalicular multispecific organic anion transporter 10808
P2X purinoceptor 40101
Solute carrier family 22 member 50001
Solute carrier family 22 member 50001
Solute carrier family 22 member 160001
Solute carrier family 22 member 210001
Solute carrier family 22 member 50001
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein0011
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Choline-binding protein0011
Solute carrier family 22 member 10102
Solute carrier family 22 member 20001
Solute carrier family 22 member 1 0305
Solute carrier family 22 member 20101
Neuronal acetylcholine receptor subunit alpha-30101
Neuronal acetylcholine receptor subunit alpha-40101
Neuronal acetylcholine receptor subunit alpha-20101
Neuronal acetylcholine receptor subunit beta-20101
Neuronal acetylcholine receptor subunit beta-30101
Neuronal acetylcholine receptor subunit beta-40101
Neuronal acetylcholine receptor subunit alpha-50101
Acetylcholinesterase0101
Sodium- and chloride-dependent creatine transporter 10101
Choline O-acetyltransferase 0001
Neuronal acetylcholine receptor subunit alpha-60101
Neuronal acetylcholine receptor subunit alpha-90101
Neuronal acetylcholine receptor subunit alpha-70112
Solute carrier family 22 member 10203
High affinity choline transporter 10101
Neuronal acetylcholine receptor subunit alpha-100101
Solute carrier family 22 member 20203
Fumarate hydratase3003
GALC protein2002
regulator of G-protein signaling 42002
EWS/FLI fusion protein5005
polyprotein3003
thyroid stimulating hormone receptor3003
activating transcription factor 66006
peripheral myelin protein 22 isoform 11001
potassium voltage-gated channel subfamily H member 2 isoform d4004
cytochrome P450 3A4 isoform 15005
M-phase phosphoprotein 83003
Gamma-aminobutyric acid receptor subunit pi5319
5-hydroxytryptamine receptor 40213
Fatty acid-binding protein, liver0112
Muscarinic acetylcholine receptor M10011
Muscarinic acetylcholine receptor M30011
Muscarinic acetylcholine receptor M40011
Muscarinic acetylcholine receptor M50011
Muscarinic acetylcholine receptor M20011
Gamma-aminobutyric acid receptor subunit beta-15319
Gamma-aminobutyric acid receptor subunit delta5319
Gamma-aminobutyric acid receptor subunit gamma-25319
Gamma-aminobutyric acid receptor subunit alpha-55319
Gamma-aminobutyric acid receptor subunit alpha-35319
Peroxisome proliferator-activated receptor alpha0022
Gamma-aminobutyric acid receptor subunit gamma-15319
Gamma-aminobutyric acid receptor subunit alpha-25319
Gamma-aminobutyric acid receptor subunit alpha-45319
Gamma-aminobutyric acid receptor subunit gamma-35319
Gamma-aminobutyric acid receptor subunit alpha-65319
Peroxisome proliferator-activated receptor gamma0022
Peroxisome proliferator-activated receptor gamma0022
Gamma-aminobutyric acid receptor subunit alpha-15319
Gamma-aminobutyric acid receptor subunit beta-35319
Gamma-aminobutyric acid receptor subunit beta-25319
Inositol monophosphatase 12002
Peroxisome proliferator-activated receptor alpha0022
GABA theta subunit5319
Gamma-aminobutyric acid receptor subunit epsilon5319
Microtubule-associated protein tau3003
peroxisome proliferator-activated receptor delta3003
cytochrome P450 2D6 isoform 11001
Glutamate receptor ionotropic, NMDA 2D0011
Glutamate receptor ionotropic, NMDA 3B0011
Fatty acid-binding protein, intestinal0101
Peroxisome proliferator-activated receptor delta0011
Glutamate receptor ionotropic, NMDA 10011
Glutamate receptor ionotropic, NMDA 2A0011
