Glaucoma, Angle Closure

Synonym
Glaucoma, Narrow-Angle
Glaucoma, Uncompensated
Glaucoma, Uncompensative
Glaucoma, Angle Closure
Glaucoma, Closed-Angle

Excerpt	Reference
"The angle closure glaucomas are defined by iridotrabecular contact, trabecular dysfunction, and elevated intraocular pressure (IOP)."	( Liebmann, JM; Ritch, R, 2002)
"Acute angle closure glaucoma is an ocular emergency that is treatable with prompt and appropriate intervention."	( Berkoff, DJ; Sanchez, LD, 2005)
"Primary angle closure glaucoma is a common cause of visual loss worldwide."	( Huang, D; Radhakrishnan, S; Smith, SD, 2005)
"Acute angle closure glaucoma is a rare complication of general anesthesia."	( Devys, JM; Gabison, E; Gayat, E, 2011)
"Acute angle closure glaucoma is a well-known side effect of topiramate, but is rarely seen in children."	( Benegas, N; Joos, KM; Kuchtey, RW; Rapoport, Y, 2014)
"Primary angle closure glaucoma is a major cause of visual morbidity in Asia, which hosts 80% of the worldwide cases."	( Bhattacharyya, M; Singh, A; Singh, K, 2021)
"Secondary angle closure glaucoma is a very heterogeneous subtype of glaucoma with a variety of possible causes leading to a blockade of the regular aqueous humour flow or outflow."	( Lübke, J; Nüßle, S, 2021)
"Primary angle closure glaucoma is the main type of glaucoma in Asia."	( Wu, LL; Yan, YJ, 2022)
"Acute primary angle closure glaucoma is a potentially blinding ophthalmic emergency requiring prompt treatment to lower the elevated intraocular pressure in humans and dogs."	( Bannasch, DL; Casanova, MI; Daley, NL; Gomes, FE; Good, KL; Kim, S; Kuchtey, J; Leonard, BC; Martins, BDC; Murphy, CJ; Park, S; Thomasy, SM, 2022)

Excerpt	Reference
"Acute angle closure glaucoma has been observed with the use of topiramate."	( Asconapé, JJ, 2002)
"Eyes with primary angle closure glaucoma have a thinner iris with a shorter trabecular iris angle, angle opening distance, and trabecular ciliary process distance."	( Dada, T; Gupta, R; Lakshminarayan, P; Pandey, RM; Sihota, R, 2005)

Excerpt	Reference
"The treatment of acute angle closure glaucoma has been influenced by the development of the YAG laser and its ability to perform iridotomies as an outpatient procedure."	( Benjamin, L; Buckley, SA; Burdon, M; Edelsten, C; Moorman, C; Reeves, B; Wheatcroft, S, 1994)
"A therapy-resistant angle closure glaucoma following displacement of the lens-iris diaphragm due to massive choroidal and subretinal hemorrhages has rarely been reported."	( Hesse, L; Poller, S, 1997)
"We describe a case of bilateral acute angle closure glaucoma associated with oral topiramate therapy."	( Almog, Y; Assia, E; Nemet, A; Nesher, R, 2002)
"Acute angle closure glaucoma is an ocular emergency that is treatable with prompt and appropriate intervention."	( Berkoff, DJ; Sanchez, LD, 2005)
"A diagnosis of acute angle closure glaucoma was made and she was treated with no complications."	( Robinson, S; Sarkies, N; Titchener, AG; Tse, DM, 2009)
"A case of severe acute bilateral angle closure glaucoma with visual blurring after oral topiramate therapy."	( Caglar, C; Ceyhan, D; Yasar, T, 2012)
"BACKGROUND Drug-induced acute angle closure glaucoma is an uncommon ocular emergency that may follow the administration of certain topical and systemic medications."	( Alarfaj, MA; Almater, AI, 2021)
"Acute primary angle closure glaucoma is a potentially blinding ophthalmic emergency requiring prompt treatment to lower the elevated intraocular pressure in humans and dogs."	( Bannasch, DL; Casanova, MI; Daley, NL; Gomes, FE; Good, KL; Kim, S; Kuchtey, J; Leonard, BC; Martins, BDC; Murphy, CJ; Park, S; Thomasy, SM, 2022)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	80 (5.83)	23.3326
1990's	252 (18.35)	12.5806
2000's	361 (26.29)	18.1394
2010's	497 (36.20)	28.8240
2020's	183 (13.33)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	2	0
carbon monoxide	low	1	0
carnitine	low	1	0
citric acid, anhydrous	low	1	0
bupropion	low	2	0
cytosine	low	1	0
glycerol	low	4	0
dalteparin	low	1	0
histamine	low	1	0
nitrates	medium	2	1
thymine	low	1	0
uric acid	low	2	0
urea	low	7	0
xanthine	low	1	0
n-methyl-3,4-methylenedioxyamphetamine	low	2	0
acetaminophen	low	3	0
acetazolamide	medium	46	5
albuterol	low	9	0
amitriptyline	low	1	0
apraclonidine	medium	7	3
aspirin	medium	3	1
azathioprine	low	1	0
betaxolol	low	2	0
bupivacaine	low	1	0
carbamazepine	low	2	0
carteolol	medium	1	1
chloroquine	low	1	0
chlorpromazine	low	2	0
chlorthalidone	low	1	0
citalopram	low	4	0
clomipramine	low	1	0
clonidine	medium	8	4
cyclopentolate	low	5	0
diclofenac	low	1	0
dichlorphenamide	medium	2	1
dicyclomine	low	1	0
valproic acid	low	1	0
donepezil	low	1	0
erythrosine	low	1	0
felbamate	low	1	0
fenfluramine	low	1	0
fentanyl	low	2	0
fexofenadine	low	1	0
flavoxate	low	1	0
fluorouracil	medium	22	9
furosemide	low	2	0
gabapentin	low	1	0
gentamicin	low	1	0
guaifenesin	low	1	0
hydrochlorothiazide	low	3	0
p-hydroxyamphetamine	low	1	0
ibuprofen	low	1	0
lidocaine	medium	6	3
imipramine	low	3	0
indapamide	low	1	0
indomethacin	medium	1	1
ioxaglate	low	1	0
2-propanol	medium	779	59
isoproterenol	low	1	0
ketamine	low	1	0
lorazepam	low	1	0
losartan	low	1	0
memantine	low	1	0
mepivacaine	low	1	0
methazolamide	low	2	0
methylphenidate	low	1	0
mianserin	low	2	0
mirtazapine	low	1	0
naphazoline	low	1	0
nefopam	low	1	0
oxybutynin	low	2	0
palmidrol	medium	1	1
pheniramine	low	1	0
promethazine	low	1	0
propiverine	medium	1	1
propofol	low	1	0
propranolol	low	1	0
pyrimethamine	low	1	0
sumatriptan	low	3	0
terbutaline	low	1	0
terfenadine	low	1	0
ticlopidine	medium	1	1
trazodone	low	1	0
tropicamide	medium	12	1
xylazine	low	1	0
zonisamide	low	1	0
mitomycin	medium	57	14
prednisolone	medium	12	3
dibenzylchlorethamine	low	1	0
prednisolone acetate	medium	4	2
prednisone	low	7	0
pilocarpine	medium	67	9
isoflurophate	low	1	0
alanine	low	1	0
demecarium	low	1	0
physostigmine	low	1	0
phenylephrine	low	16	0
tyrosine	low	1	0
colchicine	low	1	0
mannitol	medium	13	1
valine	low	1	0
arginine	low	1	0
perflutren	low	2	0
triamcinolone acetonide	medium	4	1
methylprednisolone	low	5	0
isosorbide dinitrate	low	1	0
pseudoephedrine	low	1	0
quinoxalines	medium	7	4
cyclohexanol	low	3	0
thiophenes	medium	10	1
tecnazene	low	2	0
isoxazoles	low	1	0
ephedrine	low	2	0
perfluorodecalin	low	1	0
betamethasone	low	1	0
phenylpropanolamine	low	2	0
echothiophate iodide	low	1	0
methamphetamine	low	1	0
malondialdehyde	low	2	0
fluorescein	low	2	0
floxacillin	low	1	0
iridium	low	1	0
neodymium	medium	2	1
argon	low	10	0
erbium	low	1	0
gadolinium	low	1	0
yttrium	low	2	0
trolamine salicylate	low	2	0
isosorbide-5-mononitrate	low	1	0
iodine	low	1	0
du-21220	low	2	0
glutamic acid	low	4	0
timolol	medium	45	15
tramadol	low	1	0
paclitaxel	low	1	0
dobutamine	low	1	0
levobunolol	low	2	0
propiconazole	medium	7	1
paroxetine	low	7	0
colforsin	medium	1	1
fomesafen	low	1	0
clopidogrel	medium	1	1
aripiprazole	low	1	0
duloxetine hydrochloride	low	2	0
zolmitriptan	low	1	0
adenosine	low	1	0
venlafaxine hydrochloride	low	4	0
oseltamivir	low	1	0
2-(n-cyclohexylamino)ethanesulfonic acid	low	2	0
triazoles	low	1	0
brinzolamide	low	1	0
oxazolidin-2-one	low	1	0
clarithromycin	low	1	0
homocysteine	low	1	0
glucuronic acid	low	1	0
anecortave acetate	low	1	0
peroxynitrous acid	low	1	0
methotrexate	low	1	0
tamsulosin	low	1	0
proline	low	1	0
mn(iii) 5,10,15,20-tetrakis(n-methylpyridinium-2-yl)porphyrin	low	1	0
atropine	low	16	0
cortisone	low	2	0
3-nitrotyrosine	low	1	0
homoharringtonine	low	1	0
trimethoprim, sulfamethoxazole drug combination	low	2	0
carboplatin	low	1	0
fibrin	low	3	0
rocuronium	low	2	0
cocaine	low	3	0
D-fructopyranose	low	64	0
tamoxifen	low	1	0
nitrogen dioxide	low	1	0
dapiprazole	low	1	0
dinoprostone	low	2	0
11-cis-retinal	low	1	0
rutin	medium	1	1
amphotericin b	low	1	0
humulene	low	1	0
travoprost	medium	7	5
isotretinoin	low	1	0
4-hydroxy-2-nonenal	low	1	0
codeine	low	1	0
phenylephrine hydrochloride	low	1	0
dorzolamide	medium	9	1
topiramate	low	67	0
bimatoprost	medium	5	3
cloprostenol	medium	10	7
latanoprost	medium	31	13
fluvoxamine	low	1	0
8-oxo-7,8-dihydrodeoxyguanine	low	1	0
aluminum	low	2	0
bismuth	low	1	0
dextromethorphan	low	1	0
puerarin	medium	1	1
pregabalin	low	1	0
tiotropium bromide	low	1	0
s 1743	low	1	0
ticagrelor	low	1	0
brimonidine tartrate	medium	13	6
losartan potassium	low	1	0
indocyanine green	medium	2	1
jaw	low	1	0
atrial natriuretic factor	low	1	0
endothelin-1	low	2	0
sodium ethylxanthate	low	1	0
tolterodine tartrate	low	1	0
piperidines	low	1	0
interleukin-8	low	3	0
methylcellulose	low	1	0
chondroitin	low	1	0
ascorbic acid	low	1	0
warfarin	medium	5	1
dorzolamide-timolol combination	low	1	0
transforming growth factor beta	low	4	0
erdafitinib	low	1	0
transforming growth factor alpha	low	1	0
cyclosporine	low	2	0
chondroitin sulfates	low	1	0
exudates	low	5	0
levoleucovorin	low	1	0
guanine	low	1	0
hypoxanthine	low	1	0
inosine	low	1	0
olanzapine	low	3	0
sildenafil citrate	low	2	0
trypan blue	low	2	0
8-hydroxy-2'-deoxyguanosine	low	1	0
eye	low	78	0

