| "Cocaine abuse is associated with heightened risk of life-threatening neurological complications such as strokes, seizures, and transient ischemic attacks." | ( Better, W; Cadet, JL; Gorelick, D; Herning, RI; Nelson, R, 1999) |
| "Thus, maternal cocaine abuse is associated with thickening of the interlobular arterial wall of the fetal kidney and narrowing of the lumen." | ( Gil, J; Mitra, SC; Salcedo, JR; Seshan, SV, 2000) |
| "Cocaine addiction is thought to stem, in part, from neural adaptations that act to maintain equilibrium by countering the effects of repeated drug administration." | ( Bibb, JA; Chen, J; Greengard, P; Nairn, AC; Nestler, EJ; Nishi, A; Ouimet, CC; Sagawa, ZK; Snyder, GL; Svenningsson, P; Taylor, JR; Yan, Z, 2001) |
| "Treatment of cocaine addiction is hampered by high rates of relapse even after prolonged drug abstinence." | ( Crombag, H; De Vries, TJ; Dieben, J; Homberg, JR; Schoffelmeer, AN; Schuurman, K; Shaham, Y; Vanderschuren, LJ, 2001) |
| "Cocaine dependence is a common and serious condition, which has become nowadays a substantial public health problem." | ( Farrell, M; Lima, MS; Reisser, AA; Soares, BG, 2001) |
| "Cocaine addiction is rapidly progressive and associated with severe medical, psychiatric, and psychosocial consequences." | ( Dackis, CA; O'Brien, CP, 2001) |
| "Cocaine addiction is a chronically relapsing brain disease, but its neural basis is not yet well understood." | ( Black, Y; Eichenbaum, HB; Green-Jordan, K; Kantak, KM; Valencia, E, 2002) |
| "Cocaine abuse is increasing, particularly among young people." | ( Brownlow, HA; Pappachan, J, 2002) |
| "Cocaine dependence is a common and serious condition, associated with severe medical, psychological and social problems, including the spread of infectious diseases." | ( de Lima, MS; de Oliveira Soares, BG; Farrell, M; Reisser, AA, 2002) |
| "Cocaine addiction is thought to involve persistent neurobiological changes that facilitate relapse to drug use despite efforts to abstain." | ( Choi, KH; Karanian, DA; Monteggia, LM; Neve, RL; Schad, CA; Schmidt, EF; Self, DW; Simmons, D; Sutton, MA; Whisler, K, 2003) |
| "Cocaine dependence is a common and serious condition, which has become nowadays a substantial public health problem." | ( Farrell, M; Lima, MS; Reisser, AA; Soares, BG, 2003) |
| "Its efficacy for cocaine dependence is uncertain." | ( Cheskin, LJ; Contoreggi, C; Fudala, PJ; Gorelick, DA; Johnson, RE; Lange, WR; Montoya, ID; Preston, KL; Schroeder, JR; Umbricht, A, 2004) |
| "Cocaine addiction is a disease that develops over time, and it is thought that drug-induced neuro-adaptations underlie the changes in behavior seen across the addictive process." | ( Hamby, SM; McCracken, CB; Morgan, D; Patel, KM; Roberts, DC; Vrana, KE, 2005) |
| "Cocaine abuse is a serious and socially damaging illegal drug problem." | ( Breen, G; Guindalini, C; Laranjeira, R; Vallada, H, 2006) |
| "Cocaine dependence is associated with high rates of relapse." | ( Garcia, M; Kreek, MJ; Paliwal, P; Rounsaville, BJ; Sinha, R, 2006) |
| "Cocaine dependence is a major public health problem for which there is no FDA-approved pharmacological treatment." | ( Boardman, K; Chiang, N; Collins, J; Elkashef, A; Fudala, PJ; Gorgon, L; Jones, K; Kahn, R; Li, SH; Sather, M; Vocci, F, 2006) |
| "Cocaine addiction is a major health and social problem for which there are presently no effective pharmacotherapies." | ( Haile, CN; Kosten, TA; Kosten, TR, 2007) |
| "Cocaine dependence is associated with an increased risk of infectious diseases." | ( Butch, A; Cole, SW; Fong, T; Irwin, MR; Motivala, SJ; Newton, T; Olmos, L; Olmstead, R; Valladares, EM; Wang, M, 2007) |
| "Cocaine abuse is associated with cerebrovascular events; spinal cord effects are rarely reported." | ( Formal, CS; Schreiber, AL, 2007) |
