Compounds > (5z)-4-bromo-5-(bromomethylene)-3-butyl-2(5h)-furanone
Page last updated: 2024-12-11

(5z)-4-bromo-5-(bromomethylene)-3-butyl-2(5h)-furanone

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Description

The chemical name you provided, **(5z)-4-bromo-5-(bromomethylene)-3-butyl-2(5h)-furanone**, describes a specific molecule with a complex structure. Let's break down its importance in research:

**Understanding the Structure:**

* **Furanone:** This molecule belongs to the furanone family, which are cyclic organic compounds containing a five-membered ring with one oxygen atom.
* **Substituents:** The name reveals several substituents attached to the furanone ring:
* **4-bromo:** A bromine atom is attached at the 4th carbon position.
* **5-(bromomethylene):** A bromomethylene group (CHBr) is attached at the 5th carbon position.
* **3-butyl:** A butyl group (C4H9) is attached at the 3rd carbon position.
* **(5z):** This indicates the stereochemistry (spatial arrangement) of the bromomethylene group. The z designation implies a *cis* configuration, meaning the bromine and the hydrogen atom attached to the same carbon are on the same side of the double bond.

**Why It's Important in Research:**

This molecule, likely synthesized in a laboratory, could be important for research for several reasons:

* **Biological Activity:** Furanones are known to exhibit various biological activities, including antibacterial, antifungal, and anti-inflammatory properties. This specific molecule might have unique properties due to its structure and substituents. Researchers could be investigating its potential as a pharmaceutical lead compound.
* **Synthetic Chemistry:** The molecule could be a valuable intermediate for synthesizing other complex compounds, especially those with potential biological or industrial applications. Its unique structure and functional groups make it a promising starting material for various organic reactions.
* **Material Science:** The molecule's structure might suggest potential applications in materials science. For example, furanones can be used in the synthesis of polymers, resins, and other materials with specific properties.

**To fully understand its importance, more information is needed:**

* **Research Context:** What specific research area is the molecule being investigated in? Is it related to drug discovery, material science, or another field?
* **Synthesis and Characterization:** How was the molecule synthesized, and what methods are being used to study its properties?
* **Experimental Results:** Are there any preliminary findings or data about the molecule's activity or properties?

**In conclusion, (5z)-4-bromo-5-(bromomethylene)-3-butyl-2(5h)-furanone is a synthetically complex molecule with potential applications in various research fields. Its importance depends on the specific research context and the findings obtained through investigations.**

4-bromo-5Z-(bromomethylene)-3-butylfuran-2-one: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID9839657
CHEMBL ID448241
SCHEMBL ID1049932
MeSH IDM0423733

Synonyms (9)

Synonym
(5z)-4-bromo-5-(bromomethylene)-3-butyl-furan-2-one
4-bromo-5z-(bromomethylene)-3-butylfuran-2-one
uvjagaxwvhgyrw-alcczggfsa-
inchi=1/c9h10br2o2/c1-2-3-4-6-8(11)7(5-10)13-9(6)12/h5h,2-4h2,1h3/b7-5-
CHEMBL448241
SCHEMBL1049932
UVJAGAXWVHGYRW-ALCCZGGFSA-N
(5z)-4-bromo-5-(bromomethylene)-3-butyl-2(5h)-furanone
(5z)-4-bromo-5-(bromomethylidene)-3-butylfuran-2-one
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (84)

