Page last updated: 2024-08-05 14:23:34

mutagen

An agent that increases the frequency of mutations above the normal background level, usually by interacting directly with DNA and causing it damage, including base substitution.

ChEBI ID: 25435

Members (83)

MemberDefinitionClass
(2e)-decenalA dec-2-enal in which the olefinic double bond has E configuration.(2E)-dec-2-enal
1-amino-2-naphthol-4-sulfonic acid4-amino-3-hydroxynaphthalene-1-sulfonic acid
1-bromo-2-chloroethaneA haloalkane that is bromoethane substituted by chlorine at position 2.1-bromo-2-chloroethane
1-methylphenanthreneA member of the class of phenanthrenes that is phenanthrene substituted by a methyl group at position 1.1-methylphenanthrene
1,2,5,6-dibenzanthracenedibenz[a,h]anthracene
1,2,7,8-diepoxyoctane1,2:7,8-diepoxyoctane
1,3-butadieneA butadiene with unsaturation at positions 1 and 3.buta-1,3-diene
1,n(6)-ethenoadenine1H-imidazo[2,1-i]purine; 3H-imidazo[2,1-i]purine
2-acetylaminofluoreneThe parent of the class of 2-acetamidofluorenes, being an ortho-fused polycyclic arene that consists of 9H-fluorene bearing an acetamido substituent at position 2. It is a carcinogenic and mutagenic derivative of fluorene.2-acetamidofluorene
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridineAn imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.PhIP
2-amino-3,8-dimethylimidazo(4,5-f)quinoxalineAn imidazoquinoxaline that is 3H-imidazo[4,5-f]quinoxaline substituted at positions 3 and 8 by methyl groups and at position 2 by an amino group. A mutagenic compound found in cooked beef.MeIQx
2-amino-n(6)-hydroxyadenineA 2,6-diaminopurine that is the N(6)-hydroxy derivative of 2,6-diamino-3H-purine.2-amino-6-hydroxyaminopurine
2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridineAn imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, hydoxyamino, and phenyl groups, respectively. The active metabolite of the dietary carcinogen PhIP.N-hydroxy-PhIP
2-nitrofluoreneA nitroarene that is fluorene substituted by a nitro group at position 2.2-nitrofluorene
2,6-diaminotolueneA diamine that is toluene in which both of the hydrogens ortho- to the methyl group are replaced by amino groups.2,6-diaminotoluene
3,n(4)-ethanocytosine3,N(4)-ethenocytosine
4-methylquinolineA methylquinoline carrying a methyl substituent at position 4.4-methylquinoline
4-nitrobenzyl chlorideA C-nitro compound that is nitrobenzene in which the hydrogen at position 4 is replaced by a chloromethyl group.p-nitrobenzyl chloride
4-nitrophenylhydrazineA member of the class of phenylhydrazines that is phenylhydrazine substituted at the 4-position by a nitro group.4-nitrophenylhydrazine
5-bromouridineA uridine having a bromo substituent at the 5-position.5-bromouridine
5-fluorouridineAn organofluorine compound that is uridine bearing a fluoro substituent at position 5 on the uracil ring.5-fluorouridine
5-formyluracilA pyrimidone resulting from the formal oxidation of the alcoholic hydroxy group of 5-hydroxymethyluracil to the corresponding aldehyde. It is a major one-electron photooxidation product of thymine in oligodeoxynucleotides.5-formyluracil
6-n-hydroxylaminopurineA member of the class of 6-aminopurinnes that is adenine in which one of the exocyclic amino hydrogens is replaced by a hydroxy group.N(6)-hydroxyadenine
8-oxodeoxyguanosine triphosphateA purine 2'-deoxyribonucleoside 5'-triphosphate having 8-oxo-7,8-dihydroguanine as the nucleobase.8-oxo-dGTP
acetaldehydeThe aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.acetaldehyde
acetoxyacetylaminofluoreneA 2-acetamidofluorene compound in which the parent 2-acetamidofluorene is substituted on nitrogen by an acetoxy group.N-acetoxy-2-acetamidofluorene
acridine half-mustardA member of the class of aminoacridines that is acridine which is substituted by a methoxy group at position 2, chlorine at position 6, and a {3-[(2-chloroethyl)amino]propyl}amino group at position 9.acridine half-mustard
acrylamideA member of the class of acrylamides that results from the formal condensation of acrylic acid with ammonia.acrylamide
acrylonitrileA nitrile that is hydrogen cyanide in which the hydrogen has been replaced by an ethenyl group.acrylonitrile
aminacrineAn aminoacridine that is acridine in which the hydrogen at position 9 is replaced by an amino group. A fluorescent dyd and topical antiseptic agent, it is used (usually as the hydrochloride salt) in eye drops for the treatment of superficial eye infections.9-aminoacridine
aminopterin4-aminofolic acid
aristolochic acid cAn aristolochic acid that is phenanthrene-1-carboxylic acid substituted by a methylenedioxy group at the 3,4 positions, by an hydroxy group at position 6, and by a nitro group at position 10.aristolochic acid C
aristolochic acid iAn aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.aristolochic acid A
aristolochic acid iiAn aristolochic acid that is phenanthrene-1-carboxylic acid substituted by a methylenedioxy group at the 3,4 positions and by a nitro group at position 10.aristolochic acid B
benzo(b)fluorantheneAn ortho- and peri-fused polycyclic arene that consists of a benzene ring fused with a acephenanthrylene ring.benzo[b]fluoranthene
