Salivary Gland Calculi

Calculi occurring in a salivary gland. Most salivary gland calculi occur in the submandibular gland, but can also occur in the parotid gland and in the sublingual and minor salivary glands.

Synonym
Salivary Gland Calculi
Salivary Gland Stones
Sialolithiasis
Sialoliths

Excerpt	Reference
"If sialolithiasis is not treated early obstructive sialadenitis will develop and its repeated relapses may lead to fibrosis and degeneration of glandular parenchyma."	( Antoniadis, D; Eleftheriadis, I; Konstantinidis, A; Papanayotou, P, 1990)
"Sialolithiasis is a common disease of salivary glands."	( Costa-Bauzá, A; Grases, F; Santiago, C; Simonet, BM, 2003)
"Sialoliths are common in the submandibular gland and its duct system."	( Akkocaoğlu, M; Er, N; Kasaboğlu, O; Tümer, C, 2004)
"Sialolithiasis is common in salivary glands, especially in the submandibular and parotid ducts."	( Delahougue, K; Faure, F; Gustin, MP; Hartmann, DJ; Machon, C; Sabot, JF, 2012)
"Sialoliths are common in the submandibular gland and its duct system, although their exact cause of formation is still a matter of debate."	( Agarwal, K; Agarwal, M; Bhoomareddy Kantharaj, YD; Rakesh, N, 2014)
"Sialolithiasis is a common disease of the salivary gland."	( Chunyuan, L; Linlin, C; Qiang, Z; Weibing, T; Yu, L, 2014)
"Since sialoliths are comprised mainly of calcium phosphate salts, we hypothesise that drinking water calcium levels and other elements in drinking water could play a role in sialolithiasis."	( Bardow, A; Homøe, P; Lundager Madsen, HE; Schrøder, S; Vataire, AL; Wagner, N, 2015)
"Sialolithiasis is the most common disease of the salivary glands."	( Abe, A; Hayashi, H; Kurita, K; Minagawa, M, 2019)
"Sialolithiasis is the primary etiology for parotid and submandibular swelling, potentially resulting in discomfort, bacterial infections, and hospitalization."	( Chole, RA; Kao, WK; Ogden, MA, 2020)
"Salivary stones (sialoliths) are calcified structures located in the ductal system of the major salivary glands."	( Apperloo, RC; Bikker, FJ; Brand, HS; de Visscher, JGAM; Kraaij, S; Nazmi, K, 2023)
"Salivary stones (sialoliths) are calcified structures located in the ductal system of the major salivary glands."	( Apperloo, RC; Bikker, FJ; Brand, HS; de Visscher, JGAM; Kraaij, S; Nazmi, K, 2023)
"Salivary stones (sialoliths) are calcified structures located in the ductal system of the major salivary glands."	( Apperloo, RC; Bikker, FJ; Brand, HS; de Visscher, JGAM; Kraaij, S; Nazmi, K, 2023)

Excerpt	Reference
"Symptomatic sialolithiasis has a prevalence of 0."	( Alexiou, C; Grüneboom, A; Herrmann, I; Herrmann, M; Iro, H; Knopf, J; Koch, M; Leppkes, M; Mahajan, A; Muñoz, LE; Schapher, M; Schauer, C; Schett, G; Scholz, M; Singh, J; Weidner, D; Wirtz, S, 2020)

Excerpt	Reference
"Twelve patients suffering from a sialolithiasis of the submandibular gland were treated."	( Gundlach, P; Hirst, L; Hopf, J; Leege, N; Müller, G; Scherer, H; Scholz, C, 1990)
"However, the treatment of parotid sialolithiasis remains inadequate."	( Nguyen Hong, L, 2021)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	8 (9.09)	23.3326
1990's	21 (23.86)	12.5806
2000's	16 (18.18)	18.1394
2010's	27 (30.68)	28.8240
2020's	16 (18.18)	9.53

