A sharply elevated, irregularly shaped, progressively enlarging scar resulting from formation of excessive amounts of collagen in the dermis during connective tissue repair. It is differentiated from a hypertrophic scar (CICATRIX, HYPERTROPHIC) in that the former does not spread to surrounding tissues.
| Excerpt | Reference |
|---|
| "Keloids are medically benign, but often psychologically and cosmetically malignant lesions." | ( Kelly, AP, 1978) |
| "Keloids are a benign proliferative growth of dermal collagen usually resulting from an excessive tissue response to skin trauma in predisposed individuals." | ( Doyle-Lloyd, DJ; White, JA, 1991) |
| "Keloids are benign cutaneous tumours characterized by excess deposition of collagen, specifically type I collagen." | ( Peltonen, J; Tan, EM, 1991) |
| "Keloids are rapidly resolved with the use of flurandrenolide tape covered with positive-pressure chin-strap dressings." | ( Fulton, JE, 1991) |
| "Keloid is a disease principally of the human dermis, and occasionally the cornea, appearing as thick scar tissue invading normal skin or cornea and produced by the deposition of excessive amounts of collagen over prolonged periods." | ( Datubo-Brown, DD, 1990) |
| "Keloids are benign fibrous growths that result from an abnormal connective tissue response in certain predisposed individuals." | ( Kelly, AP, 1988) |
| "Keloids are benign dermal tumors that form during an abnormal wound-healing process in genetically susceptible individuals." | ( Rodríguez-Eaton, S; Russell, JD; Russell, SB; Trupin, JS; Trupin, KM, 1988) |
| "Keloids are histologically characterized by an abundance of the extracellular matrix of connective tissue." | ( Abergel, RP; Chu, ML; Lask, G; Matsuoka, LY; Meeker, CA; Minor, RR; Pizzurro, D; Uitto, J, 1985) |
| "Keloids are predominantly fibrous tumors which appear as firm, variably pruritic or tender growths near a site of injury." | ( Murray, JC; Pinnell, SR; Pollack, SV, 1981) |
| "Linear keloids are an unusual manifestation." | ( Scott, AM; Scott, MJ, 1994) |
| "Earlobe keloids are a challenging management problem." | ( DeWitt, DE; Zuber, TJ, 1994) |
| "Keloids are disfiguring deformities that occur after trauma or wounding of the skin, most commonly among blacks." | ( Abrams, BJ; Benedetto, AV; Humeniuk, HM, 1993) |
| "A keloid is a pathological overgrowth of scar expanding beyond the boundaries of the initiating skin wound." | ( Banes, AJ; Calderon, M; Lawrence, WT, 1996) |
| "Keloids are characterized by an overabundant deposition of collagen, and they recur frequently following excision." | ( Bettinger, DA; Cohen, IK; Diegelmann, RF; Yager, DR, 1996) |
| "Keloids are pathological lesions characterized by enhanced expression of extracellular matrix molecules including fibronectin." | ( Eriksson, E; Oliver, N; Sible, JC, 1996) |
| "Keloids are collagenous lesions acquired as a result of abnormal wound heating." | ( Appleton, I; Brown, NJ; Willoughby, DA, 1996) |
| "Keloids are an abnormal response to wound healing distinguished by an overproduction of collagen." | ( Amsberry, J; Broker, BJ; Keane, WM; Pribitkin, EA; Rosen, D; Sailor, L; Schmidt, R, 1996) |
| "Keloids are relatively common sequelae of trauma to the skin of the head and neck." | ( Davis, PT; Lindsey, WH, 1997) |
| "A keloid is a benign tumor that contains excess collagen, primarily type I collagen." | ( diLeonardo, M; Kauh, YC; Mondragon, G; Rouda, S; Tan, EM; Tokarek, R; Tuan, RS, 1997) |
| "Keloids are clinically vexacious scars characterized by a high recurrence rate after excision alone (50-100%)." | ( Bedane, C; Bonnafoux-Clavere, A; Bonnetblanc, JM; Clavere, P; Rousseau, J, 1997) |
| "Treatment of keloids is often disappointing and sometime quite difficult to manage." | ( Bodokh, I; Brun, P, 1996) |
| "Keloids are the result of a dysregulated wound healing process." | ( Fivenson, D; Han, X; Hou, Z; Ladin, D; Olson, J; Saed, GM, 1998) |
| "Keloid is a tissue with an excessive accumulation of collagen." | ( Katz, EP; Marshall, MK; Tanzawa, H; Uzawa, K; Yamauchi, M; Yeowell, HN, 1998) |
| "Keloid is a dermal fibroproliferative tissue of unknown etiology." | ( Akino, K; Fujii, T; Ishihara, H; Ito, M; Kuroda, H; Murakami, R; Namba, H; Ohtsuru, A; Yamashita, S; Yoshimoto, H, 1999) |
| "Histologically, keloids are composed of excessive collagen with an abnormally large number of partially or totally occluded microvessels." | ( Chau, D; Chin, G; Gittes, GK; Lee, T; Longaker, MT; Mehrara, BJ; Rowe, NM; Saadeh, PB; Steinbrech, DS, 1999) |
| "Keloids are exuberant scars, in which collagen, fibronectin and glycosaminoglycans are overdeposited." | ( Prathiba, V; Suryanarayanan, M, 1999) |
| "Keloids are typically excluded from palms and soles." | ( Chipev, CC; Hatch, G; Katz, AE; Siegel, DM; Simman, R; Simon, M, 2000) |
| "Keloids are characterized by a net accumulation of collagen." | ( McCauley, RL; Xue, H; Zhang, W, 2000) |
| "Clinically, keloids are most commonly observed in subjects at ages between 10 and 30 years." | ( Ishihara, H; Namba, H; Ohtsuru, A; Yamashita, S; Yoshimoto, H, 2000) |
| "Keloids are benign dermal tumors, characterized by overgrowth of lesions, invasiveness beyond the original boundary of the insult, and recurrence of lesions." | ( Fujii, T; Fujioka, M; Hirano, A; Ishihara, H; Murakami, R; Namba, H; Ohtsuru, A; Yamashita, S; Yoshimoto, H, 2000) |
| "Unique to humans, keloids are characterized by an accumulation of extracellular matrix components." | ( Chin, GS; Hsu, M; Levinson, H; Liu, W; Longaker, MT; Steinbrech, D, 2000) |
| "Keloid is a dermal fibrotic disease characterized by excessive accumulation of mainly type I collagen in extracellular matrix of the dermis." | ( Hosokawa, N; Kubota, H; Nagata, K; Naitoh, M; Nishimura, Y; Sawada, M; Shirane, H; Tanaka, T, 2001) |
| "Keloids are disfiguring, proliferative scars that represent a pathological response to cutaneous injury." | ( Lim, IJ; Longaker, MT; Phan, TT; Song, C; Tan, WT, 2001) |
| "Keloids are notoriously difficult to treat." | ( Gupta, S; Kumar, B, 2001) |
| "Keloids are a common lesion arising from sites of previous trauma and are a considerable source of morbidity because of continued growth of lesions, pruritus, and physical appearance." | ( Arbiser, JL; Cohen, C; DiCarlo, J; Johnson, D; Kim, A; McAlpine, B; McCall, C; McLaughlin, ER; Quinn, AG, 2001) |
| "Keloids are proliferative fibrous growths that result from an excessive tissue response to skin trauma." | ( Marneros, AG; Norris, JE; Olsen, BR; Reichenberger, E, 2001) |
| "Keloids are benign lesions that represent an exuberant collagen response to injury." | ( Porter, JP, 2002) |
| "Keloids are characterized by the deposition of excessive extracellular-matrix collagen by abnormal fibroblasts in response to cutaneous injury." | ( Bay, BH; Huynh, HT; Lee, ST; Lim, IJ; Longaker, MT; Phan, TT; Qi, R, 2002) |
| "Earlobe keloids are benign, fibrous proliferations that show a high rate of recurrence of up to 80% following surgical excision." | ( Büttemeyer, R; Mall, JW; Müller, JM; Pollmann, C, 2002) |
| "Keloids are benign tumours of the skin." | ( Bock, O; Mrowietz, U, 2002) |
| "Plantar keloids are a management problem as a result of the pain and mechanic restriction with ambulation." | ( Elston, DM; Osswald, SS; Vogel, PS, 2003) |
| "Keloids are benign diseases of the skin." | ( Kutzner, J; Schneider, L; Seegenschmiedt, MH, 2003) |
| "Keloids are the result of aberrant wound healing of human skin after dermal injury." | ( Alani, H; Simman, R; Williams, F, 2003) |
| "Keloids are proliferative dermal growths representing a pathological wound-healing response." | ( Bay, BH; Huynh, H; Lee, ST; Lim, IJ; Longaker, MT; Phan, TT; Qi, R, 2003) |
| "Keloids are characterized by abnormal proliferation of fibroblasts and overproduction of collagen." | ( Chan, SY; Huynh, H; Lee, ST; Nguyen, TT; Phan, TT; See, P; Tran, E, 2003) |
| "Keloids are benign dermal tumors, characterized by invasive growth of fibroblasts and concomitant increased biosynthesis of extracellular matrix components, with unclear etiology." | ( Akiyama-Uchida, Y; Daian, T; Fujii, T; Hirano, A; Ishihara, H; Ohtsuru, A; Rogounovitch, T; Saenko, V; Yamashita, S, 2003) |
| "Keloid is a fibrotic skin disorder that results in an excessive deposition of extracellular matrix, which is associated with altered-expression of or -responses to TGF-beta in dermal fibroblasts." | ( Hasegawa, T; Nakao, A; Ogawa, H; Sumiyoshi, K; Tsuboi, R, 2003) |
| "Keloid is a benign, well-demarcated area of fibrous tissue overgrowth that extends beyond the original defect." | ( Al-Dhalimi, MA; Sharquie, KE, 2003) |
| "Keloid is an intricate lesion that is probably modulated by interplay of many genes." | ( Chen, W; Fu, X; Sheng, Z; Sun, T; Sun, X; Zhao, Z, 2003) |
| "Keloids are benign fibrous growths with characteristic clinical features, whose underlying pathogenic mechanisms are not fully understood." | ( Aschoff, R; Hackert, I; Sebastian, G, 2003) |
| "Keloids are benign mesenchymal tumours, usually present at and extending beyond the margins of sites of previous injury." | ( Berman, B; Jacob, SE; Nassiri, M; Vincek, V, 2003) |
| "Keloids are characterized as an "overexuberant" healing response in which disequilibrium between production and catabolism of extracellular matrix (ECM) occurs." | ( Akhondzadeh, A; Ann, DK; Duong, HS; Le, AD; Messadi, DV; Wu, Y; Zhang, Q, 2004) |
| "Keloids are an excessive accumulation of extracellular matrix." | ( Ann, DK; Bertolami, CN; Kelly, AP; Le, AD; Messadi, DV; Tuan, TL; Wu, Y; Zhang, Q, 2003) |
| "Keloids are often resistant to treatment, causing much suffering to the patient." | ( Chang, SE; Choi, JH; Kim, KJ; Lim, YJ; Moon, KC; Ro, KH; Sung, KJ, 2004) |
| "Keloids are skin abnormalities that are characterized by excessive deposition of collagen bundles in the dermis." | ( Harii, K; Kitano, Y; Okazaki, M; Uchida, G; Yoshimura, K, 2003) |
| "Keloids are skin fibrotic conditions characterized by an excess accumulation of extracellular matrix (ECM) components secondary to trauma or surgical injuries." | ( Ann, DK; Bertolami, CN; Chau, CH; Le, AD; Wu, Y; Zhang, Q, 2004) |
| "Keloids are benign, but sometimes painful and/or pruritic, proliferative growths of dermal collagen, usually resulting from excessive tissue response to trauma." | ( Kelly, AP, 2004) |
| "Keloids are proliferative fibrous growths that result from an excessive tissue response to skin trauma." | ( Marneros, AG; Norris, JE; Olsen, BR; Reichenberger, E; Watanabe, S, 2004) |
| "Keloids are a major cause of morbidity, and arise after operation, injury, or cutaneous infection." | ( Arbiser, JL; Brown, LF; Cohen, C; Gira, AK; Washington, CV, 2004) |
| "Keloid is an intricate lesion that is probably regulated by many genes." | ( Chen, W; Fu, XB; Ge, SL; Sheng, ZY; Sun, XQ; Zhao, ZL; Zhou, G, 2004) |
| "Keloid is a complicated lesion with many genes involved." | ( Chen, W; Fu, XB; Ge, SL; Sheng, ZY; Sun, XQ; Zhao, ZL; Zhou, G, 2004) |
| "Keloids are benign skin tumors that develop following wounding." | ( Ciarmiello, LF; De Felice, B; Nacca, M; Pinelli, C; Wilson, RR, 2004) |
| "Earlobe keloids are commonly encountered in dermatological practice and often prove to be recurrent, despite a variety of treatment options." | ( Dinh, Q; Richards, S; Veness, M, 2004) |
| "Keloids are characterized as an "over-exuberant" healing response resulting in a disproportionate extracellular matrix (ECM) accumulation and tissue fibrosis." | ( Doung, HS; Kelly, AP; Le, AD; Messadi, DV; Reichenberger, E; Tuan, TL; Zhang, Q, 2004) |
| "The blood supply to keloids is inadequate, and this persists." | ( Furuya, E; Oba, S; Ueda, K; Yasuda, Y, 2004) |
| "Keloids are characterized by abnormal proliferation and overproduction of extracellular matrix." | ( Chan, SY; Lee, ST; Lim, IJ; Longaker, MT; Phan, TT; Tan, EK, 2004) |
| "Keloid is a dermal fibroproliferative lesion of unknown etiology that commonly recurs after surgical excision." | ( Ghazizadeh, M; Hirai, T; Hyakusoku, H; Kawanami, O; Shimizu, H; Tosa, M, 2005) |
| "Keloids are more likely to develop when ears are pierced after age 11 than before age 11." | ( Davis, LS; Lane, JE; Waller, JL, 2005) |
| "Keloids are common lesions arising from sites of a previous trauma, and are distinguishable from scars by the presence of continuous growth over the borders of the original injury." | ( Khorshid, FA, 2005) |
| "Since keloids are common in humans, hypertrophic scars rather than keloids were observed in animal skin wounds." | ( Khorshid, FA, 2005) |
| "Keloids are benign skin tumours occurring during wound healing in genetically predisposed patients." | ( Bayat, A; Bock, O; Ferguson, MW; Mrowietz, U; Yu, H; Zitron, S, 2005) |
| "A keloid is a specific skin lesion that expands beyond the boundaries of the original injury as it heals." | ( Fujiwara, M; Muragaki, Y; Ooshima, A, 2005) |
| "Keloids are disfiguring, proliferative scars that are a pathologic response to cutaneous injury." | ( Chiu, LL; Karamzadeh, A; Sun, CH; Torkian, B; Tromberg, B; Wong, BJ; Yeh, AT, 2005) |
| "Keloids are tumor-like lesions that result from excessive scar formation during healing of wounds." | ( Fujiwara, M; Muragaki, Y; Ooshima, A, 2005) |
| "Keloids are a dermal fibrotic disease whose etiology remains totally unknown and for which there is no successful treatment." | ( Ikeda, M; Kubota, H; Nagata, K; Naitoh, M; Shirane, H; Suzuki, S; Tanaka, T, 2005) |
| "As treatment of keloids is mainly a cosmetic indication, the authors investigated, beyond the recurrence rate, the patients' satisfaction with the result and its correlation with objective medical findings." | ( Böttcher, HD; Fraunholz, IB; Gerstenhauer, A, 2005) |
| "Keloids are a hyperproliferative response of connective tissue in response to trauma." | ( Blazić, TM; Brajac, I, 2006) |
| "Keloids are defined as excessive scar tissue formation extending beyond the area of the original skin injury and occurring in predisposed individuals." | ( Krieg, T; Marneros, AG, 2004) |
| "Keloids are benign cutaneous lesions that result from excessive collagen synthesis and deposition." | ( Fikrle, T; Pizinger, K, 2005) |
| "Keloids are proliferative growths of dermal collagen, usually resulting from excessive tissue response during wound healing." | ( Bay, BH; Lim, D; Phan, TT; Yip, GW, 2006) |
| "Keloids are exuberant, disfiguring scars that result from an abnormal healing process." | ( Al-Attar, A; Davison, SP; Kauffman, LC; Mess, S, 2006) |
| "Keloids are abnormal fibrous growths of the dermis that develop only in response to wounding and represent a form of benign skin tumor." | ( Longaker, MT; Xia, W; Yang, GP, 2006) |