Assay IDTitleYearJournalArticle
AID580501Antimicrobial activity against Staphylococcus epidermidis 047 by macrodilution method2009Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
Furanone at subinhibitory concentrations enhances staphylococcal biofilm formation by luxS repression.
AID378086Cytotoxicity against human A431 cells2006Journal of natural products, Aug, Volume: 69, Issue:8
Biological activities and 3D QSAR studies of a series of Delisea pulchra (cf. fimbriata) derived natural products.
AID1062386Inhibition of quorum sensing system in Pseudomonas aeruginosa PAO1 MH602 harboring lasB promoter fused with GFP-ASV assessed as reduction in GFP-ASV reporter protein expression measured every 30 mins2013Journal of medicinal chemistry, Dec-12, Volume: 56, Issue:23
Design, synthesis, and evaluation of fimbrolide-nitric oxide donor hybrids as antimicrobial agents.
AID469253Inhibition of Escherichia coli LuxS using variable levels of S-ribosyl-homocysteine substrate at pH 7 after 10 mins by fluorimetric assay2009Bioorganic & medicinal chemistry letters, Nov-01, Volume: 19, Issue:21
A naturally occurring brominated furanone covalently modifies and inactivates LuxS.
AID580502Antimicrobial activity against ica gene-deficient Staphylococcus epidermidis 047 by macrodilution method2009Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
Furanone at subinhibitory concentrations enhances staphylococcal biofilm formation by luxS repression.
AID378099Antimicrobial activity against Bacillus subtilis at 5 ug2006Journal of natural products, Aug, Volume: 69, Issue:8
Biological activities and 3D QSAR studies of a series of Delisea pulchra (cf. fimbriata) derived natural products.
AID378080Cytotoxicity against human MEL-2 cells2006Journal of natural products, Aug, Volume: 69, Issue:8
Biological activities and 3D QSAR studies of a series of Delisea pulchra (cf. fimbriata) derived natural products.
AID580527Cytotoxicity against mouse L929 cells after 24 hrs at 28.4 +/- 8.4 uM by LDH release assay2009Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
Furanone at subinhibitory concentrations enhances staphylococcal biofilm formation by luxS repression.
AID513996Antimicrobial activity against Salmonella Typhimurium ATCC 14028 assessed as inhibition of biofilm formation after 48 hrs using crystal violet staining by microtiter plate assay2010Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
Structure-activity relationship of brominated 3-alkyl-5-methylene-2(5H)-furanones and alkylmaleic anhydrides as inhibitors of Salmonella biofilm formation and quorum sensing regulated bioluminescence in Vibrio harveyi.
AID378098Antimicrobial activity against Bacillus subtilis at 10 ug2006Journal of natural products, Aug, Volume: 69, Issue:8
Biological activities and 3D QSAR studies of a series of Delisea pulchra (cf. fimbriata) derived natural products.
AID378405Antimicrobial activity against Penicillium oxalicum at 0.01 ug2006Journal of natural products, Aug, Volume: 69, Issue:8
Biological activities and 3D QSAR studies of a series of Delisea pulchra (cf. fimbriata) derived natural products.
AID1062391Inhibition of quorum sensing system in Pseudomonas aeruginosa PAO1 MH602 harboring lasB promoter fused with GFP-ASV assessed as reduction in GFP-ASV reporter protein expression at 266 uM measured every 30 mins relative to control2013Journal of medicinal chemistry, Dec-12, Volume: 56, Issue:23
Design, synthesis, and evaluation of fimbrolide-nitric oxide donor hybrids as antimicrobial agents.
AID469254Inhibition of Escherichia coli LuxS using variable levels of S-ribosyl-homocysteine substrate by UV/Vis absorbance spectroscopy2009Bioorganic & medicinal chemistry letters, Nov-01, Volume: 19, Issue:21
A naturally occurring brominated furanone covalently modifies and inactivates LuxS.
AID378396Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 at 10 ug/ml2006Journal of natural products, Aug, Volume: 69, Issue:8
Biological activities and 3D QSAR studies of a series of Delisea pulchra (cf. fimbriata) derived natural products.
AID378094Antimicrobial activity against Micrococcus luteus at 10 ug2006Journal of natural products, Aug, Volume: 69, Issue:8
Biological activities and 3D QSAR studies of a series of Delisea pulchra (cf. fimbriata) derived natural products.
AID1595289Inhibition of swarming motility of Escherichia coli at 13 ug/cm22019European journal of medicinal chemistry, Jun-01, Volume: 171Insights into the chemistry and therapeutic potential of furanones: A versatile pharmacophore.
AID378095Antimicrobial activity against Micrococcus luteus at 5 ug2006Journal of natural products, Aug, Volume: 69, Issue:8
Biological activities and 3D QSAR studies of a series of Delisea pulchra (cf. fimbriata) derived natural products.