benzo(e)pyreneAn ortho- and peri-fused polycyclic arene consisting of five fused benzene rings. It is listed as a Group 3 carcinogen by the IARC.benzo[e]pyrene
bromouracilA pyrimidine having keto groups at the 2- and 4-positions and a bromo group at the 5-position. Used mainly as an experimental mutagen.5-bromouracil
c.i. solvent yellow 56An azobenzene that is N,N-diethylaniline substituted at position 4 by a phenylazo group.Solvent yellow 56
caffeineA trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee.caffeine
cisplatinA diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).cisplatin; transplatin
colchicineA colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions.(S)-colchicine
dactinomycinactinomycin D
demethylbellidifolinA member of the class of xanthones that is xanthone which is substituted by hydroxy groups at positions 1, 3, 5, and 8. A natural product found particularly in Iris nigricans and Gentiana campestris.bellidin
dibenzo(a,l)pyrenedibenzo[a,l]pyrene
diepoxybutanediepoxybutane
diethyl sulfateThe diethyl ester of sulfuric acid.diethyl sulfate
diethylnitrosamineA nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.N-nitrosodiethylamine
dimethylmyleranA methanesulfonate ester that is hexane-2,5-diol in which the hydrogens of the hydroxy groups are replaced by methanesulfonyl groups.dimethylmyleran
dimethylnitrosamineN-nitrosodimethylamine
ethyl methanesulfonateA methanesulfonate ester resulting from the formal condensation of methanesulfonic acid with ethanol.ethyl methanesulfonate
ethylene dibromideA bromoalkane that is ethane carrying bromo substituents at positions 1 and 2. It is produced by marine algae.1,2-dibromoethane
ethylene dichlorideA member of the class of chloroethanes substituted by two chloro groups at positions 1 and 2.1,2-dichloroethane
ethylene oxideA saturated organic heteromonocyclic parent that is a three-membered heterocycle of two carbon atoms and one oxygen atom.oxirane
ethylenimine quinoneA member of the class of 1,4-benzoquinones that is p-benzoquinone in which the hydrogens at positions 2 and 5 are replaced by aziridin-1-yl groups.2,5-bis(aziridin-1-yl)-1,4-benzoquinone
ethylnitrosoureaA member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by ethyl and nitroso groups.N-ethyl-N-nitrosourea
fagaroninefagaronine
ferric nitrilotriacetateAn iron chelate resulting from the combination of equimolar amounts of iron(3+) and nitrilotriacetate(3-).iron(III) nitrilotriacetate
hempahexamethylphosphoric triamide
hesperidinA disaccharide derivative that consists of hesperetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.hesperidin
hycanthoneA thioxanthen-9-one compound having a hydroxymethyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. It was formerly used (particularly as the monomethanesulfonic acid salt) as a schistosomicide for individual or mass treatement of infection with Schistosoma haematobium and S. mansoni, but due to its toxicity and concern about possible carcinogenicity, it has been replaced by other drugs such as praziquantel.hycanthone
hycanthone methanesulfonateA methanesulfonate salt resulting from the reaction of equimolar amounts of hycanthone and methanesulfonic acid. It was formerly used as a schistosomicide for individual or mass treatement of infection with Schistosoma haematobium and S. mansoni, but due to its toxicity and concern about possible carcinogenicity, it has been replaced by other drugs such as praziquantel.hycanthone mesylate
lucanthoneA thioxanthen-9-one compound having a methyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. Formerly used for the treatment of schistosomiasis. It is a prodrug, being metabolised to hycanthone.lucanthone
methoxyacetic acidA monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by a methoxy group.methoxyacetic acid
methyl chlorideA one-carbon compound that is methane in which one of the hydrogens is replaced by a chloro group.chloromethane
methyl methanesulfonateA methanesulfonate ester resulting from the formal condensation of methanesulfonic acid with methanol.methyl methanesulfonate
methylnitrosoureaA member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by methyl and nitroso groups.N-methyl-N-nitrosourea
myosmineA member of the class of pyridines that is pyridine substituted by a 3,4-dihydro-2H-pyrrol-5-yl group at position 3. It is an alkaloid found in tobacco plants and exhibits genotoxic effects.myosmine
n-nitrosomorpholineA nitrosamine that is morpholine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. A carcinogen and mutagen, it is found in snuff tobacco.N-nitrosomorpholine
n-nitrosopiperidineA nitrosamine that is piperidine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. One of the many carcinogens detected in cigarette smoke, it is found in meat, cheese and spices that have been treated with the preservative sodium nitrite.N-nitrosopiperidine
nitrosocarbarylA nitroso compound that is carbaryl in which the amino hydrogen is substituted by a nitroso group.nitrosocarbaryl