| "Keloids are benign and occur secondary to an imbalance between the synthesis of extracellular matrix and its degradation." | ( Deleuze, JP; Grandjean, FX; Heymans, O; Nickers, P; Schmitz, C; Smeets, L, 2006) |
| "Keloids are benign tumors that occur only in response to injury, for which there is no effective treatment." | ( Lim, IJ; Longaker, MT; Phan, TT; Xia, W; Yang, GP, 2006) |
| "Keloids are common benign tumors of the dermis, typically arising after insult to the skin." | ( Childs, CC; Fuller, CD; Herman, TS; Jones, K; Luh, JY; Miller, AR; Thomas, CR; Tolcher, AW, 2006) |
| "Keloids are characterized by increased fibroblast activity in the setting of an altered cytokine profile." | ( Stashower, ME, 2006) |
| "Keloids are benign skin tumours occurring during wound healing in genetically predisposed patients." | ( Bayat, A; Bock, O; Ferguson, MW; Mrowietz, U; Yu, H, 2006) |
| "Keloids are benign hyperproliferative growths of dermal collagen that usually result from excessive tissue response to skin trauma." | ( Erdemir, F; Gokce, O; Kadioglu, A; Kilicaslan, I; Parlaktas, BS; Sanli, O; Uluocak, N, 2006) |
| "Keloids are fibrotic lesions that are a result of an abnormal wound-healing process that lacks control of the mechanisms that regulate tissue repair and regeneration." | ( Kim, JY; Stewart, CE, 2006) |
| "Keloids are cosmetically devastating lesions with considerable morbidity." | ( Uitto, J, 2007) |
| "Keloids are benign tumors that usually develop as an excessive healing response to injury." | ( Bukvić-Mokos, Z; Lipozencić, J; Marinović, B, 2006) |
| "Keloids are defined as dermal fibrotic lesions which are considered an aberration of the wound healing process." | ( Altmeyer, P; Bechara, FG; Boorboor, P; Hoffmann, K; Mann, B; Sand, D; Sand, M, 2007) |
| "Keloid is a dermal fibroproliferative disorder characterized by excessive deposition of extracellular matrix (ECM) components such as collagen, glycoproteins and fibronectin." | ( Aalami, O; Do, DV; Khoo, YT; Lim, IJ; Mukhopadhyay, A; Ong, CT; Phan, TT, 2007) |
| "Keloids are special type of skin lesions arising from sites of previous trauma." | ( Brudnik, U; Podolec-Rubiś, M; Wojas-Pelc, A, 2006) |
| "Keloid is characterized by excessive collagen accumulation, but the mechanism of keloid formation remains unknown, and none of the treatment modalities are consistently effective." | ( Cen, Y; Chen, JJ; Liu, XX; Wu, DM; Yu, R; Zhao, S, 2007) |
| "Keloid is characterized with disproportionate extracellular matrix accumulation and fibroblast proliferation." | ( Cai, J; Xu, B; Zhang, J; Zhao, Y; Zhu, G, 2007) |
| "Keloids are abnormal wound reactions of connective tissue." | ( Froelich, K; Hagen, R; Kleinsasser, N; Staudenmaier, R, 2007) |
| "Keloids are benign fibroproliferative diseases of unknown aetiology." | ( Bayat, A; Jagadeesan, J, 2007) |
| "Keloids are benign fibrous growths that appear after surgery, trauma or "spontaneously" as a consequence of microtrauma in predisposed patients." | ( Karrer, S, 2007) |
| "Keloid is a hypertrophic scar that may arise within 6 months after injury in susceptible individuals." | ( Bölke, E; Budach, W; Gripp, S; Matuschek, C; Orth, K; Peiper, M; Schwarz, A, 2007) |
| "Keloids are proliferative dermal growths representing a pathologic wound healing response." | ( Kong, W; Lim, IJ; Longaker, MT; Phan, TT; Wang, Z; Xia, W; Yang, GP, 2007) |
| "Keloids are benign tumors of the dermis that form during a protracted wound healing process." | ( Boone, BE; Opalenik, SR; Russell, SB; Smith, JC; Williams, SM, 2008) |
| "Keloids are well-defined fibrous tissue overgrowths extending beyond the original defects." | ( Bhanot, A; Dewan, SP; Kaur, A; Sharma, S, 2007) |
| "Keloids are pathologic scars afflicting a large segment of our population and for which there is no definitive therapy." | ( Butler, PD; Longaker, MT; Ly, DP; Yang, GP, 2008) |
| "Keloids are a frequent finding after physical trauma." | ( Chrisostomidis, C; Chrisostomidis, G; Dimitroulis, D; Frangoulis, M; Konofaos, P; Papadopoulos, O; Vasilopoulou, A, 2008) |
| "Keloid is a benign dermal tumor characterized by proliferation of dermal fibroblasts and overproduction of extracellular matrix (ECM)." | ( Hirano, A; Makino, S; Mitsutake, N; Nakashima, M; Ohtsuru, A; Saenko, VA; Tanaka, K; Umezawa, K; Yamashita, S, 2008) |
| "Keloids are benign skin tumors characterized by collagen accumulation and hyperproliferation of fibroblasts." | ( Jun, EK; Kim, B; Kim, H; Moon, JH; Noh, JY; Oh, C; Oh, S; Park, G; Song, HJ; Yoon, BS; You, S, 2008) |
| "Reports of corneal keloids are rare, with fewer than 80 cases published since the first case was documented in 1865." | ( Kai, S; Panda, A; Sen, S; Vanathi, M, 2008) |
| "Keloids are tumor-like skin scars that grow as a result of the aberrant healing of skin injuries, with no effective treatment." | ( Benya, PD; Chang, R; Ho, W; Hwu, P; Tuan, TL; Wysocki, A; Yiu, P, 2008) |
| "Keloids are considered to be benign hyperproliferative growths of dense fibrous tissue and overabundant deposition of disorganized, thick, hyalinized collagen that result from an abnormal tissue response to cutaneous injury." | ( De Oliveira Moura Cardoso, G; Morosolli, AR; Murilo-Santos, L; Niccoli-Filho, W, 2008) |
| "The pathogenesis of keloid is poorly understood." | ( Akino, K; Akita, S; Hayashi, T; Hirano, A; Mineda, T; Yakabe, A, 2008) |
| "Keloids are benign skin tumors and are the effect of a dysregulated wound-healing process in genetically predisposed patients." | ( De Felice, B; Garbi, C; Santillo, A; Santoriello, M; Wilson, RR, 2009) |
| "Keloids are a common presenting complaint in the primary care clinic." | ( Aziz, N; Davidson, S; Khachemoune, A; Rashid, RM, 2009) |
| "Keloids are raised reddish nodules that develop at the site of an injury." | ( Alyanak, A; Guven, E; Yazar, M; Yigit, B, 2009) |
| "Keloids are characterized by benign proliferation of fibroblasts in the setting of an altered cytokine profile, with a high recurrence rate after surgical treatment." | ( Cação, FM; Messina, MC; Tanaka, V, 2009) |
| "Keloid is characterized by excessive deposition of collagen, resulting from aberrant extracellular matrix (ECM) production and degradation." | ( Akasaka, Y; Imaizumi, R; Inomata, N; Ishikawa, Y; Ito, K; Maruyama, Y; Okada, E, 2009) |
| "Keloids are distinguished by substantial deposition of collagen in the dermis, resulting in an imbalanced production and aggregation of extra cellular matrix." | ( Gao, WY; Guo, SZ; Han, Y; Li, X; Li, Y; Lu, KH; Ma, XJ; Xiao, B; Yan, L; Yi, CG; Zhang, GY; Zheng, Y, 2009) |
| "Keloids are scars, unique to humans, that grow beyond the boundaries of a cutaneous injury, inflammation, burn, or surgical incision." | ( Kelly, AP, 2009) |
| "Keloids are a common form of pathologic wound healing characterized by excessive production of extracellular matrix." | ( Butler, PD; Koong, AC; Longaker, MT; Ly, DP; Wang, Z; Yang, GP, 2011) |
| "Keloids are benign fibroproliferative tumors but often cause serious cosmetic problems." | ( Adam, S; Lari, N; Morand, JJ; Salles, F; Thiéry, G, 2009) |
| "Keloids are recognized as benign tumours characterized by fibroblastic proliferation and accumulation of extracellular matrix, especially collagen deposition." | ( He, S; Huang, W; Liu, X; Roberts, MS; Xu, S; Yang, S; Yang, Y; Zhang, X, 2010) |
| "Keloids are benign skin tumors that are the effect of a dysregulated wound-healing process in genetically predisposed patients." | ( De Felice, B; Nacca, M; Wilson, RR, 2009) |
| "Keloid is a fibrotic disease characterized by abnormal accumulation of extracellular matrix in the dermis." | ( Ikeda, M; Ishiko, T; Kubota, H; Kurokawa, M; Nagata, K; Naitoh, M; Nakamura, T; Suzuki, S; Utani, A; Yamawaki, S; Yoshikawa, K, 2009) |
| "Keloids are associated with small-fiber neuropathy and typically present with itching, pain, and allodynia." | ( Dave, S; Lippincott, B; Uyesugi, B, 2010) |
| "Keloids are benign fibroproliferative dermal tumors of unknown etiology." | ( Cai, LQ; He, SM; Li, Y; Lu, WS; Quan, C; Wang, JF; Wang, ZX; Xiao, FL; Yang, S; Zhang, XJ, 2010) |
| "These keloids are highly resistant for treatment and are followed by severe cosmetic implications." | ( Amir, A; Barnea, Y; Ben-Yosef, R; Gur, E; Leshem, D; Miller, E; Shafir, R; Stahl, S; Weiss, J; Zaretski, A, 2010) |
| "Keloids are fibrous overgrowth induced by cutaneous injury." | ( Arbiser, JL; Chai, CY; Chen, GS; Govindarajan, B; Hong, CH; Lee, CH; Liao, WT; Lin, YF; Shan, WJ; Yu, HS, 2010) |
| "Large and multiple keloids are difficult to treat radically and are currently only treatable by multimodal therapies that aim to relieve symptoms." | ( Ogawa, R, 2010) |
| "Keloids are pathological scars and, despite numerous available treatment modalities, continue to plague physicians and patients." | ( Do, DV; Khoo, YT; Lim, IJ; Masilamani, J; Mukhopadhyay, A; Ong, CT; Phan, TT, 2010) |
| "Keloids are a response to wound healing that occurs due to hyperproliferation of dermal collagen in response to skin injury (Olabanji et al, Surg Pract." | ( Brown, NA; Ortega, FR, 2010) |
| "Keloids are common abnormal raised fibroproliferative lesions that can occur following even minor cutaneous trauma." | ( Cai, LQ; Li, Y; Lu, WS; Sun, LD; Wang, JF; Wang, ZX; Yang, S; Zhang, WY; Zhang, XJ; Zhu, F; Zuo, XB, 2010) |
| "Keloids are benign dermal tumors that form during wound healing in genetically susceptible individuals." | ( Broquist, AH; Gayden, AE; Nanney, LB; Opalenik, SR; Raju, L; Russell, JD; Russell, SB; Trupin, KM; Williams, SM, 2010) |
| "Keloids are the result of a dysfunctional scarring process that leads to excessive deposition of extracellular matrix in susceptible individuals, causing them physical, psychological, and social discomfort." | ( Bonatti, S; Ferreira, AC; Ferreira, LM; Furtado, F; Hochman, B, 2010) |
| "Auricular keloids are very frequent and often have a peculiar response to therapy." | ( Caccialanza, M; Piccinno, R; Recalcati, S, 2011) |
| "The spontaneous keloids are lesions rarely described in caucasoid subjects." | ( Boloorchi, A; Gasnier, P; Hu, W; Kerfant, N; Uguen, A, 2011) |
| "Keloid is a dermal fibroproliferative growth that results from dysfunction of the wound healing processes." | ( Chung, S; Hosono, N; Kamatani, N; Kawaguchi, T; Kubo, M; Nakamura, Y; Nakashima, M; Takahashi, A; Tsunoda, T; Zembutsu, H, 2010) |
| "Keloid is a fibrotic disease characterized by abnormal accumulation of extracellular matrix (ECM) in the dermis." | ( Chang, CC; Chen, MJ; Hsu, YC; Ko, SY; Yu, YM, 2010) |
| "Keloids are fibroproliferative disorders characterized by increased deposition of extracellular matrix components." | ( Cao, X; Chan, SY; Do, DV; Khoo, YT; Lim, CP; Lim, IJ; Masilamani, J; Mukhopadhyay, A; Ong, CT; Phan, TT; Vincent, AS; Wong, PK, 2011) |
| "The progression of keloids is characterized by increased deposition of extracellular matrix proteins, invasion into the surrounding healthy skin and inflammation." | ( Bayat, A; Dienus, K; Gilmore, BF; Seifert, O, 2010) |
| "Keloid is a common complication of the wound healing process." | ( Ayuob, NN; Hajrah, NH; Shaker, SA, 2011) |
| "Keloids are fibrotic lesions resulting from abnormal wound healing." | ( Gupta, M; Narang, T, 2011) |
| "Keloids are fibroproliferative dermal lesions characterized by the proliferation of fibroblasts and the formation of excess scar tissue, for which no effective treatment exists." | ( Huang, Q; Huang, RL; Liang, J; Peng, Z; Wu, ZX; Zhang, PH, 2011) |
| "Keloids are found only in humans and the underlying biochemical mechanisms of their pathogenesis remain unknown." | ( Chua, AW; Fu, Z; Gan, SU; Han, HC; Ma, D; Phan, TT; Sabapathy, K; Song, C, 2011) |
| "Keloids are common abnormal raised fibroproliferative lesions that can occur following even minor cutaneous trauma." | ( Cai, LQ; Li, Y; Lu, WS; Sun, LD; Wang, ZX; Yang, S; Zhang, XJ; Zheng, HF; Zhu, F; Zuo, XB, 2011) |
| "Keloids are a controllable condition when treated with combination therapy, involving surgical excision with postoperative irradiation and early conservative treatment after the detection of recurrence." | ( Ishiko, T; Muneuchi, G; Naitoh, M; Suzuki, S; Yamawaki, S, 2011) |
| "Keloids are protrusive claw-like scars that have a propensity to recur even after surgery, and its molecular etiology remains elusive." | ( Ooi, BN; Phan, TT, 2011) |
| "Keloids are often refractive to treatment, and recurrences occur quite frequently." | ( Fruth, K; Gouveris, H; Kuelkens, C; Mann, WJ, 2011) |
| "A keloid is a fibrous tumor produced by fibroblast hyperproliferation and excessive collagen accumulation due to overproduction of transforming growth factor β1 (TGF-β1)." | ( Budiyanto, A; Radiono, S; Soebono, H; Wirohadidjojo, YW, 2011) |
| "Keloids are benign skin tumours occurring during wound healing in genetically predisposed patients." | ( Cao, J; Chen, H; Li, J; Li, M; Tu, Y; Wang, L; Wu, Z; Xiao, X; Yang, Y; Yu, Y, 2011) |
| "Keloids are aesthetically disfiguring and severely disabling." | ( Ghafarian Shirazi, HR; Hatamipour, E; Hatamipour, M; Mehrabi, S, 2011) |
| "Large and multiple keloids are difficult to treat radically and are currently only treatable by multimodal therapies that aim to relieve symptoms." | ( Cummings, I; Pai, VB, 2011) |
| "Keloids are pathologic proliferations of the dermal layer of the skin resulting from excessive collagen production and deposition." | ( Lee, WJ; Park, SE; Rah, DK, 2011) |
| "Keloid is a type of scar which extends beyond the boundaries of the original wound." | ( Gan, SH; Halim, AS; Nurul Syazana, MS; Shamsuddin, S, 2011) |
| "In the event that a keloid is presented in isolation, chronic osteomyelitis should be considered as a differential diagnosis, and a high index of suspicion is required in order to establish the diagnosis." | ( Olabanji, JK; Oladele, AO; Orimolade, EA; Yusuf, MB, 2011) |
| "Keloid is a clinically intractable disease that causes disfigurement, itching, and pain due to abnormal proliferation of fibroblasts and production of collagen." | ( Maeda, T; Matsumura, H; Saito, M; Setoguchi, Y; Tsuboi, R; Yamazaki, M, 2012) |
| "Keloid is a common skin condition, especially in people of Asian and African decent." | ( Nie, Z, 2011) |
| "Keloids are benign tumours composed of fibrous tissue produced during excessive tissue repair triggered by minor injury, trauma or surgical incision." | ( Bux, S; Madaree, A, 2012) |
| "Keloid is regarded as a fibroproliferative disorder with excessive accumulation of extracellular matrix." | ( Cen, Y; Chen, JJ; Duan, WQ; Jin, PS; Liu, Y; Wang, HS; Xu, XW; Zhao, S, 2011) |
