| Excerpt | Reference |
|---|
| "Since septic shock is characterized by lowered arterial pressure and vasodilatation it is concluded that effects of dopamine on capacitance and resistance vessels make this drug more suitable." | ( Carlet, J; Regnier, B; Safran, D; Teisseire, B, 1979) |
| "Septic shock is frequently associated with acute renal failure." | ( Ali, MM; Duarte, RR; Grace, BW; Nayak, P; Sayegh, NY, 1992) |
| "Septic shock is a major complication during the treatment of intense care patients." | ( Hartung, T; Tiegs, G; Wendel, A, 1992) |
| "Septic shock is a complex event with activation of many inflammatory pathways." | ( Weinberg, JR, 1992) |
| "Septic shock is an acute impairment of tissue perfusion, characterized by hypotension, low systemic vascular resistance and increased blood levels of lactate." | ( Ruokonen, E; Takala, J, 1992) |
| "Septic shock is characterized by hypoperfusion and tissue energy defects." | ( Astiz, M; Fried, J; Rackow, E; Tuchschmidt, J, 1992) |
| "Septic shock is characterized by a decreased vascular tone and a depressed myocardial function." | ( Cosyns, B; Moulart, D; Preiser, JC; Vincent, JL, 1991) |
| "Endotoxic shock is characterized by a variety of hemodynamic disturbances which result in tissue hypoperfusion." | ( Berne, RM; Headrick, JP; Young, JS, 1991) |
| "Septic shock is a life-threatening condition that results from exposure to bacterial endotoxin." | ( Adams, J; Griffith, OW; Gross, SS; Jubran, A; Kilbourn, RG; Levi, R; Lodato, RF, 1990) |
| "Treatment of septic shock is a persistent dilemma." | ( Hackshaw, KV; Parker, GA; Roberts, JW, 1990) |
| "Septic shock is a common clinical problem in the intensive care setting." | ( Boyd, JL; Chernow, B; Stanford, GG, 1989) |
| "Septic shock is known to involve increased metabolism of arachidonic acid and generation of certain eicosanoids." | ( Ashton, SH; Cook, JA; Galbraith, RM; Halushka, PV; Watt, GH; Wise, WC, 1989) |
| "Toxic shock syndrome is a devastating and potentially lethal complication, which can occur in postoperative patients." | ( Hankin, FM; Louis, DS; Smith, PA, 1986) |
| "Septic shock is a distinct clinical entity with an overall mortality of 30% to 40%." | ( Berringer, R; Harwood-Nuss, AL, 1985) |
| "Septic shock is associated with increased metabolism of arachidonic acid to thromboxane A2 (TxA2) and prostacyclin (PGI2)." | ( Cook, JA; Halushka, PV; Knapp, RG; Wise, WC, 1985) |
| "Endotoxic shock is associated with widespread intravascular thrombi, liver cell necrosis, combination of the destruction of reticuloendotheliocytes with the signs of their preceding activation, foci of a smooth cytoplasmic network hyperplasia of centrolobular hepatocytes; hypovolemic shock is characterized by activation of compensatory processes." | ( Beketova, TP; Sekamova, SM, 1985) |
| "Septic shock is a common emergency, most often caused by gram-negative bacteremia." | ( Eskridge, RA, 1983) |
| "Toxic shock syndrome is rarely reported in patients who are immunosuppressed, perhaps because such patients are often treated vigorously with antibiotics at the earliest sign of infection." | ( Birmingham, CL; Chan, RM; Graham, HR, 1983) |
| "Endotoxic shock is associated with increased metabolism of arachidonic acid into thromboxanes and prostaglandins." | ( Cook, JA; Halushka, PV; Wise, WC, 1983) |
| "Endotoxic shock is associated with increased metabolism of arachidonic acid to thromboxanes (TX) and prostaglandins (PG)." | ( Cook, JA; Halushka, PV; Wise, WC, 1981) |
| "Septic shock is an emergency that is best treated by establishing priorities beforehand." | ( Ellenbogen, C, 1982) |
| "Septic shock is known to induce progressive myocardial dysfunction characterized hemodynamically by a decrease in cardiac output and a rise in ventricular filling pressures." | ( Depeursinge, F; Perret, C, 1981) |
| "Septic shock is a life-threatening condition that results from exposure to bacterial endotoxin." | ( Chang, CH; Chang, JP; Lin, PJ, 1994) |
| "Septic shock is associated with high mortality." | ( Higa, EM; McMurtry, IF; Niederberger, M; Raynolds, M; Schrier, RW; Weigert, AL, 1995) |
| "Gram-negative septic shock is associated with severe hypotension and autonomic cardiovascular dysfunction." | ( Cox, C; DeAsla, R; DeKing, D; DeLong, DJ; Goldstein, B; Kempski, MH; Lund, N; Stair, D; Tipton, RB; Woolf, PD, 1995) |
| "Hypotension during endotoxic shock is related to reduced vascular responsiveness to vasoconstrictors." | ( Dayao, EK; Hauser, GJ; Zukowska-Grojec, Z, 1995) |
| "Because septic shock is a dynamic and evolving condition, different strategies may be needed at different stages in the pathogenesis of sepsis." | ( Cohen, J; Lynn, WA, 1995) |
| "Septic shock is the major cause of treatment-related death in patients with acute myelogenous leukaemia (AML) undergoing intensive chemotherapy." | ( Kienast, J; Mesters, RM; Ostermann, H; Rothenburger, M; van de Loo, J, 1994) |
| "Later stages of septic shock are characterized by hypotension and decreased myocardial performance." | ( Chelly, FD; Cromeens, DM; Griffith, OW; Kilbourn, RG, 1994) |
| "Endotoxic shock is presented with a complex pathophysiology and is associated with high mortality." | ( Tseng, CS; Tso, HS, 1993) |
| "Septic shock is characterized by systemic vasodilation and an impaired reactivity to vasoconstrictor agents." | ( Cañas, P; Jorge, P; Landín, L; Liste, D; Lorente, JA; Renes, E, 1994) |
| "Hypotension in septic shock is a reflection of unregulated nitric oxide (NO) production and vascular smooth muscle guanylyl cyclase activation." | ( Francis, S; Keaney, JF; Loscalzo, J; Loscalzo, JF; Puyana, JC; Stamler, JS, 1994) |
| "Toxic shock syndrome is a multisystem disease which presents with a high fever, rash, gastrointestinal symptoms, and hypotension." | ( Rose, PG; Wilson, G, 1994) |
| "Early septic shock is characterized by fever, increased cardiac output, decreased systemic vascular resistance, and dilation of higher-order arterioles in peripheral tissues, such as skeletal muscle." | ( Arden, WA; Derbin, M; Greenberg, RN; Gross, DR; Oremus, R; Pofahl, W; Schwartz, RW, 1993) |
| "Newborn endotoxic shock syndrome is associated with high morbidity and mortality, yet presents with different clinical manifestations than in older patients." | ( Grantham, KD; Li, JX; Lu, CY; Oliver, JR; Philips, JB, 1993) |
| "Endotoxic shock is associated with profound metabolic alterations including hypoglycemia and hyperlactiacidemia." | ( Geller, ER; Maitra, SR; Pan, W, 1993) |
| "Severe septic shock is associated with an imbalance between oxygen demand and oxygen supply (DO2) in the presence of an impaired oxygen extraction." | ( Bakker, J; Vincent, JL, 1993) |
| "Septic shock is characterized by coagulation activation and fibrinolysis activation and inhibition." | ( de Pablo, R; García-Avello, A; García-Frade, LJ; Landín, L; Lorente, JA; Renes, E; Torrado, C, 1993) |
| "Septic shock is a major cause of hospital deaths despite modern intensive therapy." | ( Brady, AJ, 1995) |
| "Acute endotoxic shock is accompanied by an increase in the production of nitric oxide (NO) by several different hepatic cell types." | ( Howard, KM; Mustafa, SB; Olson, MS, 1996) |
| "Septic shock is a cytokine-mediated process typically caused by a severe underlying infection." | ( Haber, E; Hsieh, CM; Lee, ME; Lee, WS; Long, NC; Lowenstein, CJ; Patterson, C; Perrella, MA; Shieh, S; Shore, S; Tsai, JC, 1996) |
| "Endotoxic shock is a life-threatening consequence of severe Gram-negative infection characterized by vascular smooth muscle cell relaxation and severe hypotension." | ( Folta, SC; Foster, L; Hsieh, CM; Lee, WS; Patterson, C; Pellacani, A; Perrella, MA; Tan, L; Yet, SF, 1997) |
| "The hypotension of septic shock is due to systemic vasodilation." | ( Ashton, RC; D'Alessandro, D; Gallant, EM; Landry, DW; Levin, HR; Oliver, JA; Oz, MC; Seo, S, 1997) |
| "Septic shock is a physiological derangement of the cardiovascular system characterized by pathological vasodilation." | ( Kilbourn, RG; Szabó, C; Traber, DL, 1997) |
| "Septic shock is a major cause of death in the world." | ( Klimpel, GR; Niesel, DW; Peterson, JW; Zhang, H, 1997) |
| "The endotoxic shock syndrome is characterized by systemic inflammation, multiple organ damage, circulatory collapse and death." | ( Bayoumy, S; Cordon-Cardo, C; Edwards, CK; Fuks, Z; Gallily, R; Garzotto, M; Haimovitz-Friedman, A; Kolesnick, R; McLoughlin, M; Schuchman, EH, 1997) |
| "Septic shock is a life-threatening disorder caused by lipopolysaccharide (LPS) and other bacterial products." | ( Kurihara, H; Kurihara, Y; Morita, H; Shindo, T; Yazaki, Y, 1998) |
| "Sepsis and septic shock are common problems in the ICU and carry a very high mortality." | ( Parker, MM, 1998) |
| "Its application in septic shock is hazardous." | ( Függer, R; Götzinger, P; Jakesz, R; Losert, U; Riegler, M; Roth, E; Sautner, T; Sedivy, R; Wessely, C, 1998) |
| "Septic shock is a major cause of death among patients in intensive care units." | ( Hon, WM; Khoo, HE; Moochhala, S, 1998) |
| "Endotoxin shock is known to impair critical cellular functions and is associated with the development of multiple organ dysfunction." | ( Salzman, AL; Szabó, A; Szabó, C, 1998) |
| "Septic shock is characterised by infection causing a systemic inflammatory response, end-organ failure and acute circulatory collapse." | ( Matthews, PC; Willatts, SM, 1998) |
| "Endotoxin shock is characterized by systemic hypotension, hyporeactiveness to vasoconstrictors and acute lung edema." | ( Chao, TJ; Chen, HI; Hsu, K; Jau, J; Lieu, MW; Wang, D; Wei, J, 1999) |
| "Septic shock is a major cause of death following trauma and is a persistent problem in surgical patients throughout the world." | ( Titheradge, MA, 1999) |
| "Endotoxic shock is a systemic inflammatory process, involving a variety of proinflammatory mediators." | ( Arita, H; Hanasaki, K; Kobayashi, T; Nakazato, H; Ono, T; Yokota, Y, 1999) |
| "Septic shock is a leading cause of mortality in intensive care units." | ( Arend, WP; Armstrong, RC; Fritz, LC; Gabay, C; Grobmyer, SR; Melchior, M; Nathan, CF; Nicholson, SC; Potter, SH, 1999) |
| "Septic shock is a complex pathophysiologic state characterized by circulatory insufficiency, multiple system organ dysfunction, and frequent mortality." | ( Arteaga, G; Becker, L; Bryant, D; Giroir, BP; Horton, J; Kliewer, A; Maass, D; Thompson, M; White, DJ, 2000) |
| "Septic shock is characterized by a decrease in systemic vascular resistance." | ( Chen, A; Chen, SJ; Chou, TC; Liao, MH; Wu, CC; Yen, MH, 2000) |
| "A major feature of septic shock is the development of a vascular crisis characterized by nonresponsiveness to sympathetic vasoconstrictor agents and the subsequent irreversible fall in blood pressure." | ( Macarthur, H; Misko, TP; Riley, DP; Salvemini, D; Westfall, TC, 2000) |
| "Sepsis and septic shock are a common cause of mortality in critically ill patients." | ( Ayem, ML; Guieu, R; Leone, M; Martin, C; Viviand, X, 2000) |
| "Septic shock is characterized by decreased responsiveness to catecholamines." | ( Annane, D; Bellissant, E, 2000) |
| "Five children with septic shock are presented who had persisting base deficit after large volume resuscitation with 0." | ( Durward, A; Mayer, A; Murdoch, IA; Skellett, S; Tibby, SM, 2000) |
| "Septic shock is one of the leading causes of death in intensive care units world-wide." | ( Annane, D, 2001) |
| "Septic shock is associated with vasopressin deficiency and a hypersensitivity to its exogenous administration." | ( Chittock, DR; Patel, BM; Russell, JA; Walley, KR, 2002) |
| "Septic shock is characterized by arteriolar vasodilation and hypotension." | ( Antunes-Rodrigues, J; Carnio, EC; De Castro, M; Giusti-Paiva, A, 2002) |
| "Both causes of septic shock are associated with an extremely high severity of illness (Acute Physiology and Chronic Health Evaluation II: candidemic septic shock, 32 +/- 10; bacteremic septic shock, 30 +/- 8; p =." | ( Hadley, S; Lee, WW; Nasraway, SA; Ruthazer, R, 2002) |
| "Candidemia with septic shock is infrequent in nonimmunocompromised patients but has a very high mortality rate, a high likelihood of associated multiple organ failure, and possibly a delayed recovery from multiple organ failure." | ( Hadley, S; Lee, WW; Nasraway, SA; Ruthazer, R, 2002) |
| "Septic shock is a serious problem in critically ill and surgical patients throughout the world." | ( Cadenas, AM; Cadenas, S, 2002) |
| "Sepsis and septic shock are very complex and dynamic clinical syndromes." | ( Knöbl, P, 2002) |
| "Severe sepsis and septic shock are relatively common problems in intensive care." | ( Parviainen, I; Ruokonen, E; Uusaro, A, 2002) |
| "Septic shock is still the major cause of death in surgical intensive care unit." | ( Cherng, CH; Chiang, CY; Ho, ST; Wang, HJ; Wong, CS; Wu, CT; Yeh, CC, 2003) |
| "Severe sepsis and septic shock are common causes of morbidity and mortality in critically ill patients." | ( Balk, RA; Gurka, DP; Patel, GP, 2003) |
| "Although septic shock is a highly complex pathophysiological state, the course of septic shock has different phases with different characteristics which need different (special) treatment strategy." | ( Guc, O; Iskit, AB, 2003) |
| "Endotoxic shock is a potentially lethal failure of multiple organs that can be initiated by the inflammatory agent lipopolysaccharide (LPS), present in the outer membrane of gram-negative bacteria." | ( Bari, M; Battista, N; Finazzi-Agrò, A; Maccarrone, M, 2002) |