o-(6)-methylguanineA methylguanine in which the methyl group is positioned on the oxygen at position 6. Formed in DNA by alkylation of the oxygen atom of guanine, most often by N-nitroso compounds and sometimes due to methylation by other compounds such as endogenous S-adenosylmethionine, it base-pairs to thymine rather than cytidine, causing a G:C to A:T transition in DNA.6-O-methylguanine
ozoneAn elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.ozone
patulinA furopyran and lactone that is (2H-pyran-3(6H)-ylidene)acetic acid which is substituted by hydroxy groups at positions 2 and 4 and in which the hydroxy group at position 4 has condensed with the carboxy group to give the corresponding bicyclic lactone. A mycotoxin produced by several species of Aspergillus and Penicillium, it has antibiotic properties but has been shown to be carcinogenic and mutagenic.patulin
phenanthridoneA member of the class of phenanthridines that is phenanthridine with an oxo substituent at position 6. A poly(ADP-ribose) polymerase (PARP) inhibitor, it has been shown to exhibit immunosuppressive activity.phenanthridone
riddelliineA macrodiolide that is 13,19-didehydrosenecionan bearing two additional hydroxy substituents at positions 12 and 18 as well as two additional oxo groups at positions 11 and 16.riddelliine
riddelliine n-oxideA pyrrolizine alkaloid that is 13,19-didehydrosenecionane bearing two additional hydroxy substituents at positions 12 and 18, two additional oxo groups at positions 11 and 16 and an N-oxido substituent.riddelliine N-oxide
sodium azideThe sodium salt of hydrogen azide (hydrazoic acid).sodium azide
sodium bisulfiteAn inorganic sodium salt having hydrogensulfite as the counterion.sodium hydrogensulfite
sodium fluorideA metal fluoride salt with a Na(+) counterion.sodium fluoride
spiroiminodihydantoinAn azaspiro compound that is 1,3,6,8-tetraazaspiro[4.4]non-6-ene which is substituted by oxo groups at positions 2, 4, and 9. Both enantiomers are highly mutagenic products resulting from the oxidation of guanine and 8-oxo-7,8-dihydroguanine in DNA by reactive oxygen species.spiroiminodihydantoin
styreneA vinylarene that is benzene carrying a vinyl group. It has been isolated from the benzoin resin produced by Styrax species.styrene
urethaneA carbamate ester obtained by the formal condensation of ethanol with carbamic acid. It has been found in alcoholic beverages.urethane
vinylidene chlorideA member of the class of chloroethenes that is ethene in which both of the hydrogens attached to one of the carbons are replaced by chlorines.1,1-dichloroethene

Research

Studies (129,237)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-199048,693 (37.68)18.7374
1990's22,000 (17.02)18.2507
2000's24,188 (18.72)29.6817
2010's24,836 (19.22)24.3611
2020's9,520 (7.37)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials5,048 (3.57%)5.53%
Reviews7,565 (5.35%)6.00%
Case Studies3,605 (2.55%)4.05%
Observational144 (0.10%)0.25%
Other125,131 (88.44%)84.16%

Protein Targets (336)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency11.190414
15-lipoxygenase, partialHomo sapiens (human)Potency17.731413
67.9K proteinVaccinia virusPotency10.7290211
acetylcholinesteraseHomo sapiens (human)Potency44.836949
activating transcription factor 6Homo sapiens (human)Potency26.0641222
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency28.5888120
alpha-galactosidaseHomo sapiens (human)Potency40.074822
Alpha-synucleinHomo sapiens (human)Potency15.848911
Amyloid-beta precursor proteinHomo sapiens (human)Potency20.596211
AR proteinHomo sapiens (human)Potency18.154512122
aryl hydrocarbon receptorHomo sapiens (human)Potency16.3495332
ATAD5 protein, partialHomo sapiens (human)Potency15.172758
Ataxin-2Homo sapiens (human)Potency19.8277112
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency18.563625
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency15.9320218
atrial natriuretic peptide receptor 1 precursorHomo sapiens (human)Potency4.775511
atrial natriuretic peptide receptor 2 precursorHomo sapiens (human)Potency1.849311
Bloom syndrome protein isoform 1Homo sapiens (human)Potency23.004436
BRCA1Homo sapiens (human)Potency35.481311
bromodomain adjacent to zinc finger domain 2BHomo sapiens (human)Potency34.466613
caspase 7, apoptosis-related cysteine proteaseHomo sapiens (human)Potency29.891016
caspase-1 isoform alpha precursorHomo sapiens (human)Potency29.726314
caspase-3Cricetulus griseus (Chinese hamster)Potency33.348414
caspase-3Homo sapiens (human)Potency29.891016
Caspase-7Cricetulus griseus (Chinese hamster)Potency33.348414
Caspase-7Homo sapiens (human)Potency22.106012
Cellular tumor antigen p53Homo sapiens (human)Potency31.2868336
cellular tumor antigen p53 isoform aHomo sapiens (human)Potency11.965125
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency28.051614
Chain A, ATP-DEPENDENT DNA HELICASE Q1Homo sapiens (human)Potency11.482124
Chain A, Beta-lactamaseEscherichia coli K-12Potency5.011911
Chain A, CruzipainTrypanosoma cruziPotency10.806413
Chain A, Ferritin light chainEquus caballus (horse)Potency37.211424
Chain A, HADH2 proteinHomo sapiens (human)Potency24.5035211