| "Cocaine addiction is a significant worldwide public health problem, associated with somatic, psychological, psychiatric, socioeconomic and legal complications." | ( Benyamina, A; Coscas, S; Cottencin, O; Ferreri, M; Karila, L; Reynaud, M, 2007) |
| "Cocaine dependence is associated with impairment of dopamine function, and this impairment appears to play a critical role in relapse." | ( Broft, A; Cooper, TB; Fischman, MW; Foltin, RW; Huang, Y; Hwang, DR; Kleber, HD; Laruelle, M; Martinez, D; Narendran, R; Slifstein, M, 2007) |
| "Cocaine addiction is one of the severest health problems faced by western countries, where there is an increasing prevalence of lifelong abuse." | ( Casas, M; Castells, X; Corominas, M; Ribases, M; Roncero, C, 2007) |
| "Cocaine dependence is a public health problem characterized by recidivism and a host of medical and psychosocial complications." | ( Amato, L; Davoli, M; Minozzi, S; Pani, PP, 2007) |
| "Cocaine dependence is associated with an enhanced sensitivity to stress and drug craving." | ( Bergquist, KT; Fox, H; Hong, KI; Morgan, PT; Sinha, R; Sofuoglu, M, 2007) |
| "Interruption of cocaine abuse is the cornerstone of secondary prevention in cocaine-related myocardial infarction." | ( Kloner, RA; Rezkalla, SH, 2007) |
| "Cocaine dependence is quite serious and is associated with numerous adverse health consequences." | ( Aubin, HJ; Benyamina, A; Coscas, S; Karila, L; Lépine, JP; Leroy, C; Lowenstein, W; Noble, F; Reynaud, M; Weinstein, A, 2008) |
| "Cocaine addiction is a relapsing psychiatric disorder with a high prevalence in developed countries." | ( Barbano, MF; Maldonado, R; Soria, G; Valverde, O, 2008) |
| "Cocaine addiction is known to impair immune system function, but the effects of repeated treatment with cocaine in a self-administration model, its withdrawal as well as reinstatement of cocaine-seeking behavior on cell-mediated immunity are not well known." | ( Basta-Kaim, A; Budziszewska, B; Filip, M; Jaworska-Feil, L; Kubera, M; Lason, W; Leskiewicz, M; Machowska, A; Przegalinski, E; Regulska, M; Wydra, K, 2008) |
| "Cocaine addiction is associated with an increase in actin cycling and alterations in dendritic spines in the nucleus accumbens." | ( Kalivas, PW; Pacchioni, AM; Wiggins, AT, 2009) |
| "Cocaine addiction is characterized by an impaired ability to develop adaptive behaviors that can compete with cocaine seeking, implying a deficit in the ability to induce plasticity in cortico-accumbens circuitry crucial for regulating motivated behavior." | ( Gass, JT; Kalivas, PW; Lavin, A; Moran, M; Moussawi, K; Olive, MF; Pacchioni, A, 2009) |
| "Cocaine dependence is characterized by stress system dysregulation, including elevated cortisol activity, emotional negativity, and behavioral disinhibition." | ( Fox, HC; Jackson, ED; Sinha, R, 2009) |
| "Cocaine dependence is a major public health problem for which there is no FDA-approved pharmacological treatment." | ( Alathari, H; Beresford, T; Biswas, K; Chiang, N; Childress, AR; Collins, J; Elkashef, A; Fudala, PJ; Gorgon, L; Gruber, V; Kahn, R; Li, SH; Liberto, J; McSherry, F; Montoya, I; Shoptaw, S; Stock, C; Wallace, C; Watson, D, 2009) |
| "Cocaine addiction is a worldwide public health problem for which there are no established treatments." | ( Caine, SB; Gu, HH; Han, DD; Thomsen, M, 2009) |
| "Cocaine addiction is a chronic relapsing disorder associated with severe medical and psychosocial complications." | ( Cepeda, S; Knecht, C; Martínez-Raga, J, 2008) |
| "Cocaine dependence is associated with severe medical, psychiatric, and social morbidity, but no pharmacotherapy is approved for its treatment in the United States." | ( Brodie, JD; Case, BG; Dewey, SL; Figueroa, E; Laska, EM; Robinson, JA; Wanderling, JA, 2009) |
| "Cocaine abuse is a significant problem among pregnant women." | ( Xiao, D; Yang, S; Zhang, L, 2009) |
| "Cocaine addiction is characterized as a chronically relapsing disorder." | ( Barker, DJ; Fabbricatore, AT; Ma, S; Pawlak, AP; Root, DH; West, MO, 2009) |
