Page last updated: 2024-08-05 10:47:17

primary alpha-hydroxy ketone

An alpha-hydroxy ketone in which the carbonyl group and the hydroxy group are linked by a -CH2 (methylene) group.

ChEBI ID: 139590

Members (37)

MemberDefinitionRole
11-dehydrocorticosteroneAn 11-oxo steroid that is corticosterone in which the hydroxy substituent at the 11beta position has been oxidised to give the corresponding ketone.11-dehydrocorticosterone
18-hydroxycorticosteroneA 18-hydroxy steroid that is corticosterone substituted by a hydroxy group at position 18.18-hydroxycorticosterone
21-hydroxypregnenoloneA hydroxypregnenolone that is pregnenolone which has been substituted by a hydroxy group at position 21.21-hydroxypregnenolone
4'-deoxy-4'-iododoxorubicin4'-deoxy-4'-iododoxorubicin
5-dihydrocortisoneA 4,5-dihydrocortisone that has beta- configuration at position 5.17,21-dihydroxy-5beta-pregnane-3,11,20-trione
6 beta-hydroxycortisolA C21-steroid that is cortisol bearing an additional hydroxy substituent at the 6beta-position. In humans, it is produced as a metabolite of cortisol by cytochrome p450-3A4 (CYP3A4, an important enzyme involved in the metabolism of a variety of exogenous and endogenous compounds) and can be used to detect moderate and potent CYP3A4 inhibition in vivo.6beta-hydroxycortisol
acetolA propanone that is acetone in which one of the methyl hydrogens is replaced by a hydroxy group.hydroxyacetone
aldosteroneA pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney.aldosterone
beclomethasoneA 17alpha-hydroxy steroid that is prednisolone in which the hydrogens at the 9alpha and 16beta positions are substituted by a chlorine and a methyl group, respectively.beclomethasone
betamethasonebetamethasone
betamethasone valerateA steroid ester that is betamethasone in which the hydroxy group at the 17alpha position has been converted to the corresponding pentanoate ester.betamethasone valerate
corticosteroneA 21-hydroxy steroid that consists of pregn-4-ene substituted by hydroxy groups at positions 11 and 21 and oxo groups at positions 3 and 20. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands.corticosterone
cortisoneA C21-steroid that is pregn-4-ene substituted by hydroxy groups at positions 17 and 21 and oxo group at positions 3, 11 and 20.cortisone
cortodoxoneA deoxycortisol that is cortisol in which the hydroxy group at position 11 has been replaced by a hydrogen.11-deoxycortisol
desonideTriamcinolone acetonide with hydrogen instead of the fluorine substituent at position 9. A corticosteroid anti-inflammatory, it is used topically as a cream, ointment or lotion for the treatment of various skin disorders.desonide
desoximetasoneDexamethasone in which the hydroxy group at the 17alpha position is substituted by hydrogen. A synthetic corticosteroid with glucocorticoid activity, it is used as an anti-inflammatory and anti-pruritic in the treatment of various skin disorders, including skin allergies and psoriasis.desoximetasone
desoxycorticosteroneA mineralocorticoid that is progesterone substituted at position 21 by a hydroxy group.11-deoxycorticosterone
diflorasoneThe 16beta-analogue of flumethasone. It is used as the 17,21-diacetate as a topical anti-inflammatory and antipruritic in the treatment of various skin disorders.diflorasone
dihydroxyacetoneA ketotriose consisting of acetone bearing hydroxy substituents at positions 1 and 3. The simplest member of the class of ketoses and the parent of the class of glycerones.dihydroxyacetone
dihydroxyacetone phosphateA member of the class of glycerone phosphates that consists of glycerone bearing a single phospho substituent.dihydroxyacetone phosphate
epirubicinAn anthracycline that is the 4'-epi-isomer of doxorubicin.4'-epidoxorubicin
erythruloseerythrulose
flumethasoneflumethasone
flunisolideflunisolide
fluocinolone acetonideA fluorinated steroid that is flunisolide in which the hydrogen at position 9 is replaced by fluorine. A corticosteroid with glucocorticoid activity, it is used (both as the anhydrous form and as the dihydrate) in creams, gels and ointments for the treatment of various skin disorders.fluocinolone acetonide
hydrocortisone valeratecortisol 17-valerate
hydrocortisone-17-butyrateCortisol esterified with butyric acid at the 17-hydroxy group.cortisol 17-butyrate
hydroxydioneA 3-oxo-5beta-steroid formed from 11-deoxycorticosterone by reduction across the C4-C5 double bond.5beta-dihydrodeoxycorticosterone
hydroxypyruvic acidA 2-oxo monocarboxylic acid that is pyruvic acid in which one of the methyl hydrogens is substituted by a hydroxy group. It is an intermediate involved in the glycine and serine metabolism.3-hydroxypyruvic acid
methoxy-morpholinyl-doxorubicinnemorubicin
methylprednisoloneThe 6alpha-stereoisomer of 6-methylprednisolone.6alpha-methylprednisolone
prednisoloneA glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.prednisolone
prednisoneA synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid.prednisone
pulmicortA glucocorticoid steroid having a highly oxygenated pregna-1,4-diene structure. It is used mainly in the treatment of asthma and non-infectious rhinitis and for treatment and prevention of nasal polyposis.budesonide
tetrahydrocortisoltetrahydrocortisol
triamcinoloneA C21-steroid hormone that is 1,4-pregnadiene-3,20-dione carrying four hydroxy substituents at positions 11beta, 16alpha, 17alpha and 21 as well as a fluoro substituent at position 9. Used in the form of its 16,17-acetonide to treat various skin infections.triamcinolone
triamcinolone acetonideA synthetic glucocorticoid that is the 16,17-acetonide of triamcinolone. Used to treat various skin infections.triamcinolone acetonide

Research

Studies (178,560)

TimeframeStudies, Drugs in This Class (%)All Drugs %
pre-199075,693 (42.39)18.7374
1990's27,684 (15.50)18.2507
2000's32,597 (18.26)29.6817
2010's33,177 (18.58)24.3611
2020's9,409 (5.27)2.80

Study Types

Publication TypeStudies, Drugs in This Class (%)All Drugs (%)
Trials20,213 (9.65%)5.53%
Reviews12,584 (6.01%)6.00%
Case Studies38,350 (18.32%)4.05%
Observational606 (0.29%)0.25%
Other137,601 (65.73%)84.16%