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency67.833412
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency26.3106312
Chain A, Putative fructose-1,6-bisphosphate aldolaseGiardia intestinalisPotency14.698412
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency21.283914
Chain B, HADH2 proteinHomo sapiens (human)Potency24.5035211
chaperonin GroELMethanococcus maripaludis S2Potency79.432811
chaperonin-containing TCP-1 beta subunit homologHomo sapiens (human)Potency35.481311
chromobox protein homolog 1Homo sapiens (human)Potency55.8711210
CREB-binding proteinHomo sapiens (human)Potency5.011922
cytochrome P450 2C19 precursorHomo sapiens (human)Potency11.040613
cytochrome P450 2C9 precursorHomo sapiens (human)Potency3.162312
cytochrome P450 2D6Homo sapiens (human)Potency4.364911
cytochrome P450 2D6 isoform 1Homo sapiens (human)Potency15.205613
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency13.6208217
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency15.592123
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency16.4392112
Disintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)Potency15.848911
DNA dC->dU-editing enzyme APOBEC-3F isoform aHomo sapiens (human)Potency7.943311
DNA dC->dU-editing enzyme APOBEC-3G isoform 1Homo sapiens (human)Potency2.238711
DNA polymerase betaHomo sapiens (human)Potency46.650013
DNA polymerase eta isoform 1Homo sapiens (human)Potency89.125111
DNA polymerase III, partialBacillus subtilisPotency18.887611
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency68.938216
DNA polymerase kappa isoform 1Homo sapiens (human)Potency40.863718
endonuclease IVEscherichia coliPotency1.962212
estrogen nuclear receptor alphaHomo sapiens (human)Potency21.633612147
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency40.0984320
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency22.42238106
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency10.4271111
farnesoid X nuclear receptorHomo sapiens (human)Potency28.5488532
flap endonuclease 1Homo sapiens (human)Potency26.501937
Fumarate hydrataseHomo sapiens (human)Potency12.561312
GABA theta subunitRattus norvegicus (Norway rat)Potency13.419619
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency13.419619
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency13.419619
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency13.419619
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency13.419619
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency13.419619
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency13.419619
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency13.419619
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency13.419619
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency13.419619
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency13.419619
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency13.419619
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency13.419619
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency13.419619
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency13.419619
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency13.419619
gemininHomo sapiens (human)Potency8.3287416
GLI family zinc finger 3Homo sapiens (human)Potency13.5303334
glp-1 receptor, partialHomo sapiens (human)Potency19.702012
GLS proteinHomo sapiens (human)Potency27.301326
glucocerebrosidaseHomo sapiens (human)Potency39.810711
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency24.1427543
glucokinase regulatory proteinHomo sapiens (human)Potency31.622811
Glutamate receptor 1Rattus norvegicus (Norway rat)Potency15.848911
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency15.5610214
Glutamate receptor 3Rattus norvegicus (Norway rat)Potency15.848911
Glutamate receptor 4Rattus norvegicus (Norway rat)Potency15.848911
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1Homo sapiens (human)Potency1.995311
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)Homo sapiens (human)Potency16.597812
heat shock protein beta-1Homo sapiens (human)Potency39.3076214
hemoglobin subunit betaHomo sapiens (human)Potency3.981111
hexokinase-4 isoform 1Homo sapiens (human)Potency31.622811
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency3.162316
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency19.952611
histone deacetylase 9 isoform 3Homo sapiens (human)Potency25.9894210
Histone H2A.xCricetulus griseus (Chinese hamster)Potency58.4129213
histone-lysine N-methyltransferase 2A isoform 2 precursorHomo sapiens (human)Potency40.517413
huntingtin isoform 2Homo sapiens (human)Potency6.051434
hypothetical protein, conservedTrypanosoma bruceiPotency1.901211
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency37.0020215
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)Homo sapiens (human)Potency19.922435
IDH1Homo sapiens (human)Potency4.408513
Inositol monophosphatase 1Rattus norvegicus (Norway rat)Potency12.589311
Integrin alpha-IIbHomo sapiens (human)Potency7.943311
Integrin beta-3Homo sapiens (human)Potency7.943311
Interferon betaHomo sapiens (human)Potency12.910728