AID580499Antimicrobial activity against Staphylococcus epidermidis 1457 by macrodilution method2009Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
Furanone at subinhibitory concentrations enhances staphylococcal biofilm formation by luxS repression.
AID580508Bactericidal activity against Staphylococcus epidermidis 047 at >10 uM after 18 hrs by CFU count assay2009Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
Furanone at subinhibitory concentrations enhances staphylococcal biofilm formation by luxS repression.
AID469256Inhibition of Escherichia coli LuxS assessed as formation of enzyme-adduct formation by mass spectrometry2009Bioorganic & medicinal chemistry letters, Nov-01, Volume: 19, Issue:21
A naturally occurring brominated furanone covalently modifies and inactivates LuxS.
AID580532Increase in polysaccharide intercellular adhesin in Staphylococcus epidermidis 1457 at 2.5 to 20 uM by ant-PIA staining2009Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
Furanone at subinhibitory concentrations enhances staphylococcal biofilm formation by luxS repression.
AID1062389Inhibition of quorum sensing system in Pseudomonas aeruginosa PAO1 MH602 harboring lasB promoter fused with GFP-ASV assessed as reduction in GFP-ASV reporter protein expression at 29 uM measured every 30 mins relative to control2013Journal of medicinal chemistry, Dec-12, Volume: 56, Issue:23
Design, synthesis, and evaluation of fimbrolide-nitric oxide donor hybrids as antimicrobial agents.
AID378394Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 at 10 ug/ml2006Journal of natural products, Aug, Volume: 69, Issue:8
Biological activities and 3D QSAR studies of a series of Delisea pulchra (cf. fimbriata) derived natural products.
AID580513Induction of biofilm formation in Staphylococcus epidermidis 1457 at 0.1 times MIC to 0.2 X MIC after 18 hrs by crystal violet staining2009Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
Furanone at subinhibitory concentrations enhances staphylococcal biofilm formation by luxS repression.
AID580500Antimicrobial activity against ica gene-deficient Staphylococcus epidermidis 1457 by macrodilution method2009Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
Furanone at subinhibitory concentrations enhances staphylococcal biofilm formation by luxS repression.
AID580505Antimicrobial activity against Bacillus subtilis by macrodilution method2009Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
Furanone at subinhibitory concentrations enhances staphylococcal biofilm formation by luxS repression.
AID580524Increase in biofilm formation in Staphylococcus aureus Newman by crystal violet staining2009Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
Furanone at subinhibitory concentrations enhances staphylococcal biofilm formation by luxS repression.
AID514001Antimicrobial activity against wild type Vibrio harveyi BB1202010Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
Structure-activity relationship of brominated 3-alkyl-5-methylene-2(5H)-furanones and alkylmaleic anhydrides as inhibitors of Salmonella biofilm formation and quorum sensing regulated bioluminescence in Vibrio harveyi.
AID378090Antimicrobial activity against Escherichia coli at 10 ug2006Journal of natural products, Aug, Volume: 69, Issue:8
Biological activities and 3D QSAR studies of a series of Delisea pulchra (cf. fimbriata) derived natural products.
AID378082Cytotoxicity against human KB cells2006Journal of natural products, Aug, Volume: 69, Issue:8
Biological activities and 3D QSAR studies of a series of Delisea pulchra (cf. fimbriata) derived natural products.
AID378100Antimicrobial activity against Bacillus subtilis at 1 ug2006Journal of natural products, Aug, Volume: 69, Issue:8
Biological activities and 3D QSAR studies of a series of Delisea pulchra (cf. fimbriata) derived natural products.
AID580512Bactericidal activity against Staphylococcus epidermidis 1457 at >50 uM after 18 hrs by CFU count assay2009Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
Furanone at subinhibitory concentrations enhances staphylococcal biofilm formation by luxS repression.
AID580515Induction of biofilm formation in ica gene-deficient Staphylococcus epidermidis 1457 after 18 hrs by crystal violet staining2009Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
Furanone at subinhibitory concentrations enhances staphylococcal biofilm formation by luxS repression.
AID580507Bactericidal activity against ica gene-deficient Staphylococcus epidermidis 1457 at >10 uM after 18 hrs by CFU count assay2009Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
Furanone at subinhibitory concentrations enhances staphylococcal biofilm formation by luxS repression.
