An EC 4.3.* (C-N lyase) inhibitor that interferes with the action of phenylalanine ammonia-lyase (EC 4.3.1.24).
ChEBI ID: 62871
| Member | Definition | Class |
|---|---|---|
| cinnamaldehyde | The E (trans) stereoisomer of cinnamaldehyde, the parent of the class of cinnamaldehydes. | (E)-cinnamaldehyde |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 57 (4.35) | 18.7374 |
| 1990's | 71 (5.42) | 18.2507 |
| 2000's | 222 (16.95) | 29.6817 |
| 2010's | 625 (47.71) | 24.3611 |
| 2020's | 335 (25.57) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 34 (2.54%) | 5.53% |
| Reviews | 46 (3.44%) | 6.00% |
| Case Studies | 27 (2.02%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 1,230 (92.00%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 67.9K protein | Vaccinia virus | Potency | 22.3872 | 1 | 1 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 49.9825 | 2 | 2 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 7.5506 | 1 | 2 |
| AR protein | Homo sapiens (human) | Potency | 32.4312 | 5 | 5 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 64.8601 | 2 | 2 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 42.1234 | 1 | 2 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 28.6206 | 1 | 2 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 35.9065 | 6 | 9 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 29.7882 | 3 | 3 |
| geminin | Homo sapiens (human) | Potency | 0.1458 | 1 | 1 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 10.8005 | 2 | 3 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 30.6379 | 1 | 1 |
| IDH1 | Homo sapiens (human) | Potency | 29.0929 | 1 | 1 |
| interleukin 8 | Homo sapiens (human) | Potency | 70.9011 | 1 | 2 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 0.6310 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 44.7853 | 1 | 1 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 62.9335 | 3 | 5 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 37.5780 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 12.5893 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 45.7029 | 3 | 4 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 112.2020 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 18.1056 | 1 | 1 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 43.6465 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 61.8710 | 1 | 3 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 25.8212 | 2 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 34.5925 | 3 | 4 |
| shiga toxin 1 B subunit | Escherichia coli O157:H7 | Potency | 10.0238 | 2 | 2 |
| shiga toxin 1 variant A subunit | Escherichia coli O157:H7 | Potency | 10.0238 | 2 | 2 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 30.6379 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Cell division protein FtsZ | Escherichia coli K-12 | IC50 | 6.3350 | 2 | 2 |
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 520.0000 | 1 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | IC50 | 35.0000 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | IC50 | 245.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily A member 1 | Homo sapiens (human) | EC50 | 18.8823 | 4 | 5 |
| Transient receptor potential cation channel subfamily A member 1 | Mus musculus (house mouse) | EC50 | 61.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Cell division protein FtsZ | Escherichia coli K-12 | INH | 6.3100 | 2 | 2 |
| Cell division protein FtsZ | Escherichia coli K-12 | Ka | 1.0000 | 1 | 1 |
| Transient receptor potential cation channel subfamily A member 1 | Homo sapiens (human) | Activity | 10.0000 | 1 | 1 |