Drug	Relationship Strength	Studies	Trials
citric acid, anhydrous	low	1	0
chlorine	low	3	0
formaldehyde	low	1	0
phytic acid	low	1	0
nitrous oxide	low	1	0
uric acid	low	2	0
alfuzosin	low	1	0
guaifenesin	low	3	0
hydrochlorothiazide	low	1	0
lidocaine	low	2	0
iohexol	low	2	0
iopromide	low	1	0
isoflurane	low	1	0
isoproterenol	low	1	0
mitoxantrone	low	1	0
procaine	low	1	0
mitomycin	low	1	0
prednisone	low	1	0
penicillin g	low	1	0
tyrosine	low	1	0
methylene blue	low	1	0
diatrizoate meglumine	low	1	0
quinazolines	low	1	0
limestone	low	3	0
malondialdehyde	low	1	0
gentian violet	low	1	0
durapatite	low	5	0
sulfur hexafluoride	medium	1	1
dithiothreitol	low	1	0
vidarabine	low	1	0
thulium	low	1	0
erbium	medium	1	1
gold	low	1	0
holmium	medium	6	1
yttrium	medium	2	1
magnesium phosphate (2:3)	low	1	0
calcium phosphate, dibasic, anhydrous	low	3	0
calcium phosphate, monobasic, anhydrous	low	3	0
tricalcium phosphate	low	11	0
calcium oxalate	low	2	0
methyldopa	low	1	0
atomoxetine hydrochloride	low	1	0
cephalosporin c	low	1	0
calcium phosphate, dibasic, dihydrate	low	1	0
octacalcium phosphate	low	1	0
atazanavir sulfate	low	1	0
calcium pyrophosphate	low	3	0
ritonavir	low	1	0
inositol 3-phosphate	low	6	0
D-fructopyranose	low	1	0
sodium dodecyl sulfate	low	1	0
phenylephrine hydrochloride	low	3	0
topiramate	low	1	0
aluminum	medium	2	1
sulfur	low	2	0
phosphorus	low	4	0
struvite	low	2	0
acid phosphatase	low	1	0
technetium tc 99m sestamibi	low	1	0
sodium pertechnetate tc 99m	low	9	0
ascorbic acid	low	1	0
whitlockite	low	4	0
lactoferrin	low	3	0
muramidase	low	3	0