AID580525Reduction luxS mRNA level in Staphylococcus epidermidis 1457 at 20 uM2009Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
Furanone at subinhibitory concentrations enhances staphylococcal biofilm formation by luxS repression.
AID378088Cytotoxicity against human ZR-75-1 cells2006Journal of natural products, Aug, Volume: 69, Issue:8
Biological activities and 3D QSAR studies of a series of Delisea pulchra (cf. fimbriata) derived natural products.
AID580522Effect on agr quorum sensing system in Staphylococcus epidermidis 1457 assessed as RNA3 expression level at 2.5 to 20 uM2009Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
Furanone at subinhibitory concentrations enhances staphylococcal biofilm formation by luxS repression.
AID378087Cytotoxicity against human LNCAP cells2006Journal of natural products, Aug, Volume: 69, Issue:8
Biological activities and 3D QSAR studies of a series of Delisea pulchra (cf. fimbriata) derived natural products.
AID378092Antimicrobial activity against Escherichia coli at 1 ug2006Journal of natural products, Aug, Volume: 69, Issue:8
Biological activities and 3D QSAR studies of a series of Delisea pulchra (cf. fimbriata) derived natural products.
AID580523Increase in biofilm formation in agr gene-deficient Staphylococcus aureus Newman by crystal violet staining2009Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
Furanone at subinhibitory concentrations enhances staphylococcal biofilm formation by luxS repression.
AID378096Antimicrobial activity against Micrococcus luteus at 1 ug2006Journal of natural products, Aug, Volume: 69, Issue:8
Biological activities and 3D QSAR studies of a series of Delisea pulchra (cf. fimbriata) derived natural products.
AID580519Induction of biofilm formation in Bacillus subtilis after 18 hrs by crystal violet staining2009Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
Furanone at subinhibitory concentrations enhances staphylococcal biofilm formation by luxS repression.
AID580518Induction of biofilm formation in Staphylococcus aureus 113 after 18 hrs by crystal violet staining2009Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
Furanone at subinhibitory concentrations enhances staphylococcal biofilm formation by luxS repression.
AID580510Bactericidal activity against Staphylococcus aureus Newman at >10 uM after 18 hrs by CFU count assay2009Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
Furanone at subinhibitory concentrations enhances staphylococcal biofilm formation by luxS repression.
AID378077Cytotoxicity against human BCA1 cells2006Journal of natural products, Aug, Volume: 69, Issue:8
Biological activities and 3D QSAR studies of a series of Delisea pulchra (cf. fimbriata) derived natural products.
AID1062385Antibacterial activity against Pseudomonas aeruginosa PAO1 MH602 harboring lasB promoter fused with GFP-ASV assessed as growth inhibition at 88 uM measured every 30 mins by GFP-ASV reporter gene assay2013Journal of medicinal chemistry, Dec-12, Volume: 56, Issue:23
Design, synthesis, and evaluation of fimbrolide-nitric oxide donor hybrids as antimicrobial agents.
AID469257Inhibition of Escherichia coli LuxS assessed as induction of Cys126 alkylation by MALDI-MS method2009Bioorganic & medicinal chemistry letters, Nov-01, Volume: 19, Issue:21
A naturally occurring brominated furanone covalently modifies and inactivates LuxS.
AID378084Cytotoxicity against vinblastine-resistant human KB cells2006Journal of natural products, Aug, Volume: 69, Issue:8
Biological activities and 3D QSAR studies of a series of Delisea pulchra (cf. fimbriata) derived natural products.
AID580520Inhibition of biofilm formation of Pseudomonas aeruginosa PAO1 at 0.322 uM to 2.58 mM2009Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
Furanone at subinhibitory concentrations enhances staphylococcal biofilm formation by luxS repression.
AID580521Antimicrobial activity against Pseudomonas aeruginosa PAO1 by macrodilution method2009Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
Furanone at subinhibitory concentrations enhances staphylococcal biofilm formation by luxS repression.
AID1062390Inhibition of quorum sensing system in Pseudomonas aeruginosa PAO1 MH602 harboring lasB promoter fused with GFP-ASV assessed as reduction in GFP-ASV reporter protein expression at 88 uM measured every 30 mins relative to control2013Journal of medicinal chemistry, Dec-12, Volume: 56, Issue:23
Design, synthesis, and evaluation of fimbrolide-nitric oxide donor hybrids as antimicrobial agents.
AID580526Effect on biofilm formation in luxS gene-deficient Staphylococcus epidermidis 1457 at >10 uM by crystal violet staining2009Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