| "Keloids are manifestations of abnormal wound repair with unresolved clinical complications." | ( Jayaraman, M; Korrapati, PS; Krishnaswamy, VR; Mogili, NS; Rajaram, R; Venkatraman, A, 2012) |
| "Keloids are a fibroproliferative disease due to abnormal wound healing process after skin injury." | ( Hirano, A; Kashiyama, K; Matsuse, M; Mitsutake, N; Ogi, T; Saenko, VA; Ujifuku, K; Utani, A; Yamashita, S, 2012) |
| "Keloid is a specific skin scar that expands beyond the boundaries of the original injury as it heals." | ( Bian, D; Dai, Y; Gong, Z; Lu, Q; Song, J; Wei, Z; Xia, Y; Xu, H; Xu, Z, 2012) |
| "Clinically, keloids are defined as scars that invade adjacent healthy tissue and are caused by tissue injury; however, the clear distinction relating keloids to wound healing or to cancer remains elusive." | ( Day, PJ; Javad, F, 2012) |
| "Keloids are characterized by extreme fibroblastic overgrowth of unknown pathogenesis after skin injury." | ( Bambach, I; Cerroni, L; Heitzer, E; Schmidbauer, U; Seidl, H; Wolf, P, 2012) |
| "Keloids are benign dermal tumors characterized by fibroblastic proliferation and excessive accumulation of collagen." | ( Fan, DL; Guo, S; Han, SY; Wang, YX; Zhao, WJ, 2012) |
| "Keloids are defined as excessive scar tissue formation extending beyond the area of the original skin injury and occurring in predisposed individuals." | ( Guglielmi, G; Parisi, S; Scaramuzzi, G; Simeone, A; Troiano, M, 2011) |
| " Keloid is a unique proliferative disorder of fibroblasts resulting from derailment of the typical wound healing process." | ( Fang, AH; Lan, CC; Wu, CS; Wu, PH, 2012) |
| "Morbidity of the keloid is high, given the frequent recurrences and unpredictable." | ( Allah, KC; Assi Djè Bi Djè, V; Kossoko, H; Richard Kadio, M; Yéo, S, 2013) |
| "The keloid is not a homogenous biological entity." | ( Allah, KC; Assi Djè Bi Djè, V; Kossoko, H; Richard Kadio, M; Yéo, S, 2013) |
| "Keloids are thick fibrous scars that are refractory to treatment and unique to humans." | ( Boyce, ST; Glaser, K; Hahn, JM; McFarland, KL; Supp, DM, 2012) |
| "Keloid is a complex condition with environmental and genetic risk-contributing factors." | ( Emami, A; Halim, AS; Kannan, TP; Khoo, TL; Salahshourifar, I; Yussof, SJ, 2012) |
| "Keloid is the result of excessive deposition of collagen in the dermis and subcutaneous tissues." | ( Demirdover, C; Oztan, HY; Sahin, B; Vayvada, H, 2013) |
| "Keloids are the result of excessive scar tissue formation." | ( Bureik, D; Dombrowski, Y; Gauglitz, GG; Pavicic, T; Ruzicka, T; Schauber, J, 2012) |
| "Keloids are benign, fibroproliferative growths that occur as a result of dermal injury in ~15% of the population." | ( Brissett, AE; Naylor, MC, 2012) |
| "Keloids are characterised by the excessive accumulation of extracellular matrix (ECM), especially overabundant collagen formation." | ( Bae, GY; Bahk, YY; Cha, HJ; Chin, YW; Kim, JJ; Kim, WS; Lee, JS; Min, HG, 2013) |
| "Earlobe keloids are benign, fibrous proliferations that occur in predisposed persons at sites of cutaneous injury." | ( Careta, MF; Fortes, AC; Maruta, CW; Messina, MC, 2013) |
| "Keloids are a proliferative fibrotic disease characterized by abnormal accumulation of extracellular matrix in the dermis." | ( Fujita, H; Ikeda, M; Ishiko, T; Kubota, H; Kurahashi, Y; Naitoh, M; Suzuki, S; Yamaguchi, H; Yamawaki, S; Yoshikawa, K, 2013) |
| "Keloids are managed using a variety of treatments, primarily triamcinolone and excision or destruction of a lesion." | ( Davis, SA; Feldman, SR; McMichael, AJ, 2013) |
| "Treatment of keloids is a therapeutic challenge." | ( Ang, CC; Kwok, C; Tay, YK, 2013) |
| "Keloid is characterized by fibroblastic cell proliferation and abundant collagen synthesis." | ( Egawa, S; Ghazizadeh, M; Hyakusoku, H; Igota, S; Murakami, M; Shimizu, H; Tosa, M, 2013) |
| "Keloids are characterized by the vigorously continuous production of extracellular matrix protein and aberrant cytokine activity in the dermis." | ( Chen, YL; Chien, HF; Hung, LY; Lee, CW; Liang, CJ; Pu, CM; Tsai, JS; Wang, SH; Yen, FL; Yen, YH, 2013) |
| "Keloid is a clinically intractable fibro-proliferative disease that spreads beyond the original scar or lesion." | ( Burm, JS; Lee, KW; Yang, WY, 2013) |
| "Keloids are considered aberrations of the wound healing process, and various treatment regimens are described depending on the morphology and size of the lesion." | ( Yüzbaşıoğlu, E, 2013) |
| "Keloids are common cutaneous pathological scars that are characterised by the histological accumulation of fibroblasts, collagen fibres, and clinically significant invasive growth." | ( Huang, C; Ogawa, R, 2013) |
| "Keloids are the result of an overgrowth of dense fibrous tissue that usually develops after healing of a skin injury." | ( Kundu, RV; Love, PB, 2013) |
| "Keloid is benign fibroproliferative dermal tumors with unknown etiology." | ( Cheng, H; Ding, Y; Gao, J; Ha, W; Hou, J; Li, P; Liu, J; Liu, Y; Qian, F; Sheng, Y; Sun, L; Tang, H; Wang, J; Wang, W; Wang, Y; Wu, B; Yang, S; Yuan, X; Zhai, Y; Zhang, X; Zhou, F; Zhu, F; Zuo, X, 2013) |
| "Keloids are tumor-like skin scars that grow as a result of the aberrant healing of skin injuries, with no effective treatment." | ( Bai, Y; Cao, M; Li, C; Liu, H; Xu, Y; Yao, H; Zuo, X, 2013) |
| "Keloids are fibroproliferative disorders that are characterized by histological accumulation of collagens and fibroblasts, refractory clinical symptoms such as itching, topical invasiveness, and frequent postsurgical recurrence." | ( Huang, C; Ogawa, R, 2013) |
| "Keloids are tumour-like scars that appear some years after the original wound, and which spread beyond the limits of the scar." | ( Escudero Nafs, FJ; Pérez-Espadero, A, 2013) |
| "Keloids are an overgrowth of fibrotic tissue outside the original boundaries of an injury and occur secondary to defective wound healing." | ( Jagdeo, JR; Lev-Tov, H; Mamalis, AD; Nguyen, DH, 2014) |
| "Keloids are defined as overgrowths of scar tissue resulting from abnormal wound healing." | ( Akaishi, S; Aoki, M; Dohi, T; Hyakusoku, H; Miyake, K; Ogawa, R; Shimada, T, 2014) |
| "Keloid is a disease that is difficult to cure because of its high recurrence rate after chemotherapy or radiotherapy, therefore it is considered as a benign skin tumor." | ( Chai, G; Liu, W; Qu, M; Song, N; Wu, X, 2013) |
| "Keloids are scars that extend beyond the borders of the original wound." | ( Li, W; Liu, Z; Wang, X; Wang, Y, 2014) |
| "Keloids are fibroproliferative disorders characterized by exuberant extracellular matrix deposition and transforming growth factor (TGF)-β/Smad pathway plays a pivotal role in keloid pathogenesis." | ( Bian, D; Dai, Y; Dou, Y; Gong, Z; Tan, Q; Wu, X; Xia, Y; Yang, Y; Zhang, J, 2013) |
| "Keloids are firm rubbery growths that grow beyond the boundaries of human wounds and their treatment has met with limited success." | ( Biswas, A; Bongso, A; Choolani, M; Fong, CY; Srinivasan, A; Subramanian, A, 2014) |
| "Keloid is induced by a pathological wound healing response, and hepatocyte growth factor (HGF) is known to be involved in tissue repair via the activation of its primary receptor, c-Met." | ( Jin, Z, 2014) |
| "Keloids are slow growing neoplasms characterized by benign proliferation of fibroblasts that is due, at least in part, to altered cytokine profiles." | ( Bakry, OA; Basha, MA; El Meadawy, I; Samaka, RM; Tharwat, A, 2014) |
| "Keloid is a kind of pathological scar of skin, which would seriously impair patient's quality of life." | ( Wang, HM; Xu, JH; Xu, X, 2013) |
| "Keloids are a burden for patients due to physical, aesthetic and social complaints and treatment remains a challenge because of therapy resistance and high recurrence rates." | ( Bijlard, E; Busschbach, JJ; Mureau, MA; Niessen, FB; Timman, R; van Neck, JW; Verduijn, GM, 2013) |
| "Keloids are fibroproliferative extreme variants of an impaired wound healing, developing a tumour-like growth." | ( Brom, J; Freuschle, A; Hörmann, K; Schultz, JD, 2014) |
| "Keloid is an inflammatory and fibrotic disease with an unknown pathogenesis." | ( Funayama, E; Furukawa, H; Hayashi, T; Ikeda, M; Murao, N; Oyama, A; Seino, K; Yamamoto, Y, 2014) |
| "Keloids are locally exuberant dermal scars characterized by excessive fibroblast proliferation and matrix accumulation." | ( Desai, T; Martin, G; Muthusubramaniam, L; Paukshto, M; Zaitseva, T, 2014) |
| "Keloid is a proliferative disease of fibrous tissues." | ( Cen, Y; Chen, J; Liu, Y; Nicolas, C; Zhao, S, 2016) |
| "Keloids is a fibroproliferative disease." | ( Lee, YC; Sun, LM; Wang, KH, 2014) |
| "Keloids are benign fibro-proliferative skin lesions that very rarely occur on the soles." | ( Bagot, M; Battistella, M; Cavelier-Balloy, B; Duron, JB; Gorj, M; Hickman, G; Masson, V; May, P; Petit, A; Schneider, P; Vanhaecke, C; Vilmer, C, 2015) |
| "Keloids are proliferative fibrous growths resulting from excessive tissue response to skin trauma." | ( de Jong, D; Hennekam, RC; Houge, G; Peters, DJ; Shaw, AC; van Belzen, MJ; van de Kar, AL, 2014) |
| "The majority of keloids are located on the shoulders and chest." | ( de Jong, D; Hennekam, RC; Houge, G; Peters, DJ; Shaw, AC; van Belzen, MJ; van de Kar, AL, 2014) |
| "Keloids are common abnormally raised fibroproliferative lesions that can occur following even minor cutaneous trauma." | ( Lu, WS; Yao, XH; Zhang, LF; Zheng, XD, 2015) |
| "Keloids are benign dermal tumors that occur ~20 times more often in African versus Caucasian descent individuals." | ( Edwards, TL; Russell, SB; Tsosie, KS; Velez Edwards, DR; Williams, SM, 2014) |
| "Keloids are fibroproliferative dermal lesions characterized by the proliferation of fibroblasts." | ( Fang, AH; Hu, WP; Kuo, HY; Tien, LY; Wang, JJ; Wu, CS, 2015) |
| "Keloid is an excessive dermal scar occurring in response to skin injuries." | ( Chanvorachote, P; Nimmannit, U; Pongrakhananon, V; Sucontphunt, A; Unahabhokha, T; Yongsanguanchai, N, 2015) |
| "A keloid is pathological scar caused by aberrant response to skin injuries, characterized by excessive accumulation of histological extracellular matrix, and occurs in genetically susceptible individuals." | ( Long, J; Sun, Y; Wang, X; Wang, Y, 2014) |
| "A keloid is considered to be a type of benign tumor." | ( Chen, X; Liu, Y; Wang, X; Xiao, Z; Yang, D, 2014) |
| "Chest keloids are challenging to surgeons because of their high recurrence rate." | ( Chen, B; Ding, JP; Wang, LZ; Yang, MY, 2014) |
| "Keloids are one of the common refractory conditions in dermatology and aesthetic plastic surgery." | ( Cao, JP; Huan, J; Ji, J; Ji, SJ; Tian, Y; Zhang, LY; Zhou, XZ; Zhu, YQ, 2015) |
| "Keloids are benign hyper-proliferative growths of fibrous tissue where increased fibroblast activity results in abnormal collagen deposition." | ( Arbi, S; Bester, MJ; Eksteen, EC; Oberholzer, HM; Taute, H, 2015) |
| "Keloids are a pathologic condition of the reparative process, which present as excessive scar formation that involves various cells and cytokines." | ( Chang, CH; Chong, Y; Park, TH; Seo, Sw, 2015) |
| "Keloid is a protruding hypertrophic fibrous formation of the dermis." | ( Hermanns-Lê, T; Nizet, JL; Piérard, GE; Piérard-Franchimont, C, 2014) |
| "Keloid is an overgrowth of scar tissue that develops around a wound." | ( Li, G; Li, S; Song, R, 2015) |
| "Keloids are benign fibroproliferative tumors of the skin which commonly occur after injury mainly in darker skinned patients." | ( Chen, KM; Datta, I; Divine, G; Jones, LR; Ozog, D; Worsham, MJ; Young, W, 2015) |
| "Keloids are considered benign dermal fibroproliferative tumors." | ( Chen, G; Li, Q; Liang, X; Liang, Y; Liu, D, 2016) |
| "Keloids are marked by an overabundance of extracellular matrix." | ( Ahn, HM; Choi, IK; Jeon, YR; Lee, WJ; Lew, DH; Rah, DK; Yun, CO, 2016) |
| "Keloid is a fibrotic skin disease for which immune cell infiltration is a primary pathological hallmark." | ( Cai, J; Dong, P; Fan, J; Gan, C; Jiao, H; Pan, B; Xiao, R; Yan, L; Zong, X, 2015) |
| "Keloids are progressively expanding scars, mostly prevalent in individuals of African descent." | ( Frazier, R; Katdare, M; Mantel, A; Newsome, A; Thekkudan, T, 2016) |
| "Keloids are benign skin tumours and are the effect of a deregulated wound-healing process in genetically predisposed patients." | ( Boccia, L; De Felice, B; Guida, M; Nacca, M, 2015) |
| "Keloid is a type of pathological skin scar." | ( Liang, X; Long, X; Ma, L; Wang, X, 2015) |
| "Since keloids are a dysfunction of collagen fiber synthesis and organization, this study aimed to evaluate if a 1,210 nm diode laser could have effects in a new animal model of keloid scars." | ( Andrac-Meyer, L; Bertrand, B; Casanova, D; Kerfant, N; Magalon, G; Mordon, S; Philandrianos, C, 2015) |
| "Keloids are defined as benign dermal scars invading adjacent healthy tissue, characterized by aberrant fibroblast dynamics and overproduction of extracellular matrix." | ( Chan, MT; Li, Z; Wu, WK; Yu, X, 2015) |
| "Keloids are wounding-induced tumor-like human scars." | ( Benya, PD; Chiu, WC; Choi, A; Hsu, T; Kim, EW; Kulber, DA; Lee, YS; Sarkozy, H; Tuan, TL, 2016) |
| "Keloids are fibroproliferative lesions of unknown origin that are characterized by increased collagen deposition." | ( Chen, B; Jia, Y; Liu, Q; Long, X; Wang, X; Wang, Y; Yu, N, 2016) |
| "The etiology of keloids is unknown but they occur after dermal injury in genetically susceptible individuals, and they cause both physical and psychological distress for the affected individuals." | ( Andrews, JP; Macarak, E; Marttala, J; Rosenbloom, J; Uitto, J, 2016) |
| "Keloids are scars that grow beyond the boundaries of a cutaneous injury, inflammation, surgical incision, or burn." | ( Kaya, H; Polat, M; Şahin, A, 2016) |
| "Keloid is an abnormal hyperproliferative scarring process with involvement of complex genetic and triggering environmental factors." | ( Cho, S; Jin, CL; Kim, JE; Kim, M; Kim, Y; Lee, DH; Lee, MJ; Shin, MH, 2016) |
| "Keloids are common in the Asian population." | ( Long, X; Wang, X; Wang, Y; Zhang, M; Zhao, R, 2016) |
| "Keloid is the abnormal wound healing puzzled by the aggressive growth and high recurrence rate due to its unrevealed key pathogenic mechanism." | ( Cao, R; Jiao, H; Liu, Y; Lv, X; Pan, B; Sun, X; Wang, L; Xiao, R; Yan, L; Zhuang, Q, 2016) |
| "Keloid is a benign fibrous growth, which presents in scar tissue of predisposed individuals." | ( Kesh, F; Khaddam, J; Shaheen, A, 2016) |
| "Keloid is one of the most frustrating problems related to wounding healing and presents a great challenge in clinic." | ( An, G; Liang, S; Liu, Y; Sheng, C; Yao, W, 2017) |