| "Cocaine dependence is a disorder for which no pharmacological treatment of proven efficacy exists, advances in the neurobiology could guide future medication development." | ( Amato, L; Davoli, M; Pani, PP; Trogu, E; Vacca, R; Vecchi, S, 2010) |
| "Cocaine addiction is an important public health problem worldwide, and use of this drug is growing in France." | ( Haas, C; Karila, L; Lowenstein, W, 2009) |
| "Cocaine dependence is a common and serious condition, which has become a substantial public health problem." | ( Farrell, M; Lima Reisser, AA; Silva de Lima, M; Soares, B, 2010) |
| "Maternal cocaine addiction is a significant public health issue particularly affecting children, with high rates of reported abuse, neglect, and foster care placement." | ( Mayes, LC; Strathearn, L, 2010) |
| "Cocaine addiction is characterized by a gradual loss of control over drug use, but the molecular mechanisms regulating vulnerability to this process remain unclear." | ( Amelio, AL; Bali, P; Conkright, MD; Hollander, JA; Im, HI; Kenny, PJ; Kocerha, J; Lu, Q; Wahlestedt, C; Willoughby, D, 2010) |
| "Cocaine abuse is now a major health hazard: more than 5 million of Americans are current users." | ( Alessandri, N; D'Ambrosi, A; Di Matteo, A; Fusco, L; Lanzi, L; Petrassi, M; Tufano, F, 2010) |
| "Cocaine addiction is commonly viewed as a disorder of neuroplasticity, but the potential involvement of MeCP2 has not been explored." | ( Bali, P; Hollander, JA; Im, HI; Kenny, PJ, 2010) |
| "Cocaine abuse is on the rise and it brings the challenges to treat the complication associated with it, particularly cardiovascular complications." | ( Arora, RR; Bhargava, S, 2011) |
| "Cocaine addiction is characterized by a persistently heightened susceptibility to drug relapse." | ( Baker, DA; Bohr, C; Figueroa-Guzman, Y; Graf, EN; Li, SJ; Mantsch, JR; Mueller, C; Vranjkovic, O; Wisniewski, S; Yang, Z, 2011) |
| "Cocaine dependence is characterized by compulsive drug seeking and high vulnerability to relapse." | ( Amore, M; Ciccocioppo, R; Donnini, C; Gerra, G; Gerra, ML; Kalluppi, M; Malagoli, M; Raggi, MA; Saracino, MA; Somaini, L, 2011) |
| "Cocaine addiction is associated with either ischaemic or non-ischaemic cardiac complications." | ( Aquaro, GD; Emdin, M; Gabutti, A; Lombardi, M; Meini, M; Pasanisi, E; Passino, C; Prontera, C, 2011) |
| "Cocaine addiction is often modeled in experimental paradigms where rodents learn to self-administer (SA) the drug." | ( Agosta, F; Bifone, A; Corsi, M; Cristofori, P; Dacome, L; Gozzi, A; Lanzoni, A; Lepore, S; Pich, EM; Tessari, M, 2011) |
| "Cocaine dependence is associated with orbitofrontal cortex (OFC)-dependent cognitive inflexibility in both humans and laboratory animals." | ( Homberg, JR; Maes, JH; Nonkes, LJ, 2013) |
| "Cocaine addiction is a major health problem that affects millions of people." | ( Homberg, JR; Nonkes, LJ; van Bussel, IP; Verheij, MM, 2011) |
| "Cocaine dependence is a public health concern and cause of significant morbidity and mortality worldwide." | ( Kosten, TR; Shorter, D, 2011) |
| "Cocaine dependence is associated with high rates of sexual risk behavior and HIV infection." | ( Bruner, NR; Johnson, MW, 2012) |
| "Adulterated cocaine abuse is an increasingly recognized phenomenon in North America." | ( Cuchacovich, R; Espinoza, LR; Garcia-Valladares, I; Khan, TA; Lata, S; Patel, NJ; Salassi, MM; Sanders, CV, 2011) |
| "Cocaine dependence is a pervasive disorder with high rates of relapse." | ( Anker, JJ; Brimijoin, S; Carroll, ME; Gao, Y; Geng, L; Parks, RJ; Zlebnik, NE, 2012) |
| "Cocaine dependence is associated with increased stress and drug cue-induced craving and physiological arousal but decreased prefrontal activity to emotional and cognitive challenge." | ( Fox, HC; Hansen, J; Kimmerling, A; Morgan, PT; Seo, D; Sinha, R; Tuit, K, 2012) |
| "Cocaine addiction is characterized by compulsive drug seeking, including relapse after a period of withdrawal." | ( Fischer-Smith, KD; Houston, AC; Rebec, GV, 2012) |
