Page last updated: 2024-08-05 14:23:34
mutagen
An agent that increases the frequency of mutations above the normal background level, usually by interacting directly with DNA and causing it damage, including base substitution.
ChEBI ID: 25435
Members (83)
| Member | Definition | Class |
|---|---|---|
| (2e)-decenal | A dec-2-enal in which the olefinic double bond has E configuration. | (2E)-dec-2-enal |
| 1-amino-2-naphthol-4-sulfonic acid | 4-amino-3-hydroxynaphthalene-1-sulfonic acid | |
| 1-bromo-2-chloroethane | A haloalkane that is bromoethane substituted by chlorine at position 2. | 1-bromo-2-chloroethane |
| 1-methylphenanthrene | A member of the class of phenanthrenes that is phenanthrene substituted by a methyl group at position 1. | 1-methylphenanthrene |
| 1,2,5,6-dibenzanthracene | dibenz[a,h]anthracene | |
| 1,2,7,8-diepoxyoctane | 1,2:7,8-diepoxyoctane | |
| 1,3-butadiene | A butadiene with unsaturation at positions 1 and 3. | buta-1,3-diene |
| 1,n(6)-ethenoadenine | 1H-imidazo[2,1-i]purine; 3H-imidazo[2,1-i]purine | |
| 2-acetylaminofluorene | The parent of the class of 2-acetamidofluorenes, being an ortho-fused polycyclic arene that consists of 9H-fluorene bearing an acetamido substituent at position 2. It is a carcinogenic and mutagenic derivative of fluorene. | 2-acetamidofluorene |
| 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine | An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish. | PhIP |
| 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline | An imidazoquinoxaline that is 3H-imidazo[4,5-f]quinoxaline substituted at positions 3 and 8 by methyl groups and at position 2 by an amino group. A mutagenic compound found in cooked beef. | MeIQx |
| 2-amino-n(6)-hydroxyadenine | A 2,6-diaminopurine that is the N(6)-hydroxy derivative of 2,6-diamino-3H-purine. | 2-amino-6-hydroxyaminopurine |
| 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine | An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, hydoxyamino, and phenyl groups, respectively. The active metabolite of the dietary carcinogen PhIP. | N-hydroxy-PhIP |
| 2-nitrofluorene | A nitroarene that is fluorene substituted by a nitro group at position 2. | 2-nitrofluorene |
| 2,6-diaminotoluene | A diamine that is toluene in which both of the hydrogens ortho- to the methyl group are replaced by amino groups. | 2,6-diaminotoluene |
| 3,n(4)-ethanocytosine | 3,N(4)-ethenocytosine | |
| 4-methylquinoline | A methylquinoline carrying a methyl substituent at position 4. | 4-methylquinoline |
| 4-nitrobenzyl chloride | A C-nitro compound that is nitrobenzene in which the hydrogen at position 4 is replaced by a chloromethyl group. | p-nitrobenzyl chloride |
| 4-nitrophenylhydrazine | A member of the class of phenylhydrazines that is phenylhydrazine substituted at the 4-position by a nitro group. | 4-nitrophenylhydrazine |
| 5-bromouridine | A uridine having a bromo substituent at the 5-position. | 5-bromouridine |
| 5-fluorouridine | An organofluorine compound that is uridine bearing a fluoro substituent at position 5 on the uracil ring. | 5-fluorouridine |
| 5-formyluracil | A pyrimidone resulting from the formal oxidation of the alcoholic hydroxy group of 5-hydroxymethyluracil to the corresponding aldehyde. It is a major one-electron photooxidation product of thymine in oligodeoxynucleotides. | 5-formyluracil |
| 6-n-hydroxylaminopurine | A member of the class of 6-aminopurinnes that is adenine in which one of the exocyclic amino hydrogens is replaced by a hydroxy group. | N(6)-hydroxyadenine |
| 8-oxodeoxyguanosine triphosphate | A purine 2'-deoxyribonucleoside 5'-triphosphate having 8-oxo-7,8-dihydroguanine as the nucleobase. | 8-oxo-dGTP |
| acetaldehyde | The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke. | acetaldehyde |
| acetoxyacetylaminofluorene | A 2-acetamidofluorene compound in which the parent 2-acetamidofluorene is substituted on nitrogen by an acetoxy group. | N-acetoxy-2-acetamidofluorene |
| acridine half-mustard | A member of the class of aminoacridines that is acridine which is substituted by a methoxy group at position 2, chlorine at position 6, and a {3-[(2-chloroethyl)amino]propyl}amino group at position 9. | acridine half-mustard |
| acrylamide | A member of the class of acrylamides that results from the formal condensation of acrylic acid with ammonia. | acrylamide |
| acrylonitrile | A nitrile that is hydrogen cyanide in which the hydrogen has been replaced by an ethenyl group. | acrylonitrile |
| aminacrine | An aminoacridine that is acridine in which the hydrogen at position 9 is replaced by an amino group. A fluorescent dyd and topical antiseptic agent, it is used (usually as the hydrochloride salt) in eye drops for the treatment of superficial eye infections. | 9-aminoacridine |
| aminopterin | 4-aminofolic acid | |
| aristolochic acid c | An aristolochic acid that is phenanthrene-1-carboxylic acid substituted by a methylenedioxy group at the 3,4 positions, by an hydroxy group at position 6, and by a nitro group at position 10. | aristolochic acid C |
| aristolochic acid i | An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic. | aristolochic acid A |
| aristolochic acid ii | An aristolochic acid that is phenanthrene-1-carboxylic acid substituted by a methylenedioxy group at the 3,4 positions and by a nitro group at position 10. | aristolochic acid B |
| benzo(b)fluoranthene | An ortho- and peri-fused polycyclic arene that consists of a benzene ring fused with a acephenanthrylene ring. | benzo[b]fluoranthene |
| benzo(e)pyrene | An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings. It is listed as a Group 3 carcinogen by the IARC. | benzo[e]pyrene |