Protein Targets (668)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, HADH2 protein	4	0	0	4
Chain B, HADH2 protein	4	0	0	4
Chain A, 2-oxoglutarate Oxygenase	6	0	0	6
thioredoxin reductase	8	0	0	8
USP1 protein, partial	6	0	0	6
aldehyde dehydrogenase 1 family, member A1	7	0	0	7
EWS/FLI fusion protein	7	0	0	7
glucocerebrosidase	2	0	0	2
alpha-galactosidase	3	0	0	3
euchromatic histone-lysine N-methyltransferase 2	13	0	0	13
lysosomal alpha-glucosidase preproprotein	3	0	0	3
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	4	0	0	4
flap endonuclease 1	6	0	0	6
Alpha-1A adrenergic receptor	0	1	0	1
Solute carrier family 22 member 1	0	3	0	4
Neuronal acetylcholine receptor subunit alpha-4	2	0	0	2
Neuronal acetylcholine receptor subunit beta-2	2	0	0	2
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	3	0	3
Alpha-2C adrenergic receptor	0	3	0	3
Acetylcholinesterase	0	2	0	2
Alpha-2A adrenergic receptor	0	3	0	3
Alpha-1D adrenergic receptor	0	5	0	5
Alpha-1D adrenergic receptor	0	4	1	5
Alpha-1A adrenergic receptor	0	2	1	3
Alpha-1B adrenergic receptor	0	2	1	3
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Sodium channel protein type 5 subunit alpha	0	2	0	2
Potassium voltage-gated channel subfamily D member 3	0	1	0	1
ATP-dependent phosphofructokinase	7	0	0	7
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	6	0	0	6
RAR-related orphan receptor gamma	10	0	0	10
GLI family zinc finger 3	15	0	0	15
AR protein	11	0	0	11
thioredoxin glutathione reductase	4	0	0	4
cytochrome P450 family 3 subfamily A polypeptide 4	8	0	0	8
glucocorticoid receptor [Homo sapiens]	9	0	0	9
retinoic acid nuclear receptor alpha variant 1	11	0	0	11
estrogen-related nuclear receptor alpha	14	0	0	14
estrogen nuclear receptor alpha	15	0	0	15
vitamin D (1,25- dihydroxyvitamin D3) receptor	7	0	0	7
IDH1	6	0	0	6
chromobox protein homolog 1	9	0	0	9
nuclear factor erythroid 2-related factor 2 isoform 2	5	0	0	5
thyroid hormone receptor beta isoform 2	8	0	0	8
nuclear factor erythroid 2-related factor 2 isoform 1	11	0	0	11
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
geminin	16	0	0	16
lethal factor (plasmid)	4	0	0	4
lamin isoform A-delta10	6	0	0	6
Polyphenol oxidase 2	0	1	0	2
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	2
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	2	1	3
Spike glycoprotein	10	0	0	10
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
glp-1 receptor, partial	5	0	0	5
TDP1 protein	13	0	0	13
estrogen receptor 2 (ER beta)	7	0	0	7
nuclear receptor subfamily 1, group I, member 3	11	0	0	11
progesterone receptor	8	0	0	8
cytochrome P450 2D6	6	0	0	6
peroxisome proliferator-activated receptor delta	7	0	0	7
thyroid stimulating hormone receptor	6	0	0	6
v-jun sarcoma virus 17 oncogene homolog (avian)	7	0	0	7
ATP-binding cassette sub-family C member 3	0	7	0	7
Multidrug resistance-associated protein 4	0	7	0	7
Bile salt export pump	0	12	0	12
Cellular tumor antigen p53	10	0	0	10
Sodium-dependent noradrenaline transporter	0	3	1	4
Canalicular multispecific organic anion transporter 1	0	7	0	7
Histone H2A.x	6	0	0	6
Voltage-dependent calcium channel gamma-2 subunit	6	0	0	6
Glutamate receptor 2	6	0	0	6
Carbonic anhydrase 1	0	5	0	7
Carbonic anhydrase 2	0	6	1	9
Carbonic anhydrase 4	0	3	0	5
Carbonic anhydrase	0	3	0	4
Carbonic anhydrase 15	0	2	0	3
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	5	0	0	5
farnesoid X nuclear receptor	9	0	0	9
peroxisome proliferator activated receptor gamma	8	0	0	8
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
perilipin-5	0	1	0	1
thyroid hormone receptor beta isoform a	5	0	0	5
perilipin-1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Beta-lactamase	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
3-dehydroquinate dehydratase	0	0	1	1
ATP-citrate synthase	0	0	0	1
Ribonuclease T	0	0	0	1
Cell death-related nuclease 4	0	0	0	1
3-dehydroquinate dehydratase	0	0	1	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Hsf1 protein	0	0	2	2
survival motor neuron protein isoform d	6	0	0	6
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	7	0	0	7