| "Keloids are difficult to treat due to their poor response and high recurrence rate." | ( Behera, B; Kumari, R; Malathi, M; Thappa, DM, 2016) |
| "Keloids are characterized by the formation of excessive scar tissue that extends beyond the area of the initial wound." | ( Akaishi, S; Aoki, M; Dohi, T; Hyakusoku, H; Nakao, J; Ogawa, R, 2016) |
| "Keloids are fibroproliferative scars that develop as a result of a dysregulated wound healing process; however, the molecular mechanisms of keloid pathogenesis remain unclear." | ( Gao, Z; Jiang, Z; Wang, X; Wu, X; Xia, L; Yu, Q; Zhang, Y, 2016) |
| "Keloids are difficult to remove successfully and there is no universally accepted treatment." | ( Lee, NH; Roh, SG; Shin, JY; Yang, KM; Yun, SK, 2017) |
| "Keloid is conventionally treated with intra-lesional (IL) triamcinolone, which is highly operator dependent and has its own adverse effects." | ( Imran, FH; Ismail, R; Jamil, A; Nor, NM; Shah, SA, 2017) |
| "Keloids are fibrous overgrowths induced by cutaneous injury." | ( Cui, F; Pang, QY; Rang, Z; Wang, YW; Wang, ZY; Yang, G, 2016) |
| "Keloid is a benign tumor that is characterized by the hyperproliferation of dermal fibroblasts and excessive deposition of extracellular matrix (ECM) especially the collagen." | ( Jiang, RH; Kim, CD; Lee, JH; Yin, WT; Yoon, TJ; Zhou, MW; Zhu, MJ, 2017) |
| "Keloids are pathologic scars defined as dermal fibrotic tumors resulting from a disturbance of skin wound healing process." | ( Binda, D; Humbert, P; Mankhetkorn, S; Pazart, L; Rolin, G; Suttho, D, 2017) |
| "Keloids are benign fibroproliferative tumors more frequently found among African Americans." | ( Bonifacio, KM; Cruz, T; Fuentes-Duculan, J; Garcet, S; Gilleadeau, P; Krueger, JG; Kunjravia, N; Suárez-Fariñas, M; Sullivan-Whalen, M; Tirgan, MH; Wang, CQF; Xu, H, 2017) |
| "At present, keloids are classified as strongly inflammatory scars, while hypertrophic scars are considered to be mildly inflammatory scars." | ( Akaishi, S; Ogawa, R, 2016) |
| "Auricularis keloids are the keloids locating on the earlobe and helix which often caused by ear piercing, burn wound and skin injury." | ( Liu, K; Wang, PH; Wu, XL, 2016) |
| "Keloids are fibroproliferative skin disorders characterised clinically by continuous horizontal progression and post-surgical recurrence and histologically by the accumulation of collagen and fibroblast ingredients." | ( Du, Y; Huang, C; Liu, L; Ogawa, R; Wang, B; You, Z, 2017) |
| "The literature on keloids is replete with authors expressing frustration with treatment results." | ( Aluko-Olokun, B; Olaitan, AA, 2016) |
| "Keloids are abnormal overgrowth of collagen fibers, and the first-line treatment includes intralesional injection of triamcinolone acetonide (TA), which is associated with pain." | ( Burusapat, C; Usanakornkul, A, 2017) |
| "Keloids are fibroproliferative diseases characterized by the accumulation of an extracellular matrix including collagen." | ( Horinaka, M; Kawarazaki, A; Nishino, K; Numajiri, T; Sakai, T; Yasuda, S, 2017) |
| "Keloid is a pathologic fibro-proliferative disorder and is characterized by hyper-proliferation of fibroblasts and excess extracellular matrix (ECM) deposition." | ( Li, ZM; Lin, XH; Zhang, L; Zhang, QY; Zhang, Y, 2017) |
| "Keloid is a common and refractory disease characterized by abnormal fibroblast proliferation and excessive deposition of extracellular matrix components." | ( Han, G; Hu, Y; Jiao, Y; Li, S; Qi, T; Wei, G; Zhang, C, 2017) |
| "Keloid is a skin fibrosis disease that characterised by invasive growth of fibroblasts and aberrant deposition of extracellular matrix." | ( Bogari, M; Chai, G; Chen, W; Chen, X; Lin, L; Mar Aung, Z; Qu, M; Wang, X; Xin, Y; Zhang, Y; Zhu, M, 2017) |
| "Keloid is a benign fibroproliferative growths resulting from an overexuberant healing response." | ( Li, ZG, 2017) |
| "Keloids are benign dermal fibroproliferative tumors that develop as a result of several dysregulated processes." | ( Cui, F; Feng, J; Pang, Q; Rang, Z; Xue, S, 2017) |
| "Keloids are developed as fibrotic scar at the site of surgery or trauma and often enlarge beyond the original scar margins." | ( Bhusari, P; Chhabra, A; De, D; Handa, S; Kumar, M; Kumaran, S; Mittal, BR; Palarwar, K; Rathore, Y; Shukla, J; Vatsa, R, 2017) |
| "Keloids are characterized by excessive collagen deposition and growth beyond the edges of the initial injury, and cytokines may be related to their formation." | ( Carneiro, CAX; da Silva, IR; da Silva, MV; Dos Reis, MA; Furtado, PC; Peixoto, AB; Rodrigues, BR; Rodrigues, DBR; Rodrigues, V; Tiveron, LCRDC, 2017) |
| "Keloid is a disorder of fibroproliferative diseases that occurs in wounds, characterized by an exaggerated response to injury." | ( Cai, Y; Pan, M; Wang, C; Wu, W; Yang, W; Zhu, S, 2017) |
| "Keloid is one kind of benign skin disease caused by hyperplasia of fibroblasts and collagen fibrils." | ( Gong, H; Jiang, D; Jiao, Y; Qi, Y; Wang, X; Zhang, J, 2017) |
| "Keloids are abnormal fibroproliferative scars that pose a significant challenge to patients and clinicians." | ( Hahn, JM; Supp, DM, 2017) |
| "Keloids are benign cutaneous lesions, arising from proliferating fibroblasts." | ( Hoffmann, TK; Rotter, N; Scheithauer, MO; Thierauf, J; Veit, JA; Walther, M, 2017) |
| "Keloids are pathological scars characterized by excessive extracellular matrix production that are prone to form in body sites with increased skin tension." | ( Chen, WR; Cheng, CM; Harn, HI; Ho, YT; Hsu, CK; Lee, JY; Lee, YC; Lin, HH; McGrath, JA; Ogawa, R; Shieh, SJ; Tang, MJ; Wang, YK, 2018) |
| "Keloids are fibrous growths that occur as a result of abnormal response to dermal injury." | ( Ho, D; Jagdeo, J; Kraeva, E, 2017) |
| "Keloids are an exuberant response to cutaneous wound healing." | ( Glass, DA, 2017) |
| "Keloid is characterized by hyper-proliferation of fibroblasts and excess extracellular matrix (ECM) deposition." | ( Cui, S; Lu, F; Si, E; Wang, W; Yuan, Z; Zhang, X; Zhao, H, 2017) |
| "Keloids are reportedly rare at the extremes of life." | ( Adebayo, W; Ademola, SA; Iyun, AO; Michael, AI; Olawoye, OA; Oluwatosin, OM, 2017) |
| "Keloids are mysterious soft-tissue tumors that are characterized by excessive reparative processes composed of collagen-forming fibroblasts and inflammatory cells." | ( Chang, CH; Chong, Y; Kim, CW; Kim, YS; Park, TH, 2018) |
| "Keloid is a cutaneous fibroproliferative disorder." | ( Kubota, Y; Noishiki, C; Ogawa, R; Takagi, G, 2017) |
| "Keloids are characterized by abnormal fibrosis, caused by fibroblasts in response to inflammation." | ( Funayama, E; Furukawa, H; Hosono, H; Kawakubo, K; Murao, N; Ohnishi, S; Oyama, A; Sakamoto, N; Sato, C; Yamamoto, Y, 2018) |
| "Keloids are a burden for patients due to physical, aesthetic and social consequences." | ( Bijlard, E; Hovius, SER; Mureau, MAM; Niessen, FB; Timman, R; Verduijn, GM, 2018) |
| "A keloid is a fibroproliferative disorder occurring in wounds characterized by an exaggerated response to injury." | ( Gao, Z; Ma, Y; Wang, X; Yang, J, 2018) |
| "Keloids are benign dermal tumors occurring approximately 20 times more often in individuals of African descent as compared to individuals of European descent." | ( Edwards, TL; Hellwege, JN; Russell, SB; Velez Edwards, DR; Williams, SM, 2018) |
| "Keloids are benign skin tumors that develop in individuals who have a positive family history of keloid disorders." | ( De Felice, B; Garbi, C; Manfellotto, F; Nacca, M; Santoriello, M, 2018) |
| "Auricular keloids are common following ear piercing, infection, trauma, burns, or spontaneously, and they are highly resistant for treatment and are followed by severe cosmetic problems, especially for patients with bulky auricular keloids." | ( Jiang, C; Xu, Q; Yang, Y, 2019) |
| "Keloid is a fibro-proliferative skin disorder with tumor-like behavior and dependence on anaerobic glycolysis (the Warburg effect), but its exact pathogenesis is unknown." | ( Eid, N; Ito, Y; Kondo, Y; Okuno, R; Otsuki, Y; Ueda, K, 2018) |
| "Keloids are a type of abnormal scar tissue." | ( Chang, P; Guo, B; Hui, Q; Li, W; Tao, K; Zhang, Y, 2018) |
| "Keloids are skin fibroproliferative tumors characterized by locally invasive growth of fibroblasts and excessive collagen deposition." | ( Cai, L; Huang, Y; Ke, X; Wang, M; Zhang, Q; Zhao, X, 2018) |
| "Keloid is characterized by tumor-like invasive growth, high incidence, and low remission rate." | ( Guo, QG; Yao, M, 2018) |
| "Treatment of keloids is a challenge as a result of paucity of effective treatment modalities, significant side effects, and their recurrent nature." | ( Aggarwal, A; Raghukumar, S; Ravikumar, BC; Vinay, KN; Yashovardhana, DP, 2018) |
| "The pathogenesis of keloid is largely unknown." | ( Lu, CC; Lu, YY; Wang, QR; Wu, CH; Yu, WW; Zhang, CL; Zhang, L, 2018) |
| "Keloid is a common abnormal cutaneous fibroproliferative disorder." | ( Bian, L; Jin, H; Liu, Z; Lu, D; Lyu, J; Lyu, L; Zhong, L, 2018) |
| "Keloids are benign fibroproliferative tumors that extend beyond the original wound." | ( Alajmi, A; Jfri, A, 2018) |
| "Spontaneous keloids are diagnosed clinically based on the patient's history, and it is challenging to confirm since they might be triggered by minimal injury or inflammation especially if it is a single lesion." | ( Alajmi, A; Jfri, A, 2018) |
| "Keloids are defined as highly inflamed, hyperproliferative pathological scars." | ( da Cunha Colombo Tiveron, LR; da Silva, IR; da Silva, MV; Peixoto, AB; Rodrigues, DBR; Rodrigues, V, 2018) |
| "Penile and genital keloids are uncommon despite frequent surgeries in the genital area." | ( Alyami, F; Ferandez, N; Koyle, MA; Salle, JP, 2019) |
| "Genital keloids are rare and difficult to treat." | ( Alyami, F; Ferandez, N; Koyle, MA; Salle, JP, 2019) |
| "Keloids are a fibroproliferative disorder of the skin resulted from abnormal healing of injured or irritated skin and are characterized by the ability to spread beyond the original boundary of the wound." | ( Gao, Z; Liu, K; Ruan, M; Wang, X; Yang, J, 2018) |
| "Keloid is a fibrous benign tumor of the skin caused by increased fibroblast proliferation and overproduction of extracellular matrix (ECM) in the dermis." | ( Peng, W; Qiu, X; Shi, K; Yan, D; Zheng, W, 2018) |
| "Keloids are exuberant responses to cutaneous wound healing." | ( Glass, DA; Tan, A, 2019) |
| "Keloids are associated with significant morbidity related to disfigurement and/or symptoms (e." | ( Bakhshaeekia, A; Feily, A; Gianfaldoni, S; Hadibarhaghtalab, M; Lange, CS; Lotti, T; Matta, J; Pazyar, N; Ramirez-Fort, MK; Ramirez-Pacheco, LA; Rasaii, S; Seifi, V; Sohrabian, N, 2019) |
| "Keloid is a healing disorder that occurs exclusively in humans." | ( Brito, MJA; Ferreira, LM; Filho, AG; Isoldi, FC; Motoki, THC, 2019) |
| "Keloids are benign fibroproliferative skin tumors that can cause disfigurement and disability." | ( Chong, T; Costa, C; Karimpour-Fard, A; LaRanger, R; Mathes, D; Wright, WE, 2019) |
| "Keloid is characterized by excessive proliferation of scar tissue following trauma." | ( Fu, S; Huang, H; Liu, D, 2018) |
| "Keloids are a dermal fibrotic disease whose etiology remains totally unknown and for which there is no successful treatment." | ( Cao, T; Liu, T; Lv, Y; Ma, B; Pang, H; Song, H; Wang, W; Zhai, D; Zhang, H; Zhang, Y; Zhou, Z, 2019) |
| "Keloids are a common dermal pathological disorder characterized by the excessive deposition of extracellular matrix components; however, the exact pathogenesis of the disease is still not clear." | ( Guo, J; Li, X; Liu, Z; Lu, D; Lu, H; Lyu, L; Zhao, Y, 2019) |
| "Keloids are the most common pathological form of trauma healing, with features that seriously affect appearance and body function, are difficult to treat and have a high recurrence rate." | ( Lei, R; Pang, Q; Shen, Y; Wang, Y; Xu, J; Xu, M; Xu, S, 2019) |
| "Keloid is a dermal proliferative disorder characterized by the excessive proliferation and migration of keratinocytes and fibroblasts." | ( Chen, J; Liu, K; Liu, Y; Wang, X; Zhang, Z, 2019) |
| "A keloid is a type of unusually raised scar." | ( Hur, JK; Kang, S; Kim, D, 2019) |
| "Keloids are defined histopathologically as an inflammatory disorder characterized by exhibiting numerous fibroblasts, abnormal vascularization, increased number of proinflammatory immune cells as well as uncontrolled cell proliferation, and exacerbated and disorganized deposition of extracellular matrix (ECM) molecules." | ( Arciniegas, E; Carrillo, LM; Chopite, M; Ramírez, R; Rojas, H, 2019) |
| "Helical rim keloids are difficult to excise because of the complex, three-dimensional, cartilaginous structure of the helix and its thin and tightly adherent covering layer of skin." | ( Hayashi, T; Maeda, T; Murao, N; Yamamoto, Y, 2019) |
| "The aetiology of keloids is becoming clearer, but many questions remain, including about the most optimal treatment." | ( Du, Y; Huang, C; Liu, L; Ogawa, R; You, Z, 2019) |
| "Keloids are wounding-induced fibroproliferative human tumor-like skin scars of complex genetic makeup and poorly defined pathogenesis." | ( Chuong, CM; Kulber, DA; Lee, YS; Liang, YC; Tanabe, K; Tuan, TL; Widelitz, R; Wu, P, 2019) |
| "Keloids are characterized by excessive proliferation of fibroblasts and invasion of surrounding healthy skin." | ( Chang, CH; Chen, YW; Feng, CH; Hsieh, SC; Huang, SW; Lai, CS; Li, ZY; Yen, JH, 2019) |
| "Keloids are benign fibrous overgrowths that occur as a result of abnormal wound healing following cutaneous injury." | ( Chen, H; Chen, S; Gao, X; He, C; Jian, X; Qu, L; Wang, Y; Zhao, Q; Zou, Q, 2019) |
| "A keloid is a benign fibroproliferative skin tumor that results from abnormal wound healing after injury and tends to grow beyond the boundary of the original wound; the mechanism of keloid formation is still unclear." | ( Cen, Y; Chen, J; Fang, L; Li, Z; Qing, Y; Wu, J, 2019) |
| "Keloids are debilitating skin lesions that develop often as a result of minor skin lesions." | ( Modarressi, A; Petrou, IG; Pittet-Cuénod, B; Rüegg, EM, 2019) |
| "Keloids are composed of stiff tissue, which displays a fibrotic phenotype with relatively low proliferation." | ( Akaishi, S; Dohi, T; Gurtner, GC; Matsumoto, NN; Ogawa, R; Padmanabhan, J; Terashima, M; Than, PA, 2019) |
| "Keloid is characterized by overactive fibroblasts." | ( Cheng, C; Wang, S; Xu, M; Zeng, W; Zhang, D; Zhang, Y, 2019) |
| "The formation of keloid is associated with accumulation of extracellular matrix (ECM) formed mainly of collagen and fibronectin." | ( Abdu Allah, AMK; Essam, M; Farag, AGA; Hagag, MM; Mohammed, KI; Tayel, NR, 2019) |