Protein Targets (1,468)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, Retinaldehyde-binding protein 1	0	0	1	1
Chain A, Retinaldehyde-binding protein 1	0	0	1	1
hypoxia-inducible factor 1 alpha subunit	17	0	0	17
RAR-related orphan receptor gamma	46	0	0	46
GLI family zinc finger 3	58	0	0	58
AR protein	75	0	0	75
aldehyde dehydrogenase 1 family, member A1	28	0	0	28
retinoic acid nuclear receptor alpha variant 1	52	0	0	52
retinoid X nuclear receptor alpha	42	0	0	42
estrogen nuclear receptor alpha	81	0	0	81
peroxisome proliferator-activated receptor delta	29	0	0	29
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	35	0	0	35
activating transcription factor 6	20	0	0	20
v-jun sarcoma virus 17 oncogene homolog (avian)	32	0	0	32
Histone H2A.x	23	0	0	23
thyroid hormone receptor beta isoform a	16	0	0	16
heat shock protein beta-1	16	0	0	16
nuclear factor erythroid 2-related factor 2 isoform 1	50	0	0	50
lamin isoform A-delta10	54	0	0	54
Voltage-dependent calcium channel gamma-2 subunit	23	0	0	23
Glutamate receptor 2	23	2	1	26
Chain A, Putative fructose-1,6-bisphosphate aldolase	8	0	0	8
Chain A, JmjC domain-containing histone demethylation protein 3A	5	0	0	5
phosphopantetheinyl transferase	21	0	0	21
bromodomain adjacent to zinc finger domain 2B	10	0	0	10
euchromatic histone-lysine N-methyltransferase 2	59	0	0	59
pyruvate kinase PKM isoform a	1	0	0	1
geminin	57	0	0	57
Glycoprotein hormones alpha chain	1	0	0	1
Guanine nucleotide-binding protein G	4	0	0	4
Tubulin--tyrosine ligase	0	2	0	2
Microtubule-associated protein tau	24	0	0	24
vitamin D3 receptor isoform VDRA	20	0	0	20
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain B, Avidin	0	0	1	1
ATAD5 protein, partial	21	0	0	21
GLS protein	28	0	0	28
Smad3	12	0	0	12
thyroid stimulating hormone receptor	24	0	0	24
nuclear receptor subfamily 1, group I, member 3	42	0	0	42
progesterone receptor	33	0	0	33
EWS/FLI fusion protein	33	0	0	33
estrogen-related nuclear receptor alpha	61	0	0	61
peroxisome proliferator activated receptor gamma	37	0	0	37
aryl hydrocarbon receptor	21	0	0	21
chromobox protein homolog 1	36	0	0	36
thyroid hormone receptor beta isoform 2	47	0	0	47
peripheral myelin protein 22	34	0	0	34
cytochrome P450 3A4 isoform 1	22	0	0	22
Gamma-aminobutyric acid receptor subunit pi	22	6	4	32
ATP-binding cassette sub-family C member 3	0	60	0	60
Multidrug resistance-associated protein 4	0	60	0	62
Solute carrier family 22 member 6	0	7	0	7
Carbonic anhydrase 12	0	17	2	33
UDP-glucuronosyltransferase 1A9	0	1	0	5
Bile salt export pump	0	15	0	15
Bile salt export pump	0	89	0	89
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	29	2	50
Carbonic anhydrase 2	0	32	8	59
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	0	1	2
Cytochrome P450 1A2	0	3	1	6
Prostaglandin G/H synthase 1	0	8	0	9
Carbonic anhydrase 3	0	17	2	27
Cytochrome P450 3A4	0	20	1	23
Cytochrome P450 2D6	0	18	1	21
Cytochrome P450 2C9	0	26	0	27
Polyunsaturated fatty acid lipoxygenase ALOX15	0	7	0	7
Gamma-aminobutyric acid receptor subunit beta-1	22	6	4	32
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	22	6	4	32
Gamma-aminobutyric acid receptor subunit gamma-2	22	6	5	33
UDP-glucuronosyltransferase 1-6	0	4	0	6
Gamma-aminobutyric acid receptor subunit alpha-5	22	6	4	32
Gamma-aminobutyric acid receptor subunit alpha-3	22	6	4	32
Arachidonate 5-lipoxygenase-activating protein	0	4	0	4
UDP-glucuronosyltransferase 1A1	0	4	0	5
Carbonic anhydrase 4	0	21	2	36
Prostaglandin G/H synthase 1	0	10	0	10
Carbonic anhydrase 6	0	18	2	33
Gamma-aminobutyric acid receptor subunit gamma-1	22	6	4	32
Gamma-aminobutyric acid receptor subunit alpha-2	22	6	4	32
Gamma-aminobutyric acid receptor subunit alpha-4	22	6	4	32
Gamma-aminobutyric acid receptor subunit gamma-3	22	6	4	32
Gamma-aminobutyric acid receptor subunit alpha-6	22	6	4	32
Carbonic anhydrase 5A, mitochondrial	0	18	4	37
Prostaglandin G/H synthase 2	0	9	1	11
Carbonic anhydrase 7	0	17	2	32
Nuclear receptor ROR-gamma	9	0	0	9
Cytochrome P450 2J2	0	17	0	17
Gamma-aminobutyric acid receptor subunit alpha-1	22	7	5	34
Gamma-aminobutyric acid receptor subunit beta-3	22	6	4	32
Gamma-aminobutyric acid receptor subunit beta-2	22	6	5	33
Carbonic anhydrase 9	0	21	2	37
GABA theta subunit	22	6	4	32
Canalicular multispecific organic anion transporter 1	0	56	0	56
Carbonic anhydrase 15	0	12	0	15
Carbonic anhydrase 13	0	13	0	24
Gamma-aminobutyric acid receptor subunit epsilon	22	6	4	32
Carbonic anhydrase 14	0	17	2	33
Carbonic anhydrase 5B, mitochondrial	0	17	2	34
toxin B	0	0	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	21	0	0	21
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	17	0	0	17
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	8
Carbonic anhydrase	0	9	0	9
thioredoxin reductase	34	0	0	34
GALC protein	7	0	0	7
cytochrome P450 family 3 subfamily A polypeptide 4	50	0	0	50
glucocorticoid receptor [Homo sapiens]	57	0	0	57
Carbonic anhydrase	0	9	0	9
Carbonic anhydrase	0	8	0	8
arylsulfatase A	26	0	0	26
Carbonic anhydrase	0	8	0	8
Bloom syndrome protein isoform 1	15	0	0	15
survival motor neuron protein isoform d	17	0	0	17
muscleblind-like protein 1 isoform 1	9	0	0	9
Carbonic anhydrase	0	8	0	8
Prolyl endopeptidase	0	5	0	5
Carbonic anhydrase-related protein 11	0	1	0	3
Glycogen phosphorylase, muscle form	0	3	0	3
Renin	0	2	0	2
Carbonic anhydrase 2	0	4	1	5
Cathepsin B	0	2	0	2
Steryl-sulfatase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	22	0	23
Polyunsaturated fatty acid 5-lipoxygenase	0	4	0	4
Cytochrome P450 2C8	0	5	0	5
Cytochrome P450 2A6	0	3	1	4
5-hydroxytryptamine receptor 2A	0	23	0	23
Androgen receptor	0	9	0	9
Translocator protein	0	2	0	2
Cannabinoid receptor 1	0	2	0	2
Cytochrome P450 2B6	0	5	1	8
Carbonic anhydrase 5A, mitochondrial	0	7	0	7
Adenosine receptor A1	0	6	1	9
Serum paraoxonase/arylesterase 1	0	4	0	4
Dipeptidyl peptidase 4	0	2	0	5
Endochitinase	0	1	0	1
Adenosine receptor A2a	0	7	3	12
5-hydroxytryptamine receptor 2B	0	18	0	18
Sodium-dependent serotonin transporter	0	13	3	17
Delta-type opioid receptor	0	14	0	14
Cytochrome P450 2C19	0	13	0	14
Delta-type opioid receptor	0	12	1	13
Mu-type opioid receptor	0	13	1	14
Carbonic anhydrase	0	8	0	10
Kappa-type opioid receptor	0	3	0	3
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	11	1	0	12
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	2	0	2
Carbonic anhydrase	0	8	0	11
D(2) dopamine receptor	0	18	0	19
Cholinesterase	0	8	0	9
Carbonic anhydrase	0	7	0	7
Mu-type opioid receptor	0	13	0	13
Fatty-acid amide hydrolase 1	0	5	0	5
Beta-carbonic anhydrase 1	0	8	0	8
Carbonic anhydrase 2	0	8	0	8
Glutamate receptor ionotropic, NMDA 2B	0	12	2	16
Squalene synthase	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	9	0	9
Carbonic anhydrase	0	8	0	11
Carbonic anhydrase 3	0	2	0	2