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	5	0	0	5
Chain A, Putative fructose-1,6-bisphosphate aldolase	4	0	0	4
Chain A, ATP-DEPENDENT DNA HELICASE Q1	5	0	0	5
Chain A, Ferritin light chain	4	0	0	4
Chain A, Cruzipain	3	0	0	3
Luciferase	5	0	0	5
beta-amyloid peptide, A beta {N-terminal} [human, cerebrospinal fluid, conditioned medium of mixed-brain cell cultures, Peptide Partial, 33 aa]	1	0	0	1
pregnane X receptor	2	0	0	2
phosphopantetheinyl transferase	5	0	0	5
hypoxia-inducible factor 1 alpha subunit	5	0	0	5
SMAD family member 2	6	0	0	6
SMAD family member 3	6	0	0	6
Microtubule-associated protein tau	7	0	0	8
caspase 7, apoptosis-related cysteine protease	3	0	0	3
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	4	0	0	4
thyroid stimulating hormone receptor	3	0	0	3
alpha synuclein, partial	1	0	0	1
hypothetical protein, conserved	4	0	0	4
retinoid X nuclear receptor alpha	8	0	0	8
pregnane X nuclear receptor	8	0	0	8
G	5	0	0	5
67.9K protein	4	0	0	4
luciferase	2	0	0	2
caspase-3	3	0	0	3
aryl hydrocarbon receptor	5	0	0	5
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	6	0	0	6
activating transcription factor 6	5	0	0	5
thyrotropin-releasing hormone receptor	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
Caspase-7	1	0	0	1
Bloom syndrome protein isoform 1	5	0	0	5
cellular tumor antigen p53 isoform a	2	0	0	2
tumor necrosis factor	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
vitamin D3 receptor isoform VDRA	8	0	0	8
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
caspase-3	1	0	0	1
histone deacetylase 9 isoform 3	2	0	0	2
heat shock protein beta-1	3	0	0	3
huntingtin isoform 2	4	0	0	4
mitogen-activated protein kinase 1	6	0	0	6
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
nuclear receptor ROR-gamma isoform 1	5	0	0	5
DNA polymerase kappa isoform 1	4	0	0	4
peripheral myelin protein 22	4	0	0	4
cytochrome P450 3A4 isoform 1	5	0	0	5
Gamma-aminobutyric acid receptor subunit pi	5	0	0	5
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
Epidermal growth factor receptor	0	4	0	4
Interferon beta	6	0	0	6
HLA class I histocompatibility antigen, B alpha chain	5	0	0	5
Integrin beta-3	2	0	0	2
Tyrosine-protein kinase Fyn	0	3	0	3
Muscarinic acetylcholine receptor M2	0	4	0	4
Muscarinic acetylcholine receptor M4	0	4	0	4
Integrin alpha-IIb	2	0	0	2
Cytochrome P450 3A4	0	5	0	6
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
60 kDa chaperonin	0	1	0	1
Adenosine receptor A3	0	2	0	2
Cytochrome P450 2D6	0	3	0	3
60 kDa heat shock protein, mitochondrial	0	1	0	1
Muscarinic acetylcholine receptor M1	0	4	0	4
D(2) dopamine receptor	0	3	0	3
Androgen receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	5	0	0	5
Alpha-1B adrenergic receptor	0	6	0	6
Gamma-aminobutyric acid receptor subunit delta	5	0	0	5
Gamma-aminobutyric acid receptor subunit gamma-2	5	0	0	5
Alpha-2C adrenergic receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-3	5	0	0	5
Muscarinic acetylcholine receptor M3	0	2	0	2
Substance-K receptor	0	4	0	4
D(1A) dopamine receptor	0	3	0	3
Glutamate receptor ionotropic, kainate 1	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-2	5	0	0	5
Histamine H2 receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	5	0	0	5
Gamma-aminobutyric acid receptor subunit gamma-3	5	0	0	5
Adenosine receptor A2a	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	5	0	0	5
Mu-type opioid receptor	0	4	0	4
D(3) dopamine receptor	0	3	0	3
Kappa-type opioid receptor	0	4	0	4
Glutamate receptor ionotropic, kainate 2	1	0	0	1
Glutamate receptor ionotropic, kainate 3	1	0	0	1
Alpha-1A adrenergic receptor	0	6	0	6
Histamine H2 receptor	4	0	1	5
Nuclear receptor ROR-gamma	2	0	0	2
10 kDa heat shock protein, mitochondrial	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	5	0	0	5
Gamma-aminobutyric acid receptor subunit beta-3	5	0	0	5
Gamma-aminobutyric acid receptor subunit beta-2	5	0	0	5
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Fatty-acid amide hydrolase 1	1	0	0	1
Inositol monophosphatase 1	3	0	0	3
Glutamate receptor ionotropic, kainate 4	1	0	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Leukotriene B4 receptor 1	1	0	0	1