| "Keloids are characterized by an overabundance of collagen deposition due to elevated activity and proliferation of fibroblasts, which lead to hypoxic conditions." | ( Hardiany, NS; Jusman, SWA; Ningsih, SS; Sadikin, M; Sari, DH, 2019) |
| "Keloid is characterized by benign overgrowth of dermal collagen in response to skin injury in genetically predisposed individuals." | ( Khan, HA; Paracha, MM; Sahibzada, MN, 2019) |
| "Keloids are pathologic scars, defined as fibroproliferative diseases resulting from abnormal wound responses, which grow beyond the original wound margins." | ( Chambert, J; Chatelain, B; Humbert, P; Jacquet, E; Joly, S; Lihoreau, T; Rolin, G; Sandoz, P, 2019) |
| "Keloid is a dermal tumor with high recurrence rate." | ( Chen, Y; Fu, X; Jin, Q; Niu, F; Qiao, J, 2019) |
| "Keloid is a major complication of wound healing." | ( Belie, O; Mofikoya, BO; Ugburo, AO, 2019) |
| "Keloids are hard nodules or plaques formed by excessive proliferation of connective tissue." | ( Fu, J; Li, H; Shao, Y; Sun, Y; Yang, X; Yu, W; Zhang, L; Zhang, X, 2019) |
| "Keloids are a common presenting complaint in Black Africans but remain poorly documented in these populations." | ( Akpadjan, F; Kouotou, EA; Mendouga Menye, CR; Nansseu, JR; Ndjitoyap Ndam, EC; Omona Guissana, E; Tounkara, TM; Zoung-Kanyi Bissek, AC, 2019) |
| "Keloids are considered as benign fibroproliferative skin tumors growing beyond the site of the original dermal injury." | ( Bayat, A; Khumalo, N; Tan, S, 2019) |
| "Keloid is a benign fibroblastic tumor which is most often secondary to a scar, but it can occur spontaneously in a subject with black skin." | ( Mallé, M; Touré, S, 2019) |
| "Keloids are benign skin tumors with a high recurrence rate following surgical excision." | ( Gao, Z; Huang, J; Lin, M; Liu, W; Tu, T; Wang, W; Wu, X; Zhang, W; Zhou, G, 2019) |
| "Severe keloids are currently treated with surgical resection followed by radiation." | ( Akaishi, S; Aoki, M; Dohi, T; Ogawa, R; Tsuge, T; Yamamoto, H, 2020) |
| "A keloid is defined as an overgrowth of the dense fibrous tissues that form around a wound." | ( Chu, X; Lei, R; Li, J; Li, W; Liu, F; Wang, Y; Xu, J; Zhang, S, 2019) |
| "Keloids are very resistant to treatment in dermatology and plastic surgical practice." | ( Fan, F; Hou, Z; Liu, P, 2019) |
| "Keloids are a skin disorder where the skin goes beyond the original border of the wound or trauma, resulting in functional and cosmetic deformities, displeasure, itching, pain, psychological stress, and patient dissatisfaction." | ( Ge, P; Huang, GB; Shi, CK; Zhao, YP, 2019) |
| "Keloids are caused by an imbalance between collagen matrix decomposition and production during wound repair." | ( Dong, W; Huang, J; Long, X; Wang, X; Zhang, W, 2020) |
| "Keloid is a common and frequently-occurring disease in plastic surgery, and its ugly appearance and itching symptoms bring mental and life pain to patients." | ( Hu, Z; Lu, X; Pan, B; Sun, P, 2021) |
| "Keloids are benign fibroproliferative dermal scars of unknown etiopathogenesis resulting in an exophytic protuberant growth with persistent and progressive peri-lesional expansile behavior." | ( Bayat, A; Ud-Din, S, 2020) |
| "Keloids are dermal fibroproliferative disorders that characterized by over deposition of components of the extracellular matrix." | ( Khattab, FM; Samir, MA, 2020) |
| "Keloids are benign fibro-proliferative growths occurring after skin injury or spontaneously." | ( Hegab, DS; Hewedy, ES; Mohamed, WS; Sabaa, BEI, 2022) |
| "Keloids are a major complication related to surgical wound healing and very challenging condition to treat." | ( Hietanen, KE; Huhtala, H; Järvinen, TAH; Kaartinen, IS; Tolonen, TT, 2020) |
| "Keloids are dermal fibroproliferative tumors that arise beyond the boundary of the original wound edges and invades adjacent tissue." | ( Aya, R; Ishiko, T; Katayama, Y; Kubota, H; Morimoto, N; Naitoh, M; Yamawaki, S, 2020) |
| "Keloid is a benign dermal tumor with excessive hyperplasia and deposition of collagen." | ( Huang, Y; Jiang, L; Lin, L; Liu, J; Wang, P; Wang, X; Wang, Y, 2020) |
| "Keloids are reactive or spontaneous fibroproliferative dermal tumors characterized by the exaggerated and uncontrolled accumulation of extracellular collagen." | ( Kang, Y; Kumar, R; Njauw, CN; Rajadurai, A; Rajadurai, S; Roh, MR; Tsao, H; Zheng, Z, 2020) |
| "Keloids are firm, fibrous nodules that form on an individual's skin and are associated with difficult symptoms as well as high recurrence rates." | ( Ma, J; Shen, H; Wang, Y; Zhang, Z, 2020) |
| "Keloids are induced by skin injuries such as surgeries, skin piercings, burns, and trauma." | ( Kim, YC; Park, J, 2021) |
| "Keloids are fibroproliferative skin disorders characterized by the progressive deposition of collagen." | ( Choi, YS; Han, SH; Kim, DH; Suh, HS, 2020) |
| "Keloid is a disease that is difficult to cure and has a high recurrence rate." | ( Cao, ZD; Liu, W, 2020) |
| "A keloid is characterized by red, tickling, hard, and irregular raised tissues, and it tends to outgrow its origin." | ( Guan, E; Han, Q; Huang, J; Liu, Y; Liu, Z; Long, F; Long, X; Si, L; Wang, X; Zhang, H; Zhang, M; Zhao, R; Zhao, RC, 2020) |
| "Keloid is a fibrous tissue proliferative disease in which proliferative scars grow beyond the boundary of the original wound skin." | ( Gao, YK; Jiang, H; Jie, X; Nie, B; Zhao, X, 2020) |
| "Keloids are considered as benign fibroproliferative skin tumors, and rare cases of malignancies have been reported." | ( Chen, A; Kuo, YR; Lin, SD; Ramachandran, S; Yang, CK, 2020) |
| "Management of keloid is difficult, so there is always a need for adequate and effective therapy." | ( Brar, BK; Kaushal, V; Kumar, S; Singh, A, 2020) |
| "A keloid is a type of pathological scar often caused by abnormal tissue repair after a skin injury and is more common in genetically susceptible individuals." | ( Bao, X; Feng, Y; Liu, S; Lv, W; Ren, Y; Yi, Z; Zhang, Q, 2021) |
| "Keloids are described as benign dermal fibroproliferative lesions, and vascularization may play a significant role in their pathogenesis." | ( Chen, C; Long, X; Wang, X; Wang, Y; Yu, N; Zhang, M; Zhang, W, 2021) |
| "Keloids are any unpleasant, non-compliant comorbidity affecting a major section of people around the globe who acquire it either genetically or by pathological means as a result of a skin injury." | ( Kamalasanan, K; Kumar, AS, 2021) |
| "Keloids are benign tumours caused by abnormal wound healing driven by increased expression of cytokines, including activin A." | ( de Kretser, D; Ham, S; Harrison, C; Southwick, G; Temple-Smith, P; Wallace, EM, 2021) |
| "Keloid is a representative chronic fibroproliferative condition that occurs after tissue injury." | ( Kang, H; Kim, JE; Kim, SK; Lee, DG; Lee, KJ; Lee, S; Lee, YJ; Park, H; Park, SH, 2020) |
| "Keloid is a benign fibroproliferative tumor of the skin caused by abnormal wound healing process after skin injury." | ( Chen, F; Deng, P; Feng, X; Qi, Y; Wen, H; Yang, J, 2021) |
| "Keloids are characterized by fibroblast activation and altered architecture of extracellular matrix (ECM)." | ( Gao, Z; Liu, W; Tu, T; Wang, W; Wu, X; Zhou, B, 2021) |
| "Keloids are a skin fibrotic disease that cause a number of problems for reconstructive surgeons." | ( Jiang, S; Xu, Q, 2021) |
| "Keloids are a skin fibroproliferative condition characterized by the hyperproliferation of fibroblasts and the excessive deposition of extracellular matrix (ECM) components." | ( Hu, W; Luo, X; Lv, W; Ren, Y; Wu, M; Wu, Y; Zhang, Q, 2021) |
| "Keloids are benign lesions arising from overproduction of the extracellular matrix and abnormal collagen deposition by dermal fibroblasts." | ( Bakus, AD; Garden, BC; Garden, JM; Jones, VA; Lai, O; Patel, PM, 2021) |
| "Keloids are a common condition with variable rates of treatment satisfaction." | ( Bakus, AD; Garden, BC; Garden, JM; Jones, VA; Lai, O; Patel, PM, 2021) |
| "Keloid is troublesome for patients' skin appearance and mental health, although it is a benign tumor." | ( Gao, Y; Ma, Y; Su, X; Wang, Q, 2021) |
| "Keloid is a type of skin fibroproliferative disease, characterized by excessive deposition of collagen in the extracellular matrix, myofibroblast activation and invasive growth to the surrounding normal skin tissue." | ( Luo, X; Lv, W; Ren, Y; Wu, M; Wu, Y; Yu, J; Zhang, Q, 2021) |
| "Keloid is a skin disease characterized by fibrous hyperplasia, which is often difficult to cure." | ( Li, G; Liu, L; Sun, N; Xu, L, 2021) |
| "Keloid is a kind of pathological skin scar with unclear molecular pathology." | ( Liu, N; Ma, J; Song, N; Wu, P; Wu, X; Zhang, J, 2021) |
| "Keloids are characterized by disturbance of fibroblast proliferation and apoptosis, deposition of collagen, and upregulation of dermal inflammation cells." | ( Lu, CC; Lu, YY; Qin, H; Wu, CH; Zhang, CL; Zhang, ZH, 2021) |
| "Keloids are characterized by increased deposition of fibrous tissue in the skin and subcutaneous tissue following an abnormal wound healing process." | ( Chatelain, B; Dirand, Z; Humbert, P; Isidoro, C; Lihoreau, T; Marty, P; Rolin, G; Secomandi, E; Senez, C; Tissot, M, 2021) |
| "Keloids are a type of aberrant skin scarring characterized by excessive accumulation of collagen and extracellular matrix (ECM), arising from uncontrolled wound healing responses." | ( Choi, SJ; Jeon, BH; Kim, CS; Kim, S; Lee, I; Nagar, H; Oh, SH; Piao, S, 2021) |
| "Chest keloids are a difficult sub-group of scars to treat, likely secondary to the high wound tension in the area that promotes excessive fibroblast proliferation and collagen deposition." | ( Fua, T; Miles, OJ; Paleri, S; Ramakrishnan, A; Zhou, J, 2021) |
| "Keloids are fibroproliferative disorders characterized by high recurrence rates, with few factors known to influence the same." | ( Agak, GW; Anzala, O; Nangole, FW; Ogeng'o, J; Ouyang, K; Zuriel, D, 2021) |
| "Keloids are characterized by abnormal proliferation of fibroblasts and continuous deposition of extracellular matrix (ECM) components." | ( Guo, G; Niu, T; Shi, Y; Tian, Y; Tong, Y; Wang, G, 2021) |
| "Keloids are a type of disordered scar formation which not only show heterogeneity between individuals and within the scar itself, but also share common features of hyperproliferation, abnormal extra-cellular matrix deposition and degradation, as well as altered expression of the molecular markers of wound healing." | ( Alishahedani, ME; Freeman, AF; McCann, KJ; Myles, IA; Yadav, M, 2021) |
| "Keloid is a benign tumor characterized by persistent inflammation, increased fibroblast proliferation, and abnormal deposition of collagen in the wound." | ( Chen, J; Cheng, B; Guo, J; He, QY; Lin, X; Wang, T; Xu, P; Yan, Z; Zhang, W; Zheng, W; Zhong, J; Zhou, J, 2021) |
| "Keloids are fibroproliferative dermal tumors of unknown origin that are characterized by the overabundant accumulation of extracellular matrix (ECM) components." | ( Chai, M; Gao, D; Leng, L; Li, M; Liu, B; Lv, L; Ma, J; Wang, W; Wu, Z; Zhang, S; Zhu, Y, 2021) |
| "Keloid is a benign well-demarcated overgrowth of fibrotic tissue which extends beyond the original boundaries of a defect." | ( Ali, SM; Hafiz, HSA; Mamdouh, M; Omar, GA, 2022) |
| "Keloids are essentially different from other types of scars in terms of energy metabolism." | ( Chen, Y; Fan, J; Gan, C; Jiao, H; Liu, L; Su, Z; Tian, J; Yang, Z; Zhang, T, 2022) |
| "Keloids are abnormal fibroproliferative scars with aggressive dermal growth expanding beyond the borders of the original injury." | ( Memariani, H; Memariani, M; Moravvej, H; Shahidi-Dadras, M, 2021) |
| "Keloids are fibroproliferative lesions resulting from an abnormal wound healing process due to pathological mechanisms that remain incompletely understood." | ( Anness, MC; Combs, KA; Hahn, JM; McFarland, KL; Supp, DM, 2021) |
| "Keloid is a unique refractory syndrome characterized by a proliferation disorder of the fibroblasts." | ( Li, H; Li, Y; Liu, Z; Nie, Y; Shi, L; Wang, H; Wu, H; Zheng, W, 2021) |
| "Keloid is a skin disease characterized by exaggerated scar formation, excessive fibroblast proliferation, and excessive collagen deposition." | ( Chang, KL; Hong, CH; Lee, CH; Lu, YY; Tu, HP; Wu, CH; Yang, HJ; Yang, KC, 2021) |
| "Keloids are benign fibroproliferative skin tumors." | ( Tan, M; Wu, D; Zhou, J; Zhou, Y, 2021) |
| "Keloids are common fibroproliferative tumors, and their treatment still represents a dilemma." | ( Gamea, MM; Hegab, DS; Mahmoud, WH; Serag-Eldin, YMA, 2021) |
| "Keloid is a hyperplastic pathological scar of body caused by infection, trauma, and surgery or formed spontaneously for unknown reasons." | ( Lei, JA; Qin, ZL; Zhou, Y, 2021) |
| "Keloids are disfiguring pathological scars that could cause pain and pruritus." | ( Hu, T; Liu, W; Ning, X; Xia, L; Xu, C; Yang, Y, 2021) |
| "Keloids are a benign dermal fibrotic disorder with features similar to malignant tumors." | ( Chen, J; Chen, W; Li, Z; Liu, X; Long, X; Ma, B; Meng, T; Yu, N; Zeng, Q; Zhou, Z, 2022) |
| "Keloids are focal fibrotic responses to cutaneous trauma characterized by disordered collagen, which may be associated with elevated systemic fibrocyte levels and/or wound bed chemokine expression." | ( Burdick, MD; Campbell, CA; Strieter, RM, 2021) |
| "Keloid is a fibroproliferative disorder of dermal origin, common and severe in the dark-skinned individuals." | ( Belie, MF; Belie, O; Mofikoya, BO; T Omidiji, OA; Ugburo, AO, 2021) |
| "Ear keloids are benign, fibrous proliferations due to excessive collagen synthesis and deposition." | ( Chandrashekar, BS; Madura, C; Nayak, PB; Raj, PR, 2021) |
| "Keloids are a benign fibroproliferative disease with a high tendency of recurrence." | ( Lee, JW; Seol, KH, 2021) |
| "Keloid is a fibroproliferative disorder resulting from trauma, characterized by abnormal activation of keloid fibroblasts and excessive deposition of extracellular matrix (ECM)." | ( Deng, X; Liu, J; Qi, F; Qian, L; Wang, L; Wang, Q; Wei, C; Yang, Y, 2022) |
| "Keloids are the result of aberrant tissue scarring typically occurring in injured skin, and are caused by the overgrowth of granulation tissue or collagen type III during the healing process." | ( Naik, PP, 2022) |
| "Keloids are benign skin tumors characterized by aggressive growth." | ( Huang, S; Liao, J; Liu, F; Luo, X; Shi, G; Wen, W, 2021) |
| "Keloid is an aberrant scarring process of the skin, characterized by excessive extracellular matrix synthesis and deposition." | ( Bauerschmitz, J; Baur, AS; Fröhlich, W; Kirr, M; Ostalecki, C; Pitiot, A; Plosnita, B; Rath, M; Schliep, S, 2021) |