Carbonic anhydrase	0	6	0	10
Carbonic anhydrase	0	8	0	12
Carbonic anhydrase	0	9	0	9
Sigma intracellular receptor 2	0	6	0	6
Delta carbonic anhydrase	0	9	0	9
Sigma non-opioid intracellular receptor 1	0	8	1	9
Renin	0	1	0	1
Carbonic anhydrase	0	8	0	11
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	12	2	16
Carbonic anhydrase 4	0	13	0	15
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 7	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	32	0	0	32
Chain A, Membrane lipoprotein tmpC	0	0	2	2
Chain A, Membrane lipoprotein tmpC	0	0	2	2
Chain A, Membrane lipoprotein tmpC	0	0	2	2
Chain A, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain B, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Chain A, Uncharacterized protein MJ0883	0	0	1	1
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
regulator of G-protein signaling 4	21	0	0	21
NPYLR7B	0	0	3	3
IDH1	27	0	0	27
glycogen synthase kinase-3 beta isoform 1	0	0	4	4
mitogen-activated protein kinase 1	12	0	0	12
flap endonuclease 1	12	0	0	12
nuclear receptor ROR-gamma isoform 1	14	0	0	14
high affinity choline transporter 1 isoform a	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Calcium dependent protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
Sodium/nucleoside cotransporter 2	0	2	0	2
Rap guanine nucleotide exchange factor 3	8	0	0	8
Purine nucleoside phosphorylase	0	3	0	4
Epidermal growth factor receptor	0	10	0	10
Phosphoglycerate kinase 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Avidin	0	0	1	1
Adenosine deaminase	0	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	4	0	4
Insulin receptor	0	0	0	1
Phosphoglycerate kinase 2	0	1	0	1
Heat shock protein HSP 90-alpha	0	1	1	2
Platelet-derived growth factor receptor beta	0	0	0	1
Adenosine receptor A3	0	7	3	11
Heat shock 70 kDa protein 1A	0	1	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
Fibroblast growth factor receptor 1	0	2	0	3
Inosine-5'-monophosphate dehydrogenase 2	0	1	0	1
Endoplasmin	0	1	1	2
Inosine-5'-monophosphate dehydrogenase 1	0	1	0	1
Fibroblast growth factor receptor 2	0	1	0	2
Fibroblast growth factor receptor 4	0	1	0	3
Fibroblast growth factor receptor 3	0	1	0	2
Streptavidin	0	0	1	1
Adenosylhomocysteinase	0	1	0	3
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	4	4	9
Adenosine receptor A2b	0	0	1	2
Adenosine receptor A2b	0	2	3	5
Adenylate kinase 2, mitochondrial	0	1	0	1
Adenosine receptor A1	0	4	2	7
Adenylate kinase isoenzyme 1	0	1	0	1
Phosphatidylinositol 4-kinase alpha	0	2	0	3
Adenosine receptor A1	0	1	1	2
Adenosine kinase	0	0	0	1
Adenosine deaminase	0	1	0	2
Equilibrative nucleoside transporter 2	0	2	0	2
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	3
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	1	0	1
Equilibrative nucleoside transporter 1	0	2	0	2
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	3
Solute carrier family 28 member 3	0	2	0	2
Adenosine kinase	0	1	0	2
Phosphatidylinositol 4-kinase beta	0	2	0	3
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
Adenosine transporter 1	0	0	0	1
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	5	1	9
Glutamate receptor ionotropic, NMDA 1	0	12	2	16
Proton-coupled amino acid transporter 1	0	3	0	3
Adenosine deaminase	0	0	0	1
glp-1 receptor, partial	17	0	0	17
thyroid stimulating hormone receptor	22	0	0	22
Beta-2 adrenergic receptor	0	12	8	21
Beta-1 adrenergic receptor	0	14	7	21
60 kDa chaperonin	0	2	0	2
60 kDa heat shock protein, mitochondrial	0	2	0	2
Beta-3 adrenergic receptor	0	9	5	14
10 kDa heat shock protein, mitochondrial	0	2	0	2
Thiosulfate sulfurtransferase	0	2	0	2
Beta-2 adrenergic receptor	0	1	4	9
60 kDa chaperonin	0	2	0	2
10 kDa chaperonin	0	2	0	2
Beta-2 adrenergic receptor	0	2	7	10
ATP-dependent phosphofructokinase	29	0	0	29
TDP1 protein	56	0	0	56
pregnane X nuclear receptor	45	0	0	45
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	9	0	0	9
Bromodomain-containing protein 4	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	4	3	7
Gamma-aminobutyric acid receptor subunit gamma-2	0	4	2	6
Cholecystokinin receptor type A	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	3	3	6
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	3	6
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	3	6
Gamma-aminobutyric acid receptor subunit beta-2	0	3	2	5
Cholecystokinin receptor type A	0	1	0	1
ATPase family AAA domain-containing protein 5	15	0	0	15
Ataxin-2	30	0	0	30
Chain A, HADH2 protein	13	0	0	13
Chain B, HADH2 protein	13	0	0	13
USP1 protein, partial	26	0	0	26
NFKB1 protein, partial	9	0	0	9
cytochrome P450 2D6	36	0	0	36
cytochrome P450 2D6 isoform 1	21	0	0	21
D(1A) dopamine receptor	22	0	0	22
atrial natriuretic peptide receptor 2 precursor	7	0	0	7
serine/threonine-protein kinase mTOR isoform 1	15	0	0	15
muscarinic acetylcholine receptor M1	24	0	0	24
Solute carrier family 22 member 1	0	17	0	21
Polyunsaturated fatty acid lipoxygenase ALOX15B	9	0	0	9
Voltage-dependent L-type calcium channel subunit alpha-1F	0	6	1	7
5-hydroxytryptamine receptor 4	0	34	0	34
Albumin	0	0	6	6
High affinity nerve growth factor receptor	0	1	2	3
Aldo-keto reductase family 1 member B1	0	30	0	30
Muscarinic acetylcholine receptor M2	0	33	4	41
Muscarinic acetylcholine receptor M4	0	30	1	33
Muscarinic acetylcholine receptor M1	0	8	1	12
Muscarinic acetylcholine receptor M3	0	7	1	11
Muscarinic acetylcholine receptor M4	0	6	1	10
Muscarinic acetylcholine receptor M5	0	8	1	12
Muscarinic acetylcholine receptor M5	0	31	1	34
Alpha-2A adrenergic receptor	0	33	5	39
Muscarinic acetylcholine receptor M2	0	9	1	14
Muscarinic acetylcholine receptor M1	0	32	5	41
Angiotensin-converting enzyme	0	17	0	17
D(2) dopamine receptor	0	29	2	32
Alpha-2B adrenergic receptor	0	34	4	39
Alpha-2C adrenergic receptor	0	35	6	42
5-hydroxytryptamine receptor 1A	0	33	5	39
Muscarinic acetylcholine receptor M3	0	32	3	37
D(1A) dopamine receptor	0	21	1	23
D(1B) dopamine receptor	0	4	0	5
UDP-glucuronosyltransferase 1A4	0	3	0	8
Sodium-dependent noradrenaline transporter	0	42	4	46
Histamine H2 receptor	0	17	2	19
Alpha-1D adrenergic receptor	0	33	6	40
5-hydroxytryptamine receptor 2A	0	35	1	36
5-hydroxytryptamine receptor 2C	0	39	1	40
5-hydroxytryptamine receptor 1B	0	28	1	29
5-hydroxytryptamine receptor 1D	0	8	2	10
5-hydroxytryptamine receptor 1F	0	7	1	8
5-hydroxytryptamine receptor 6	0	5	0	5
Histamine H1 receptor	0	6	1	7
Sodium-dependent serotonin transporter	0	47	5	52
5-hydroxytryptamine receptor 7	0	8	0	8
5-hydroxytryptamine receptor 5A	0	5	0	5
5-hydroxytryptamine receptor 5B	0	5	0	5
Histamine H1 receptor	0	30	3	33
D(3) dopamine receptor	0	31	1	33
Sodium channel protein type 1 subunit alpha	0	3	0	3
Sodium channel protein type 4 subunit alpha	0	6	0	7
UDP-glucuronosyltransferase 1A3	0	0	0	4
5-hydroxytryptamine receptor 3A	0	7	0	7
