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primary alpha-hydroxy ketone
An alpha-hydroxy ketone in which the carbonyl group and the hydroxy group are linked by a -CH2 (methylene) group.
ChEBI ID: 139590
Members (37)
| Member | Definition | Role |
|---|---|---|
| 11-dehydrocorticosterone | An 11-oxo steroid that is corticosterone in which the hydroxy substituent at the 11beta position has been oxidised to give the corresponding ketone. | 11-dehydrocorticosterone |
| 18-hydroxycorticosterone | A 18-hydroxy steroid that is corticosterone substituted by a hydroxy group at position 18. | 18-hydroxycorticosterone |
| 21-hydroxypregnenolone | A hydroxypregnenolone that is pregnenolone which has been substituted by a hydroxy group at position 21. | 21-hydroxypregnenolone |
| 4'-deoxy-4'-iododoxorubicin | 4'-deoxy-4'-iododoxorubicin | |
| 5-dihydrocortisone | A 4,5-dihydrocortisone that has beta- configuration at position 5. | 17,21-dihydroxy-5beta-pregnane-3,11,20-trione |
| 6 beta-hydroxycortisol | A C21-steroid that is cortisol bearing an additional hydroxy substituent at the 6beta-position. In humans, it is produced as a metabolite of cortisol by cytochrome p450-3A4 (CYP3A4, an important enzyme involved in the metabolism of a variety of exogenous and endogenous compounds) and can be used to detect moderate and potent CYP3A4 inhibition in vivo. | 6beta-hydroxycortisol |
| acetol | A propanone that is acetone in which one of the methyl hydrogens is replaced by a hydroxy group. | hydroxyacetone |
| aldosterone | A pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney. | aldosterone |
| beclomethasone | A 17alpha-hydroxy steroid that is prednisolone in which the hydrogens at the 9alpha and 16beta positions are substituted by a chlorine and a methyl group, respectively. | beclomethasone |
| betamethasone | betamethasone | |
| betamethasone valerate | A steroid ester that is betamethasone in which the hydroxy group at the 17alpha position has been converted to the corresponding pentanoate ester. | betamethasone valerate |
| corticosterone | A 21-hydroxy steroid that consists of pregn-4-ene substituted by hydroxy groups at positions 11 and 21 and oxo groups at positions 3 and 20. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands. | corticosterone |
| cortisone | A C21-steroid that is pregn-4-ene substituted by hydroxy groups at positions 17 and 21 and oxo group at positions 3, 11 and 20. | cortisone |
| cortodoxone | A deoxycortisol that is cortisol in which the hydroxy group at position 11 has been replaced by a hydrogen. | 11-deoxycortisol |
| desonide | Triamcinolone acetonide with hydrogen instead of the fluorine substituent at position 9. A corticosteroid anti-inflammatory, it is used topically as a cream, ointment or lotion for the treatment of various skin disorders. | desonide |
| desoximetasone | Dexamethasone in which the hydroxy group at the 17alpha position is substituted by hydrogen. A synthetic corticosteroid with glucocorticoid activity, it is used as an anti-inflammatory and anti-pruritic in the treatment of various skin disorders, including skin allergies and psoriasis. | desoximetasone |
| desoxycorticosterone | A mineralocorticoid that is progesterone substituted at position 21 by a hydroxy group. | 11-deoxycorticosterone |
| diflorasone | The 16beta-analogue of flumethasone. It is used as the 17,21-diacetate as a topical anti-inflammatory and antipruritic in the treatment of various skin disorders. | diflorasone |
| dihydroxyacetone | A ketotriose consisting of acetone bearing hydroxy substituents at positions 1 and 3. The simplest member of the class of ketoses and the parent of the class of glycerones. | dihydroxyacetone |
| dihydroxyacetone phosphate | A member of the class of glycerone phosphates that consists of glycerone bearing a single phospho substituent. | dihydroxyacetone phosphate |
| epirubicin | An anthracycline that is the 4'-epi-isomer of doxorubicin. | 4'-epidoxorubicin |
| erythrulose | erythrulose | |
| flumethasone | flumethasone | |
| flunisolide | flunisolide | |
| fluocinolone acetonide | A fluorinated steroid that is flunisolide in which the hydrogen at position 9 is replaced by fluorine. A corticosteroid with glucocorticoid activity, it is used (both as the anhydrous form and as the dihydrate) in creams, gels and ointments for the treatment of various skin disorders. | fluocinolone acetonide |
| hydrocortisone valerate | cortisol 17-valerate | |
| hydrocortisone-17-butyrate | Cortisol esterified with butyric acid at the 17-hydroxy group. | cortisol 17-butyrate |
| hydroxydione | A 3-oxo-5beta-steroid formed from 11-deoxycorticosterone by reduction across the C4-C5 double bond. | 5beta-dihydrodeoxycorticosterone |
| hydroxypyruvic acid | A 2-oxo monocarboxylic acid that is pyruvic acid in which one of the methyl hydrogens is substituted by a hydroxy group. It is an intermediate involved in the glycine and serine metabolism. | 3-hydroxypyruvic acid |
| methoxy-morpholinyl-doxorubicin | nemorubicin | |
| methylprednisolone | The 6alpha-stereoisomer of 6-methylprednisolone. | 6alpha-methylprednisolone |
| prednisolone | A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone. | prednisolone |
| prednisone | A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid. | prednisone |
| pulmicort | A glucocorticoid steroid having a highly oxygenated pregna-1,4-diene structure. It is used mainly in the treatment of asthma and non-infectious rhinitis and for treatment and prevention of nasal polyposis. | budesonide |
| tetrahydrocortisol | tetrahydrocortisol | |
| triamcinolone | A C21-steroid hormone that is 1,4-pregnadiene-3,20-dione carrying four hydroxy substituents at positions 11beta, 16alpha, 17alpha and 21 as well as a fluoro substituent at position 9. Used in the form of its 16,17-acetonide to treat various skin infections. | triamcinolone |
| triamcinolone acetonide | A synthetic glucocorticoid that is the 16,17-acetonide of triamcinolone. Used to treat various skin infections. | triamcinolone acetonide |
Research
Studies (178,560)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 75,693 (42.39) | 18.7374 |
| 1990's | 27,684 (15.50) | 18.2507 |
| 2000's | 32,597 (18.26) | 29.6817 |
| 2010's | 33,177 (18.58) | 24.3611 |
| 2020's | 9,409 (5.27) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 20,213 (9.65%) | 5.53% |
| Reviews | 12,584 (6.01%) | 6.00% |
| Case Studies | 38,350 (18.32%) | 4.05% |
| Observational | 606 (0.29%) | 0.25% |
| Other | 137,601 (65.73%) | 84.16% |