Glutamate receptor ionotropic, NMDA 2B0011
Glutamate receptor ionotropic, NMDA 2C0011
Glutamate receptor ionotropic, NMDA 3A0011
peripheral myelin protein 224004
Sodium- and chloride-dependent creatine transporter 10101
Proton-coupled amino acid transporter 10203
Rap guanine nucleotide exchange factor 33003
Glutathione S-transferase P0101
Alpha-tocopherol transfer protein0011
67.9K protein3003
Thymidine kinase, cytosolic0305
Deoxycytidine kinase0102
AAA family ATPase 0001
Sterol O-acyltransferase 10101
Acetylcholine receptor subunit alpha0101
Acetylcholine receptor subunit beta0101
Acetylcholine receptor subunit gamma0101
Acetylcholine receptor subunit delta0101
Acetylcholine receptor subunit delta0101
Acetylcholine receptor subunit alpha0101
Acetylcholine receptor subunit gamma0101
Acetylcholine receptor subunit beta0101
Gamma-aminobutyric acid receptor subunit alpha-10224
Cytochrome P450 11B1, mitochondrial0101
Gamma-aminobutyric acid receptor subunit gamma-20224
Cytochrome P450 11B2, mitochondrial0101
Gamma-aminobutyric acid receptor subunit alpha-20022
Gamma-aminobutyric acid receptor subunit beta-20123
Transporter0101
Luciferase2002
Nuclear receptor subfamily 1 group I member 20022
D(2) dopamine receptor0101
Amine oxidase [flavin-containing] A0101
D(4) dopamine receptor0101
Amine oxidase [flavin-containing] B0101
Delta-type opioid receptor0202
Delta-type opioid receptor0202
Kappa-type opioid receptor0101
Histamine H1 receptor0101
Mu-type opioid receptor0213
D(3) dopamine receptor0101
Delta-type opioid receptor0202
Kappa-type opioid receptor0202
Mu-type opioid receptor0101
Sigma non-opioid intracellular receptor 10202
Sigma non-opioid intracellular receptor 10101
Chain A, Dihydrofolate reductase0011
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
Chain A, 2-oxoglutarate Oxygenase1001
acid sphingomyelinase1001
glucocerebrosidase1001
lysosomal alpha-glucosidase preproprotein2002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
DNA polymerase beta1001
Thymidylate synthase0202
Thymidylate synthase0101
Dihydrofolate reductase0011
Aldo-keto reductase family 1 member B10101
Alpha-synuclein1001
Folylpolyglutamate synthase, mitochondrial0001
Solute carrier organic anion transporter family member 1A30102
Folylpolyglutamate synthase, mitochondrial0001
Multidrug resistance associated protein0001
DNA polymerase kappa isoform 12002
histone acetyltransferase KAT2A isoform 15005
Beta-galactosidase0101
Lipopolysaccharide heptosyltransferase 10101
PA-I galactophilic lectin0011
Jacalin0011
Purine nucleoside phosphorylase0202
Hypoxanthine-guanine phosphoribosyltransferase0002
Ricin0101
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase0011
Purine nucleoside phosphorylase 0024
Shiga toxin subunit A0101
Guanine deaminase0102
ClpP1001
Solute carrier family 22 member 80001
Chain A, Purine-nucleoside Phosphorylase0101
Chain C, Xanthine dehydrogenase/oxidase0011
peroxisome proliferator activated receptor gamma5005
atrial natriuretic peptide receptor 1 precursor1001
Neuronal acetylcholine receptor subunit beta-20101
Neuronal acetylcholine receptor subunit alpha-70101
estrogen receptor 2 (ER beta)4004
cytochrome P450 2D63003
cellular tumor antigen p53 isoform a1001
Integrin beta-31001
Integrin alpha-IIb1001
Chain A, AMINOPEPTIDASE0101
Chain A, AMINOPEPTIDASE0101
Chain A, Leucine Aminopeptidase0101
Alkaline phosphatase, tissue-nonspecific isozyme0101
Intestinal-type alkaline phosphatase0101