| "LPS-induced septic shock is characterized by hypotension and vascular hyporeactivity to contracting agents." | ( Autore, G; Cuzzocrea, S; d'Emmanuele di Villa Bianca, R; Di Paola, R; Marzocco, S; Pinto, A; Sorrentino, R, 2004) |
| "Severe sepsis and septic shock are among the most common causes of death in noncoronary intensive care units." | ( Balk, RA, 2004) |
| "Septic shock is more severe when of early onset, as reflected by more severe organ dysfunction, greater lactic acidosis, and higher vasopressor requirements, yet the outcome is better, as reflected by a shorter duration of the shock episode, shorter ICU stay, and slightly lower mortality rates." | ( De Backer, D; Melot, C; Orellana-Jimenez, CE; Roman-Marchant, O; Vincent, JL, 2004) |
| "Septic shock is believed to be a consequence of excessive stimulation of the immune system by bacterial toxins that results in systemic overproduction of proinflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha), IL-1, and IL-6." | ( Greeneltch, KM; Haudenschild, CC; Keegan, AD; Shi, Y, 2004) |
| "Sepsis and septic shock are increasing in incidence and mortality." | ( Carrillo-Jimenez, R; Castillo, JR; Hennekens, CH; Zagler, A, 2004) |
| "Septic shock is characterized by hypotension and decreased systemic vascular resistance and impaired vascular reactivity." | ( Arendshorst, WJ; Boffa, JJ, 2005) |
| "Toxic shock syndrome is a rare but potentially fatal toxin-mediated febrile illness." | ( Asai, Y; Imaizumi, H; Kohro, S; Masuda, Y; Namiki, A; Yamakage, M, 2004) |
| "Septic shock is the reason of human body organs dysfunctions including the hormonal system." | ( Borkowski, J; Czaban, SL; Jedynak, M; Siemiatkowski, A; Wołczyński, S, 2005) |
| "Since severe toxic shock syndrome is a common complication, only immediate and aggressive surgical intervention, adequate antimicrobial therapy and supportive intensive care can be life-saving." | ( Barckow, D; Frei, U; Hasper, D; Melcher, I; Oppert, M; Schaser, KD; Schrage, D, 2005) |
| "Melioidosis with septic shock is less common than localized melioidosis in pediatric patients, but is associated with very high mortality." | ( How, HS; Ng, KH; Shah, A; Tee, HP; Yeo, HB, 2005) |
| "Septic shock is a condition that affects many organs, but little is known about the effects on the central nervous system." | ( Eriksson, MB; Hansson, LO; Larsson, A; Lipcsey, M; Sjölin, J, 2005) |
| "Septic shock is caused by Gram-negative bacterial infection." | ( Ding, JL; Ho, B; Li, P; Sun, M; Wohland, T, 2006) |
| ""Septic shock" is defined by hypotension refractory to fluid resuscitation, associated with organ dysfunctions or hypoperfusion." | ( Lebuffe, G; Vallet, B; Wiel, E, 2006) |
| "Septic shock is an important cause of death in pediatric intensive care units." | ( Kabra, SK; Lodha, R; Sarthi, M; Vivekanandhan, S, 2006) |
| "Severe sepsis and septic shock are as common and lethal as other acute life-threatening conditions that emergency physicians routinely confront such as acute myocardial infarction, stroke, and trauma." | ( Abraham, E; Abrahamian, FM; Huang, DT; Moran, GJ; Nguyen, HB; Osborn, T; Rivers, EP; Stevens, D; Talan, DA; Trzeciak, S, 2006) |
| "Septic shock is a major cause of death following trauma and a persistent problem in surgical patients." | ( Antunes-Rodrigues, J; Carnio, EC; Giusti-Paiva, A; Moreto, V, 2006) |
| "Septic shock is a systemic response to severe bacterial infections, generally caused by Gram-negative bacterial endotoxins, with multiple manifestations such as hypotension, tissue injury, disseminated intravascular coagulation, and multi-organ failure." | ( Abad, C; Arranz, A; García-Gómez, M; Gomariz, RP; Juarranz, Y; Leceta, J; Martínez, C; Rosignoli, F, 2006) |
| "Septic shock is the leading cause of death in noncoronary intensive care units and the 10th leading cause of death overall." | ( Brouckaert, P; Bultinck, J; Cauwels, A; Sips, P; Vakaet, L, 2006) |
| "The septic shock is characterized by decrease in median arterial pressure; many researchers have been related a deficiency in vasopressin release during the septic shock." | ( Antunes-Rodrigues, J; Carnio, EC; Moreto, V; Stabile, AM, 2006) |
| "Septic shock is characterised by vasodilation, myocardial depression and impaired microcirculatory blood flow, resulting in redistribution of regional blood flow." | ( Pickkers, P; Sleigh, JW; Van der Hoeven, JG; van Haren, FM, 2007) |
| "Hypodynamic septic shock is associated with a poor prognosis." | ( Booke, M; Ertmer, C; Hucklenbruch, C; Lange, M; Morelli, A; Rehberg, S; Van Aken, H; Westphal, M, 2007) |
| "Sepsis and septic shock are very common conditions among critically ill patients that lead to multiple organ dysfunction syndrome (MODS) and death." | ( Benseñor, FE; Cicarelli, DD; Vieira, JE, 2007) |
| "Septic shock is a common severe syndrome leading to endothelium damage and multiple organ failure, with increased data suggesting the principle role of oxidative stress." | ( Forceville, X, 2007) |
| "Patients with septic shock are haemodynamically unstable and suffer from vasodilation." | ( Jalowy, A; Kienbaum, P; Lehmann, N; Peters, J; Prante, C; Sander, A, 2008) |
| "Septic shock is still the leading cause of death in patients with vasculitis." | ( Tervaert, JW, 2007) |
| "Endotoxic shock is a systemic inflammatory response that is associated with an increase in nitric oxide production and a decrease in the formation of 20-hydroxyeicosatetraenoic acid (20-HETE), which may contribute to the fall in blood pressure and vascular reactivity." | ( Anjaiah, S; Buharalioglu, CK; Falck, J; Firat, SS; Korkmaz, B; Malik, KU; Roman, RJ; Tunctan, B, 2008) |
| "Septic shock is a complex syndrome that claims over 200,000 lives per year in the United States." | ( Ichinose, F, 2008) |
| "Septic shock is an adverse clinical condition resulting in multiple organ failure from global tissue hypoxia." | ( Goto, K; Hidaka, S; Kusaka, J; Noguchi, T; Oyama, Y; Shingu, C; Yamamoto, S, 2008) |
| "Vasodilatory septic shock is characterized by profound vasodilation of the peripheral circulation, relative refractoriness to catecholamines and a relative deficiency of the posterior pituitary hormone, vasopressin." | ( Holmes, CL; Walley, KR, 2008) |
| "Sepsis and septic shock are major causes of morbidity and mortality in critically ill patients." | ( Assreuy, J; Fernandes, D, 2008) |
| "Bacteremia and/or toxic shock syndrome is a rare complication of streptococcal pharyngitis in adults." | ( Bencic, IJ; Degoricija, V; Kruslin, B; Vucicevic, Z, 2008) |
| "Patients with septic shock are under considerable oxidative stress, and 2-AG plays an important role in the cardiovascular status of these patients." | ( Iwai, K; Kase, Y; Obata, T; Okamoto, Y; Saito, K; Takinami, M; Tanifuji, Y; Yokoyama, K, 2008) |
| "The incidence of septic shock is increasing and mortality ranges from 30% to 70%." | ( Russel, JA, 2008) |
| "Menstrual toxic shock syndrome is a rare but potentially life-threatening illness manifest through the actions of Staphylococcus aureus toxic shock syndrome toxin 1 (TSST-1)." | ( Frolova, O; Hoang, T; Kidder, J; McNamara, PJ; Milligan-Myhre, K; Proctor, RA; Schroeder, S; Syverson, RE, 2009) |
| "Endotoxin shock is a severe systemic inflammatory response that is caused by the augmented production and release of septic mediators." | ( Hiramatsu, K; Kuwahara-Arai, K; Murakami, T; Nagaoka, I; Obata, T; Tamura, H, 2009) |
| "Severe sepsis and septic shock are among the most important causes of morbidity and mortality in patients admitted to the intensive care unit." | ( Hollenberg, SM; Zanotti-Cavazzoni, SL, 2009) |
| "Septic shock is associated with vasopressin deficiency and hypersensitivity to its exogenous administration." | ( Hoshino, J; Katori, H; Masuoka, K; Sawa, N; Suwabe, T; Takaichi, K; Takemoto, F; Taniguchi, S; Ubara, Y; Uchida, N; Wake, A, 2009) |
| "Endotoxic shock is also associated with an increase in vasodilator prostanoids as well as a decrease in endothelial NO synthase (eNOS) and cytochrome P450 4A protein expression, and production of a vasoconstrictor arachidonic acid product, 20-hydroxyeicosatetraenoic acid (20-HETE)." | ( Buharalioglu, CK; Cuez, T; Falck, J; Korkmaz, B; Malik, KU; Sahan-Firat, S; Tunctan, B, 2010) |
| "Severe sepsis and septic shock are defined according to the criteria of the consensus conference of the ACCP/SCCM excluding the leukocyte count since all the patients were neutropenic." | ( Abid, HB; Achour, M; Aissaoui, L; Amor, RB; BelHadjAli, Z; Bouterâa, W; Jeddi, R; Kacem, K; Lakhal, RB; Meddeb, B; Turki, A, 2010) |
| "Toxic shock syndrome is an uncommon condition in patients with neutropenia." | ( Aziz, A; Gosbell, IB; Sanghavi, R; Varghese, B, 2010) |
| "Septic shock is associated with life-threatening vasodilation and hypotension." | ( Brouckaert, P; Cauwels, A; Janssen, B; Rogge, E, 2010) |
| "Septic shock is characterized by vasodilation and hypotension despite increased vasoconstrictors." | ( Giusti-Paiva, A; Santiago, MB, 2010) |
| "Sepsis and septic shock are the dominant causes of acute kidney injury, accounting for nearly 50 % of episodes of acute renal failure." | ( Chvojka, J; Karvunidis, T; Kroužecký, A; Matějovič, M; Novák, I; Raděj, J; Sýkora, R, 2010) |
| "Neonatal septic shock is a devastating condition associated with high morbidity and mortality." | ( Wong, HR; Wynn, JL, 2010) |
| "Septic shock is a major cause of morbidity and mortality in the intensive care unit, and effective therapies are limited." | ( Flynn, JD; Hatton, KW; McMahon Horner, D; Paciullo, CA, 2010) |
| "Septic shock is a major health care problem that affects a heterogeneous population of patients." | ( Bohé, J; Guignant, C; Lepape, A; Malcus, C; Monneret, G; Poitevin, F; Venet, F; Voirin, N, 2010) |
| "Death from septic shock is caused by refractory hypotension and multiple organ failure (MOF)." | ( Brouckaert, P; Cauwels, A, 2011) |
| "Severe sepsis and septic shock are common complications in the intensive care unit and associated with high mortality." | ( Drexel, H; Fraunberger, P; Walli, AK, 2010) |
| "Septic shock is the progression of those physiologic changes to the extent that delivery of oxygen and metabolic substrate to tissues is compromised." | ( Standage, SW; Wong, HR, 2011) |
| "Streptococcal toxic shock syndrome is a potentially lethal condition with an increasing incidence over the last 30 years." | ( Kohannim, O; Rubin, Z; Taylor, M, 2011) |
| "Streptococcal toxic shock syndrome is a serious health problem in developed and developing countries." | ( Müller, A; Schulze, MH; Stich, A; Tappe, D; van der Linden, M; Ziegler, U, 2011) |
| "Septic shock is the leading causes of death in intensive care units." | ( Inal, MT; Memiş, D; Sut, N, 2012) |
| "Septic shock is characterized by altered tissue perfusion associated with persistent arterial hypotension." | ( Creteur, J; De Backer, D; Donadello, K; Favory, R; Salgado, DR; Taccone, FS; Thooft, A; Vincent, JL, 2011) |
| "The hemodynamics of septic shock is characterized by a primary reduction of vascular tone, which defines vasoplegia." | ( Jeanneret, S; Liaudet, L; Sanchez, B, 2011) |
| "The presence of septic shock is a strong predictor of mortality." | ( Chakrapani, M; Damodar, S; Lipika, S; Vidyalakshmi, K; Vishal, S, 2012) |
| "Septic shock is a serious condition with a consequent drop in blood pressure and inadequate tissue perfusion." | ( Elias, LL; Giusti-Paiva, A; Rodrigues, JA; Santiago, MB; Vieira, AA, 2013) |
| "Sepsis and septic shock are common cause of hospitalisation in intensive care unit." | ( Duricová, J; Grundmann, M; Kacířová, I; Martínek, A; Petejová, N; Plášek, J; Valkovský, I; Zahálková, J, 2012) |
| "Septic shock is a systemic inflammatory response syndrome, and it is the leading cause of death in intensive care units." | ( Beduschi, MG; Buss, ZS; Dalmarco, EM; Guimarães, CL, 2013) |
| "As sepsis and septic shock are dominant causes of acute kidney injury (AKI), we investigated whether PCT is an early predictor of AKI in patients with symptoms of infection." | ( Dai, Z; Gao, B; He, Y; Huang, X; Li, G; Luo, T; Miao, Q; Nie, X; Song, H; Wang, L; Wu, B, 2013) |
| "Septic shock is a serious condition leading to high mortality and morbidity." | ( Noppakaorattanamanee, K; Permpikul, C; Poompichet, A; Ratanarat, R; Tongyoo, S, 2013) |
| "Septic shock is the leading cause of death in intensive care units worldwide, resulting from a progressive systemic inflammatory reaction causing cardiovascular and organ failure." | ( Brouckaert, P; Bultinck, J; Cauwels, A; Descamps, B; Rogge, E; Sips, M; Van Nieuwenhuysen, T; Vandendriessche, B; Vanhove, C, 2013) |
| "Sepsis and septic shock are associated with high mortality rates and the majority of sepsis patients die due to complications of multiple organ failure (MOF)." | ( Brouckaert, P; Cauwels, A; Goossens, V; Rogge, E; Stasch, JP; Vandenabeele, P; Vandendriessche, B, 2013) |
| "Septic shock is still related to unacceptably high morbidity and mortality." | ( Huang, Y; Qiu, H; Qiu, X; Xu, J; Yang, Y, 2014) |
| "Severe sepsis and septic shock are associated with high mortality." | ( Permpikul, C; Sringam, P; Tongyoo, S, 2014) |
| "Mortality from septic shock is highly heritable." | ( Boyd, JH; Nakada, TA; Russell, JA; Thair, SA; Walley, KR, 2015) |