5-hydroxytryptamine receptor 2B	0	37	1	38
Alpha-1A adrenergic receptor	0	28	3	31
Histamine H2 receptor	19	4	2	28
5-hydroxytryptamine receptor 6	0	24	1	26
5-hydroxytryptamine receptor 7	0	10	0	10
Voltage-dependent N-type calcium channel subunit alpha-1B	0	5	0	5
Sodium channel protein type 7 subunit alpha	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1D	0	6	1	7
Sodium-dependent dopamine transporter	0	32	3	35
Potassium voltage-gated channel subfamily H member 2	0	39	0	39
Voltage-dependent L-type calcium channel subunit alpha-1S	0	6	1	7
Voltage-dependent L-type calcium channel subunit alpha-1C	0	7	1	8
Sodium channel protein type 5 subunit alpha	0	7	0	7
Sodium channel protein type 9 subunit alpha	0	6	0	6
5-hydroxytryptamine receptor 4	0	5	0	5
Nuclear receptor subfamily 3 group C member 3	0	17	0	17
Sodium channel protein type 2 subunit alpha	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	39	1	40
5-hydroxytryptamine receptor 3B	0	7	0	7
Sodium channel protein type 3 subunit alpha	0	4	0	4
Sodium channel protein type 11 subunit alpha	0	3	0	3
Sodium channel protein type 8 subunit alpha	0	3	0	3
Histamine H3 receptor	0	6	2	8
Sodium channel protein type 10 subunit alpha	0	3	0	3
Chain A, Cruzipain	6	0	0	6
interleukin 8	6	0	0	6
farnesoid X nuclear receptor	30	0	0	30
vitamin D (1,25- dihydroxyvitamin D3) receptor	31	0	0	31
tumor necrosis factor	1	0	0	1
Aurora kinase B	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	4	0	5
Alpha-2B adrenergic receptor	0	20	4	24
Alpha-1A adrenergic receptor	0	13	10	24
Alpha-1B adrenergic receptor	0	8	8	17
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
alpha-galactosidase	3	0	0	3
cytochrome P450 2C19 precursor	8	0	0	8
DNA polymerase iota isoform a (long)	16	0	0	16
lethal factor (plasmid)	13	0	0	13
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	1	0	2
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
5-hydroxytryptamine receptor 3E	0	4	0	4
acetylcholinesterase	20	0	0	20
SMAD family member 2	16	0	0	16
Fumarate hydratase	15	0	0	15
PPM1D protein	11	0	0	11
SMAD family member 3	16	0	0	16
estrogen receptor 2 (ER beta)	29	0	0	29
G	23	0	0	23
polyprotein	15	0	0	15
67.9K protein	18	0	0	18
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	7	0	0	7
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	23	0	0	23
lysosomal alpha-glucosidase preproprotein	6	0	0	6
mu-type opioid receptor isoform MOR-1	0	0	3	3
nuclear factor erythroid 2-related factor 2 isoform 2	17	0	0	17
potassium voltage-gated channel subfamily H member 2 isoform d	21	0	0	21
transcriptional regulator ERG isoform 3	7	0	0	7
histone acetyltransferase KAT2A isoform 1	12	0	0	12
5-hydroxytryptamine receptor 2A	0	0	3	3
neuropeptide S receptor isoform A	6	0	0	6
Solute carrier family 22 member 2	0	2	0	5
5-hydroxytryptamine receptor 3A	0	1	1	2
5-hydroxytryptamine receptor 3B	0	4	0	4
Interferon beta	37	0	0	37
HLA class I histocompatibility antigen, B alpha chain	23	0	0	23
Cellular tumor antigen p53	46	0	0	46
ATP-dependent translocase ABCB1	0	17	2	26
5-hydroxytryptamine receptor 1A	0	15	7	22
Neuronal acetylcholine receptor subunit alpha-4	3	1	0	4
Neuronal acetylcholine receptor subunit beta-2	3	1	0	4
Alpha-1B adrenergic receptor	0	24	2	26
D	0	12	0	12
D(4) dopamine receptor	0	11	0	12
Alpha-1D adrenergic receptor	0	22	2	24
D(4) dopamine receptor	0	8	0	8
Histamine H1 receptor	0	5	3	8
5-hydroxytryptamine receptor 7	0	10	1	11
5-hydroxytryptamine receptor 3A	0	5	0	5
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
Spike glycoprotein	37	3	6	46
Inositol monophosphatase 1	9	0	0	9
5-hydroxytryptamine receptor 3D	0	4	0	4
Multidrug and toxin extrusion protein 2	0	2	0	2
5-hydroxytryptamine receptor 3C	0	4	0	4
Inositol hexakisphosphate kinase 1	23	0	0	23
Multidrug and toxin extrusion protein 1	0	10	0	10
cytochrome P450 2C9, partial	23	0	0	23
Chain A, Hyaluronidase, phage associated	0	1	0	1
thioredoxin glutathione reductase	6	0	0	6
lethal(3)malignant brain tumor-like protein 1 isoform I	3	0	0	3
Polyphenol oxidase 2	0	2	0	3
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	3	0	3
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, 2-oxoglutarate Oxygenase	14	0	0	14
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
hypothetical protein, conserved	2	0	0	2
glucocerebrosidase	7	0	0	7
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
DNA polymerase kappa isoform 1	12	0	0	12
Prostaglandin-H2 D-isomerase	0	2	0	2
Prostaglandin G/H synthase 1	0	5	0	6
Prostaglandin G/H synthase 2	0	4	0	5
Fatty acid-binding protein, liver	0	5	0	5
Integrin beta-3	4	2	1	7
Myeloperoxidase	0	3	0	3
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	4	1	1	6
Glutathione hydrolase 1 proenzyme	0	1	0	1
Substance-P receptor	0	4	0	4
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	2	0	2
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	6	0	6
Rho-associated protein kinase 2	0	2	0	2
Nicotinate phosphoribosyltransferase	0	3	0	3
Solute carrier family 22 member 20	0	4	0	4
Solute carrier family 22 member 6	0	4	0	4
Sigma non-opioid intracellular receptor 1	0	6	1	7
Atrial natriuretic peptide receptor 1	0	0	1	1
Atrial natriuretic peptide receptor 1	0	0	1	1
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	3	0	0	3
short transient receptor potential channel 6 isoform 1	0	0	1	1
Muscarinic acetylcholine receptor M1	0	0	1	2
Muscarinic acetylcholine receptor M4	0	1	0	1
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	1	2	3
Chain A, Ferritin light chain	14	0	0	14
P53	1	0	0	1
peripheral myelin protein 22 isoform 1	7	0	0	7
hemoglobin subunit beta	2	0	0	2
cellular tumor antigen p53 isoform a	8	0	0	8
M-phase phosphoprotein 8	10	0	0	10
Protein-arginine deiminase type-4	0	2	0	2
pregnane X receptor	10	0	0	10
nuclear receptor subfamily 1, group I, member 2	10	0	0	10
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	0	12	2	19
Glycine receptor subunit alpha-1	0	12	0	12
Glycine receptor subunit beta	0	12	0	12
Glycine receptor subunit alpha-2	0	12	0	12
Glycine receptor subunit alpha-3	0	12	0	12
ORF73	0	0	1	1
Beta-1 adrenergic receptor	0	1	5	8
hexokinase-4 isoform 1	3	0	0	3
glucokinase regulatory protein	3	0	0	3
Beta-1 adrenergic receptor	0	6	3	11
Chain A, CARBONIC ANHYDRASE IV	0	1	0	1
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7	0	0	0	3
importin subunit beta-1 isoform 1	6	0	0	6
snurportin-1	6	0	0	6
GTP-binding nuclear protein Ran isoform 1	4	0	0	4
Potassium channel subfamily K member 3	0	3	0	3
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	2	1	3
Potassium channel subfamily K member 9	0	1	0	1
Acetylcholine receptor subunit alpha	0	1	0	1
Acetylcholine receptor subunit gamma	0	1	0	1
Integrin alpha-5	0	1	0	1
Acetylcholine receptor subunit beta	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	4	0	9