| bromouracil | A pyrimidine having keto groups at the 2- and 4-positions and a bromo group at the 5-position. Used mainly as an experimental mutagen. | 5-bromouracil |
| c.i. solvent yellow 56 | An azobenzene that is N,N-diethylaniline substituted at position 4 by a phenylazo group. | Solvent yellow 56 |
| caffeine | A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee. | caffeine |
| cisplatin | A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups). | cisplatin; transplatin |
| colchicine | A colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions. | (S)-colchicine |
| dactinomycin | actinomycin D | |
| demethylbellidifolin | A member of the class of xanthones that is xanthone which is substituted by hydroxy groups at positions 1, 3, 5, and 8. A natural product found particularly in Iris nigricans and Gentiana campestris. | bellidin |
| dibenzo(a,l)pyrene | dibenzo[a,l]pyrene | |
| diepoxybutane | diepoxybutane | |
| diethyl sulfate | The diethyl ester of sulfuric acid. | diethyl sulfate |
| diethylnitrosamine | A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom. | N-nitrosodiethylamine |
| dimethylmyleran | A methanesulfonate ester that is hexane-2,5-diol in which the hydrogens of the hydroxy groups are replaced by methanesulfonyl groups. | dimethylmyleran |
| dimethylnitrosamine | N-nitrosodimethylamine | |
| ethyl methanesulfonate | A methanesulfonate ester resulting from the formal condensation of methanesulfonic acid with ethanol. | ethyl methanesulfonate |
| ethylene dibromide | A bromoalkane that is ethane carrying bromo substituents at positions 1 and 2. It is produced by marine algae. | 1,2-dibromoethane |
| ethylene dichloride | A member of the class of chloroethanes substituted by two chloro groups at positions 1 and 2. | 1,2-dichloroethane |
| ethylene oxide | A saturated organic heteromonocyclic parent that is a three-membered heterocycle of two carbon atoms and one oxygen atom. | oxirane |
| ethylenimine quinone | A member of the class of 1,4-benzoquinones that is p-benzoquinone in which the hydrogens at positions 2 and 5 are replaced by aziridin-1-yl groups. | 2,5-bis(aziridin-1-yl)-1,4-benzoquinone |
| ethylnitrosourea | A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by ethyl and nitroso groups. | N-ethyl-N-nitrosourea |
| fagaronine | fagaronine | |
| ferric nitrilotriacetate | An iron chelate resulting from the combination of equimolar amounts of iron(3+) and nitrilotriacetate(3-). | iron(III) nitrilotriacetate |
| hempa | hexamethylphosphoric triamide | |
| hesperidin | A disaccharide derivative that consists of hesperetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage. | hesperidin |
| hycanthone | A thioxanthen-9-one compound having a hydroxymethyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. It was formerly used (particularly as the monomethanesulfonic acid salt) as a schistosomicide for individual or mass treatement of infection with Schistosoma haematobium and S. mansoni, but due to its toxicity and concern about possible carcinogenicity, it has been replaced by other drugs such as praziquantel. | hycanthone |
| hycanthone methanesulfonate | A methanesulfonate salt resulting from the reaction of equimolar amounts of hycanthone and methanesulfonic acid. It was formerly used as a schistosomicide for individual or mass treatement of infection with Schistosoma haematobium and S. mansoni, but due to its toxicity and concern about possible carcinogenicity, it has been replaced by other drugs such as praziquantel. | hycanthone mesylate |
| lucanthone | A thioxanthen-9-one compound having a methyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. Formerly used for the treatment of schistosomiasis. It is a prodrug, being metabolised to hycanthone. | lucanthone |
| methoxyacetic acid | A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by a methoxy group. | methoxyacetic acid |
| methyl chloride | A one-carbon compound that is methane in which one of the hydrogens is replaced by a chloro group. | chloromethane |
| methyl methanesulfonate | A methanesulfonate ester resulting from the formal condensation of methanesulfonic acid with methanol. | methyl methanesulfonate |
| methylnitrosourea | A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by methyl and nitroso groups. | N-methyl-N-nitrosourea |
| myosmine | A member of the class of pyridines that is pyridine substituted by a 3,4-dihydro-2H-pyrrol-5-yl group at position 3. It is an alkaloid found in tobacco plants and exhibits genotoxic effects. | myosmine |
| n-nitrosomorpholine | A nitrosamine that is morpholine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. A carcinogen and mutagen, it is found in snuff tobacco. | N-nitrosomorpholine |
| n-nitrosopiperidine | A nitrosamine that is piperidine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. One of the many carcinogens detected in cigarette smoke, it is found in meat, cheese and spices that have been treated with the preservative sodium nitrite. | N-nitrosopiperidine |
| nitrosocarbaryl | A nitroso compound that is carbaryl in which the amino hydrogen is substituted by a nitroso group. | nitrosocarbaryl |
| o-(6)-methylguanine | A methylguanine in which the methyl group is positioned on the oxygen at position 6. Formed in DNA by alkylation of the oxygen atom of guanine, most often by N-nitroso compounds and sometimes due to methylation by other compounds such as endogenous S-adenosylmethionine, it base-pairs to thymine rather than cytidine, causing a G:C to A:T transition in DNA. | 6-O-methylguanine |
| ozone | An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs. | ozone |