| "Cocaine addiction is associated with high rates of relapse, and stress has been identified as a major risk factor." | ( Choi, SM; Jang, EY; Kim, HY; Lee, BH; Steffensen, SC; Yang, CH; Yang, EJ; Yoon, SS, 2012) |
| "Cocaine addiction is a major problem affecting all societal and economic classes for which there is no effective therapy." | ( Crystal, RG; De, BP; Frenk, E; Hackett, NR; Hicks, MJ; Janda, KD; Kaminsky, SM; Koob, GF; Mezey, JG; Pagovich, O; Rosenberg, JB; Tignor, N; Wee, S; Worgall, S, 2012) |
| "Cocaine addiction is a significant and complex disease." | ( Allen, RM; Gomez, E; Johnston, NL; Mandt, BH; Zahniser, NR, 2012) |
| "Cocaine dependence is a chronically relapsing disorder for which its predominant behavioral therapies are associated with only partial efficacy." | ( Drexler, KP; Gross, RE; Kennedy, AP; Kilts, CD; Whitfield, N, 2012) |
| "Cocaine addiction is characterized by impulsivity, impaired social relationships, and abnormal mesocorticolimbic reward processing, but their interrelationships relative to stages of cocaine addiction are unclear." | ( Andrews, MM; Assaf, M; Hyatt, CJ; Hylton, JL; Johnson, MR; Krystal, JH; Muska, CE; Pearlson, GD; Potenza, MN; Reynolds, BA; Rosen, RI; Thomas, AD, 2012) |
| "Cocaine dependence is a significant public health problem for which there are currently no FDA-approved medications." | ( Adinoff, B; Brady, KT; Brigham, G; Kropp, F; Lindblad, R; Liu, D; Sharma, G; Somoza, E; Sparenborg, S; Stitzer, M; Vanveldhuisen, P; Winhusen, T; Woody, G, 2012) |
| "Cocaine dependence is a substantial public health problem, yet there are no clearly effective medication treatments." | ( Bisaga, A; Brooks, DJ; Levin, FR; Mariani, JJ; Nunes, EV; Pavlicova, M, 2012) |
| "Cocaine addiction is a worldwide public health problem, which has somatic, psychological, psychiatric, socio-economic and judicial complications." | ( Karila, L; Lowenstein, W; Petit, A; Reynaud, M, 2012) |
| "Cocaine abuse is widespread all over the world, and is performed generally by sniffing, injecting or smoking cocaine or crack." | ( Anzillotti, L; Bermejo, AM; Chiarotti, M; Rubio, C; Strano-Rossi, S; Tabernero, MJ, 2013) |
| "Cocaine dependence is a significant public health problem, characterized by periods of abstinence." | ( Benturquia, N; Noble, F; Puig, S, 2012) |
| "Cocaine addiction is a chronic relapsing disease with periods of chronic escalating self-exposure, separated by periods of abstinence/withdrawal of varying duration." | ( Butelman, ER; Ho, A; Kreek, MJ; Rabkin, J; Schlussman, SD; Zhang, Y, 2013) |
| "Cocaine addiction is a behavioral disorder defined by behavioral symptoms that set it apart from nondisordered forms of drug use." | ( Ahmed, SH; Kenny, PJ, 2011) |
| "Cocaine addiction is characterized by long-lasting vulnerability to relapse arising because neutral environmental stimuli become associated with drug use and then act as cues that induce relapse." | ( Gipson, CD; Kalivas, PW; Kupchik, YM; Reissner, KJ; Shen, H; Thomas, CA, 2013) |
| "Cocaine dependence is a significant public health problem, yet no validated pharmacological treatment exists." | ( Bickel, WK; Ciraulo, DA; Galloway, GP; Gorodetzky, CW; Jasinski, D; Lewis, D; Miller, SR; Roache, JD; Segal, SD; Sheehan, M; Somoza, EC; Somoza, P; Watson, DW; Winhusen, T; Winship, D, 2013) |
| "Cocaine addiction is a chronic, relapsing disease characterized by an inability to regulate drug-seeking behavior." | ( Knackstedt, LA; Schwendt, M; Trantham-Davidson, HL, 2014) |
| "Cocaine addiction is associated with altered resting-state functional connectivity among regions of the mesocorticolimbic dopamine pathways." | ( Goldstein, RZ; Konova, AB; Moeller, SJ; Tomasi, D; Volkow, ND, 2013) |
| "Cocaine addiction is driven by genetic, neurologic and environmental components." | ( Edusei, E; Ho, A; Kreek, MJ; Lawhorn, C; Zhou, Y, 2013) |