Large neutral amino acids transporter small subunit 10303
Phospholipase A-2-activating protein0101
chaperonin-containing TCP-1 beta subunit homolog1001
Synaptic vesicle glycoprotein 2A0202
Chain A, Methionyl-tRNA synthetase0011
Chain A, Methionyl-tRNA synthetase0011
Chain A, Aminopeptidase0101
Chain A, Methionine aminopeptidase0101
S-ribosylhomocysteine lyase0101
Adenylate cyclase type 50001
S-adenosylmethionine synthase isoform type-10001
S-adenosylmethionine synthase isoform type-20001
Fatty acid synthase0101
hypoxia-inducible factor 1 alpha subunit3003
PPM1D protein1001
nonstructural protein 11001
G2002
nuclear receptor subfamily 1, group I, member 23003
muscleblind-like protein 1 isoform 11001
Interferon beta2002
HLA class I histocompatibility antigen, B alpha chain 2002
Glucocorticoid receptor0415
Glycine receptor subunit alpha-10404
Androgen receptor0202
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Inositol hexakisphosphate kinase 12002
Nuclear receptor subfamily 1 group I member 20011
cytochrome P450 2C9, partial2002
ATP-dependent translocase ABCB10101
Translocator protein0101
UDP-glucuronosyltransferase 1-60102
ATP-dependent translocase ABCB10101
UDP-glucuronosyltransferase 1A1 0101
UDP-glucuronosyltransferase 1A40101
UDP-glucuronosyltransferase 2B10 0101
caspase 7, apoptosis-related cysteine protease3003
farnesoid X nuclear receptor6006
caspase-33003
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
Indoleamine 2,3-dioxygenase 10101
transcriptional regulator ERG isoform 31001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
Rap guanine nucleotide exchange factor 41001
Sialidase-40101
Sialidase-10101
Sialidase-30101
Sialidase-20101
Retinoid isomerohydrolase 0101
Retinoid isomerohydrolase 0101
Retinoid isomerohydrolase0101
Hsf1 protein0012
pregnane X receptor2002
vitamin D3 receptor isoform VDRA2002
nuclear receptor ROR-gamma isoform 11001
Nuclear receptor ROR-gamma2002
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
D(1A) dopamine receptor1001
Fatty-acid amide hydrolase 10101
UDP-glucuronosyltransferase 1A90002
Aldo-keto reductase family 1 member B10303
Gamma-aminobutyric acid receptor subunit alpha-10002
Gamma-aminobutyric acid receptor subunit beta-10002
Gamma-aminobutyric acid receptor subunit alpha-20002
Gamma-aminobutyric acid receptor subunit alpha-30002
Polyunsaturated fatty acid lipoxygenase ALOX150101
Gamma-aminobutyric acid receptor subunit beta-10011
Gamma-aminobutyric acid receptor subunit alpha-40002
Gamma-aminobutyric acid receptor subunit gamma-20002
Prostaglandin G/H synthase 10101
Sodium-dependent noradrenaline transporter 0202
Sodium- and chloride-dependent GABA transporter 10202
5-hydroxytryptamine receptor 2C0202
Gamma-aminobutyric acid receptor subunit beta-30112
Gamma-aminobutyric acid receptor subunit alpha-50011
Sodium- and chloride-dependent GABA transporter 20202
Sodium- and chloride-dependent GABA transporter 30202
Gamma-aminobutyric acid receptor subunit alpha-30011
5-hydroxytryptamine receptor 2B0202
Sodium- and chloride-dependent betaine transporter0202
Gamma-aminobutyric acid receptor subunit alpha-40011
Fatty-acid amide hydrolase 10202
Gamma-aminobutyric acid receptor subunit alpha-60011
UDP-glucuronosyltransferase 1A80001
Monocarboxylate transporter 40001
Monocarboxylate transporter 20001
Monocarboxylate transporter 10001
C-terminal-binding protein 20101
Prolyl 4-hydroxylase0101
Solute carrier organic anion transporter family member 2A10101