interleukin 8Homo sapiens (human)Potency37.535117
lamin isoform A-delta10Homo sapiens (human)Potency4.333427
lethal factor (plasmid)Bacillus anthracis str. A2012Potency13.1139111
lethal(3)malignant brain tumor-like protein 1 isoform IHomo sapiens (human)Potency7.079511
LuciferasePhotinus pyralis (common eastern firefly)Potency24.953919
M-phase phosphoprotein 8Homo sapiens (human)Potency2.615712
Microtubule-associated protein tauHomo sapiens (human)Potency14.6479210
mitogen-activated protein kinase 1Homo sapiens (human)Potency27.291525
muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)Potency0.356013
muscleblind-like protein 1 isoform 1Homo sapiens (human)Potency15.407013
neuropeptide S receptor isoform AHomo sapiens (human)Potency13.815412
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency19.2864461
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency6.051113
nuclear factor NF-kappa-B p105 subunit isoform 1Homo sapiens (human)Potency44.668412
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency48.7784212
Nuclear receptor ROR-gammaHomo sapiens (human)Potency2.538219
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency13.9803212
nuclear receptor subfamily 1, group I, member 2Rattus norvegicus (Norway rat)Potency17.782811
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency20.2491357
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency31.622811
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1Homo sapiens (human)Potency38.973524
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency3.682926
peripheral myelin protein 22 isoform 1Homo sapiens (human)Potency76.188412
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency24.0192540
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency23.8855539
phosphoglycerate kinaseTrypanosoma brucei brucei TREU927Potency26.854511
phosphopantetheinyl transferaseBacillus subtilisPotency89.125111
plasminogen precursorMus musculus (house mouse)Potency8.471912
polyproteinZika virusPotency12.561312
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency28.183811
PPM1D proteinHomo sapiens (human)Potency13.129414
pregnane X nuclear receptorHomo sapiens (human)Potency21.9317328
pregnane X receptorRattus norvegicus (Norway rat)Potency12.420316
progesterone receptorHomo sapiens (human)Potency31.7978318
Rap guanine nucleotide exchange factor 3Homo sapiens (human)Potency44.668411
RAR-related orphan receptor gammaMus musculus (house mouse)Potency13.6932239
ras-related protein Rab-9AHomo sapiens (human)Potency195.485113
regulator of G-protein signaling 4Homo sapiens (human)Potency1.500311
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency25.4115368
retinoid X nuclear receptor alphaHomo sapiens (human)Potency18.4425453
RGS12Homo sapiens (human)Potency1.995311
signal transducer and activator of transcription 6, interleukin-4 inducedHomo sapiens (human)Potency31.622822
SMAD family member 2Homo sapiens (human)Potency46.4758312
SMAD family member 3Homo sapiens (human)Potency46.4758312
Smad3Homo sapiens (human)Potency26.891514
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency0.631011
survival motor neuron protein isoform dHomo sapiens (human)Potency15.156316
TAR DNA-binding protein 43Homo sapiens (human)Potency8.106713
TDP1 proteinHomo sapiens (human)Potency7.2879233
thioredoxin glutathione reductaseSchistosoma mansoniPotency22.387211
thioredoxin reductaseRattus norvegicus (Norway rat)Potency22.0742313
ThrombopoietinHomo sapiens (human)Potency6.545224
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency15.9007331
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency21.3842419
thyroid stimulating hormone receptorHomo sapiens (human)Potency26.0761640
thyrotropin-releasing hormone receptorHomo sapiens (human)Potency43.015723
tumor necrosis factorHomo sapiens (human)Potency52.413612
ubiquitin carboxyl-terminal hydrolase 2 isoform aHomo sapiens (human)Potency15.848911
urokinase plasminogen activator surface receptor precursorMus musculus (house mouse)Potency8.471912
urokinase-type plasminogen activator precursorMus musculus (house mouse)Potency8.471912
USP1 protein, partialHomo sapiens (human)Potency37.303415
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency18.1069216
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency23.4484526
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency24.368913
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency15.5388113

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Rattus norvegicus (Norway rat)IC509.500011
3-oxo-5-alpha-steroid 4-dehydrogenase 2Rattus norvegicus (Norway rat)IC509.500011
5-hydroxytryptamine receptor 2BHomo sapiens (human)IC503.170011
5-hydroxytryptamine receptor 2BHomo sapiens (human)Ki2.017011
5-hydroxytryptamine receptor 2CHomo sapiens (human)IC502.143011
5-hydroxytryptamine receptor 2CHomo sapiens (human)Ki1.122011
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)IC502.143011
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)Ki1.122011
AcetylcholinesteraseHomo sapiens (human)IC507.250011
Adenosine receptor A1Rattus norvegicus (Norway rat)IC50113.500022