| "Cocaine abuse is a major public health problem with multiple-related complications." | ( Barcia, JM; Genovés, JM; López-Pedrajas, R; Miranda, M; Muriach, M; Romero, FJ; Sánchez-Vallejo, V; Sánchez-Villarejo, MV, 2014) |
| "Cocaine abuse is associated with various skin and rheumatological diseases that mimic primary autoimmune diseases, including retiform purpura with involvement of the ears, cocaine-induced midline destructive lesions (CIMDL), and eruptive pyoderma gangrenosum (PG)." | ( Albarrán-Planelles, C; Bravo-Monge, R; García-Moreno, E; Jiménez-Gallo, D; Linares-Barrios, M; Martínez-Rodríguez, A; Rodríguez-Hernández, C, 2013) |
| "Cocaine dependence is characterized by compulsive drug taking that supercedes other recreational, occupational or social pursuits." | ( Becker, JB; Perry, AN; Westenbroek, C, 2013) |
| "Cocaine dependence is a major public health problem with no available robustly effective pharmacotherapy." | ( Cargile, C; Chopra, MP; Guise, JB; Kosten, TR; Mancino, MJ; McGaugh, J; Oliveto, A; Sanders, N; Thostenson, J; Williams, DK, 2014) |
| "Crack-cocaine dependence is a complex disorder with limited treatment options." | ( Blanken, P; Hendriks, V; Nuijten, M; van den Brink, W, 2014) |
| "Cocaine abuse is not only associated with central necrotizing vasculitis, but it is also appeared to play a role in the development of peripheral vasoconstriction with symptoms similar to Buerger's disease." | ( Ameri, P; Denegri, A; Murialdo, G; Paparo, F, 2016) |
| "Cocaine addiction is characterized by deficits in inhibitory control and elevated reactivity to cocaine cues, both hypothesized to be integral to development of addiction and propensity to relapse." | ( Bell, RP; Foxe, JJ; Garavan, H, 2014) |
| "Cocaine addiction is characterized by alternating cycles of abstinence and relapse and loss of control of drug use despite severe negative life consequences associated with its abuse." | ( Daunais, JB; Gopinath, KS; Howell, LL; Maltbie, E; Murnane, KS; Telesford, QK, 2015) |
| "Cocaine abuse is associated with cardiovascular complications that include chest pain and myocardial infarction." | ( Belchikov, Y; Gitman, B; Schurr, JW, 2014) |
| "Cocaine addiction is a chronically relapsing disorder that is associated with harmful consequences." | ( Baumgartner, MR; Henning, A; Herdener, M; Hulka, LM; Preller, KH; Quednow, BB; Scheidegger, M; Seifritz, E; Vonmoos, M, 2016) |
| "The treatment of cocaine dependence is difficult as no approved pharmacotherapy is available as yet." | ( Grosshans, M; Kiefer, F; Mutschler, J, 2015) |
| "Cocaine abuse is common among HIV infected individuals, and this abuse augments HIV-associated neurological deficits." | ( Chen, L; Napier, TC; Persons, AL; Wayman, WN, 2015) |
| "Crack-cocaine dependence is a serious disorder with no approved pharmacological treatment." | ( Blanken, P; Hendriks, V; Nuijten, M; van den Brink, W, 2015) |
| "Cocaine abuse is associated with several mechanisms of brain injury including ischemic, hemorrhagic and metabolic." | ( Schmidt, BJ; Vosoughi, R, 2015) |
| "Cocaine addiction is a major public health problem with a substantial genetic basis for which the biological mechanisms remain largely unknown." | ( Bubier, JA; Calton, MA; Chesler, EJ; Cook, MN; Dickson, PE; Goldowitz, D; Miller, MM; Mittleman, G, 2016) |
| "Cocaine addiction is characterized by alterations in motivational and cognitive processes." | ( Ávila, C; Barrós-Loscertales, A; Bustamante, JC; Costumero, V; Fuentes, P; Llopis, JJ; Rosell-Negre, P, 2017) |
| "Cocaine abuse is a world-wide public health and social problem without a US Food and Drug Administration-approved medication." | ( Chen, X; Hou, S; Jin, Z; Xue, L; Zhan, CG; Zhang, T; Zheng, F, 2016) |
| "Cocaine dependence is a difficult-to-treat, chronically relapsing disorder." | ( Bickel, WK; Hanlon, CA; Quisenberry, AJ; Snider, SE; Stein, JS, 2016) |