| "Keloids are scars that extend beyond the margins of an insulting cutaneous injury." | ( Hawash, AA; Ingrasci, G; Nouri, K; Yosipovitch, G, 2021) |
| "Keloid is a type of unusually raised scar." | ( Dai, X; Lei, TC, 2021) |
| "Keloid is a benign fibro-proliferative dermal tumor formed by an abnormal scarring response to injury and characterized by excessive collagen accumulation and invasive growth." | ( Jin, M; Jin, Z; Li, C; Luo, Y; Pi, L, 2021) |
| "Keloids are a common form of pathologic wound healing and are characterized by an excessive production of extracellular matrix." | ( Jun, S; Kang, YE; Kim, CS; Kim, S; Lee, SE; Nagar, H; Oh, SH; Shin, C; Yeo, MK; Yi, S; Yi, YS, 2021) |
| "Keloid is considered as a tumor-like skin disease with multiple aetiologies including immunological factors and mechanical microenvironment." | ( Gao, Z; Liu, W; Wang, W; Wu, X; Zhou, B, 2022) |
| "Keloids are pathological wound healing responses to dermal injuries." | ( Dilogo, IH; Harsono, AD; Prasetyono, TOH, 2022) |
| "Keloids are benign fibrous tumors derived by excessive proliferation of fibroblasts and collagen synthesis after an injury, and they do not regress spontaneously." | ( Bovani, B; Clementoni, MT; Conforti, C; Crisman, G; Gennai, A; Melfa, F; Piccolo, D, 2022) |
| "Keloids are skin lesions which result from an aberration in the physiological healing process marked with overgrowth of collagen fibers." | ( Abrego, I; Hamdan, S; Lindsey, JT; Nejat, AH; Vitter, R, 2022) |
| "Keloids are laterally growing fibroproliferative skin disorders." | ( Cho, H; Dohi, T; Fukumitsu, K; Hayakawa, S; Kamegai, M; Karasawa, K; Ogawa, R; Shimizuguchi, T, 2023) |
| "The etiology of keloid is largely unknown; however, AD and keloid share inflammatory pathways characterized by T-helper cell 2 cytokines and increased dermal fibroblast activity." | ( Ahn, HJ; Jeong, SJ; Kwon, HE; Shin, MK, 2021) |
| "Keloid is a benign fibroproliferative skin tumor." | ( Lin, G; Wang, Z; Zheng, W, 2021) |
| "Keloids are intractable scar diseases and sometimes undergo hospitalization." | ( Gan, L; Kong, W; Shi, Y; Sun, Y; Tang, H; Wang, H; Xia, Z; Xiao, Y; Zhu, Z, 2022) |
| "Keloid is a benign dermal tumor characterized by abnormal proliferation and invasion of fibroblasts." | ( Huang, Z; Jiang, R; Jin, H; Li, X, 2022) |
| "Ear keloids are abnormal continuously growing healing process following cutaneous injury." | ( Al-Gendi, R; Al-Mohsen, S; Elawadi, AA; Mohamed, R; Wafa, A; Wani, S, 2022) |
| "Keloid is a skin disease marked by fibroplasia, and fibroblasts viability plays a considerable part in keloid." | ( Li, T; Liu, F; Zhan, X, 2022) |
| "Keloid is a skin fibroproliferative disease currently having no uniformly successful treatment." | ( Chen, L; Cheng, X; He, Y; Jia, C; Li, S; Su, Y; Yin, B, 2022) |
| "Keloids are disfiguring, hypertrophic scars with yet poorly understood pathomechanisms, which could lead to severe functional impairments." | ( Ankersmit, HJ; Bormann, D; Copic, D; Direder, M; Farlik, M; Golabi, B; Haslik, W; Hoetzenecker, K; Klas, K; Laggner, M; Mildner, CS; Mildner, M; Pfisterer, K; Radtke, C; Shaw, L; Tschachler, E; Vorstandlechner, V; Weiss, T, 2022) |
| "Keloids are benign fibrous growths that are caused by excessive tissue build-up." | ( Cen, Y; Deng, K; Li, W; Liu, R; Wang, R; Xiao, H; Xu, X, 2022) |
| "Keloid is commonly regarded as a benign skin tumour." | ( Gao, Z; Li, Q; Liu, W; Tu, T; Wang, W; Wu, X, 2022) |
| "Keloids are an excessive tissue response to dermal damage, characterized by uncontrolled growth and a high recurrence rate after various treatments." | ( Bi, J; Huo, R; Li, J; Li, Z; Wang, S, 2022) |
| "Keloids are benign fibroproliferative skin disorders characterized by chronic inflammation." | ( Ansai, SI; Ogawa, R; Tosa, M, 2022) |
| "Keloid is a pathological skin scar formation with complex and unclear molecular pathology mechanism." | ( Bergquist, J; Chi, X; Deng, T; Hu, W; Liu, J; Mi, J; Wang, H; Wang, Y; Yang, C; Yang, X; Zhang, C; Zhang, H; Zhu, Y, 2022) |
| "Keloids are "tumor-like" scars that grow beyond the boundary of injury." | ( Li, B; Yan, Q, 2022) |
| "Keloids are a fibrotic skin disorder caused by abnormal wound healing and featuring the activation and expansion of fibroblasts beyond the original wound margin." | ( Chan, H; Chen, TC; Hong, YK; Hsu, CK; Huang, YL; Hung, KS; Lin, YC; Liu, YT; Pai, TP; Wu, CH, 2022) |
| "Keloids are a chronic disease and cause pain, pruritus, and limitation of motion." | ( Cho, MY; Chung, KY; Roh, MR; Song, A, 2022) |
| "Keloids are benign fibroproliferative diseases with abnormally proliferated bulges beyond the edge of the skin lesions, and they are characterized by uncontrolled fibroblast proliferation and excessive extracellular matrix deposition in the dermis." | ( Chen, JY; Deng, CC; Feng, QL; Gu, JJ; Pan, HH; Xu, XY; Yang, B; Zheng, WY, 2022) |
| "Keloids are benign fibroproliferative tumors that display many cancer-like characteristics, such as progressive uncontrolled growth, lack of spontaneous regression, and extremely high rates of recurrence." | ( Fu, R; Huang, RL; Li, Q; Liu, C; Wang, X; Yan, Y; Yang, J, 2022) |
| "Keloid is a benign proliferative disease characterized by excessive deposition of extracellular matrix collagen during skin wound healing." | ( Chen, L; Liu, Y; Qi, S; Tang, J; Wang, H; Wang, P; Xie, J; Zhou, Z, 2022) |
| "BACKGROUND A keloid is a pathological scar hyperplasia that is affected by genetic and environmental factors." | ( Du, H; Guo, Y; Hao, X; Wang, J; Wen, X, 2022) |
| "Keloids are benign fibroproliferative skin tumors." | ( Li, X; Li, Y; Liu, Y; Ni, Z; Song, J; Wang, X; Zhu, F, 2022) |
| "Keloid is an abnormal fibrotic disease after cutaneous injury characterized by exaggerated scar tissue formation, which often extends beyond the boundaries of the original wound." | ( Cho, KH; Cho, ML; Choi, JW; Lee, AR; Lee, CR; Lee, JH; Lee, SY, 2022) |
| "Keloids are pathological scars extending beyond the initial wound's natural borders." | ( Andersen, PS; Schønfeldt, T, 2022) |
| "Relapse of keloids is common after corticosteroid injection in patients with oily skin." | ( Fan, H; Min, P; Peng, Y; Zhang, S; Zhang, Y, 2022) |
| "Keloids are the result of abnormal wound healing, and they differ from the normal skin of the patient in the level of blood perfusion and the degrees of inflammation, hypoxia, regeneration of vessels, and expression of sensory receptors." | ( Li, S; Long, X; Wang, X; Zhang, M, 2022) |
| "Keloids are considered disorders of fibroproliferation characterized by accumulation of collagen fibers in hypodermis and dermis, caused by inflammation, surgery, and trauma." | ( Bessar, H; Khater, EM; Khattab, FM, 2022) |
| "Keloids are a common type of pathological scar as a result of skin healing, which are extremely difficult to prevent and treat without recurrence." | ( Shao, J; Shen, Z; Sun, J; Xu, J, 2022) |
| "A keloid is a fibroproliferative disorder of unknown etiopathogenesis that requires ill-defined treatment." | ( Chen, X; Li, J; Liang, B; Pi, X; Wang, X; Yang, R; Zhang, P; Zhou, S; Zhou, X, 2022) |
| "Background: A keloid is a benign skin tumor that extends beyond the initial injury area, and its pathologic mechanism remains unclear." | ( Feng, C; Hao, Y; Liu, H; Shan, M; Song, K; Wang, Y, 2022) |
| "Keloid is a common dermis tumor, occurring repeatedly, affecting the quality of patients' life." | ( Gao, F; Li, L; Liang, ZH; Lin, SS; Lin, X; Liu, Y; Qiu, ZY; Wang, JY, 2023) |
| "Keloids are chronic dermal fibro-proliferative disorders resulting from excessive collagen deposition." | ( Ajani, AA; Akinboro, AO; Alo, AG; Olanrewaju, FO; Olasode, OA; Oripelaye, MM, 2022) |
| "Keloids are benign dermal tumors that arise from abnormal wound healing processes following skin lesions." | ( Chen, S; Hong, M; Li, X; Liu, Y; Mo, W; Shi, B; Shi, Y; Yan, T; Yu, D; Zhang, S, 2023) |
| "Keloids are skin fibroproliferative disorders, resulting from abnormal healing of deep cutaneous injuries." | ( Ioannou, E; Karalis, V; Kikionis, S; Koromvoki, M; Kyritsi, A; Panagiotopoulos, A; Polichronaki, E; Rallis, M; Roussis, V; Stratigos, A; Tagka, A; Vitsos, A, 2022) |
| "Keloids are a fibroproliferative disease characterized by unsatisfactory therapeutic effects and a high recurrence rate." | ( Chen, H; Chen, K; Chen, L; Hu, Y; Huang, D; Jin, S; Ju, M; Li, R; Liu, L; Luan, C; Wang, Z; Zhang, J; Zhou, X, 2022) |
| "Keloids are pathological scars that invade normal surrounding tissue without self-limitation, causing pain, itching, cosmetic disfigurement, etc." | ( Nurzat, Y; Xu, H; Zhang, Y; Zhu, Z, 2023) |
| "Keloid is a type of benign tumor of the skin with abnormal proliferation of fibrous tissue." | ( Hao, Y; Li, W; Liu, H; Qiu, J; Shan, M; Wang, Y, 2022) |
| "Treatment of chest keloids is challenging." | ( Ha, B; Im, S; Kim, SJ; Lee, YJ; Park, TH, 2023) |
| "Keloid is a common pathological scar, which involves the regulation of immune microenvironment." | ( Hu, Z; Wang, X, 2022) |
| "Since keloids are driven by skin injuries, the existence of keloidal dermatofibroma has been suggested to support the injury hypothesis of dermatofibroma etiology." | ( Akaishi, S; Ansai, SI; Dohi, T; Nishimoto, A; Ogawa, R, 2023) |
| "Keloids are common and have significant negative effects on quality of life." | ( Banner, L; Cohen, AJ; Gleason, L; Lazarevic, B; Malkani, K; Nikbakht, N; Talasila, S; Uitto, J, 2023) |
| "Keloids are common and have significant negative effects on quality of life." | ( Banner, L; Cohen, AJ; Gleason, L; Lazarevic, B; Malkani, K; Nikbakht, N; Talasila, S; Uitto, J, 2023) |
| "Keloids are common and have significant negative effects on quality of life." | ( Banner, L; Cohen, AJ; Gleason, L; Lazarevic, B; Malkani, K; Nikbakht, N; Talasila, S; Uitto, J, 2023) |
| "A keloid is a benign fibroproliferative skin tumor whose formation is regulated by circular RNAs (circRNAs)." | ( Cai, M; Hu, Z; Liu, L; Su, J, 2023) |
| "A keloid is a benign fibroproliferative skin tumor whose formation is regulated by circular RNAs (circRNAs)." | ( Cai, M; Hu, Z; Liu, L; Su, J, 2023) |
| "A keloid is a benign fibroproliferative skin tumor whose formation is regulated by circular RNAs (circRNAs)." | ( Cai, M; Hu, Z; Liu, L; Su, J, 2023) |
| "Keloid is a benign tumor with high recurrence rate; accordingly, complete surgical excision with adjuvant radiotherapy is one of the most effective treatments." | ( Chen, F; Chiang, CH; Huang, CJ; Huang, MY; Kuo, YR; Tang, JY, 2022) |
| "Keloid is a benign tumor with high recurrence rate; accordingly, complete surgical excision with adjuvant radiotherapy is one of the most effective treatments." | ( Chen, F; Chiang, CH; Huang, CJ; Huang, MY; Kuo, YR; Tang, JY, 2022) |
| "Keloid is a benign tumor with high recurrence rate; accordingly, complete surgical excision with adjuvant radiotherapy is one of the most effective treatments." | ( Chen, F; Chiang, CH; Huang, CJ; Huang, MY; Kuo, YR; Tang, JY, 2022) |
| "Keloids are chronic progressive dermal pseudo-tumors that can grow considerably in volume and surface area but do not invade other tissues." | ( Charvet, E; Delaleu, J; Petit, A, 2023) |
| "Keloids are chronic progressive dermal pseudo-tumors that can grow considerably in volume and surface area but do not invade other tissues." | ( Charvet, E; Delaleu, J; Petit, A, 2023) |
| "Keloid is a benign fibro-proliferative dermal tumour formed by an abnormal scarring response to injury and characterised by excessive collagen accumulation and invasive growth." | ( Hu, Z; Wang, Z; Xu, H; Yang, H; Zhu, J, 2023) |
| "Keloid is a benign fibro-proliferative dermal tumour formed by an abnormal scarring response to injury and characterised by excessive collagen accumulation and invasive growth." | ( Hu, Z; Wang, Z; Xu, H; Yang, H; Zhu, J, 2023) |
| "Keloids are fibroproliferative disorders, which seriously affect the quality of life of patients with keloids." | ( Guo, F; Hu, H; Mao, G; Zheng, J, 2022) |
| "Keloids are fibroproliferative disorders, which seriously affect the quality of life of patients with keloids." | ( Guo, F; Hu, H; Mao, G; Zheng, J, 2022) |
| "Auricular keloids are difficult to treat, and recurrent keloids are more aggressive and more likely to develop aural deformities." | ( Dong, G; Hu, J; Jin, Q; Liu, Y; Qu, C; Wang, L; Wang, M; Wu, H, 2023) |
| "The incidence of keloids is higher in the case of darker skin." | ( Abe, Y; Hashimoto, I; Ishida, S; Minami, K; Mineda, K; Nakahara, T; Sato, K; Yamashita, Y, 2023) |
| "Keloid is a pathological dermatological condition that manifests as an overgrowth scar secondary to skin trauma." | ( Qi, S; Tang, J; Wang, H; Xie, J; Zhou, Z, 2023) |
| "Keloids are defined as overrepairing products that develop after skin lesions." | ( Li, ZJ; Long, X; Qiu, ZK; Si, LB; Wang, XJ; Yu, NZ; Zhang, MZ; Zhang, WC, 2023) |
| "Keloids are considered the manifestation of a fibroproliferative disease characterized by chronic inflammation that is induced following skin injury." | ( Chao, H; He, J; Hsu, P; Liu, H; Ma, H; Tang, Q; Wu, R; Xu, S; Zeng, R; Zheng, L; Zhou, Y, 2023) |
| "Keloids are a fibroproliferative skin disorder with a high recurrence rate." | ( Chen, ZA; Gao, Z; Lin, X; Ma, QY; Wang, WB; Wu, XL; Xia, LL; Xie, CH; Yang, YT; Zhao, Q, 2023) |
| "Keloids are formed due to abnormal hyperplasia of the skin connective tissue." | ( Chen, W; Chen, X; Gan, W; Huang, J; Qin, X; Wang, X; Yang, R; Zheng, W; Zhou, S, 2023) |
| "Keloids are pathologic scars that pose a significant functional and cosmetic burden." | ( Kundu, RV; Kwan, KR; Miller, CH; Pontes, D; Poondru, S; Walsh, LA; Wu, E, 2023) |
| "Keloids are pathological scars from exuberant fibroproliferative collagen response and excessive extracellular matrix production usually extending beyond the original wound margins." | ( Martinez, F; Nguyen, A; Nguyen, BD, 2023) |
| "A keloid is a classic fibrotic skin disease characterized by excessive deposition of extracellular matrix (ECM)." | ( Bi, J; Chen, H; Li, Q; Liu, Y, 2023) |
| "Keloids are skin tumours caused by aberrant growth of dermal fibroblasts." | ( Chung, JH; Darmawan, CC; Hur, K; Kusumaningrum, N; Lee, SH; Mun, JH, 2023) |
| "Ear keloid is one of the more common forms of keloid, which may cause pain and itching, and is aesthetically unappealing." | ( Cai, XN; Ji, YC; Wang, MM, 2023) |
| "Keloid is a type of disfiguring pathological scarring unique to human skin." | ( Chen, CB; Chen, CH; Chung, WH; Lee, CC; Tsai, CH; Yeh, YC, 2023) |
| "Keloid is a type of benign fibrous proliferative tumor characterized by excessive scarring." | ( Dou, H; He, L; Jia, J; Shu, M; Yu, X; Zhu, C, 2023) |