| "Septic shock is associated with generally not only higher levels but also greater variance of maximal cortisol secretion rate when compared with control and sepsis groups." | ( Dorin, RI; Qualls, CR; Schrader, RM; Torpy, DJ; Urban, FK, 2015) |
| "Severe sepsis or septic shock is one of the rising causes for mortality worldwide representing nearly 10% of intensive care unit admissions." | ( Balaji, KN; Biswas, A; Guru Row, TN; Prasad, KD; Sekar, K; Trinath, J, 2014) |
| "Septic shock is a major healthcare problem effecting people worldwide with high mortality rate." | ( Apibunyopas, Y, 2014) |
| "Severe sepsis and septic shock are among the leading causes of mortality in the intensive care unit." | ( Bearman, GM; Gupta, RG; Hartigan, SM; Kashiouris, MG; Sessler, CN, 2015) |
| "Sepsis and septic shock are commonly present in the ICU and accompanied by significant morbidity, mortality, and cost." | ( Bornstein, S; Dröse, S; Heerdegen, L; Jennewein, C; Kanczkowski, W; Kantharajah, A; Scheller, B; Tran, N; Zacharowski, K, 2016) |
| "Septic shock is characterised by refractory hypotension and is typically managed by fluid resuscitation and administration of catecholamine vasopressors such as norepinephrine." | ( Carr, AC; Fowler, AA; Natarajan, R; Shaw, GM, 2015) |
| "Patients with septic shock are heterogeneous, making it particularly difficult to provide therapeutic recommendations that are safe and effective for all." | ( Vincent, JL, 2016) |
| "Septic shock is conceptualised as cardiovascular dysfunction, tissue perfusion and cellular abnormalities caused by infection." | ( Annane, D; Bellomo, R; Bertolini, G; Brunkhorst, FM; Deutschman, CS; Shankar-Hari, M; Singer, M, 2015) |
| "Sepsis and septic shock are the common complications in ICUs." | ( Chen, X; Lan, D; Li, T; Liu, L; Wu, H; Wu, Y; Yang, G; Zang, J; Zhu, Y, 2016) |
| "Septic shock is a major cause of death worldwide and a considerable healthcare burden in the twenty-first century." | ( Angus, DC; Kox, M; Pickkers, P; Stolk, RF; van der Hoeven, JG; van der Poll, T, 2016) |
| "Septic shock is a major healthcare problem." | ( El-Nawawy, A; Khater, D; Omar, H; Wali, Y, 2017) |
| "Refractory septic shock is defined as persistently low mean arterial blood pressure despite volume resuscitation and titrated vasopressors/inotropes in patients with a proven or suspected infection and concomitant organ dysfunction." | ( Agosta, S; Annoni, F; Antonucci, E; Gleeson, PJ; Orlando, S; Scolletta, S; Taccone, FS; Velissaris, D, 2017) |
| "Septic shock is a leading cause of mortality in intensive care units throughout the world." | ( DeGrado, JR; Schurr, JW; Szumita, PM, 2017) |
| "Septic shock is associated with high mortality." | ( Åstrand, P; Barle, H; Eksborg, S; Frostell, C; Hallengren, M, 2017) |
| "Septic shock is a life-threatening condition that occurs when the blood pressure drops to a low level after an infection." | ( Arita, Y; Hasegawa, S; Segawa, T; Yamamoto, S, 2017) |
| "Septic shock is characterized by dysregulation of the host response to infection, with circulatory, cellular, and metabolic abnormalities." | ( Ali Benali, M; Amathieu, R; Annane, D; Asehnoune, K; Baudin, F; Bellissant, E; Bohé, J; Boulain, T; Brun-Buisson, C; Capellier, G; Cariou, A; Charpentier, C; Chimot, L; Colin, G; Combes, A; Constantin, JM; Cook, F; Dargent, A; Dhonneur, G; Forceville, X; François, B; Hissem, T; Leroy, O; Loriferne, JF; Martin, C; Maxime, V; Megarbane, B; Mercier, E; Misset, B; Petitpas, F; Quenot, JP; Renault, A; Schwebel, C; Siami, S; Slama, M; Souweine, B; Timsit, JF, 2018) |
| "A key player in septic shock is Tumor Necrosis Factor-alpha (TNF-α)." | ( Elvers, M; Jurk, K; Kaup, SC; Klier, M; Krüger, I; Lang, PA; Reusswig, F; Spelleken, M; Urbahn, MA, 2018) |
| "Septic shock is a life-threatening clinical situation associated with acute myocardial and vascular dysfunction, whose pathophysiology is still poorly understood." | ( Baganha, F; Carneiro, F; Castro-Chaves, P; Cerqueira, RJ; Gonçalves, F; Heymans, S; Laundos, TL; Leite-Moreira, AF; Mendonça, L; Nascimento, DS; Paiva, JA; Pinto-do-Ó, P; Quina-Rodrigues, C; Reguenga, C; Ribeiro, S; Roncon-Albuquerque, R; Schroen, B; Soares-Dos-Reis, R; Vasques-Nóvoa, F; Verhesen, W, 2018) |
| "Endotoxin shock is a life-threatening response caused by a disordered immune response to an infection." | ( Dai, J; Dong, G; Fang, R; Li, C; Li, Z; Ma, Q; Ming, J; Ning, Z; Shi, H; Si, C; Xiong, H; Yan, F; Zhang, H; Zhang, J, 2018) |
| "Septic shock is a life-threatening disorder associated with high mortality rates requiring rapid identification and intervention." | ( Bauer, SR; Lat, I; Sacha, GL, 2019) |
| "Urosepsis and septic shock are a critical situation leading to a mortality rate up to 30% in patients with obstructive diseases of the urinary tract." | ( Gong, S; Hu, X; Jiang, Y; Li, J; Shang, X; Yu, R; Zhang, X; Zhang, Y, 2019) |
| "Septic shock is a life threatening condition and a medical emergency." | ( Jadhav, AP; Sadaka, FG, 2019) |
| "Septic shock is a serious stage of sepsis with a hospital mortality rate of more than 40%." | ( Chen, Q; Liu, L; Zheng, R, 2019) |
| "Septic shock is associated with poor outcomes." | ( Bailey, M; Bellomo, R; Deane, AM; Eastwood, GM; Frei, D; French, C; Fujii, T; Luethi, N; Orford, N; Shehabi, Y; Udy, AA; Young, PJ, 2019) |
| "Sepsis and septic shock are significant health issues in the United States." | ( Grace, Y; Guirguis, E; Maarsingh, H; Tkachuk, E; Tran, TC, 2020) |
| "Septic shock is a life-threatening condition with underlying circulatory and cellular/metabolic abnormalities." | ( Choi, SH; Chung, SP; Hwang, SY; Jo, IJ; Jo, YH; Kim, D; Kim, S; Kim, T; Kim, WY; Kim, YJ; Kong, T; Lee, HJ; Park, JE; Ryoo, SM; Shin, J; Shin, TG; Suh, GJ; You, KM, 2019) |
| "Septic shock is characterized by severe metabolic and hemodynamic alterations." | ( Brandenburger, T; Dimski, T; Kindgen-Milles, D; Slowinski, T, 2020) |
| "Sepsis and septic shock are medical emergencies resulting in significant morbidity and mortality." | ( Gillion, AR; Mitchell, AB; Muthiah, MP; Ryan, TE; Wells, LD, 2020) |
| "Sepsis and septic shock are major causes of morbidity and mortality worldwide, associated with a high economic and social burden on healthcare systems and communities, yet with few definite treatment modalities." | ( Al Kurdi, MH; Aletreby, WT; Alharthy, AM; Alodat, MA; Alzayer, W; Farrag, HA; Hamido, HM; Huwait, BM; Karakitsos, D; Madi, AF; Mahmood, NN; Mumtaz, SA; Ramadan, OE; Soliman, IR, 2019) |
| "Septic shock is a systemic inflammation associated with cell metabolism disorders and cardiovascular dysfunction." | ( Aillerie, V; Bigot, E; Cadiet, J; Chatham, JC; Denis, M; Erraud, A; Ferron, M; Gauthier, C; Lauzier, B; Mevel, M; Persello, A; Prat, V; Rozec, B, 2019) |
| "Septic shock is a common and highly morbid condition." | ( Andersen, LW; Donnino, MW; Grossestreuer, AV; Huang, DT; Moskowitz, A; Yankama, T, 2019) |
| "Septic shock is associated with massive release of endogenous catecholamines." | ( Beilstein, C; Boerma, C; Calcinaro, S; Chiche, JD; D'Egidio, A; Damiani, E; Domizi, R; Donati, A; Harris, S; Koetsier, PM; Madden, MP; McAuley, DF; Morelli, A; Pelaia, P; Royer, P; Shankar-Hari, M; Singer, M; Wickboldt, N; Zolfaghari, P, 2020) |
| "Septic shock is the main cause of morbidity and mortality in patients and second leading cause of mortality among subjects in noncoronary intensive care units." | ( Khodashahi, R; Sarjamee, S, 2020) |
| "Sepsis and septic shock are characterized by a release of cytokines into the circulation." | ( Brandenburger, T; Dimski, T; Kindgen-Milles, D; MacKenzie, C, 2020) |
| "Septic shock is associated with a strong inflammatory response that induces vasodilation and vascular hyporeactivity." | ( Bédos, JP; Bruneel, F; Henry-Lagarrigue, M; Legriel, S; Soppelsa, F; Spreux-Varoquaux, O; Troché, G; Yehia, A, 2020) |
| "Septic shock is associated with decreased vasopressor responsiveness." | ( Bailey, M; Bellomo, R; Cioccari, L; Eastwood, GM; Howe, B; Jakob, SM; Luethi, N; Merz, TM; Messmer, AS; Peck, L; Proimos, HK; Shehabi, Y; Takala, J; Young, H, 2020) |
| "Septic shock is a life-threatening manifestation of infection with a mortality of 20-50% [1]." | ( Brown, SM; Harley, JB; Sorensen, J; Tang, Y, 2021) |
| "Septic shock is a leading cause of death and morbidity worldwide." | ( Day, J; Donovan, K; McKechnie, SR; Shah, A, 2021) |
| "Septic shock is characterized by breakdown of the endothelial glycocalyx and endothelial damage, contributing to fluid extravasation, organ failure and death." | ( Bellani, G; Caironi, P; Coppolecchia, S; Ferlicca, D; Fracasso, C; Gattinoni, L; Gobbi, M; Grasselli, G; Latini, R; Marino, A; Masson, S; Meessen, JMTA; Novelli, D; Pesenti, A; Piotti, A; Salati, G; Savioli, M, 2021) |
| "Toxic shock syndrome is a potentially deadly toxin-mediated disease in which quick diagnosis is imperative for treatment and prognosis." | ( Barfod, TS; Gani, K; Haase, N; Nielsen, SD; Ribberholt, I, 2021) |
| "Sepsis and septic shock are severe medical conditions that can damage multiple organs with a higher risk of mortality." | ( Lee, YR; Varughese, JT; Vo, K, 2022) |
| "Septic shock is characterized by dysregulated vascular permeability." | ( Higashijima, U; Izumikawa, K; Kakiuchi, S; Mori, M; Morimoto, K; Sekino, M; Takaki, M; Tanaka, T; Tasaki, O; Tashiro, M; Yamashita, Y, 2021) |
| "Septic shock is characterized by an uncontrolled inflammatory response and microcirculatory dysfunction." | ( Chen, L; Gao, Y; Hong, Y; Hu, C; Huang, Z; Liu, D; Ren, B; Tian, X; Wang, X; Yin, R; Yu, Y; Zhang, C; Zhang, Z; Zhou, J; Zhu, C, 2021) |
| "Septic shock is associated with increased mortality because of an inadequacy to maintain mean arterial blood pressure (MAP) despite volume resuscitation and the use of vasopressors." | ( Balakumar, P; Jagadeesh, G; Senatore, F, 2021) |
| "Endotoxin shock is associated with severe impairments in cardiovascular and respiratory functions." | ( Buturak, A; Cansev, M; Ceron, JJ; Kocaturk, M; Ozarda, Y; Ulus, IH; Yilmaz, Z, 2021) |
| "Septic shock is a lethal disease responsible for a large proportion of deaths in the Intensive Care Unit (ICU), even with therapy centered on fluid resuscitation, use of vasopressors and empirical antibiotic therapy applied within the first hour of diagnosis." | ( Auxiliadora-Martins, M; Basile-Filho, A; Becari, C; Evora, PRB; Luis-Silva, F; Martins-Filho, OA; Menegueti, MG; Peres, LM; Petroski-Moraes, BC; Sato, L; Sepeda, CDR, 2022) |
| "Septic shock is often characterized by tachycardia and a hyperdynamic hemodynamic profile." | ( Balaji, L; Berg, K; Chase, M; Cocchi, MN; Dargin, J; Donnino, MW; Grossestreuer, A; Liu, X; Moskowitz, A; Patel, PV, 2022) |
| "Septic shock is an acute pathophysiological condition characterized by vasodilation, hypotension, decreased circulating blood volume, tissue hypoxia, organ failure, and high lethality." | ( Machavariani, K; Pachkoria, E; Ratiani, L; Rurua, M; Sanikidze, T; Shoshiashvili, V, 2022) |
| "Septic shock is characterized by hypotension requiring vasopressors after adequate fluid resuscitation with elevated lactate." | ( Dellinger, RP; Patel, S; Puri, N, 2022) |
| "Septic shock is a serious clinical syndrome leading to high mortality." | ( Chen, H; Du, Y; Huang, S; Jia, Z; Long, G; Pei, Z; Wang, Q; Wei, K; Wu, M; Xia, W; Zhang, Y, 2023) |
| "Sepsis and septic shock are severe and difficult-to-treat conditions with high lethality." | ( Guedes, GV; Minicucci, MF; Tanni, SE, 2022) |
| "Sepsis and septic shock are the most common causes of death in non-cardiac surgical intensive care units (ICU)." | ( Bucher, M; Burgdorff, AM; Christel, A; Dinse, CM; Flöther, L, 2022) |
| "Sepsis and septic shock are the most common causes of death in non-cardiac surgical intensive care units (ICU)." | ( Bucher, M; Burgdorff, AM; Christel, A; Dinse, CM; Flöther, L, 2022) |
| "Sepsis and septic shock are the most common causes of death in non-cardiac surgical intensive care units (ICU)." | ( Bucher, M; Burgdorff, AM; Christel, A; Dinse, CM; Flöther, L, 2022) |
| "Sepsis and septic shock are the main causes of mortality and complications in intensive care units all over the world." | ( Abbasalizad Farhangi, M; Askari, G; Karimi, A; Karimi, M; Vajdi, M, 2023) |
| "Septic shock is a leading cause of death in intensive care units (ICUs), with short-term mortality rates of 35-40%." | ( Gu, WJ; He, D; Hu, H; Li, C; Lu, X; Lyu, J; Qiu, M; Yin, H; Zhang, L, 2023) |
| "Septic shock is even rarer, with high mortality despite therapy." | ( Ausman, C; Edmondson, J; Ewers, EC; Maves, RC; McCool, I; Perry, A; Walsh, JC; Wisniewski, P, 2023) |
| "Sepsis and septic shock are disorders of tissue perfusion and microcirculation associated with increased mortality." | ( Turan, YB, 2023) |
| "Septic shock is one of the leading causes of mortality in intensive care units." | ( Fu, Q; Fu, S; Liang, TB; Xu, Z; Yu, W; Zhang, S, 2023) |
| "Septic shock is a global public health burden." | ( Chen, Y; Gao, S; Guo, Y; He, H; Hu, Y; Liu, D; Ma, X; Shan, G; Su, L; Wang, L; Zhou, X, 2023) |
| "Septic shock is the development of sepsis to refractory circulatory collapse and metabolic derangements, characterized by persistent hypotension and increased lactate levels." | ( Chen, MZ; Deng, X; Dong, X; Guo, SB; Li, AJ; Lin, JH; Lin, ZF; Lin, ZH; Liu, JX; Mei, X; Shi, B; Tian, YP; Yuan, DS; Yuan, SY; Zha, JJ; Zhang, F; Zhang, L; Zhou, P, 2023) |