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
Glutamate receptor ionotropic, kainate 5	1	0	0	1
10 kDa chaperonin	0	1	0	1
GABA theta subunit	5	0	0	5
Inositol hexakisphosphate kinase 1	5	0	0	5
ATPase family AAA domain-containing protein 5	3	0	0	3
Ataxin-2	5	0	0	5
Gamma-aminobutyric acid receptor subunit epsilon	5	0	0	5
Leukotriene B4 receptor 2	1	0	0	1
cytochrome P450 2C9, partial	5	0	0	5
Rap guanine nucleotide exchange factor 3	2	0	0	2
Carbonic anhydrase	0	2	0	2
ATAD5 protein, partial	4	0	0	4
Carbonic anhydrase	0	2	0	2
arylsulfatase A	3	0	0	3
peripheral myelin protein 22 isoform 1	2	0	0	2
cytochrome P450 2C9 precursor	1	0	0	1
Solute carrier family 22 member 6	0	2	0	2
Carbonic anhydrase 12	0	2	0	4
Albumin	0	1	0	3
Carbonic anhydrase 3	0	2	0	3
Cytochrome P450 2C9	0	4	0	4
Carbonic anhydrase 6	0	2	0	4
Delta-type opioid receptor	0	2	0	2
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Carbonic anhydrase 5A, mitochondrial	0	2	1	5
Carbonic anhydrase 7	0	2	0	4
Cytochrome P450 2J2	0	2	0	2
Guanine nucleotide-binding protein G	4	0	0	4
Mu-type opioid receptor	0	2	0	2
Carbonic anhydrase 9	0	2	0	4
Carbonic anhydrase, alpha family	0	2	0	2
Carbonic anhydrase	0	2	0	2
Delta carbonic anhydrase	0	2	0	2
Carbonic anhydrase 13	0	2	0	3
Carbonic anhydrase 14	0	2	0	4
Carbonic anhydrase 5B, mitochondrial	0	2	0	4
importin subunit beta-1 isoform 1	3	0	0	3
snurportin-1	3	0	0	3
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
GLS protein	5	0	0	5
regulator of G-protein signaling 4	4	0	0	4
NPYLR7B	0	0	1	1
Beta-1 adrenergic receptor	0	0	1	2
beta-2 adrenergic receptor	2	0	0	2
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	3	0	0	3
Bile salt export pump	0	2	0	2
Beta-2 adrenergic receptor	0	2	2	5
Beta-1 adrenergic receptor	0	2	1	3
Beta-2 adrenergic receptor	0	2	1	3
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
Beta-3 adrenergic receptor	0	1	1	2
Beta-1 adrenergic receptor	0	2	1	4
Beta-2 adrenergic receptor	0	0	1	1
D(4) dopamine receptor	0	1	0	1
Beta-adrenergic receptor kinase 1	0	0	1	1
Beta-3 adrenergic receptor	0	0	1	1
Beta-3 adrenergic receptor	0	1	1	2
Vasopressin V1a receptor	0	0	1	1
Beta-1 adrenergic receptor	0	1	1	2
Glutamate receptor ionotropic, NMDA 1	0	0	1	2
D(1A) dopamine receptor	2	0	0	2
Beta-2 adrenergic receptor	0	1	0	1
Taste receptor type 2 member 38	0	0	1	1
Taste receptor type 2 member 39	0	0	1	1
Taste receptor type 2 member 40	0	0	1	1
Taste receptor type 2 member 41	0	0	1	1
Taste receptor type 2 member 43	0	0	1	1
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 45	0	0	1	1
Taste receptor type 2 member 46	0	0	1	1
Taste receptor type 2 member 30	0	0	1	1
Taste receptor type 2 member 19	0	0	1	1
Taste receptor type 2 member 20	0	0	1	1
Taste receptor type 2 member 50	0	0	1	1
Taste receptor type 2 member 60	0	0	1	1
Oxytocin receptor	0	0	1	1
Glutamate receptor ionotropic, NMDA 2A	0	0	1	2
Glutamate receptor ionotropic, NMDA 2B	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	0	1	2
Beta-2 adrenergic receptor	0	1	1	2
Glutamate receptor ionotropic, NMDA 2D	0	0	1	2
Taste receptor type 2 member 42	0	0	1	1
Beta-2 adrenergic receptor	0	0	2	2
Glutamate receptor ionotropic, NMDA 3B	0	0	1	2
Taste receptor type 2 member 16	0	0	1	1
Taste receptor type 2 member 14	0	0	1	2
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 10	0	0	1	1
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 8	0	0	1	1
Taste receptor type 2 member 7	0	0	1	1
Taste receptor type 2 member 5	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Taste receptor type 2 member 3	0	0	1	1
Taste receptor type 2 member 1	0	0	1	1
Glutamate receptor ionotropic, NMDA 3A	0	0	1	2
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	3	0	0	3
Chain A, Beta-lactamase	3	0	0	3
muscarinic acetylcholine receptor M1	3	0	0	3
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Multidrug and toxin extrusion protein 1	0	3	0	3
Sodium channel protein type 3 subunit alpha	0	1	0	1
endonuclease IV	1	0	0	1
15-lipoxygenase, partial	2	0	0	2
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	2
Smad3	3	0	0	3
apical membrane antigen 1, AMA1	3	0	0	3