| "Ear keloids are disfiguring disorders resistant to various treatments." | ( Ahmednaji, NM; Chen, XD; Wang, YX; Wu, XY, 2023) |
| "Usually, keloids are considered and treated as a single entity but clinical observations suggest heterogeneity in keloid morphologies with distinction of superficial/extensive and nodular entities." | ( Benssussan, A; Boccara, D; Boismal, F; Bouaziz, JD; DE LA Grange, P; Ferrero, L; Gentien, D; Henry, E; Michel, L; Mimoun, M; Serror, K; Sintes, M; Thery, M; Vianay, B, 2023) |
| "Keloid is a pathological scar formed by abnormal wound healing, characterized by the persistence of local inflammation and excessive collagen deposition, where the intensity of inflammation is positively correlated with the size of the scar formation." | ( Chen, G; Chen, L; Chi, H; Cui, Z; Du, Y; Gao, B; Song, B; Yu, Z; Zheng, Y; Zhu, Y, 2023) |
| "Keloids are an exuberant response to skin wound healing in which abundant scar tissue grows beyond the boundaries of the inciting insult." | ( Glass, DA; Knowles, A, 2023) |
| "Keloid is a heterogeneous disease featured by the excessive production of extracellular matrix." | ( Guo, C; Huang, J; Liang, L; Qiu, X; Tan, G; Wang, L; Xie, Y; Zheng, J, 2023) |
| "Keloid is a highly aggressive fibrotic disease resulting from excessive extracellular matrix deposition after dermal injury." | ( Hao, Y; Kuang, X; Liang, Z; Liu, H; Shan, M; Wang, Y; Xia, Y, 2023) |
| "Keloids are known to recur and can cause severe cosmetic, functional, and psychological impairments." | ( Datema, FR; Rothuizen, LT; Saridin, J; Timmer, FCA; van Zijl, FVWJ, 2023) |
| "Keloids are benign skin lesions that gradually invade the surrounding normal tissue, and no treatment has proven curative." | ( Han, X; Hu, SD; Ji, DS; Liu, Y; Zhao, YM, 2023) |
| "Keloids are a fibroproliferative skin disorder that develops in people of all ages." | ( Chen, H; Qian, H; Wang, C; Zhang, M, 2023) |
| "Keloids are benign skin tumors resulting from the excessive proliferation of connective tissue in wound skin." | ( Li, Z; Liang, H; Tian, B, 2023) |
| "Keloids are pathologic conditions characterized by fibroblast hyper-proliferation and excess collagen deposition." | ( Eltahlawy, S; Hamada Mohamed, B; Marzouk, WA; Mohamad, NE, 2023) |
| "Keloids are fibroproliferative disorders described by excessive growth of fibrotic tissue, which also invades adjacent areas (beyond the original wound borders)." | ( Adebayo, OE; Bordas, SPA; Chouly, F; Eftimie, R; Rolin, G; Urcun, S, 2023) |
| "Keloids are a type of fibrotic disease characterized by excessive collagen production and extracellular matrix (ECM) deposition." | ( Li, D; Wu, X; Zhang, X, 2023) |
| "Patients with keloids are often younger than 30 years old and have darker skin." | ( Bonan, P; Conforti, C; Crisman, G; Fusco, I; Piccolo, D, 2023) |
| Excerpt | Reference |
|---|
| "Here we report our method of treating recurrent keloid and hypertrophic scars." | ( Tang, YW, 1992) |
| "The optimal treatment for keloids remains undefined." | ( Lawrence, WT, 1991) |
| "The use of radiations for the treatment of keloids was the topic of debate for years." | ( Deka, AC; Deka, BC; Rao, SM; Supe, SJ; Supe, SS, 1991) |
| "Silicone gel is effective in the treatment of keloid scars." | ( Mercer, NS, 1989) |
| "Several methods for the treatment of scar keloids have been reported." | ( Ohmori, S, 1988) |
| "We report on the treatment of keloids and scars by means of topical application and injection of active substances." | ( Landes, E, 1987) |
| "Atrophic scars resulted after 1 to 8 treatments." | ( Mende, B, 1987) |
| "A report is given on the treatment of keloids and hypertrofic scars using an argon laser." | ( Hulsbergen Henning, JP; Roskam, Y; van Gemert, MJ, 1986) |
| "The results of treatment of keloids are still very disappointing." | ( Oluwasanmi, JO, 1974) |
| "In other situations, as in the treatment of keloids, physicians may wish to introduce drugs known to reduce scar formation into the biologic environment in which wound healing ensues." | ( Pollack, SV, 1982) |
| "A report is given on the treatment of keloids and hypertrophic scars using ordinary zinc tape." | ( Bartholdson, L; Hallmans, G; Söderberg, T, 1982) |
| "Morphologic changes in steroid-treated keloids were established using light and electron microscopy." | ( Boyadjiev, C; Mazgalova, J; Popchristova, E, 1995) |
| "In the treatment of keloids surgical excision followed by radiation therapy provides the highest reported control rates of 72% to 92%." | ( Anscher, M; Klumpar, DI; Murray, JC, 1994) |
| "Traditional treatment of keloids by surgery or surgery combined with other techniques has met with limited success." | ( Mincer, FR; Ship, AG; Weiss, PR; Wolkstein, W, 1993) |
| "There is no one right way to treat all keloids and hypertrophic scars." | ( Nemeth, AJ, 1993) |
| "Numerous approaches are used to treat keloids, but none is ideal for all scars and recurrence after treatment is frequent." | ( Bono, R; Rossi, G; Rusciani, L, 1993) |
| "A review of the surgical treatment of keloids with emphasis on surgery combined with nonsurgical therapies is presented." | ( Berman, B; Bieley, HC, 1996) |
| "Various lasers have been used in the treatment of keloids with great variability in the recurrence rate but in general result in similar recurrence rates as conventional surgery." | ( Berman, B; Bieley, HC, 1996) |
| "However, the results in treating keloid are variable." | ( Chang, CH; Chen, JS; Chiu, HC; Lin, LJ; Liu, CC; Wong, TW, 1996) |
| "Six patients with previously untreated keloids were studied." | ( diLeonardo, M; Kauh, YC; Mondragon, G; Rouda, S; Tan, EM; Tokarek, R; Tuan, RS, 1997) |
| "Although optimal treatment for keloids remains undefined, successful treatment can be obtained through a multimodality approach." | ( English, RS; Shenefelt, PD, 1999) |
| "As a surgical treatment for keloids, we have been using the intralesional technique which we think gives better results." | ( Egloff, DV; Gailloud-Matthieu, MC; Raffoul, W, 1999) |
| "Hence, it becomes important to treat keloids as a separate entity different from hypertrophic scars and enhancement of Fas-sensitivity could be a promising therapeutic target." | ( Chodon, T; Funayama, E; Furukawa, H; Igawa, HH; Sugihara, T, 2000) |
| "The authors treated 24 keloids of the ear, trunk, face, and genitalia with keloid core excision." | ( Baek, RM; Hong, JJ; Lee, Y; Minn, KW, 2001) |
| "HDR brachytherapy is an effective treatment for keloid scars." | ( Andrés, A; Finestres, F; Guix, B; Henríquez, I; Martínez, A; Tello, JI, 2001) |
| "The current treatment of keloids is based on surgery, medical therapy and physical treatment." | ( Baroni, A; Brongo, S; D'Andrea, F; Ferraro, G, 2002) |
| "Successful treatment of keloids is difficult." | ( Bock, O; Mrowietz, U, 2002) |
| "Ten patients with previously untreated keloidal or hypertrophic median sternotomy scars at least 6 months after surgery that were considered problematic by the patients." | ( Fitzpatrick, RE; Manuskiatti, W, 2002) |
| "We have treated 41 keloides of earlobes in 28 cases, and analyzed the factors." | ( Li, B; Liu, D; Tian, J; Zhou, C, 1999) |
| "Participants (n = 80) were treated for 80 keloid scars (59 percent female patients, 76 percent nonwhite), and 44 percent of keloids were located on earlobes." | ( Cornes, PG; Glees, JP; Moss, AL; Ragoowansi, R, 2003) |
| "Fibroblasts were cultured from nontreated earlobe keloids and burn hypertrophic scars." | ( Bay, BH; Chan, SY; Lee, ST; Phan, TT; Sun, L, 2003) |
| "We investigated whether PDL treatments induced keloid regression by decreasing growth factor-beta(1) (TGF-beta(1)) induction, thereby reducing fibroblast proliferation and collagen deposition." | ( Chang, PR; Chen, TH; Huang, HC; Jeng, SF; Kuo, YR; Wang, FS; Yang, KD, 2004) |
| "Twelve months after final PDL treatments, keloid regression ( >/= 50%) had occurred in 26/30 patients in whom erythema and surface irregularities had been reduced and pliability had been increased." | ( Chang, PR; Chen, TH; Huang, HC; Jeng, SF; Kuo, YR; Wang, FS; Yang, KD, 2004) |
| "By use of integrated methods to treat keloid, if the wound can be sutured directly, skin grafting should not be adopted." | ( Cen, Y; Cui, ZJ; Liu, XX, 2004) |
| "Biopsies from ten untreated keloids (duration of disease 3 - 30 years) and ten hypertrophic scars (duration of disease 6 - 10 months) and five normal adult skin specimens." | ( Han, CM; He, XJ; Peng, JP, 2004) |
| "As no specific effective treatment for keloid is currently available, utilization of this readily available therapeutic agent may improve treatment outcome." | ( Kronenberg, J; Orenstein, A; Talmi, YP; Wolf, M, 2005) |
| "Given the difficulty and cost of treating keloids, prevention remains the best approach." | ( Davis, LS; Lane, JE; Waller, JL, 2005) |
| "Between 1985 and 2003, we treated 109 keloid scars in 94 patients by injecting 1 to 10?mg of triamcinolone acetonide depending on the size of the lesion at four week intervals." | ( Hata, Y; Igawa, HH; Ito, O; Muneuchi, G; Onodera, M; Suzuki, S, 2006) |
| "This pilot study suggests that treatment of keloid and hypertrophic scars with intra-lesional injections of collagenase is ineffective." | ( Gault, D; Kang, N; Nduka, C; Sanders, R; Sivakumar, B, 2006) |
| "Several options are described to treat keloid scars, none of them being 100% successful." | ( Boeckx, WD; De Lorenzi, F; Lutgens, LC; Nieman, FH; Rhemrev, R; Tielemans, HJ; van der Hulst, RR, 2007) |
| "This new treatment of keloids has been shown to be effective in the majority of patients but further studies are required to confirm this benefit." | ( Bailey, JN; Clayton, WJ; Rustin, MH; Waite, AE, 2007) |
| "In all the treated keloids, the defect healed in 6-8 weeks, and no recurrence was seen while on imiquimod application; however, all keloids completely recurred within 4 weeks of stopping imiquimod." | ( Gupta, S; Khaitan, BK; Malhotra, AK; Sharma, VK, 2007) |
| "The basic treatment of keloids changed, radiotherapy was combined with the above mentioned methods because of its high recurrence rate." | ( Kelemen, O; Kollár, L, 2007) |
| "Ten of the treated keloids recurred (28." | ( Chuangsuwanich, A; Gunjittisomram, S, 2007) |
| "The primary protocol presented for the treatment of ear keloids produces durable results, with an acceptably low recurrence rate." | ( Freeman, K; Patel, MK; Rosen, DJ; Weiss, PR, 2007) |
| "The authors present their experience of treating earlobe keloids using the "sandwich" technique protocol; extralesional excision and external-beam radiotherapy are given a day before and a day after the operation." | ( Amir, A; Barnea, Y; Ben-Yosef, R; Gur, E; Leshem, D; Miller, E; Shafir, R; Stahl, S; Weiss, J; Zaretski, A, 2010) |
| "A deep core biopsy of the treated keloid performed three months following the last electrochemotherapy session showed no evidence of chronic lymphocytic leukaemia." | ( Allison, KP; Muir, T; Sainsbury, DC, 2010) |
| "In both treatment groups, keloids responded well without any major side effect." | ( Dastgheib, L; Emad, M; Ghaem, H; Mortazavi, A; Omidvari, S, 2010) |
| "A silicone gel sheet is effective for treating keloid scars following median sternotomy." | ( Akahoshi, T; Miyasaka, Y; Sakuraba, M; Suzuki, K; Takahashi, N, 2010) |
| "Successful treatment of keloids remains a challenge because this disease process has a high propensity for recurrence." | ( Gupta, M; Narang, T, 2011) |
| "We have treated keloids using a combination of surgical excision and postoperative irradiation." | ( Ishiko, T; Muneuchi, G; Naitoh, M; Suzuki, S; Yamawaki, S, 2011) |
| "The authors treated 58 chest keloid patients with surgical excision followed by intraoperative and postoperative intralesional steroid injection." | ( Chang, CH; Kim, JK; Park, TH; Seo, SW, 2011) |
| "Of course, the best treatment for keloids remains prevention." | ( Berman, B; Caperton, CV; Viera, MH, 2011) |
| "Currently, there is no gold standard treatment for keloids and hypertrophic scars (HTS)." | ( Seo, SH; Sung, HW, 2012) |
| "Patients with a history of previous treatment and keloids in the perioral region should be monitored closely for signs of recurrence and managed cautiously during treatment." | ( Chang, CH; Kim, JK; Park, TH; Seo, SW, 2012) |
| "The authors treated 1436 ear keloids in 883 patients with surgical excision followed by pressure therapy using magnets at Kangbuk Samsung Hospital over the 7." | ( Chang, CH; Kim, JK; Park, TH; Seo, SW, 2011) |
| "An established treatment for keloids is surgery and radiotherapy, using a single applied field." | ( Barber, E; Collis, CH; Eaton, DJ; Ferguson, L; Mark Simpson, G, 2012) |
| "Pulsed dye laser treatment of keloids significantly down-regulates the expression of CTGF in most cases." | ( Avram, MM; Guan, M; Huang, G; Lu, Z; Ma, Y; Yang, Q; Zhu, R, 2012) |
| "The percentage of after-treatment keloids and hypertrophic scars observed was very low (~1%) especially upon the usage of lower parameters." | ( Arunachalam, M; Bassi, A; Bonan, P; Bruscino, N; Campolmi, P; Cannarozzo, G; Lotti, T; Moretti, S; Troiano, M, 2012) |
| "There are no set guidelines for the treatment of keloids and the most common treatments are individualized and depended on the distribution, size, thickness, and consistency of lesions." | ( Accardo, M; Brongo, S; Cataldo, C; D'Andrea, F; De Francesco, F; Ferraro, GA; Grella, R; Mele, CM; Nicoletti, G, 2013) |
| "Evaluation of perioperative treatment of keloid scars with electron beam therapy or iridium 192 low dose rate brachytherapy." | ( Autret, D; Cellier, P; Fernandez, L; Jadaud, E; Krhili, S; Mahé, MA; Mesgouez-Nebout, N; Paumier, A; Poirier, AL; Rio, E; Tuchais, C; Vinchon-Petit, S; Yossi, S, 2013) |
| "To determine the main treatments used for keloids in the United States and demographics of patient visits for keloids." | ( Davis, SA; Feldman, SR; McMichael, AJ, 2013) |
| "At present, to treat or prevent keloids, new drugs are currently being designed and the pharmaceutical indications of known drugs are being expanded." | ( Huang, C; Ogawa, R, 2013) |
| "Numerous modalities have been used to treat keloids and hypertrophic scars; however, optimal treatment has not yet been established." | ( Kwon, SY; Park, K; Park, SD, 2014) |
| "In the prevention and treatment of keloids and hypertrophic scars, ointments containing heparin and onion extract are very popular." | ( Krauze-Baranowska, M; Pikuła, M; Pobłocka-Olech, L; Sznitowska, M; Trzonkowski, P; Żebrowska, ME, 2014) |
