| Member | Definition | Class |
|---|
| ageladine a | An imidazopyridine that is 1H-imidazo[4,5-c]pyridin-2-amine substituted by a 4,5-dibromo-1H-pyrrol-2-yl group at position 4. It is an alkaloid isolated from a marine sponge Agelas nakamurai and acts as an inhibitor of the matrix metalloproteinases, the key enzymes involved in tumour growth, migration, angiogenesis, invasion and metastasis. | ageladine A |
| aurapten | A member of the class of coumarins that is umbelliferone in which the phenolic hydrogen has been replaced by a geranyl group. Ii is isolated from several edible fruits and vegetables and exhibits a variety of therapeutic properties. | auraptene |
| batimastat | A secondary carboxamide resulting from the formal condensation of the carboxy group of (2S,3R)-5-methyl-3-{[(2S)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-2-[(thiophen-2-ylsulfanyl)methyl]hexanoic acid with the amino group of hydroxylamine. It a broad-spectrum matrix metalloprotease inhibitor. | batimastat |
| marimastat | A secondary carboxamide resulting from the foraml condensation of the carboxy group of (2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoic acid with the alpha-amino group of N,3-dimethyl-L-valinamide. | marimastat |
| prinomastat | A hydroxamic acid that is (3S)-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide in which the hydrogen attached to the thiomorpholine nitrogen has been replaced by a [4-(pyridin-4-yloxy)phenyl]sulfonyl group. It is a selective inhibitor with of matrix metalloproteinases (MMPs) 2, 3, 9, 13, and 14. | prinomastat |
| ramipril | A dipeptide that is the prodrug for ramiprilat, the active metabolite obtained by hydrolysis of the ethyl ester group. An angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure. | ramipril |
| ramiprilat | A dipeptide that is the active metabolite of ramipril. An angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure. | ramiprilat |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 5-hydroxytryptamine receptor 3A | Homo sapiens (human) | IC50 | 0.0250 | 1 | 1 |
| 5-hydroxytryptamine receptor 3B | Homo sapiens (human) | IC50 | 0.0250 | 1 | 1 |
| 5-hydroxytryptamine receptor 3C | Homo sapiens (human) | IC50 | 0.0250 | 1 | 1 |
| 5-hydroxytryptamine receptor 3D | Homo sapiens (human) | IC50 | 0.0250 | 1 | 1 |
| 5-hydroxytryptamine receptor 3E | Homo sapiens (human) | IC50 | 0.0250 | 1 | 1 |
| 72 kDa type IV collagenase | Homo sapiens (human) | IC50 | 0.4841 | 22 | 28 |
| 72 kDa type IV collagenase | Homo sapiens (human) | Ki | 0.0002 | 5 | 5 |
| A disintegrin and metalloproteinase with thrombospondin motifs 4 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| A disintegrin and metalloproteinase with thrombospondin motifs 5 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Acyl carrier protein, mitochondrial | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| ADAM10 | Homo sapiens (human) | IC50 | 0.0482 | 2 | 2 |
| Amine oxidase [flavin-containing] A | Mus musculus (house mouse) | IC50 | 0.0000 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Mus musculus (house mouse) | IC50 | 0.3000 | 2 | 2 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | IC50 | 0.2530 | 2 | 2 |
| Angiotensin-converting enzyme | Homo sapiens (human) | IC50 | 0.0040 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Beta-secretase 1 | Homo sapiens (human) | IC50 | 345.1000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Casein kinase I isoform alpha | Sus scrofa (pig) | IC50 | 50.0000 | 1 | 1 |
| Chain A, A disintegrin and metalloproteinase with thrombospondin motifs 5 | Homo sapiens (human) | IC50 | 0.1060 | 1 | 2 |
| Chain A, Catalytic Domain of ADAMTS-5 | Homo sapiens (human) | IC50 | 0.1060 | 1 | 1 |
| Collagenase 3 | Homo sapiens (human) | IC50 | 0.0104 | 11 | 15 |
| Collagenase 3 | Homo sapiens (human) | Ki | 0.0000 | 2 | 2 |
