ascorbic-acid and Urticaria

In 20 volunteers with normal skin, itching and concomitant erythemas and wheals were produced by mechanical stimulation with a magnetic oscillation system. In a placebo-controlled, randomized double-blind study with twice cross-over, a calcium-vitamin-D-combination as single dose ampoules for peroral application was tested. A significant decrease (p less than 0,001) of the areas of erythema and wheal and itching in treated persons, compared with non-treated and placebo-treated volunteers serving for controls, is showing the antiallergic effectiveness of the tested preparation.

Topics: Adult; Ascorbic Acid; Calcium; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Ergocalciferols; Erythema; Female; Gluconates; Humans; Male; Middle Aged; Physical Stimulation; Pruritus; Urticaria

Pressure urticaria as a subform of physical urticaria is rare and treatment is often difficult. Established therapeutic regimes include antihistamines (generally exceeding approved dosages in order to achieve a therapeutic benefit) or antihistamines combined with montelukast. Complete relief of symptoms is difficult.. We used dapsone as an early therapeutic alternative in the event of treatment failure and established a standardized therapeutic regime at our clinic. We surveyed 31 patients retrospectively who had received dapsone between 2003-2009.. In 74 % of patients in whom symptoms persisted despite established therapies, the results of treatment with dapsone were good or very good. Longer-term pressure urticaria and the co-existence of a chronic spontaneous urticaria were associated with a smaller benefit (p<0.05). No significant effects were found related to age, gender, duration of therapy, side-effects, or Met-Hb elevation (a tendency toward a decreased benefit was associated with middle-age, male sex, shorter duration of therapy, observed side-effects, and Met-Hb elevation).. Therapy is well tolerated and results in a good therapeutic benefit which lasts after termination of therapy. With adequate monitoring, the use of dapsone in patients with pressure urticaria has such a good risk-benefit ratio that we support early treatment initiation.

Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Ascorbic Acid; Chronic Disease; Dapsone; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance; Drug Therapy, Combination; Female; Humans; Male; Methemoglobin; Middle Aged; Pressure; Retrospective Studies; Urticaria

The newly-generated lipid mediators include products of arachidonate metabolism, prostaglandins and leukotrienes. In this study, serum lipids and fatty acids, including arachidonic acid (C20:4) were examined in 12 normal subjects (6 males and 6 females) and 23 subjects with chronic urticaria (6 males and 17 females), including 17 who made an excellent or good recovery (4 males and 13 females). The results indicated a relationship between chronic urticaria and serum lipids and fatty acids. The omega 6 (n-6) and omega 3 (n-3) series of polyunsaturated fatty acids and lipid peroxidation were suggested that may be one of the mediators in chronic urticaria. Pantethine, glutathione and ascorbic acid were effective in controlling chronic urticaria.

Topics: Adult; Ascorbic Acid; Chronic Disease; Fatty Acids; Female; Glutathione; Humans; Lipids; Male; Middle Aged; Pantetheine; Urticaria

Topics: Anaphylaxis; Ascorbic Acid; Drug Hypersensitivity; Humans; Iatrogenic Disease; Male; Medication Errors; Middle Aged; Penicillin G; Skin Tests; Urticaria

Topics: Acne Vulgaris; Adolescent; Amino Acids; Ascorbic Acid; Dermatitis; Dermatitis, Contact; Dermatology; Drug Eruptions; Eczema; Erythema; Glutamates; Melanosis; Neurodermatitis; Pantothenic Acid; Polyarteritis Nodosa; Psoriasis; Tablets; Tiopronin; Toxicology; Urticaria

Topics: Anti-Allergic Agents; Antineoplastic Agents; Ascorbic Acid; Flavonoids; Histamine H1 Antagonists; Humans; Skin Diseases; Urticaria; Vitamins