Neuronal acetylcholine receptor subunit beta-2	0	1	0	2
Sodium-dependent dopamine transporter	0	16	1	17
Neuronal acetylcholine receptor subunit beta-4	0	1	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
UDP-glucuronosyltransferase 2B10	0	3	0	3
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	2
Acetylcholine receptor subunit delta	0	1	0	1
Vpr	4	0	0	4
Major prion protein	0	0	5	5
Sodium channel protein type 1 subunit alpha	0	3	0	3
Sodium channel protein type 2 subunit alpha	0	4	0	4
Sodium channel protein type 3 subunit alpha	0	3	0	3
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	2	0	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	5	0	0	5
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 16	0	0	0	1
Solute carrier family 22 member 21	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
Spike glycoprotein	0	3	6	9
Replicase polyprotein 1ab	0	3	7	10
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
Transmembrane protease serine 2	0	3	6	9
Dihydrofolate reductase	0	3	0	3
DNA ligase	0	1	0	1
Riboflavin-binding protein	0	0	1	1
Amyloid-beta precursor protein	1	4	0	5
Histidine-rich protein PFHRP-II	0	1	0	2
Procathepsin L	0	4	6	10
Replicase polyprotein 1a	0	3	6	9
Replicase polyprotein 1ab	0	3	6	9
Replicase polyprotein 1ab	0	3	6	9
Spike glycoprotein	0	1	0	1
Replicase polyprotein 1ab	0	3	6	9
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	1	0	1
DNA ligase 1	0	1	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Beta-secretase 1	0	3	1	4
Calcium-dependent protein kinase 1	0	0	1	1
MO15-related protein kinase Pfmrk	0	1	0	1
DNA ligase A	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Phosphoethanolamine N-methyltransferase	0	1	0	1
Angiotensin-converting enzyme 2	0	3	6	9
Cysteine proteinase falcipain 2a	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
Proteasome subunit beta type-11	0	0	0	1
Thrombopoietin	8	0	0	8
caspase 7, apoptosis-related cysteine protease	10	0	0	10
NADPH oxidase 1	0	1	0	1
Snq2p	0	0	0	3
caspase-3	10	0	0	10
Adenylate cyclase type 1	0	2	0	2
Caspase-7	6	0	0	6
caspase-3	6	0	0	6
histone deacetylase 9 isoform 3	3	0	0	3
ras-related protein Rab-9A	11	0	0	11
Proteasome subunit alpha type-7	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	5	0	5
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	5	0	5
Albumin	0	5	6	11
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Major prion protein	0	0	1	1
Tyrosine-protein kinase Fyn	0	5	0	5
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	3	1	4
Sphingomyelin phosphodiesterase	0	2	0	2
D(3) dopamine receptor	0	9	0	9
D(2) dopamine receptor	0	1	0	1
Proteasome subunit beta type-1	0	0	0	1
Substance-K receptor	0	8	0	8
Adenylate cyclase type 3	0	2	0	2
Alpha-2C adrenergic receptor	0	18	4	22
Alpha-2A adrenergic receptor	0	18	4	22
D(1B) dopamine receptor	0	6	0	6
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	2	1	3
Adenylate cyclase type 4	0	2	0	2
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	0	0	1
Trypanothione reductase	0	6	0	6
Melanocortin receptor 4	0	4	0	4
Melanocortin receptor 5	0	8	0	8
Pleiotropic ABC efflux transporter of multiple drugs	0	3	0	6
Mu-type opioid receptor	0	10	4	14
Adenylate cyclase type 8	0	2	0	2
Proteasome subunit beta type-10	0	0	0	1
Delta-type opioid receptor	0	12	1	13
Kappa-type opioid receptor	0	10	1	11
Melanocortin receptor 3	0	4	0	4
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Proteasome subunit alpha type-6	0	0	2	3
Calmodulin	0	1	2	3
Aldehyde oxidase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	10	2	14
Glutamate receptor ionotropic, NMDA 2C	0	10	2	14
Adenylate cyclase type 6	0	2	0	2
Adenylate cyclase type 5	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	7	0	7
Aldehyde oxidase	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	7	0	7
Glutamate receptor ionotropic, NMDA 2B	0	7	0	8
Glutamate receptor ionotropic, NMDA 2C	0	5	0	5
Glutamate receptor ionotropic, NMDA 2D	0	10	2	14
Adenylyl cyclase 7	0	2	0	2
Proteasome subunit alpha-type 8	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	5	0	5
Glutamate receptor ionotropic, NMDA 3B	0	10	2	14
D	0	1	0	1
Proteasome subunit beta type-7	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	10	2	14
NPC intracellular cholesterol transporter 1 precursor	7	0	0	7
Sodium-dependent noradrenaline transporter	0	3	0	3
Tryptophan 5-hydroxylase 1	0	4	0	4
Aldo-keto reductase family 1 member B1	0	4	0	4
Acetylcholinesterase	0	13	3	17
Aromatase	0	1	0	1
Sodium-dependent serotonin transporter	0	3	0	3
Sodium-dependent dopamine transporter	0	5	0	5
Transporter	0	15	0	15
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Beta-lactamase	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	2	0	2
3-dehydroquinate dehydratase	0	0	1	1
ATP-citrate synthase	0	1	0	2
Ribonuclease T	0	0	0	1
Cell death-related nuclease 4	0	0	0	1
3-dehydroquinate dehydratase	0	0	1	1
Prolyl 4-hydroxylase	0	2	0	2
Alpha-ketoglutarate-dependent dioxygenase FTO	0	2	0	2
urokinase-type plasminogen activator precursor	6	0	0	6
plasminogen precursor	6	0	0	6
urokinase plasminogen activator surface receptor precursor	6	0	0	6
streptokinase A precursor	0	0	3	3
Solute carrier organic anion transporter family member 1B3	0	9	0	10
Solute carrier organic anion transporter family member 1B1	0	9	0	9
atrial natriuretic peptide receptor 1 precursor	5	0	0	5
Trypanothione reductase	0	1	0	1
Envelope glycoprotein	0	0	4	4
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	12	0	0	12
Alpha-1B adrenergic receptor	0	0	2	2
cytochrome P450 2C9 precursor	12	0	0	12
Membrane primary amine oxidase	0	1	0	1
Solute carrier family 22 member 3	0	5	0	6
Alpha-1A adrenergic receptor	0	2	2	4
Amine oxidase [flavin-containing] A	0	3	0	3
Amine oxidase [flavin-containing] B	0	4	0	4
Alpha-2B adrenergic receptor	0	0	0	2
Alpha-2C adrenergic receptor	0	0	0	2
Alpha-2A adrenergic receptor	0	0	0	2
Alpha-2A adrenergic receptor	0	1	0	1
Nischarin	0	2	0	2
Solute carrier family 22 member 1	0	3	0	4
Nischarin	0	2	0	2
nonstructural protein 1	8	0	0	8
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	7	0	0	7
Liver carboxylesterase 1	0	2	0	5
Rap guanine nucleotide exchange factor 4	3	0	0	3
P2Y purinoceptor 12	0	3	0	3
Thromboxane A2 receptor	0	2	1	4
Prostaglandin E2 receptor EP1 subtype	0	3	2	5
Prostaglandin E2 receptor EP4 subtype	0	3	1	4
Prostaglandin F2-alpha receptor	0	2	2	4
Prostaglandin E2 receptor EP3 subtype	0	3	2	5
Prostaglandin E2 receptor EP2 subtype	0	3	1	4
Prostacyclin receptor	0	3	1	4
Prostaglandin D2 receptor	0	1	0	1
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	2	2	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	3	2	5
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	2	4
Gamma-aminobutyric acid receptor subunit epsilon	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	3	0	3