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
pyruvate kinase	2	0	0	2
estrogen receptor beta isoform 1	0	1	0	1
DNA polymerase beta	2	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
DNA polymerase eta isoform 1	3	0	0	3
DNA polymerase iota isoform a (long)	5	0	0	5
M-phase phosphoprotein 8	2	0	0	2
muscleblind-like protein 1 isoform 1	3	0	0	3
histone acetyltransferase KAT2A isoform 1	6	0	0	6
Cystathionine gamma-lyase	0	1	0	1
Solute carrier family 15 member 1	0	2	0	2
phosphoglycerate kinase	3	0	0	3
Chain E, Fibrin beta chain	0	1	0	1
T cell receptor, partial	1	0	0	1
luteinizing hormone receptor	1	0	0	1
integrase, partial	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
lens epithelium-derived growth factor p75	0	1	0	1
Fumarate hydratase	4	0	0	4
PPM1D protein	2	0	0	2
TSHR protein	1	0	0	1
Apoptotic peptidase activating factor 1	0	1	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
polyprotein	4	0	0	4
serine-protein kinase ATM isoform a	1	0	0	1
neutrophil cytosol factor 1	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
caspase-9 isoform alpha precursor	0	1	0	1
pyruvate kinase PKM isoform a	2	0	0	2
caspase-3 isoform a preproprotein	0	1	0	1
protein AF-9 isoform a	0	0	0	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
Vpr	3	0	0	3
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
POsterior Segregation	0	0	1	1
DNA repair protein RAD52 homolog isoform a	0	0	0	2
neuropeptide S receptor isoform A	2	0	0	2
Glutathione reductase	0	1	0	1
Glutathione reductase, mitochondrial	0	1	0	2
Glycoprotein hormones alpha chain	2	0	0	2
Amyloid-beta precursor protein	1	1	0	2
Dihydrolipoyl dehydrogenase, mitochondrial	0	1	0	2
Microtubule-associated protein tau	0	1	1	2
Amine oxidase [flavin-containing] A	0	1	0	1
Cruzipain	0	1	0	1
Alpha-synuclein	1	0	0	1
TAR DNA-binding protein 43	1	1	0	2
Thioredoxin reductase 1, cytoplasmic	0	1	0	2
Dihydrolipoyl dehydrogenase	0	1	0	2
Zinc finger protein mex-5	0	0	1	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Chain A, Probable serine/threonine-protein kinase pknB	0	1	0	1
dopamine D1 receptor	1	0	0	1
WRN	1	0	0	1
NFKB1 protein, partial	1	0	0	1
Thrombopoietin	1	0	0	1
DNA polymerase III, partial	1	0	0	1
nonstructural protein 1	0	1	0	1
LANA	0	0	0	1
Parkin	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
phospholipase A2, group III	0	1	0	1
cytochrome P450 2D6 isoform 1	2	0	0	2
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
interferon gamma precursor	0	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
histone-lysine N-methyltransferase NSD2 isoform 1	0	0	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
ras-related protein Rab-9A	1	0	0	1
tyrosine-protein kinase Yes	1	0	0	1
dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	0	1
rac GTPase-activating protein 1 isoform a	0	1	0	1
pyruvate kinase PKM isoform b	1	0	0	1
Solute carrier family 22 member 2	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
Solute carrier family 22 member 3	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
ATP-dependent translocase ABCB1	0	3	0	3
Proto-oncogene tyrosine-protein kinase ROS	0	1	0	1
Ornithine decarboxylase	1	0	0	1
DNA topoisomerase 2-alpha	0	1	0	2
Angiotensin-converting enzyme	0	2	0	2
DNA topoisomerase 2	0	0	0	1
Casein kinase II subunit alpha'	0	1	0	1
5-hydroxytryptamine receptor 2C	0	2	0	2
Multidrug resistance-associated protein 1	0	1	0	1
Casein kinase II subunit beta	0	1	0	1
Casein kinase II subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
DNA topoisomerase 2-beta	0	0	0	1
Tyrosine-protein kinase BTK	0	1	0	1
NEDD8-activating enzyme E1 regulatory subunit	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Integrase	0	1	0	1
Multidrug and toxin extrusion protein 2	0	2	0	2
Casein kinase II subunit alpha 3	0	1	0	1
NEDD8-activating enzyme E1 catalytic subunit	0	0	1	1
Single-stranded DNA cytosine deaminase	1	0	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	4	0	4
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	3	0	4
ClpP	1	0	0	1
Mcl-1	0	1	0	1
cytochrome P450 2C19 precursor	1	0	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	1