| Complex I intermediate-associated protein 30, mitochondrial | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| Cytochrome c oxidase subunit NDUFA4 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0031 | 1 | 1 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | IC50 | 5.6068 | 4 | 6 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | Ki | 0.0024 | 3 | 3 |
| disintegrin and metalloproteinase domain-containing protein 17 isoform 1 preproprotein | Homo sapiens (human) | IC50 | 0.0184 | 2 | 2 |
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | Rattus norvegicus (Norway rat) | IC50 | 30.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| Interstitial collagenase | Homo sapiens (human) | IC50 | 0.4764 | 19 | 26 |
| Interstitial collagenase | Homo sapiens (human) | Ki | 0.0041 | 7 | 7 |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | IC50 | 0.0031 | 1 | 1 |
| Low affinity immunoglobulin epsilon Fc receptor | Homo sapiens (human) | IC50 | 0.1000 | 2 | 2 |
| Macrophage metalloelastase | Homo sapiens (human) | IC50 | 4.1970 | 5 | 5 |
| Matrilysin | Homo sapiens (human) | IC50 | 1.7264 | 8 | 10 |
| Matrilysin | Homo sapiens (human) | Ki | 0.0540 | 1 | 1 |
| Matrix metalloproteinase-14 | Homo sapiens (human) | IC50 | 1.4290 | 8 | 9 |
| Matrix metalloproteinase-15 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Matrix metalloproteinase-16 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Matrix metalloproteinase-20 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Matrix metalloproteinase-24 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Matrix metalloproteinase-25 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Matrix metalloproteinase-26 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Matrix metalloproteinase-9 | Homo sapiens (human) | IC50 | 0.5424 | 16 | 20 |
| Matrix metalloproteinase-9 | Homo sapiens (human) | Ki | 0.0077 | 3 | 3 |
| Melatonin receptor type 1A | Gallus gallus (chicken) | IC50 | 0.0049 | 1 | 1 |
| Melatonin receptor type 1A | Homo sapiens (human) | Ki | 1.9000 | 1 | 1 |
| Melatonin receptor type 1B | Gallus gallus (chicken) | IC50 | 0.0049 | 1 | 1 |
| Melatonin receptor type 1C | Gallus gallus (chicken) | IC50 | 0.0049 | 1 | 1 |
| Metabotropic glutamate receptor 5 | Rattus norvegicus (Norway rat) | IC50 | 1.2000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 subunit C2 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH-ubiquinone oxidoreductase chain 1 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH-ubiquinone oxidoreductase chain 2 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH-ubiquinone oxidoreductase chain 3 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH-ubiquinone oxidoreductase chain 4 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH-ubiquinone oxidoreductase chain 4L | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH-ubiquinone oxidoreductase chain 5 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH-ubiquinone oxidoreductase chain 6 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| Neutrophil collagenase | Homo sapiens (human) | IC50 | 1.3384 | 7 | 8 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Homo sapiens (human) | IC50 | 23.9000 | 1 | 1 |
| Serine/threonine-protein kinase pim-1 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Cavia porcellus (domestic guinea pig) | IC50 | 0.0031 | 1 | 1 |
| Snake venom metalloproteinase BaP1 | Bothrops asper (terciopelo) | IC50 | 1.2000 | 1 | 1 |
| Stromelysin-1 | Homo sapiens (human) | IC50 | 0.8071 | 15 | 20 |
| Stromelysin-1 | Homo sapiens (human) | Ki | 0.0300 | 6 | 6 |
| Stromelysin-2 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Tumor necrosis factor | Homo sapiens (human) | IC50 | 1.0010 | 1 | 1 |
| Zinc metalloproteinase dpy-31 | Brugia malayi | IC50 | 199.5260 | 1 | 1 |
| Zinc metalloproteinase dpy-31 | Teladorsagia circumcincta | IC50 | 79.4328 | 1 | 1 |