| "Cocaine abuse is a major worldwide health problem." | ( Albertson, TE; Amsterdam, EA; Derlet, RW; Garber, D; Lange, RA; Laurin, EG; Olson, KR; Ramoska, EA; Richards, JR, 2016) |
| "Crack-cocaine addiction is associated with a variety of conditions that increase risk of thiamine deficiency and Wernicke's encephalopathy." | ( Castro, M; Diemen, LV; Escobar, M; Kessler, FH; Sukop, PH; Valerio, AG, 2016) |
| "Cocaine dependence is a public health problem characterised by recidivism and a host of medical and psychosocial complications." | ( Amato, L; Indave, BI; Minozzi, S; Pani, PP, 2016) |
| "Although cocaine abuse is up to three times more frequent among schizophrenic patients, it remains unclear why this should be the case and whether sex influences this relationship." | ( Ambrosio, E; Borcel, É; Capellán, R; Higuera-Matas, A; Orihuel, J; Roura-Martínez, D; Santos-Toscano, R; Ucha, M, 2016) |
| "Cocaine addiction is a chronic brain disease in which the drug seeking habits and profound cognitive, emotional and motivational alterations emerge from drug-induced neuroadaptations on a vulnerable brain." | ( Araos, P; Blanco, E; Castilla-Ortega, E; Pavón, FJ; Rodríguez de Fonseca, F; Santín, LJ; Serrano, A; Suárez, J, 2016) |
| "Cocaine addiction is a major public health problem that is particularly difficult to treat." | ( Bullmore, ET; de Wit, S; Ersche, KD; Gillan, CM; Jones, PS; Luijten, M; Robbins, TW; Sahakian, BJ; Ward, LH; Williams, GB, 2016) |
| "Cocaine addiction is often characterized by a rigid pattern of behavior in which cocaine users continue seeking and taking drug despite negative consequences associated with its use." | ( Berini, CR; Ghee, SM; Leong, KC; Reichel, CM, 2016) |
| "Cocaine abuse is a significant health problem worldwide." | ( Borislav, M; Kiryakova, T; Manolov, V; Petrova, J; Radoslava, E; Tzatchev, K; Vasilev, V, 2016) |
| "Cocaine addiction is a debilitating neuropsychiatric disorder characterized by uncontrolled cocaine intake, which is thought to be driven, at least in part, by cocaine-induced deficits in dopamine system function." | ( Fordahl, SC; Jones, SR; Siciliano, CA, 2016) |
| "Cocaine addiction is a disease characterized by chronic relapse despite long periods of abstinence." | ( Arguello, AA; Fuchs, RA; Hall, JL; Hodges, MA; Mitchell, MP; Richardson, BD; Rossi, DJ; Stuber, GD; Wang, R, 2017) |
| "Cocaine addiction is a chronic relapsing disorder that is difficult to treat in part because addicts relapse even after extended periods of abstinence." | ( Cameron, CM; Carelli, RM; Wightman, RM, 2016) |
| "Cocaine addiction is a chronic relapsing disorder characterized by the loss of control over drug-seeking and taking, and continued drug use regardless of adverse consequences." | ( Batuecas, J; Cuesta, S; Funes, A; Pacchioni, AM; Rosso, SB; Severin, MJ, 2017) |
| "Cocaine addiction is a chronic brain disease affecting neurotransmission." | ( Conn, PJ; Dall, C; Dencker, D; Fink-Jensen, A; Molander, AC; Thomsen, M; Weikop, P; Wörtwein, G, 2017) |
| "Cocaine addiction is a chronic psychiatric disorder characterized by pathological motivation to obtain cocaine and behavioral and neurochemical hypersensitivity to cocaine-associated cues." | ( Brodnik, ZD; España, RA; Levy, KA; Perrey, DA; Shaw, JK; Zhang, Y, 2017) |
| "Cocaine abuse is a major public health issue due to its role in the HIV and hepatitis C virus (HCV) epidemics in North America." | ( Arruda, N; Bertrand, K; Jutras-Aswad, D; Motta-Ochoa, R; Roy, É, 2017) |
| "Crack-cocaine addiction is an important public health problem worldwide." | ( Almeida, PP; Bressan, RA; de Araujo Filho, GM; Lacerda, ALT; Laranjeira, RR; Malta, SM; Marques, ACRP, 2017) |
| "Cocaine addiction is thought to be the result of drug-induced functional changes in a neural network implicated in emotions, learning and cognitive control." | ( Gao, P; Groenewegen, HJ; Vanderschuren, LJMJ; Voorn, P, 2018) |