Adenosine receptor A1Cavia porcellus (domestic guinea pig)Ki100.000055
Adenosine receptor A1Homo sapiens (human)Ki35.43331515
Adenosine receptor A1Rattus norvegicus (Norway rat)Ki37.59093033
Adenosine receptor A2aHomo sapiens (human)IC5020.472011
Adenosine receptor A2aRattus norvegicus (Norway rat)IC5063.000015
Adenosine receptor A2aCavia porcellus (domestic guinea pig)Ki50.000033
Adenosine receptor A2aHomo sapiens (human)Ki20.50692121
Adenosine receptor A2aRattus norvegicus (Norway rat)Ki160.90332530
Adenosine receptor A2bRattus norvegicus (Norway rat)IC5063.000015
Adenosine receptor A2bHomo sapiens (human)Ki26.72111919
Adenosine receptor A2bMus musculus (house mouse)Ki23.000011
Adenosine receptor A2bRattus norvegicus (Norway rat)Ki35.30501520
Adenosine receptor A3Homo sapiens (human)Ki34.97501212
Adenosine receptor A3Rattus norvegicus (Norway rat)Ki56.666766
Alcohol dehydrogenase E chainEquus caballus (horse)Ki7,762.470011
Alcohol dehydrogenase S chainEquus caballus (horse)Ki7,762.470011
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)IC508.595011
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)Ki8.524011
Alpha-2A adrenergic receptorHomo sapiens (human)IC5021.061011
Alpha-2A adrenergic receptorRattus norvegicus (Norway rat)IC5074.000011
Alpha-2A adrenergic receptorHomo sapiens (human)Ki7.898011
Alpha-2B adrenergic receptorRattus norvegicus (Norway rat)IC5074.000011
Alpha-2C adrenergic receptorRattus norvegicus (Norway rat)IC5074.000011
Amine oxidase [flavin-containing] AHomo sapiens (human)IC5022.264844
Amine oxidase [flavin-containing] BHomo sapiens (human)IC5081.000022
Amine oxidase [flavin-containing] BHomo sapiens (human)Ki3,700.000022
ATP-binding cassette sub-family C member 3Homo sapiens (human)IC50133.000012
ATP-dependent translocase ABCB1Homo sapiens (human)IC5050.000033
ATP-dependent translocase ABCB1Mus musculus (house mouse)IC5050.000044
Bile salt export pumpHomo sapiens (human)IC50358.062538
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)IC5014,000.000011
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BRattus norvegicus (Norway rat)IC5070.000011
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1CRattus norvegicus (Norway rat)IC5070.000011
Calmodulin-1Homo sapiens (human)IC5072.000022
cAMP-specific 3',5'-cyclic phosphodiesterase 4AHomo sapiens (human)IC50747.000011
Canalicular multispecific organic anion transporter 1Homo sapiens (human)IC50133.000012
Carbonic anhydraseMethanosarcina thermophilaKi80,100.000038
Carbonic anhydrase Astrosclera willeyanaKi9,686.666713
Carbonic anhydrase Pseudomonas aeruginosa PAO1Ki35,923.333313
Carbonic anhydrase 1Homo sapiens (human)IC5028,500.000012
Carbonic anhydrase 1Homo sapiens (human)Ki101,182.2545822
Carbonic anhydrase 2Homo sapiens (human)IC5028,500.000012
Carbonic anhydrase 2Homo sapiens (human)Ki124,531.17651851
Carbonic anhydrase 4Homo sapiens (human)Ki65,100.000011
Carbonic anhydrase 5A, mitochondrialHomo sapiens (human)Ki300.000011
Carbonic anhydrase 9Homo sapiens (human)Ki5.000011
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1Homo sapiens (human)IC5020.733011
Chain A, ChitinaseClonostachys roseaKi19,700.000011
Chain A, Glycogen PhosphorylaseOryctolagus cuniculus (rabbit)Ki100.000011
Chitotriosidase-1Homo sapiens (human)IC50363.000012
CholinesteraseHomo sapiens (human)IC5050.000011
Cyclin-dependent kinase 2Homo sapiens (human)IC5042.500024
Cyclin-dependent kinase 5 activator 1Homo sapiens (human)IC500.200011
Cyclin-dependent-like kinase 5 Homo sapiens (human)IC500.200011
Cyclin-dependent-like kinase 5 Homo sapiens (human)Ki0.170012
Cytochrome P450 1A2Homo sapiens (human)IC500.044013
Cytochrome P450 1B1Homo sapiens (human)IC500.009011
Cytochrome P450 2A6Homo sapiens (human)IC50187.000012
Cytochrome P450 2D6Homo sapiens (human)IC501.500011
Cytochrome P450 3A4Homo sapiens (human)IC50118.500022
Dihydrofolate reductaseEscherichia coli K-12IC500.011011
Dihydrofolate reductaseHomo sapiens (human)IC500.020166
Dihydrofolate reductaseLacticaseibacillus caseiIC500.005011
Dihydrofolate reductaseMus musculus (house mouse)IC500.025366
Dihydrofolate reductaseHomo sapiens (human)Ki0.000133
Dihydrofolate reductaseMus musculus (house mouse)Ki0.000033
Discoidin domain-containing receptor 2Homo sapiens (human)IC509.000011
DNA-(apurinic or apyrimidinic site) endonucleaseHomo sapiens (human)IC503.360023
DNA-dependent protein kinase catalytic subunitHomo sapiens (human)IC5010,000.000011
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1Saccharomyces cerevisiae S288CKi0.041011
Endochitinase B1Aspergillus fumigatusIC50363.000012
Eyes absent homolog 2Homo sapiens (human)IC506,600.000011
Fibroblast growth factor receptor 4Homo sapiens (human)IC500.938011
Folylpolyglutamate synthase, mitochondrialMus musculus (house mouse)Ki17.600011
Genome polyprotein IC503.800011
Glycogen phosphorylase, liver formRattus norvegicus (Norway rat)IC50648.000011
Glycogen phosphorylase, muscle formOryctolagus cuniculus (rabbit)IC50159.19331315
Glycogen phosphorylase, muscle formRattus norvegicus (Norway rat)IC50182.000011
Growth factor receptor-bound protein 2Homo sapiens (human)IC505.000011