Leukotriene B4 receptor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	2	4
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
Leukotriene B4 receptor 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
Cytochrome P450 2D1	0	2	0	2
Cytochrome P450 2D26	0	2	0	2
Cytochrome P450 2D3	0	2	0	2
Kappa-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Cytochrome P450 2D4	0	2	0	2
Mas-related G-protein coupled receptor member X2	0	0	1	1
Luciferase	16	0	0	16
endonuclease IV	6	0	0	6
PAX8	0	0	0	1
nuclear receptor subfamily 0 group B member 1	0	2	0	2
steroidogenic factor 1	0	2	0	2
caspase-1 isoform alpha precursor	2	0	0	2
Tubulin alpha-1A chain	0	2	2	5
Tubulin beta chain	0	2	2	4
Plasma kallikrein	0	0	0	3
Tubulin beta-4A chain	0	3	3	8
ATP-dependent translocase ABCB1	0	2	0	2
Tubulin beta chain	0	3	3	8
Tubulin alpha-3C chain	0	3	3	8
Serine/threonine-protein kinase pim-1	0	1	0	1
ATP-dependent translocase ABCB1	0	3	0	3
Tubulin alpha-1B chain	0	3	3	8
Tubulin alpha-4A chain	0	3	3	8
Tubulin beta-4B chain	0	3	3	8
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	4	3	9
Tubulin beta-2A chain	0	3	3	8
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	3	3	8
Tubulin beta-2B chain	0	2	1	5
Tubulin alpha-3E chain	0	3	3	8
Tubulin alpha-1A chain	0	3	3	8
Similar to alpha-tubulin isoform 1	0	1	1	4
Similar to alpha-tubulin isoform 1	0	1	0	3
CREB-binding protein	1	0	0	1
Tubulin alpha-1C chain	0	3	3	8
Tubulin beta-6 chain	0	3	3	8
Tubulin beta-2B chain	0	3	3	8
Tubulin beta-1 chain	0	3	3	8
relaxin receptor 1 isoform 1	2	0	0	2
relaxin receptor 2 isoform 1	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	3	3
Solute carrier family 2, facilitated glucose transporter member 1	0	0	1	1
Adenylate cyclase type 8	0	0	1	1
Adenylate cyclase type 1	0	1	1	2
Relaxin receptor 1	0	0	1	1
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
dopamine D1 receptor	4	0	0	4
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	2	0	2
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
TAR DNA-binding protein 43	8	0	0	8
Deoxycytidine kinase	0	0	0	1
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-4	0	2	0	2
Taste receptor type 2 member 46	0	0	2	2
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Aldo-keto reductase family 1 member B10	0	2	0	2
Transient receptor potential cation channel subfamily A member 1	0	0	2	2
Dihydrofolate reductase	0	7	0	8
Cytochrome c oxidase subunit 2	0	2	0	2
Transthyretin	0	0	1	3
Interleukin-8	0	2	0	2
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
Fatty acid-binding protein, intestinal	0	2	0	2
Aldo-keto reductase family 1 member B1	0	3	0	3
Sodium- and chloride-dependent GABA transporter 1	0	4	0	4
C-X-C chemokine receptor type 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	4	0	4
Sodium- and chloride-dependent GABA transporter 3	0	4	0	4
Prostaglandin G/H synthase 2	0	4	0	5
Sodium- and chloride-dependent betaine transporter	0	4	0	4
Prostaglandin G/H synthase 2	0	3	0	4
Solute carrier family 22 member 6	0	3	0	6
Prostaglandin G/H synthase 1	0	4	0	5
P2Y purinoceptor 12	0	2	0	2
UDP-glucuronosyltransferase 1A7	0	1	0	1
UDP-glucuronosyltransferase 1A10	0	1	0	1
Cereblon isoform 4	0	4	0	4
Choline O-acetyltransferase	0	3	0	3
Protein cereblon	0	4	0	4
Insulin-like growth factor-binding protein 5	0	0	1	1
prostaglandin E2 receptor EP2 subtype	1	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Prostaglandin E2 receptor EP3 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	0	2
Prostaglandin E2 receptor EP1 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Solute carrier organic anion transporter family member 2A1	0	1	0	2
Solute carrier family 22 member 7	0	0	0	2
Prostaglandin E2 receptor EP2 subtype	0	2	0	2
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 8	0	3	0	5
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	2
Solute carrier family 22 member 11	0	0	0	2
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
huntingtin isoform 2	8	0	0	8
Tyrosine-protein kinase Lck	0	2	0	2
POU domain, class 2, transcription factor 1	0	0	0	2
Acetylcholinesterase	0	8	0	9
cGMP-specific 3',5'-cyclic phosphodiesterase	0	2	0	2
Acetylcholinesterase	0	2	1	3
Cholinesterase	0	9	0	9
Amine oxidase [flavin-containing] B	0	3	0	3
Amine oxidase [flavin-containing] A	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Acetylcholinesterase	0	2	0	2
Acetylcholinesterase	0	3	0	3
Acetylcholinesterase	0	2	0	2
Glycogen synthase kinase-3 beta	0	1	0	1
Cholinesterase	0	2	0	2
Acetylcholine receptor subunit epsilon	0	1	0	1
Cytochrome P450 1B1	0	1	0	1
Acyl-CoA:cholesterol acyltransferase	0	2	0	2
Carboxylic ester hydrolase	0	2	0	3
Carboxylic ester hydrolase	0	3	0	3
Chain A, CARBONIC ANHYDRASE II	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	1	0	1
Androgen receptor	0	3	1	4
Beta-2 adrenergic receptor	0	5	1	7
Beta-3 adrenergic receptor	0	3	2	5
Alpha-synuclein	2	0	0	2
Endothelin-1 receptor	0	3	1	4
Vascular endothelial growth factor receptor 2	0	1	0	1
Receptor-type tyrosine-protein kinase FLT3	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Genome polyprotein	0	2	1	3
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
thyrotropin-releasing hormone receptor	4	0	0	4
ubiquitin carboxyl-terminal hydrolase 2 isoform a	6	0	0	6
eyes absent homolog 2 isoform a	1	0	0	1
Flavin reductase (NADPH)	0	0	2	2
large T antigen	0	1	0	1
pyruvate kinase PKM isoform b	2	0	0	2
Ornithine decarboxylase	2	0	0	2
Kappa-type opioid receptor	0	2	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	9	0	0	9
Solute carrier organic anion transporter family member 1A4	0	1	0	2
DNA gyrase subunit B	0	2	0	2
DNA gyrase subunit A	0	2	0	2
Solute carrier organic anion transporter family member 1A1	0	1	0	2
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Histamine H4 receptor	0	2	2	4
Solute carrier family 15 member 1	0	1	0	1
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Skn7p	0	0	0	1
Solute carrier family 22 member 8	0	0	0	1
Thymidylate synthase	0	3	0	3
Aromatase	0	1	0	1
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Cytochrome P450 1A2	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	3	0	3
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	2	0	2
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Sodium/bile acid cotransporter	0	3	0	3
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Gamma-aminobutyric acid	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	2	2
Histone deacetylase 3	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 2	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit delta	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Histone deacetylase 4	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-3	0	0	1	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Histone deacetylase 1	0	3	0	3