| "All patients referred for treatment of an ear keloid and undergoing subsequent surgical excision followed by immediate freezing of the postoperative wound using cryosurgery were included." | ( Boullie, MC; De Barros, A; Dehesdin, D; Joly, P; Litrowski, N, 2014) |
| "On Days 3, 6, and 9 treated keloid cells showed linear decreases in cell proliferation (BrdU), increases in Annexin V-FITC and TUNEL-positive cells, interruptions of the cell cycle and inhibition of migration in scratch-wound assays." | ( Biswas, A; Bongso, A; Choolani, M; Fong, CY; Srinivasan, A; Subramanian, A, 2014) |
| "The WJ-MSC-CM-treated keloid fibroblasts showed higher proliferation rates than their control keloid fibroblasts with no significant change in apoptosis rate or migration ability." | ( Al-Shehab, M; Amini-Nik, S; Arno, AI; Belo, C; Blit, PH; Herer, E; Jeschke, MG, 2014) |
| "Although there was a report about treating keloid with topical captopril, the further investigation about captopril affecting keloid has not been performed so far." | ( Cen, Y; Chen, J; Liu, Y; Nicolas, C; Zhao, S, 2016) |
| "A variety of therapeutic procedures for treating keloids have been previously reported, with varying success and recurrence rates." | ( Babic, D; Dunda, S; Eppstein, RJ; Har-Shai, Y; Pallua, N; Stromps, JP, 2014) |
| "Finally, additional treatment of keloid scars previously unresponsive to IL cryotherapy is predisposed to a high recurrence rate." | ( Bulstra, AE; Niessen, FB; van Leeuwen, MC; van Leeuwen, PA, 2014) |
| "Cryosurgery is a safe and effective treatment of keloids." | ( Abdel-Meguid, AM; Awad, SM; Refaiy, AE; Sayed, DS; Weshahy, AH, 2015) |
| "Intralesional cryotherapy is a novel treatment for keloid scars in which the scar is frozen from inside." | ( Bulstra, AJ; Galindo-Garre, F; Molier, J; Niessen, FB; van der Wal, MBA; van Leeuwen, MCE; van Leeuwen, PAM; van Zuijlen, PPM, 2015) |
| "Intralesional cryotherapy for the treatment of keloid scars shows favorable results in terms of reduction of volume and complaints of pain and pruritus." | ( Bulstra, AJ; Galindo-Garre, F; Molier, J; Niessen, FB; van der Wal, MBA; van Leeuwen, MCE; van Leeuwen, PAM; van Zuijlen, PPM, 2015) |
| "Glucocorticoids (GCs) are first-line treatment for keloid disease (KD) but are limited by high incidence of resistance, recurrence and undesirable side-effects." | ( Bayat, A; Matthews, LC; McGrouther, DA; Ray, DW; Rutkowski, D; Syed, F; Watson, RE, 2015) |
| "The untreated cultured keloid fibroblasts served as controls." | ( Avram, MM; Guan, M; Huang, G; Lu, Z; Ma, Y; Yang, Q; Yue, B; Zhu, R, 2015) |
| "Radiation therapy is considered to be a treatment for keloid scarring; however, radioresistance has been shown to be a serious impediment to treatment efficacy." | ( Long, F; Long, X; Si, L; Wang, X; Yang, B; Zhang, F, 2016) |
| "None of therapeutic options for the treatment of keloids has been found completely effective and satisfactory." | ( Abdel Hay, RM; El Hawary, MS; Nour-Edin, F; Sayed, K; Weshay, AH, 2015) |
| "The authors successfully treated pediatric keloids selecting proper regimen according to anatomic locations." | ( Chang, CH; Park, TH, 2015) |
| "The 17-AAG-treated keloid fibroblasts showed significantly decreased proliferation, promotion of apoptosis, and decreased expression of Akt." | ( Lee, MH; Lee, WJ; Lew, DH; Park, JC; Rah, DK; Yun, IS, 2015) |
| "Effective treatment of keloid scars is important because patients are often confronted with major cosmetic, psychological, and social consequences." | ( Colla, C; Erends, M; Piatkowski de Grzymala, AA; Van den Kerckhove, E; van der Aa, T; van der Hulst, RR; Verhiel, SH, 2015) |
| "In addition, in 17-AAG-treated keloid spheroids, the collagen deposition and expression of major extracellular matrix proteins were investigated by means of Masson trichrome staining and immunohistochemistry." | ( Ahn, HM; Kim, YO; Lee, JH; Lee, WJ; Lew, DH; Song, SY; Yun, CO, 2015) |
| "Currently, the treatment of keloids remains a challenge for high recurrence rates." | ( Boccia, L; De Felice, B; Guida, M; Nacca, M, 2015) |
| "PDL and long-pulsed Nd:YAG laser treatments for keloid and hypertrophic scar provide significant improvement with insignificant difference between both modalities." | ( Al-Mohamady, Ael-S; Ibrahim, SM; Muhammad, MM, 2016) |
| "Twenty-one patients with 61 untreated keloids were enrolled into this study." | ( Chen, B; Jia, Y; Liu, Q; Long, X; Wang, X; Wang, Y; Yu, N, 2016) |
| "Five patients underwent treatment; two had keloids involving the superior helix of the ear (average area, 2." | ( Bastidas, N; Kasabian, AK; Nguyen, KT; Shikowitz, L, 2016) |
| "Sorafenib is a promising agent for the treatment of keloids and hypertrophic scars." | ( Chen, YL; Ding, X; Gao, Z; Gu, T; Liu, W; Qu, M; Wang, W; Wu, X; Xu, L; Zhang, W, 2016) |
| "It is difficult to find an ideal treatment for keloids in this area due to the limit of local soft tissues and higher recurrence rate." | ( Long, X; Wang, X; Wang, Y; Zhang, M; Zhao, R, 2016) |
| "The color of 33 untreated keloids from 30 patients was measured with a narrow-band reflectance colorimeter." | ( Akaishi, S; Aoki, M; Dohi, T; Hyakusoku, H; Nakao, J; Ogawa, R, 2016) |
| "Hence, it may be used as an alternative treatment for keloid particularly in patients with low pain threshold, needle phobia and those who prefers home-based treatment." | ( Imran, FH; Ismail, R; Jamil, A; Nor, NM; Shah, SA, 2017) |
| "After treatment, the mean keloid VSS score was decreased on both sides (4." | ( Chun, JY; Lee, JH; Park, JH, 2017) |
| "Impact statement Effective treatment of keloid that is a commonly recurrent dermatosis is very difficult, even after standard treatment." | ( Alencar, AP; da Silva, BB; Filho, LL; Soares-Lopes, IM; Soares-Lopes, LR, 2017) |
| "The radioactive patch treatment of keloids is noninvasive, painless and safe with prolonged outcome." | ( Bhusari, P; Chhabra, A; De, D; Handa, S; Kumar, M; Kumaran, S; Mittal, BR; Palarwar, K; Rathore, Y; Shukla, J; Vatsa, R, 2017) |
| "Patient cohorts from 3 centers treated with keloid excision followed by 2 × 9 Gy, 3 × 6 Gy, or 2 × 6 Gy high-dose-rate brachytherapy were retrospectively compared regarding recurrence (after at least 12 months' follow-up) and complications (after at least 1 month's follow-up), using logistic regression analyses." | ( Bijlard, E; Dehnad, H; Harmeling, JX; Meijer, OWM; Mureau, MAM; Niessen, FB; Verduijn, GM, 2018) |
| "Effective treatment of keloids is challenging because the recurrence rate after surgical excision is high." | ( Gold, DA; Jacobsen, G; Jones, LR; Ozog, DM; Sheinin, R, 2018) |
| "After conventional treatments, keloid scars show varying degrees of recurrence." | ( Ezzedine, K; Hermeziu, O; Hersant, B; Meningaud, JP; Picard, F; Rodriguez, AM; SidAhmed-Mezi, M, 2018) |
| "Previous treatments for keloids include surgery, drugs, lasers and so on." | ( Guo, QG; Yao, M, 2018) |
| "First-line treatment of formed keloids involves topical or intralesional steroids." | ( Bakhshaeekia, A; Feily, A; Gianfaldoni, S; Hadibarhaghtalab, M; Lange, CS; Lotti, T; Matta, J; Pazyar, N; Ramirez-Fort, MK; Ramirez-Pacheco, LA; Rasaii, S; Seifi, V; Sohrabian, N, 2019) |
| "The OSI-027 treatment of keloid keratinocytes showed more effectively inhibited cell proliferation and migration compared to the mTORC1 inhibitor, rapamycin." | ( Chen, J; Liu, K; Liu, Y; Wang, X; Zhang, Z, 2019) |
| "One of the first-line options to treat keloid scars is corticosteroid injection after excision of the existing scar." | ( Chua, SC; Gidaszewski, B; Khajehei, M, 2019) |
| "Current understanding of steroid treatments for keloids is in regards to modulation of inflammation, proliferation, and apoptosis, with no in vivo study on the latter." | ( Chen, AD; Chen, RF; Huang, YT; Kuo, YR; Lai, CS; Li, YT; Lin, SD, 2019) |
| "However, the clinical treatment of keloid, such as drug injection treatment, surgical resection, cryotherapy, laser treatment and other therapeutic effects are poor." | ( Hu, Z; Lu, X; Pan, B; Sun, P, 2021) |
| "Stiffness in post-treated keloids and normal skins was significantly different (P < 0." | ( Cheng, S; Guo, RQ; Huang, SY; Qiu, L; Wang, LY; Xiang, X, 2020) |
| "We used microneedles to treat keloid because this method has the feasibility of self-administration without pain." | ( Kim, YC; Park, J, 2021) |
| "Concerning the treatment of keloids and hypertrophic scars, even though verapamil was safer than TAC, TAC worked faster than verapamil." | ( Deng, Z; Liu, L; Liu, R; Yang, B; Zhao, X, 2020) |
| "IL verapamil is effective in the treatment of keloids which is possibly attributed to suppression of MMP9 and VEGF." | ( Abou-Taleb, DAE; Badary, DM, 2021) |
| "After treatment, the mean keloid VSS of the injection side became 2." | ( Abd El-Dayem, DH; Elsaie, ML; Hanafy, NS; Nada, HA, 2021) |
| "A total of 59 patients with 110 untreated keloids on the anterior chest were enrolled in this study." | ( Chen, C; Long, X; Wang, X; Wang, Y; Yu, N; Zhang, M; Zhang, W, 2021) |
| "All patients treated for keloids at the authors' institution were included." | ( Breton, P; Daurade, M; Ibrahim, B; Lorchel, F; Rouard, N; Sigaux, N, 2020) |
| "Cryotherapy is used to treat keloid scars; however, the molecular and pathological mechanisms are not clearly understood." | ( Kim, J; Kim, SM; Lee, JH; Lee, WJ; Lee, YI; Song, SY, 2020) |
| "There are numerous strategies to treat keloid." | ( Kamalasanan, K; Kumar, AS, 2021) |
| "Autophagy induction by rapamycin treatment in keloid fibroblasts effectively suppressed expression levels of Notch1 and NLRP3 inflammasome proteins." | ( Kang, H; Kim, JE; Kim, SK; Lee, DG; Lee, KJ; Lee, S; Lee, YJ; Park, H; Park, SH, 2020) |
| "Recently, successful treatment of keloids has been reported using the Nd:YAG laser in conjunction with 5-fluorouracil and intralesional corticosteroids." | ( Bakus, AD; Garden, BC; Garden, JM; Jones, VA; Lai, O; Patel, PM, 2021) |
| "The successful treatment of keloids is a great challenge in the plastic surgery field." | ( Chen, ZY; Liu, XM; Wang, XM; Wang, Y, 2021) |
| "At present, the consensus on the best treatment for keloids is the combination of clinical and surgical therapies, if necessary, associated with adjuvant radiotherapy like brachytherapy." | ( Wang, T; Wen, P; Wu, C; Yu, Y; Zhou, Y, 2021) |
| "There are few means to treat large keloid scars, as exeresis-even if partial-impedes direct closure without tension in the absence of a flap or a skin graft." | ( Azoulay, L; Boccara, D; Chaouat, M; Chatelain, S; Mimoun, M; Serror, K, 2021) |
| "A retrospective study of patients treated for keloid scars by using the new therapeutic protocol." | ( Azoulay, L; Boccara, D; Chaouat, M; Chatelain, S; Mimoun, M; Serror, K, 2021) |
| "Although clinical case studies for the treatment of keloid or hypertrophic scars are limited, it is necessary and helpful to understand the effectiveness of corticosteroid combined with botulinum toxin type A in the treatment of keloid or hypertrophic scars." | ( Liu, XG; Zhang, D, 2021) |
| "Despite numerous existing treatments for keloids, the responses in the clinic have been disappointing, due to either low efficacy or side effects." | ( Chen, LM; Feng, HC; Friedrich, RE; Fu, LL; Gosau, M; Nada, OA; Smeets, R; Yan, M, 2021) |
| "Kynurenine shows promise as a topical treatment for keloids and hypertrophic scars." | ( Arnold, D; Berman, B; Fischer, DL; Gade, A; Han, H; Lawson, A; Nestor, MS, 2021) |
| "Coupled with few effective treatments in keloid at present, we have focused on the immunological mechanisms of keloids with an aim to unravel some new therapeutic approaches in the future." | ( Fu, S; Ogawa, R; Wu, H; Yu, Y; Zhang, Q, 2021) |
| "Of the 40 patients for a total of 41 treated keloids in the first group, 85." | ( Bovani, B; Clementoni, MT; Conforti, C; Crisman, G; Gennai, A; Melfa, F; Piccolo, D, 2022) |
| "Cryosurgery, the most common treatment for keloids, causes skin traumas." | ( Ioannou, E; Karalis, V; Kikionis, S; Koromvoki, M; Kyritsi, A; Panagiotopoulos, A; Polichronaki, E; Rallis, M; Roussis, V; Stratigos, A; Tagka, A; Vitsos, A, 2022) |
| "Six patients with recurred keloid were treated with keloid surgery and radiotherapy for the second time." | ( Hao, Y; Li, W; Liu, H; Qiu, J; Shan, M; Wang, Y, 2022) |
| "Many methods have been used for the treatment of keloids and hypertrophic scars, there is no standardized method so far." | ( Li, X; Zhang, W, 2023) |
| "Concerning the treatment of keloids and hypertrophic scars, TAC was more effective than verapamil for improving vascularity; TAC was superior to verapamil in improving height within 9 weeks of treatment; TAC produced superior result for improving pliability within 18 weeks of treatment, whereas verapamil produced superior result between 18 and 24 weeks of treatment." | ( Li, X; Zhang, W, 2023) |
| "A standardized and sequential treatment plan for keloids with different morphology and anatomical locations can achieve remodeling of the auricular morphology and maintain long-term results." | ( Dong, G; Hu, J; Jin, Q; Liu, Y; Qu, C; Wang, L; Wang, M; Wu, H, 2023) |
| "Standard treatment for keloids includes combination intralesional therapy with triamcinolone and fluorouracil." | ( Frazier, WT; Proddutur, S; Swope, K, 2023) |
| "Intralesional treatments for keloid and hypertrophic scars may be the most reliable treatment option to improve pathologic scars, while laser treatment may have specific benefits for Fitzpatrick skin types I-III over types IV-VI." | ( Alam, M; Anvery, N; Asadbeigi, SN; Christensen, RE; Dirr, MA; Hisham, FI; Ibrahim, SA; Jain-Poster, K; Kang, BY; Kim, K; Merkel, EA; Poon, E; Reynolds, KA; Worley, B, 2023) |
| "In addition, dasatinib-treated keloid fibroblasts conditioned medium reduced procollagen and p16 expression in cultured keloid fibroblasts." | ( Chung, JH; Darmawan, CC; Hur, K; Kusumaningrum, N; Lee, SH; Mun, JH, 2023) |
| "(2) After drug injection treatment, the keloid began to shrink, some of the keloids disappeared." | ( Luo, QF, 2023) |
| "First-line treatment of keloids consists of intralesional needle injections with corticosteroids, but generally entails multiple painful sessions, resulting in variable clinical outcomes." | ( Bik, L; Elmzoon, I; Prens, EP; van Doorn, MBA; Wolkerstorfer, A, 2023) |
| "Among 56 treated keloids, 89." | ( Alessandro, G; Bruno, B; Claudio, C; Daniele, B; Domenico, P; Fabrizio, M; Giuliana, C; Matteo, TC, 2023) |
| "Dermatologists may want to consider treating keloids that cover a large area with systemic dupilumab, a therapy with an established, reassuring safety profile." | ( Cobos, G; LaChance, AH; Lee, MS; Mazori, DR; Merola, JF; Min, MS; Vleugels, RA, 2023) |