ascorbic-acid has been researched along with methylurea* in 2 studies
2 other study(ies) available for ascorbic-acid and methylurea
| Article | Year |
|---|---|
Inhibitory effects of para-aminobenzoic acid on the formation and mutagenicity of N-nitroso compounds.
Naturally occurring para-aminobenzoic acid (PABA) inhibited the formation of N-methyl-N-nitrosourea (MNU) from a nitrosation mixture of N-methylurea and nitrite at pH 3. The suppressive effect of PABA on the formation of MNU is higher than that of ascorbic acid. The presence of the MNU was assayed by its mutagenicity in a higher plant, Arabidopsis thaliana. In addition, PABA markedly reduced the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine in A.thaliana, but had no or only a low inhibitory effect on the mutagenicity of preformed MNU and on the promutagen N-nitrosodimethylamine. Topics: 4-Aminobenzoic Acid; Aminobenzoates; Ascorbic Acid; Biotransformation; Dimethylnitrosamine; Methylnitronitrosoguanidine; Methylnitrosourea; Methylurea Compounds; Mutagenicity Tests; Mutation; Nitrites; Nitroso Compounds; Plants | 1988 |
[Prevention using ascorbic acid, hexamethylenetetramine and sodium metabisulfite of the blastomogenic effect caused by the combined administration into the stomach of mice of sodium nitrite with methylurea or with aminopyrine].
It was shown in experiments on 186 mice that formation of tumors of the lung and fore-stomach induced by injection of sodium nitrite in combination with aminopyrine or methylurea is inhibited following treatment with ascorbic acid, hexamethylenetetramine or sodium metabisulfite. Topics: Aminopyrine; Animals; Ascorbic Acid; Cocarcinogenesis; Female; Lung Neoplasms; Male; Methenamine; Methylurea Compounds; Mice; Mice, Inbred Strains; Nitrites; Sodium Nitrite; Stomach Neoplasms; Sulfites | 1988 |