| "Cocaine addiction is characterized by the continued use despite the dire consequences, and the deficit in inhibitory control may play a key role in this process." | ( Datta, U; Martini, M; Sun, W, 2018) |
| "Cocaine addiction is characterized by dysfunction in reward-related brain circuits, leading to maladaptive motivation to seek and take the drug." | ( Calipari, ES; Godino, A; Hurd, YL; Kiraly, DD; Landry, JA; Mervosh, NL; Nestler, EJ; Peck, EG; Russo, SJ; Salery, M, 2018) |
| "Cocaine addiction is a disorder that still lacks diagnostic biomarkers or effective pharmacotherapy." | ( Bormans, G; Casteels, C; de Laat, B; Himmelreich, U; Leurquin-Sterk, G; Van Laere, K; Weerasekera, A, 2018) |
| "Cocaine abuse is a problem of current interest, which is mostly hidden and underdiagnosed, but dramatically widespread among all socio-economic strata, and with an incidence which is increasing at an alarming rate." | ( Antoñanzas, J; España, A; Moreno-Artero, E; Pilar Gil-Sánchez, M; Querol-Cisneros, E; Rodríguez-Garijo, N; Secundino, F; Tomás-Velázquez, A, 2018) |
| "Cocaine addiction is related to impulsive decision making that is mediated by brain circuitry involved in reward processing and executive functions, such as cognitive control and attentional salience." | ( Bell, RP; Hobkirk, AL; Huettel, S; Meade, CS; Utevsky, AV, 2019) |
| "Treating cocaine addiction is a major challenge and currently no FDA approved pharmacotherapies exist." | ( Bavley, CC; Rajadhyaksha, AM, 2019) |
| "Cocaine dependence is a disorder where relapses are frequently presented and many factors are involved." | ( Álvarez, AI; Casas, M; Daigre, C; Díaz-Morán, S; Grau-López, L; Palma-Álvarez, RF; Rodríguez-Cintas, L; Roncero, C; Ros-Cucurull, E, 2019) |
| "Cocaine addiction is a chronic disorder with high relapse rates; therefore, understanding the neuronal mechanisms underlying drug-seeking during relapse is a priority to develop targeted pharmacotherapy." | ( Arenas, MC; Manzanedo, C; Mateos-García, A; Miñarro, J, 2020) |
| "Cocaine addiction is a chronic relapsing brain disorder characterized by compulsive drug seeking." | ( Bu, Q; Cen, X; Guo, W; Long, H; Tian, J; Wang, H; Zhao, Y, 2020) |
| "Individuals with cocaine addiction are characterized by under-responsiveness to natural reinforcers." | ( Le, TM; Li, CR; Zhang, S; Zhornitsky, S, 2019) |
| "Cocaine addiction is characterized by alterations in motivational and cognitive processes involved in goal-directed behavior." | ( Barrós-Loscertales, A; Bustamante, JC; Costumero, V; Fuentes-Claramonte, P; Llopis-Llacer, JJ; Rosell-Negre, P, 2020) |
| "Vulnerability to cocaine addiction is associated with dysregulation of this signaling." | ( Caffino, L; Diniz, DM; Fumagalli, F; Homberg, JR; Mottarlini, F; Verheij, MM, 2019) |
| "Cocaine abuse is associated with substantial morbidity and mortality." | ( Kampman, KM, 2019) |
| "Cocaine addiction is a chronic, relapsing disorder." | ( Caccamise, A; Corbett, CM; Loweth, JA; Munshi, S; Rosenkranz, JA; Wolf, ME, 2021) |
| "Cocaine addiction is a chronic brain disease characterized by compulsive drug intake and dysregulation of brain reward systems." | ( Butelman, ER; Kreek, MJ; Reed, B; Valenza, M; Windisch, KA, 2020) |
| "Cocaine addiction is a chronic disorder in which the person loses control over drug use." | ( Ávila-Gámiz, F; Castilla-Ortega, E; Gil-Rodríguez, S; Mañas-Padilla, MC; Rodríguez de Fonseca, F; Sampedro-Piquero, P; Santín, LJ, 2021) |
| "Cocaine addiction is a chronic illness characterized by maladaptive drug-induced neuroplastic changes that confer lasting vulnerability to relapse." | ( Jensen, KL; Thomsen, M; Weikop, P, 2020) |
| "Cocaine addiction is characterized by overwhelming craving for the substance, which drives its escalating use despite adverse consequences." | ( Baumgartner, MR; Engeli, EJE; Esposito, F; Henning, A; Herdener, M; Hock, A; Hulka, LM; Kirschner, M; Nordt, C; Quednow, BB; Scheidegger, M; Seifritz, E; Zoelch, N, 2021) |