| patulin | A furopyran and lactone that is (2H-pyran-3(6H)-ylidene)acetic acid which is substituted by hydroxy groups at positions 2 and 4 and in which the hydroxy group at position 4 has condensed with the carboxy group to give the corresponding bicyclic lactone. A mycotoxin produced by several species of Aspergillus and Penicillium, it has antibiotic properties but has been shown to be carcinogenic and mutagenic. | patulin |
| phenanthridone | A member of the class of phenanthridines that is phenanthridine with an oxo substituent at position 6. A poly(ADP-ribose) polymerase (PARP) inhibitor, it has been shown to exhibit immunosuppressive activity. | phenanthridone |
| riddelliine | A macrodiolide that is 13,19-didehydrosenecionan bearing two additional hydroxy substituents at positions 12 and 18 as well as two additional oxo groups at positions 11 and 16. | riddelliine |
| riddelliine n-oxide | A pyrrolizine alkaloid that is 13,19-didehydrosenecionane bearing two additional hydroxy substituents at positions 12 and 18, two additional oxo groups at positions 11 and 16 and an N-oxido substituent. | riddelliine N-oxide |
| sodium azide | The sodium salt of hydrogen azide (hydrazoic acid). | sodium azide |
| sodium bisulfite | An inorganic sodium salt having hydrogensulfite as the counterion. | sodium hydrogensulfite |
| sodium fluoride | A metal fluoride salt with a Na(+) counterion. | sodium fluoride |
| spiroiminodihydantoin | An azaspiro compound that is 1,3,6,8-tetraazaspiro[4.4]non-6-ene which is substituted by oxo groups at positions 2, 4, and 9. Both enantiomers are highly mutagenic products resulting from the oxidation of guanine and 8-oxo-7,8-dihydroguanine in DNA by reactive oxygen species. | spiroiminodihydantoin |
| styrene | A vinylarene that is benzene carrying a vinyl group. It has been isolated from the benzoin resin produced by Styrax species. | styrene |
| urethane | A carbamate ester obtained by the formal condensation of ethanol with carbamic acid. It has been found in alcoholic beverages. | urethane |
| vinylidene chloride | A member of the class of chloroethenes that is ethene in which both of the hydrogens attached to one of the carbons are replaced by chlorines. | 1,1-dichloroethene |
Research
Studies (129,237)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 48,693 (37.68) | 18.7374 |
| 1990's | 22,000 (17.02) | 18.2507 |
| 2000's | 24,188 (18.72) | 29.6817 |
| 2010's | 24,836 (19.22) | 24.3611 |
| 2020's | 9,520 (7.37) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 5,048 (3.57%) | 5.53% |
| Reviews | 7,565 (5.35%) | 6.00% |
| Case Studies | 3,605 (2.55%) | 4.05% |
| Observational | 144 (0.10%) | 0.25% |
| Other | 125,131 (88.44%) | 84.16% |
Protein Targets (336)
Potency Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 11.1904 | 1 | 4 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 17.7314 | 1 | 3 |
| 67.9K protein | Vaccinia virus | Potency | 10.7290 | 2 | 11 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 44.8369 | 4 | 9 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 26.0641 | 2 | 22 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 28.5888 | 1 | 20 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 40.0748 | 2 | 2 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| Amyloid-beta precursor protein | Homo sapiens (human) | Potency | 20.5962 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 18.1545 | 12 | 122 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 16.3495 | 3 | 32 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 15.1727 | 5 | 8 |
| Ataxin-2 | Homo sapiens (human) | Potency | 19.8277 | 1 | 12 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 18.5636 | 2 | 5 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 15.9320 | 2 | 18 |
| atrial natriuretic peptide receptor 1 precursor | Homo sapiens (human) | Potency | 4.7755 | 1 | 1 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 1.8493 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 23.0044 | 3 | 6 |
| BRCA1 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 34.4666 | 1 | 3 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 29.8910 | 1 | 6 |
| caspase-1 isoform alpha precursor | Homo sapiens (human) | Potency | 29.7263 | 1 | 4 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 33.3484 | 1 | 4 |
| caspase-3 | Homo sapiens (human) | Potency | 29.8910 | 1 | 6 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 33.3484 | 1 | 4 |
| Caspase-7 | Homo sapiens (human) | Potency | 22.1060 | 1 | 2 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 31.2868 | 3 | 36 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 11.9651 | 2 | 5 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 28.0516 | 1 | 4 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 11.4821 | 2 | 4 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 5.0119 | 1 | 1 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 10.8064 | 1 | 3 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 37.2114 | 2 | 4 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 24.5035 | 2 | 11 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 67.8334 | 1 | 2 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 26.3106 | 3 | 12 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 14.6984 | 1 | 2 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 21.2839 | 1 | 4 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 24.5035 | 2 | 11 |
| chaperonin GroEL | Methanococcus maripaludis S2 | Potency | 79.4328 | 1 | 1 |
| chaperonin-containing TCP-1 beta subunit homolog | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 55.8711 | 2 | 10 |