| Excerpt | Reference |
|---|
| "A study of 113 patients with septic shock admitted to an intensive therapy unit (I." | ( Ledingham, IM; McArdle, CS, 1978) |
| "The course and therapy of endotoxin shock were studied in 34 monkeys Macaca mulatta." | ( Hájek, M; Helfert, I; Misák, J; Trcka, V; Vanĕcek, M, 1978) |
| "2 fatal cases of endotoxin shock after antibiotic therapy due to massive Escherichia coli infection after surgery are described to emphasize this rare possibility of complication." | ( Aufschnaiter, M; Margreiter, R; Salzer, GM; Semenitz, E, 1978) |
| "An effective therapy for endotoxin shock, particularly in combination with significant liver damage, has not been available to date." | ( Hinshaw, LB; McCallum, RE; Pegues, AS; Sofer, SS, 1979) |
| "In Part I, 172 consecutive patients in septic shock admitted over an 8-year period were treated with either steroid or saline: 43 received dexamethasone (DMP), 43 received methylprednisolone (MPS), and 86 received saline." | ( Schumer, W, 1976) |
| "In part 1, 172 consecutive patients in septic shock admitted over an 8-year period were treated with either steroid or saline: 43 received (DMP) dexamethasone; 43 received (MPS) methylprednisolone; and 86 received saline." | ( Schumer, W, 1976) |
| "Increased resistance against endotoxin shock and Ehrlich's ascites tumor challenge was also observed in zinc treated animals." | ( Murthy, RC; Raisuddin, S; Ray, PK; Saxena, AK; Singh, KP; Zaidi, SI, 1992) |
| "The diagnostic similarities of toxic shock syndrome and the toxic shock-like syndrome caused by group A Streptococcus could have led to inappropriate treatment." | ( Erstad, BL; Talkington, DF; Witte, CL, 1992) |
| "The use of NA in septic shock with low SVR showed an improvement in hemodynamic condition and a higher survival rate in the treated patients." | ( Bacciu, PP; Gherli, T; Mastroni, P; Padua, G; Piredda, G; Porcu, A; Ruju, P; Sale, MA, 1992) |
| "During experimental septic shock, alinidine administration can reverse dobutamine-induced tachycardia and simultaneously improve ventricular function." | ( Moulart, D; Preiser, JC; Vincent, JL, 1992) |
| "In coenzyme Q10 treated endotoxin shock rats, superoxide production was significantly decreased, and lipid peroxide production in the liver was also inhibited." | ( Suzuki, H, 1991) |
| "In this study of controlled endotoxic shock, we investigated the protective effects of prophylactic corticosteroid treatment against activation of cellular and plasmatic systems." | ( Hoiting, BH; Jansen, NJ; van Oeveren, W; Wildevuur, CR, 1991) |
| "Patients in septic shock require rapid evaluation and prompt initiation of therapy with appropriate antibiotics and fluids." | ( Smally, AJ, 1991) |
| "Patients with septic shock were treated with either dopamine or norepinephrine to correct hypotension." | ( Ruokonen, E; Takala, J; Uusaro, A, 1991) |
| "Thirteen patients with septic shock (diagnosed by defined criteria) requiring pharmacologic support for the treatment of hypotension." | ( Bonfiglio, MF; Dasta, JF; Flancbaum, L; Gregory, JS; Reilley, TE; Townsend, MC, 1991) |
| "Treatment plans for pediatric septic shock advocate increasing oxygen consumption (VO2)." | ( Mink, RB; Pollack, MM, 1990) |
| "Treatment of septic shock is a persistent dilemma." | ( Hackshaw, KV; Parker, GA; Roberts, JW, 1990) |
| "In a porcine endotoxin shock model employing a continuous intravenous administration of Salmonella abortus equi endotoxin the cardiorespiratory and metabolic parameters were studied with main emphasis on the effect of hemofiltration (HF) as the only therapeutical measurement on the enhancement of survival time." | ( Hohlbach, G; Kooistra, A; Rau, HG; Schardey, HM; Schilberg, FW; Staubach, KH, 1989) |
| "Specific treatments in septic shock should be instituted administration of glucocorticoid, antibiotics, protease inhibitor and lipoxygenase inhibitor." | ( Asaishi, K; Ebata, T; Hasegawa, I; Hayasaka, H; Hiraike, N; Minamida, H; Yamamoto, Y, 1989) |
| "The multidimensional pathophysiology of septic shock is poorly understood and treatment modalities are controversial." | ( Dawidson, I; Ottosson, J; Persson, T, 1989) |
| "Treatment of septic shock with naloxone was evaluated in a prospective, randomised, double-blind, placebo-controlled study in which ten episodes of shock were treated with naloxone (0." | ( Carven, DE; DeMaria, A; Grindlinger, GA; Heffernan, JJ; McCabe, WR; McIntosh, TK, 1985) |
| "In dogs with Escherichia coli-induced endotoxin shock, this hyperinsulinism was in response to glucose administration." | ( Anderson, JH; Merrill, GA, 1987) |
| "These data suggest that during endotoxic shock there is an attenuation of IP3- and AA-induced intracellular Ca2+ release, which could be prevented by treatment of animals with diltiazem." | ( Maitra, SR; Sayeed, MM, 1987) |
| "coli septic shock with acute pulmonary hypertension, prostaglandin E1 and MPS treatment decrease pulmonary vascular resistance but also systemic vascular resistance." | ( Groeneveld, AB; Heidendal, GA; Kester, AD; Schneider, AJ; Teule, GJ; Thijs, LG; van Halderen, P, 1987) |
| "The severe signs of septic shock were reversed in seven of 15 patients on anti-lipid A compared to two of seven patients treated with placebo." | ( Hoffmann, K; Jaspers, L; Kastenbauer, E; Langecker, P; Mar, PJ; Marget, W; Obermeier, A; Ruckdeschel, G, 1987) |
| "During the first 6 h of endotoxin shock, sensomotoric and sympathetic blockade distal to spinal segment T4 was achieved by intermittent administration of bupivacaine into a thoracic peridural catheter." | ( Börner, U; Knorpp, K; Reinhardt, W; Richardt, G; Schmahl, FW; Schnapper, F; Weber, G, 1987) |
| "Naloxone treatment of endotoxin shock has been shown to alter many cardiovascular parameters." | ( Ferguson, JL; Law, WR, 1987) |
| "Our prior work demonstrated in a canine endotoxic shock model (LD100) that the cyclooxygenase inhibitor ibuprofen given 60 minutes after endotoxin administration could improve hemodynamics but not survival over control animals." | ( Hamburger, SA; Hastings, GH; Judy, WV; Toth, PD, 1985) |
| "In nine patients in anaerobic septic shock, five of them with hepatic injury compatible with sepsis liver failure, hematic chloramphenicol concentration was determined at 5 minutes, 1, 2, 3 and 6 hours after intravenous administration of the first of three daily dose (50 mg/k/day); in the hepatic failure group the procedure was repeated with the next dose, previous attempt of haemodynamic compensation with two hours dopamine (3-10 mcg/k/min." | ( Dana, R; Flores, C; Jmelnitzky, AC; Lauri, IH; Moday, MC; Vitale, A, 1985) |
| "Following induction of septic shock in a separate group of splenectomized animals, treatment with naloxone (3 mg/kg bolus and 2 mg/kg/hr infusion) did not alter the rise in plasma beta-EI." | ( Bowen, JC; MacPhee, AA; Payne, JG; Rees, M, 1983) |
| "PPT seen in endotoxin shocked controls was obviated by naloxone treatment; this effect was more pronounced in pretreated dogs." | ( Almqvist, P; Kuenzig, M; Schwartz, SI, 1983) |
| "Group I (n = 8): septic shock controls without naloxone; group II (n = 8): naloxone treated, given as 2 mg/kg/hr intravenous boluses, starting within 1 min of E." | ( Chiu, RC; Hinchey, EJ; Mamazza, J, 1984) |
| "The untreated endotoxin shock group showed marked increase in thromboxane B2 levels in the venous blood, while no such changes were seen in the pretreated groups." | ( Fukumoto, S; Tanaka, K, 1983) |
| "Deaths in septic shock continue to occur at a high frequency despite current treatment programs." | ( Alestig, K; Haglund, U; Hellman, A; Lundberg, D, 1983) |
| "In a canine endotoxic shock model (LD100), we studied the effects of opiate and prostaglandin inhibition 60 min after endotoxin administration." | ( Hamburger, SA; Judy, WV; Toth, PD, 1984) |
| "In conclusion, primates in septic shock are clearly protected with delayed steroid/antibiotic therapy." | ( Archer, LT; Beller-Todd, BK; Benjamin, B; Flournoy, DJ; Hinshaw, LB; Passey, R, 1981) |
| "Since rational therapy for septic shock must combat early changes, it would seem that measures that restore G6P levels might prevent the disturbed carbohydrate metabolism that characterizes late and severe sepsis." | ( Holtzman, SF; Kuttner, RE; Schumer, W, 1980) |
| "Fourteen patients with severe septic shock requiring adrenergic therapy." | ( Carlier, E; De Backer, D; Kahn, RJ; Leeman, M; Lejeune, P; Preiser, JC; Roman, A; Vincent, JL, 1995) |
| "NO appears to play a role in septic shock; however, the use of NOS inhibitors to treat septic shock requires further studies to determine an appropriate dosing regimen and to determine the effects of these agents on morbidity and mortality." | ( Dasta, JF; Wolfe, TA, 1995) |
| "In the two models of septic shock, prophylactic treatment with fusidin, 80 mg/kg given three times for 2 days prior to D-Gal/SEB or D-Gal/LPS challenge, drastically reduced the lethality compared with D-Gal/buffer-treated mice." | ( Bendtzen, K; Di Marco, R; Grasso, S; Magro, G; Meroni, PL; Morrone, S; Nicoletti, F; Santoni, A; Tempera, G; Zaccone, P, 1995) |
| "Future clinical trials in treating septic shock should therefore consider the preferential inhibition of iNOS while maintaining the integrity of endothelial NOS." | ( Higa, EM; McMurtry, IF; Niederberger, M; Raynolds, M; Schrier, RW; Weigert, AL, 1995) |
| "In patients with acute lung injury and septic shock, bacterial coinfection should be suspected and treated empirically since it contributes substantially to early mortality." | ( Gachot, B; Nissack, G; Vachon, F; Veber, B; Wolff, M, 1995) |
| "In patients with septic shock, intravenous immunoglobulin administration leads to a decrease in plasma fibrinogen, whereas plasma viscosity and red cell aggregation remain unaffected." | ( Ehringer, H; Grimm, G; Koppensteiner, R; Kramer, L; Kranz, A; Lenz, K; Madl, C; Schneeweiss, B; Wendelin, B, 1993) |
| "DTC can reverse septic shock that is refractory to conventional therapy, and these results suggest that EDRF is an important mediator of septic shock." | ( Broner, CW; Fairclough, D; Hildner, WK; Rehg, JE; Shenep, JL; Stokes, DC; Storgion, SA, 1993) |
| "These data suggest that diltiazem treatment in endotoxic shock improves hypoglycemia and attenuates hyperlacticacidemia." | ( Geller, ER; Maitra, SR; Pan, W, 1993) |
| "Since fungal septic shock with acute disseminated candidiasis evolves prior to significant increases in circulating TNF, PTX also appears ineffective in its treatment." | ( Lechner, AJ; Matuschak, GM; Potthoff, LH; Rouben, LR; Tredway, TL, 1993) |
| "In patients with septic shock treated with catecholamines, no variation of either systemic hemodynamics or renal function was noted during low-dose dopamine infusion." | ( Bordes, P; Lherm, T; Rossignol, M; Troché, G; Zazzo, JF, 1996) |
| "Recombinant toxic shock syndrome toxin-1 (rTSST-1) administered to MRL-lpr/lpr TCR V beta 8." | ( Bluethmann, H; Bonventre, PF; Cullen, CM; Edwards, CK; Heeg, H; Mountz, JD, 1995) |
| "In a mouse model of septic shock, intravenous administration of SJC13 5 min prior to LPS injection prevented significantly the lethality at doses of 3 mg/kg and 10 mg/kg." | ( Sakai, A, 1996) |
| "A convenience sample of 15 septic shock patients treated with norepinephrine and 13 patients with severe sepsis who did not receive norepinephrine." | ( Bredle, DL; Hannemann, L; Hassel, H; Meier-Hellmann, A; Reinhart, K; Specht, M, 1996) |
| "11 patients with septic shock, diagnosed according the criteria of the 1992 American College of Chest Physicians/Society of Critical Care Medicine consensus conference, who required treatment with norepinephrine." | ( Bredle, DL; Hannemann, L; Meier-Hellmann, A; Reinhart, K; Specht, M; Spies, C, 1997) |
| "Eight patients with septic shock, according to the criteria of the 1992 American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference, requiring treatment with vasopressors." | ( Bredle, DL; Hannemann, L; Meier-Hellmann, A; Reinhart, K; Specht, M; Spies, CD, 1997) |
| "In this model of endotoxin septic shock, L-NAME administration resulted in histologic and coagulation changes consistent with an increased activation of intravascular coagulation." | ( Chopin, C; Fourrier, F; Gosselin, B; Goudemand, J; Jourdain, M; Leroy, X; Mangalaboyi, J; Tournoys, A; Vallet, B, 1997) |
| "In a porcine endotoxin shock model, the mixed nonpeptide endothelin receptor antagonist bosentan was administered 2 h after onset of endotoxemia (n = 8)." | ( Alving, K; Oldner, A; Rudehill, A; Sollevi, A; Wanecek, M; Weitzberg, E, 1997) |
| "Consequently, survival from endotoxin shock of D609-treated animals was significantly improved compared with control animals (45% vs." | ( Meisner, M; Schmidt, J; Tschaikowsky, K, 1998) |
| "We conclude that in this model of endotoxic shock the administration of BB-882, either before or after endotoxin challenge, has time-related beneficial hemodynamic and cardiac effects but does not improve global oxygen extraction capabilities." | ( Smail, N; Spapen, H; Verhaeghe, V; Vincent, JL; Zhang, H, 1998) |
| "29 multiple organ failure patients with septic shock were studied during the first 48 h of continuous hemofiltration: 18 were submitted to CAVH and 11 patients were treated with CAVHD to correct ARF and fluid overload." | ( Casciani, CU; Di Giulio, S; Meloni, C; Meschini, L; Morosetti, M; Palombo, G; Taccone-Gallucci, M; Turani, F; Zupancich, E, 1998) |