| "Cocaine addiction is a severe psychiatric condition for which currently no effective pharmacotherapy is available." | ( Barros, M; Filip, M; Frankowska, M; Gulbins, E; Jesus, FM; Kalinichenko, LS; Kornhuber, J; Maior, RS; Mühle, C; Müller, CP; Pacheco, JVN; Piechota, M; Sadakierska-Chudy, A; Smaga, I, 2021) |
| "Cocaine addiction is a chronic and relapsing disorder with an important genetic component." | ( Bellivier, F; Besson, M; Correia, C; Corringer, PJ; Forget, B; Gielen, M; Icick, R; Maskos, U; Prevost, MS; Robert, J; Vorspan, F, 2021) |
| "Cocaine addiction is a global health problem with no approved pharmacotherapies." | ( Chesworth, R; Karl, T, 2020) |
| "Cocaine addiction is a serious health issue in Western countries." | ( Acher, F; Befort, K; Bourdy, R; De Sa Nogueira, D; Filliol, D; McCort-Tranchepain, I; Quessada, C; Romieu, P; Zwiller, J, 2021) |
| "Cocaine dependence is an important problem without any effective pharmacological treatment." | ( Aguilar, MA; Calpe-López, C; Gasparyan, A; Manzanares, J; Miñarro, J; Navarrete, F, 2021) |
| "The incidence of cocaine abuse is increasing especially in the U." | ( Grad, E; Thornton, C; Yaka, R, 2021) |
| "Cocaine abuse is associated with severe local effects on mucosal and osteocartilaginous structures, with a centrifugal spreading pattern from the nose, a condition known as cocaine-induced midline destructive lesions (CIMDL)." | ( Bondi, S; Gastaldi, G; Policaro, NS; Rampi, A; Vinciguerra, A, 2021) |
| "Cocaine addiction is associated with altered sensitivity to natural reinforcers and intense drug craving." | ( Dhingra, I; Le, TM; Li, CR; Wang, W; Zhang, S; Zhornitsky, S, 2021) |
| "Cocaine addiction is a chronic relapsing disorder that lacks of an effective treatment." | ( Cabrera, R; de la Torre, R; Farre, M; Gutiérrez-Martos, M; Langohr, K; Maldonado, R; Martin, M, 2021) |
| "Crack-cocaine dependence is a serious public health issue, related to several psychiatric and psychosocial problems." | ( Fischer, B; Laranjeira, R; Oikawa, KF; Perrenoud, LO; Ribeiro, M; Strang, J; Williams, AV, 2021) |
| "Cocaine dependence is a highly prevalent disease in modern society and lacks an effective treatment." | ( Aguilar, MA; Ledesma, JC; Manzanedo, C, 2021) |
| "Cocaine addiction is a chronic, relapsing disorder characterized by maladaptation in the brain mesolimbic and nigrostriatal dopamine system." | ( Fayette, N; Ford, CP; Gong, S; Heinsbroek, JA, 2021) |
| "Cocaine addiction is a significant medical and public concern." | ( Alén, F; Bi, GH; Buck, T; Crissman, M; Galaj, E; Gardner, EL; Leggio, L; Moore, AR; Pari, S; Wang, B; Wise, RA; Xi, ZX; You, ZB, 2022) |
| "Cocaine addiction is a psychosocial disorder induced by the chronic use of cocaine and causes a large number of deaths around the world." | ( Chen, D; Ellsworth, E; Feng, H; Gao, K; Robison, AJ; Shen, L; Wei, GW, 2022) |
| "Cocaine abuse is widely increasing, especially in younger individuals." | ( Abrignani, MG; Amico, AF; Boschini, A; Caldarola, P; Ciccirillo, F; Cocozza, S; Colivicchi, F; Gabriele, M; Gabrielli, D; Giallauria, F; Grosseto, D; Gulizia, MM; Morici, N; Santucci, A, 2022) |
| "Cocaine addiction is a complex brain disorder involving long-term alterations that lead to loss of control over drug seeking." | ( Cabana-Domínguez, J; Cormand, B; Domingo-Rodriguez, L; Fernàndez-Castillo, N; Maldonado, R; Martín-García, E, 2022) |
| "Cocaine addiction is a serious condition with potentially lethal complications and no current pharmacological approaches towards treatment." | ( Andressoo, JO; Garton, DR; Iivanainen, V; Turconi, G, 2023) |
| "Cocaine abuse is a serious public health problem as this drug exerts a plethora of functional and histopathological changes that potentially lead to death." | ( Addobbati, R; Aleksova, A; Concato, M; D'Errico, S; Fluca, AL; Giacomello, E; Peruch, M; Radaelli, D, 2023) |