ascorbic-acid and herniarin

ascorbic-acid has been researched along with herniarin* in 1 studies

Other Studies

1 other study(ies) available for ascorbic-acid and herniarin

Article	Year
Antigenotoxic activities of the natural dietary coumarins umbelliferone, herniarin and 7-isopentenyloxy coumarin on human lymphocytes exposed to oxidative stress. Drug and chemical toxicology, 2014, Volume: 37, Issue:2 The antigenotoxic effects of umbelliferone (UMB), herniarin (HER) and 7-isopentenyloxy coumarin (7-IP), common natural dietary coumarins, were evaluated on the human lymphocyte DNA damage using single-cell gel electrophoresis. H(2)O(2)-induced DNA break was measured based on the percentage of DNA in tail, and the antigenotoxic effects of the tested compounds were compared with that of ascorbic acid (10, 25, 50, 100 and 200 μM). UMB, HER and 7-IP did not show any genotoxicity, as compared to phosphate-buffered saline. Treatment with UMB, HER and 7-IP led to a significant reduction in the percentage of DNA in tail induced by H(2)O(2) (p < 0.001) at all concentrations. The presence of prenyl moiety in the chemical structure of 7-IP may contribute to its better antigenotoxic property, compared to UMB. The results of this study showed that 7-IP possessed the best antigenotoxic activity among the tested compounds. Topics: Adult; Antimutagenic Agents; Ascorbic Acid; Comet Assay; Coumarins; DNA Damage; Dose-Response Relationship, Drug; Humans; Hydrogen Peroxide; Lymphocytes; Oxidative Stress; Umbelliferones	2014

Article

Year

Antigenotoxic activities of the natural dietary coumarins umbelliferone, herniarin and 7-isopentenyloxy coumarin on human lymphocytes exposed to oxidative stress.

Drug and chemical toxicology, 2014, Volume: 37, Issue:2

The antigenotoxic effects of umbelliferone (UMB), herniarin (HER) and 7-isopentenyloxy coumarin (7-IP), common natural dietary coumarins, were evaluated on the human lymphocyte DNA damage using single-cell gel electrophoresis. H(2)O(2)-induced DNA break was measured based on the percentage of DNA in tail, and the antigenotoxic effects of the tested compounds were compared with that of ascorbic acid (10, 25, 50, 100 and 200 μM). UMB, HER and 7-IP did not show any genotoxicity, as compared to phosphate-buffered saline. Treatment with UMB, HER and 7-IP led to a significant reduction in the percentage of DNA in tail induced by H(2)O(2) (p < 0.001) at all concentrations. The presence of prenyl moiety in the chemical structure of 7-IP may contribute to its better antigenotoxic property, compared to UMB. The results of this study showed that 7-IP possessed the best antigenotoxic activity among the tested compounds.

Topics: Adult; Antimutagenic Agents; Ascorbic Acid; Comet Assay; Coumarins; DNA Damage; Dose-Response Relationship, Drug; Humans; Hydrogen Peroxide; Lymphocytes; Oxidative Stress; Umbelliferones

2014