Furanone at subinhibitory concentrations enhances staphylococcal biofilm formation by luxS repression.
AID378091Antimicrobial activity against Escherichia coli at 5 ug2006Journal of natural products, Aug, Volume: 69, Issue:8
Biological activities and 3D QSAR studies of a series of Delisea pulchra (cf. fimbriata) derived natural products.
AID580506Bactericidal activity against Staphylococcus epidermidis 1457 at >10 uM after 18 hrs by CFU count assay2009Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
Furanone at subinhibitory concentrations enhances staphylococcal biofilm formation by luxS repression.
AID514000Inhibition of quorum sensing regulated bioluminescence in wild type Vibrio harveyi BB120 after 5 hrs by luminescence assay2010Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
Structure-activity relationship of brominated 3-alkyl-5-methylene-2(5H)-furanones and alkylmaleic anhydrides as inhibitors of Salmonella biofilm formation and quorum sensing regulated bioluminescence in Vibrio harveyi.
AID580511Bactericidal activity against Staphylococcus aureus 113 at >10 uM after 18 hrs by CFU count assay2009Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
Furanone at subinhibitory concentrations enhances staphylococcal biofilm formation by luxS repression.
AID1595264Antibiofilm activity in Bacillus subtilis assessed as reduction in biofilm thickness at 40 ug/ml incubated for 3 days by confocal microscopy2019European journal of medicinal chemistry, Jun-01, Volume: 171Insights into the chemistry and therapeutic potential of furanones: A versatile pharmacophore.
AID580517Increase in biofilm formation in Staphylococcus aureus Newman after 18 hrs by crystal violet staining2009Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
Furanone at subinhibitory concentrations enhances staphylococcal biofilm formation by luxS repression.
AID378089Cytotoxicity against human U373 cells2006Journal of natural products, Aug, Volume: 69, Issue:8
Biological activities and 3D QSAR studies of a series of Delisea pulchra (cf. fimbriata) derived natural products.
AID378083Cytotoxicity against vinblastine-sensitive human KB cells2006Journal of natural products, Aug, Volume: 69, Issue:8
Biological activities and 3D QSAR studies of a series of Delisea pulchra (cf. fimbriata) derived natural products.
AID1595265Antibacterial activity against Bacillus subtilis assessed as cell viability at 40 ug/ml incubated for 3 days by confocal microscopy2019European journal of medicinal chemistry, Jun-01, Volume: 171Insights into the chemistry and therapeutic potential of furanones: A versatile pharmacophore.
AID580516Induction of biofilm formation in ica gene-deficient Staphylococcus epidermidis 047 after 18 hrs by crystal violet staining2009Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
Furanone at subinhibitory concentrations enhances staphylococcal biofilm formation by luxS repression.
AID1062388Inhibition of quorum sensing system in Pseudomonas aeruginosa PAO1 MH602 harboring lasB promoter fused with GFP-ASV assessed as reduction in GFP-ASV reporter protein expression at 9.8 uM measured every 30 mins relative to control2013Journal of medicinal chemistry, Dec-12, Volume: 56, Issue:23
Design, synthesis, and evaluation of fimbrolide-nitric oxide donor hybrids as antimicrobial agents.
AID580509Bactericidal activity against ica gene-deficient Staphylococcus epidermidis 047 at >10 uM after 18 hrs by CFU count assay2009Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
Furanone at subinhibitory concentrations enhances staphylococcal biofilm formation by luxS repression.
AID378093Antimicrobial activity against Escherichia coli at 0.1 ug2006Journal of natural products, Aug, Volume: 69, Issue:8
Biological activities and 3D QSAR studies of a series of Delisea pulchra (cf. fimbriata) derived natural products.
AID513999Antimicrobial activity against Salmonella Typhimurium ATCC 14028 assessed as effect on planktonic growth at 10 uM after 36 hrs by microtiter plate assay2010Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
Structure-activity relationship of brominated 3-alkyl-5-methylene-2(5H)-furanones and alkylmaleic anhydrides as inhibitors of Salmonella biofilm formation and quorum sensing regulated bioluminescence in Vibrio harveyi.
AID378085Cytotoxicity against mouse P388 cells2006Journal of natural products, Aug, Volume: 69, Issue:8
Biological activities and 3D QSAR studies of a series of Delisea pulchra (cf. fimbriata) derived natural products.
AID580514Increase in biofilm formation in Staphylococcus epidermidis 047 at 0.1 times MIC to 0.2 X MIC after 18 hrs by crystal violet staining2009Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