Sterol O-acyltransferase 1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	0	1	1
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	3	0	3
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	3	0	3
Histone deacetylase 8	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Platelet glycoprotein VI	0	1	2	4
Gamma-aminobutyric acid receptor subunit theta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	0	1	1
Histone deacetylase 6	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 1	0	0	1	1
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	5	0	0	5
Metabotropic glutamate receptor 8	0	2	0	2
Metabotropic glutamate receptor 6	0	1	1	3
Excitatory amino acid transporter 4	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	2
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
Glutamate receptor 1	0	2	1	3
Glutamate receptor 3	0	2	1	3
Glutamate receptor 4	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	1	2	3
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Excitatory amino acid transporter 1	0	2	0	3
Excitatory amino acid transporter 2	0	2	0	3
Excitatory amino acid transporter 3	0	2	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Metabotropic glutamate receptor 1	0	1	1	3
Metabotropic glutamate receptor 2	0	1	1	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	3
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	2
Ricin	0	2	0	2
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Purine nucleoside phosphorylase	0	0	2	4
Shiga toxin subunit A	0	1	0	1
Guanine deaminase	0	2	0	3
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
apical membrane antigen 1, AMA1	2	0	0	2
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Macrophage migration inhibitory factor	0	2	0	2
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Equilibrative nucleoside transporter 4	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Histamine H3 receptor	0	1	0	1
Solute carrier family 22 member 2	0	2	0	3
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
Chain A, Purine-nucleoside Phosphorylase	0	1	0	1
Chain C, Xanthine dehydrogenase/oxidase	0	0	1	1
Acid-sensing ion channel 3	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	4
Prostaglandin G/H synthase 1	0	2	0	2
Caspase-1	0	2	0	3
Aldo-keto reductase family 1 member C3	0	5	0	5
Caspase-3	0	1	0	1
Caspase-4	0	1	0	1
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Acid-sensing ion channel 1	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
5-hydroxytryptamine receptor 2C	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
Parkin	3	0	0	3
Prostaglandin E synthase	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	4	0	4
Phospholipase A2, major isoenzyme	0	1	0	1
Aldo-keto reductase family 1 member C4	0	2	0	2
Thromboxane-A synthase	0	3	0	3
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	2
Bifunctional epoxide hydrolase 2	0	2	0	2
Peroxisome proliferator-activated receptor gamma	0	0	1	1
C-X-C chemokine receptor type 3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	3	0	3
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Lactoylglutathione lyase	0	1	0	1
Aldo-keto reductase family 1 member C1	0	3	0	3
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
Chain A, ADENOSINE DEAMINASE	0	1	0	1
Chain A, ADENOSINE DEAMINASE	0	1	0	1
Lysosomal protective protein	0	1	0	1
Fatty acid synthase	0	1	0	1
Liver carboxylesterase	0	1	0	1
Beta-2 adrenergic receptor	0	0	1	1
Beta-adrenergic receptor kinase 1	0	1	3	4
Beta-3 adrenergic receptor	0	0	1	1
Vasopressin V1a receptor	0	0	1	1
Beta-1 adrenergic receptor	0	2	1	3
Beta-2 adrenergic receptor	0	2	0	2
Taste receptor type 2 member 38	0	0	1	1
Taste receptor type 2 member 39	0	0	1	1
Taste receptor type 2 member 40	0	0	1	1
Taste receptor type 2 member 41	0	0	1	1
Taste receptor type 2 member 43	0	0	1	1
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 45	0	0	1	1
Taste receptor type 2 member 30	0	0	1	1
Taste receptor type 2 member 19	0	0	1	1
Taste receptor type 2 member 20	0	0	1	1
Taste receptor type 2 member 50	0	0	1	1
Taste receptor type 2 member 60	0	0	1	1
Oxytocin receptor	0	0	1	1
Taste receptor type 2 member 42	0	0	1	1
Taste receptor type 2 member 16	0	0	1	1
Taste receptor type 2 member 14	0	0	1	2
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 10	0	0	1	1
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 8	0	0	1	1
Taste receptor type 2 member 7	0	0	1	1
Taste receptor type 2 member 5	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Taste receptor type 2 member 3	0	0	1	1
Taste receptor type 2 member 1	0	0	1	1
serine/threonine-protein kinase PLK1	2	0	0	2
DNA polymerase eta isoform 1	3	0	0	3
Ornithine decarboxylase	0	0	0	1
Retinoic acid receptor alpha	0	1	0	1
Retinoic acid receptor gamma	0	1	0	1
Retinoic acid receptor beta	0	1	0	1
Cellular retinoic acid-binding protein 2	0	0	1	1
Mitogen-activated protein kinase 1	0	2	0	2
Retinoic acid receptor RXR-alpha	0	1	0	1
Retinoic acid receptor RXR-beta	0	1	0	1
Retinoic acid receptor RXR-gamma	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	1
Cellular retinoic acid-binding protein 1	0	0	1	1
Mitogen-activated protein kinase 14	0	2	0	2
Olfactory receptor 51E2	0	1	1	2
Chymotrypsinogen A	0	2	0	2
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Translocator protein	0	1	0	1
Neprilysin	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
Atrial natriuretic peptide receptor 3	0	1	0	1
Type-1A angiotensin II receptor	0	3	1	4
Type-1B angiotensin II receptor	0	4	0	4
Type-1 angiotensin II receptor	0	3	2	7
Type-1 angiotensin II receptor	0	1	1	2
Type-2 angiotensin II receptor	0	6	0	6
Type-2 angiotensin II receptor	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	2	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	2	0	2
Type-1 angiotensin II receptor	0	2	1	3
5-hydroxytryptamine receptor 1A	0	2	0	2
histone-lysine N-methyltransferase NSD2 isoform 1	0	0	0	1
MBT domain-containing protein 1	0	2	0	2
Lethal(3)malignant brain tumor-like protein 4	0	2	0	2
Lethal(3)malignant brain tumor-like protein 3	0	2	0	2
Lethal(3)malignant brain tumor-like protein 1	0	2	0	2
Transient receptor potential cation channel subfamily M member 2	0	1	0	1
Beta-lactamase	0	1	0	1
Myc proto-oncogene protein	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Peroxisome proliferator-activated receptor alpha	1	0	0	1
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Synaptic vesicular amine transporter	0	1	0	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	3	3
Trace amine-associated receptor 1	0	0	2	2
corticotropin-releasing hormone receptor 2	0	1	1	2
corticotropin releasing factor-binding protein	0	1	1	2
Tyrosine-protein kinase ABL1	0	2	1	3
Dihydrofolate reductase	0	5	3	9
Cyclin-dependent kinase 2	0	1	1	2
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