| "Twenty-one patients with septic shock treated with high-dose noradrenaline were studied, 17 patients completed the study." | ( Juste, RN; Panikkar, K; Soni, N, 1998) |
| "To mimic the treatment of septic shock in humans, mean arterial pressure was maintained in two groups at >70 mm Hg with the administration of epinephrine or norepinephrine." | ( Függer, R; Götzinger, P; Jakesz, R; Losert, U; Riegler, M; Roth, E; Sautner, T; Sedivy, R; Wessely, C, 1998) |
| "Emerging adjunctive therapy for septic shock can be divided into those directed against bacterial components, those directed against host-derived inflammatory-mediators and those designed to limit tissue damage." | ( Oh, HM, 1998) |
| "In human septic shock, inhibition of NO synthesis has been shown to alter hemodynamic variables in short-term studies, but it is uncertain whether this treatment has beneficial long-term effects." | ( Kirkebøen, KA; Strand, OA, 1999) |
| "In norepinephrine-treated septic shock, low doses of neither dobutamine nor dopexamine caused significant effects on systemic hemodynamics and renal function and both dobutamine and dopexamine inconsistently improved the PCO(2) gap." | ( Bollaert, PE; Dousset, B; Larcan, A; Levy, B; Mallie, JP; Nace, L, 1999) |
| "A 45-year-old female with meningococcal septic shock, purpura fulminans and multiple organ failure who was treated in an eight-bed medical intensive care unit of a University hospital." | ( Biedermann, H; Buratti, T; Joannidis, M; Pechlaner, C; Wiedermann, CJ, 1999) |
| "In several animal models of septic shock, treatment with inhibitors of NO synthesis has been shown to improve haemodynamic variables and survival." | ( Kirkebøen, KA; Strand, OA, 1999) |
| "Initial management of septic shock entails urgent and emergent stabilization of the patient followed by broad-spectrum, empiric antibiotic therapy." | ( Dellinger, RP; Hollenberg, SM; Jindal, N, 2000) |
| "Gram-positive septic shock was induced by coadministration of LTA (3 mg/kg i." | ( Cuzzocrea, S; Foster, SJ; Olbrich, A; Thiemermann, C; Zacharowski, K, 2000) |
| "To investigate, during endotoxic shock, the effect of a treatment of norepinephrine (NE) administration on the distribution of blood flow and adenosine triphosphate (ATP) content in the intestinal wall." | ( Frascarolo, P; Joseph, JM; Liaudet, L; Markert, M; Martinet, O; Revelly, JP, 2000) |
| "In patients with septic shock, the Emax of phenylephrine is decreased, whereas its ED50 is not modified, both before and after administration of hydrocortisone." | ( Annane, D; Bellissant, E, 2000) |
| "We report a case of a septic-toxic shock due to rhabdomyolysis in a 75-year old patient, who had been treated with fenofibrate for 2 years." | ( Dabrowska, M; Duda-Król, W; Jórasz, I; Kusz-Rynkun, A; Polubiec, A, 2000) |
| "Thirty septic shock patients with acute renal failure were randomized to either CVVH (n=20) or IHD (n=10) groups for renal replacement therapy." | ( Baumgärtel, M; Geiger, H; Griesbach, D; John, S; Schmieder, RE; Weihprecht, H, 2001) |
| "During brief dopamine treatment of endotoxic shock in rats, neither dopamine nor cysteinyl-dopamine crossed the blood-brain barrier." | ( Baines, AD; Drangova, R; Magnay, JL; Tong, J, 2001) |
| "Routine resuscitation from septic shock (surgery, fluid loading, and administration of catecholamines and antibiotic drugs)." | ( Kimura, S; Matsuyama, S; Sakano, T; Shibuya, M; Tanaka, R; Yoshioka, T, 2001) |
| "A lethal endotoxic shock was induced by administration of lipopolysaccharide (LPS) into D-galactosamine (D-GalN)-sensitized mice and another one was done by administration of a high dose of LPS into normal mice." | ( Kato, Y; Koide, N; Morikawa, A; Mu, MM; Sugiyama, T; Takahashi, K; Yokochi, T; Yoshida, T, 2001) |
| "To review all cases of septic shock treated with vasopressin to determine the effects on hemodynamic and renal function and to document any adverse effects." | ( Chittock, DR; Holmes, CL; Lehman, T; Russell, JA; Walley, KR, 2001) |
| "Ibuprofen administration during endotoxin shock seems to decrease the elevated ET concentrations, and increase the blood pressure." | ( Akbulut, A; Canbaz, M; Celik, I; Vural, P, 2002) |
| "Thirteen piglets were subjected to endotoxic shock and divided into a fluid-therapy group that received 0." | ( Chin, A; Fornell, L; John, E; Radhakrishnan, J, 2002) |
| "Fifteen patients with septic shock associated with persisting hypotension despite conventional treatment including fluid loading, vasopressors, and inotropes." | ( Coltrinari, R; Conti, G; Donati, A; Loggi, S; Münch, C; Pelaia, P; Pietropaoli, P; Preiser, JC, 2002) |
| "Compared to that of septic shock group, MABP of rats in ghrelin-treated group increased by 33 % (P <0." | ( Chang, L; Du, JB; Gao, LR; Pang, YZ; Tang, CS, 2003) |
| "The model of septic shock was used to examine the expression of HSP70 in rat liver and the TNF-alpha level of blood at 2 hours after endotoxin treatment and dying time for endotoxin group rats." | ( Liu, B; Wang, Q; Xiao, H; Zhang, L, 2001) |
| "The authors describe a case of septic shock refractory to high-dose catecholamines after adequate volemic filling, rapidly corrected with the administration of desmopressin at a dose of 0." | ( Conti, G; Marchese, M; Mignani, V; Pennisi, MA; Poleggi, P, 2002) |
| "In this clinically relevant model of septic shock due to peritonitis, vasopressin administration (alone or with norepinephrine) can prolong survival." | ( De Backer, D; Dimopoulos, G; Hoang, AD; Nagy, N; Nguyen, DN; Rogiers, P; Sun, Q; Tu, Z; Vincent, JL, 2003) |
| "A patient with meningococcal septic shock was treated with two doses of the unactivated form of protein C, the first during intense activation of the coagulation system and the second during a phase of low grade or no activation." | ( Gedeborg, R; Lignell, A; Pauksen, K; Siegbahn, A; Sjölin, J; Stridsberg, M, 2003) |
| "Although septic shock is a highly complex pathophysiological state, the course of septic shock has different phases with different characteristics which need different (special) treatment strategy." | ( Guc, O; Iskit, AB, 2003) |
| "In patients with septic shock presenting adrenal insufficiency, either suspected or confirmed, the administration of hydrocortisone in shock or stress doses can be vital for a favorable clinical outcome." | ( Branco, RG; Casartelli, CH; Garcia, PC; Piva, JP, 2003) |
| "Patients with septic shock were allocated to receive 546C88 or placebo (5% dextrose) for up to 7 days (stage 1) or 14 days (stage 2) in addition to conventional therapy." | ( Anzueto, A; Arneson, C; Bakker, J; Breen, D; Brockway, M; Donaldson, J; Grossman, S; Grove, G; Grover, R; Holzapfel, L; López, A; Lorente, JA; McLuckie, A; Silverman, MS; Steingrub, J; Takala, J; Willatts, S, 2004) |
| "Since the mechanism of GBS toxic shock may be similar to Group A Streptococcus, intravenous immunoglobulin should be considered as an adjunct to clindamycin-based antibiotic therapy." | ( Crum, NF; Wallace, MR, 2003) |
| "Standard septic shock therapy includes supportive treatment such as fluid resuscitation, administration of vasopressors (adrenergic and nonadrenergic drugs), and respiratory and renal support." | ( Asfar, P; De Backer, D; Meier-Hellmann, A; Radermacher, P; Sakka, SG, 2004) |
| "The problem of sepsis and septic shock (SSH) is known to be very actual due to peak-shaped growth of the number of such patients and unsatisfactory results of treatment." | ( Bagnenko, SF; Grinev, MV; Gromov, MI; Kulibaba, DM, 2004) |
| "Yet the role of EP4 receptors in endotoxin shock in vivo and whether EP4 activation is a beneficial treatment are not clear." | ( Gotoh, Y; Matsumura, J; Mii, S; Ogawa, R; Sakamoto, A, 2004) |
| "There were three deaths due to septic shock that were possibly or probably treatment-related." | ( Boussard, B; Carmichael, J; Daniel, F; Davidson, N; Falk, S; Jacobs, C; Kuehr, T; Rapoport, BL; Ruff, P; Thaler, J, 2004) |
| "In part 1 the endotoxic shock model showed a significant reduction in TNF levels in the spironolactone-treated group compared to the non-treated group, suggesting that spironolactone acts as a TNF inhibitor." | ( Bendtzen, K; Bentzen, BH; Björnsson, M; Grauballe, MC; Holmstrup, P; Jonassen, TE; Moe, D; Stoltze, K, 2005) |
| "Since severe toxic shock syndrome is a common complication, only immediate and aggressive surgical intervention, adequate antimicrobial therapy and supportive intensive care can be life-saving." | ( Barckow, D; Frei, U; Hasper, D; Melcher, I; Oppert, M; Schaser, KD; Schrage, D, 2005) |
| "All consecutive 111 patients with septic shock treated in our ICU between 1 Jan." | ( Pettilä, V; Saukkonen, K; Tallgren, M; Varpula, M; Voipio-Pulkki, LM, 2005) |
| "In a murine endotoxic shock model, administration of a low molecular weight inhibitor diminished the rise in enzymatic activity and improved the survival rate." | ( Bockmeyer, CL; Brunkhorst, FM; Bunck, AC; Claus, RA; Deigner, HP; Kinscherf, R; Lösche, W, 2005) |
| "Twenty-two septic shock patients with at least two organ failures were retrospectively investigated for MAP and the required dose of norepinephrine before and 24 h after rhAPC administration." | ( Anguel, N; Bonmarchand, G; Lamia, B; Monnet, X; Richard, C; Teboul, JL, 2005) |
| "Using an endotoxic shock model, 60 male Wistar rats were randomly divided into normal controls (n = 8), endotoxic shock group (n = 32) and PD98059 treatment group (n = 20)." | ( Sheng, ZY; Xu, CL; Yao, FH; Yao, YM; Yu, Y, 2005) |
| "Refractory septic shock has dismal prognosis despite aggressive therapy." | ( Gil-Antón, J; Hernández, A; López-Herce, J; Rey, C; Rodríguez-Núñez, A, 2006) |
| "A vasodilatory septic shock-like state was produced by treatment with the nitric oxide (NO) donor, S-nitroso-N-acetylpenicillamine (SNAP), and the phosphodiesterase inhibitor, 3-isobutyl-1-methylxanthine (IBMX)." | ( Boyle, WA; Leone, M, 2006) |
| "Treatment of hemodynamic instability in septic shock often demands the administration of vasopressor agents, although these may have deleterious effects on microcirculatory homeostasis." | ( Boer, R; Ghofrani, HA; Grimminger, F; Lehner, M; Maring, D; Mayer, K; Pullamsetti, SS; Rosengarten, B; Schermuly, RT; Schudt, C; Seeger, W; Weissmann, N, 2006) |
| "In the three ELBW infants with non-septic shock, only a transient stabilization in mean arterial pressure with restoration of urine output was observed after AVP therapy (dosage, 0." | ( Baghai, A; Gortner, L; Gottschling, S; Meyer, S; Wurm, D, 2006) |
| "In this clinically relevant septic shock model, alkaline phosphatase administration improved gas exchange, decreased interleukin-6 concentrations, and prolonged survival time." | ( Brands, R; Bruhn, A; Cai, Y; Raaben, W; Su, F; Verdant, C; Vincent, JL; Wang, Z; Wulferink, M, 2006) |
| "In catecholamine-dependent septic shock patients managed with systematic glucocorticoid therapy the results of ACTH stimulation do not predict hemodynamic improvement." | ( Bertrand, JC; Charier, D; Diconne, E; Donati, Y; Frere-Meunier, D; Guyomarc'h, S; Liotier, J; Morel, J; Papazian, L; Souweine, B; Venet, C; Zeni, F, 2006) |
| "In the untreated septic shock group, the mean arterial pressure and survival rate were markedly decreased (P<0." | ( Dai, DZ; Dai, Y; He, HB, 2006) |
| "The histological changes induced by endotoxin shock were not ameliorated by the administration of NOS inhibitors but instead appeared to be exacerbated to some degree." | ( Deguchi, Y; Fukuda, M; Imamura, Y; Miyoshi, N; Nakagawa, T; Soga, Y; Suga, H; Suzuki, T, 2006) |
| "Out of a cohort of 89 patients with septic shock, 14 patients treated with fluid and norepinephrine had inappropriate mixed venous oxygen saturation (SvO2<70%) not responding to correction of hypoxemia and anemia (>8 g." | ( Albanèse, J; Antonini, F; Boulos, E; Boyadjiev, I; Leone, M; Martin, C; Visintini, P, 2006) |
| "In early hyperdynamic septic shock, the administration of high-dose AVP as a single agent fails to increase mean arterial pressure in the first hour but maintains it above 70mmHg in two-thirds of patients at 48h." | ( Lamarre, P; Lauzier, F; Lesur, O; Lévy, B, 2006) |
| "The first aim of treating septic shock should be restoring the organ blood supply, and based on volume resuscitation, dopamine, noradrenaline and other vasoactive drugs could be combined to maintain circulatory stability." | ( Bai, XG; Chen, M; Chen, SY; Hou, LC; Hu, WN; Huo, TT; Ji, GL; Wang, C; Wang, YL; Xiong, LZ, 2006) |
| "Current therapies of sepsis and septic shock require administration of a large volume of fluid to maintain hemodynamic stability." | ( Adolphs, J; Brell, B; Dávid, I; Dorenberg, M; Hippenstiel, S; Schmeck, B; Suttorp, N; Temmesfeld-Wollbrück, B, 2007) |
| "One hundred thirty-seven patients with septic shock treated with norepinephrine with or without vasopressin." | ( Hollands, JM; Kollef, MH; Micek, ST; Shah, P; Shah, RA; Shannon, WD, 2007) |
| "In the septic shock model, all three drugs given preventively markedly decreased circulating levels of TNF-alpha and mortality (50% mortality in fluoxetine treated group, 30% in desipramine and prednisolone treated groups versus 90% in controls)." | ( Bichon, F; Detoc, M; Henriquet, C; Jaffuel, D; Mathieu, M; Michel, A; Portet, K; Roumestan, C, 2007) |