Furanone at subinhibitory concentrations enhances staphylococcal biofilm formation by luxS repression.
AID378102Antimicrobial activity against Penicillium oxalicum at 10 ug2006Journal of natural products, Aug, Volume: 69, Issue:8
Biological activities and 3D QSAR studies of a series of Delisea pulchra (cf. fimbriata) derived natural products.
AID580504Antimicrobial activity against Staphylococcus aureus Newman by macrodilution method2009Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
Furanone at subinhibitory concentrations enhances staphylococcal biofilm formation by luxS repression.
AID378391Antimicrobial activity against Penicillium oxalicum at 0.1 ug2006Journal of natural products, Aug, Volume: 69, Issue:8
Biological activities and 3D QSAR studies of a series of Delisea pulchra (cf. fimbriata) derived natural products.
AID378103Antimicrobial activity against Penicillium oxalicum at 5 ug2006Journal of natural products, Aug, Volume: 69, Issue:8
Biological activities and 3D QSAR studies of a series of Delisea pulchra (cf. fimbriata) derived natural products.
AID378104Antimicrobial activity against Penicillium oxalicum at 1 ug2006Journal of natural products, Aug, Volume: 69, Issue:8
Biological activities and 3D QSAR studies of a series of Delisea pulchra (cf. fimbriata) derived natural products.
AID469252Inhibition of Escherichia coli LuxS using S-ribosyl-homocysteine substrate at pH 7 after 10 mins by fluorimetric assay2009Bioorganic & medicinal chemistry letters, Nov-01, Volume: 19, Issue:21
A naturally occurring brominated furanone covalently modifies and inactivates LuxS.
AID378097Antimicrobial activity against Micrococcus luteus at 0.1 ug2006Journal of natural products, Aug, Volume: 69, Issue:8
Biological activities and 3D QSAR studies of a series of Delisea pulchra (cf. fimbriata) derived natural products.
AID378101Antimicrobial activity against Bacillus subtilis at 0.1 ug2006Journal of natural products, Aug, Volume: 69, Issue:8
Biological activities and 3D QSAR studies of a series of Delisea pulchra (cf. fimbriata) derived natural products.
AID1062387Inhibition of quorum sensing system in Pseudomonas aeruginosa PAO1 MH602 harboring lasB promoter fused with GFP-ASV assessed as reduction in GFP-ASV reporter protein expression at 3.2 uM measured every 30 mins relative to control2013Journal of medicinal chemistry, Dec-12, Volume: 56, Issue:23
Design, synthesis, and evaluation of fimbrolide-nitric oxide donor hybrids as antimicrobial agents.
AID378079Cytotoxicity against human Lu1 cells2006Journal of natural products, Aug, Volume: 69, Issue:8
Biological activities and 3D QSAR studies of a series of Delisea pulchra (cf. fimbriata) derived natural products.
AID469255Inhibition of Escherichia coli LuxS assessed as induction of covalent modification by UV/Vis absorbance spectroscopy2009Bioorganic & medicinal chemistry letters, Nov-01, Volume: 19, Issue:21
A naturally occurring brominated furanone covalently modifies and inactivates LuxS.
AID513998Antimicrobial activity against Salmonella Typhimurium ATCC 14028 assessed as effect on planktonic growth at 100 uM after 36 hrs by microtiter plate assay2010Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
Structure-activity relationship of brominated 3-alkyl-5-methylene-2(5H)-furanones and alkylmaleic anhydrides as inhibitors of Salmonella biofilm formation and quorum sensing regulated bioluminescence in Vibrio harveyi.
AID580503Antimicrobial activity against Staphylococcus aureus 113 by macrodilution method2009Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
Furanone at subinhibitory concentrations enhances staphylococcal biofilm formation by luxS repression.
AID513997Antimicrobial activity against Salmonella Typhimurium ATCC 14028 assessed as effect on planktonic growth at 250 uM after 36 hrs by microtiter plate assay2010Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
Structure-activity relationship of brominated 3-alkyl-5-methylene-2(5H)-furanones and alkylmaleic anhydrides as inhibitors of Salmonella biofilm formation and quorum sensing regulated bioluminescence in Vibrio harveyi.
AID378078Cytotoxicity against human HT1080 cells2006Journal of natural products, Aug, Volume: 69, Issue:8
Biological activities and 3D QSAR studies of a series of Delisea pulchra (cf. fimbriata) derived natural products.
AID378081Cytotoxicity against human Col1 cells2006Journal of natural products, Aug, Volume: 69, Issue:8
Biological activities and 3D QSAR studies of a series of Delisea pulchra (cf. fimbriata) derived natural products.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (42.86)29.6817
2010's4 (57.14)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.26