Bifunctional cytochrome P450/NADPH--P450 reductase	0	0	1	1
UDP-glucuronosyltransferase 2B7	0	1	0	1
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	1	0	1
Bombesin receptor subtype-3	0	0	1	1
Cytochrome P450 2C19	0	3	0	4
UDP-glucuronosyltransferase 2B10	0	1	0	1
Fatty acid synthase	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 2	0	0	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	1
WD repeat-containing protein 5	0	1	0	1
Glutathione S-transferase omega-1	0	1	0	1
Histone-lysine N-methyltransferase 2A	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Cytosolic endo-beta-N-acetylglucosaminidase	0	1	0	1
Muscarinic acetylcholine receptor	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Metallo-beta-lactamase VIM-11	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
streptokinase A precursor	0	0	1	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	1	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase 1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase OXA-10	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Kappa-type opioid receptor	0	0	0	1
Beta-lactamase TEM	0	1	0	2
Beta-lactamase	0	0	0	1
B2 metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Metallo-beta-lactamase VIM-13	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase Toho-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-b-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	2	0	2
Beta-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	1	0	2
Beta-lactamase VIM-1	0	0	0	1
GALC protein	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Chain D, PROTEIN (PHOSPHOGLYCERATE MUTASE 1)	0	1	0	1
Chain A, PROTEIN (PHOSPHOGLYCERATE MUTASE 1)	0	1	0	1
Chain A, Beta-arrestin 1	0	0	1	1
Glucocorticoid receptor	0	2	1	3
Glycine receptor subunit alpha-1	0	2	0	2
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Chain A, dATP pyrophosphohydrolase	0	1	0	1
Chain A, Adenylate cyclase type 5	0	1	0	1
Chain B, Adenylate cyclase type 2	0	1	0	1
Chain A, HIV-1 PROTEASE	0	1	0	1
Chain B, HIV-1 PROTEASE	0	1	0	1
Chain A, POL polyprotein	0	1	0	1
Chain B, POL polyprotein	0	1	0	1
Chain A, POL polyprotein	0	1	0	1
Chain B, POL polyprotein	0	1	0	1
Chain A, Endothiapepsin	0	1	0	1
Chain A, Endothiapepsin	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Gag-Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Cytochrome P450 3A5	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Thromboxane-A synthase	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Vasopressin V1a receptor	0	2	0	2
Thromboxane-A synthase	0	0	0	1
Sodium/bile acid cotransporter	0	1	0	1
Protease	0	1	1	4
Plasmepsin V	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	2	0	2
Protease	0	2	1	3
interleukin 8	1	0	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Peroxisome proliferator-activated receptor alpha	1	0	0	1
Chain A, Carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	0	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	1	0	2
D(2) dopamine receptor	0	1	0	1
Carbonic anhydrase	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase 13	0	1	0	1
Carbonic anhydrase 4	0	2	0	2
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Plasma kallikrein	0	0	0	1
Adenosine receptor A1	0	0	0	1
Adenosine receptor A2a	0	0	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
SLC16A10 protein	0	0	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Tubulin--tyrosine ligase	0	1	0	1
Monocarboxylate transporter 10	0	0	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 22 member 6	0	0	0	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
Thymidine kinase, cytosolic	0	0	0	1
Dipeptidyl peptidase 4	0	1	0	1
Histamine H1 receptor	0	0	1	1
Adenosylhomocysteinase	0	1	0	1
Adenosine deaminase	0	0	0	1
RNA-directed RNA polymerase	0	1	1	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(4)

Research Excerpts

Overview

Context

Treatment

Research

Studies (88)

Protein Targets (668)

Salivary Gland Calculi

Synonyms(4)

Research Excerpts

Overview

Context

Treatment

Research

Studies (88)

Drugs Studied (80)

Protein Targets (668)