| "We reviewed 159 septic shock patients admitted to our intensive care unit (ICU) over a 40-month period to study the association between induction agent and clinical outcome, including vasopressor, inotrope, and steroid therapy." | ( McKeown, DW; Ray, DC, 2007) |
| "standard therapy for severe sepsis and septic shock patients." | ( Childs, EW; Jacobsen, G; Kruse, JA; Loomba, M; Otero, R; Rivers, EP; Shah, K, 2007) |
| "In patients with septic shock stress doses of HC exert beneficial effects in terms of improvements in hemodynamics, decrease in pro-inflammatory mediators, and oxidative stress without the compromise of opsonization-dependent phagocytic neutrophil functions; thus, HC treatment does not aggravate non-specific immunosuppression but instead improves innate immunity in the early stage of septic shock." | ( Briegel, J; Chouker, A; Hoelzl, A; Hummel, T; Kaufmann, I; Schelling, G; Schliephake, F; Thiel, M, 2008) |
| "We have developed a septic shock model in mice by sequential administration of beta-glucan, a biological response modifier, and indomethacin (IND), a nonsteroidal anti-inflammatory drug." | ( Adachi, Y; Miura, NN; Nameda, S; Ohno, N, 2007) |
| "The improved survival of mice after endotoxic shock could still be observed when atropine was administered several hours after LPS injection." | ( Fuentes, JM; Fulton, WB; Maio, AD; Nino, D; Talamini, MA, 2008) |
| "Thus, guidelines for septic shock recommend early goal-directed therapy (EGDT) during the first six hours of treatment." | ( Goto, K; Hidaka, S; Kusaka, J; Noguchi, T; Oyama, Y; Shingu, C; Yamamoto, S, 2008) |
| "Emphasis in therapy of human septic shock is shifting towards reliable end points and predictors of survival." | ( Benchekroune, S; Berton, C; Chaara, M; Karpati, PC; Laisné, MJ; Mateo, J; Mebazaa, A; Nathan, C; Payen, D; Riché, F, 2008) |
| "10 patients with severe sepsis/septic shock (median APACHE II score: 27, hospital mortality 40%) were treated with PSA on 5 consecutive days." | ( Frank, H; Heemann, U; Huber, W; Kreymann, B; Lutz, J; Reindl, W; Ronco, C; Schmid, RM; Umgelter, A, 2008) |
| "This is a review of the management of septic shock that suggests an approach to treatment (ABCDEF: Airway, Breathing, Circulation, Drugs, Evaluate the source of sepsis, Fix the source of sepsis) for clinicians." | ( Russel, JA, 2008) |
| "In patients with community-acquired septic shock, our data suggest that norepinephrine administration could be associated with worse outcome." | ( Carneiro, AH; Pereira, AC; Póvoa, PR; Ribeiro, OS, 2009) |
| "In patients who had septic shock and were also treated with corticosteroids, vasopressin, compared to norepinephrine, was associated with significantly decreased mortality (35." | ( Cook, DJ; Cooper, DJ; Gordon, AC; Granton, JT; Hébert, PC; Holmes, CL; Mehta, S; Presneill, JJ; Russell, JA; Singer, J; Storms, MM; Walley, KR, 2009) |
| "We used an experimental model of endotoxic shock induced by LPS in mice in which the animals were pre-treated with ozone/oxygen mixture for 5 days (once daily), with injection of LPS 24 h thereafter to induce endotoxic shock." | ( Alonso, Y; Alvarez, RG; Borrego, A; Delgado, R; Schulz, S; Zamora, ZB, 2009) |
| "In a septic shock population, we tested the hypotheses that etomidate administration induces more non-responders to corticotropin and increases mortality and that hydrocortisone treatment decreases mortality in patients receiving etomidate." | ( Annane, D; Chevret, S; Cuthbertson, BH; Freivogel, K; Garfield, M; Goodman, S; Laterre, PF; Payen, D; Reinhart, K; Singer, M; Sprung, CL; Vincent, JL; Weiss, YG, 2009) |
| "Seventy-seven septic shock patients with hypotension refractory to fluids and administration of norepinephrine were randomly divided into control and treatment groups." | ( Gan, Q; Hu, B; Li, JG; Li, L; Liang, H; Liu, C; Luo, Y; Yu, Z; Zhou, Q, 2009) |
| "To evaluate the values of dopamine in treating endotoxic shock by observing the changes in the pulmonary artery pressure (PAP) during the treatment." | ( Tao, BD; Zhang, BJ; Zhang, J, 2009) |
| "In patients with severe sepsis or septic shock, Surviving Sepsis Campaign clearly recommends administering anticoagulation in the absence of specific contraindications." | ( Fries, D, 2009) |
| "Forty early septic shock patients were included in the study and administered either the loading dose infusion of propofol (n = 20, group P) of 1 mg/kg over 15 minutes followed by a maintenance dose of 1 to 3 mg/kg per hour (n = 20, group P), or a loading dose of dexmedetomidine 1 microg/kg over 10 minutes followed by a maintenance of 0." | ( Kargi, M; Memiş, D; Sut, N, 2009) |
| "Thirty-six patients with severe sepsis/septic shock and sepsis-associated immunosuppression (assessed using monocytic human leukocyte antigen-DR (mHLA-DR) expression) were assessed in a controlled trial of GM-CSF or placebo treatment for 8 days." | ( Fotopoulou, C; Fusch, G; Hammoud, B; Hasper, D; Meisel, C; Pschowski, R; Reinke, P; Schefold, JC; Schütt, C; Volk, HD; Von Haehling, S; Zeden, JP, 2010) |
| "Among patients with septic shock who were treated to normalize central venous and mean arterial pressure, additional management to normalize lactate clearance compared with management to normalize ScvO2 did not result in significantly different in-hospital mortality." | ( Arnold, RC; Claremont, HA; Jones, AE; Kline, JA; Shapiro, NI; Trzeciak, S, 2010) |
| "Twenty-nine septic shock patients who were poorly responsive to fluid therapy and vasopressors were studied." | ( Leemingsawat, C; Permpikul, C; Promsin, P; Ratanarat, R; Srivijitkamol, A, 2010) |
| "In an animal model of severe septic shock, this study compared the effects of HDI treatment to normal saline (NS) resuscitation alone." | ( Barringer, KW; Dries, DJ; Flottemesch, TJ; Holger, JS; Marini, JJ; Peake, BJ, 2010) |
| "Twenty patients, suffering from septic shock, admitted to the intensive care unit (ICU) from December, 2008 to June, 2009, were randomly divided into treatment group and control group." | ( Liu, HT; Wang, HL; Yu, KJ, 2010) |
| "After the onset of septic shock, chronically instrumented sheep were randomly assigned to receive first-line treatment with the selective V(2)R-antagonist (1 μg/kg per hour), AVP (0." | ( Dünser, M; Ertmer, C; Kampmeier, TG; Lange, M; Lipke, E; Morelli, A; Rehberg, S; Strohhäcker, AK; Traber, DL; Van Aken, H; Westphal, M; Whorton, E, 2010) |
| "We report furthermore an infant with septic shock and on treatment with β-blockers in whom terlipressin normalized blood pressure." | ( Catarzi, S; Daniotti, M; Filippi, L; Fiorini, P; Gozzini, E; Pagliai, F, 2011) |
| "Early goal-directed therapy for septic shock, however, attempts to balance O2 delivery and demand by optimizing cardiac function and hemoglobin concentration, without making use of hyperoxia." | ( Asfar, P; Ballestra, C; Calzia, E; Georgieff, M; Hauser, B; Matejovic, M; Radermacher, P, 2010) |
| "However, the use of MB infusions in septic shock is not considered standard treatment, and the available literature describes infusions of short duration, typically less than six hours." | ( Dumbarton, TC; Green, R; Minor, S; Yeung, CK, 2011) |
| "Classically septic shock treatment takes into consideration only systemic parameters but failure in retaining arteriolar blood flow and functional capillary density (FCD) during sepsis worsens the outcome." | ( Bouskela, E; Furtado, ES; Santos, AO; Villela, NR, 2011) |
| "In patients suffering from septic shock levosimendan treatment decreased oxidative burst activity in unstimulated, fMLP and PMA stimulated PMN by 48% (P < 0." | ( Bellmann, R; Bertocchi, C; Bijuklic, K; Dunzendorfer, S; Hasslacher, J; Joannidis, M; Kountchev, J, 2011) |
| "Sixty-four adult inpatients with septic shock (26 medical intensive care unit and 38 surgical intensive care unit) who required vasopressor administration including vasopressin therapy were included." | ( Alaniz, C; Kraft, MD; Miller, JT; Welage, LS, 2012) |
| "We analyzed 30 patients with septic shock who were treated in an intensive care unit." | ( Inal, MT; Memiş, D; Sut, N, 2012) |
| "Thirteen patients in septic shock for less than 48 hours who required NE administration were included." | ( Creteur, J; De Backer, D; Donadello, K; Favory, R; Salgado, DR; Taccone, FS; Thooft, A; Vincent, JL, 2011) |
| "In an endotoxic shock model, awara pulp oil treatment decreased pro-inflammatory cytokines and increased anti-inflammatory cytokines." | ( Bony, E; Boudard, F; Brat, P; Dussossoy, E; Giaimis, J; Michel, A; Portet, K; Poucheret, P, 2012) |
| "Vasopressor therapy is required in septic shock to maintain tissue perfusion in the face of hypotension." | ( Cheng, ZQ; Gotes, J; Jacobs, H; Kasian, K; Mink, SN, 2012) |
| "In patients with septic shock, dopamine administration is associated with greater mortality and a higher incidence of arrhythmic events compared to norepinephrine administration." | ( Aldecoa, C; De Backer, D; Njimi, H; Vincent, JL, 2012) |
| "In the in vivo model of lethal toxic shock syndrome (TSS) in HLA-DR3 transgenic mice, two of these antibodies conferred significant partial protection when administered individually, but offered complete protection in a synergistic manner when given together." | ( Goldsby, RA; Kwan, A; Margulies, DH; Natarajan, K; Osborne, BA; Quinn, M; Rajagopalan, G; Tilahun, AY; Tilahun, ME; Xie, C, 2011) |
| "A patient with septic shock due to extensively drug resistant (XDR) Pseudomonas aeruginosa was cured by optimizing the meropenem (MEM) regimen to obtain at least 40% of the time between two administrations in which drug levels were four times higher than the MIC of the pathogen." | ( Cotton, F; Jacobs, F; Roisin, S; Taccone, FS; Vincent, JL, 2012) |
| "Treatment of septic shock varies across hospitals." | ( Lagu, T; Lindenauer, PK; Nathanson, BH; Pekow, PS; Rothberg, MB; Steingrub, JS, 2012) |
| "A total of 48 pediatric cases with septic shock, in whom 6 hours, conventional treatment could not reverse shock from January 2008 to December 2010, were selected for this study." | ( Fu, LM; Hu, YP; Lei, SB; Li, JF; Liu, JH; Wu, Y; Yang, ZJ, 2011) |
| "The Corticosteroid Therapy of Septic Shock trial had a large impact on survey respondents, with 62% reporting a practice change." | ( Anderegg, BA; Bruno, JJ; Dee, BM; Hernandez, M; Pravinkumar, SE, 2012) |
| "Vasopressin treatment in septic shock is associated with a significant reduction in heart rate but no change in cardiac output or other measures of perfusion." | ( Ashby, D; Gordon, AC; Russell, JA; Walley, KR; Wang, N, 2012) |
| "We identified 144 children with septic shock treated with noradrenaline, in 22% as the first-line drug." | ( Botte, A; Cremer, R; Lampin, ME; Leclerc, F; Rousseaux, J; Sadik, A, 2012) |
| "Besides animal model of septic shock and a small cohort of septic patients, these benefits have not been studied in septic shock patients who require norepinephrine administration." | ( Balik, M; Bartakova, H; Korinek, J; Leden, P; Otahal, M; Rulisek, J; Zakharchenko, M, 2012) |
| "Rats were divided into control, septic shock, and carnosine-treated septic shock groups." | ( Burukoğlu, D; Oter, S; Sahin, S; Sutken, E, 2013) |
| "Rats exposed to septic shock and treated with carnosine exhibited decreased sinusoidal dilatation and cellular inflammation into the portal region, compared to the sepsis group; the livers of rats in this group had near-normal histological structure." | ( Burukoğlu, D; Oter, S; Sahin, S; Sutken, E, 2013) |
| "We investigated, in a rat model of endotoxic shock, the effects of omega-3 PUFAs pretreatment on cardiac hemodynamics, function, and oxidative stress as well as intestinal barrier." | ( Coëffier, M; Coquerel, D; Dechelotte, P; Kušíková, E; Mulder, P; Renet, S; Richard, V; Tamion, F; Thuillez, C, 2013) |
| "Eighty children with septic shock treated with bundle treatment in Department of Critical Care Medicine were retrospectively analyzed." | ( Cao, LJ; Geng, WJ; Guo, YM; Huo, XM; Kang, L; Li, JE; Li, P; Shi, HY; Shi, XN; Sun, H; Wang, XD; Xu, MX, 2013) |
| "During septic shock, vasopressors are a cornerstone of therapy." | ( Chapelier, K; Cividjian, A; Dantony, E; Geloen, A; May, CN; Quintin, L; Rabilloud, M, 2013) |
| "Patients with septic shock who needed continuous blood pressure monitoring and high-dose NE therapy 0." | ( Hong, SB; Huh, JW; Jun, JH; Kim, WY; Koh, Y; Lim, CM, 2013) |
| "Patients with septic shock in ICUs with a high proportion of RRT had more severe organ dysfunctions and received more organ-supportive treatments." | ( Ala-Kokko, TI; Karlsson, S; Kaukonen, KM; Korhonen, AM; Koskenkari, J; Laurila, JJ; Lund, V; Pettilä, V; Poukkanen, M; Vaara, ST, 2014) |
| "After endotoxic shock was induced by intravenous lipopolysaccharide administration for 30 min, rats in the NE and TP groups were infused with saline 5 mL/kg/h and simultaneously given NE 4 μg/kg/min or TP 8 μg/kg/h." | ( Huang, Y; Qiu, H; Qiu, X; Xu, J; Yang, Y, 2014) |
| "Early goal-directed therapy (EGDT) in septic shock defined by Rivers et al was proven to reduce mortality and validated by observational studies." | ( Boghi, D; Cazzaniga, M; Coen, D; Cortellaro, F; Montalbetti, L; Pasini, S; Tombini, V; Vaccaro, A, 2014) |