| CREB-binding protein | Homo sapiens (human) | Potency | 5.0119 | 2 | 2 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 11.0406 | 1 | 3 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 3.1623 | 1 | 2 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 4.3649 | 1 | 1 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 15.2056 | 1 | 3 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 13.6208 | 2 | 17 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 15.5921 | 2 | 3 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 16.4392 | 1 | 12 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3F isoform a | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | Potency | 2.2387 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 46.6500 | 1 | 3 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| DNA polymerase III, partial | Bacillus subtilis | Potency | 18.8876 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 68.9382 | 1 | 6 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 40.8637 | 1 | 8 |
| endonuclease IV | Escherichia coli | Potency | 1.9622 | 1 | 2 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 21.6336 | 12 | 147 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 40.0984 | 3 | 20 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 22.4223 | 8 | 106 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 10.4271 | 1 | 11 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 28.5488 | 5 | 32 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 26.5019 | 3 | 7 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 12.5613 | 1 | 2 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 13.4196 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 13.4196 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 13.4196 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 13.4196 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 13.4196 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 13.4196 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 13.4196 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 13.4196 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 13.4196 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 13.4196 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 13.4196 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 13.4196 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 13.4196 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 13.4196 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 13.4196 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 13.4196 | 1 | 9 |
| geminin | Homo sapiens (human) | Potency | 8.3287 | 4 | 16 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 13.5303 | 3 | 34 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 19.7020 | 1 | 2 |
| GLS protein | Homo sapiens (human) | Potency | 27.3013 | 2 | 6 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 24.1427 | 5 | 43 |
| glucokinase regulatory protein | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 15.5610 | 2 | 14 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1 | Homo sapiens (human) | Potency | 1.9953 | 1 | 1 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 16.5978 | 1 | 2 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 39.3076 | 2 | 14 |
| hemoglobin subunit beta | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| hexokinase-4 isoform 1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 3.1623 | 1 | 6 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 25.9894 | 2 | 10 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 58.4129 | 2 | 13 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 40.5174 | 1 | 3 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 6.0514 | 3 | 4 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 1.9012 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 37.0020 | 2 | 15 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 19.9224 | 3 | 5 |
| IDH1 | Homo sapiens (human) | Potency | 4.4085 | 1 | 3 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 12.9107 | 2 | 8 |
| interleukin 8 | Homo sapiens (human) | Potency | 37.5351 | 1 | 7 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 4.3334 | 2 | 7 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 13.1139 | 1 | 11 |
| lethal(3)malignant brain tumor-like protein 1 isoform I | Homo sapiens (human) | Potency | 7.0795 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 24.9539 | 1 | 9 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 2.6157 | 1 | 2 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 14.6479 | 2 | 10 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 27.2915 | 2 | 5 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 0.3560 | 1 | 3 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 15.4070 | 1 | 3 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 13.8154 | 1 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 19.2864 | 4 | 61 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 6.0511 | 1 | 3 |
| nuclear factor NF-kappa-B p105 subunit isoform 1 | Homo sapiens (human) | Potency | 44.6684 | 1 | 2 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 48.7784 | 2 | 12 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 2.5382 | 1 | 9 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 13.9803 | 2 | 12 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 17.7828 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 20.2491 | 3 | 57 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 38.9735 | 2 | 4 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 3.6829 | 2 | 6 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 76.1884 | 1 | 2 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 24.0192 | 5 | 40 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 23.8855 | 5 | 39 |
