A drug which increases appetite.
ChEBI ID: 50779
| Member | Definition | Class |
|---|---|---|
| cannabigerol | A member of the class of resorcinols that is resorcinol which is substituted by a (2E)-3,7-dimethylocta-2,6-dien-1-yl group at position 2 and by a pentyl group at position 5. It is a natural product found in Cannabis sativa and Helichrysum species. | cannabigerol |
| megestrol | A 3-oxo Delta(4)-steroid that is pregna-4,6-diene-3,20-dione substituted by a methyl group at position 6 and a hydroxy group at position 17. | megestrol |
| megestrol acetate | A steroid ester resulting from the formal condensation of the hydroxy group of megestrol with the carboxy group of acetic acid. It is an appetite stimulant used for the treatment of anorexia and cachexia. Also used for birth control and for the treatment of breast cancer. | megestrol acetate |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 661 (38.41) | 18.7374 |
| 1990's | 380 (22.08) | 18.2507 |
| 2000's | 307 (17.84) | 29.6817 |
| 2010's | 266 (15.46) | 24.3611 |
| 2020's | 107 (6.22) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 435 (20.17%) | 5.53% |
| Reviews | 217 (10.06%) | 6.00% |
| Case Studies | 193 (8.95%) | 4.05% |
| Observational | 13 (0.60%) | 0.25% |
| Other | 1,299 (60.22%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| AR protein | Homo sapiens (human) | Potency | 2.6462 | 10 | 20 |
| Ataxin-2 | Homo sapiens (human) | Potency | 38.5708 | 1 | 1 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 38.5708 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 45.6293 | 1 | 2 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 19.9526 | 1 | 1 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 31.6228 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 12.3018 | 1 | 1 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 8.7090 | 1 | 1 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 0.1053 | 1 | 2 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 70.7946 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 26.8560 | 3 | 5 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 23.5462 | 6 | 11 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 61.6448 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 12.3018 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 0.5805 | 1 | 1 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 11.8701 | 2 | 4 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 0.0704 | 2 | 4 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 12.3018 | 1 | 1 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 7.9433 | 2 | 2 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 12.3018 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 12.3018 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 3.5717 | 1 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 12.8807 | 2 | 4 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 0.7308 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 10.1824 | 1 | 2 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 8.9125 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 66.6712 | 2 | 2 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 13.8006 | 2 | 2 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 18.0040 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 22.0457 | 1 | 2 |
| progesterone receptor | Homo sapiens (human) | Potency | 13.7199 | 3 | 5 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 22.1425 | 2 | 4 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 19.8963 | 2 | 3 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 18.4308 | 2 | 4 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 16.9407 | 2 | 4 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 16.9407 | 2 | 4 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 1.2589 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 26.1011 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 20.2925 | 2 | 4 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 12.5071 | 1 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Androgen receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0300 | 1 | 1 |
| Androgen receptor | Rattus norvegicus (Norway rat) | Ki | 0.0200 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 13.9000 | 2 | 2 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Cannabinoid receptor 1 | Homo sapiens (human) | IC50 | 3.3100 | 1 | 1 |
| Cannabinoid receptor 1 | Homo sapiens (human) | Ki | 1.4190 | 3 | 3 |
| Cannabinoid receptor 1 | Rattus norvegicus (Norway rat) | Ki | 0.4400 | 1 | 1 |
| Cannabinoid receptor 2 | Homo sapiens (human) | IC50 | 3.4600 | 1 | 1 |
| Cannabinoid receptor 2 | Homo sapiens (human) | Ki | 1.2382 | 4 | 4 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Diacylglycerol lipase-alpha | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Glucocorticoid receptor | Homo sapiens (human) | IC50 | 0.0190 | 1 | 1 |
| Glucocorticoid receptor | Homo sapiens (human) | Ki | 0.0088 | 1 | 1 |
| Glycine receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | IC50 | 0.0190 | 1 | 1 |
| Glycine receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Ki | 0.0088 | 1 | 1 |
| Glycine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | IC50 | 0.0190 | 1 | 1 |
| Glycine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Ki | 0.0088 | 1 | 1 |
| Glycine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 | 0.0190 | 1 | 1 |
| Glycine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Ki | 0.0088 | 1 | 1 |
| Glycine receptor subunit beta | Rattus norvegicus (Norway rat) | IC50 | 0.0190 | 1 | 1 |
| Glycine receptor subunit beta | Rattus norvegicus (Norway rat) | Ki | 0.0088 | 1 | 1 |
| Inhibin alpha chain | Homo sapiens (human) | IC50 | 5.2000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| N-acylethanolamine-hydrolyzing acid amidase | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Transient receptor potential cation channel subfamily A member 1 | Homo sapiens (human) | IC50 | 13.0000 | 1 | 1 |
| Transient receptor potential cation channel subfamily A member 1 | Rattus norvegicus (Norway rat) | IC50 | 13.0000 | 1 | 1 |
| Transient receptor potential cation channel subfamily M member 8 | Homo sapiens (human) | IC50 | 0.1600 | 1 | 1 |
| Transient receptor potential cation channel subfamily M member 8 | Rattus norvegicus (Norway rat) | IC50 | 0.1600 | 1 | 1 |
| Transient receptor potential cation channel subfamily V member 1 | Homo sapiens (human) | IC50 | 2.6000 | 2 | 2 |
| Transient receptor potential cation channel subfamily V member 2 | Homo sapiens (human) | IC50 | 1.5000 | 1 | 1 |
| Transient receptor potential cation channel subfamily V member 2 | Rattus norvegicus (Norway rat) | IC50 | 1.5000 | 1 | 1 |
| Transient receptor potential cation channel subfamily V member 3 | Homo sapiens (human) | IC50 | 66.0000 | 1 | 1 |
| Transient receptor potential cation channel subfamily V member 4 | Homo sapiens (human) | IC50 | 1.3000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor gamma | Homo sapiens (human) | EC50 | 15.7000 | 1 | 1 |
| Transient receptor potential cation channel subfamily A member 1 | Homo sapiens (human) | EC50 | 0.7000 | 1 | 1 |
| Transient receptor potential cation channel subfamily A member 1 | Rattus norvegicus (Norway rat) | EC50 | 2.0500 | 2 | 2 |
| Transient receptor potential cation channel subfamily V member 1 | Homo sapiens (human) | EC50 | 1.3000 | 2 | 2 |
| Transient receptor potential cation channel subfamily V member 2 | Homo sapiens (human) | EC50 | 1.7000 | 1 | 1 |
| Transient receptor potential cation channel subfamily V member 2 | Rattus norvegicus (Norway rat) | EC50 | 1.7000 | 1 | 1 |
| Transient receptor potential cation channel subfamily V member 3 | Homo sapiens (human) | EC50 | 1.0000 | 1 | 1 |
| Transient receptor potential cation channel subfamily V member 4 | Homo sapiens (human) | EC50 | 5.1000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Alpha-2A adrenergic receptor | Homo sapiens (human) | EC5 | 0.0020 | 1 | 1 |
| bioA | Mycobacterium tuberculosis UT205 | AC50 | 11.0100 | 1 | 1 |
| Cannabinoid receptor 1 | Homo sapiens (human) | K | 1.0400 | 1 | 1 |
| Cannabinoid receptor 1 | Mus musculus (house mouse) | K | 0.3800 | 1 | 1 |