Growth factor receptor-bound protein 2 Mus musculus (house mouse)IC505.000011
Guanine deaminaseHomo sapiens (human)Ki10.200011
Integrase Human immunodeficiency virus 1IC5023,000.600022
Laccase Trametes versicolorIC50266.333333
Lysine-specific histone demethylase 1AHomo sapiens (human)IC5019.160011
Methylated-DNA--protein-cysteine methyltransferaseHomo sapiens (human)IC50338.000022
Microtubule-associated protein tauRattus norvegicus (Norway rat)IC500.200011
Mu-type opioid receptorRattus norvegicus (Norway rat)Ki130,170.000013
Multidrug resistance-associated protein 4Homo sapiens (human)IC50133.000012
Neuraminidase Influenza A virus (A/Wilson-Smith/1933(H1N1))IC50100.000033
NischarinRattus norvegicus (Norway rat)IC5070.000011
nuclear receptor subfamily 0 group B member 1Homo sapiens (human)IC5067.568011
Palmitoleoyl-protein carboxylesterase NOTUMHomo sapiens (human)IC5018.600011
Pantothenate synthetaseMycobacterium tuberculosis H37RvIC50250.720022
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformHomo sapiens (human)IC5020.000011
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Homo sapiens (human)IC503,630.000011
Phosphodiesterase Rattus norvegicus (Norway rat)IC5070.000011
Poly [ADP-ribose] polymerase 1Homo sapiens (human)IC500.344578
Poly [ADP-ribose] polymerase 1 Bos taurus (cattle)IC500.300011
Poly [ADP-ribose] polymerase 2Mus musculus (house mouse)IC500.208012
Poly [ADP-ribose] polymerase tankyrase-1Homo sapiens (human)IC500.111112
Poly [ADP-ribose] polymerase tankyrase-2Homo sapiens (human)IC500.013912
Polyphenol oxidase 2Agaricus bisporusIC50210.000011
Protein mono-ADP-ribosyltransferase PARP15Homo sapiens (human)IC502.455912
RAD51Homo sapiens (human)IC5058.550022
ReninHomo sapiens (human)Ki15.000011
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2IC50100.000011
Replicase polyprotein 1abSevere acute respiratory syndrome-related coronavirusIC50100.000011
Reverse transcriptase/RNaseH Human immunodeficiency virus 1IC50270.000011
Ribosyldihydronicotinamide dehydrogenase [quinone]Homo sapiens (human)IC500.445022
Serine-protein kinase ATMHomo sapiens (human)IC50200.000011
Serine/threonine-protein kinase ATRHomo sapiens (human)IC501,100.000011
Serine/threonine-protein kinase mTORHomo sapiens (human)IC50400.000011
Serine/threonine-protein kinase pim-1Homo sapiens (human)IC504.300011
Similar to alpha-tubulin isoform 1 Bos taurus (cattle)IC503.53162038
Sodium-dependent noradrenaline transporter Homo sapiens (human)IC508.595011
Sodium-dependent noradrenaline transporter Homo sapiens (human)Ki8.524011
Sodium-dependent serotonin transporterHomo sapiens (human)IC506.053011
Sodium-dependent serotonin transporterHomo sapiens (human)Ki3.216011
Solute carrier family 22 member 3Homo sapiens (human)Ki0.120011
Solute carrier organic anion transporter family member 1A3Rattus norvegicus (Norway rat)Ki0.500011
steroidogenic factor 1Homo sapiens (human)IC5067.568011
Substance-K receptorCavia porcellus (domestic guinea pig)IC50100.000011
Substance-P receptorCavia porcellus (domestic guinea pig)IC50100.000011
Thymidylate kinaseMycobacterium tuberculosis H37RvKi521.000011
Trypanothione reductaseTrypanosoma cruziKi38.000011
Tubulin alpha-1A chainHomo sapiens (human)IC5022.88383939
Tubulin alpha-1A chainSus scrofa (pig)IC504.67592828
Tubulin alpha-1A chainHomo sapiens (human)Ki2.400011
Tubulin alpha-1A chainSus scrofa (pig)Ki5.750011
Tubulin alpha-1B chainHomo sapiens (human)IC5022.88383939
Tubulin alpha-1B chainHomo sapiens (human)Ki2.400011
Tubulin alpha-1C chainHomo sapiens (human)IC5022.88383939
Tubulin alpha-1C chainHomo sapiens (human)Ki2.400011
Tubulin alpha-3C chainHomo sapiens (human)IC5022.88383939
Tubulin alpha-3C chainHomo sapiens (human)Ki2.400011
Tubulin alpha-3E chainHomo sapiens (human)IC5022.88383939
Tubulin alpha-3E chainHomo sapiens (human)Ki2.400011
Tubulin alpha-4A chainHomo sapiens (human)IC5022.88383939
Tubulin alpha-4A chainHomo sapiens (human)Ki2.400011
Tubulin beta chainHomo sapiens (human)IC5021.70714242
Tubulin beta chainSus scrofa (pig)IC504.84452626
Tubulin beta chainHomo sapiens (human)Ki2.400011
Tubulin beta chainSus scrofa (pig)Ki5.750011
Tubulin beta-1 chainHomo sapiens (human)IC5022.88383939
Tubulin beta-1 chainHomo sapiens (human)Ki2.400011
Tubulin beta-2A chainHomo sapiens (human)IC5022.88383939
Tubulin beta-2A chainHomo sapiens (human)Ki2.400011
Tubulin beta-2B chainBos taurus (cattle)IC50469.72332424
Tubulin beta-2B chainHomo sapiens (human)IC5022.88383939
Tubulin beta-2B chainBos taurus (cattle)Ki0.780011
Tubulin beta-2B chainHomo sapiens (human)Ki2.400011
Tubulin beta-3 chainHomo sapiens (human)IC5022.88383939
Tubulin beta-3 chainHomo sapiens (human)Ki2.400011
Tubulin beta-4A chainHomo sapiens (human)IC5022.88383939
Tubulin beta-4A chainHomo sapiens (human)Ki2.400011
Tubulin beta-4B chainHomo sapiens (human)IC5022.88383939
Tubulin beta-4B chainHomo sapiens (human)Ki2.400011
Tubulin beta-6 chainHomo sapiens (human)IC5022.88383939
Tubulin beta-6 chainHomo sapiens (human)Ki2.400011
Tubulin beta-8 chainHomo sapiens (human)IC5022.88383939
Tubulin beta-8 chainHomo sapiens (human)Ki2.400011