Alpha-ketoglutarate-dependent dioxygenase FTO0101
Chain A, 6,7-Dimethyl-8-ribityllumazine Synthase0011
Chain B, 6,7-Dimethyl-8-ribityllumazine Synthase0011
Chain A, Breast cancer type 1 susceptibility protein1001
Chain H, Immunoglobulin Igg1 Heavy chain0011
Chain L, Immunoglobulin Igg1 Lambda Light Chain0011
Chain A, DODECIN0011
Chain A, DODECIN0011
Chain C, DODECIN0011
Chain E, DODECIN0011
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
15-lipoxygenase, partial1001
SMAD family member 22002
SMAD family member 32002
NPYLR7B0011
tumor necrosis factor1001
nuclear factor NF-kappa-B p105 subunit isoform 11001
caspase-1 isoform alpha precursor1001
Riboflavin-binding protein0112
60 kDa chaperonin0202
60 kDa heat shock protein, mitochondrial0202
Caspase-71001
10 kDa heat shock protein, mitochondrial0202
Thiosulfate sulfurtransferase0202
60 kDa chaperonin 0202
10 kDa chaperonin 0202
Carbonic anhydrase 0101
Carbonic anhydrase 40102
Carbonic anhydrase 5A, mitochondrial0102
Carbonic anhydrase0102
Carbonic anhydrase 90102
Carbonic anhydrase 0101
Carbonic anhydrase 5B, mitochondrial0102
Chain A, ykoF0011
Chain B, ykoF0011
Chain A, ThiT0011
Thiamine transporter ThiT0011
Carbonic anhydrase 60102
Transketolase0011
Thiamine-binding periplasmic protein0011
Acetylcholinesterase0101
1-deoxy-D-xylulose-5-phosphate synthase0011
1-deoxy-D-xylulose-5-phosphate synthase0011
Chain A, CHORISMATE MUTASE0101
Chain A, TYROSYL-tRNA SYNTHETASE0011
Carbonic anhydrase 120001
Plasma kallikrein0001
Carbonic anhydrase 30001
Adenosine receptor A10001
Adenosine receptor A2a0001
Carbonic anhydrase 70001
Carbonic anhydrase0001
SLC16A10 protein0001
Carbonic anhydrase 0001
Carbonic anhydrase0001
Carbonic anhydrase0001
Carbonic anhydrase 0001
Monocarboxylate transporter 100001
Carbonic anhydrase 150001
Taste receptor type 2 member 140001
Carbonic anhydrase 140001
Chain A, Glycogen phosphorylase, liver form0011
Chain A, glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Solute carrier family 22 member 60002
Solute carrier family 22 member 80102
Solute carrier family 2, facilitated glucose transporter member 90112
Carbonic anhydrase0101
Cocaine esterase0101
Histone deacetylase 30202
Cytochrome P450 2A60101
Tissue factor0101
Aldo-keto reductase family 1 member A10101
Liver carboxylesterase 10101
Aldo-keto reductase family 1 member A10101
Histone deacetylase 40202
Histone deacetylase 10202
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member B70101
Histone deacetylase 70202
Histone deacetylase 20202
Polyamine deacetylase HDAC100202
Histone deacetylase 11 0202
Histone deacetylase 80202
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
Histone deacetylase 60202
Histone deacetylase 90202
Histone deacetylase 50202
eyes absent homolog 2 isoform a1001
Vitamin D3 receptor0001
Albumin0022
C-X-C chemokine receptor type 40011
Solute carrier family 22 member 70002
Reverse transcriptase/RNaseH 0239
Caspase-71001
caspase-31001
serine/threonine-protein kinase mTOR isoform 11001
serine/threonine-protein kinase PLK11001
tyrosine-protein kinase Yes1001
Ectonucleoside triphosphate diphosphohydrolase 10001
Solute carrier family 22 member 60001
Protein kinase C beta type0101
DNA polymerase beta0101
Thymidine kinase, cytosolic 0001
Thymidylate kinase0101
Protein kinase C epsilon type0101
Thymidine kinase 0102
Protease 0112
Solute carrier family 22 member 110001
Thymidine kinase0102
Solute carrier family 22 member 70001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]