| phosphoglycerate kinase | Trypanosoma brucei brucei TREU927 | Potency | 26.8545 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 89.1251 | 1 | 1 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 8.4719 | 1 | 2 |
| polyprotein | Zika virus | Potency | 12.5613 | 1 | 2 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| PPM1D protein | Homo sapiens (human) | Potency | 13.1294 | 1 | 4 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 21.9317 | 3 | 28 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 12.4203 | 1 | 6 |
| progesterone receptor | Homo sapiens (human) | Potency | 31.7978 | 3 | 18 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 13.6932 | 2 | 39 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 195.4851 | 1 | 3 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 1.5003 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 25.4115 | 3 | 68 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 18.4425 | 4 | 53 |
| RGS12 | Homo sapiens (human) | Potency | 1.9953 | 1 | 1 |
| signal transducer and activator of transcription 6, interleukin-4 induced | Homo sapiens (human) | Potency | 31.6228 | 2 | 2 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 46.4758 | 3 | 12 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 46.4758 | 3 | 12 |
| Smad3 | Homo sapiens (human) | Potency | 26.8915 | 1 | 4 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 0.6310 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 15.1563 | 1 | 6 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 8.1067 | 1 | 3 |
| TDP1 protein | Homo sapiens (human) | Potency | 7.2879 | 2 | 33 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 22.3872 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 22.0742 | 3 | 13 |
| Thrombopoietin | Homo sapiens (human) | Potency | 6.5452 | 2 | 4 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 15.9007 | 3 | 31 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 21.3842 | 4 | 19 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 26.0761 | 6 | 40 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 43.0157 | 2 | 3 |
| tumor necrosis factor | Homo sapiens (human) | Potency | 52.4136 | 1 | 2 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 8.4719 | 1 | 2 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 8.4719 | 1 | 2 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 37.3034 | 1 | 5 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 18.1069 | 2 | 16 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 23.4484 | 5 | 26 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 24.3689 | 1 | 3 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 15.5388 | 1 | 13 |
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | Rattus norvegicus (Norway rat) | IC50 | 9.5000 | 1 | 1 |
| 3-oxo-5-alpha-steroid 4-dehydrogenase 2 | Rattus norvegicus (Norway rat) | IC50 | 9.5000 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 3.1700 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 2.0170 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | IC50 | 2.1430 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 1.1220 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | IC50 | 2.1430 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | Ki | 1.1220 | 1 | 1 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 7.2500 | 1 | 1 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | IC50 | 113.5000 | 2 | 2 |
| Adenosine receptor A1 | Cavia porcellus (domestic guinea pig) | Ki | 100.0000 | 5 | 5 |
| Adenosine receptor A1 | Homo sapiens (human) | Ki | 35.4333 | 15 | 15 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | Ki | 37.5909 | 30 | 33 |
| Adenosine receptor A2a | Homo sapiens (human) | IC50 | 20.4720 | 1 | 1 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | IC50 | 63.0000 | 1 | 5 |
| Adenosine receptor A2a | Cavia porcellus (domestic guinea pig) | Ki | 50.0000 | 3 | 3 |
| Adenosine receptor A2a | Homo sapiens (human) | Ki | 20.5069 | 21 | 21 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | Ki | 160.9033 | 25 | 30 |
| Adenosine receptor A2b | Rattus norvegicus (Norway rat) | IC50 | 63.0000 | 1 | 5 |
| Adenosine receptor A2b | Homo sapiens (human) | Ki | 26.7211 | 19 | 19 |
| Adenosine receptor A2b | Mus musculus (house mouse) | Ki | 23.0000 | 1 | 1 |
| Adenosine receptor A2b | Rattus norvegicus (Norway rat) | Ki | 35.3050 | 15 | 20 |
| Adenosine receptor A3 | Homo sapiens (human) | Ki | 34.9750 | 12 | 12 |
| Adenosine receptor A3 | Rattus norvegicus (Norway rat) | Ki | 56.6667 | 6 | 6 |
| Alcohol dehydrogenase E chain | Equus caballus (horse) | Ki | 7,762.4700 | 1 | 1 |
| Alcohol dehydrogenase S chain | Equus caballus (horse) | Ki | 7,762.4700 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 8.5950 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 8.5240 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 21.0610 | 1 | 1 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 74.0000 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 7.8980 | 1 | 1 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 74.0000 | 1 | 1 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 74.0000 | 1 | 1 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 | 22.2648 | 4 | 4 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | IC50 | 81.0000 | 2 | 2 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | Ki | 3,700.0000 | 2 | 2 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 50.0000 | 3 | 3 |
| ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | IC50 | 50.0000 | 4 | 4 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 358.0625 | 3 | 8 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | IC50 | 14,000.0000 | 1 | 1 |
| Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B | Rattus norvegicus (Norway rat) | IC50 | 70.0000 | 1 | 1 |
| Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C | Rattus norvegicus (Norway rat) | IC50 | 70.0000 | 1 | 1 |
| Calmodulin-1 | Homo sapiens (human) | IC50 | 72.0000 | 2 | 2 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A | Homo sapiens (human) | IC50 | 747.0000 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Carbonic anhydrase | Methanosarcina thermophila | Ki | 80,100.0000 | 3 | 8 |
| Carbonic anhydrase | Astrosclera willeyana | Ki | 9,686.6667 | 1 | 3 |
| Carbonic anhydrase | Pseudomonas aeruginosa PAO1 | Ki | 35,923.3333 | 1 | 3 |
| Carbonic anhydrase 1 | Homo sapiens (human) | IC50 | 28,500.0000 | 1 | 2 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 101,182.2545 | 8 | 22 |
| Carbonic anhydrase 2 | Homo sapiens (human) | IC50 | 28,500.0000 | 1 | 2 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 124,531.1765 | 18 | 51 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 65,100.0000 | 1 | 1 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 300.0000 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 5.0000 | 1 | 1 |
| carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1 | Homo sapiens (human) | IC50 | 20.7330 | 1 | 1 |
| Chain A, Chitinase | Clonostachys rosea | Ki | 19,700.0000 | 1 | 1 |
| Chain A, Glycogen Phosphorylase | Oryctolagus cuniculus (rabbit) | Ki | 100.0000 | 1 | 1 |
| Chitotriosidase-1 | Homo sapiens (human) | IC50 | 363.0000 | 1 | 2 |
| Cholinesterase | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Cyclin-dependent kinase 2 | Homo sapiens (human) | IC50 | 42.5000 | 2 | 4 |
| Cyclin-dependent kinase 5 activator 1 | Homo sapiens (human) | IC50 | 0.2000 | 1 | 1 |
| Cyclin-dependent-like kinase 5 | Homo sapiens (human) | IC50 | 0.2000 | 1 | 1 |
| Cyclin-dependent-like kinase 5 | Homo sapiens (human) | Ki | 0.1700 | 1 | 2 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 0.0440 | 1 | 3 |
| Cytochrome P450 1B1 | Homo sapiens (human) | IC50 | 0.0090 | 1 | 1 |
| Cytochrome P450 2A6 | Homo sapiens (human) | IC50 | 187.0000 | 1 | 2 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 1.5000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 118.5000 | 2 | 2 |
| Dihydrofolate reductase | Escherichia coli K-12 | IC50 | 0.0110 | 1 | 1 |
| Dihydrofolate reductase | Homo sapiens (human) | IC50 | 0.0201 | 6 | 6 |
| Dihydrofolate reductase | Lacticaseibacillus casei | IC50 | 0.0050 | 1 | 1 |
| Dihydrofolate reductase | Mus musculus (house mouse) | IC50 | 0.0253 | 6 | 6 |
| Dihydrofolate reductase | Homo sapiens (human) | Ki | 0.0001 | 3 | 3 |
| Dihydrofolate reductase | Mus musculus (house mouse) | Ki | 0.0000 | 3 | 3 |
| Discoidin domain-containing receptor 2 | Homo sapiens (human) | IC50 | 9.0000 | 1 | 1 |
| DNA-(apurinic or apyrimidinic site) endonuclease | Homo sapiens (human) | IC50 | 3.3600 | 2 | 3 |
| DNA-dependent protein kinase catalytic subunit | Homo sapiens (human) | IC50 | 10,000.0000 | 1 | 1 |
| Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 | Saccharomyces cerevisiae S288C | Ki | 0.0410 | 1 | 1 |
| Endochitinase B1 | Aspergillus fumigatus | IC50 | 363.0000 | 1 | 2 |
| Eyes absent homolog 2 | Homo sapiens (human) | IC50 | 6,600.0000 | 1 | 1 |
| Fibroblast growth factor receptor 4 | Homo sapiens (human) | IC50 | 0.9380 | 1 | 1 |
| Folylpolyglutamate synthase, mitochondrial | Mus musculus (house mouse) | Ki | 17.6000 | 1 | 1 |
| Genome polyprotein | IC50 | 3.8000 | 1 | 1 | |
| Glycogen phosphorylase, liver form | Rattus norvegicus (Norway rat) | IC50 | 648.0000 | 1 | 1 |
| Glycogen phosphorylase, muscle form | Oryctolagus cuniculus (rabbit) | IC50 | 159.1933 | 13 | 15 |
| Glycogen phosphorylase, muscle form | Rattus norvegicus (Norway rat) | IC50 | 182.0000 | 1 | 1 |
| Growth factor receptor-bound protein 2 | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Growth factor receptor-bound protein 2 | Mus musculus (house mouse) | IC50 | 5.0000 | 1 | 1 |
| Guanine deaminase | Homo sapiens (human) | Ki | 10.2000 | 1 | 1 |
| Integrase | Human immunodeficiency virus 1 | IC50 | 23,000.6000 | 2 | 2 |
| Laccase | Trametes versicolor | IC50 | 266.3333 | 3 | 3 |
| Lysine-specific histone demethylase 1A | Homo sapiens (human) | IC50 | 19.1600 | 1 | 1 |
| Methylated-DNA--protein-cysteine methyltransferase | Homo sapiens (human) | IC50 | 338.0000 | 2 | 2 |
| Microtubule-associated protein tau | Rattus norvegicus (Norway rat) | IC50 | 0.2000 | 1 | 1 |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 130,170.0000 | 1 | 3 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Neuraminidase | Influenza A virus (A/Wilson-Smith/1933(H1N1)) | IC50 | 100.0000 | 3 | 3 |
| Nischarin | Rattus norvegicus (Norway rat) | IC50 | 70.0000 | 1 | 1 |
| nuclear receptor subfamily 0 group B member 1 | Homo sapiens (human) | IC50 | 67.5680 | 1 | 1 |
| Palmitoleoyl-protein carboxylesterase NOTUM | Homo sapiens (human) | IC50 | 18.6000 | 1 | 1 |
| Pantothenate synthetase | Mycobacterium tuberculosis H37Rv | IC50 | 250.7200 | 2 | 2 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | Homo sapiens (human) | IC50 | 3,630.0000 | 1 | 1 |
| Phosphodiesterase | Rattus norvegicus (Norway rat) | IC50 | 70.0000 | 1 | 1 |
| Poly [ADP-ribose] polymerase 1 | Homo sapiens (human) | IC50 | 0.3445 | 7 | 8 |
| Poly [ADP-ribose] polymerase 1 | Bos taurus (cattle) | IC50 | 0.3000 | 1 | 1 |
| Poly [ADP-ribose] polymerase 2 | Mus musculus (house mouse) | IC50 | 0.2080 | 1 | 2 |