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.26 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.34 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.26)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (14.29%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (85.71%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
celecoxib
[no description available]		3.3110organofluorine compound;
pyrazoles;
sulfonamide;
toluenes		cyclooxygenase 2 inhibitor;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug
chloroquine
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.		2.0310aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug
diclofenac
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.. diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.		3.3110amino acid;
aromatic amine;
dichlorobenzene;
monocarboxylic acid;
secondary amino compound		antipyretic;
drug allergen;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic
ibuprofen
Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine		3.3110monocarboxylic acidantipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
environmental contaminant;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
radical scavenger;
xenobiotic
mefloquine hydrochloride
[2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol : An organofluorine compound that consists of quinoline bearing trifluoromethyl substituents at positions 2 and 8 as well as a (2-piperidinyl)hydroxymethyl substituent at position 4.		2.0310organofluorine compound;
piperidines;
quinolines;
secondary alcohol
miconazole
Miconazole: An imidazole antifungal agent that is used topically and by intravenous infusion.. 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole : A member of the class of imidazoles that is 1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethanol in which the hydroxyl hydrogen is replaced by a 2,4-dichlorobenzyl group.. miconazole : A racemate composed of equimolar amounts of (R)- and (S)-miconazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections. It inhibits the synthesis of ergosterol, a critical component of fungal cell membranes.		2.0310dichlorobenzene;
ether;
imidazoles
ofloxacin
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.. 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.. ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.		3.31103-oxo monocarboxylic acid;
N-arylpiperazine;
N-methylpiperazine;
organofluorine compound;
oxazinoquinoline
rofecoxib
[no description available]		3.3110butenolide;
sulfone		analgesic;
cyclooxygenase 2 inhibitor;
non-steroidal anti-inflammatory drug
isosorbide dinitrate
Isosorbide Dinitrate: A vasodilator used in the treatment of ANGINA PECTORIS. Its actions are similar to NITROGLYCERIN but with a slower onset of action.		2.0810glucitol derivative;
nitrate ester		nitric oxide donor;
vasodilator agent
3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2(5h)-furanone
3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2(5H)-furanone: structure given in first source		3.3110
arbutin
hydroquinone O-beta-D-glucopyranoside : A monosaccharide derivative that is hydroquinone attached to a beta-D-glucopyranosyl residue at position 4 via a glycosidic linkage.		3.3110beta-D-glucoside;
monosaccharide derivative		Escherichia coli metabolite;
plant metabolite
ketoconazole
(2R,4S)-ketoconazole : A cis-1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine which dioxolane moiety has (2R,4S)-configuration.		3.3110cis-1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine
quinine
[no description available]		2.0310cinchona alkaloidantimalarial;
muscle relaxant;
non-narcotic analgesic
4-hydroxy-5-methyl-3(2h)-furanone
4-hydroxy-5-methyl-3-furanone : A member of the class of furans that is 5-methyl-2,3-dihydrofuran with a hydroxy group at position 4 and a keto group at position 3.		3.3110cyclic ketone;
enol;
furans		metabolite
amphotericin b
Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.. amphotericin B : A macrolide antibiotic used to treat potentially life-threatening fungal infections.		3.3110antibiotic antifungal drug;
macrolide antibiotic;
polyene antibiotic		antiamoebic agent;
antiprotozoal drug;
bacterial metabolite
furanone c-30
furanone C-30: structure in first source		3.6120
ascorbic acid
Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.		3.3110ascorbic acid;
vitamin C		coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent
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