| "Prospective study in patients with septic shock treated with low doses of hydrocortisone." | ( Antonopoulou, AN; Apostolidou, EN; Dimopoulou, I; Ioakeimidou, A; Kalpakou, GT; Katsenos, CS; Lekkou, AA; Mandragos, KE; Mpalla, MC; Papanikolaou, MN; Paraschos, MD; Patrani, MA; Pistiki, AC; Pratikaki, ME; Retsas, TA; Routsi, C; Savva, AA; Vassiliagkou, SD, 2014) |
| "Over a 2-year period, 170 patients with septic shock treated with low doses of hydrocortisone were enrolled." | ( Antonopoulou, AN; Apostolidou, EN; Dimopoulou, I; Ioakeimidou, A; Kalpakou, GT; Katsenos, CS; Lekkou, AA; Mandragos, KE; Mpalla, MC; Papanikolaou, MN; Paraschos, MD; Patrani, MA; Pistiki, AC; Pratikaki, ME; Retsas, TA; Routsi, C; Savva, AA; Vassiliagkou, SD, 2014) |
| "IN the presence of septic shock, every hour in delaying the administration of effective antibiotics is associated with a measurable increase in mortality." | ( Chen, H; Liu, DW; Long, Y; Wang, XT; Zhang, HM, 2014) |
| "Patients with severe sepsis and septic shock with ≥2 organ failures not responding to volume resuscitation and vasopressor infusion were treated with CPFA within 8 h of admission to the intensive care unit." | ( Agbedjro, A; Berlot, G; Bianco, F; Gerini, U; Giudici, F; Tomasini, A; Viviani, M, 2014) |
| "The presence of septic shock and prescription of continuous renal replacement therapy introduces further complexities for the clinician." | ( Roberts, DM; Roberts, JA, 2014) |
| "In addition, in a septic shock model of mice intraperitoneally injected with lipopolysaccharide (LPS), prophylactic treatment with CO protected animals from hypothermia, weight loss, mobility loss and death." | ( Bueno, SM; Kalergis, AM; Riquelme, SA, 2015) |
| "Among patients with septic shock treated with EGDT in the setting of subnormal ScvO2 values despite meeting CVP and MAP target goals, treatment with RBC transfusion may be independently associated with decreased in-hospital mortality." | ( Ballard, DW; Elms, AR; Hung, YY; Kene, MV; Liu, V; Mark, DG; Morehouse, JW; Vinson, DR, 2014) |
| "In Wistar rats, septic shock developed with hypotension, tachycardia, and myocardial and hepatic dysfunction at 4 h following LPS administration (10 mg/kg, i." | ( Dai, ZK; Hsu, JH; Lin, SJ; Liou, SF; Wu, JR; Yang, RC; Yeh, JL, 2014) |
| "Twelve septic shock patients with acute kidney injury (AKI) undergoing RRT [continuous venovenous hemodiafiltration (CVVHDF) n = 7, coupled-plasma filtration adsorption-HF (CPFA-HF) n = 4, hemoperfusion n = 1] treated with colistin methanesulfonate at a dose of 4." | ( Biancone, L; Carignano, P; Leporati, M; Mariano, F; Stella, M; Vincenti, M, 2015) |
| "Forty-three septic shock patients who were undergoing early goal-directed therapy resuscitated within 24 h were enrolled." | ( Guo, F; Huang, Y; Li, Q; Liu, L; Peng, X; Qiu, H; Yang, Y; Yu, T, 2015) |
| "Forty-one patients with septic shock in accordance with early goal directed treatment and met the target within 6 hours, and admitted to intensive care unit (ICU) of Affiliated Huxi Hospital of Jining Medical College from January 2012 to January 2014 were enrolled." | ( Hou, B; Liu, J; Liu, Z; Shi, Q; Yang, S; Yang, W; Zhang, G, 2014) |
| "After septic shock was confirmed, the animals were left untreated until cardiac arrest occurred." | ( Chalkias, A; Kouskouni, E; Koutsovasilis, A; Papalois, A; Spyropoulos, V; Xanthos, T, 2015) |
| "In this clinically relevant model of septic shock induced by fecal peritonitis, the administration of levosimendan had beneficial effects on haemodynamic variables, liver and kidney dysfunction, and metabolic acidosis." | ( Chen, SJ; Huang, HC; Ka, SM; Li, KY; Liaw, WJ; Tsao, CM; Wu, CC, 2014) |
| "Fourteen septic shock patients admitted to the Peking University Third Hospital were included in the study, and each patient received 30 mg papaverine, which is the approximate dosage used to treat a conventional arterial spasm." | ( Li, H; Wang, Z; Yao, G; Zhu, X, 2015) |
| "Fifty-one patients with septic shock were studied within the first 4 hours of norepinephrine administration." | ( Conrad, M; Levy, B; Perez, P; Thivilier, C, 2015) |
| "Seventy-nine septic shock patients were assigned to the treatment, with 41 in control group, and 38 in research group." | ( Chen, Z; He, H; He, Z; Yang, C, 2015) |
| "In patients with severe sepsis and septic shock, levosimendan is associated with a significant reduction in mortality compared with standard inotropic therapy." | ( Bignami, E; De Luca, M; Di Tomasso, N; Frau, G; Landoni, G; Likhvantsev, V; Lomivorotov, V; Monaco, F; Oriani, A; Putzu, A; Zangrillo, A, 2015) |
| "During the early stage of septic shock-induced ARDS, dobutamine treatment demonstrated a beneficial effect by relieving pulmonary edema in patients, without a negative elevation in preload or hemodynamics, which might account for the improvements in ventilator function and tissue hypoperfusion." | ( Dai, J; Du, M; Guo, C; Rao, Z; Sun, G; Tang, R; Wang, W; Wang, Y; Xu, F; Zhou, M, 2016) |
| "Treatment of severe septic shock was initiated with fluid resuscitation, inotropic support, sedation, and paralysis." | ( Benner, K; Brown, B; Hayes, L; Prabhakaran, P; Rutledge, C, 2015) |
| "52 consecutive patients treated for septic shock in the intensive care unit of one centre (Marien Hospital Herne, Ruhr University Bochum, Germany) were prospectively enrolled in this study." | ( Butz, T; Christ, M; Liebeton, J; Prull, MW; Sasko, B; Trappe, HJ, 2015) |
| "Here we report the case of a septic shock patient treated with TPE and review the available literature with respect to TPE as an adjunctive therapy in sepsis." | ( David, S; Hoeper, MM; Kielstein, JT, 2017) |
| "She was diagnosed with septic shock and treated with norepinephrine 10 days ago." | ( Lee, NH; Roh, SG; Shin, JY; Yang, KM, 2016) |
| "Administration of steroids and septic shock are associated with poor prognosis." | ( Cai, H; Shen, Q; Shen, Y; Yang, Q; Zhang, Y; Zhou, H; Zhou, J, 2016) |
| "Totally 50 patients with septic shock were assigned to the control group and the treatment group according to random digit table, 25 cases in each group." | ( Xie, RF, 2016) |
| "Severe sepsis, septic shock and bacteremia are critical illnesses, and patients with these conditions require close monitoring and immediate medical treatment." | ( Kingnakom, A; Wiwatcharagoses, K, 2016) |
| "In conclusion, in an ovine model of septic shock, administration of HTL was associated with earlier onset impaired tissue perfusion and shorter survival time." | ( Creteur, J; Donadello, K; He, X; Hosokawa, K; Orbegozo, D; Post, EH; Su, F; Taccone, FS; Vincent, JL; Xie, K, 2016) |
| "Patients presenting septic shock were rapidly administered one of two regimens of hydrocortisone, either a 50-mg intravenous bolus every 6 h during 7 days (200-mg group; n = 59) or a 100-mg initial bolus followed by a continuous infusion of 300 mg daily for 5 days (300-mg group; n = 63)." | ( Barel, R; Bernardin, G; Césari-Giordani, JF; Dellamonica, J; Freche, A; Gentilhomme, A; Goubaux, B; Hyvernat, H; Kaidomar, M; Pradier, C, 2016) |
| "SV of septic shock patients is increased following esmolol therapy." | ( Du, W; Liu, DW; Long, Y; Wang, XT, 2016) |
| "This study shows that the development of endotoxic shock is accompanied by increased levels of NO in the liver, lungs, kidneys, heart; administration of the SOD-CHS-CAT conjugate insignificantly influenced this parameter." | ( Abramov, AA; Lakomkin, VL; Maksimenko, AV; Timoshin, AA; Vavaev, AV; Vavaeva, AV; Zvyagintseva, MA, 2016) |
| "In patients with septic shock, the present evidence does not support goal-directed therapy using venous oxygen saturation during early resuscitation." | ( Chemtob, RA; Eskesen, TG; Moeller-Soerensen, H; Perner, A; Ravn, HB, 2016) |
| "Vasopressors used in the treatment of septic shock, including norepinephrine, are dosed using weight-based (WB) or non-weight-based (NWB) strategies." | ( Droege, CA; Ernst, NE, 2017) |
| "Among patients with septic shock in US hospitals affected by the 2011 norepinephrine shortage, the most commonly administered alternative vasopressor was phenylephrine." | ( Gershengorn, HB; Hua, M; Rubenfeld, G; Vail, E; Walkey, AJ; Wunsch, H, 2017) |
| "The ability of MOx to detect even mild septic shock has meaningful implications for emergency care, where decisions about triage and therapy must be made quickly and accurately." | ( Arakaki, LSL; Asplund, KM; Bulger, EM; Carlbom, DJ; Ciesielski, WA; Fisk, DM; Schenkman, KA; Shaver, JM; Sheehan, KL, 2017) |
| "We showed endotoxic shock was reversed and all mice survived with a CS administration at a dosage of 2mg/day for 3 days, in comparison to survival rate with saline administration (p≤0." | ( Akasaka, Y; Haque, A; Ishii, Y; Matsumoto, T; Tateda, K, 2017) |
| "Elderly patients with septic shock treated with norepinephrine displayed a better survival in the ward and at 30 days than expected." | ( Åstrand, P; Barle, H; Eksborg, S; Frostell, C; Hallengren, M, 2017) |
| "According to the new definition of septic shock, vasopressor therapy and hyperlactatemia are essential for diagnosis." | ( Choi, JY; Jeong, SJ; Jeong, WY; Jung, IY; Kim, EJ; Kim, JM; Kim, MH; Kim, YC; Ku, NS; Oh, DH; Song, JE; Song, YG, 2019) |
| "Clear definitions for septic shock assist clinicians regarding recognition, treatment and standardized reporting of characteristics and outcome of this entity." | ( Driessen, RGH; Mol, MF; Schnabel, RM; van de Poll, MCG; van Mook, WNKA, 2018) |
| "Adult patients with septic shock and conserved renal function, treated with meropenem, were eligible for inclusion." | ( Alobaid, AS; Lipman, J; Perner, A; Roberts, JA; Sjövall, F; Wallis, SC, 2018) |
| "In patients with septic shock and possible augmented renal clearance, doses should be increased and/or administration should be performed by prolonged or continuous infusion to increase the likelihood of achieving therapeutic drug concentrations." | ( Alobaid, AS; Lipman, J; Perner, A; Roberts, JA; Sjövall, F; Wallis, SC, 2018) |
| "Patients with septic shock were treated by one of two hydrocortisone regimens: either a 50-mg intravenous bolus every 6 h during 7 days (200 mg group; n = 49), or a 100-mg initial bolus followed by a continuous infusion of 300 mg daily for 5 days (300 mg group; n = 50)." | ( Barel, R; Bernardin, G; Dellamonica, J; Doyen, D; Goubaux, B; Hyvernat, H; Kaidomar, M; Panaïa-Ferrari, P; Pradier, C, 2018) |
| "To compare the hemodynamic response in septic shock patients receiving vasopressin who were on chronic renin-angiotensin-aldosterone system inhibitor therapy with those who were not." | ( Barker, AB; Denaburg, MA; Erwin, BL; McArdle, PJ; Morgan, CJ; Windham, ST, 2017) |
| "Medical and surgical ICU patients with septic shock who received vasopressin infusion added to at least one concomitant vasopressor agent between January 2014 and December 2015, then divided into two cohorts: 1) patients who were on chronic renin-angiotensin-aldosterone system inhibitor therapy as outpatients and 2) patients who were not on chronic renin-angiotensin-aldosterone system inhibitor therapy as outpatients." | ( Barker, AB; Denaburg, MA; Erwin, BL; McArdle, PJ; Morgan, CJ; Windham, ST, 2017) |
| "The key to the treatment of septic shock is to provide adequate oxygen supply and improve tissue perfusion." | ( Xu, D; Xu, LY, 2017) |
| "Treatment with DTNB 12h after septic shock induction reversed the loss of response of aorta rings and blood pressure to vasoconstrictors, reduced organ damage and protein nitrosylation and increased survival to 80%." | ( Assreuy, J; Benedet, PO; Gonçalves, MC; Menegatti, ACO; Terenzi, H, 2018) |
| "Patients with culture-negative septic shock behave similarly to those with culture-positive septic shock in nearly all respects; early appropriate antimicrobial therapy appears to improve mortality." | ( Bilgili, B; Kethireddy, S; Kirchner, HL; Kumar, A; Layon, AJ; Light, RB; Maki, D; Mirzanejad, Y; Ofoma, UR; Parrillo, JE; Sees, A, 2018) |
| "In patients with septic shock for no longer than 48 h, administration of vasopressin is likely to result in an improvement in microcirculation when the baseline noradrenaline dose is higher than 0." | ( Azevedo, LCP; Bafi, AT; Bakker, J; Freitas, FGR; Ladeira, RT; Lima, A; Machado, FR; Nascente, APM, 2017) |
| "In patients recovering from septic shock treated with concomitant AVP and NE, no significant difference was noted in the incidence of hypotension based on discontinuation order of these agents." | ( Bauer, SR; Duggal, A; Lam, SW; Reddy, AJ; Sacha, GL; Torbic, H, 2018) |
| "A 56-year-old woman with septic shock presented with persistent hyperlactatemia, despite an adequate clinical response to treatment." | ( Brindamour, D; Demers-Marcil, S; Dupuis, S; Fortier, M; Hogan, P; Lagrenade-Verdant, C; Plourde, R, 2020) |
| "Norepinephrine as Initial Therapy in Septic Shock])." | ( Al-Beidh, F; Antcliffe, DB; Ashby, D; Brett, SJ; Burnham, KL; Gordon, AC; Hinds, CJ; Knight, JC; Santhakumaran, S, 2019) |
| "Adult patients with septic shock treated with ciprofloxacin were eligible for inclusion." | ( Alobaid, AS; Lipman, J; Perner, A; Roberts, JA; Sjövall, F; Wallis, SC, 2019) |
| "In patients with septic shock, standard ciprofloxacin dosing achieved concentrations to successfully treat bacteria with MICs ≤0." | ( Alobaid, AS; Lipman, J; Perner, A; Roberts, JA; Sjövall, F; Wallis, SC, 2019) |