| Poly [ADP-ribose] polymerase tankyrase-1 | Homo sapiens (human) | IC50 | 0.1111 | 1 | 2 |
| Poly [ADP-ribose] polymerase tankyrase-2 | Homo sapiens (human) | IC50 | 0.0139 | 1 | 2 |
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 210.0000 | 1 | 1 |
| Protein mono-ADP-ribosyltransferase PARP15 | Homo sapiens (human) | IC50 | 2.4559 | 1 | 2 |
| RAD51 | Homo sapiens (human) | IC50 | 58.5500 | 2 | 2 |
| Renin | Homo sapiens (human) | Ki | 15.0000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 100.0000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | IC50 | 100.0000 | 1 | 1 |
| Reverse transcriptase/RNaseH | Human immunodeficiency virus 1 | IC50 | 270.0000 | 1 | 1 |
| Ribosyldihydronicotinamide dehydrogenase [quinone] | Homo sapiens (human) | IC50 | 0.4450 | 2 | 2 |
| Serine-protein kinase ATM | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| Serine/threonine-protein kinase ATR | Homo sapiens (human) | IC50 | 1,100.0000 | 1 | 1 |
| Serine/threonine-protein kinase mTOR | Homo sapiens (human) | IC50 | 400.0000 | 1 | 1 |
| Serine/threonine-protein kinase pim-1 | Homo sapiens (human) | IC50 | 4.3000 | 1 | 1 |
| Similar to alpha-tubulin isoform 1 | Bos taurus (cattle) | IC50 | 3.5316 | 20 | 38 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 8.5950 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 8.5240 | 1 | 1 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 6.0530 | 1 | 1 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | Ki | 3.2160 | 1 | 1 |
| Solute carrier family 22 member 3 | Homo sapiens (human) | Ki | 0.1200 | 1 | 1 |
| Solute carrier organic anion transporter family member 1A3 | Rattus norvegicus (Norway rat) | Ki | 0.5000 | 1 | 1 |
| steroidogenic factor 1 | Homo sapiens (human) | IC50 | 67.5680 | 1 | 1 |
| Substance-K receptor | Cavia porcellus (domestic guinea pig) | IC50 | 100.0000 | 1 | 1 |
| Substance-P receptor | Cavia porcellus (domestic guinea pig) | IC50 | 100.0000 | 1 | 1 |
| Thymidylate kinase | Mycobacterium tuberculosis H37Rv | Ki | 521.0000 | 1 | 1 |
| Trypanothione reductase | Trypanosoma cruzi | Ki | 38.0000 | 1 | 1 |
| Tubulin alpha-1A chain | Homo sapiens (human) | IC50 | 22.8838 | 39 | 39 |
| Tubulin alpha-1A chain | Sus scrofa (pig) | IC50 | 4.6759 | 28 | 28 |
| Tubulin alpha-1A chain | Homo sapiens (human) | Ki | 2.4000 | 1 | 1 |
| Tubulin alpha-1A chain | Sus scrofa (pig) | Ki | 5.7500 | 1 | 1 |
| Tubulin alpha-1B chain | Homo sapiens (human) | IC50 | 22.8838 | 39 | 39 |
| Tubulin alpha-1B chain | Homo sapiens (human) | Ki | 2.4000 | 1 | 1 |
| Tubulin alpha-1C chain | Homo sapiens (human) | IC50 | 22.8838 | 39 | 39 |
| Tubulin alpha-1C chain | Homo sapiens (human) | Ki | 2.4000 | 1 | 1 |
| Tubulin alpha-3C chain | Homo sapiens (human) | IC50 | 22.8838 | 39 | 39 |
| Tubulin alpha-3C chain | Homo sapiens (human) | Ki | 2.4000 | 1 | 1 |
| Tubulin alpha-3E chain | Homo sapiens (human) | IC50 | 22.8838 | 39 | 39 |
| Tubulin alpha-3E chain | Homo sapiens (human) | Ki | 2.4000 | 1 | 1 |
| Tubulin alpha-4A chain | Homo sapiens (human) | IC50 | 22.8838 | 39 | 39 |
| Tubulin alpha-4A chain | Homo sapiens (human) | Ki | 2.4000 | 1 | 1 |
| Tubulin beta chain | Homo sapiens (human) | IC50 | 21.7071 | 42 | 42 |
| Tubulin beta chain | Sus scrofa (pig) | IC50 | 4.8445 | 26 | 26 |
| Tubulin beta chain | Homo sapiens (human) | Ki | 2.4000 | 1 | 1 |
| Tubulin beta chain | Sus scrofa (pig) | Ki | 5.7500 | 1 | 1 |
| Tubulin beta-1 chain | Homo sapiens (human) | IC50 | 22.8838 | 39 | 39 |
| Tubulin beta-1 chain | Homo sapiens (human) | Ki | 2.4000 | 1 | 1 |
| Tubulin beta-2A chain | Homo sapiens (human) | IC50 | 22.8838 | 39 | 39 |
| Tubulin beta-2A chain | Homo sapiens (human) | Ki | 2.4000 | 1 | 1 |
| Tubulin beta-2B chain | Bos taurus (cattle) | IC50 | 469.7233 | 24 | 24 |
| Tubulin beta-2B chain | Homo sapiens (human) | IC50 | 22.8838 | 39 | 39 |
| Tubulin beta-2B chain | Bos taurus (cattle) | Ki | 0.7800 | 1 | 1 |
| Tubulin beta-2B chain | Homo sapiens (human) | Ki | 2.4000 | 1 | 1 |
| Tubulin beta-3 chain | Homo sapiens (human) | IC50 | 22.8838 | 39 | 39 |
| Tubulin beta-3 chain | Homo sapiens (human) | Ki | 2.4000 | 1 | 1 |
| Tubulin beta-4A chain | Homo sapiens (human) | IC50 | 22.8838 | 39 | 39 |
| Tubulin beta-4A chain | Homo sapiens (human) | Ki | 2.4000 | 1 | 1 |
| Tubulin beta-4B chain | Homo sapiens (human) | IC50 | 22.8838 | 39 | 39 |
| Tubulin beta-4B chain | Homo sapiens (human) | Ki | 2.4000 | 1 | 1 |
| Tubulin beta-6 chain | Homo sapiens (human) | IC50 | 22.8838 | 39 | 39 |
| Tubulin beta-6 chain | Homo sapiens (human) | Ki | 2.4000 | 1 | 1 |
| Tubulin beta-8 chain | Homo sapiens (human) | IC50 | 22.8838 | 39 | 39 |
| Tubulin beta-8 chain | Homo sapiens (human) | Ki | 2.4000 | 1 | 1 |
| Vesicular acetylcholine transporter | Tetronarce californica (Pacific electric ray) | IC50 | 2.6200 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
Activation Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Adenosine receptor A1 | Homo sapiens (human) | Kd | 45.0000 | 1 | 1 |
| Adenosine receptor A2a | Homo sapiens (human) | Kd | 15.3144 | 2 | 2 |
| Chain A, Glycogen phosphorylase, liver form | Homo sapiens (human) | Kd | 100.0000 | 1 | 8 |
| DNA-(apurinic or apyrimidinic site) endonuclease | Homo sapiens (human) | Kd | 0.0495 | 1 | 2 |
| Heparanase | Homo sapiens (human) | Kd | 1,000.0000 | 1 | 1 |
| ORF73 | Human gammaherpesvirus 8 | EC50 | 75.0000 | 1 | 2 |
| Palmitoleoyl-protein carboxylesterase NOTUM | Homo sapiens (human) | EC50 | 45.8000 | 1 | 1 |
| Palmitoleoyl-protein carboxylesterase NOTUM | Homo sapiens (human) | Kd | 85.0000 | 1 | 1 |
| Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase | Homo sapiens (human) | Kd | 88.5000 | 1 | 1 |