acid sphingomyelinase	1	0	0	1
ClpP	1	0	0	1
15-lipoxygenase, partial	2	0	0	2
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	3	0	3
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	4	0	4
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Bifunctional purine biosynthesis protein ATIC	0	3	0	3
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Caspase-7	1	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Endothelin receptor type B	0	1	0	1
5-hydroxytryptamine receptor 3A	0	2	0	2
Endothelin receptor type B	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
5-hydroxytryptamine receptor 3B	0	2	0	2
G-protein coupled receptor	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Sodium/iodide cotransporter	0	1	0	1
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	4	0	0	4
Transporter	0	1	0	1
Neuraminidase	0	2	0	2
Neuraminidase	0	4	0	4
Neuraminidase	0	2	0	2
Neuraminidase	0	2	0	2
Neuraminidase	0	2	0	2
Neuraminidase	0	2	0	2
Sialidase	0	2	0	2
Acyl-CoA desaturase 1	0	1	0	1
Neuraminidase	0	2	0	2
Neuraminidase	0	2	0	2
Neuraminidase	0	1	0	1
Neuraminidase	0	1	0	1
Sialidase-4	0	1	0	1
Sialidase-1	0	1	0	1
Sialidase-3	0	1	0	1
Sialidase-2	0	1	0	1
Genome polyprotein	0	1	0	1
Integrin alpha-V	0	1	0	1
Botulinum neurotoxin type A	0	1	0	1
Apoptosis regulator Bcl-2	0	1	0	1
Cholecystokinin receptor type A	0	3	1	4
Bcl-2-like protein 1	0	1	0	1
Tyrosine-protein kinase Mer	0	1	0	1
Beta-tubulin	0	1	0	1
Nucleotide-binding oligomerization domain-containing protein 2	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
Cannabinoid receptor 2	0	1	0	1
Corticotropin-releasing factor receptor 2	0	1	0	1
Transient receptor potential cation channel subfamily V member 1	0	0	1	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Quinolone resistance protein NorA	0	1	0	1
Beta-adrenergic receptor kinase 1	0	1	0	1
Potassium voltage-gated channel subfamily A member 3	0	1	0	1
Substance-P receptor	0	3	0	3
Rhodopsin kinase GRK1	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
P2X purinoceptor 4	0	1	0	1
Rhodopsin kinase GRK1	0	1	0	1
Beta-adrenergic receptor kinase 1	0	0	0	1
Alpha-1B adrenergic receptor	0	3	0	3
Phenylethanolamine N-methyltransferase	0	0	0	1
Acetylcholinesterase	0	1	0	1
Muscarinic acetylcholine receptor DM1	0	1	0	1
Cytochrome P450 2A13	0	1	1	2
luciferase	0	0	0	1
Estrogen receptor	0	4	1	6
Progesterone receptor	0	3	0	4
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	4	1	5
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	1	0	1
Glutamate 5-kinase	0	0	0	1
Neutral amino acid transporter A	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
Chloroquine resistance transporter	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
heat shock protein 90, putative	0	0	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
5-hydroxytryptamine receptor 1B	0	6	3	9
Neuromedin-K receptor	0	0	1	1
Vasopressin V1a receptor	0	1	1	2
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
RGS12	1	0	0	1
pyruvate kinase	1	0	0	1
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	1	0	0	1
dual specificity protein phosphatase 3	0	1	0	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
tyrosine-protein phosphatase non-receptor type 22 isoform 1	0	1	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
Estrogen receptor	0	0	2	3
Beta-hexosaminidase subunit alpha	0	1	0	2
Beta-hexosaminidase subunit beta	0	1	0	1
Substance-K receptor	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Trace amine-associated receptor 5	0	0	1	1
Estrogen receptor beta	0	0	2	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Multidrug and toxin extrusion protein 1	0	1	0	1
Lysine-specific histone demethylase 1A	0	1	0	1
L-lactate dehydrogenase A chain	0	1	0	1
Beta-lactamase	0	1	0	1
Cystic fibrosis transmembrane conductance regulator	0	0	1	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Mitogen-activated protein kinase 10	0	1	0	1
Dihydroorotate dehydrogenase	0	1	0	1
Substance-K receptor	0	1	0	1
Neuromedin-U receptor 2	0	0	1	1
Transcriptional activator protein LuxR	0	3	0	3
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Protein argonaute-2	0	0	1	1
Chain A, Glutathione S-transferase	0	1	0	1
Tumor necrosis factor	0	0	1	1
Interstitial collagenase	0	1	0	1
Fibroblast growth factor 1	0	0	1	1
Cystine/glutamate transporter	0	1	0	1
Carboxypeptidase M	0	1	0	1
5-hydroxytryptamine receptor 1E	0	1	0	1
5-hydroxytryptamine receptor 1F	0	2	1	3
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 1B	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1B	0	1	0	1
Chain A, CES1 protein	0	1	0	1
DNA polymerase III, partial	1	0	0	1
interferon gamma precursor	0	0	0	1
ubiquitin-conjugating enzyme E2 N	0	2	0	2
Serine/threonine-protein kinase D3	0	1	0	1
Lysosomal acid glucosylceramidase	0	0	1	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Steroid hormone receptor ERR1	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Protein kinase C eta type	0	1	0	1
B2 bradykinin receptor	0	2	0	2
C-8 sterol isomerase	0	1	0	1
Protein kinase C iota type	0	1	0	1
Estrogen-related receptor gamma	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Phospholipase D1	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C theta type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Protein kinase C delta type	0	1	0	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Platelet-activating factor acetylhydrolase	0	1	0	1
Phospholipase D1	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	2	1	3
Serine/threonine-protein kinase D1	0	1	0	1
Protein kinase C eta type	0	1	0	1
Emopamil-binding protein-like	0	1	0	1
7-dehydrocholesterol reductase	0	1	1	2
Protein kinase C theta type	0	1	0	1
Alpha-1A adrenergic receptor	0	1	1	2
Alpha-1D adrenergic receptor	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
XBP1	0	1	0	1
DNA damage-inducible transcript 3 protein	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
C-C chemokine receptor type 5	0	2	0	2
Thymidine phosphorylase	0	1	0	1
P2Y purinoceptor 13	0	1	0	1
Chain A, Carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Large neutral amino acids transporter small subunit 1	0	2	0	2
SLC16A10 protein	0	0	0	1
Monocarboxylate transporter 10	0	0	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Chain A, Arginase 1	0	1	0	1
Cocaine esterase	0	1	0	1
Tissue factor	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
Xanthine dehydrogenase/oxidase	0	0	0	1
Amine oxidase [flavin-containing]	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(5)

Research Excerpts

Overview

Context

Treatment

Research

Studies (1,373)

Protein Targets (1,468)

Glaucoma, Angle Closure

Synonyms(5)

Research Excerpts

Overview

Context

Treatment

Research

Studies (1,373)

Drugs Studied (248)

Protein Targets (1,468)