| "We have constructed a model of septic shock and have shown that it can reproduce well the time courses of treatment and disease progression." | ( Akashi, M; Kimura, H; Shimamoto, S; Shimoda, S; Uchida, K; Watanabe, Y; Yaguchi, A; Yamada, H; Yamanaka, Y; Yamashita, M, 2019) |
| "Children with meningococcal septic shock (1 month to 18 years) included in this study received cefotaxime 100-150 mg/kg/day as antibiotic treatment." | ( Boeddha, NP; de Wildt, SN; Donders, R; Driessen, GJ; Ekinci, E; Hartman, SJF; Hazelzet, JA; Koch, BCP, 2019) |
| "Patients with septic shock in whom norepinephrine (NE) infusion alone is insufficient to raise blood pressure require the concomitant administration of vasopressin (VP)." | ( Huang, L; Huang, Y; Qiu, H; Wu, Z; Xie, J; Xu, J; Yang, Y; Zhang, S, 2020) |
| "In adults with septic shock treated with concomitant VP and NE therapy, discontinuing VP first may lead to a higher incidence of hypotension but is not associated with mortality or ICU LOS." | ( Huang, L; Huang, Y; Qiu, H; Wu, Z; Xie, J; Xu, J; Yang, Y; Zhang, S, 2020) |
| "Vasopressin therapy in septic shock had no effect on 28-day mortality although the confidence intervals are wide." | ( Ashby, D; Brett, SJ; Gordon, AC; Hajjar, L; Mason, AJ; Nagendran, M; Perkins, GD; Russell, JA; Walley, KR, 2019) |
| "Treatment of pediatric septic shock with thiamine was followed by rapid improvement in physiologic and clinical outcomes after prolonged hyperlactatemia." | ( Berg, RA; Blowey, B; Fitzgerald, JC; Ganetzky, R; Keele, L; Murali, CN; Sutton, RM; Weiss, SL, 2019) |
| "Patients who developed septic shock treated with at least one vasopressor and whose absolute neutrophil count was < 1000 cells/μL were included." | ( Han, M; Hong, SB; Huh, JW; Kang, J; Koh, Y; Lim, CM, 2019) |
| "In cancer patients with septic shock, vasopressin as first-line vasopressor therapy was not superior to norepinephrine in reducing 28-day mortality rate." | ( Belletti, A; de Almeida, JP; Dos Santos Neto, NC; Filho, RK; Fukushima, JT; Galas, FRBG; Gordon, AC; Hajjar, LA; Landoni, G; Oliveira, G; Park, CHL; Rizk, SI; Szeles, TF; Zambolim, C, 2019) |
| "Albumin-based fluid therapy in septic shock is a matter of debate and criticism." | ( Davari, M; Jahangard-Rafsanjani, Z; Kebriaeezadeh, A; Mojtahedzadeh, M; Najmeddin, F; Sadeghi, K; Tigabu, BM, 2019) |
| "Sepsis and septic shock are major causes of morbidity and mortality worldwide, associated with a high economic and social burden on healthcare systems and communities, yet with few definite treatment modalities." | ( Al Kurdi, MH; Aletreby, WT; Alharthy, AM; Alodat, MA; Alzayer, W; Farrag, HA; Hamido, HM; Huwait, BM; Karakitsos, D; Madi, AF; Mahmood, NN; Mumtaz, SA; Ramadan, OE; Soliman, IR, 2019) |
| "Adult patients with septic shock were included if they were treated with fixed-dose vasopressin as an adjunct to catecholamines for at least 3 hours." | ( Abraham, S; Ammar, MA; Bauer, SR; Culver, DA; Lam, SW; Olman, MA; Sacha, GL; Scheraga, RG; Torbic, H; Yerke, JR, 2020) |
| "Mortality rate for septic shock, despite advancements in knowledge and treatment, remains high." | ( Colon Hidalgo, D; Masic, D; Park, D; Patel, J; Rech, MA, 2020) |
| "Twenty-one patients with septic shock enrolled in a randomised trial of high dose vitamin C therapy in septic shock." | ( Abdelhamid, YA; Bellomo, R; Bitker, L; Collie, JT; Deane, AM; Doherty, S; Eastwood, G; Fujii, T; Greaves, RF; Hudson, EP; Luethi, N; Naorungroj, T; Udy, AA; Yanase, F, 2019) |
| "In patients with septic shock, treatment with intravenous vitamin C, hydrocortisone, and thiamine, compared with intravenous hydrocortisone alone, did not significantly improve the duration of time alive and free of vasopressor administration over 7 days." | ( Al-Bassam, W; Bailey, M; Bates, S; Bellomo, R; Bitker, L; Cioccari, L; Deane, AM; Dwivedi, DB; Eastwood, GM; Edney, SJ; Frei, DR; French, CJ; Fujii, T; Hajjar, LA; Hudson, EP; Hunt, AL; Judd, HL; Luethi, N; McCracken, P; McGain, F; Naorungroj, T; Oliveira, G; Orford, N; Orosz, J; Peppin, C; Shehabi, Y; Udy, AA; Yanase, F; Young, PJ, 2020) |
| "Patient were treated initially for septic shock, later diagnosed as thyroid storm and was treated with oral carbimazole, propanolol and digoxin." | ( Keyal, NK; Khanal, S; Pokharel, N, 2020) |
| "Critically ill patients with septic shock often receive multiple intravenous medications, necessitating either the placement of separate lines for medication administration or administration of medications concurrently through a Y-site connector only where compatibility has been demonstrated." | ( Foushee, JA; Fox, LM; Meredith, P; Wilder, AG, 2020) |
| "For children with septic shock who do not reach the 6-hour initial recovery target and/or have a fluid overload of >10%, early CBP treatment can quickly control the disease, shorten the course of disease, and accelerate immune reconstruction." | ( Li, Z; Lu, GZ; Mo, WG; Mo, ZR; Tang, YP; Wei, R; Wei, Y; Xie, YJ, 2020) |
| "Mortality remains high in septic shock with few new treatment options." | ( Bui, AD; Guru, PK; Helgeson, SA; Sanghavi, DK, 2020) |
| "Patient characteristics and septic shock treatment courses were similar between groups." | ( Bauer, SR; Duggal, A; Lam, SW; Reddy, AJ; Sacha, GL, 2021) |
| "Similarly, compared with the toxic shock group, the expression of p-ERK1/2 protein in the dexmedetomidine treatment group was significantly decreased (p <0." | ( Li, GC; Li, ZB; Qin, J, 2021) |
| "To evaluate characteristics of septic shock patients treated with hydrocortisone (HC) due to suspicion of critical illness-related corticosteroid insufficiency (CIRCI) as compared to septic shock patients without suspicion of CIRCI." | ( Culler, C; Guillaumin, J; Summers, AM; Yaxley, PE, 2021) |
| "Patients with septic shock treated with L-AMB were identified from the Japanese Diagnosis Procedure Combination national database and were stratified according to L-AMB treatment initiation either at septic shock onset (early L-AMB group) or after the onset (delayed L-AMB group) to determine their survival rates following septic shock onset and the shock cessation period." | ( Izumikawa, K; Miyazaki, T; Nishino, T; Obata, Y; Ota, Y; Sato, K; Takahashi, A; Takazono, T; Tashiro, M; Wakamura, T, 2021) |
| "Early L-AMB administration at septic shock onset may be associated with early shock cessation." | ( Izumikawa, K; Miyazaki, T; Nishino, T; Obata, Y; Ota, Y; Sato, K; Takahashi, A; Takazono, T; Tashiro, M; Wakamura, T, 2021) |
| "Eligible septic shock patients who consented to participation in the study were randomly assigned to receive early lactate-guided treatment or regular treatment as controls." | ( Chen, H; Tong, F; Wang, X; Wang, Y; Xu, J, 2022) |
| "Among patients with sepsis and septic shock, a combination therapy of hydrocortisone, ascorbic acid, and thiamine, compared with placebo, could reduce the duration of vasopressor use and SOFA scores during the first 72 h." | ( Hu, B; Hu, C; Huang, W; Li, J; Wu, T; Xu, Q, 2021) |
| "Refractory septic shock in neonates is still associated with high mortality, necessitating an alternative therapy, despite all currently available treatments." | ( Allam, R; Awad, H; Ibrahim, M; Ismail, R; Shehata, B; Youssef, O, 2022) |
| "Thirty preterm neonates with refractory septic shock were randomized to receive either MB or TP as an adjuvant to conventional therapy." | ( Allam, R; Awad, H; Ibrahim, M; Ismail, R; Shehata, B; Youssef, O, 2022) |
| "Intravenous vitamin C administration in septic shock may have a sparing effect on vasopressor requirements, and vitamin C's enzyme cofactor functions provide a mechanistic rationale." | ( Carr, AC; Doyle, T; Mehrtens, J; Morgan, S; Morris, A; Rosengrave, P; Shaw, G; Spencer, E; Van Der Heyden, K; Williman, J, 2022) |
| "Hydrocortisone administration in septic shock remains controversial." | ( Chapman, M; Davies, ML; Meyer, EJ; Nenke, MA; Rankin, W; Rushworth, RL; Torpy, DJ, 2022) |
| "At admission, septic shock with purpura fulminans was diagnosed and required ICU hospitalization, invasive mechanical ventilation, vasopressor support and renal replacement therapy due to the rapid clinical deterioration." | ( Barraud, O; François, B; Garnier, F; Martins-Baltar, A; Meyer, S; Ploy, MC; Vignon, P, 2022) |
| "100 patients with septic shock treated in our institution from May 2019 to May 2021 were recruited and randomly assigned to receive either norepinephrine (control group) or norepinephrine plus ulinastatin (experimental group) according to the treatment scheme." | ( Chen, X; Guan, L; He, Y; Yu, X; Zhang, G, 2022) |
| "Gastric injury and septic shock administrated with Ca-EE were studied by H&E, PCR, and immunoblot." | ( Chen, H; Cho, JY; Hong, YH; Huang, L; Jang, J; Jeon, MJ; Kim, HG; Lee, BH; Lee, S; Lee, WS; Manilack, P; Shin, CY; Sounyvong, B; Yoon, JH; You, L, 2022) |
| "Three women developed septic shock due to neutropenic enterocolitis after irinotecan treatment, and 144 did not." | ( Gou, R; Horikawa, N; Inayama, Y; Ito, K; Kosaka, K; Nakatani, E; Tani, H; Tsuji, M; Umemiya, M; Yoshida, T; Yu, S, 2022) |
| "The main goal of septic shock therapy is to keep hemodynamic parameters in the normal range for adequate tissue perfusion." | ( Çeleğen, K; Çeleğen, M, 2022) |
| "Among adult patients with septic shock, early use of hydrocortisone, vitamin C, and thiamine combination therapy compared with placebo did not confer survival benefits." | ( Chen, QH; Gu, XH; Lyu, QQ; Shao, J; Yu, JQ; Zheng, RQ, 2022) |
| "All 26 patients who underwent DCS had septic shock, low mean arterial pressure (MAP) before the start of surgery, and required high-dose norepinephrine administration intraoperatively." | ( Ikegawa, H; Kajino, K; Kishimoto, M; Kuwagata, Y; Muroya, T; Nakamura, F; Onoe, A; Sakuramoto, K; Yui, R, 2022) |
| "Sepsis and septic shock are severe and difficult-to-treat conditions with high lethality." | ( Guedes, GV; Minicucci, MF; Tanni, SE, 2022) |
| "Patients who were diagnosed with sepsis/septic shock and treated with HA330 hemoperfusion adsorbent in addition to the standard treatment were included in this retrospective study conducted at Inonu University Turgut Ozal Medical Center between January 1, 2019 and January 1, 2021." | ( Aydogan, MS; Berber, I; Biçim, S; Erkurt, MA; Ince, V; Kaya, E; Keser, MF; Kose, A; Kuku, I; Memisoglu, F; Otan, E; Özer, AB; Özgül, M; Sarici, A, 2022) |
| "Patients who were diagnosed with sepsis/septic shock and treated with HA330 hemoperfusion adsorbent in addition to the standard treatment were included in this retrospective study conducted at Inonu University Turgut Ozal Medical Center between January 1, 2019 and January 1, 2021." | ( Aydogan, MS; Berber, I; Biçim, S; Erkurt, MA; Ince, V; Kaya, E; Keser, MF; Kose, A; Kuku, I; Memisoglu, F; Otan, E; Özer, AB; Özgül, M; Sarici, A, 2022) |
| "Patients who were diagnosed with sepsis/septic shock and treated with HA330 hemoperfusion adsorbent in addition to the standard treatment were included in this retrospective study conducted at Inonu University Turgut Ozal Medical Center between January 1, 2019 and January 1, 2021." | ( Aydogan, MS; Berber, I; Biçim, S; Erkurt, MA; Ince, V; Kaya, E; Keser, MF; Kose, A; Kuku, I; Memisoglu, F; Otan, E; Özer, AB; Özgül, M; Sarici, A, 2022) |
| "Severe sepsis or septic shock incidents, inadequate empirical antimicrobial therapy and corticosteroids use preceding infection onset caused significant increase of mortality rates in CRKP-BSI patients." | ( Chen, J; Cui, Y; Huang, X; Ma, H; Ma, S; Niu, R; Pan, P; Peng, W; Rao, M; Su, L; Yang, H; Zhang, P; Zhu, F, 2022) |
| "Critically ill patients with septic shock who received continuous veno-venous hemodiafiltration and HA 330 treatment were included in this prospective observational study." | ( Akin, AK; Baskol, G; Dogru, K; Gundogan, K; Onuk, S; Sari, A; Sungur, M, 2023) |
| "Persistent bacteremia, septic shock, recovery from neutropenia, prolonged or profound neutropenia, requirement of intensive care and dialysis, and initiation of appropriate empirical therapy were also studied." | ( Abraham, A; Balaji, V; Bhanuprasad, K; Chacko, B; George, B; George, MM; John, GM; Korula, A; Kulkarni, UP; Mathews, V; Premkumar, PS; Sathya Kumar, AM; Shankar, C; Subramani, K; Varghese, GM, 2023) |
| "Control patients with IAS and septic shock (n = 20) were treated using conventional protocols without EHP." | ( Berdnikov, G; Chaus, N; Chumachenko, A; Ignatenko, O; Kim, T; Krotenko, N; Kulabukhov, VM; Magomedov, M; Marysheva, A; Masolitin, S; Mendibaev, M; Nikitina, O; Ohinko, L; Pisarev, V; Popov, A; Rey, S, 2023) |
| "Coccidioidomycosis-related septic shock is a rare disease with poor outcomes; delays in diagnosis and treatment are common." | ( Ausman, C; Edmondson, J; Ewers, EC; Maves, RC; McCool, I; Perry, A; Walsh, JC; Wisniewski, P, 2023) |
| "Compared with control group for septic shock, dexmedetomidine treatment was able to substantially decrease Sequential Organ Failure Assessment score (mean difference [MD] = -0." | ( He, C; Huang, X, 2023) |
| "Among patients with septic shock with tachycardia and treated with norepinephrine for more than 24 hours, an infusion of landiolol did not reduce organ failure measured by the SOFA score over 14 days from randomization." | ( Bion, J; Boota, N; Gates, S; Ghuman, B; Gordon, AC; Hill, M; Hossain, A; Innes, R; Lall, R; Lord, J; MacCallum, NS; McAuley, D; Mistry, D; Perkins, GD; Regan, SE; Singer, M; Skilton, E; Veenith, T; Welters, I; Whitehouse, T; Yeung, J; Young, D, 2023) |