| Potassium channel subfamily K member 2 | Homo sapiens (human) | EC50 | 377.0000 | 1 | 1 |
| Tubulin alpha-1A chain | Homo sapiens (human) | EC50 | 0.2000 | 1 | 1 |
| Tubulin alpha-1A chain | Homo sapiens (human) | Kd | 5.6790 | 2 | 2 |
| Tubulin alpha-1A chain | Sus scrofa (pig) | Kd | 7.5000 | 2 | 2 |
| Tubulin alpha-1B chain | Homo sapiens (human) | EC50 | 0.2000 | 1 | 1 |
| Tubulin alpha-1B chain | Homo sapiens (human) | Kd | 5.6790 | 2 | 2 |
| Tubulin alpha-1C chain | Homo sapiens (human) | EC50 | 0.2000 | 1 | 1 |
| Tubulin alpha-1C chain | Homo sapiens (human) | Kd | 5.6790 | 2 | 2 |
| Tubulin alpha-3C chain | Homo sapiens (human) | EC50 | 0.2000 | 1 | 1 |
| Tubulin alpha-3C chain | Homo sapiens (human) | Kd | 5.6790 | 2 | 2 |
| Tubulin alpha-3E chain | Homo sapiens (human) | EC50 | 0.2000 | 1 | 1 |
| Tubulin alpha-3E chain | Homo sapiens (human) | Kd | 5.6790 | 2 | 2 |
| Tubulin alpha-4A chain | Homo sapiens (human) | EC50 | 0.2000 | 1 | 1 |
| Tubulin alpha-4A chain | Homo sapiens (human) | Kd | 5.6790 | 2 | 2 |
| Tubulin beta chain | Homo sapiens (human) | EC50 | 0.2000 | 1 | 1 |
| Tubulin beta chain | Homo sapiens (human) | Kd | 5.6790 | 2 | 2 |
| Tubulin beta chain | Sus scrofa (pig) | Kd | 7.5000 | 2 | 2 |
| Tubulin beta-1 chain | Homo sapiens (human) | EC50 | 0.2000 | 1 | 1 |
| Tubulin beta-1 chain | Homo sapiens (human) | Kd | 5.6790 | 2 | 2 |
| Tubulin beta-2A chain | Homo sapiens (human) | EC50 | 0.2000 | 1 | 1 |
| Tubulin beta-2A chain | Homo sapiens (human) | Kd | 5.6790 | 2 | 2 |
| Tubulin beta-2B chain | Homo sapiens (human) | EC50 | 0.2000 | 1 | 1 |
| Tubulin beta-2B chain | Homo sapiens (human) | Kd | 5.6790 | 2 | 2 |
| Tubulin beta-3 chain | Homo sapiens (human) | EC50 | 0.2000 | 1 | 1 |
| Tubulin beta-3 chain | Homo sapiens (human) | Kd | 5.6790 | 2 | 2 |
| Tubulin beta-4A chain | Homo sapiens (human) | EC50 | 0.2000 | 1 | 1 |
| Tubulin beta-4A chain | Homo sapiens (human) | Kd | 5.6790 | 2 | 2 |
| Tubulin beta-4B chain | Homo sapiens (human) | EC50 | 0.2000 | 1 | 1 |
| Tubulin beta-4B chain | Homo sapiens (human) | Kd | 5.6790 | 2 | 2 |
| Tubulin beta-6 chain | Homo sapiens (human) | EC50 | 0.2000 | 1 | 1 |
| Tubulin beta-6 chain | Homo sapiens (human) | Kd | 5.6790 | 2 | 2 |
| Tubulin beta-8 chain | Homo sapiens (human) | EC50 | 0.2000 | 1 | 1 |
| Tubulin beta-8 chain | Homo sapiens (human) | Kd | 5.6790 | 2 | 2 |
| Tubulin polymerization-promoting protein | Bos taurus (cattle) | EC50 | 0.7500 | 1 | 1 |
Other Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | ID50 | 0.0400 | 1 | 1 |
| Adenosine receptor A1 | Homo sapiens (human) | Affinity constant | 30.0000 | 1 | 1 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | Kb | 60.0000 | 1 | 4 |
| Adenosine receptor A1 | Homo sapiens (human) | KD hydro | 150,000.0000 | 1 | 1 |
| Adenosine receptor A2a | Homo sapiens (human) | Affinity constant | 30.0000 | 1 | 1 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | Kb | 36.0000 | 1 | 1 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | Ratio | 48.0000 | 1 | 2 |
| Adenosine receptor A2b | Homo sapiens (human) | Affinity constant | 30.0000 | 1 | 1 |
| Adenosine receptor A2b | Mus musculus (house mouse) | Kb | 25.0000 | 1 | 1 |
| Adenosine receptor A2b | Rattus norvegicus (Norway rat) | Ratio | 48.0000 | 1 | 2 |
| Adenylate cyclase type 1 | Homo sapiens (human) | Kb | 30.0000 | 1 | 1 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | Km | 18.7767 | 2 | 3 |
| Dihydrofolate reductase | Lacticaseibacillus casei | ID50 | 0.0270 | 1 | 1 |
| Dihydrofolate reductase | Mus musculus (house mouse) | ID50 | 0.0211 | 2 | 2 |
| DNA repair and recombination protein RAD54-like isoform 1 | Homo sapiens (human) | AC50 | 6.9500 | 1 | 1 |
| DNA repair protein RAD52 homolog isoform a | Homo sapiens (human) | AC50 | 9.3300 | 1 | 1 |
| Folylpolyglutamate synthase, mitochondrial | Homo sapiens (human) | Km | 4.2591 | 11 | 11 |
| Folylpolyglutamate synthase, mitochondrial | Mus musculus (house mouse) | Km | 8,800,010.0000 | 2 | 2 |
| Folylpolyglutamate synthase, mitochondrial | Homo sapiens (human) | Vmax | 1.0000 | 1 | 1 |
| Methylated-DNA--protein-cysteine methyltransferase | Homo sapiens (human) | ED50 | 235.0000 | 2 | 2 |
| Muscarinic acetylcholine receptor | Cavia porcellus (domestic guinea pig) | Kb | 25.0000 | 1 | 1 |
| PAX8 | Homo sapiens (human) | AC50 | 0.2600 | 1 | 1 |
| Plasma kallikrein | Homo sapiens (human) | Activity | 1.0600 | 1 | 1 |
| Tubulin alpha-1A chain | Homo sapiens (human) | Activity | 9.4733 | 9 | 9 |
| Tubulin alpha-1B chain | Homo sapiens (human) | Activity | 9.4733 | 9 | 9 |
| Tubulin alpha-1C chain | Homo sapiens (human) | Activity | 9.4733 | 9 | 9 |
| Tubulin alpha-3C chain | Homo sapiens (human) | Activity | 9.4733 | 9 | 9 |
| Tubulin alpha-3E chain | Homo sapiens (human) | Activity | 9.4733 | 9 | 9 |
| Tubulin alpha-4A chain | Homo sapiens (human) | Activity | 9.4733 | 9 | 9 |
| Tubulin beta chain | Homo sapiens (human) | Activity | 9.4733 | 9 | 9 |
| Tubulin beta-1 chain | Homo sapiens (human) | Activity | 9.4733 | 9 | 9 |
| Tubulin beta-2A chain | Homo sapiens (human) | Activity | 9.4733 | 9 | 9 |
| Tubulin beta-2B chain | Homo sapiens (human) | Activity | 9.4733 | 9 | 9 |
| Tubulin beta-3 chain | Homo sapiens (human) | Activity | 9.4733 | 9 | 9 |
| Tubulin beta-4A chain | Homo sapiens (human) | Activity | 9.4733 | 9 | 9 |
| Tubulin beta-4B chain | Homo sapiens (human) | Activity | 9.4733 | 9 | 9 |
| Tubulin beta-6 chain | Homo sapiens (human) | Activity | 9.4733 | 9 | 9 |
| Tubulin beta-8 chain | Homo sapiens (human) | Activity | 9.4733 | 9 | 9 |
| Vasopressin V2 receptor | Sus scrofa (pig) | Kb | 30.0000 | 1 | 1 |