Vesicular acetylcholine transporterTetronarce californica (Pacific electric ray)IC502.620011
Xanthine dehydrogenase/oxidaseHomo sapiens (human)IC50200.000011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Adenosine receptor A1Homo sapiens (human)Kd45.000011
Adenosine receptor A2aHomo sapiens (human)Kd15.314422
Chain A, Glycogen phosphorylase, liver formHomo sapiens (human)Kd100.000018
DNA-(apurinic or apyrimidinic site) endonucleaseHomo sapiens (human)Kd0.049512
HeparanaseHomo sapiens (human)Kd1,000.000011
ORF73Human gammaherpesvirus 8EC5075.000012
Palmitoleoyl-protein carboxylesterase NOTUMHomo sapiens (human)EC5045.800011
Palmitoleoyl-protein carboxylesterase NOTUMHomo sapiens (human)Kd85.000011
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidaseHomo sapiens (human)Kd88.500011
Potassium channel subfamily K member 2Homo sapiens (human)EC50377.000011
Tubulin alpha-1A chainHomo sapiens (human)EC500.200011
Tubulin alpha-1A chainHomo sapiens (human)Kd5.679022
Tubulin alpha-1A chainSus scrofa (pig)Kd7.500022
Tubulin alpha-1B chainHomo sapiens (human)EC500.200011
Tubulin alpha-1B chainHomo sapiens (human)Kd5.679022
Tubulin alpha-1C chainHomo sapiens (human)EC500.200011
Tubulin alpha-1C chainHomo sapiens (human)Kd5.679022
Tubulin alpha-3C chainHomo sapiens (human)EC500.200011
Tubulin alpha-3C chainHomo sapiens (human)Kd5.679022
Tubulin alpha-3E chainHomo sapiens (human)EC500.200011
Tubulin alpha-3E chainHomo sapiens (human)Kd5.679022
Tubulin alpha-4A chainHomo sapiens (human)EC500.200011
Tubulin alpha-4A chainHomo sapiens (human)Kd5.679022
Tubulin beta chainHomo sapiens (human)EC500.200011
Tubulin beta chainHomo sapiens (human)Kd5.679022
Tubulin beta chainSus scrofa (pig)Kd7.500022
Tubulin beta-1 chainHomo sapiens (human)EC500.200011
Tubulin beta-1 chainHomo sapiens (human)Kd5.679022
Tubulin beta-2A chainHomo sapiens (human)EC500.200011
Tubulin beta-2A chainHomo sapiens (human)Kd5.679022
Tubulin beta-2B chainHomo sapiens (human)EC500.200011
Tubulin beta-2B chainHomo sapiens (human)Kd5.679022
Tubulin beta-3 chainHomo sapiens (human)EC500.200011
Tubulin beta-3 chainHomo sapiens (human)Kd5.679022
Tubulin beta-4A chainHomo sapiens (human)EC500.200011
Tubulin beta-4A chainHomo sapiens (human)Kd5.679022
Tubulin beta-4B chainHomo sapiens (human)EC500.200011
Tubulin beta-4B chainHomo sapiens (human)Kd5.679022
Tubulin beta-6 chainHomo sapiens (human)EC500.200011
Tubulin beta-6 chainHomo sapiens (human)Kd5.679022
Tubulin beta-8 chainHomo sapiens (human)EC500.200011
Tubulin beta-8 chainHomo sapiens (human)Kd5.679022
Tubulin polymerization-promoting proteinBos taurus (cattle)EC500.750011

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
5-hydroxytryptamine receptor 2CRattus norvegicus (Norway rat)ID500.040011
Adenosine receptor A1Homo sapiens (human)Affinity constant30.000011
Adenosine receptor A1Rattus norvegicus (Norway rat)Kb60.000014
Adenosine receptor A1Homo sapiens (human)KD hydro150,000.000011
Adenosine receptor A2aHomo sapiens (human)Affinity constant30.000011
Adenosine receptor A2aRattus norvegicus (Norway rat)Kb36.000011
Adenosine receptor A2aRattus norvegicus (Norway rat)Ratio48.000012
Adenosine receptor A2bHomo sapiens (human)Affinity constant30.000011
Adenosine receptor A2bMus musculus (house mouse)Kb25.000011
Adenosine receptor A2bRattus norvegicus (Norway rat)Ratio48.000012
Adenylate cyclase type 1Homo sapiens (human)Kb30.000011
ATP-dependent translocase ABCB1Homo sapiens (human)Km18.776723
Dihydrofolate reductaseLacticaseibacillus caseiID500.027011
Dihydrofolate reductaseMus musculus (house mouse)ID500.021122
DNA repair and recombination protein RAD54-like isoform 1Homo sapiens (human)AC506.950011
DNA repair protein RAD52 homolog isoform aHomo sapiens (human)AC509.330011
Folylpolyglutamate synthase, mitochondrialHomo sapiens (human)Km4.25911111
Folylpolyglutamate synthase, mitochondrialMus musculus (house mouse)Km8,800,010.000022
Folylpolyglutamate synthase, mitochondrialHomo sapiens (human)Vmax1.000011
Methylated-DNA--protein-cysteine methyltransferaseHomo sapiens (human)ED50235.000022
Muscarinic acetylcholine receptorCavia porcellus (domestic guinea pig)Kb25.000011
PAX8Homo sapiens (human)AC500.260011
Plasma kallikreinHomo sapiens (human)Activity1.060011
Tubulin alpha-1A chainHomo sapiens (human)Activity9.473399
Tubulin alpha-1B chainHomo sapiens (human)Activity9.473399
Tubulin alpha-1C chainHomo sapiens (human)Activity9.473399
Tubulin alpha-3C chainHomo sapiens (human)Activity9.473399
Tubulin alpha-3E chainHomo sapiens (human)Activity9.473399
Tubulin alpha-4A chainHomo sapiens (human)Activity9.473399
Tubulin beta chainHomo sapiens (human)Activity9.473399
Tubulin beta-1 chainHomo sapiens (human)Activity9.473399
Tubulin beta-2A chainHomo sapiens (human)Activity9.473399
Tubulin beta-2B chainHomo sapiens (human)Activity9.473399
Tubulin beta-3 chainHomo sapiens (human)Activity9.473399
Tubulin beta-4A chainHomo sapiens (human)Activity9.473399
Tubulin beta-4B chainHomo sapiens (human)Activity9.473399
Tubulin beta-6 chainHomo sapiens (human)Activity9.473399
Tubulin beta-8 chainHomo sapiens (human)Activity9.473399
Vasopressin V2 receptorSus scrofa (pig)Kb30.000011