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fluoroquinolone antibiotic
An organonitrogen heterocyclic antibiotic containing a quinolone (or quinolone-like) moiety and which have a fluorine atom attached to the central ring system.
ChEBI ID: 87211
Members (16)
| Member | Definition | Role |
|---|---|---|
| bay-s 9435 | An organosulfonic acid that is ciprofloxacin carrying a sulfo group at position 4 of the piperazine ring. It is a metabolite of ciprofloxacin. | sulfociprofloxacin |
| ciprofloxacin | A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively. | ciprofloxacin zwitterion; ciprofloxacin |
| difloxacin | A quinolone that is pefloxacin in which the ethyl group at position 1 of the quinolone has been replaced by a p-fluorophenyl group. A broad-spectrum antibiotic effective against both Gram-positive and Gram-negative bacteria, it is used (usually as the monohydrochloride salt) for the treatment of bacterial infections in dogs. | difloxacin |
| enoxacin | A 1,8-naphthyridine derivative that is 1,4-dihydro-1,8-naphthyridine with an ethyl group at the 1 position, a carboxy group at the 3-position, an oxo sustituent at the 4-position, a fluoro substituent at the 5-position and a piperazin-1-yl group at the 7 position. An antibacterial, it is used in the treatment of urinary-tract infections and gonorrhoea. | enoxacin |
| fleroxacin | A fluoroquinolone antibiotic that is 4-oxo-1,4-dihydroquinoline which is substituted at positions 1, 3, 6, 7 and 8 by 2-fluoroethyl, carboxy, fluoro, 4-methylpiperazin-1-yl and fluoro groups, respectively. It is active against many Gram-positive and Gram-negative bacteria. | fleroxacin |
| gemifloxacin | A 1,4-dihydro-1,8-naphthyridine with a carboxy group at the 3-position, an oxo sustituent at the 4-position, a fluoro substituent at the 5-position and a substituted pyrrolin-1-yl group at the 7-position. | gemifloxacin |
| grepafloxacin | Grepafloxacin | |
| levofloxacin | An optically active form of ofloxacin having (S)-configuration; an inhibitor of bacterial topoisomerase IV and DNA gyrase. | levofloxacin |
| lomefloxacin | A fluoroquinolone antibiotic, used (generally as the hydrochloride salt) to treat bacterial infections including bronchitis and urinary tract infections. It is also used to prevent urinary tract infections prior to surgery. | lomefloxacin |
| moxifloxacin | A quinolone that consists of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid bearing a cyclopropyl substituent at position 1, a fluoro substitiuent at position 6, a (4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl group at position 7 and a methoxy substituent at position 8. A member of the fluoroquinolone class of antibacterial agents. | moxifloxacin |
| norfloxacin | A quinolinemonocarboxylic acid with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase. | norfloxacin |
| pefloxacin | A quinolone that is 4-oxo-1,4-dihydroquinoline which is substituted at positions 1, 3, 6 and 7 by ethyl, carboxy, fluorine, and 4-methylpiperazin-1-yl groups, respectively. | pefloxacin |
| prulifloxacin | Prulifloxacin | |
| rufloxacin | Rufloxacin | |
| sitafloxacin | Sitafloxacin | |
| sparfloxacin | sparfloxacin |
Research
Studies (25,164)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 2,191 (8.71) | 18.7374 |
| 1990's | 4,924 (19.57) | 18.2507 |
| 2000's | 6,750 (26.82) | 29.6817 |
| 2010's | 8,134 (32.32) | 24.3611 |
| 2020's | 3,165 (12.58) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 3,298 (10.65%) | 5.53% |
| Reviews | 1,475 (4.76%) | 6.00% |
| Case Studies | 3,302 (10.66%) | 4.05% |
| Observational | 115 (0.37%) | 0.25% |
| Other | 22,774 (73.55%) | 84.16% |